CN106421540A - Patch for soft tissue damage and preparation method of patch - Google Patents
Patch for soft tissue damage and preparation method of patch Download PDFInfo
- Publication number
- CN106421540A CN106421540A CN201611232586.XA CN201611232586A CN106421540A CN 106421540 A CN106421540 A CN 106421540A CN 201611232586 A CN201611232586 A CN 201611232586A CN 106421540 A CN106421540 A CN 106421540A
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- China
- Prior art keywords
- patch
- oil
- soft tissue
- tissue injury
- cross
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Abstract
The invention discloses a patch for soft tissue damage and a preparation method of the patch. The patch comprises a nonwoven cloth backing layer, a gel layer, a release paper covering layer and the like. The gel layer comprises menthol, ethanol, a gel base material, a pressure-sensitive adhesive and the like, and has the defervescence and cold-compressing effect. The patch can be used for cold compressing and defervescence of children and adults after being applied to foreheads, can be used for cooling and cold compressing of soft tissue damage caused by scapulohumeral periarthritis, cervical spondylosis, lumbar muscle degeneration, traumatic injuries and the like after being applied to body parts such as necks, shoulders, waists and legs, and has a certain auxiliary treatment effect on the scapulohumeral periarthritis, the cervical spondylosis, the lumbar muscle degeneration and the traumatic injuries. The patch has the advantages that the gel base material is made from a medical high-molecular material, and accordingly, irritation to skin can be reduced.
Description
Technical field
The present invention relates to gel medicine field is and in particular to a kind of patch for soft tissue injury and preparation method thereof.
Background technology
Soft tissue injury, microcirculation disturbance, aseptic inflammation after being wound in tissue, and causes local swelling pain.With swollen
Swollen, pain is main performance.Acute stage, local oozing of blood, edema, sharp ache.Late period be likely to occur muscle, the adhesion of tendon,
Ischemic contracture, periarthritises, or even cause joint stiffness.Sprain finger indirect violence make limbs and periarticular fascia,
Muscle, ligament excessive distortion, tractive, cause damage or tear.Mostly occur in joint and periarticular tissue.Contusion refers to directly
Violence is hit or is collided limbs local, causes subcutaneous tissue at this, muscle, tendon equivalent damage.Based on direct damaged part.
Neck, shoulder, elbow, wrist, refer between, wrist, knee joint, stamp, the position such as waist all can cause bruise.Wherein waist bruise is most common, is more common in
Between twenty and fifty.Treatment is mainly based on blood circulation promoting and blood stasis dispelling, channels sootheing and network vessel quickening, reducing swelling and alleviating pain.
On clinical treatment, primary treatments are the oral medicines such as detumescence, blood circulation promoting and blood stasis dispelling or are sealed using injection, local at present
Apolipsis pain etc..And medicine of subsiding a swelling all has larger zest to patient's stomach, blood vessel etc., blood circulation promoting and blood stasis dispelling is administered orally, injection drug short-term
The effect of interior medicine can not go directly disease and price is more expensive, partial closure's analgesic uses non-steroid antiinflammatory drug, hormone substantially
Class medicine, long-term taking has certain toxic and side effects, even more cures the symptoms, not the disease in the selection of Therapeutic Method, and curative effect is not good enough,
Bring greatly painful and spirit, burden economically to patient.Accordingly, it would be desirable to a kind of for soft tissue injury, take effect
Hurry up, good effect, there is no the patch for soft tissue injury of toxic and side effects.
Content of the invention
The present invention is intended to provide a kind of for soft tissue injury, instant effect, good effect, there is no toxic and side effects, and to skin
Skin stimulates the little patch for soft tissue injury.
The technical scheme is that：
A kind of patch for soft tissue injury, is made up of non-woven fabrics backing layer, load medicinal gel layer, release paper cover layer, described
Carry medicinal gel layer to be made up of the raw material of following weight：Polymer substance 5-15 part, cross-linking agent and cross-linking regulator 0.2-
2 parts, wetting agent 10-30 part, Radix Angelicae Dahuricae oil 0.01-0.05 part, peach kernel oil 0.01-0.05 part, Semen Coicis oil 0.01-0.05 part, thin
Lotus brain 0.01-0.05 part, ethanol 0.2-1 part, purified water 55-85 part.
