JP2014152172A - Refreshing feeling-imparting external composition, refreshing feeling-imparting patch, refreshing feeling-imparting method, production method of refreshing feeling-imparting external composition, and production method of refreshing feeling-imparting patch - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a refreshing feeling-imparting external composition or a refreshing feeling-imparting patch, which allows successful interaction of menthol contained in the refreshing feeling-imparting external composition with moisture content present on the human skin surface when applied or stuck to the human skin, so that cold sense-receptors of sensory nerves scattered in the human skin are stimulated to suppress discomfort sensation like pain-feeling by strong stimulation of the menthol, resulting in continuous brisk refreshing feeling and cold sensation with less pain sensation during the presence of the skin moisture content.SOLUTION: A refreshing feeling-imparting external composition or a refreshing feeling-imparting patch contains at least menthol and a medium component, where the menthol is contained in the medium component in the state of being dissolved, in the state of being precipitation-dispersed or in the state of being supported. By interaction of the menthol with a sweat component supplied from the human skin or a moisture content adhered to the skin, the action that the human body gets refreshing feeling or cold sensation is succeeded.

Description

Detailed Description of the Invention

  The present invention relates to a refreshing sensation-providing external composition, a refreshing sensation imparting patch, a refreshing sensation imparting method, and a refreshing sensation imparting external composition, which exerts an effect that the human body feels a refreshing sensation or cooling sensation when applied or applied to human skin. It relates to the manufacturing method.

In general, menthol is known as a cooling sensation component that has the effect of making the human body feel a refreshing feeling or a cooling sensation. When a cold sensation component such as menthol is brought into contact with the skin, the human skin gets a cool sensation. This is not because the temperature actually decreases, but because the cooling component stimulates the cold receptor of the sensory nerve that causes the cooling of the human skin.
Menthol is a colorless crystalline solid at room temperature having a melting point of about 41 ° C. to about 45 ° C. and a boiling point of about 212 ° C. to about 216 ° C., and has volatility, room temperature sublimation and skin irritation, and a cooling agent, cooling sensation It is used as an agent, a transdermal absorption enhancer, a local vasodilator, a bath agent, and the like. Menthol has lipophilicity, is hardly soluble in water, and is easily soluble in alcohols and oils.
The following various patent applications have been proposed as a refreshing sensation imparting external composition and a refreshing sensation imparting patch using such menthol.

  In Japanese Patent No. 3908275 (Patent Document 1), the plaster composition does not contain sodium chloride and other medicinal ingredients, and is 5 to 15% by weight of a water-soluble polymer substance, 10 to 50% by weight of a polyhydric alcohol, Contains water 25-70 wt%, 1-menthol 0.1-5 wt%, and ethanol 0.1-2 wt%, the weight ratio of ethanol to 1-menthol is 1: 1-1: 2. There is disclosed a long-lasting cooling sensation patch characterized by the above, and thereby exhibiting excellent characteristics in sustaining the cooling effect time.

  JP-A-2003-55193 (Patent Document 2) includes (a) 0.01 to 0.3% by mass of a cooling agent such as menthol, (b) 0.1 to 10% by mass of a gelling agent, (c 1) Gel external preparation characterized by containing 1 to 10% by weight of alcohol such as ethanol, and (d) 50 to 98% by weight of water, and is particularly used as an acupuncture agent, and the release of the drug is fast. A gel-like external preparation having a low irritation and good usability while suppressing irritation to the anal mucosa and the like has been disclosed.

  Japanese Patent Application Laid-Open No. 2010-284519 (Patent Document 3) includes a skin-side support having transparency, an intermediate base, and a clothes-side support, and the intermediate base is water, a polymer compound, and volatilization. It is a cooling sheet used by sticking to clothing characterized by containing a sexual substance (menthol), and said clothing side support has at least an adhesive layer and a moisture permeation prevention layer, and in particular, a volatile material The content of is more preferably 0.01% by mass to 1.0% by mass, and thereby, it is excellent in refreshing feeling and cooling effect, can suppress the generation of pain due to refreshing feeling, and feel in use. Further, a cooling sheet that is used by being attached to the inside of a garment that is also excellent is disclosed.

  In JP-A-8-283147 (Patent Document 4), an aqueous adhesive base containing a cross-linked product of polyacrylic acid and polyacrylate is blended with a cooling agent (1-menthol) and essential oils. It is an aqueous pressure-sensitive adhesive composition characterized in that the mixing ratio of the refreshing agent and the essential oils is 1: 0.1 to 10 as a weight ratio, and the refreshing agent is 0. 0 of the entire composition. 001% to 5%, and thereby, when applied to the skin as an external preparation, has an effect of obtaining a moderate and durable refreshing feeling without causing skin pain or redness. Is disclosed.

  Japanese Patent Publication No. 2000-505095 (Patent Document 5) discloses a water-based skin cosmetic containing a water-insoluble powder having an average particle size of 0.1 to 50 μm, water, and further a cooling sensation agent (1-menthol). In addition, it is disclosed that when applied to wet skin after bathing or after showering, the skin can have an excellent skin care effect for a long time.

  JP-A-11-209262 (Patent Document 6) discloses (A) low-strength agar, (B) a water-soluble polymer, (C) a cooling sensation agent (menthols), and (D) a topical skin containing water. In particular, a cooling sensation agent is blended in an amount of 0.001 to 10% by weight, and thereby, an effect of having a high cooling effect and a cooling sensation and excellent in stability is disclosed.

  Japanese Patent Laid-Open No. 2001-181120 (Patent Document 7) is characterized by containing ethanol and water as main solvents and blending menthols, camphors and a plant extract having a blood circulation promoting action. Disclosed is an external preparation for skin, particularly containing 0.01 to 10% of menthols, thereby increasing the refreshing feeling and sustainability, and further obtaining an excellent external skin application. Has been.

Japanese Patent No. 3908275 Japanese Patent Application Laid-Open No. 2003-55193 JP 2010-284519 A specification Japanese Patent Laid-Open No. 8-283147 JP 2000-505095 specification JP-A-11-209262 Japanese Patent Application Laid-Open No. 2001-181120

In general, menthol is a colorless crystalline solid at room temperature having a melting point of about 41 ° C. to about 45 ° C. and a boiling point of about 212 ° C. to about 216 ° C., having lipophilicity and poorly soluble in water, alcohols, It has the property of being easily soluble in oils. Therefore, depending on the type and content ratio of the medium component contained together with menthol, the form of dissolution, dispersion, and loading of menthol varies. For example, when the menthol-soluble component and menthol-insoluble water are mixed as a medium component to contain a mixed medium component, the menthol content ratio relative to the mixed medium component, the menthol-soluble component content ratio and the menthol-insoluble water content ratio, etc. The menthol is dissolved in the medium component, or the menthol is precipitated in a solid state in the medium component to be dispersed.
In the above-mentioned conventional menthol-containing refreshing sensation composition or refreshing sensation patch, menthol is contained together with a water component, and menthol is dissolved in a medium component, or menthol is a medium. The state of inclusion of menthol, such as a state of being dispersed in a medium component in a solid form without dissolving in the component, is not clearly disclosed. In addition, the refreshing mechanism of menthol is not clearly disclosed.

  The present invention relates to a refreshing sensation external composition, in which (a) menthol is dissolved in the medium component, (b) menthol is dispersed in the medium component, and (c) menthol is supported on the medium component. It has been found that depending on the menthol-containing state such as, and the like, there is a difference in the action that the human body feels a refreshing feeling or cooling feeling.

  The refreshing sensation external composition of the present invention contains at least (a) menthol and (b) a medium component, (b) a state in which the menthol is dissolved in the medium component, and (b) the menthol is the medium. Among (i) sweat water supplied from the human skin and (ii) moisture adhering to the human skin surface. The human body exhibits an effect of feeling a refreshing sensation or a cooling sensation by the interaction between at least one water component of the menthol and the menthol.

  Preferably, the medium component is a liquid medium component, and the menthol is contained in a state dissolved in the liquid medium component.

  Desirably, in the refreshing sensation external composition, the medium component contains at least an alcohol capable of dissolving the menthol, and the menthol is contained in a state dissolved in the alcohol. To do.

Preferably, the medium component contains at least glycerin capable of dissolving the menthol, and the menthol is contained in a state dissolved in the glycerin.

  Preferably, the medium component contains at least a menthol-soluble surfactant capable of dissolving the menthol, and the menthol is contained in a state dissolved in the medium component.

  Preferably, the medium component contains at least one of ethanol and isopropyl alcohol capable of dissolving the menthol, and at least one of glycol and glycerin capable of dissolving the menthol, and the menthol is the medium. It is contained in a state dissolved in a component, and the medium component does not contain water.

  Desirably, in the refreshing sensation external composition, the medium component does not contain water, and the menthol is contained in a state dissolved in the medium component.

The medium component contains at least a menthol-soluble surfactant capable of dissolving the menthol,
The menthol is contained in a state dissolved in the menthol-soluble surfactant.

  Desirably, the medium component contains at least an alcohol capable of dissolving the menthol and water incapable of dissolving the menthol, such that the menthol is dissolved in the medium component. The menthol, the alcohols, and the water are contained.

  Preferably, the medium component has at least an action of preventing precipitation of the menthol in a mixed medium of alcohols capable of dissolving the menthol, water incapable of dissolving the menthol, and the alcohols and the water. The menthol, the alcohols, the water, and the surfactant in such a ratio that the menthol is dissolved in the medium component. It is characterized by.

  Preferably, the medium component contains at least a menthol-soluble surfactant capable of dissolving the menthol and water incapable of dissolving the menthol, and the menthol is contained in a state dissolved in the medium component. It is characterized by.

  Preferably, the medium component is a liquid medium component, and the menthol is contained in the liquid medium component in a state of being dispersed in the refreshing sensation external composition.

Preferably, in the refreshing external composition, the medium component contains at least a menthol alcohol solution in which the menthol is dissolved and water that does not dissolve the menthol, and the menthol is precipitated and dispersed in the medium component. It is characterized by being contained.

  Desirably, the medium component contains at least a menthol / surfactant solution in which the menthol is dissolved and water that does not dissolve the menthol, and the menthol is contained in a state of being precipitated and dispersed in the medium component. It is characterized by that.

