JP5497298B2 - Sheet patch - Google Patents

Description

  The present invention relates to a sheet-like patch.

  Sheet patches are typically used as tapes and poultices for the treatment of low back pain, stiff shoulders, bruises, sprains, etc., and healing foot fatigue. It is also used as a sheet pack for beauty purposes, a face mask, a cooling gel sheet, and the like.

  Of these, when the active ingredient-containing layer is composed of an aqueous adhesive layer, the oleophilic active ingredient and its solubilizer are generally bleeded by phase separation or emulsion breakage from the aqueous gel. However, it may be felt as an unpleasant stickiness on the surface of the gel. Further, when the patch is packaged in the bag, the inside of the bag becomes sticky due to bleeding, and there is a problem that the patch is difficult to remove from the bag or torn off when removed from the bag.

  In addition, the sheet-like patch may be wrapped in at least two folds with the release film on the inside, but the folded release films adhere to each other, and when the patch is to be unfolded It may be difficult to peel off, or the release films may be in close contact with each other due to the bleed as described above, making it difficult to deploy, and if it is attempted to deploy forcibly, the adhesive layer and the release film may be separated and become unusable. .

In order to solve such problems, several countermeasures have been proposed in the past.
For example, Patent Document 1 discloses a patch using a release film subjected to double-sided release treatment, and describes that the release film prevents adhesion between patches in a bag. Patent Document 2 discloses a medical patch in which a patch having a pressure-sensitive adhesive layer provided on one side of a support is folded and pasted so as to cover both sides of a separator subjected to double-sided release treatment. . However, the film subjected to the double-sided release treatment is slippery because the release surfaces come into contact with each other in the state of being wound up as a raw material, and needs to be wound around a bobbin type core having a flange in order to maintain the wound shape, etc. Care must be taken in handling the film. Further, in the manufacturing process of the patch, a special device is required for the device so that the release film does not cause a skid at a position where the release film is in contact with the manufacturing device. Furthermore, in the case of the patch of the form as described in Patent Document 2, after the patch is produced, a step of bonding the double-sided release separator and the patch is necessary, and the processing speed is reduced and the cost and defective products are also reduced. There are issues such as rate increase.
Patent Document 3 discloses a drug-containing pressure-sensitive adhesive sheet in which unevenness is formed on the exposed surfaces of a support and a covering material, so that the slippage between the sheets is good and it can be easily taken out from the packaging material. Patent Document 4 describes that two sheets are sealed in a storage container in a state of being overlapped with a flexible interposing material, and each sheet can be easily separated from the interposing material. ing. Patent Document 5 is included in the pressure-sensitive adhesive layer by folding the poultice along the folded portion formed by pressing the pressure-sensitive adhesive layer so that the plastic film covering the surface of the pressure-sensitive adhesive layer is on the outside. Disclose the volatilization of moisture and medicinal ingredients. Patent Document 6 discloses that a cloth piece and a film as a laminate are protruded from one side of the cloth piece, folded in two, and sealed in a sealed bag formed by welding the three film end portions protruding from the cloth piece. Disclosing enclosing a piece of fabric is disclosed. However, none of the materials described in the above-mentioned documents is satisfactory as a sheet-like patch because of its complicated structure or insufficient usability and convenience.

Japanese Utility Model Publication No. 52-1877 Japanese Utility Model Publication No. 62-191834 JP-A-7-126156 JP 2003-637 A Japanese Patent Laid-Open No. 10-95728 Japanese Utility Model Publication No. 48-94190

  Accordingly, an object of the present invention is to provide a sheet-like patch that does not cause unpleasant stickiness, maintains a favorable feeling of use, and can be easily taken out from a packaging material.

  The present inventors have found that the above-mentioned problems can be solved by subjecting the surface of the release film that is not in contact with the pressure-sensitive adhesive layer to a silicone treatment, while conducting extensive research to solve the above problems. As a result of further research, the present invention has been completed.

  That is, according to the present invention, in the sheet-like patch in which an adhesive layer is provided on one side of the support and the release film is further coated thereon, only the side of the release film that does not contact the adhesive layer is treated with silicone. The present invention relates to a sheet-like patch.

Moreover, this invention relates to the said sheet-like patch with which the side which contact | connects the adhesive layer of a release film is corona-treated.
Moreover, this invention relates to the said sheet-like patch whose adhesive layer consists of aqueous adhesives.
The present invention further relates to the sheet-like patch, wherein the aqueous pressure-sensitive adhesive is a hybrid gel containing a hydrogel and an oil gel.

The present invention also relates to the sheet-like patch, wherein the release film has a cut.
The present invention further relates to the sheet-like patch that is folded at least in two from the cut portion and hermetically packaged in a packaging material.
Moreover, this invention relates to the said sheet-like patch whose cut | interruption part is a secant or a perforation.

The present invention also includes the following steps:
(A) a step of spreading the pressure-sensitive adhesive composition on the non-silicone-treated side of the release film having one side treated with silicone, and further laminating a support thereon; and (b) (a A step of filling the packaging material with the sheet obtained in step 2) with the film on the inside and the support on the outside.
The present invention relates to a method for producing a sheet-like patch comprising
The present invention further relates to the above method, further comprising the step of making a cut in the film at a site serving as a reference for the fold before the step (b).

  According to the present invention, a sheet-like patch excellent in usability and handling property is provided without causing unpleasant stickiness due to bleeding due to phase separation or emulsion breakage of an oil component in an adhesive layer. Further, when the sheet-like patch provided by the present invention is used by being folded, the sheet-like patch is not only difficult to tear, but it is easy to separate the release films from each other when the sheet-like patch is taken out from the packaging material and developed. Is easy. In addition, the sheet-like patch of the present invention, which has been subjected to corona treatment on the side in contact with the adhesive layer, is easier to unfold because the release film and the adhesive layer are not easily peeled off, and is also separated to facilitate folding. Even in the case where the mold film has a cut, since the component bleed from the gel does not ooze out from the cut, it is excellent in usability and hygiene.

  The sheet-like patch of the present invention has a structure in which an adhesive layer is provided on one side of a support and a release film is further coated thereon, and the side that does not contact the adhesive layer of the release film is treated with silicone. It is characterized by.

  Usually, the silicone treatment facilitates the release of the release film from the adhesive layer, so the surface of the release film that contacts the adhesive layer is coated with a polysiloxane compound with low surface tension to release the adhesive layer. However, the present invention is characterized in that a part or the entire surface of the opposite side (the side not in contact with the adhesive layer of the release film) is subjected to silicone treatment. The side of the release film that is not in contact with the adhesive layer is treated with silicone, so that the oily component separated from the adhesive layer is less likely to “wet” the silicone surface (back surface of the release film). The progress of leaching between films is suppressed, and bleeding is unlikely to occur. Moreover, when sealing to a packaging material, the inner side of a packaging material and a release film may adhere | attach and it may become difficult to take out, but this can be prevented. Furthermore, even if the release film is folded inside and sealed inside the packaging material, it is easy to peel off the release films, so that the patch can be easily developed. It becomes difficult to peel off accidentally from the layer.

  The silicone treatment is not particularly limited as long as it is a commonly performed method. For example, after a silicone resin (release agent) is dissolved in a solvent or the like, it is applied to a film as a substrate using a coater or a gravure plate. It is applied by a method of removing the solvent by heating, a method of heat curing or UV curing, or a method of kneading with a resin of the base film and thermoplastic molding.

  The release film may be subjected to silicone treatment on the side in contact with the adhesive layer, as is usually used, but the surface on the side in contact with the adhesive layer is preferably treated so that it is not slippery, more preferably. Is processed so as to enhance the adhesion to the adhesive layer. Preferably, a corona treatment is performed on the entire surface or a part of the side in contact with the adhesive layer. By applying corona treatment, physical affinity (increased contact area) and chemical affinity (bonding by the generation of polar functional groups) are enhanced for gels that contain a large amount of oil components, improving gel adhesion. There is an effect of making it. By improving the adhesiveness between the release film and the gel, it is possible to prevent the release film from separating from the adhesive layer when the sheet-like patch is taken out from the packaging material. In particular, when a sheet-like patch is folded and sealed in a packaging material, the release film is easily peeled off from the adhesive layer due to adhesion between the release films, but the side of the release film that contacts the adhesive layer is corona-treated. This can prevent this.

  The corona treatment is not particularly limited as long as it is a commonly performed method, and a corona discharge is caused by applying a high-frequency / high-voltage output supplied by a high-frequency power source between the discharge electrode and the treatment roll. It is given by allowing the film to pass through. The affinity for the gel on the side in contact with the adhesive layer may be increased by other means usually used, for example, flame treatment.

The pressure-sensitive adhesive layer of the sheet-like patch of the present invention is not particularly limited as long as it is a pressure-sensitive adhesive usually used for sheet-like patches. For example, oil-based pressure-sensitive adhesives such as rubber-based pressure-sensitive adhesives, acrylic pressure-sensitive adhesives, and silicone-based pressure-sensitive adhesives. Alternatively, an aqueous adhesive can be used.
Moreover, the oil-based adhesive may be a base containing water, and when the adhesive layer contains water, the patch of the present invention can exert its effect particularly preferably.
The aqueous pressure-sensitive adhesive is preferably composed of a hydrogel obtained by gelling a water-soluble polymer such as a partially neutralized polyacrylic acid with water as a medium, and further comprises a hybrid gel obtained by mixing a hydrogel and an oil gel. preferable.

  The hybrid gel is a gel obtained by mixing a hydrogel mainly composed of water, a water-soluble polymer and a water-soluble component, and an oil gel mainly composed of an oil component such as a lipid component and a fat-soluble component. That is, it is a gel-like substance in which a hydrogel and an oil gel are mixed and a network is formed by cross-linking the hydrogel three-dimensionally to enclose the oil gel. In the sheet-like patch of the present invention, the mass ratio of the hydrogel and the oil gel in the hybrid gel is not particularly limited, but is preferably 70:30 to 99: 1, more preferably 80:20 to, from the viewpoint of the moisturizing effect. 95: 5, particularly preferably 85:15 to 95: 5. In the mass ratio of hydrogel and oil gel, if the ratio of oil gel is too large, the skin surface coating action by the oily component will be excessive, so water supply from the sheet-like patch to the skin will be obstructed and the desired moisturizing effect will be obtained. If the ratio of oil gel is too small, the skin will be replenished with moisture. However, the oily component will have insufficient skin surface coating, so moisture will be removed from the skin after the sheet-like patch has been peeled off. Tends to evaporate and the moisturizing effect tends not to last.

  The hydrogel is not particularly limited as long as it is a gel using water as a medium. For example, a part of the hydrogel is insolubilized by crosslinking a water-soluble polymer and swollen with water, glycols and / or polyhydric alcohols. The gel etc. which were made to use are used suitably. A polyvalent metal compound can be used for the formation of the crosslinking, and a sequestering agent and a pH adjusting agent may be added as necessary. Moreover, it is good also as a gel which introduce | transduced the hydrophobic group or the crystal structure, etc. into the water-soluble polymer instead of introduce | transducing the said bridge | crosslinking.

  The water-soluble polymer blended in the hydrogel includes polyacrylic acid partially neutralized product, polyacrylic acid complete neutralized product, polyacrylic acid, carboxyvinyl polymer, carboxymethylcellulose, sodium carboxymethylcellulose, gelatin, casein, pullulan. , Agar, dextran, sodium alginate, soluble starch, carboxy starch, dextrin, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, polyvinyl alcohol, polyethylene oxide, polyacrylamide, polyvinyl pyrrolidone, polyvinyl ether-maleic anhydride copolymer, methoxyethylene-maleic anhydride Examples include acid copolymers, isobutylene-maleic anhydride copolymers, and polyethyleneimine. Among them, a preferable water-soluble polymer is a partially neutralized polyacrylic acid, particularly a sodium salt having a neutralization degree of 20 to 80% and an average polymerization degree of 1,000 to 100,000. Used for.

  The blending amount of the water-soluble polymer is preferably 3 to 10% by mass, more preferably, based on the entire adhesive layer of the sheet-like patch from the viewpoints of adhesiveness, cohesiveness, shape retention, water absorption ability, and the like. It is 4-8 mass%. If the amount of the water-soluble polymer is too small, the adhesiveness, cohesiveness, shape retention and water-absorbing ability of the gel will decrease, the gel will become non-uniform, the back of the substrate (seepage) and tongue out. (Extruding of gel), reduction of gel spreadability, feeling of use, reduction of transdermal absorbability of active ingredient, and tendency to bleed oily component. Reduces adhesiveness, cohesiveness, and shape retention of the gel, makes the gel non-uniform, reduces spreadability, decreases the feeling of use, decreases the moisturizing effect, decreases the transdermal absorbability of the active ingredient, and bleeds the oily component It tends to occur easily.

  On the other hand, the oil gel is not particularly limited as long as it is a gel using a liquid oil component as a medium. For example, the oil gel is formed by mixing sucrose fatty acid ester, organic bentonite, dextrin fatty acid ester or the like with the liquid oil component as a gelling agent. A suitable gel is preferably used.

  Examples of the liquid oil component blended in the oil gel include polyhydric alcohol fatty acid esters. Examples of the polyhydric alcohol fatty acid ester suitable for the oil gel used in the present invention include diglyceryl triisostearate, propylene glycol dicaprate, pentaerythritol tetra-2-ethylhexanoate, propylene glycol monocaprylate, propylene glycol dicaprylate, tri-2 -Trimethylolpropane ethylhexanoate, trimethylolpropane triisostearate, glyceryl tri-2-ethylhexanoate, glyceryl tri (capryl-caprate), 2-butyl-2-ethyl-1,3-propane 2-ethylhexanoate Diols can be used, and one or two or more selected from this group can be used in combination. Among these, particularly preferred polyhydric alcohol fatty acid esters include glyceryl tri-2-ethylhexanoate.

  The glyceryl tri-2-ethylhexanoate preferably has a saponification value (according to the saponification value test method of “Glyceryl Tri-2-ethylhexanoate” according to the formulation standard for cosmetic varieties (makeup regulations)) of 340 to 370, The specific gravity (20 ° C.) is preferably 0.949 to 0.959.

  The polyhydric alcohol fatty acid ester is preferably 1 to 20% by mass, more preferably 5 to 15% by mass, based on the entire adhesive layer of the sheet-like patch, from the viewpoint of gel spreading and tackiness and prevention of bleeding. %. If the amount of polyhydric alcohol fatty acid ester is too small, the spreadability of the gel, the feeling of use as a patch, the moisturizing effect, the skin safety and the percutaneous absorption of the active ingredient tend to decrease. On the other hand, if the blending amount is too large, the adhesiveness, cohesiveness, shape retention and water absorption ability of the gel will be reduced, the gel will become non-uniform, and the back of the support during the manufacturing process (seepage) Prone to tongue sticking (extruding gel), bleeding of oily components, reduced gel spreading, reduced use feeling and moisturizing effect as a patch, reduced skin safety and transdermal absorbability of active ingredients Become.

  Examples of the gelling agent for the oil gel include sucrose fatty acid ester, organic bentonite, and dextrin fatty acid ester. Among these, dextrin fatty acid ester is particularly preferable. Furthermore, among dextrin fatty acid esters, those having a gel strength of 10 to 300 g are preferred, and those having a gel strength of 30 to 250 g are more preferred. In this specification, the gel strength of dextrin fatty acid ester refers to a value obtained by the following test method.

<Gel strength test method>
Weigh accurately 5 g of dextrin fatty acid ester in a flat bottom container with an inner diameter of 45 mm, add 45 g of liquid paraffin (# 70), disperse, and dissolve by heating to 90 ° C. while gently stirring. Immediately thereafter, the mixture is allowed to stand for 24 hours in a thermostatic bath at 30 ° C. to form a gel. This gel is quickly set on a rheometer (manufactured by Sun Science, SUN RHEO METER CR-500DX) so as not to cause a temperature change, and the gel strength is measured under the following conditions. The initial peak, that is, the yield value (g) is defined as the gel strength.

The measurement conditions are
Temperature: 30 ° C
Adapter: φ20mm, 2mm thick disk Mounting speed: 60mm / min
It is.

  Preferred examples of the dextrin fatty acid ester of the gelling agent include palmitic dextrin, palmitic acid / octanoic acid dextrin, and myristic dextrin, and one or two or more selected from these groups can be used in combination. However, it is particularly preferred to use dextrin palmitate alone.

  The gelling agent dextrin palmitate preferably has an acid value (according to the acid value test method of “dextrin palmitate”, “Additives for Pharmaceutical Additives”), preferably 38 or less, more preferably 10 or less. . In addition, the melting point of dextrin palmitate (according to the drug supplement “dextrin palmitate” confirmation test (3)) is preferably 50 to 63 ° C. This is because if an acid value, melting point, or gel strength outside the above range of dextrin palmitate is used, bleeding of oily components may occur.

  The blending amount of the dextrin fatty acid ester is preferably 0.05 to 3% by mass, more preferably 0.1 to 2%, based on the entire adhesive layer of the sheet-like patch, from the viewpoint of adhesiveness and moisturizing effect. % By mass. If the amount of the dextrin fatty acid ester is too large, the viscosity of the gel will increase and become stiff, leading to a decrease in adhesiveness, cohesiveness, and water absorption capacity. Further, if the blending amount is too small, the oily component cannot be sufficiently retained in the gel, and the oily component bleeds to cause the skin to become sticky and the feeling of use tends to be unfavorable.

  The hybrid gel may further contain glycols and / or polyhydric alcohols, one of these may be used alone, or two or more may be used in combination. Glycols are used as dispersing / dissolving agents or plasticizers for water-soluble polymers, moisturizing components, crosslinking agents, skin-beautifying components, preservatives, etc., and can promote water release and volatility.

  In addition to the above components, the adhesive layer of the sheet-like patch of the present invention or the hybrid gel is a known crosslinking agent, preservative, active ingredient, skin beautifying agent, moisturizing agent, antioxidant, depending on the use of the patch. Adequate amounts of tackifiers, solubilizers, dyes / pigments, fragrances, surfactants, ultraviolet absorbers, fillers, cooling sensation agents, warming sensation agents, pH adjusting agents, and the like can be appropriately blended. Suitable examples of each component are described, for example, in JP-A-2006-206540, the entirety of which is incorporated herein by reference.

  The hybrid gel contained in the adhesive layer of the sheet-like patch of the present invention is, for example, by first dissolving an essential component of an oil gel to form an oil gel, and separately mixing the hydrogel prepared separately and the oil gel, Can be crosslinked to produce a hybrid gel.

When the adhesive layer is a hybrid gel of hydrogel and oil gel, the sheet-like patch of the present invention can exhibit the following effects in combination with the medicinal merits unique to the sheet-like patch.
1. Promotes percutaneous absorption of beautifying skin ingredients and drugs due to ODT effect, and promotes secretion of waste products from the skin.
2. Release of water-soluble components and drugs and hydration with hydrogel.
3. Releases fat-soluble ingredients and drugs with oil gel, suppresses moisture transpiration from the skin, and protects the skin from the outside.

The sheet-like patch of the present invention comprises a support and a release film in addition to the adhesive layer.
The material of the support is not particularly limited, but polyethylene, polypropylene, ethylene-vinyl acetate copolymer, vinyl chloride, polyurethane, polyethylene terephthalate, polyester such as polybutylene terephthalate, polyamide such as nylon, rayon, pulp , A cellulose or a derivative thereof such as cotton, or a combination of one or more selected from materials such as polyacrylonitrile, and a woven fabric or a non-woven fabric made by entanglement, heat fusion, pressure bonding or binder bonding preferable. In particular, a polyester nonwoven fabric is preferably used. Preferably this case the basis weight of the support is 20 to 200 g / ^{m 2,} more preferably 40 to 120 g / ^{m 2,} more preferably from 80 to 120 / ^{m 2.} If the basis weight of the support is too low, there is a tendency to cause shape breakage such as tearing, appearance due to leaching when applying the adhesive layer, poor feeling of use and shape retention, and difficulty in sticking when sticking, This tendency is particularly remarkable at less than 20 g / m ² . Further, if the basis weight of the support is too high, there is a tendency to cause a decrease in usability due to poor stretchability or poor flexibility of the support, turning over at the time of application, and further cost increase as a material, exceeding 200 g / m ² . This is especially true.

Furthermore, the thickness of the support is preferably 0.1 to 1.5 mm, more preferably 0.5 to 1.0 mm, when measured with a pressure of 0.98 N per 5 cm ^{2 of} contact area. If the support is too thin, there is a tendency to cause shape failure such as tearing, appearance failure due to leaching when the adhesive layer is applied, molding defects, and difficulty in sticking at the time of application, especially at less than 0.1 mm. The trend is remarkable. In addition, if the support is too thick, there is a tendency to reduce the usability due to poor stretchability or poor flexibility of the support, turn over when applying the patch, and further increase the cost as a material, exceeding 1.5 mm This is especially true.

  Furthermore, the color of the support is not particularly limited, but it has a significant effect on the product image of the patch, leading to improved aesthetics and a feeling of use when applied to the human body, so white, skin color, yellow, red, orange Green, blue, pink, light blue, brown, and the like are preferable examples, and those with light and shade adjusted as needed are more preferable. Processing such as printing and embossing is also possible as appropriate.

In order to protect the surface of the adhesive layer, the release film covers the entire surface of the adhesive layer until use.
The material of the release film is not particularly limited, but polyethylene, polypropylene, ethylene-vinyl acetate copolymer, ethylene-vinyl alcohol copolymer, vinyl chloride, polyurethane, polyethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate. Polyester such as nylon, polyamide such as nylon, polyacrylonitrile, cellulose or derivatives thereof, or a film formed by combining one or more selected from materials such as metal foil such as aluminum is preferable. In particular, polyethylene terephthalate is preferably used.

  The thickness of a release film becomes like this. Preferably it is 20-150 micrometers, More preferably, it is 40-120 micrometers, More preferably, it is 50-100 micrometers. If the film is too thin, shape breakage such as tearing due to strength reduction, manufacturing trouble of the patch, and difficulty in sticking at the time of sticking are caused. In addition, if the film is too thick, the cutting suitability of the film in the manufacture of the patch is poor, the film is turned over at the time of application, and the cost as a raw material is increased.

  In addition, the release film is subjected to processing such as secanting, perforation, and printing for the purpose of improving peelability or stickability, and embossing is performed for the purpose of improving the appearance and preventing the film from shifting. It is possible as appropriate. By providing a scored line or perforated cut, it is preferable in that it can be folded thinly with reference to the cut when packaging into a packaging material.

  Until the time of use, the sheet-like patch composed of the above-described composition is formed by depositing, for example, polyethylene (PE), polypropylene (PP), polyethylene terephthalate (PET), nylon, paper and aluminum foil composite film, or aluminum. Although it is stored in a packaging bag such as a film, it is enclosed in the packaging bag by folding at least in half from the axis of symmetry of the corresponding body mainly from an economical point of view. In particular, large-sized poultices and face masks are often folded and packaged from the viewpoint of distribution, sales, and packaging aesthetics. However, it is possible to prevent the tear from being broken and broken by at least folding in half. Furthermore, in the case of a face patch or the like, an opening may be provided in a portion corresponding to the eye or mouth in the case of a face mask, etc., and in the conventional one, when the patch is taken out from the bag, the sheet is torn off from the opening. However, this can be prevented by folding it at least in half.

  When folding, from the viewpoint of aesthetics and handleability, the support side should be folded so that the release films are in contact with each other from the outside, that is, from the cut (perforation or perforation) portion of the release film. Is preferred. Even if the release film is folded so that the release film is on the inside, the sheet-like patch of the present invention is difficult to get wet because the release film is treated with silicone, and the oily component bleed from the gel breaks the release film. Since it does not ooze out from the part (or leaching is remarkably suppressed), stickiness hardly occurs, it is excellent in usability and hygienic. Further, when the support is folded outside, the patch can be smoothly taken out from the bag.

In addition, the size of the sheet-like patch is not limited, but large-sized patches and face masks are often folded and packaged, and the sheet-like patch of the present invention is particularly useful in such cases. is there. The size of the sheet-like patch of the present invention is typically 20 to 900 cm ² , preferably 20 to 300 cm ² .

Hereinafter, the sheet-like patch of the present invention will be described in more detail with reference to Examples and Test Examples, but these do not limit the present invention.
<Example 1>
After heating and dissolving 10% by mass of glyceryl tri-2-ethylhexanoate, 1% by mass of dextrin palmitate, and 0.1% by mass of a beautifying skin component (vitamin C derivative), the temperature was returned to room temperature to form an oil gel.
Separately, purified water 52.05% by mass, polyacrylic acid partially neutralized product 6.5% by mass, synthetic aluminum silicate 4% by mass, cross-linking agent 0.4% by mass, sequestering agent 0.35% by mass, antiseptic 0.2% by mass of the agent, 0.1% by mass of the pH adjusting agent, 10% by mass of concentrated glycerin, 15% by mass of polyethylene glycol, and 0.3% by mass of the skin beautifying component (plant extract) are uniformly mixed. Prepared.
The above hydrogel and oil gel were uniformly mixed to prepare a hybrid gel.

Next, the hybrid gel is applied to a thickness of about 860 g / m ² on the corona treatment side of a polyethylene terephthalate release film having a corona treatment on one side and a light-peeling silicone treatment on the other side. It was spread and a support was laminated thereon. The obtained sheet is cut into a face shape, and at the same time, a cut is made in the release film at the longitudinal center of the face, and the sheet is folded in half so that the release films are in contact with each other, and filled into an aluminum laminate packaging bag. Thus, a sheet-like patch of the present invention was obtained.

<Example 2>
A hybrid gel was prepared in the same manner as in Example 1.
Next, on the corona treatment side of the release film made of polyethylene terephthalate, which has been subjected to corona treatment on one side and heavy peelable silicone treatment on the other side, the above hybrid gel is applied at a thickness of about 860 g / m ^2. It was spread and a support was laminated thereon. The obtained sheet is cut into a face shape, and at the same time, a cut is made in the release film at the longitudinal center of the face, and the sheet is folded in half so that the release films are in contact with each other, and filled into an aluminum laminate packaging bag. Thus, a sheet-like patch of the present invention was obtained.

<Comparative Example 1>
A hybrid gel was prepared in the same manner as in Example 1.
Next, the hybrid gel is spread at a thickness of about 860 g / m ² on the corona treatment side of the polyethylene terephthalate release film having only one corona treatment on one side, and a support is laminated thereon. did. The obtained sheet is cut into a face shape, and at the same time, a cut is made in the release film at the longitudinal center of the face, and the sheet is folded in half so that the release films are in contact with each other, and filled into an aluminum laminate packaging bag. Thus, a sheet-like patch of the present invention was obtained.

<Test example>
For the packaged patches of Example 1-2 and Comparative Example 1, after preparation (initial) and at a temperature of 25 ° C., a relative humidity of 60%, a temperature of 40 ° C., a relative humidity of 75%, a temperature of 50 ° C., a relative humidity of 75%, Store for 1 to 3 months in an atmosphere of 60% temperature and 75% relative humidity, and then observe and evaluate the properties of the outer surface of the release film of the patch (the surface not in contact with the adhesive layer) according to the following criteria. did. The results are shown in Table 1.

  As shown in Table 1, the results of the evaluation showed that the patch of the comparative example was already clearly unpleasant after 1 month of storage, whereas the patches of Examples 1 and 2 were hot. After 6 months of storage, no unpleasant stickiness was observed.

  As described above, the sheet-like patch of the present invention suppresses bleeding of oily components, has a good feeling of use, is easy to develop at the time of use, and is excellent in storage stability and handleability. Application to pharmaceuticals and quasi drugs is expected.

Claims (12)

  In the sheet-like patch in which an adhesive layer is provided on one side of the support and the release film is further coated thereon, only the side of the release film that does not contact the adhesive layer is treated with silicone. Agent. The sheet-like patch according to claim 1, wherein the adhesive layer contains an aqueous adhesive. The sheet-like patch according to claim 1 or 2, wherein the adhesive layer contains an aqueous adhesive, and the aqueous adhesive is a hybrid gel containing a hydrogel and an oil component . The sheet-like patch according to any one of claims 1 to 3, wherein the sheet-like patch is folded at least in half with the release film inside. The sheet-like patch according to any one of claims 1 to 4, wherein the silicone treatment is a light-peeling silicone treatment. The sheet-like patch according to any one of claims 1 to 5 , wherein the side of the release film that contacts the adhesive layer is corona-treated. The sheet-like patch according to any one of claims 1 to 6 , wherein the release film has a break. The sheet-like patch according to any one of claims 1 to 7 , which is folded at least in two from the cut portion and hermetically packaged in a packaging material. The sheet-like patch according to any one of claims 1 to 8 , wherein the release film has a cut, and the cut is a secant or a perforation. The following steps:
(A) Spreading the pressure-sensitive adhesive composition on the non-siliconized side of the release film having one side treated with silicone, and further laminating a support thereon; and (b) A step of filling the sheet obtained in (a) with at least two folds with the film on the inside and filling the packaging material with the support on the outside;
A method for producing a sheet-like patch comprising: The method according to claim 10, wherein the pressure-sensitive adhesive composition contains an aqueous pressure-sensitive adhesive, and the aqueous pressure-sensitive adhesive contains a hybrid gel containing a hydrogel and an oily component. The method according to claim 10 or 11 , further comprising a step of making a cut in the film at a site serving as a reference for the fold before the step (b).