Further, described load medicinal gel layer is made up of the raw material of following weight：10 parts of polymer substance, crosslinking
Agent and 1 part of cross-linking regulator, 20 parts of wetting agent, 0.03 part of Radix Angelicae Dahuricae oil, 0.03 part of peach kernel oil, 0.03 part of Semen Coicis oil, Mentholum
0.03 part, 0.6 part of ethanol, 68.28 parts of purified water.
Further, described Radix Angelicae Dahuricae oil is obtained by following methods：
Weigh the Radix Angelicae Dahuricae to pulverize, using SCF-CO 2, condition is：Extraction kettle pressure is 30MPa, and extraction temperature is 55 DEG C；Point
It is 40 DEG C from temperature, I level separating still pressure is 10MPa, II grade of separating still pressure is 6MPa, CO2 flow velocity is 2.5L/min, extraction
Time is 5h, and separating still is collected and obtained grease, obtains Radix Angelicae Dahuricae oil.
Further, described peach kernel oil is obtained by following methods：
Weigh Semen Persicae to pulverize, using SCF-CO 2, condition is：Extraction kettle pressure is 25MPa, and extraction temperature is 50 DEG C；Point
It is 40 DEG C from temperature, I level separating still pressure is 8MPa, II grade of separating still pressure is 6MPa, and CO2 flow velocity is 2L/min, during extraction
Between be 4h, separating still collect obtain grease, obtain peach kernel oil.
Further, described Semen Coicis oil is obtained by following methods：
Take Semen Coiciss to add the water of 10 times amount, distillation extraction 6 hours, collect volatile oil, obtain Semen Coicis oil.
Further, described polymer substance is selected from hyaluronic acid, collagen protein, sodium alginate, Carbomer, carboxymethyl
One or more of cellulose, Hypromellose, sodium polyacrylate, gelatin, polyvinyl alcohol, Polyvinylpyrrolidone mixed
Compound.
Further, described cross-linking agent is one or more of aluminum, aluminum chloride, aluminium sesquioxide, dihydroxyaluminum aminoacetate
Mixture, cross-linking regulator is the mixture of one or more of citric acid, tartaric acid, glacial acetic acid, citric acid, formic acid, hands over
The mass ratio of connection agent and cross-linking regulator is 1: 0.5-5.
Further, described wetting agent is selected from one or more of glycerol, propylene glycol, Polyethylene Glycol, Vitamin E
Mixture.
Present invention also offers a kind of preparation method of the patch for soft tissue injury：
(1) polymer substance and cross-linking regulator is taken to add purified water, stirring and dissolving；
(2) cross-linking agent and wetting agent mixing and stirring are taken；
(3) the two solution mix and blends making above-mentioned (1), (2), make uniform gel；
(4) take Radix Angelicae Dahuricae oil, peach kernel oil, Semen Coicis oil, the dissolving of Mentholum ethanol, add in gel, stir；
(5) by coated for the above-mentioned gel preparing on backing layer, release paper cover layer simultaneously；
(6) cut into required size and shape, packaging.
The present invention is pasted on the body parts such as neck, shoulder, waist and leg, and scapulohumeral periarthritis, cervical spondylosiss, lumbar muscle strain and traumatic injury can be damaged
The soft tissue injury cooling cold compress of the initiations such as wound, effect is very fast, scapulohumeral periarthritis, cervical spondylosiss, lumbar muscle strain, traumatic injury is all had excellent
Different curative effect.