  Desirably, the composition further comprises (e) a transdermally absorbable medicinal component, and the transdermally absorbable medicinal component is contained in a state dissolved or precipitated and dispersed in the medium component.

  Preferably, the transdermally absorbable medicinal component is at least one antipyretic anti-inflammatory agent selected from the group consisting of indomethacin, dichlorophenac, flurbiprofen, ketoprofen and lidocaine, and the transdermally absorbable medicinal component is It is characterized by being contained in a state dissolved or precipitated and dispersed in a medium component.

  Preferably, the medium component contains at least a nanosized silica ultrafine particle powder and a liquid medium component, and at least a part of the menthol is supported on the nanosized silica ultrafine particle powder, and the nanosized silica ultrafine particle supporting the menthol is supported. Fine particle powder is contained in a state dispersed in the liquid medium.

Preferably, the medium component is a solid powder, and the menthol is contained in a state of being supported on the medium component of the solid powder.

  Desirably, in the refreshing sensation external composition, the medium component contains at least a powder having an average particle size of 0.01 to 100 μm, and at least a part of the menthol is contained in a state of being supported on the powder. It is characterized by.

  Desirably, the refreshing sensation external composition is in the form of a powder.

  Desirably, the refreshing sensation imparting external composition does not contain a refreshing sensation imparting agent and a refreshing sensation imparting additive other than menthol, and the menthol content is 0.0001 to 1% by weight based on the total composition amount. It is characterized by being.

  The refreshing patch of the present invention is a gel-like second composition containing the refreshing topical composition containing menthol dissolved in the medium component, and (c) water and a water-soluble polymer. A refreshing gel composition comprising a medium component, and a planar thin base material, wherein the menthol is dissolved in the medium component and contained in the refreshing feel external composition. And the gel-like second medium component are contained in a state of being dissolved, mixed or dispersed with each other, and the refreshing gel composition is attached to the planar substrate, and (i) supplied from human skin The human body feels a refreshing feeling or a cool feeling by the interaction between the menthol and at least one water component of the perspiration water and (ii) water adhering to the human skin surface.

  Desirably, in the above-mentioned refreshing patch, the adhesive composition containing a refreshing external composition not containing water, and (d) a non-aqueous adhesive medium component containing a non-aqueous adhesive substance; And the menthol is contained in a state dissolved in the medium component, and the refreshing sensation external composition and the non-aqueous adhesive medium component are dissolved, mixed or mixed with each other. It is contained in a dispersed state, and the adhesive composition is attached to the planar substrate, and includes (i) sweat water supplied from human skin and (ii) moisture attached to the human skin surface. The human body has an effect of feeling a refreshing feeling or a cool feeling by an interaction between at least one water component and the menthol.

  Another patch for imparting a refreshing feeling of the present invention is a gel-like composition containing a refreshing feeling imparting external composition containing the menthol dispersed in the medium component, and (c) water and a water-soluble polymer. A refreshing sensation imparting gel composition containing a second medium component, and a planar thin base material, the menthol being contained in a state dispersed in the medium component, and the refreshing sensation imparting external use The composition and the gel-like second medium component are contained in a state of being mixed or dispersed with each other, and the refreshing feeling gel composition is attached to the planar substrate, and (i) supplied from human skin The human body feels a refreshing feeling or a cool feeling by the interaction between the menthol and at least one water component of the perspiration water and (ii) water adhering to the human skin surface.

  Still another refreshing sensation patch of the present invention comprises the refreshing sensation external composition containing menthol dissolved or precipitated and dispersed in the medium component, and (e) a transdermally absorbable medicinal component. And (c) a gel-like second medium component containing water and a water-soluble polymer, and a refreshing sensation imparting gel composition and a planar thin base material, wherein the percutaneously absorbable medicinal component Is contained in the state of being dissolved or precipitated and dispersed in the medium component of the refreshing feeling imparting external composition, and the refreshing feel imparting external composition and the gel-like second medium component are dissolved and mixed with each other Or it is the structure contained in the disperse | distributed state, and the said refreshing sensation imparting gel composition was adhere | attached on the said planar base material, (i) The sweat water supplied from a human body skin, and (ii) the water | moisture content adhering to a human body skin surface At least one water component of , By interaction with the menthol, together with the human body performing an operation feel coolness or coldness, characterized in that to achieve the efficacy further due to the percutaneous absorption medicinal components.

  Preferably, the percutaneously absorbable medicinal component is at least one antipyretic anti-inflammatory agent selected from the group consisting of indomethacin, dichlorophenac, flurbiprofen, ketoprofen and lidocaine.

  The refreshing feeling imparting method of the present invention comprises the refreshing feel imparting external composition comprising: (i) a human skin that sweats after exercise, after bathing or after heat generation; or (ii) a human skin to which moisture is attached. It is characterized by being applied to the surface of

  In another refreshing feeling imparting method of the present invention, the refreshing patch is applied to (i) a human skin sweating after exercise, after bathing, or after fever, or (ii) moisture. It is affixed on the surface of human skin.

  The method for producing a refreshing sensation external composition according to the present invention comprises the interaction of menthol with at least one water component of (i) sweat water supplied from human skin and (ii) water adhering to the human skin surface. A method for producing a refreshing sensation-providing external composition that exhibits a refreshing feeling or cooling sensation in the human body, wherein (I) menthol dissolution is performed by dissolving menthol in a liquid medium component capable of dissolving menthol. And (II) at least water that cannot dissolve menthol, a menthol-soluble surfactant that can dissolve menthol, and an action that prevents precipitation of the menthol in a mixed medium of the alcohol and the water. At least one medium component of the precipitation-preventing surfactant and the menthol solution, wherein the menthol is the medium component Were mixed in a ratio such that the dissolved state, the menthol and having a preparing a menthol mixture composition in a state of being dissolved in the medium components.

  Preferably, in place of the step (II), (II-a) at least the menthol solution and water as a medium component insoluble in menthol are mixed, and the menthol is precipitated and dispersed in the medium component. Preparing a menthol mixed composition in a finished state.

  Another method for producing a refreshing sensation external composition of the present invention is as follows: (i) sweat water supplied from human skin and (ii) at least one water component of water adhering to the human skin surface and menthol. A method for producing a refreshing sensation-providing external composition in which a human body feels a refreshing sensation or cooling sensation by action, wherein (Ib) transdermal is obtained by dissolving menthol and a transdermally absorbable medicinal component in a liquid medium component A menthol / percutaneous absorbable medicinal component dissolving step for preparing a menthol solution containing an absorbable medicinal component, and (II-b) at least water insoluble in menthol, a menthol-soluble surfactant capable of dissolving menthol, and , At least one medium component of a precipitation-inhibiting surfactant that acts to prevent precipitation of the menthol in a mixed medium of the alcohol and the water; Menthol solution is mixed to prepare a menthol / transdermal absorbable medicinal component mixture composition in which the menthol and the transdermal absorbable medicinal component are dissolved or precipitated and dispersed in the medium component It is characterized by that.

  According to another aspect of the present invention, there is provided a method for producing a refreshing sensation external composition comprising (i) sweat water supplied from human skin and (ii) at least one water component of water adhering to the human skin surface and menthol. A method for producing a refreshing sensation-providing external composition in which a human body feels a refreshing feeling or a cooling sensation by interaction, and (I) prepares a menthol solution by dissolving menthol in a liquid medium component capable of dissolving menthol Menthol dissolving step, (III) adding and mixing powder to the menthol solution to prepare a menthol solution impregnated powder impregnated with the menthol solution, and (IV) dissolving the menthol from the menthol solution impregnated powder. And a step of removing a medium component to prepare a menthol-supported powder supporting menthol.

  Another method for producing a refreshing sensation external composition of the present invention is as follows: (i) sweat water supplied from human skin and (ii) at least one water component of water adhering to the human skin surface and menthol. A method for producing a refreshing sensation-providing external composition in which the human body feels a refreshing feeling or a cooling sensation by action, wherein (I) menthol is dissolved in a liquid medium component capable of dissolving menthol to prepare a menthol solution A menthol dissolution step, (III) a step of preparing a menthol solution-impregnated powder impregnated with the menthol solution by adding and mixing nano-sized silica fine particle powder to the menthol solution, and (IV) the menthol solution-impregnated powder and others Preparation of a refreshing external composition in which the other liquid medium component and the menthol solution-impregnated powder are uniformly mixed. That step, characterized by having a city.

  The method for producing a refreshing patch according to the present invention comprises (i) sweat water supplied from human skin and (ii) at least one water component of water adhering to the human skin surface, and interaction with menthol. Is a method for producing a refreshing sensation patch having the effect of feeling a refreshing feeling or a cooling sensation, comprising: (I) a menthol dissolving step of preparing a menthol solution by dissolving menthol in a liquid medium component capable of dissolving menthol; (V) Water that cannot dissolve menthol, menthol-soluble surfactant that can dissolve menthol, and anti-precipitation that acts to prevent precipitation of the menthol in a mixed medium of the alcohol and the water At least one medium component of the surfactant, the menthol solution, and a gel-like second medium component containing water and a water-soluble polymer. And a step of preparing a refreshing feeling gel composition in a state where the menthol is dissolved or precipitated and dispersed in the medium component, and (VI) the refreshing feeling imparting gel composition on a flat thin substrate. And a step of attaching.

  Another method for producing the refreshing patch of the present invention is the interaction between menthol and at least one water component of (i) sweat water supplied from human skin and (ii) water adhering to the human skin surface. Is a method for producing a refreshing sensation patch in which the human body feels a refreshing sensation or a cooling sensation, wherein (Ia) menthol and transdermal absorbable medicinal component are dissolved in a liquid medium component, Menthol medicinal ingredient dissolving step for preparing a skin-absorbing medicinal ingredient-containing solution, (V-a) menthol-insoluble water, menthol-soluble menthol-soluble surfactant, and the alcohols and the water And at least one medium component of a precipitation-inhibiting surfactant that prevents the precipitation of the menthol in a mixed medium with the menthol and transdermal absorption medicine A mixed solution, a gel-like second medium component containing water and a water-soluble polymer, and the menthol and the transdermally absorbable medicinal component dissolved or precipitated and dispersed in the medium component And (VI-a) a step of adhering the refreshing gel composition to a flat thin substrate.

