JP2003070898A - Plaster and production method thereof - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a plaster and a production method thereof which achieves a larger cooling effect and easier production thereof with a simple structure. SOLUTION: A support 12 comprising a fiber layer made of a nonwoven fabric, woven fabric, paper or the like is arranged on one side thereof and a layer of gel 14 made of a water soluble high polymer material containing moisture of 90 wt.% or more is laminated stably on the other side of the support 12. The support 12 comprises a nonwoven fabric made of olefin based fibers, for instance, and a layer of adhesive gel 14 comprising a natural or synthetic water soluble high polymer material is formed on one surface of the nonwoven fabric.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a patch for sticking to an inflamed part of the body when a person has a fever or for moisturizing or refreshing the skin, and a method for producing the patch.
The present invention relates to an anti-inflammatory and analgesic patch, a patch for cooling heads and limbs, a patch used as a cosmetic such as a face mask.

[0002]

2. Description of the Related Art Conventionally, as an adhesive patch or a cooling sheet to be applied to the body, an olefin non-woven fabric coated with an adhesive hydrogel has been widely used. Such a cooling sheet
20-60% of an adhesive such as polyacrylic acid salt and an excipient such as glycerin are mixed. This hydrogel has a three-dimensional network structure formed by a cross-linking reaction of a polyacrylic acid salt and the like, which retains water and is gelated, and has an adhesive property.

[0003]

[Problems to be Solved by the Invention] Here, fever, bruise,
In the treatment of sprains and the like, it is important to cool strongly, but in the case of the above-mentioned conventional adhesive water-containing gel, the water content is 40 to 80% from the problem of the shape retention of the adhesive water-containing gel, There was a limit to the amount of water retained. In addition, adhesive water-containing gels have a slow evaporation rate of water because they are retained by the chemical bonding and interaction of water with the acrylic adhesive, glycerin, and other excipients in the water-containing gel. The amount of evaporation of water decreased with the passage of time, a large amount of water that did not evaporate remained, and the cooling effect was low. Therefore, the amount of evaporation of water is 30 mg / cm ² / h in 2 hours after application.
However, the amount of evaporation decreases with time,
After the lapse of ˜6 hours, it was reduced to 10 to 15 mg / cm ² / h. Also, in order to improve the cooling effect, it is sufficient to increase the water content to increase the water content, but if the water content of the adhesive hydrous gel is increased, the shape retention decreases and the weight becomes heavier, and the adhesiveness drops and drops. Because it will be easier to do
It was difficult to increase the water content to 80% or more.

The present invention has been made in view of the above problems in the prior art, and an object thereof is to provide a patch having a simple structure and a large cooling effect, and a method for producing the same.

[0005]

According to the present invention, a support comprising a fiber layer such as non-woven fabric, woven fabric or paper is provided on one side, and the other side of the support has a water content of 90% by weight or more. It is a patch formed by stably laminating a gel layer of a water-soluble polymer material. The support is made of, for example, a non-woven fabric of olefin fiber, and a gel layer having adhesiveness of a natural or synthetic water-soluble polymer material is formed on one surface of the non-woven fabric.

The gel layer is made of a water-soluble polymer material which is solidified by cooling or a water-soluble polymer material which is solidified by a chemical reaction. Any one of gellan gum, mannan, polyvinylpyrrolidone, gum arabic, gum tragacanth, agar, gelatin, and carboxyl vinyl polymer can be used as a solidifying material upon cooling.
Alternatively, it is composed of a plurality of components. In addition, as a substance that is solidified by a chemical reaction, sodium alginate,
There are polyvinyl alcohol and the like.

Further, 0.1 to 5% of a hydrophilic tackifier may be mixed in the gel layer, and as the hydrophilic tackifier, an acrylic tackifier, polyethylene glycol, polypropylene glycol or the like is used. preferable. Also,
A mixture of 0.1 to 3% humectant may be used. Then, the gel layer is filled and held in the molded mold or covered with a moisture impermeable film.

The gel layer is a poultice containing a drug such as an anti-inflammatory analgesic, a gel having a cooling effect due to evaporation of water, or a cosmetic having a moisturizing effect on the surface of human skin.

Further, the gel layer has elasticity and skin adhesiveness, and further, on the skin-adhering side surface,
A circular or elliptical suction cup-shaped recess may be formed.

Further, according to the present invention, an aqueous solution of a gelling agent of a water-soluble polymer material having a water content of 90% by weight or more is heated to a dissolved state, or in a formulation in which a gel is formed by a chemical reaction, before the gelation, The aqueous solution is poured into a mold having a predetermined shape, and before the aqueous solution is completely gelled in the mold, a support is bonded to the gelling agent aqueous solution or the gelling gel surface in the mold, and the aqueous solution is added. Is a method for producing a patch for gelling.