Specific embodiment
The mixture of one or more of polymer substance and cross-linking regulator is taken to add purified water, stirring and dissolving；Take friendship
The mixture of connection one or more of agent and wetting agent, stirs；By both solution mix and blend uniformly gels；
Take Radix Angelicae Dahuricae oil, peach kernel oil, Semen Coicis oil, the dissolving of Mentholum ethanol, add in gel, stir；Prepare above-mentioned
Gel coated on backing layer, release paper cover layer simultaneously；Cut into required size and shape, packaging.
The different ratio of gel component sees below embodiment：
Embodiment 1
Take 5 parts of mass fraction collagen protein, 5 parts of polyvinyl alcohol, 20 parts of glycerol, 0.5 part of aluminium sesquioxide, tartaric acid 0.5
Part, 0.03 part of Radix Angelicae Dahuricae oil, 0.03 part of peach kernel oil, 0.03 part of Semen Coicis oil, 0.03 part of Mentholum, 0.6 part of ethanol, purified water
68.28 parts, make the patch for soft tissue injury.
Embodiment 2
Take 5 parts of mass fraction collagen protein, 10 parts of glycerol, 0.1 part of aluminium sesquioxide, 0.1 part of tartaric acid, Radix Angelicae Dahuricae oil 0.01
Part, 0.01 part of peach kernel oil, 0.01 part of Semen Coicis oil, 0.01 part of Mentholum, 0.2 part of ethanol, 55 parts of purified water, make for soft
The patch of tissue injury.
Embodiment 3
Take 5 parts of mass fraction collagen protein, 5 parts of polyvinyl alcohol, 5 parts of gelatin, 30 parts of glycerol, 1 part of aluminium sesquioxide, winestone
1 part of acid, 0.05 part of Radix Angelicae Dahuricae oil, 0.05 part of peach kernel oil, 0.05 part of Semen Coicis oil, 0.05 part of Mentholum, 1 part of ethanol, purified water
75 parts, make the patch for soft tissue injury.
At present following test is carried out to the present invention：
Test patch：Patch obtained by embodiment 1（Containing 0.03 part of Radix Angelicae Dahuricae oil, 0.03 part of peach kernel oil, Semen Coicis oil 0.03
Part）；Blank patch（It is obtained by embodiment 1 methods described, without Radix Angelicae Dahuricae oil, peach kernel oil and Semen Coicis oil）；Single Radix Angelicae Dahuricae oil
Patch（It is obtained by embodiment 1 methods described, containing 0.09 part of Radix Angelicae Dahuricae oil, without peach kernel oil, Semen Coicis oil）；Single peach kernel oil
Patch（It is obtained by embodiment 1 methods described, containing 0.09 part of peach kernel oil, without Radix Angelicae Dahuricae oil, Semen Coicis oil）；Single Semen Coiciss
Oily patch（It is obtained by embodiment 1 methods described, containing 0.09 part of Semen Coicis oil, without Radix Angelicae Dahuricae oil, peach kernel oil）.
Test method：Test patch is affixed on affected part, a piece of daily.Observe after using 1 day, after 3 days, after 5 days
Records appraisal.
Test packet：Now by cardinal symptom sign be pain, swelling, blood stasis, tenderness, 100 soft group of movable function obstacle
Knit injured patient and be randomly divided into following 5 groups（Every group of 20 people）Tested：1 group of embodiment（Patch obtained by patch embodiment 1）；
Blank control group（The blank patch of patch）；Radix Angelicae Dahuricae line of oils（Patch single Radix Angelicae Dahuricae oil patch）；Semen Persicae line of oils（Patch single peach kernel oil patch）；
Semen Coiciss line of oils（Patch single Semen Coicis oil patch）；
Evaluation criterion：Effective：Pain, swelling, blood stasis, tenderness symptom have certain mitigation, and dysfunction has been recovered；Rehabilitation：Pain
Bitterly, swelling, blood stasis, tenderness symptom disappear, and dysfunction disappears.Invalid：Pain, swelling, blood stasis, tenderness, dysfunction etc. are all
No improve.