In the present invention, “(b) menthol dissolved in liquid medium component” means that menthol is dissolved in the liquid mixed medium component even if the medium component is a liquid mixed medium component in which a plurality of types of liquid media are mixed. It means the form that exists in the state.
In addition, "(b) menthol is precipitated and dispersed in the liquid medium component" means that menthol is dissolved in a menthol-soluble solvent, and then the menthol solution in which the menthol is dissolved is mixed with a menthol-insoluble solvent that does not dissolve other menthol. In this case, a part of the dissolved menthol component becomes insoluble and precipitates, which means a form existing in a dispersed state in the liquid mixed medium.
In addition, “(c) menthol supported on a medium component” means, for example, that an inorganic powder or a porous powder is constituted as a medium component, and menthol is solid on the surface of the inorganic powder or pores of the porous powder. The form which exists in the state hold | maintained and carried in the state is meant.

[Effect A]: containing at least (a) menthol and (b) medium component, (b) a state in which the menthol is dissolved in the medium component, and (b) a state in which the menthol is dispersed in the medium component Or (c) when the refreshing sensation-providing external composition comprising the menthol carried on the medium component is applied to the skin of a human body, the menthol contained in the refreshing sensation-providing external composition, It has some interaction with (i) sweat water supplied from the human skin and (ii) at least one water component adhering to the surface of the human skin, and this interaction causes sensory nerves scattered in the human skin. The cold receptor is stimulated, and the human body feels a refreshing or cool feeling. In particular, the interaction between menthol and the water component suppresses unpleasant sensations that cause pain due to the strong stimulation of menthol, and the refreshing refreshment with less pain sensation during the presence of water components on the human skin surface. A feeling of feeling and coolness lasts.
As sweat water supplied from the human skin, sweat can be applied after exercise, bathing or after fever. As the moisture adhering to the human skin surface, the moisture adhering to the human skin with a shower or wet towel can be applied.
In particular, it is better to apply a refreshing external composition to human skin that is sweating after exercise, bathing, or after fever, rather than skin that has been wet with wet towels. The above effects can be obtained. This is due to the fact that the cold receptor of the human body is significantly stimulated in the state of sweating such as after exercise, bathing or after fever.

[Effect B]: In particular, the refreshing external composition having a state in which the medium component is a liquid medium component and the menthol is dissolved in the liquid medium component exhibits the above-described effects and particularly pains. Unpleasant irritation is further suppressed and the refreshing refreshing and cooling sensation is prolonged even when water is not present on the skin surface, as well as while the water component is present on the human skin surface. Lasts for hours.
This is because when the refreshing external composition is applied to the human skin in which the water component is present, the dissolved menthol concentration is reduced by mixing the water and the liquid medium component while the water component is present. This is because the stimulating action of menthol on the sensory nerve's cold receptor is relaxed and the unpleasant sensation of feeling pain is suppressed, and a refreshing refreshing feeling and cooling feeling with less pain sensation can be obtained. In particular, an unpleasant pain sensation due to a strong stimulation of menthol immediately after the refreshing feel-imparting external composition is applied to human skin is suppressed, and a refreshing refreshing feeling or cooling feeling is obtained. While sweat remains on the human skin and menthol and liquid medium components are present on the human skin surface, the refreshing refreshing feeling and cooling feeling with less pain sensation are maintained. In addition, even in a state in which sweat does not come out after the application of the external composition, menthol remains on the skin surface in a dissolved state in the liquid medium component, so that the menthol stimulating action on the skin is alleviated. A refreshing refreshing sensation and a cool sensation with little pain sensation persist.
In this way, an unpleasant pain sensation due to a strong stimulation of menthol immediately after the refreshing sensation external composition is applied to the human skin is suppressed, and a refreshing refreshing sensation or cooling sensation is obtained, and a water component is added to the human skin surface. As long as the water is present, of course, a refreshing refreshing sensation with a little pain sensation and a cooling sensation persist for a long time even when water is no longer present.

[Effect C]: The refreshing sensation-providing external composition having a state in which the medium component is the liquid medium component and the menthol is precipitated and dispersed in the liquid medium component exhibits the above-described effects. Unpleasant irritation such as pain is alleviated and suppressed, and while moisture is present on the human skin surface, a refreshing refreshing feeling or cooling feeling is maintained for a long time even when moisture disappears. continue.
This is because when the composition for applying a refreshing sensation is applied to the surface of the human skin where moisture is present, the concentration of the precipitated dispersion menthol is reduced by mixing the moisture and the liquid medium component while sweating. This is because the stimulating action of menthol on the cold receptor of sensory nerves in human skin is alleviated and the unpleasant sensation of feeling pain is suppressed, so that a refreshing refreshing feeling and cooling feeling with less pain sensation can be obtained. In particular, an unpleasant pain sensation due to a strong stimulation of menthol immediately after the refreshing feel-imparting external composition is applied to human skin is suppressed, and a refreshing refreshing feeling or cooling feeling is obtained. While moisture remains in the human skin and menthol and liquid medium components are present on the human skin surface, this refreshing refreshing feeling and cooling feeling with less pain sensation is maintained. In addition, menthol is deposited on the liquid medium component and remains on the skin surface in a dispersed state even in a state in which moisture does not remain after the application of the composition for external use. A refreshing refreshing sensation with a little pain sensation and a cool sensation lasts for a long time.
However, in this case, since menthol is precipitated and dispersed in a mixture of sweat and liquid medium components, the precipitated and dispersed menthol directly exerts a stimulating effect on the cold sensory sensory sensory nerve. Therefore, the pain suppressing effect that relieves the unpleasant sensation of feeling this pain tends to be slightly inferior to the aforementioned “state in which menthol is dissolved in the liquid medium component”.

[Effect D]: The refreshing external composition containing the medium component in the state where the medium component is a solid powder and the menthol is supported on the medium component of the solid powder exhibits the above-described effects. Unpleasant irritation such as pain is alleviated and suppressed, and while the moisture is present in the human skin, a refreshing refreshment and cooling feeling can be maintained for a long time even when moisture is absent. continue.
This is because, when the refreshing external composition is applied to the human skin where moisture is present, while the moisture is present, the solid powder carrying menthol is mixed with the moisture to be carried on the powder. As the concentration of menthol is reduced, the menthol's stimulating effect on the cold receptors of sensory nerves in the human skin is relaxed, and the unpleasant sensation of pain is suppressed, resulting in a refreshing refreshing feeling and cooling feeling with less pain sensation Because. In particular, an unpleasant pain sensation due to a strong stimulation of menthol immediately after the refreshing feel-imparting external composition is applied to human skin is suppressed, and a refreshing refreshing feeling or cooling feeling is obtained. While moisture remains in the human skin and menthol and liquid medium components are present on the human skin surface, this refreshing refreshing feeling and cooling feeling with less pain sensation is maintained. In addition, even when no moisture exists after the application of the composition for external use, menthol remains on the skin surface in a state of being supported on the powder, so that the menthol stimulating action on the skin is alleviated. A refreshing and cool feeling with little pain sensation lasts for a long time.
However, in this case, since the menthol is in a state of being carried in the powder, the carried menthol exerts a direct stimulating action on the cold receptor of the sensory nerve of the human skin, and therefore, the unpleasant sensation that feels this pain The pain-suppressing effect of alleviating the above tends to be slightly inferior to the above-mentioned “state where menthol is dissolved in the liquid medium component” and “state where menthol is precipitated and dispersed in the medium component”.

  [Effect E]: (a) The refreshing sensation-providing external composition in which the menthol is dissolved in the medium component; (c) a gel-like second medium component containing water and a water-soluble polymer; A refreshing gel composition and a flat thin substrate, and the menthol is dissolved in the medium component, and the refreshing external composition and the gel-like composition are contained. The cooling medium-improving patch, which is contained in a state of being dissolved, mixed or dispersed with respect to the second medium component and has the configuration in which the cooling-sensitizing gel composition is attached to the planar substrate, is applied to the human skin. Since the same effect as [Effect B] described above is achieved, and further, the refreshing sensation imparting external composition and the gel-like second medium component are contained in a dissolved, mixed or dispersed state, Dissolved in refreshing external composition And are menthol component comes out bleeding to gradually surface of the patch over a long period of time. The exuded menthol exerts a stimulating action over a long time on the cold receptor of the sensory nerve of the human skin, so that a refreshing refreshing feeling and cooling feeling with little pain sensation lasts for a long time.

  [Effect F]: (b) The refreshing sensation external composition in which the menthol is precipitated and dispersed in the medium component, and (c) a gel-like second medium component containing water and a water-soluble polymer. A refreshing gel composition and a flat thin substrate, and the menthol is dispersed in the medium component, and the refreshing external composition and the gel. The second medium component is contained in a state of being mixed or dispersed with each other, and the refreshing patch having the structure in which the refreshing gel composition is attached to the planar substrate is applied to the human skin. At the same time, the same effect as [Effect C] described above is obtained, and further, the refreshing feel imparting external composition and the gel-like second medium component are contained in a state of being mixed or dispersed with each other. Deposited and dispersed in the composition for external use That menthol component comes out bleeding to gradually surface of the patch over a long period of time. The exuded menthol exerts a stimulating action over a long time on the cold receptor of the sensory nerve of the human skin, so that a refreshing refreshing feeling and cooling feeling with little pain sensation lasts for a long time.

  [Effect G]: (b) The state in which the menthol is dissolved in the medium component, (b) The state in which the menthol is precipitated and dispersed in the medium component, or (c) The menthol is in the medium component. A refreshing sensation-providing external composition contained in a supported state, wherein (i) human skin sweating after exercise, bathing or after fever, or (ii) human skin surface to which moisture is attached The same effect as [Effect A], [Effect B], [Effect C], or [Effect D] described above can be obtained by the method for imparting a refreshing feeling applied to. In particular, after exercise, bathing, or after fever, there is more sweating and the sweat is supplied to the skin surface, so the interaction between the sweat and menthol becomes even more pronounced, and these effects are more pronounced. can get.

  [Effect H]: The above-mentioned refreshing patch is applied to (i) the human skin that is sweating after exercise, bathing or after fever, or (ii) the surface of human skin to which moisture is attached. The same effect as [Effect E] or [Effect F] described above can be obtained by the refreshing feeling imparting method. In particular, after exercise, bathing or after fever, there is more sweating and the sweat is supplied to the skin surface, so the interaction between the sweat and menthol is further promoted and these effects are more pronounced Is obtained.