Further, according to the present invention, the aqueous solution of the gelling agent is evenly spread, and a support is bonded to the aqueous solution of the gelling agent or the surface of the gel that is being gelled before completely gelling, and It is a method for producing a patch, which comprises gelling and cutting the support and the gel into a predetermined shape.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described below with reference to the drawings. 1 to 3 show an embodiment of the present invention, and a patch 10 of this embodiment
Is a support 1 made of a non-woven fabric or a woven fabric composed of hydrophilic fibers or hydrophobic fibers, or a mixed spinning or laminated body of these.
2 is provided. The support has a basis weight of 30 to 100 g / m ² , preferably 50 to 70 g / m ² , and is most preferably a stretchable nonwoven fabric. As the material of the fiber, in addition to polyester, polypropylene, acrylic, etc., a mixed fiber of fibers such as rayon, pulp and cotton may be used. As a result, the water evaporation rate can be increased.

On the opposite surface of the support 12, a water-soluble polymer having a water content of 90 to 99.9% in view of cooling property due to water evaporation, and preferably 94 to 98% in view of adhesiveness and shape retention. The gel 14 of material is present in a stable manner. The water-soluble polymer gelling agent is, for example, one that gels and is solidified by cooling after being melted by heating. Any one or more of gellan gum, mannan, polyvinylpyrrolidone, gum arabic, tragacanth gum, agar, and gelatin can be used. It consists of ingredients. In addition, as a substance that is solidified by a chemical reaction,
Examples include sodium alginate and polyvinyl alcohol.

In the gel 14, a hydrophilic tackifier is added in an amount of 0.
You may mix 1-5%. As a result, the adhesive strength of the adhesive patch 10 during use is prevented from being lowered and the adhesiveness is imparted. The hydrophilic tackifier is preferably an acrylic adhesive, polyethylene glycol, polypropylene glycol, or the like.

Further, in order to improve the gel strength, it is preferable to mix a water-soluble polymer having a hydrophilic group such as a hydroxyl group, an ethylene oxide group or an amide group. In particular, carboxymethyl cellulose having hydroxy group, hydroxyethyl cellulose, starch, xanthan gum, pullulan, polyvinyl alcohol, carboxy vinyl polymer or derivatives thereof can be used.

Further, as a moisturizing agent in the gel 14, glycerin, ethylene glycol, propylene glycol,
1,3-butylene glycol and other polyglycerin can be used. The blending amount of these is 0.1 to 10%, preferably 0.3 to 3% with respect to the gel 14.

In addition, organic acids, oils, surfactants, inorganic powders, inorganic salts, preservatives, pH adjusters, pigments, dyes and the like may be mixed.

Further, the gel 14 is blended with natural menthol, synthetic menthol, other menthol derivatives, plant components such as peppermint oil, chamomile and the like and other essential oil components as a cooling agent to further improve the refreshing and cooling sensations. Can be enhanced. When used as a poultice, an anti-inflammatory analgesic such as methyl salicylate, glycol salicylate, indomethacin may be added.

The gel 14 is placed in a thin resin mold 16 as shown in FIGS. 1 and 2, and the support 1 is placed on the surface side thereof.
2 are laminated, and the gel 14 is covered with the support 12 and the mold 16. In this state, part of the gel 14 is the support 12
It infiltrates inside to form an infiltration layer 14a, the support 12 and the gel 14 are integrated, and the surface area of the gel 14 also increases. The infiltration layer 14a may reach the vicinity of the surface of the support 12, and the cooling effect is higher in that case. The surface of the support 12 is preferably dry, but the gel 14 may further exude to the surface, and a gel layer may be present on the surface side.

Next, a method for manufacturing the patch 10 of this embodiment will be described with reference to FIG. In this manufacture, the film 20 is formed by a blister molding machine, and the mold 16 for containing the gel is formed. And this mold for gel form 1
6 is filled with the gelling agent aqueous solution which has not been solidified by heating dissolution or chemical reaction through the injection pipe 22 or the like. After that, the support 12 is pulled out from the roll of the support 12 (not shown) and superposed on the surface of the gel 14. Then, each patch 10 is punched by a Thomson punching machine or the like, and sealed and packaged.