Observed result：
After 1 day, 1 group of effective number of embodiment is 8 people；Blank control group is effective to be 0 people；Radix Angelicae Dahuricae line of oils is effective to be 2 people；Fructus Persicae
Core line of oils is effective to be 2 people；Semen Coiciss line of oils is effective to be 0 people；Each group rehabilitation is 0 people.
After 3 days, 1 group of rehabilitation 4 people of embodiment, remaining effective 12 people；Blank control group is effective to be 5 people；Radix Angelicae Dahuricae line of oils
Effective is 8 people, another rehabilitation 2 people；Semen Persicae line of oils is effective to be 6 people, another rehabilitation 1 people；Semen Coiciss line of oils is effective to be 5 people, rehabilitation 0 people.
After 5 days, 1 group of embodiment rehabilitation 8 people altogether, remaining effective 12 people, invalid 0 people；Blank control group is effective to be 10
People, 0 people's rehabilitation, invalid 10 people；Radix Angelicae Dahuricae line of oils is effective to be 11 people, altogether rehabilitation 4 people, invalid 5 people；Effective 11 people of Semen Persicae line of oils, altogether
Rehabilitation 3 people, invalid 6 people；Semen Coiciss line of oils is effective to be 10 people, altogether rehabilitation 2 people, invalid 8 people.
After 2 weeks, 1 group of embodiment rehabilitation 16 people altogether, remaining effective 4 people；Blank control group residue is effective to be 11 people, altogether
5 people's rehabilitations, invalid 4 people；Radix Angelicae Dahuricae line of oils residue is effective to be 11 people, altogether rehabilitation 7 people, invalid 2 people；Semen Persicae line of oils remaining effective 10
People, rehabilitation 7 people altogether, invalid 3 people；Semen Coiciss line of oils is effective to be 10 people, altogether rehabilitation 6 people, invalid 4 people.
In process of the test, patient is not had to have phenomena of cutaneous irritation.
Can be obtained by above-mentioned result of the test, under identical dosage, the embodiment of the present invention 1 patch（Compound recipe）Treatment soft tissue
Damage effect and duration is substantially better than each single medicine, pharmaceutical composition of the present invention is described, mutual by three taste difference Chinese medicines
Compatibility, meets Chinese medical theory, has played synergistic function, obtains the effect more preferably treating soft tissue injury.
The present invention has a preferable curative effect to treatment soft tissue injury, instant effect, good effect, does not have toxic and side effects, and to skin
Skin stimulates little.
Claims (9)
1. a kind of patch for soft tissue injury, is made up of non-woven fabrics backing layer, load medicinal gel layer, release paper cover layer, its
It is characterised by：Described load medicinal gel layer is made up of the raw material of following weight：Polymer substance 5-15 part, cross-linking agent and friendship
Connection regulator 0.2-2 part, wetting agent 10-30 part, Radix Angelicae Dahuricae oil 0.01-0.05 part, peach kernel oil 0.01-0.05 part, Semen Coicis oil
0.01-0.05 part, Mentholum 0.01-0.05 part, ethanol 0.2-1 part, purified water 55-85 part.
2. the patch for soft tissue injury according to claim 1 it is characterised in that：Described load medicinal gel layer is by following
The raw material of weight is made：10 parts of polymer substance, cross-linking agent and 1 part of cross-linking regulator, 20 parts of wetting agent, Radix Angelicae Dahuricae oil
0.03 part, 0.03 part of peach kernel oil, 0.03 part of Semen Coicis oil, 0.03 part of Mentholum, 0.6 part of ethanol, 68.28 parts of purified water.
3. the patch for soft tissue injury according to claim 1 and 2 it is characterised in that：Described Radix Angelicae Dahuricae oil is by following
Method is obtained：
Weigh the Radix Angelicae Dahuricae to pulverize, using SCF-CO 2, condition is：Extraction kettle pressure is 30MPa, and extraction temperature is 55 DEG C；Point
It is 40 DEG C from temperature, I level separating still pressure is 10MPa, II grade of separating still pressure is 6MPa, CO2 flow velocity is 2.5L/min, extraction
Time is 5h, and separating still is collected and obtained grease, obtains Radix Angelicae Dahuricae oil.
4. the patch for soft tissue injury according to claim 1 and 2 it is characterised in that：Described peach kernel oil is by following
Method is obtained：
Weigh Semen Persicae to pulverize, using SCF-CO 2, condition is：Extraction kettle pressure is 25MPa, and extraction temperature is 50 DEG C；Point
It is 40 DEG C from temperature, I level separating still pressure is 8MPa, II grade of separating still pressure is 6MPa, and CO2 flow velocity is 2L/min, during extraction
Between be 4h, separating still collect obtain grease, obtain peach kernel oil.
5. according to described in claim 1 or 2 for soft tissue injury patch it is characterised in that：Described Semen Coicis oil is by following
Method is obtained：
Take Semen Coiciss to add the water of 10 times amount, distillation extraction 6 hours, collect volatile oil, obtain Semen Coicis oil.
6. a kind of patch for soft tissue injury according to claim 1 and 2 it is characterised in that：Described macromolecule
Material is selected from hyaluronic acid, collagen protein, sodium alginate, Carbomer, carboxymethyl cellulose, Hypromellose, polyacrylic acid
The mixture of one or more of sodium, gelatin, polyvinyl alcohol, Polyvinylpyrrolidone.
7. a kind of patch for soft tissue injury according to claim 1 and 2 it is characterised in that：Described cross-linking agent
It is the mixture of one or more of aluminum, aluminum chloride, aluminium sesquioxide, dihydroxyaluminum aminoacetate, cross-linking regulator is citric acid, winestone
The mass ratio of the mixture of one or more of acid, glacial acetic acid, citric acid, formic acid, cross-linking agent and cross-linking regulator is 1:
0.5-5.
8. a kind of patch for soft tissue injury according to claim 1 and 2 it is characterised in that：Described wetting agent
Mixture selected from one or more of glycerol, propylene glycol, Polyethylene Glycol, Vitamin E.
9. the preparation method of a kind of patch for soft tissue injury according to claim 1-8 any one, its feature
It is：Described preparation method is as follows：
(1) polymer substance and cross-linking regulator is taken to add purified water, stirring and dissolving；
(2) cross-linking agent and wetting agent mixing and stirring are taken；
(3) the two solution mix and blends making above-mentioned (1), (2), make uniform gel；
(4) take Radix Angelicae Dahuricae oil, peach kernel oil, Semen Coicis oil, the dissolving of Mentholum ethanol, add in gel, stir；
(5) by coated for the above-mentioned gel preparing on backing layer, release paper cover layer simultaneously；
(6) cut into required size and shape, packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611232586.XA CN106421540A (en) | 2016-12-28 | 2016-12-28 | Patch for soft tissue damage and preparation method of patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611232586.XA CN106421540A (en) | 2016-12-28 | 2016-12-28 | Patch for soft tissue damage and preparation method of patch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106421540A true CN106421540A (en) | 2017-02-22 |
Family
ID=58215508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611232586.XA Withdrawn CN106421540A (en) | 2016-12-28 | 2016-12-28 | Patch for soft tissue damage and preparation method of patch |
Country Status (1)
| Country | Link |
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| CN (1) | CN106421540A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107335391A (en) * | 2017-09-29 | 2017-11-10 | 哈尔滨理工大学 | A kind of preparation method of metal organogel for carrying medicament |
| CN110075343A (en) * | 2019-05-17 | 2019-08-02 | 江苏西宏生物医药有限公司 | Medical reparation skin cold compress patch of one kind and preparation method thereof |
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Cited By (2)
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|---|---|---|---|---|
| CN107335391A (en) * | 2017-09-29 | 2017-11-10 | 哈尔滨理工大学 | A kind of preparation method of metal organogel for carrying medicament |
| CN110075343A (en) * | 2019-05-17 | 2019-08-02 | 江苏西宏生物医药有限公司 | Medical reparation skin cold compress patch of one kind and preparation method thereof |
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Application publication date: 20170222 |