  [Effect 1]: (I) A menthol dissolving step of preparing a menthol solution by dissolving menthol in a liquid medium component capable of dissolving menthol, and (II) at least of water as a medium component and a surfactant. By mixing at least one and the menthol solution to prepare a menthol mixed composition in a state where the menthol is dissolved in the medium component. In addition to the above, it is possible to obtain a refreshing sensation-providing external composition dissolved in a medium component without precipitation of menthol, and thus, a refreshing sensation-providing external composition capable of exhibiting the above-mentioned [Effect B]. can get.

  [Effect J]: (I) A menthol dissolution step of preparing menthol solution by dissolving menthol in a liquid medium component capable of dissolving menthol, and (III) nano-sized silica fine particle powder or average particle 0 in the menthol solution. A step of preparing a menthol solution-impregnated powder impregnated with the menthol solution by adding 0.01 to 100 μm powder, and (IV) removing the menthol-soluble medium component from the menthol solution-impregnated powder, According to the method for producing a refreshing sensation-providing external composition having a step of preparing a supported menthol-supported powder, a powder that efficiently supports menthol can be obtained, and thereby, the above-mentioned [Effect D] can be exhibited. A refreshing external composition can be obtained.

  [Effect K]: (I) A menthol dissolving step of preparing a menthol solution by dissolving menthol in a liquid medium component capable of dissolving menthol, and (V) at least one of the menthol solution, water, and a surfactant. A refreshing sensation gel in which one medium component and a gel-like second medium component containing water and a water-soluble polymer are mixed, and the menthol is dissolved or precipitated and dispersed in the medium component. A cooling sensation in which menthol is dissolved by a method for producing a cooling sensation imparting patch comprising: a step of preparing a composition; and (VI) a step of attaching the refreshing sensation imparting gel composition to a flat thin substrate. While being able to obtain a gel composition, the coolness imparting patch which can exhibit the above-mentioned [effect E] is obtained by this.

  [Effect L]: The refreshing sensation-providing external composition having a constitution in which the medium component does not contain water and the menthol is contained in a state dissolved in the medium component exhibits the above-mentioned [Effect B]. In particular, when the refreshing external composition is applied to the skin where the moisture of the human body exists, while the moisture is present, the concentration of the dissolved menthol is reduced by mixing the moisture and the liquid medium component. This is because the stimulating action of menthol on the cold receptor of the sensory nerves of the skin is alleviated and the unpleasant sensation of feeling pain is suppressed, so that a refreshing refreshing feeling and cooling feeling with less pain sensation can be obtained. In particular, an unpleasant pain sensation due to a strong stimulation of menthol immediately after the refreshing feel-imparting external composition is applied to human skin is suppressed, and a refreshing refreshing feeling or cooling feeling is obtained.

  [Effect M]: A refreshing sensation external composition containing menthol dissolved in a medium component and not containing water, and (d) a non-aqueous adhesive medium component containing a non-aqueous adhesive substance. The pressure-sensitive adhesive composition to be contained and the flat thin base material are contained, and the menthol is contained in a state dissolved in the medium component, and the refreshing sensation imparting external composition and the non-aqueous pressure-sensitive adhesive medium component are The refreshing patch, which is contained in a dissolved, mixed or dispersed state and has a configuration in which the pressure-sensitive adhesive composition is attached to the planar substrate, exhibits the above-mentioned [Effect L] action and effects. Can be maintained for a long time.

  [Effect N]: The medium component contains at least a nanosized silica ultrafine particle powder and a liquid medium, and at least a part of menthol is supported on the nanosized silica ultrafine particle powder, and nanosized silica ultrafine particle powder supporting menthol. In the composition for providing a refreshing sensation contained in a state dispersed in a liquid medium, the nano-sized silica ultrafine particle powder can efficiently support menthol on its high specific surface area, which is remarkably excellent as described above. The effect [effect D] is obtained. In particular, since the nano-sized silica ultrafine particle powder supporting menthol is contained in a state dispersed in a liquid medium, it is unpleasant due to a strong irritation of menthol immediately after the refreshing external composition is applied to the human skin. The pain sensation is remarkably suppressed, and a refreshing refreshing feeling and cooling feeling are obtained, and the refreshing refreshing feeling and cooling feeling are maintained for a long time.

  [Effect O]: A medium component contains at least glycerin capable of dissolving menthol, and the menthol is contained in a state of being dissolved in the medium component, or a refreshing sensation external composition, or the medium component dissolves at least menthol. A composition for providing a refreshing sensation, comprising at least one of ethanol and isopropyl alcohol capable of dissolving menthol and at least one of glycol and glycerin capable of dissolving menthol, wherein menthol is dissolved in the medium component. In the product, glycol or glycerin can dissolve menthol and also has a moisturizing effect to moisturize the human skin. Further, since it has a high boiling point, evaporation is suppressed even after being applied to the human skin. An unpleasant pain sensation due to a strong stimulus is remarkably suppressed, and an exhilarating refreshing feeling or cooling feeling is obtained. Rutotomoni, the exhilarating sensation of coolness and cold feeling is maintained for a long time.

[Effect P]: In addition to menthol, the refreshing sensation external composition or the refreshing sensation patch further containing a transdermally absorbable medicinal component is the above-mentioned [Effect A], [Effect B] corresponding to the structure. ], [Effect C], [Effect E], or [Effect F], and exhibits the medicinal effects caused by the contained transdermally absorbable medicinal ingredients.
In particular, as a percutaneously absorbable medicinal component, a refreshing sensation external composition or a refreshing sensation patch containing an antipyretic anti-inflammatory agent such as indomethacin, dichlorophenac, flurbiprofen, ketoprofen, lidocaine, etc. A refreshing sensation and cooling sensation are obtained, and an excellent antipyretic and anti-inflammatory effect is obtained. Since both menthol and these antipyretic anti-inflammatory agents are present in a dissolved state in the liquid medium, the effect of effectively promoting penetration of the anti-pyretic anti-inflammatory agent into the skin is exhibited.

  The refreshing sensation external composition of the present invention contains at least (a) menthol and (b) a medium component, (b) a state in which the menthol is dissolved in the medium component, and (b) the menthol is the medium. A state in which the menthol is deposited and dispersed in the component, or (c) the menthol is supported on the medium component, and (i) sweat water supplied from the human skin and (ii) moisture adhering to the human skin surface. The human body has an effect of feeling a refreshing feeling or a cooling sensation due to an interaction between at least one of the water components and the menthol.

  As sweat water supplied from human skin, sweat water that is scratched after exercise, after bathing or after fever can be applied. The moisture adhering to the human skin surface is not particularly limited, and for example, moisture adhering to the human skin with a shower or wet towel, moisture remaining on the skin after wiping off the sweat water, and the like can be applied.

  As menthol, menthol derivatives such as l-menthol, dl-menthol and 1-menthyl glyceryl ether can be used.

  In particular, a configuration in which the medium component is a liquid medium component and menthol is dissolved in the liquid medium component is desirable. Examples of the liquid medium component capable of dissolving menthol include alcohols, surfactants capable of dissolving menthol, and other solvents that are harmless to the human body.

  Alcohols that can dissolve menthol are not particularly limited, but include, for example, ethanol, isopropyl alcohol, ethylene glycol, glycerin, other lower alcohols, and capryl alcohol, lauryl alcohol, stearyl alcohol, oleyl alcohol, linoleyl alcohol, Other higher alcohols can be used. Menthol is dissolved in these alcohols at room temperature or in a heated state to prepare a menthol alcohol solution.

  The menthol-soluble surfactant capable of dissolving menthol is not particularly limited. For example, polysorbate 80 (polyoxyethylene sorbitan oleate), polysorbate 60 (polyoxyethylene sorbitan stearate), polysorbate 20 (polyoxy laurate) Polysorbates such as ethylene sorbitan) can be used. Menthol is dissolved in these polysorbates at room temperature or in a heated state to prepare a menthol polysorbate solution.

While stirring the menthol / alcohol solution described above, water is gradually added and mixed until the menthol is dissolved in the alcohol / water mixture until just before the menthol is precipitated and dispersed. A sensation-providing external composition is obtained.
In addition, while stirring the menthol / alcohol solution described above, water is gradually added and mixed. After the menthol is precipitated and dispersed, and further water is added, a part of the menthol becomes alcohol / water. A refreshing sensation-providing external composition is obtained in which the menthol is dissolved in the liquid mixture and the remainder of the menthol is precipitated and dispersed in the alcohol / water liquid mixture.
While stirring the above menthol / alcohol solution, water is gradually added and mixed, and the menthol in a mixed medium of alcohol and water is added to the menthol / alcohol / water mixed solution in which menthol is precipitated and dispersed. By adding an anti-deposition surfactant that acts to prevent the precipitation of menthol, the menthol is dissolved again, and the menthol is dissolved in an alcohol / water / surfactant mixed solution to provide a refreshing sensation-providing external composition. can get. This is due to the fact that menthol can be dissolved in the alcohol / water mixture by the action of the surfactant.

  The state in which menthol is dissolved in the medium component or the state in which it is precipitated and dispersed is determined by the respective content ratios of menthol, menthol-soluble medium component, and menthol-insoluble water. For example, in the mixed medium component of alcohol and menthol-insoluble water in the menthol-soluble medium component, when the menthol content is small, a predetermined amount of menthol dissolves, and when it exceeds the predetermined amount of menthol, Menthol is deposited and dispersed. Further, when the content ratio of alcohol in the menthol-soluble medium component is larger than that of menthol-insoluble water, more menthol is dissolved.

  While stirring the menthol / surfactant solution described above, water is gradually added and mixed until the menthol is dissolved in the surfactant / water mixture until just before the menthol is precipitated and dispersed. A refreshing sensation-providing external composition can be obtained. In addition, while stirring the menthol / surfactant solution described above, water is gradually added and mixed, beyond the state where menthol is precipitated and dispersed, and then by adding water, a part of the menthol is interfaced. A refreshing sensation-providing external composition is obtained in which the menthol is dissolved in the activator / water mixture and the remaining menthol is precipitated and dispersed in the surfactant / water mixture. Thus, in any composition, menthol is contained in a state where all the menthol is dissolved in the medium component or in a state where a part of the menthol is dissolved in the medium component.