Next, the operation of the patch 10 of this embodiment will be described. A large amount of water is contained in the gel 14 of the patch 10 in a volatile state, and the water gradually evaporates during use. Water evaporation amount of the patch 10, in the two hours from the time of sticking a ^{50~60mg / cm 2 / h, 30~40mg} / cm 2 / h even after 5-6 hours passed
Water evaporates. When this patch 10 is applied to a human body, the temperature rapidly drops within 5 minutes to about 30 minutes due to heat of vaporization, and the temperature drops by 5 ° C or more. After that, the water content in the gel is almost 1
Evaporation is 00%, and high water evaporation continues for about 8 hours. This significantly lowers the temperature of the skin surface, maintains it for a long time, and effectively suppresses inflammation and the like.

Since the water-containing gel 14, especially the natural polymer gel, has a weak interaction with water, the evaporation rate of water is high due to application, and the water content in the gel evaporates with time, resulting in a decrease in water content. However, a substantially constant amount of water evaporation is maintained. Furthermore, since almost all of the water content contained in the gel 14 evaporates in 6 to 8 hours after application, it exhibits a very high cooling action as compared with the conventional hydrogel containing sodium polyacrylate as an adhesive component.

The patch of the present invention is not limited to the above embodiments, and the support 12 may be paper such as woven cloth, net, Japanese paper, etc. other than non-woven fabric. In addition, the water-soluble polymer gel may have a shape for enhancing the adhesiveness, for example, a suction cup-shaped shallow concave portion is appropriately formed on the surface of the gel 14. This makes it possible to compensate for the decrease in adhesive strength with the suction cup portion.

Further, the method for producing a patch of the present invention is not limited to one in which the gel 14 is put in a mold 16 molded of a resin film and is packaged, but the gel is heated and dissolved in a mold attached to a belt conveyor and circulated. Alternatively, the solution may be filled with an aqueous solution of the agent and covered with the support 12, and after the gel 14 is solidified, the gel is removed from the mold together with the support 12 and then sealed as individual patches. Furthermore, without providing a mold for accommodating the gel, a moisture-impermeable release film is provided on the flat surface, and the gel is cast on the release film to cause gelation together with the support, after which the release film, gel and The support may be cut into an appropriate size and hermetically sealed. In this case, the manufacturing cost is the lowest.

[0025]

EXAMPLE A first example of the present invention will be described. In this example, 1.5 parts of agar, 0.5 part of sodium carboxymethyl cellulose, 1 part of glycerin, 0.1 part of menthol, 2 parts of alcohol, and 94.9 parts of purified water were uniformly mixed and dissolved by heating to form a gel. An aqueous solution of the agent was formed. This aqueous solution was dropped onto a polypropylene film having a thickness of 30 μm so as to have a thickness of 1.5 mm, and a spunbonded non-woven fabric having a basis weight of 60 g / m ² was placed on the polypropylene film to cool it before it gelled. It was cut into a size of × 130 mm and hermetically sealed.

Next, a second embodiment of the present invention will be described. The patch of this example comprises 1.5 parts of agar, 1.5 parts of Nicazole (acrylic adhesive) and 0.1 parts of menthol.
Parts, 2 parts of alcohol and 94.9 parts of purified water were uniformly mixed and dissolved by heating to form an aqueous solution of a gelling agent, and the aqueous solution was filled in a gelling mold. The mold is 150μ thick
The CPP film of m was applied to a blister molding machine to form a container having a length and width of 50 mm × 130 mm and a depth of 3 mm.
18 g of the above aqueous solution was dropped into this mold and filled in the mold,
Before gelling, a spunbonded nonwoven fabric having a basis weight of 60 g / m ² cut into a size of 55 mm × 135 mm was placed, cooled, and hermetically sealed.

As a comparative example of the prior art to be compared with the above examples, 5.5 parts of sodium polyacrylate, 4 parts of polyacrylic acid, 15 parts of glycerin, 6 parts of sorbitol, 3 parts of kaolin, 1 part of tartaric acid and 0 of menthol. 1 part, 0.15 parts of synthetic aluminum silicate, and 65.25 parts of purified water were uniformly mixed, and this mixture was spread on a polyester non-woven fabric (100 g / m ^{2 of} basis weight) at a rate of 0.2 g / cm ^2. Then
A polypropylene film is attached and the length and width are 50 mm x 13
A piece cut into a size of 0 mm was formed.

The measured values of the water evaporation amount of the patches of Examples 1 and 2 above and the water evaporation amount of the above-mentioned comparative example using the conventional adhesive hydrogel are shown below.

[0029]

[Table 1] As can be seen from this Example, since the patch according to the present invention has a high water content, the amount of water vaporized is large and the cooling action is 2-3 in comparison with the conventional cooling sheet of the adhesive hydrous gel.
It can take double the amount of heat. In addition, compared to acrylic adhesives and rubber adhesives, it has less irritation to the skin and higher safety.

