CN103316078B - Sleep aiding and cooling patch and preparation method thereof - Google Patents
Sleep aiding and cooling patch and preparation method thereof Download PDFInfo
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- CN103316078B CN103316078B CN201310247118.XA CN201310247118A CN103316078B CN 103316078 B CN103316078 B CN 103316078B CN 201310247118 A CN201310247118 A CN 201310247118A CN 103316078 B CN103316078 B CN 103316078B
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Abstract
The invention discloses a sleep aiding and cooling patch and a preparation method thereof. The patch consists of a backing layer, a gel layer and a release film; the gel layer consists of 5 to 15 parts of macromolecular substance, 0.2 to 2 parts of cross-linking agent and crosslink conditioning agent, 10 to 30 parts of humectant, 0.01 to 0.5 part of asbolin, 0.01 to 0.05 part of lavender essential oil, 0.01 to 0.05 part of menthol, 0.2 to 1 part of alcohol and 55 to 85 parts of purified water. The patch disclosed by the invention adopts a transdermal drug delivery system (TDDS) technology, and the nerves calming and sleep aiding effects of the asbolin and the lavender essential oil and the cooling and refreshing effects of the menthol and the alcohol are integrated to prepare a hydrogel patch. The sleep aiding and cooling patch disclosed by the invention is convenient to use, can be adhered repeatedly, does not hurt the skin, does not have residue, toxicity or harm, has fragrant and pleasant smell and lasting sleep aiding and cooling effects, and is particularly suitable for cooling in fever and summer.
Description
Technical field
The invention belongs to medical art, relate to a kind of dormancy temperature-reducing paste that relaxes.
Technical background
Temperature-reducing paste is also referred to as defervescence plaster used, is affixed on human skin, utilizes the TDDS technology of international popular to make moisture and drug transdermal enter skin, and the physical change of then being absorbed heat by water vapor is reached falls hypothermic effect.It belongs to Physical temperature-lowering articles for use, is widely used in fever of children fever and summer-heat removing.Temperature-reducing paste composition in the market mainly based on polymer substance and Mentholum, Borneolum Syntheticum, only has simple cooling effect, without dormancy effect of relaxing.No matter and fever is generated heat or summer-heat is unbearable, all easily make people irritated, headache, whole body is uncomfortable, also difficulty of falling asleep.Now be more suitable for using the temperature-reducing paste with easypro dormancy effect.
Pinaster stump wood temples part rotten rear remaining conjunction fat portion collection, the dry distilling gained liquid of asbolin system over-logged forest area, have the effect of tranquillizing and allaying excitement.The inhalant that asbolin is made belongs to nonprescription drugs, and the adjuvant drug as insomnia uses.
Herba Lysimachiae foenum-graeci quintessence oil is refined by lavandula angustifolia and forms, and is usually used in controlling oily skin protection and fatigue alleviating, has good effect to relieving mental strain and helping sleep.In addition the quiet and beautiful fragrance of lavandula angustifolia is also extensively liked, therefore Herba Lysimachiae foenum-graeci quintessence oil is broadly used as essence and flavoring agent.
Mentholum system is by the white crystal extracted in the leaf of Herba Menthae and stem, and the refrigerant sense of its clearing away heat and removing summer effect and uniqueness thereof makes it be widely used in each fields such as menthocamphorate processed, analgesic, toothpaste, confection, beverage.
Asbolin, Herba Lysimachiae foenum-graeci quintessence oil and Mentholum all derive from natural plant extracts, and safe without toxic side effect is combined together, and have unique pleasant delicate fragrance, add in gel and slowly discharge, lasting fragrance, relieving mental strain and helping sleep, be more conducive to the performance of cooling effect.
Summary of the invention
The object of the present invention is to provide a kind of have to relax sleep and patch and preparation method thereof of cooling effect.
The present invention is achieved by the following technical solutions:
A kind of cooling patch and preparation method thereof of sleeping that relaxes, it is characterized in that: be made up of backing layer, gel layer and mould release membrance, gel layer is made up of the component of following percentage by weight: polymer substance 5-15 part, cross-linking agent and cross-linking regulator 0.2-2 part, wetting agent 10-30 part, asbolin 0.01-0.05 part, Herba Lysimachiae foenum-graeci quintessence oil 0.01-0.05 part, Mentholum 0.01-0.05 part, ethanol 0.2-1 part, purified water 55-85 part.