The method for producing a refreshing sensation external composition of the present invention includes (I) a menthol dissolving step of preparing a menthol solution by dissolving menthol in a liquid medium component capable of dissolving menthol, and (II) at least dissolving menthol. Among the impossible water, a menthol-soluble surfactant capable of dissolving menthol, and a precipitation-preventing surfactant having an action of preventing precipitation of the menthol in a mixed medium of the alcohols and the water A menthol mixed composition in which the menthol is dissolved in the medium component by mixing at least one medium component and the menthol solution at a ratio such that the menthol is dissolved in the medium component And a step of preparing. Thereby, the effect of [Effect I] described above can be obtained. Although it does not specifically limit as a liquid medium component which can melt | dissolve menthol, For example, alcohol, such as the above-mentioned ethanol, isopropyl alcohol, glycol, glycerin, can be used.
A menthol mixed composition in which the menthol is dissolved in a mixed solution of a medium component and water is prepared by mixing water in a ratio in which menthol does not precipitate into the menthol solution in which menthol is dissolved.
Further, when a surfactant such as polysorbate capable of dissolving menthol is used as a medium, the menthol solution in which menthol is dissolved, at least one of a surfactant capable of dissolving menthol and water, A menthol mixed composition in a state where the menthol is dissolved in the medium component is prepared by mixing with a menthol solution.

On the other hand, in place of the step (II), (II-a) at least a menthol solution and water as a medium component are mixed, and the menthol mixed composition in a state where menthol is precipitated and dispersed in the medium component A method for producing a refreshing sensation-providing external composition comprising the step of preparing
That is, water is added to and mixed with the menthol solution in which the menthol is dissolved, water is added until the menthol is precipitated and dispersed, and a part of the menthol is mixed in the liquid mixture of the medium component and water. A menthol mixed composition in the state of precipitation dispersion is prepared.

  Further, water is added to and mixed with the menthol solution in which menthol is dissolved, and water is added until the menthol is precipitated and dispersed, and a part of the menthol is precipitated and dispersed in the mixed liquid of the medium component and water. In addition, the menthol that had been dispersed and dispersed was added to the menthol mixture in a state of being added, and further added with a precipitation-inhibiting surfactant that prevents the precipitation of menthol in the mixed medium of the menthol-soluble medium component and water. A menthol mixed composition in a state of being dissolved again in a mixed solution of a medium component, water and a surfactant is prepared.

  The method for imparting a refreshing sensation of the present invention uses a refreshing sensation imparting external composition containing menthol in a state where all menthols are dissolved in a medium component, and (i) after exercise, after bathing, or after heat generation, By applying to the human skin that is sweating, or (ii) the surface of the human skin to which moisture is attached, (i) the sweat supplied from the human skin and (ii) the moisture that adheres to the human skin surface The effect of [Effect B] described above can be obtained by the interaction between at least one water component of menthol and the menthol. In particular, (i) after exercise, after bathing, or after fever), it is possible to obtain a more remarkable [effect B] by applying it to the human skin that is sweating.

  Another cooling feeling imparting method of the present invention uses a refreshing feeling imparting external composition in which menthol is contained in a state in which a part of menthol is dissolved in the medium component and the remaining menthol is precipitated and dispersed in the medium component. Due to the interaction of the menthol with at least one water component of sweat water supplied from the human skin and water adhering to the human skin surface, (i) sweating after exercise, after bathing or after fever At least one of (i) sweat water supplied from the human skin and (ii) moisture adhering to the human skin surface by applying to the human skin, or (ii) the human skin surface adhering to the water Due to the interaction between the water component and the menthol, the effect of [Effect C] described above can be obtained. In particular, by applying (i) after exercise, bathing, or) fever to human skin that is sweating, a more remarkable [effect C] can be obtained.

  As sweat water supplied from human skin, sweat water that is scratched after exercise, after bathing or after fever can be applied. The moisture adhering to the human skin surface is not particularly limited, and for example, moisture adhering to the human skin with a shower or wet towel, moisture remaining on the skin after wiping off the sweat water, and the like can be applied. The human skin to which the refreshing sensation external composition is applied is not particularly limited. For example, a part where a lot of perspiration such as chest, neck, shoulders, back and arms is particularly desirable.

In the refreshing sensation external composition of the present invention, a configuration in which the medium component is a solid powder and menthol is contained in a state of being supported on the medium component of the solid powder can also be implemented. Using such a refreshing external composition containing a solid powder carrying menthol, at least one of (i) sweat water supplied from human skin and (ii) water adhering to the human skin surface The effect of [Effect D] described above is obtained by the interaction between the two water components and the menthol. In particular, (i) by applying to sweating human skin after exercise, after bathing or after fever, a more remarkable effect of [Effect D] can be obtained.
The solid powder is not particularly limited. For example, inorganic powders such as talc, mica, silica, zinc oxide, sericite, kaolin, and magnesium oxide, and silicone resin, polyethylene resin, polystyrene resin, polyester resin, etc. Synthetic polymer powder can be used.
As the size of the powder, a powder having an average particle size of 0.01 to 100 μm is desirable. When the average particle size is less than 0.01 μm, the amount of menthol supported is small, and the effect of obtaining a refreshing feeling tends to decrease. In addition, when the average particle size exceeds 100 μm, when the powder-containing refreshing sensation-providing external composition is applied to human skin, there is a tendency for unpleasant sensation such as roughness to occur.
Thus, a menthol is contained in a state of being supported on a medium component of a solid powder, and a refreshing sensation imparting external composition in a powder form is used.

  It does not contain a refreshing sensation imparting agent and a refreshing sensation imparting additive other than menthol, and the content of menthol is preferably in the range of 0.0001 to 1% by weight with respect to the total composition amount. A range of 0.5% by weight is desirable. When the menthol content is less than 0.0001% by weight, the effect of obtaining a refreshing feeling is reduced, and when the menthol content exceeds 1% by weight, it is applied to the human skin that is sweating. In this case, as the content of menthol increases, the effect of suppressing pain tends to be slightly inferior.

In the refreshing sensation external composition of the present invention, the medium component contains at least a nanosized silica ultrafine particle powder and a liquid medium, and at least a part of menthol is supported on the nanosized silica ultrafine particle powder. A configuration in which size silica ultrafine particle powder is contained in a dispersed state in a liquid medium can also be implemented.
Nano-sized silica ultrafine particle powder is agglomerated particles are formed having a three-dimensional structure is a bulky powder transient particle size 5 nm to 50 nm, BET method specific surface area of ^{50m 2} / ^g~500m 2 / g, the hydrophilic nano There are a silica ultrafine particle powder and a hydrophobic nano-sized silica ultrafine particle powder. For example, a trade name “Aerosil” manufactured by Nippon Aerosil Co., Ltd. is applied. In a composition containing water as a liquid medium, the inclusion of hydrophilic nanosized silica ultrafine powder is desirable, and in a composition containing a lipophilic solvent as a liquid medium, the inclusion of hydrophobic nanosized silica ultrafine powder is desirable. desirable. With this configuration, the above-described [Effect N] effect can be obtained, and the nano-sized silica ultrafine particle powder supporting menthol is contained in a dispersed state in a liquid medium. Immediately after the composition for external use is applied to human skin, the unpleasant pain sensation due to the strong stimulation of menthol is remarkably suppressed, and a refreshing refreshing feeling and cooling feeling are obtained, and the refreshing refreshing feeling and cooling feeling are maintained for a long time. The

  The refreshing sensation-providing external composition containing the nano-sized silica ultrafine particle powder comprises (I) a menthol dissolution step of preparing menthol solution by dissolving menthol in a liquid medium component capable of dissolving menthol, and (III) Adding a nano-sized silica fine particle powder to the menthol solution to prepare a menthol solution-impregnated powder impregnated with the menthol solution; and (IV) mixing the menthol solution-impregnated powder and another liquid medium component, Preparing a refreshing sensation-providing external composition in which the other liquid medium component and the menthol solution-impregnated powder are uniformly mixed.

  The refreshing feeling imparting patch of the present invention comprises a refreshing feel imparting external composition containing the above menthol dissolved in a liquid medium component, and (c) a gel-like second medium component containing a water-soluble polymer. And a refreshing gel composition containing a flat thin substrate, and menthol is contained in a state dissolved in a liquid medium component, and a refreshing feel external composition and a gel-like composition are included. The two-medium component is contained in a state of being dissolved, mixed or dispersed with each other, and the refreshing sensation imparting gel composition is attached to the planar substrate, and the patch is (i) after exercise, after bathing, Or by applying it to the human skin that is sweating after fever, or (ii) the surface of the human skin to which moisture has adhered, and (ii) the sweat supplied from the human skin and (ii) the surface of the human skin At least one of the adhering moisture A component, by interaction with the menthol, are obtained operations and effects of the aforementioned [Effect E]. In particular, (i) A more remarkable [Effect E] can be obtained by applying to sweating human skin after exercise, bathing, or fever.

  The method for producing a refreshing patch according to the present invention comprises (i) sweat water supplied from human skin and (ii) at least one water component of water adhering to the human skin surface, and interaction with menthol. Is a method for producing a refreshing sensation patch having the effect of feeling a refreshing feeling or a cooling sensation, comprising: (I) a menthol dissolving step of preparing a menthol solution by dissolving menthol in a liquid medium component capable of dissolving menthol; (V) Water that cannot dissolve menthol, menthol-soluble surfactant that can dissolve menthol, and anti-precipitation that acts to prevent precipitation of the menthol in a mixed medium of the alcohol and the water At least one medium component of the surfactant, the menthol solution, and a gel-like second medium component containing water and a water-soluble polymer. And a step of preparing a refreshing feeling gel composition in a state where the menthol is dissolved or precipitated and dispersed in the medium component, and (VI) the refreshing feeling imparting gel composition on a flat thin substrate. And a step of attaching.

  The gel-like second medium component containing water and a water-soluble polymer is not particularly limited. For example, a polyacrylic acid aqueous solution in which a water-soluble polymer such as polyacrylic acid is dissolved in water is used. Further, by adding a crosslinking agent, a water-containing gel-like composition of crosslinked polyacrylic acid can be obtained. Further, a hydrous gel as described in JP-A-2007-29606 and a gel body as described in Utility Model Registration No. 3087211 are used, specifically, polyacrylic acid, polyacrylic A gel-like component mainly composed of a crosslinked product such as an acid salt or a natural polymer, and other hydrous gel-like components are used. Further, the flat thin substrate is not particularly limited. For example, a flat thin substrate of a fiber structure such as a nonwoven fabric, a woven fabric, or paper as described in JP-A-2007-29606 is used. Is done.