[0030]

EFFECT OF THE INVENTION The adhesive patch of the present invention contains a water-soluble polymer or the like containing water at a high rate of 90% or more, and
Moisture evaporates almost completely by sticking. Therefore, the amount of water evaporated per unit time is large and the duration is long. Therefore, this patch can maintain a high cooling effect for a long time. Further, by providing the support, the strength is ensured, the gel having adhesiveness is not exposed, and the moisture evaporation rate is increased due to the increase in the gel surface area. In addition, the gel according to the present invention is less irritating to the skin and has no side effect due to application.

Further, the patch of the present invention is easy to process the shape, is inexpensive in manufacturing cost, has no harmful substances even when it is discarded, and has almost no load on the environment.

[Brief description of drawings]

FIG. 1 is a cross-sectional view of a patch of an embodiment of the present invention.

FIG. 2 is a perspective view showing a mold for gel according to an embodiment of the present invention.

FIG. 3 is a schematic view showing a manufacturing process of the patch of this embodiment.

[Explanation of symbols]

10 patches 12 Support 14 gel Type 16 20 films

Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/48 A61K 9/70 405 9/70 405 47/36 47/36 A61P 17/16 A61L 15/58 29/00 A61P 17/16 C09J 7/02 Z 29/00 201/00 C09J 7/02 A61L 15/01 201/00 15/06 F term (reference) 4C076 AA09 AA75 BB31 CC18 CC19 DD30 DD37 DD38 DD51 EE27 EE30 EE32 EE36 FF04 FF12 FF14 FF17 FF35 FF39 FF57 4C081 AA03 AA12 BA17 BB01 BC02 CA021 CA082 CA182 CA211 CB042 CD012 CD022 CD042 CE02 CE11 DA02 DA12 DC03 DC05 EA02 EE06 4C083 AB051 AC07 AC07 AD1222 AD0511 AD272BB36 AD0511 AA04 AA05 AA08 AA10 AB01 CA02 CA04 CB01 CC04 CC05 CC06 CE01 EA06 FA09 4J040 BA191 DD021 DF002 DH031 GA05 GA22 HA126 HB09 HB10 HB11 KA26 KA39 MA09 MA11 MA15 MB02 NA02

Claims (14)

[Claims] 1. A support comprising a fiber layer is provided on one side, and a gel layer of a water-soluble polymer material having a water content of 90% by weight or more is stably and integrally laminated on the other side of the support. A patch characterized by being formed. 2. The adhesive patch according to claim 1, wherein the gel layer is made of a water-soluble polymer material of a natural polymer polysaccharide that is solidified by cooling. 3. The gel layer is made of a water-soluble polymer material that is solidified by a chemical reaction.
The patch described above. 4. The gel layer is made of a synthetic water-soluble polymer material that solidifies by cooling.
The patch described above. 5. The patch according to claim 1, wherein the support is made of non-woven fabric or woven fabric. 6. The patch according to claim 1, wherein the gel layer has elasticity and skin adhesiveness. 7. The patch according to claim 1, wherein the gel layer is filled and held in a mold formed by molding a film. 8. The adhesive patch according to claim 1, wherein the gel layer is mixed with 0.1 to 5% of a hydrophilic tackifier. 9. The patch according to claim 1, wherein the gel layer is mixed with 0.1 to 3% of a moisturizing agent. 10. The surface of the gel layer on which the skin is attached,
The patch according to claim 1, wherein a suction cup-shaped recess is formed. 11. An aqueous solution of a gelling agent of a water-soluble polymer material having a water content of 90% by weight or more is heated and dissolved, and this aqueous solution is poured into a mold having a predetermined shape, and the aqueous solution is gelled in this mold. A method for producing a patch, comprising the steps of joining a support to the surface of an aqueous solution of a gelling agent in the mold and cooling the solution to gel the aqueous solution. 12. An aqueous solution of a gelling agent of a water-soluble polymer material having a water content of 90% by weight or more is heated and dissolved, and the support is bonded to the aqueous gelling agent solution before the aqueous solution is uniformly spread and gelled. A method for producing a patch, which comprises cooling the aqueous solution to gel, and cutting the support and the gel into a predetermined shape. 13. A water-soluble polymer material having a water content of 90% by weight or more is uniformly spread before solidification by a chemical reaction, a support is bonded to the surface of the water solution, and then the water solution is gelled. A method for producing a patch, which comprises: 14. A water-soluble polymer material having a water content of 90% by weight or more is solidified by a chemical reaction, the aqueous solution is poured into a mold having a predetermined shape, and a support is bonded to the surface of the aqueous solution. A method for producing a patch, comprising gelling an aqueous solution.