Described polymer substance is the mixture of one or more in carbomer, carboxymethyl cellulose, hypromellose, sodium polyacrylate, gelatin, polyvinyl alcohol, polyvinylpyrrolidone.
Described cross-linking agent is the mixture of one or more in aluminum, aluminum chloride, aluminium sesquioxide, dihydroxyaluminum aminoacetate, and cross-linking regulator is the mixture of one or more in citric acid, tartaric acid, glacial acetic acid, citric acid, formic acid.The ratio 1: 0.5 ~ 5 of cross-linking agent and cross-linking regulator.
Described wetting agent is the mixture of one or more in glycerol, propylene glycol, Polyethylene Glycol, vitamin E.
Described backing layer is non-woven fabrics or stretch fabric.
Described mould release membrance is PE film or PET film.
A kind of preparation method of easypro cooling patch of sleeping is as follows:
(1) polymer substance is got and cross-linking regulator adds purified water, stirring and dissolving;
(2) cross-linking agent and wetting agent mixing and stirring is got;
(3) by above-mentioned two solution mix and blends uniformly gel;
(4) get asbolin, Herba Lysimachiae foenum-graeci quintessence oil, Mentholum dissolve with ethanol, add in gel, stir;
(5) the above-mentioned gel prepared is applied on backing through coating machine, covers mould release membrance simultaneously;
(6) required size and shape is cut into, packaging.
Advantage of the present invention is: the invention provides a kind of hydrogel patch with relax dormancy and cooling double effects, easy to use, can repeatedly paste, do not hinder skin, noresidue, abnormal smells from the patient delicate fragrance is pleasant, nontoxic, easypro dormancy and cooling effect lastingly, are particularly useful for fever heating and cooling of relieving summer heat.
Detailed description of the invention
Below technical scheme of the present invention is described, so that those skilled in the art understand.
Mixture and the cross-linking regulator of getting one or more in polymer substance add purified water, stirring and dissolving; Get the mixture of one or more in cross-linking agent and wetting agent, stir; By these two kinds of solution mix and blends uniformly gel; Get asbolin, Herba Lysimachiae foenum-graeci quintessence oil, Mentholum dissolve with ethanol, add in gel, stir; The above-mentioned gel prepared is applied on backing through coating machine, covers mould release membrance simultaneously; Cut into required size and shape, packaging.
The different ratio of gel component is shown in following embodiment:
Embodiment 1
Get mass fraction carbomer 5 parts, polyvinyl alcohol 5 parts, glycerol 20 parts, aluminium sesquioxide 0.1 part, 0.1 part, tartaric acid, asbolin 0.02 part, Herba Lysimachiae foenum-graeci quintessence oil 0.02 part, Mentholum 0.01 part, ethanol 0.5 part, purified water 70 parts, make cooling patch.
Embodiment 2
Get mass fraction sodium polyacrylate 10 parts, dihydroxyaluminum aminoacetate 0.5 part, citric acid 1 part, propylene glycol 15 parts, vitamin E2 part, asbolin 0.02 part, Herba Lysimachiae foenum-graeci quintessence oil 0.02 part, Mentholum 0.01 part, ethanol 0.5 part, purified water 72 parts, make cooling patch.
Embodiment 3
Get mass fraction carboxymethyl cellulose 10 parts, aluminium sesquioxide 0.2 part, 0.1 part, formic acid, 2 parts, gelatin, polyvinylpyrrolidone 3 parts, glycerol 30 parts, asbolin 0.02 part, Herba Lysimachiae foenum-graeci quintessence oil 0.02 part, Mentholum 0.01 part, ethanol 0.5 part, purified water 55 parts, make cooling patch.
Embodiment 4
Get mass fraction sodium polyacrylate 5 parts, aluminum chloride 0.1 part, citric acid 0.1 part, hypromellose 3 parts, propylene glycol 15 parts, vitamin E2 part, asbolin 0.02 part, Herba Lysimachiae foenum-graeci quintessence oil 0.02 part, Mentholum 0.01 part, ethanol 0.5 part, purified water 75 parts, make cooling patch.
Embodiment 5
Get mass fraction sodium polyacrylate 10 parts, aluminium sesquioxide 0.1 part, 0.1 part, tartaric acid, propylene glycol 15 parts, asbolin 0.05 part, Herba Lysimachiae foenum-graeci quintessence oil 0.01 part, Mentholum 0.01 part, ethanol 0.5 part, purified water 75 parts, make cooling patch.
Embodiment 6
Get mass fraction sodium polyacrylate 10 parts, aluminium sesquioxide 0.1 part, 0.1 part, tartaric acid, propylene glycol 15 parts, vitamin E2 part, asbolin 0.01 part, Herba Lysimachiae foenum-graeci quintessence oil 0.05 part, Mentholum 0.01 part, ethanol 0.5 part, purified water 73 parts, make cooling patch.
Embodiment 7
Get mass fraction sodium polyacrylate 10 parts, aluminium sesquioxide 0.1 part, 0.1 part, tartaric acid, propylene glycol 15 parts, vitamin E2 part, asbolin 0.01 part, Herba Lysimachiae foenum-graeci quintessence oil 0.01 part, Mentholum 0.02 part, ethanol 0.3 part, purified water 73 parts, make cooling patch.
Above-mentioned invention to be exemplarily described; obvious specific implementation of the present invention is not subject to the restrictions described above; as long as have employed this insubstantial that method of the present invention is conceived and technical scheme is carried out to improve; or the design of invention and technical scheme directly applied to other occasions, all within protection scope of the present invention without to improve.
Claims (7)
1. the cooling patch of sleeping that relaxes, it is characterized in that: be made up of backing layer, gel layer and mould release membrance, gel layer is made up of the component of following mass percent: polymer substance 5-15 part, cross-linking agent and cross-linking regulator 0.2-2 part, wetting agent 10-30 part, asbolin 0.01-0.05 part, Herba Lysimachiae foenum-graeci quintessence oil 0.01-0.05 part, Mentholum 0.01-0.05 part, ethanol 0.2-1 part, purified water 55-85 part.
2. the easypro cooling patch of sleeping of one according to claim 1, is characterized in that: described polymer substance is the mixture of one or more in carbomer, carboxymethyl cellulose, hypromellose, sodium polyacrylate, gelatin, polyvinyl alcohol, polyvinylpyrrolidone.
3. the easypro cooling patch of sleeping of one according to claim 1, it is characterized in that: described cross-linking agent is the mixture of one or more in aluminum, aluminum chloride, aluminium sesquioxide, dihydroxyaluminum aminoacetate, cross-linking regulator is the ratio 1: 0.5 ~ 5 of the mixture of one or more in citric acid, tartaric acid, glacial acetic acid, citric acid, formic acid, cross-linking agent and cross-linking regulator.
4. the easypro cooling patch of sleeping of one according to claim 1, is characterized in that: described wetting agent is the mixture of one or more in glycerol, propylene glycol, Polyethylene Glycol, vitamin E.
5. the easypro cooling patch of sleeping of one according to claim 1, is characterized in that: described backing layer is non-woven fabrics or stretch fabric.
6. the easypro cooling patch of sleeping of one according to claim 1, is characterized in that: described mould release membrance is PE film or PET film.
7. the preparation method of a kind of easypro cooling patch of sleeping according to claims 1 to 6, is characterized in that: described preparation method is as follows:
(1) polymer substance is got and cross-linking regulator adds purified water, stirring and dissolving;
(2) cross-linking agent and wetting agent mixing and stirring is got;
(3) the two solution mix and blends made in above-mentioned (1), (2), make uniform gel;
(4) get asbolin, Herba Lysimachiae foenum-graeci quintessence oil, Mentholum dissolve with ethanol, add in gel, stir;
(5) the above-mentioned gel prepared is applied on backing through coating machine, covers mould release membrance simultaneously;
(6) required size and shape is cut into, packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310247118.XA CN103316078B (en) | 2013-06-18 | 2013-06-18 | Sleep aiding and cooling patch and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310247118.XA CN103316078B (en) | 2013-06-18 | 2013-06-18 | Sleep aiding and cooling patch and preparation method thereof |
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| Publication Number | Publication Date |
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| CN103316078A CN103316078A (en) | 2013-09-25 |
| CN103316078B true CN103316078B (en) | 2015-01-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310247118.XA Active CN103316078B (en) | 2013-06-18 | 2013-06-18 | Sleep aiding and cooling patch and preparation method thereof |
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| CN (1) | CN103316078B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105687446A (en) * | 2016-04-21 | 2016-06-22 | 吴美燕 | Preparation method of intelligent traditional Chinese medicine fever abatement paste |
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| CN103877168A (en) * | 2014-02-26 | 2014-06-25 | 高雄英 | Health-care fever cooling patch |
| EP2946775A1 (en) * | 2014-05-20 | 2015-11-25 | LTS LOHMANN Therapie-Systeme AG | Transdermal therapeutic system containing lavender oil |
| CN104337796A (en) * | 2014-10-12 | 2015-02-11 | 浙江欧洁科技股份有限公司 | Polymeric hydrogel fever cooling patch for children and preparation method thereof |
| CN104352483A (en) * | 2014-10-17 | 2015-02-18 | 南京斯瑞奇医疗用品有限公司 | Air conditioner paste with refrigeration function |
| CN104436206B (en) * | 2014-12-17 | 2018-09-21 | 广西德之然生物科技有限公司 | A kind of plant colloidal materials and preparation method thereof preparing defervescence plaster used use |
| CN104547023A (en) * | 2015-01-23 | 2015-04-29 | 广州九润生物科技有限公司 | Day and night fever-cooling patches |
| CN104706768A (en) * | 2015-03-12 | 2015-06-17 | 施敬东 | Patch capable of calming nerves and helping sleep and preparation method of patch |
| CN104688880A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Headache-relieving pad and preparation method thereof |
| CN104688813A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Nerve-soothing and eye-relaxing pad and preparation method thereof |
| CN105168118A (en) * | 2015-09-30 | 2015-12-23 | 安徽丰乐香料有限责任公司 | Preparation method of natural menthol or peppermint oil hydrogel |
| CN105878218A (en) * | 2016-04-21 | 2016-08-24 | 吴美燕 | Preparation method of intelligent children's fever cooling patch |
| CN105919981A (en) * | 2016-06-28 | 2016-09-07 | 江苏迪沃生物制品有限公司 | Defervescence patch and preparation process thereof |
| CN108066806A (en) * | 2016-11-10 | 2018-05-25 | 天津市赛远保健品有限公司 | A kind of novel environment friendly cold compress patch |
| CN106421540A (en) * | 2016-12-28 | 2017-02-22 | 四川默森药业有限公司 | Patch for soft tissue damage and preparation method of patch |
| CN106729415A (en) * | 2016-12-31 | 2017-05-31 | 唐山天恩科技有限公司 | Scar of dispelling gel rubber plaster and preparation method thereof |
| CN107115173A (en) * | 2017-06-13 | 2017-09-01 | 合肥旁耘科技有限公司 | One kind water suction cooling paster and preparation method thereof |
| CN111297906B (en) * | 2019-11-14 | 2023-06-09 | 青岛兔护士海洋生物科技有限公司 | Bear gall cooling patch and preparation method thereof |
| CN111012764A (en) * | 2019-12-24 | 2020-04-17 | 广州世和生物科技有限公司 | Testis cooling patch and preparation method thereof |
| CN111265479A (en) * | 2020-03-10 | 2020-06-12 | 中山市天图精细化工有限公司 | Cold aerosol patch and preparation method thereof |
| CN114917206A (en) * | 2022-05-06 | 2022-08-19 | 江苏益仁堂生物科技有限公司 | Medical cold compress patch and preparation method thereof |
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| CN1883450A (en) * | 2005-06-23 | 2006-12-27 | 广州市拜澳生物科技有限公司 | A hydrophilic gel plaster substrate |
| CN2843450Y (en) * | 2005-07-29 | 2006-12-06 | 徐庆聚 | A kind of pad pasting |
| CN2848220Y (en) * | 2005-11-29 | 2006-12-20 | 陈锦涛 | Fever downing refreshment plaster |
| CN101468094A (en) * | 2007-12-28 | 2009-07-01 | 天津市中宝制药有限公司 | Gel patch for resisting fatigue and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105687446A (en) * | 2016-04-21 | 2016-06-22 | 吴美燕 | Preparation method of intelligent traditional Chinese medicine fever abatement paste |
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| CN103316078A (en) | 2013-09-25 |
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Inventor after: Tao Chunlei Inventor after: Zhang Sheng Inventor after: Hong Lian Inventor before: Tao Chunlei |
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Free format text: CORRECT: INVENTOR; FROM: TAO CHUNLEI TO: TAO CHUNLEI ZHANG SHENG HONG LIAN |
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Address after: Tianda high tech Zone 230000 Hefei Road, Anhui province No. 71 Huayi Science Park building D2 Room 601 Patentee after: Anhui Wanbang Pharmaceutical Technology Co.,Ltd. Address before: Tianda high tech Zone 230000 Hefei Road, Anhui province No. 71 Huayi Science Park building D2 Room 601 Patentee before: ANHUI WANBANG MEDICAL TECHNOLOGY Co.,Ltd. |