  This refreshing patch provides (I) a menthol dissolving step of preparing a menthol solution by dissolving menthol in a menthol-soluble medium component capable of dissolving menthol, and (V) menthol, water incapable of dissolving menthol. And at least one medium component of a menthol-dissolving surfactant capable of dissolving the menthol, and an anti-deposition surfactant having an action of preventing precipitation of the menthol in a mixed medium of the alcohols and the water The menthol solution is mixed with a gel-like second medium component containing water and a water-soluble polymer, and the menthol is dissolved or precipitated and dispersed in the medium component. It is manufactured by a process comprising a step of preparing a composition, and a step (VI) of attaching the refreshing sensation imparting gel composition to a planar thin substrate. Thereby, the effect of [Effect K] described above is obtained.

  The other refreshing patch of the present invention contains a menthol dissolved in a medium component and contains a water-free refreshing external composition, and (d) a non-aqueous adhesive substance containing a non-aqueous adhesive substance. An adhesive composition containing an aqueous adhesive medium component, and a flat thin substrate, and the menthol is contained in a state dissolved in the medium component. The medium component is contained in a state of being dissolved, mixed or dispersed with each other, and the adhesive composition is attached to the planar substrate. The patch is (i) after exercise, after bathing, or after heat generation. When applied to human skin that sweats, or (ii) human skin to which moisture is attached, the human body feels refreshed or cool due to the interaction between the sweat component supplied from the human skin and menthol. Have the effect of feeling And features. Thereby, the effect of [Effect M] described above is obtained.

Non-aqueous adhesive medium components containing non-aqueous adhesive substances include non-aqueous adhesive rubber components such as acrylic rubber, nitrite rubber, styrene-butadiene rubber, other synthetic rubbers, and natural rubber as the main component. A composition is used. Further, the flat thin substrate is not particularly limited. For example, a flat thin device of a fiber structure such as a nonwoven fabric, a woven fabric, or a paper as described in JP-A-2007-29606 is used. The
The human skin to which the water-based or non-water-based refreshing patch is applied is not particularly limited, but, for example, a place where a lot of sweat such as chest, shoulder, back, and arm is particularly desirable.

In the above-mentioned composition for providing refreshing sensation, the composition further comprises (e) a transdermally absorbable medicinal component, and the transdermally absorbable medicinal component is contained in a state dissolved or precipitated and dispersed in a medium component. Can also be implemented.
This refreshing sensation external composition comprises (Ib) menthol / percutaneous absorbable medicinal component in which menthol and a transdermal absorbable medicinal component are dissolved in a liquid medium component to prepare a transdermal absorbable medicinal component-containing menthol solution Dissolution step, and (II-b) at least water in which menthol cannot be dissolved, menthol-soluble surfactant capable of dissolving menthol, and precipitation of the menthol in a mixed medium of the alcohol and the water. The menthol solution is mixed with at least one medium component of the anti-deposition surfactant having an effect of preventing the menthol solution, and the menthol and the transdermally absorbable medicinal component are dissolved or precipitated and dispersed in the medium component. And a step of preparing a mixed composition of menthol and transdermally absorbable medicinal components.

In the above-mentioned refreshing sensation patch, the above-described refreshing sensation external composition, (e) a transdermally absorbable medicinal component, (c) a gel-like second medium component containing water and a water-soluble polymer, Comprising a gel composition containing a refreshing sensation and a planar thin substrate, wherein the percutaneously absorbable medicinal component is dissolved or precipitated and dispersed in the medium component of the refreshing sensation external composition. And the gel-like second medium component is contained in a state of being dissolved, mixed or dispersed with each other, and the gel-feeling gel composition is contained in the planar substrate. A configuration attached to the can also be implemented.
This refreshing sensation patch comprises (Ia) a menthol medicinal component dissolving step of dissolving menthol and a transdermal absorbable medicinal component in a liquid medium component to prepare a menthol / transdermal absorbable medicinal component-containing solution, (Va) Water that cannot dissolve menthol, menthol-soluble surfactant that can dissolve menthol, and precipitation that has the effect of preventing precipitation of the menthol in a mixed medium of the alcohol and the water Mixing at least one medium component of the inhibitory surfactant, the menthol / transdermally absorbable medicinal component-containing solution, and a gel-like second medium component containing water and a water-soluble polymer, A step of preparing a refreshing sensation imparting gel composition in which the menthol and the transdermally absorbable medicinal component are dissolved or precipitated and dispersed in the medium component; and (VI-a) a flat thin substrate. A step of attaching the cooling sensation imparted gel composition is prepared by a process comprising a.

  The percutaneously absorbable medicinal component is not particularly limited, for example, antipyretic agent, anti-inflammatory agent, analgesic agent, moisturizer, itching inhibitor, dandruff inhibitor, suppuration agent, athlete's foot treatment agent such as ringworm fungus, ultraviolet ray inhibitor, Etc. can be used. In particular, the transdermally absorbable medicinal component is at least one antipyretic anti-inflammatory agent selected from the group consisting of indomethacin, dichlorophenac, flurbiprofen, ketoprofen and lidocaine, and the transdermally absorbable medicinal component is included in the medium component. It is desirable that the composition is contained in a dissolved state or a precipitated and dispersed state. Thereby, the above-mentioned [Effect P] operational effect is obtained.

  Specific examples of the present invention will be described below, but the present invention is not limited to the following examples. In this example, 1-menthol is used as menthol, but not limited thereto, menthol derivatives such as dl-menthol and 1-menthyl glyceryl ether can also be used.

Example 1.
Using glycerin and ethanol as medium components, 90 g of ethanol is mixed with 10 g of glycerin in which 0.005 g of menthol is dissolved to prepare a transparent liquid refreshing imparting external composition A in which menthol is dissolved.

Example 2
In a mixed medium component of 50 g of ethylene glycol and 50 g of isopropyl alcohol, 0.005 g of menthol is dissolved to prepare a transparent liquid refreshing imparting external composition B in which menthol is dissolved.

Example 3
A 0.1% potassium hydroxide aqueous solution is added to and mixed with 10 g of glycerin in which 0.005 g of menthol is dissolved to prepare a refreshing sensation external composition C containing menthol.

Example 4
(I) preparing a menthol solution by dissolving 0.003 g of menthol in a mixture of 20 g of glycerin as a menthol-soluble medium component capable of dissolving menthol and 70 g of ethanol; and (II) as a medium component in the menthol solution. And a step of mixing 10 g of purified water, a transparent liquid refreshing external composition D in which menthol is dissolved is prepared.

Example 5 FIG.
(I) a step of dissolving 0.003 g of menthol in a mixture of 10 g of glycerin and 60 g of ethanol as a menthol-soluble medium component capable of dissolving menthol, and (II-a) a medium in the menthol solution A step of mixing 15 g of purified water as a component and 15 g of polyoxyethylene sorbitan oleate as a surfactant while being a medium component, and preparing a transparent liquid refreshing external composition E in which menthol is dissolved Is done.

Example 6
(I) a step of dissolving 0.003 g of menthol in a mixture of 20 g of glycerin and 70 g of ethanol as a menthol-soluble medium component capable of dissolving menthol, and (II-b) a medium in the menthol solution A transparent liquid refreshing external composition F in which menthol is dissolved is prepared by mixing 15 g of purified water as a component and a moisturizing agent as a transdermally absorbable medicinal component.

Example 7
Polyoxyethylene sorbitan oleate as a surfactant capable of dissolving menthol, mixed liquid medium component of 10 g of glycerin, 40 g of ethanol and 40 g of purified water, 10 g of polyoxyethylene sorbitan oleate in which 0.005 g of menthol was dissolved, Are mixed to prepare a transparent liquid refreshing external composition G in which menthol is dissolved.

Example 8 FIG.
As a surfactant capable of dissolving menthol, polyoxyethylene sorbitan oleate is used, and 40 g of polyoxyethylene sorbitan oleate in which 0.0001 g of menthol is dissolved and 60 g of purified water are mixed to form a transparent liquid in which menthol is dissolved. A refreshing feel-applied external composition H is prepared.

Example 9
0.01 g of menthol is dissolved in a mixed liquid medium component of 10 g of glycerin and 20 g of ethanol, and then 70 g of purified water is added to and mixed with the menthol / glycerin / ethanol solution so that part of the menthol is precipitated and dispersed. A refreshing sensation external composition I is prepared.

Example 10
Using polyoxyethylene sorbitan oleate as a surfactant capable of dissolving menthol, 80 g of purified water is mixed with 20 g of polyoxyethylene sorbitan oleate dissolved with 0.0005 g of menthol, and a part of menthol is precipitated and dispersed. The white turbidity-state refreshing external composition J is prepared.

Example 11
(I) a menthol dissolving step of preparing menthol solution by dissolving 0.01 g of menthol in 10 g of glycerin as a menthol-soluble medium component capable of dissolving menthol, and (III) nano-sized silica fine particle powder in the menthol solution And (IV) a step of preparing a menthol solution-impregnated powder impregnated with the menthol solution by adding 1 g of hydrophilic aerosil 200 (trade name, manufactured by Nippon Aerosil Co., Ltd., BET specific surface area 200 square meters / g) as By mixing the menthol solution impregnated powder with 20 g of polyoxyethylene sorbitan oleate as a surfactant and 70 g of ethanol as another liquid medium component, the other liquid medium component and the menthol solution impregnated powder are made uniform. A mixed refreshing external composition K is prepared.

Example 12
(I) A menthol dissolving step of preparing menthol solution by dissolving 0.002 g of menthol in 1 g of medium component ethanol capable of dissolving menthol, and (III) adding 60 g of talc powder having an average particle size of 2 μm to the menthol solution. A menthol-impregnated powder impregnated with the menthol solution; and (IV) removing the ethanol from the menthol-impregnated powder by evaporation by a vacuum drying method to prepare a menthol-supported powder supporting menthol A powdery composition is prepared by the step of performing. In addition, in order to improve the touch feeling of the powdery composition or to adjust the menthol-containing concentration, it is possible to add a step of adding 40 g of silicone powder having an average particle size of 10 μm to this composition. It is. In this way, a powdery refreshing external composition L is prepared.

Example 13
(I) A menthol dissolution step of preparing a menthol solution in which menthol is dissolved in a medium component by the same method as in the above-described Examples 1 to 8, (V) the menthol solution, and purified water as a medium component Mixing a polyacrylic acid that is a water-soluble polymer as a second medium component to prepare a refreshing gel composition in which menthol is dissolved in the medium component; and (VI) stretchable A cooling sensation imparting patch is prepared by attaching a predetermined amount of the refreshing sensation gel composition to a flat thin substrate made of a polyester fiber nonwoven fabric. Further, the polyacrylic acid is cross-linked into a gel state by chemical treatment of the cross-linking reaction before or after the step (VI). In the step (V), (V) the step of mixing the menthol solution, purified water as a medium component, and polyacrylic acid, which is a water-soluble polymer as a second medium component, includes the menthol solution It is also possible to mix the polyacrylic acid aqueous solution, thereby preparing a refreshing feeling gel composition in a state where menthol is dissolved in the medium component. By adhering to the thin substrate, a refreshing imparting patch M is prepared. The menthol is contained in a state dissolved in the medium component, and the refreshing sensation-providing external composition and the gel-like second medium component are contained in a state of being dissolved, mixed or dispersed with each other.
In addition, content of each component of a medium component, purified water, and a water-soluble polymer so that menthol content contained in a refreshing imparting gel composition may be 0.001 to 0.5 weight%. Is controlled and prepared.

Example 14
(I) A menthol dissolution step of preparing a menthol precipitation dispersion solution in which menthol is precipitated and dispersed in the medium component by the same method as in Examples 9 and 10, and (V) the menthol precipitation dispersion solution and the medium component A step of mixing purified water and polyacrylic acid, which is a water-soluble polymer as the second medium component, to prepare a refreshing gel composition in a state where menthol is precipitated and dispersed in the medium component; ) A refreshing feeling patch is prepared by attaching a predetermined amount of the refreshing gel composition to a flat thin substrate made of a stretchable polyester fiber nonwoven fabric. Further, the polyacrylic acid is cross-linked into a gel state by chemical treatment of the cross-linking reaction before or after the step (VI).
In this manner, a refreshing feeling patch N is prepared. The menthol is contained in a state in which the menthol is precipitated and dispersed in the medium component, and the refreshing sensation-providing external composition and the gel-like second medium component are contained in a state of being dissolved, mixed, or dispersed.
In addition, content of each component of a medium component, purified water, and water-soluble polymer so that menthol content contained in a refreshing feeling imparting gel composition may be 0.001 to 0.5 weight%. Is controlled and prepared.

Example 15.
A menthol solution in which menthol is dissolved in the medium component is prepared by the same method as in Example 1 to Example 8, and a non-aqueous adhesive medium component containing a non-aqueous adhesive substance such as acrylic rubber or styrene-butadiene rubber is used. The above menthol solution is mixed to prepare an adhesive composition, and a predetermined amount of the adhesive composition is attached to a flat thin substrate made of a stretchable polyester fiber nonwoven fabric with a thickness of 1 to 5 mm.
In this way, a refreshing feeling patch O is prepared. The menthol is contained in a state of being dissolved in the medium component, and the refreshing sensation external composition and the non-aqueous adhesive medium component are contained in a state of being dissolved, mixed or dispersed with each other.
In addition, content of each component of a medium component, purified water, and water-soluble polymer so that menthol content contained in a refreshing feeling imparting gel composition may be 0.001 to 0.5 weight%. Is controlled and prepared.

Example 16
In each of Examples 1 to 10 described above, indomethacin as an antipyretic anti-inflammatory agent was further added and contained at a ratio of 1% by weight with respect to the refreshing external composition, A refreshing sensation imparting external composition P is prepared.

Example 17.
(Ib) Menthol and transdermal absorbability in the liquid medium component using the liquid medium component of Example 1 to Example 10 described above and using indomethacin having antipyretic anti-inflammatory effect as a transdermal absorbable medicinal component A menthol / percutaneous absorbable medicinal component dissolving step for dissolving a medicinal component to prepare a transdermally absorbable medicinal component-containing menthol solution; and (II-b) at least water that cannot dissolve menthol and menthol can be dissolved Menthol-soluble surfactant, and at least one medium component of a precipitation-inhibiting surfactant that acts to prevent precipitation of the menthol in a mixed medium of the alcohols and the water, and the menthol solution Menthol and transdermal absorbable drug in a state in which the menthol and the transdermally absorbable medicinal component are dissolved or precipitated and dispersed in the medium component Preparing a component mixture composition, coolness imparted external composition P is manufactured by.
Moreover, it replaces with indomethacin, and each refreshing feeling imparting external composition P containing dichlorophenac, flurbiprofen, ketoprofen, or lidocaine is manufactured.

Example 18
(Ia) Menthol and transdermal absorbability in liquid medium component using liquid medium component of above-mentioned Example 1 to Example 10 and using indomethacin having antipyretic anti-inflammatory effect as transdermal absorbable medicinal component Menthol medicinal ingredient dissolving step for dissolving medicinal ingredient to prepare menthol / transdermal absorbable medicinal ingredient containing solution, (Va) menthol / percutaneously absorbable medicinal ingredient containing solution, and menthol cannot be dissolved Water, menthol-soluble surfactant capable of dissolving menthol, and at least one precipitation-preventing surfactant having an action of preventing precipitation of the menthol in a mixed medium of the alcohol and the water Two medium components and a gel-like second medium component containing water and a water-soluble polymer are mixed, and the menthol and the transdermally absorbable medicinal component are dissolved in the medium component. The step of preparing a refreshing feeling gel composition in the state of being deposited or dispersed and the step of (VI-a) attaching the refreshing feeling imparting gel composition to a planar thin base material Patch Q is manufactured.
Moreover, each refreshing patch Q containing dichlorophenac, flurbiprofen, ketoprofen, or lidocaine is produced instead of indomethacin.

Example 19.
The liquid refreshing feeling imparting composition, the powdery refreshing feel imparting composition, and the refreshing imparting patch are (i) human skin sweating after exercise, after bathing, after fever, or the like, or (Ii) Used by being applied or affixed to the surface of human skin to which moisture is attached. For example, it is applied or affixed to the chest, back, etc. where sweat is high.

  When the refreshing sensation-providing external composition or the refreshing sensation-applying patch of the present invention is applied to or pasted on the human skin, the menthol contained in the refreshing sensation-providing external composition is applied to the surface of sweat and human skin supplied from the human skin. It interacts with at least one water component of the adhering water, and this interaction stimulates the cold receptors of sensory nerves scattered in the human skin, and the human body feels a refreshing or cool feeling. An effect is produced. In particular, the interaction between menthol and the sweat component suppresses the unpleasant sensation of feeling pain due to the strong stimulation of menthol, and the refreshing refreshing feeling and cooling feeling with less pain sensation continue throughout the sweat. To do.

Claims (34)

Containing at least (a) menthol and (b) a medium component;
(B) The menthol is dissolved in the medium component, (b) The menthol is precipitated and dispersed in the medium component, or (c) The menthol is supported on the medium component. ,
(I) Sweat water supplied from the human skin and (ii) At least one water component of water adhering to the human skin surface and the menthol interact with the human body to feel a refreshing or cool feeling. A composition for providing a refreshing sensation, characterized in that the composition is played.   The refreshing sensation-providing external composition according to claim 1, wherein the medium component is a liquid medium component, and the menthol is contained in a state dissolved in the liquid medium component. The medium component contains at least an alcohol capable of dissolving the menthol,
The refreshing sensation imparting external composition according to claim 2 or 3, wherein the menthol is contained in a state dissolved in the alcohol. The medium component contains at least glycerin capable of dissolving the menthol,
The menthol is contained in a state dissolved in the glycerin, and the refreshing sensation imparting external composition according to claim 2 or 3. The medium component contains at least one of ethanol and isopropyl alcohol capable of dissolving the menthol, and at least one of glycol and glycerin capable of dissolving the menthol,
The refreshing sensation-providing external composition according to claim 2 or 3, wherein the menthol is contained in a state dissolved in the medium component. The medium component does not contain water,
6. The refreshing sensation external composition according to claim 2, wherein the menthol is contained in a state dissolved in the medium component. The medium component contains at least a menthol-soluble surfactant capable of dissolving the menthol,
The said menthol is contained in the state melt | dissolved in the said menthol soluble surfactant, The refreshing feeling provision external composition of Claim 2 characterized by the above-mentioned. The medium component contains at least an alcohol that can dissolve the menthol, and water that cannot dissolve the menthol,
3. The refreshing sensation external composition according to claim 2, wherein the menthol, the alcohols, and the water are contained in such a ratio that the menthol is dissolved in the medium component. . The medium component has at least an effect of preventing precipitation of the menthol in a mixed medium of alcohols capable of dissolving the menthol, water incapable of dissolving the menthol, and the alcohols and the water. An active surfactant,
The refreshment according to claim 2, wherein the menthol, the alcohols, the water, and the surfactant are contained at a ratio such that the menthol is dissolved in the medium component. Sensitive external composition. The medium component contains at least a menthol-soluble surfactant that can dissolve the menthol, and water that cannot dissolve the menthol,
The refreshing sensation-providing external composition according to claim 2, wherein the menthol is contained in a state dissolved in the medium component.   2. The refreshing sensation external composition according to claim 1, wherein the medium component is a liquid medium component, and the menthol is contained in a state of being precipitated and dispersed in the liquid medium component. The medium component contains at least a menthol alcohol solution in which the menthol is dissolved, and water that does not dissolve the menthol,
12. The refreshing sensation external composition according to claim 11, wherein the menthol is contained in a state of being precipitated and dispersed in the medium component. The medium component contains at least a menthol / surfactant solution in which the menthol is dissolved, and water that does not dissolve the menthol,
12. The refreshing sensation external composition according to claim 11, wherein the menthol is contained in a state of being precipitated and dispersed in the medium component. Furthermore, (e) contains a transdermally absorbable medicinal component,
The refreshing sensation external composition according to any one of claims 1 to 13, wherein the transdermally absorbable medicinal component is contained in a state dissolved or precipitated and dispersed in the medium component. The transdermally absorbable medicinal component is at least one antipyretic anti-inflammatory agent selected from the group consisting of indomethacin, dichlorophenac, flurbiprofen, ketoprofen and lidocaine,
The composition for external application of refreshing feeling according to claim 14, wherein the transdermally absorbable medicinal component is contained in a state dissolved or precipitated and dispersed in the medium component. The medium component contains at least nano-sized silica ultrafine powder and a liquid medium component,
At least a part of the menthol is supported on the nanosize silica ultrafine powder,
2. The refreshing sensation external composition according to claim 1, wherein the nanosize silica ultrafine particle powder supporting the menthol is contained in a state dispersed in the liquid medium component.   2. The refreshing sensation external composition according to claim 1, wherein the medium component is a solid powder and the menthol is contained in a state of being supported on the medium component of the solid powder. The medium component contains at least a powder having an average particle size of 0.01 to 100 μm,
2. The refreshing sensation external composition according to claim 1, wherein at least a part of the menthol is contained in a state of being supported on the powder.   The composition for external application of refreshing feeling according to claim 17 or 18, wherein the composition is in a powder form. Does not contain a refreshing agent other than menthol and a refreshing additive,
The refreshing sensation-providing external composition according to any one of claims 1 to 19, wherein the menthol content is 0.0001 to 1% by weight based on the total amount of the composition. A refreshing sensation imparting gel composition containing the refreshing sensation imparting external composition according to any one of claims 2 to 10, and (c) a gel-like second medium component containing water and a water-soluble polymer,
A planar thin substrate, and
The menthol is contained in a state dissolved in the medium component, and the refreshing sensation external composition and the gel-like second medium component are contained in a state of being dissolved, mixed or dispersed with each other,
The refreshing gel composition is a structure attached to the planar substrate,
(I) Sweat water supplied from the human skin and (ii) At least one water component of water adhering to the human skin surface and the menthol interact with the human body to feel a refreshing or cool feeling. A patch for imparting a refreshing sensation characterized by the performance. The adhesive composition containing the refreshing sensation imparting external composition according to claim 6 and further comprising (d) a non-aqueous adhesive medium component containing a non-aqueous adhesive substance,
A planar thin substrate, and
The menthol is contained in a state dissolved in the medium component,
The refreshing sensation-providing external composition and the non-aqueous adhesive medium component are contained in a dissolved, mixed or dispersed state,
The pressure-sensitive adhesive composition is attached to the planar substrate;
(I) Sweat water supplied from the human skin and (ii) At least one water component of water adhering to the human skin surface and the menthol interact with the human body to feel a refreshing or cool feeling. A patch for imparting a refreshing sensation characterized by the performance. A refreshing sensation imparting gel composition comprising the refreshing sensation imparting external composition according to any one of claims 11 to 13, and (c) a gel-like second medium component containing water and a water-soluble polymer,
A planar thin substrate, and
The menthol is contained in a state dispersed in the medium component,
The refreshing sensation-providing external composition and the gel-like second medium component are contained in a mixed or dispersed state,
The refreshing gel composition is a structure attached to the planar substrate,
(I) Sweat water supplied from the human skin and (ii) At least one water component of water adhering to the human skin surface and the menthol interact with the human body to feel a refreshing or cool feeling. A patch for imparting a refreshing sensation characterized by the performance. A refreshing sensation-providing external composition according to any one of claims 1 to 13, (e) a transdermally absorbable medicinal component, (c) a gel-like second medium component containing water and a water-soluble polymer, A refreshing gel composition containing
A planar thin substrate, and
The transdermally absorbable medicinal component is contained in a state dissolved or precipitated and dispersed in the medium component of the refreshing sensation external composition,
The refreshing sensation-providing external composition and the gel-like second medium component are contained in a dissolved, mixed or dispersed state,
The refreshing gel composition is a structure attached to the planar substrate,
(I) Sweat water supplied from the human skin and (ii) At least one water component of water adhering to the human skin surface and the menthol interact with the human body to feel a refreshing or cool feeling. A patch for imparting a refreshing sensation characterized by exhibiting an effect due to the percutaneously absorbable medicinal component.   The refreshing sensation according to claim 24, wherein the transdermally absorbable medicinal component is at least one antipyretic anti-inflammatory agent selected from the group consisting of indomethacin, dichlorophenac, flurbiprofen, ketoprofen and lidocaine. Giving patch.   21. The refreshing sensation external composition according to any one of claims 1 to 20, wherein (i) human skin sweating after exercise, after bathing or after heat generation, or (ii) human body to which moisture is attached A method for imparting a refreshing sensation, comprising applying to the surface of the skin.   26. The refreshing patch according to any one of claims 21 to 25, wherein (i) a human skin sweating after exercise, bathing or after fever, or (ii) a human body to which moisture is attached A method for imparting a refreshing sensation, characterized by being applied to the surface of the skin. A refreshing effect that the human body feels a refreshing feeling or a cool feeling due to the interaction between (i) sweat water supplied from the human skin and (ii) at least one water component adhering to the human skin surface and menthol. A method for producing a sensitizing external composition comprising:
(I) a menthol dissolving step of preparing a menthol solution by dissolving menthol in a liquid medium component capable of dissolving menthol;
(II) At least water that cannot dissolve menthol, menthol-soluble surfactant that can dissolve menthol, and precipitation that has the effect of preventing precipitation of the menthol in a mixed medium of the alcohol and water. The menthol is dissolved in the medium component by mixing at least one medium component of the preventive surfactant and the menthol solution at a ratio such that the menthol is dissolved in the medium component. Preparing a menthol mixed composition in a prepared state;
A method for producing a refreshing sensation-providing external composition, comprising: Instead of the step (II),
(II-a) A step of mixing at least the menthol solution and water as a medium component incapable of dissolving menthol to prepare a menthol mixed composition in a state where the menthol is precipitated and dispersed in the medium component. ,
The method for producing a refreshing sensation-providing external composition according to claim 28, comprising: A refreshing effect that the human body feels a refreshing feeling or a cool feeling due to the interaction between (i) sweat water supplied from the human skin and (ii) at least one water component adhering to the human skin surface and menthol. A method for producing a sensitizing external composition comprising:
(Ib) a menthol / percutaneous absorbable medicinal component dissolution step of preparing a transdermal absorbable medicinal component-containing menthol solution by dissolving menthol and the transdermal absorbable medicinal component in a liquid medium component;
(II-b) At least an action that prevents precipitation of the menthol in a mixed medium of the water in which menthol cannot be dissolved, menthol-soluble surfactant capable of dissolving menthol, and the alcohols and water. Menthol in a state where the menthol and the transdermally absorbable medicinal component are dissolved or deposited and dispersed in the medium component by mixing at least one medium component of the anti-deposition surfactant having the effect and the menthol solution. A step of preparing a transdermally absorbable medicinal component mixture composition;
A method for producing a refreshing sensation-providing external composition characterized by comprising: A refreshing effect that the human body feels a refreshing feeling or a cool feeling due to the interaction between (i) sweat water supplied from the human skin and (ii) at least one water component adhering to the human skin surface and menthol. A method for producing a sensitizing external composition comprising:
(I) a menthol dissolving step of preparing a menthol solution by dissolving menthol in a liquid medium component capable of dissolving menthol;
(III) adding and mixing powder to the menthol solution to prepare a menthol solution-impregnated powder impregnated with the menthol solution;
(IV) removing the menthol-soluble medium component from the menthol solution-impregnated powder to prepare a menthol-supported powder supporting menthol;
A method for producing a refreshing sensation-providing external composition characterized by comprising: A refreshing effect that the human body feels a refreshing feeling or a cool feeling due to the interaction between (i) sweat water supplied from the human skin and (ii) at least one water component adhering to the human skin surface and menthol. A method for producing a sensitizing external composition comprising:
(I) a menthol dissolving step of preparing a menthol solution by dissolving menthol in a liquid medium component capable of dissolving menthol;
(III) adding and mixing nano-sized silica fine particle powder to the menthol solution to prepare a menthol solution-impregnated powder impregnated with the menthol solution;
(IV) A step of preparing a refreshing sensation-providing external composition in which the menthol solution-impregnated powder and another liquid medium component are mixed to uniformly mix the other liquid medium component and the menthol solution-impregnated powder.
And a method for producing a refreshing sensation-providing external composition. A refreshing effect that the human body feels a refreshing feeling or a cool feeling due to the interaction between (i) sweat water supplied from the human skin and (ii) at least one water component adhering to the human skin surface and menthol. A method for producing a sensitizing patch,
(I) a menthol dissolving step of preparing a menthol solution by dissolving menthol in a liquid medium component capable of dissolving menthol;
(V) Water that is insoluble in menthol, menthol-soluble surfactant that can dissolve menthol, and anti-precipitation that has the effect of preventing precipitation of the menthol in a mixed medium of the alcohol and the water. The menthol was dissolved in the medium component by mixing at least one medium component of the surfactant, the menthol solution, and a gel-like second medium component containing water and a water-soluble polymer. A step of preparing a refreshing feeling gel composition in a state or in a dispersed state,
(VI) a step of adhering the refreshing sensation imparting gel composition to a planar thin substrate;
A method for producing a refreshing sensation patch, comprising: A refreshing effect that the human body feels a refreshing feeling or a cool feeling due to the interaction between (i) sweat water supplied from the human skin and (ii) at least one water component adhering to the human skin surface and menthol. A method for producing a sensitizing patch,
(Ia) a menthol medicinal component dissolving step of dissolving a menthol and a transdermal absorbable medicinal component in a liquid medium component to prepare a menthol / transdermal absorbable medicinal component-containing solution;
(Va) Water that cannot dissolve menthol, menthol-soluble surfactant that can dissolve menthol, and precipitation that has the effect of preventing precipitation of the menthol in a mixed medium of the alcohol and the water Mixing at least one medium component of the inhibitory surfactant, the menthol / transdermally absorbable medicinal component-containing solution, and a gel-like second medium component containing water and a water-soluble polymer, A step of preparing a refreshing sensation imparting gel composition in which the menthol and the transdermally absorbable medicinal component are dissolved or precipitated and dispersed in the medium component;
(VI-a) a step of attaching the refreshing feeling gel composition to a planar thin substrate;
A method for producing a refreshing sensation patch, comprising: