CN112057585A - Formula of patch containing multiple essential oils for treating pain in neck, shoulder, waist and leg and preparation method thereof - Google Patents

Formula of patch containing multiple essential oils for treating pain in neck, shoulder, waist and leg and preparation method thereof Download PDF

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Publication number
CN112057585A
CN112057585A CN202011064573.2A CN202011064573A CN112057585A CN 112057585 A CN112057585 A CN 112057585A CN 202011064573 A CN202011064573 A CN 202011064573A CN 112057585 A CN112057585 A CN 112057585A
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parts
essential oil
plaster
reaction kettle
waist
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李志耿
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Luoyang Xinzuobiao Biological Engineering Co ltd
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Luoyang Xinzuobiao Biological Engineering Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/254—Acanthopanax or Eleutherococcus
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/264—Aristolochia (Dutchman's pipe)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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Abstract

The invention discloses a patch formula containing multiple essential oils for treating neck, shoulder, waist and leg pain, which is prepared from the following components in parts by weight: 60-65 parts of plaster matrix, 1-4 parts of safflower essential oil, 1-4 parts of angelica essential oil, 1-2 parts of wintergreen essential oil, 1-2 parts of camphor tree essential oil, 1-2 parts of argy wormwood leaf essential oil, 1-2 parts of zedoary turmeric essential oil, 2-4 parts of scorpion, 2-4 parts of frankincense, 2-4 parts of myrrh, 2-4 parts of medicinal cyathula root, 2-4 parts of prepared common monkshood mother root, 2-4 parts of prepared kusnezoff monkshood root, 3-5 parts of garden balsam stem, 2-4 parts of clematis root, 1-3 parts of szechuan lovage rhizome, 2-4 parts of wooly datchmanspipe herb, 2-4 parts of common clubmoss herb, 2-5 parts of parasitic loranthus, 2-5 parts of acanthopanax bark and 1-3 parts of pseudo-ginseng The medicine has good effect of quickly relieving neck, shoulder, waist and leg arthralgia such as scapulohumeral periarthritis, lumbar muscle strain, lumbar disc herniation, waist and leg pain, arthritis, traumatic injury, sprain and contusion, hyperosteogeny, heel pain and the like.

Description

Formula of patch containing multiple essential oils for treating pain in neck, shoulder, waist and leg and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines and treatment of neck, shoulder, waist and leg pain, in particular to a formula of a patch containing various essential oils for treating neck, shoulder, waist and leg pain and a preparation method thereof.
Background
In life, many people suffer from soreness and pain in the waist; the pain is caused by many reasons, and can be generally generalized to soft tissue, cartilage, bone and inflammation according to the characteristics of age, sex, attack part and symptom; people with general soreness are usually pasted with pain-relieving plasters or oral pain-relieving medicines, the former easily causes skin allergy or may cause stomach discomfort.
Neck, shoulder, waist and leg pain are very common diseases, and the main causes are trauma, strain, cervical and lumbar disc herniation, which causes adjacent nerves to be pressed or stimulated, thereby generating a series of clinical symptoms such as numbness and pain of neck, shoulder, waist and lower limbs; pain in the neck, shoulders, waist and legs is a common symptom in most patients with herniated disc; the outer layer of the annulus fibrosus and the posterior longitudinal ligament are stimulated by nucleus pulposus, and pain, numbness and other symptoms are generated through nerve conduction, sometimes the symptoms are radiated to upper limbs and lower limbs, and reach hands or feet, and the pain is aggravated due to slight movement or body posture change; a few patients are accompanied by severe consequences such as dizziness, hypertension, syncope, incontinence of urine and feces, muscular atrophy of both lower limbs, incomplete paralysis and the like. Especially, when a patient gets up from bed in sleep, the patient with neck, shoulder, waist and leg pain feels stiff limbs, and the pain part of the neck, shoulder, waist and leg pain is aching for a long time and is very painful, if the patient is not treated in time, the patient can cause skeleton deformation, the life and the work of the patient are seriously influenced, and the subsequent medical treatment difficulty is deepened.
Furthermore, the traditional plaster patch for treating neck, shoulder, waist and leg pains has large medicinal odor and adverse reactions such as irritation or allergy to skin, and aiming at the problems, the essential oil is high in component, quick in medicinal effect and strong in permeability and is usually used for relieving pain, wherein the traditional Chinese medicine essential oil is a compound preparation of the essential oil and active ingredients of rare traditional Chinese medicinal materials; contains therapeutic components of Chinese medicinal materials, and also contains essential oil; regulating functions of internal organs, dredging channels and collaterals, eliminating lump, thoroughly eliminating focus on channels and collaterals, caring skin or treating diseases, and has dual effects of essential oil and Chinese medicinal materials; the health-care product can not only be used for leisure and health care, but also be used for conditioning meridian points or treating diseases, and is the most effective health-care product for conditioning or preventing sub-health at present; the natural, environment-friendly, quick-permeation, good effect, high efficiency and no side effect; therefore, aiming at the problems, a mild and non-irritant plaster patch which is synthesized by multiple essential oil additive components and multiple medicinal material components and is used for rapidly relieving neck, shoulder, waist and leg joint pain is needed.
Disclosure of Invention
The invention provides a patch containing various essential oils for treating neck, shoulder, waist and leg pains, which solves the problems, adopts 6 plant essential oil components for compatibility, has the effect of quickly relieving pain, is additionally provided with 15 traditional Chinese medicine components for effectively relieving pain, and has good effect of quickly relieving pain of neck, shoulder, waist and leg arthralgia, scapulohumeral periarthritis, lumbar muscle strain, lumbar disc herniation, waist and leg pain, arthritis, traumatic injury, sprain and contusion, hyperosteogeny, heel pain and the like.
In order to solve the technical problems, the invention adopts the technical scheme that: a patch formula containing various essential oils for treating neck, shoulder, waist and leg pain is prepared from the following components in parts by weight: 60-65 parts of plaster matrix, 1-4 parts of safflower essential oil, 1-4 parts of angelica essential oil, 1-2 parts of wintergreen essential oil, 1-2 parts of camphor tree essential oil, 1-2 parts of folium artemisiae argyi essential oil, 1-2 parts of curcuma zedoary essential oil, 2-4 parts of scorpion, 2-4 parts of frankincense, 2-4 parts of myrrh, 2-4 parts of radix cyathulae, 2-4 parts of prepared radix aconiti, 2-4 parts of prepared kusnezoff monkshood root, 3-5 parts of garden balsam stem, 2-4 parts of radix clematidis, 1-3 parts of ligusticum wallichii, 2-4 parts of wooly datchmanspipe herb, 2-4 parts of lycopodium clavatum, 2-5 parts of parasitic loranthus, 2-5 parts of cortex acanthopanacis and 1.
Preferably, the formula is prepared from the following components in parts by weight: 63 parts of plaster matrix, 3 parts of safflower essential oil, 3 parts of angelica essential oil, 1 part of wintergreen essential oil, 1 part of camphor tree essential oil, 1 part of folium artemisiae argyi essential oil, 1 part of zedoary essential oil, 3 parts of scorpion, 3 parts of frankincense, 3 parts of myrrh, 3 parts of radix cyathulae, 3 parts of prepared radix aconiti agrestis, 4 parts of garden balsam stem, 3 parts of radix clematidis, 2 parts of ligusticum wallichii, 3 parts of wooly datchmanspipe herb, 3 parts of lycopodium clavatum, 4 parts of loranthus parasiticus, 4 parts of cortex acanthopanacis and.
A preparation method of a patch containing multiple essential oils for treating neck, shoulder, waist and leg pain comprises the following steps:
(1) taking medicinal materials: 3 parts of scorpion, 3 parts of frankincense, 3 parts of myrrh, 3 parts of medicinal cyathula root, 3 parts of prepared common monkshood mother root, 3 parts of prepared kusnezoff monkshood root, 4 parts of garden balsam stem, 3 parts of clematis root, 2 parts of szechuan lovage rhizome, 3 parts of mollissima, 4 parts of Chinese taxillus twig, 3 parts of common clubmoss herb, 4 parts of cortex acanthopanacis and 2 parts of pseudo-ginseng are sequentially added into a reactor, and the traditional Chinese medicinal materials are extracted and concentrated into a traditional Chinese medicine extract by an ethanol hot reflux;
(2) glue melting: adding 63 parts of medicinal material plaster matrix into a plaster reaction kettle, setting the temperature of the plaster reaction kettle at 170 ℃, heating and melting the plaster matrix into hot melt adhesive solution, and keeping for later use;
(3) cooling: reducing the temperature of the plaster reaction kettle to 130 ℃, reducing the temperature of the hot melt adhesive solution to ensure the property of the medicine materials added subsequently, and cooling for later use;
(4) adding medicinal materials: adding the traditional Chinese medicine extract prepared in the step (1) into the plaster reaction kettle cooled in the step (3), keeping the temperature of the plaster reaction kettle at 130 ℃, ensuring that the stirring operation of the mixture is carried out while adding the traditional Chinese medicine extract, keeping the stirring speed of the plaster reaction kettle at 30 r/min, stirring at a constant speed for 30 min, and ensuring that the components of the traditional Chinese medicine extract and the hot melt adhesive are uniformly mixed;
(5) adding a penetrant: after the operation of the step (4) is finished, taking 2 parts of penetrant, starting to add the penetrant, keeping the temperature of the plaster reaction kettle at 130 ℃, ensuring that the mixture is stirred while the penetrant is added, keeping the stirring speed of the plaster reaction kettle at 30 r/min, and stirring at a constant speed for 30 min, so as to ensure that the penetrant and the hot melt adhesive mixture in the step (4) are uniformly mixed;
(6) secondary cooling: adjusting the temperature in the plaster reaction kettle to 110 ℃, ensuring the medicine property of the subsequently added essential oil, reducing the volatilization of the essential oil, and cooling for later use;
(7) adding essential oil: sequentially adding 3 parts of safflower essential oil, 3 parts of angelica essential oil, 1 part of wintergreen essential oil, 1 part of camphor tree essential oil, 1 part of folium artemisiae argyi essential oil and 1 part of curcuma zedoary essential oil into the plaster reaction kettle in the step (6), keeping the temperature at 110 ℃, accelerating the stirring operation speed while adding the essential oil components, keeping the stirring speed of the plaster reaction kettle at 50 r/min, stirring at a constant speed for 40 min, accelerating the uniform mixing of the essential oil components and the mixture in the step (6), reducing the volatilization amount of the essential oil, and forming mixed mucilage for later use;
(8) debugging the coating machine: checking whether the air pressure, the circulating water, the cooling fan, the positioning induction equipment and the like of the coating machine meet the standards or not, and ensuring the safety of preprocessing operation of the coating machine;
(9) coating: after the essential oil mixture in the step (7) is uniformly formed into mixed mucilage, coating to produce a patch coiled material, loading a cloth roll and a paper roll on a plaster coating machine, connecting a glue injection rubber tube to a coating hopper, starting glue injection, namely adding the mixed mucilage for standby in the step (7), and controlling the coating thickness to be 1.5mm and the speed to be 5 m/min; in the coating process, the coating effect is observed in real time, so that the surface of the plaster is smooth and clean, and the thickness of the plaster is uniform; sampling and measuring the thickness at regular time, wherein the sampling and measuring of the thickness are carried out for 1 time every 5 minutes, the thickness meets the process requirement, and the error does not exceed +/-5%;
(10) slitting: cutting the coiled material prepared in the coating process in the step (9) into medicine cores with proper sizes according to the technical requirements and the size standards required by the patch, picking out the medicine cores with unqualified thicknesses or other defects during cutting, and storing the qualified medicine cores for later use;
(11) synthesizing: taking a prepared non-woven fabric layer with a proper size, uncovering the non-woven fabric layer of the plaster support sheet, sticking the medicine core remained in the step (10) to the non-woven fabric layer, and then extruding to complete the synthesis of the plaster patch.
Preferably, the reactor is a hot reflux extraction concentration tank.
Preferably, the penetrating agent is laurocapram, and the product is a non-polar transdermal enhancer, which can soften cutin, enhance permeability, make the drug penetrate skin barrier, increase local or systemic blood concentration, and improve bioavailability of the preparation; has transdermal promoting effect on lipophilic and hydrophilic drugs.
Preferably, the non-woven fabrics layer adopts mesh ventilative spunlace cloth, so set up, adopts mesh ventilative spunlace cloth, and the material is soft, and after this plaster patch pasted and applied the affected part, the non-woven fabrics mesh around the medicine core can be suitably ventilative, reduces the skin discomfort.
Preferably, the plaster substrate is a solid hot-melt pressure-sensitive adhesive plaster substrate.
The invention has the following beneficial technical effects: the patch formula is mainly used for sub-health people with neck, shoulder, waist and leg pain, stabbing pain, stiffness, numbness and even arthrocele and unsmooth flexion and extension caused by long-term blockage of channels and collaterals by wind-cold-dampness and qi stagnation and blood stasis; the raw kusnezoff monkshood root and the raw monkshood monarch drug which are pungent and hot in flavor and are scattered are added in the formula, the combination of the two drugs has the effects of dredging and relaxing muscles and joints, opening and closing striae and expelling cold and dampness, and is good in dispelling wind, removing dampness and relieving pain, and has good relieving effects on blood stasis pain, traumatic injury and fracture blood stasis and swelling, and Chuanwu has obvious anti-inflammatory and analgesic effects through modern researches, and has good effects on arthritis, lumbar muscle strain, sciatica, fibrositis and mucosa surface anesthesia; the combination of clematis root, mollissima, lycopodium clavatum and garden balsam stem has the functions of expelling wind-damp, relaxing muscles and tendons and dredging collaterals; the prepared frankincense, the prepared myrrh, the angelica, the safflower, the ligusticum wallichii and the pseudo-ginseng are used together, have the effects of promoting qi and blood circulation, removing blood stasis and relieving pain, have better effects on relieving swelling and numbness of limbs and joints, stabbing pain, blood stasis and pain and strain sprain, and are used as ministerial medicines in the formula; the Chinese medicinal herbs of the loranthus parasiticus and the acanthopanax bark are used as adjuvant drugs in a formula for expelling wind-damp, tonifying liver and kidney, strengthening muscles and bones, treating liver and kidney injury due to wind-cold-dampness, weakness of muscles and bones and soreness and weakness of waist and knees, and tonifying liver and kidney and strengthening tendons and bones of the radix cyathulae, which have descending properties and can promote diuresis, promote blood circulation and remove blood stasis.
Wherein, the safflower essential oil: the safflower is the dried flower of the safflower of the compositae, has the effects of pungent and warm nature, enters the blood system of heart and liver, promotes blood circulation, dredges channels, removes stasis and relieves pain, and is good for treating various diseases of blood stasis blockage.
Angelica essential oil: the angelica essential oil is a traditional Chinese medicine for generating and activating blood, has the effects of enriching blood and activating blood, regulating menstruation and relieving pain, and relaxing bowel, acts on skin and promotes the generation of hemoglobin and red blood cells.
And (3) ilex essential oil: the wintergreen essential oil has the effects of stimulating, diminishing inflammation, relieving pain and the like, and can promote local blood circulation; it can be used for treating acute rheumatic arthritis, lumbago, myalgia, neuralgia, and itching, and can be used as liniment for treating rheumatalgia and topical acute rheumatic arthritis.
Camphor tree essential oil: the camphor tree essential oil is a balanced essential oil, can sooth the state of the essential channels, particularly the essential channels of numb due to depression, is beneficial to the mental state in the recovery period, is obviously beneficial to psychosomatic symptoms such as psychoneurosis and has the following effects: relieving pain, resisting depression, resisting bacteria, resisting spasm, benefiting heart, dispelling flatulence, promoting urination, reducing fever, increasing blood pressure, killing parasite, relieving constipation, warming skin, stimulating, promoting perspiration, expelling parasites, and treating wound.
And (3) argy wormwood leaf essential oil: has the functions of regulating qi and blood and expelling cold and dampness; warming channels, stopping bleeding and preventing miscarriage, and carrying pottery: "pounding leaves to moxibustion for many diseases and stopping blood damage", is mainly used for the following reasons: warming meridians to stop bleeding, dispelling cold, removing dampness and relieving pain.
Zedoary turmeric oil: has the effects of promoting qi circulation, removing blood stasis, resolving food stagnation and relieving pain. It is commonly indicated for blood, qi and heart pain, food stagnation, abdominal distention and pain, amenorrhea due to blood stagnation, and traumatic injury.
Scorpion: pungent and mild; entering liver meridian; calming endogenous wind, relieving spasm, dredging collaterals, relieving pain, counteracting toxic pathogen, resolving hard mass, and having pharmacological actions: expelling wind and relieving spasm, the pharmacology is: (1) and (3) resisting convulsion: animal experiments show that the composition has effects in resisting convulsion caused by nitrate such as sunconine, pure nicotine, and pentazine; (2) sedation: has obvious sedative effect on conscious animals. (Chinese medicine is a major organ of the whole world, Chinese medicine reservoir, and the efficacy and action of Chinese medicine).
Frankincense: pungent, bitter and warm; heart, liver and spleen meridians entered; promote blood circulation, move qi and alleviate pain, resolve swelling and promote tissue regeneration. (Chinese medicine is a major organ of the whole world, Chinese medicine reservoir, and the efficacy and action of Chinese medicine).
Myrrh: the main treatment is as follows: carbuncle, deep-rooted carbuncle, swelling and pain, pain in heart, abdomen, tendons and bones, blood damage, wound healing and tissue regeneration after external use; the efficacy and the effect are as follows: promoting blood circulation, removing blood stasis and relieving pain; it has astringent and antiinflammatory effects when applied topically. In addition, the product has different degrees of inhibition effect on various dermatophytes; the ratio of 1: 3000-1: the concentration of 300 can inhibit tubercle bacillus. (Chinese medicine is a major organ of the whole world, Chinese medicine reservoir, and the efficacy and action of Chinese medicine).
Radix cyathulae: mild in nature, sweet and slightly bitter in taste, non-toxic and enters liver and kidney meridians; the main treatment is as follows: dispelling pathogenic wind, promoting diuresis, dredging channels, and promoting blood circulation; it is indicated for wind-damp, lumbar and knee pain, atrophy and contracture of foot, stranguria with blood, hematuria, amenorrhea and abdominal mass. Can be used for treating amenorrhea, abdominal mass, retention of exocytosis, arthralgia, flaccidity of feet, spasm of tendons, stranguria with hematuria and blood, and traumatic injury. (Chinese medicine is a major organ of the whole world, Chinese medicine reservoir, and the efficacy and action of Chinese medicine).
Radix aconiti preparata: pungent, bitter and hot in flavor; heart, liver, kidney, spleen channels; dispel wind and dampness, warm meridians and alleviate pain. (Chinese medicine is a major organ of the whole world, Chinese medicine reservoir, and the efficacy and action of Chinese medicine).
Preparing kusnezoff monkshood root: pungent, bitter and hot in flavor; heart, liver, kidney, spleen channels; dispel wind and remove dampness, warm meridians and relieve pain, mainly treat diseases: can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, and hernia of cold type. (Chinese medicine is a major organ of the whole world, Chinese medicine reservoir, and the efficacy and action of Chinese medicine).
Garden balsam stem: sweet in taste and non-toxic; the main treatment is as follows: expelling wind, removing dampness, relaxing muscles and tendons, promoting blood circulation, and relieving pain. For treating rheumatic arthralgia, contracture of muscles and bones, cold-dampness beriberi, sore, tinea and pyogenic infections; handbook of Chinese herbal medicine of Shandong: expelling wind-damp, promoting blood circulation and relieving pain. (Chinese medicine is a major organ of the whole world, Chinese medicine reservoir, and the efficacy and action of Chinese medicine).
Clematis root: dispel wind-damp, dredge meridians and collaterals, its function is to ease pain; animal experiments preliminarily find that the product also has a certain anesthetic effect; the in vitro test has antibacterial effect on typhoid bacillus, enteritis bacillus, dysentery bacillus Sonneri, etc.; the main treatment is as follows: rheumatic arthralgia, paralysis and numbness; dispel wind, dispel dampness, promote qi circulation and dredge collaterals. (Chinese medicine is a major organ of the whole world, Chinese medicine reservoir, and the efficacy and action of Chinese medicine).
Ligusticum wallichii: it is an important herb for activating blood and alleviating pain; "walk without guard"; "blood-qi-in-blood-qi-tonifying" refers to the condition of activating blood circulation and promoting qi circulation to relieve depression; "can dredge the blood vessels of the whole body", "ascend the head and eyes, descend the menstrual fluid and open the stagnation"; promoting blood circulation to alleviate pain and dispelling exogenous wind, especially for relieving headache; chuan Xiong is stir-baked to remove oil, unprocessed for arthralgia-syndrome. (Chinese medicine is a major organ of the whole world, Chinese medicine reservoir, and the efficacy and action of Chinese medicine).
Herba Aristolochiae Mollissimae: decoction piece New references: bitter and neutral. The main treatment is as follows: treating rheumatic arthralgia, abdominal pain, malaria, carbuncle and swelling; decoction piece New references: dispelling wind arthralgia, dredging collaterals, and treating arthralgia; [ Pharmacology ] is effective in experimental arthritis of rat, and herba Aristolochiae volatile koji and total alkaloids have obvious prevention effect on egg white arthritis of rat, and non-alkaloid part is ineffective, and cold soaking agent is precipitated for 1 time with ethanol to obtain preparation with effect on egg white arthritis and formaldehyde arthritis. (Chinese medicine is a major organ of the whole world, Chinese medicine reservoir, and the efficacy and action of Chinese medicine).
Parasitic loranthus: nature and taste: bitter and flat; meridian tropism: entering liver and kidney meridians; the functions are as follows: nourishing liver and kidney, removing rheumatism, strengthening tendons and bones, nourishing blood, and preventing miscarriage; the main treatment is as follows: pain in the loins and knees, weakness of tendons and bones, fetal movement and fetal leakage; the clinical application is as follows: for rheumatic arthralgia, it is suitable for rheumatic arthritis and rheumatic myositis with symptoms of soreness of waist, pain, arthralgia and other blood deficiency, and has effects of promoting blood circulation, relaxing muscles and tendons, activating collaterals, and relieving pain. (Chinese medicine is a major organ of the whole world, Chinese medicine reservoir, and the efficacy and action of Chinese medicine).
B, common clubmoss herb: nature and taste: bitter, pungent and warm; the functions are as follows: expelling wind and cold, removing dampness and swelling, relaxing muscles and tendons, and promoting blood circulation; the main treatment is as follows: arthralgia due to wind-cold-dampness, arthralgia, numb and edema of skin, and traumatic injury. (Chinese medicine is a major organ of the whole world, Chinese medicine reservoir, and the efficacy and action of Chinese medicine).
Cortex acanthopanacis: nature and taste: pungent, bitter and warm; meridian tropism: entering liver and kidney meridians; the functions are as follows: dispelling wind-damp, strengthening tendons and bones; the main treatment is as follows: rheumatic arthralgia, weak waist and knees, beriberi and edema; dispel wind-damp, tonify liver and kidney, strengthen tendons and bones, so it is considered as an analgesic with strong action. (Chinese medicine is a major organ of the whole world, Chinese medicine reservoir, and the efficacy and action of Chinese medicine).
Pseudo-ginseng: nature and taste: sweet, slightly bitter and warm; meridian tropism: entering liver and stomach meridians; the functions are as follows: hemostasis, blood stasis removal, detumescence and hemostasis; the efficacy and the effect are as follows: stopping bleeding, removing blood stasis, relieving swelling and pain. The pharmacology is as follows: 1. hemostasis is carried out; the Notoginseng radix warm infusion can shorten rabbit blood coagulation time, and has effect in contracting blood vessel; 2. diminishing inflammation; 3. the notoginseng water decoction has obvious inhibition effect on experimental arthritis of rats. (Chinese medicine is a major organ of the whole world, Chinese medicine reservoir, and the efficacy and action of Chinese medicine).
The components are compatible for use, are mainly used for sub-health people with neck, shoulder, waist and leg pain, stabbing pain, stiffness, numbness and even joint swelling, bending and stretching disadvantages caused by long-term blockage of channels and collaterals by wind-cold-dampness and qi stagnation and blood stasis, and can achieve the effect of quickly relieving the neck, shoulder, waist and leg pain.
Detailed Description
Example 1: a patch formula containing various essential oils for treating neck, shoulder, waist and leg pain is prepared from the following components in parts by weight: 60 parts of plaster matrix, 1 part of safflower essential oil, 1 part of angelica essential oil, 1 part of wintergreen essential oil, 1 part of camphor tree essential oil, 1 part of folium artemisiae argyi essential oil, 1 part of zedoary essential oil, 2 parts of scorpion, 2 parts of frankincense, 2 parts of myrrh, 2 parts of radix cyathulae, 2 parts of prepared radix aconiti agrestis, 3 parts of garden balsam stem, 2 parts of radix clematidis, 1 part of ligusticum wallichii, 2 parts of wooly datchmanspipe herb, 2 parts of lycopodium clavatum, 2 parts of loranthus parasiticus, 2 parts of cortex acanthopanacis and.
A preparation method of a patch containing multiple essential oils for treating neck, shoulder, waist and leg pain comprises the following steps:
(1) taking medicinal materials: 2 parts of scorpion, 2 parts of frankincense, 2 parts of myrrh, 2 parts of medicinal cyathula root, 2 parts of prepared common monkshood mother root, 2 parts of prepared kusnezoff monkshood root, 3 parts of garden balsam stem, 2 parts of clematis root, 1 part of szechuan lovage rhizome, 2 parts of mollissima, 2 parts of common clubmoss herb, 2 parts of Chinese taxillus twig, 2 parts of cortex acanthopanacis and 1 part of pseudo-ginseng are sequentially added into a reactor, the reactor is a hot reflux extraction and concentration tank, the traditional Chinese medicinal materials are extracted and concentrated into a traditional Chinese medicine extract by an ethanol hot;
(2) glue melting: 60 parts of medicinal plaster matrix is taken and put into a plaster reaction kettle, the temperature of the plaster reaction kettle is set to be 170 ℃, the plaster matrix is heated and melted into hot melt adhesive solution, and the hot melt adhesive solution is reserved for standby application, wherein the plaster matrix is solid hot melt pressure sensitive adhesive plaster matrix;
(3) cooling: reducing the temperature of the plaster reaction kettle to 130 ℃, reducing the temperature of the hot melt adhesive solution to ensure the property of the medicine materials added subsequently, and cooling for later use;
(4) adding medicinal materials: adding the traditional Chinese medicine extract prepared in the step (1) into the plaster reaction kettle cooled in the step (3), keeping the temperature of the plaster reaction kettle at 130 ℃, ensuring that the stirring operation of the mixture is carried out while adding the traditional Chinese medicine extract, keeping the stirring speed of the plaster reaction kettle at 30 r/min, stirring at a constant speed for 30 min, and ensuring that the components of the traditional Chinese medicine extract and the hot melt adhesive are uniformly mixed;
(5) adding a penetrant: after the operation of step (4) is finished, taking 2 parts of penetrant, starting to add the penetrant, wherein the penetrant is laurocapram, keeping the temperature of a plaster reaction kettle at 130 ℃, ensuring that the mixture is stirred while the penetrant is added, keeping the stirring speed of the plaster reaction kettle at 30 r/min, uniformly stirring for 30 min, and ensuring that the penetrant and the hot melt adhesive mixture in step (4) are uniformly mixed; laurone: it can soften cutin, enhance permeability, make medicine penetrate skin barrier, increase local or systemic blood concentration, and improve bioavailability of preparation; has transdermal promoting effect on lipophilic and hydrophilic drugs;
(6) secondary cooling: adjusting the temperature in the plaster reaction kettle to 110 ℃, ensuring the medicine property of the subsequently added essential oil, reducing the volatilization of the essential oil, and cooling for later use;
(7) adding essential oil: sequentially adding 1 part of safflower essential oil, 1 part of angelica essential oil, 1 part of wintergreen essential oil, 1 part of camphor tree essential oil, 1 part of folium artemisiae argyi essential oil and 1 part of curcuma zedoary essential oil into the plaster reaction kettle in the step (6), keeping the temperature at 110 ℃, accelerating the stirring operation speed while adding the essential oil components, keeping the stirring speed of the plaster reaction kettle at 50 r/min, stirring at a constant speed for 40 min, accelerating the uniform mixing of the essential oil components and the mixture in the step (6), reducing the volatilization amount of the essential oil, and forming mixed mucilage for later use;
(8) debugging the coating machine: checking whether the air pressure, the circulating water, the cooling fan, the positioning induction equipment and the like of the coating machine meet the standards or not, and ensuring the safety of preprocessing operation of the coating machine;
(9) coating: after the essential oil mixture in the step (7) is uniformly formed into mixed mucilage, coating to produce a patch coiled material, loading a cloth roll and a paper roll on a plaster coating machine, connecting a glue injection rubber tube to a coating hopper, starting glue injection, namely adding the mixed mucilage for standby in the step (7), and controlling the coating thickness to be 1.5mm and the speed to be 5 m/min; in the coating process, the coating effect is observed in real time, so that the surface of the plaster is smooth and clean, and the thickness of the plaster is uniform; sampling and measuring the thickness at regular time, wherein the sampling and measuring of the thickness are carried out for 1 time every 5 minutes, the thickness meets the process requirement, and the error does not exceed +/-5%;
(10) slitting: cutting the coiled material prepared in the coating process in the step (9) into medicine cores with proper sizes according to the technical requirements and the size standards required by the patch, picking out the medicine cores with unqualified thicknesses or other defects during cutting, and storing the qualified medicine cores for later use;
(11) synthesizing: taking a prepared non-woven fabric layer with a proper size, uncovering the non-woven fabric layer of the plaster support sheet, sticking the medicine core remained in the step (10) to the non-woven fabric layer, and then extruding to complete the synthesis of the plaster patch; wherein the non-woven fabric layer is made of mesh breathable spunlace fabric.
Example 2: a patch formula containing various essential oils for treating neck, shoulder, waist and leg pain is prepared from the following components in parts by weight: 65 parts of plaster matrix, 4 parts of safflower essential oil, 4 parts of angelica essential oil, 2 parts of wintergreen essential oil, 2 parts of camphor tree essential oil, 2 parts of folium artemisiae argyi essential oil, 2 parts of zedoary essential oil, 4 parts of scorpion, 4 parts of frankincense, 4 parts of myrrh, 4 parts of radix cyathulae, 4 parts of prepared radix aconiti agrestis, 5 parts of garden balsam stem, 4 parts of radix clematidis, 3 parts of ligusticum wallichii, 4 parts of wooly datchmanspipe herb, 4 parts of lycopodium clavatum, 5 parts of loranthus parasiticus, 5 parts of cortex acanthopanacis and.
A preparation method of a patch containing multiple essential oils for treating neck, shoulder, waist and leg pain comprises the following steps:
(1) taking medicinal materials: 4 parts of scorpion, 4 parts of frankincense, 4 parts of myrrh, 4 parts of medicinal cyathula root, 4 parts of prepared common monkshood mother root, 4 parts of prepared kusnezoff monkshood root, 5 parts of garden balsam stem, 4 parts of clematis root, 3 parts of szechuan lovage rhizome, 4 parts of mollissima, 4 parts of common clubmoss herb, 5 parts of Chinese taxillus twig, 5 parts of cortex acanthopanacis and 3 parts of pseudo-ginseng are sequentially added into a reactor, the reactor is a hot reflux extraction and concentration tank, the traditional Chinese medicinal materials are extracted and concentrated into a traditional Chinese medicine extract by an ethanol hot;
(2) glue melting: adding 65 parts of medicinal material plaster matrix into a plaster reaction kettle, setting the temperature of the plaster reaction kettle at 170 ℃ until the plaster matrix is heated and melted into hot melt adhesive solution, and keeping for later use, wherein the plaster matrix is solid hot melt pressure sensitive adhesive plaster matrix;
(3) cooling: reducing the temperature of the plaster reaction kettle to 130 ℃, reducing the temperature of the hot melt adhesive solution to ensure the property of the medicine materials added subsequently, and cooling for later use;
(4) adding medicinal materials: adding the traditional Chinese medicine extract prepared in the step (1) into the plaster reaction kettle cooled in the step (3), keeping the temperature of the plaster reaction kettle at 130 ℃, ensuring that the stirring operation of the mixture is carried out while adding the traditional Chinese medicine extract, keeping the stirring speed of the plaster reaction kettle at 30 r/min, stirring at a constant speed for 30 min, and ensuring that the components of the traditional Chinese medicine extract and the hot melt adhesive are uniformly mixed;
(5) adding a penetrant: after the operation of step (4) is finished, taking 2 parts of penetrant, starting to add the penetrant, wherein the penetrant is laurocapram, keeping the temperature of a plaster reaction kettle at 130 ℃, ensuring that the mixture is stirred while the penetrant is added, keeping the stirring speed of the plaster reaction kettle at 30 r/min, uniformly stirring for 30 min, and ensuring that the penetrant and the hot melt adhesive mixture in step (4) are uniformly mixed; laurone: it can soften cutin, enhance permeability, make medicine penetrate skin barrier, increase local or systemic blood concentration, and improve bioavailability of preparation; has transdermal promoting effect on lipophilic and hydrophilic drugs;
(6) secondary cooling: adjusting the temperature in the plaster reaction kettle to 110 ℃, ensuring the medicine property of the subsequently added essential oil, reducing the volatilization of the essential oil, and cooling for later use;
(7) adding essential oil: taking 4 parts of safflower essential oil, 4 parts of angelica essential oil, 2 parts of wintergreen essential oil, 2 parts of camphor tree essential oil, 2 parts of folium artemisiae argyi essential oil and 2 parts of curcuma zedoary essential oil, sequentially adding the materials into the plaster reaction kettle in the step (6), keeping the temperature at 110 ℃, accelerating the stirring operation speed while adding the essential oil components, keeping the stirring speed of the plaster reaction kettle at 50 r/min, stirring at a constant speed for 40 min, accelerating the uniform mixing of the essential oil components and the mixture in the step (6), reducing the volatilization amount of the essential oil, and forming mixed mucilage for later use;
(8) debugging the coating machine: checking whether the air pressure, the circulating water, the cooling fan, the positioning induction equipment and the like of the coating machine meet the standards or not, and ensuring the safety of preprocessing operation of the coating machine;
(9) coating: after the essential oil mixture in the step (7) is uniformly formed into mixed mucilage, coating to produce a patch coiled material, loading a cloth roll and a paper roll on a plaster coating machine, connecting a glue injection rubber tube to a coating hopper, starting glue injection, namely adding the mixed mucilage for standby in the step (7), and controlling the coating thickness to be 1.5mm and the speed to be 5 m/min; in the coating process, the coating effect is observed in real time, so that the surface of the plaster is smooth and clean, and the thickness of the plaster is uniform; sampling and measuring the thickness at regular time, wherein the sampling and measuring of the thickness are carried out for 1 time every 5 minutes, the thickness meets the process requirement, and the error does not exceed +/-5%;
(10) slitting: cutting the coiled material prepared in the coating process in the step (9) into medicine cores with proper sizes according to the technical requirements and the size standards required by the patch, picking out the medicine cores with unqualified thicknesses or other defects during cutting, and storing the qualified medicine cores for later use;
(11) synthesizing: taking a prepared non-woven fabric layer with a proper size, uncovering the non-woven fabric layer of the plaster support sheet, sticking the medicine core remained in the step (10) to the non-woven fabric layer, and then extruding to complete the synthesis of the plaster patch; wherein the non-woven fabric layer is made of mesh breathable spunlace fabric.
Example 3: a patch formula containing various essential oils for treating neck, shoulder, waist and leg pain is prepared from the following components in parts by weight: 63 parts of plaster matrix, 3 parts of safflower essential oil, 3 parts of angelica essential oil, 1 part of wintergreen essential oil, 1 part of camphor tree essential oil, 1 part of folium artemisiae argyi essential oil, 1 part of zedoary essential oil, 3 parts of scorpion, 3 parts of frankincense, 3 parts of myrrh, 3 parts of radix cyathulae, 3 parts of prepared radix aconiti agrestis, 4 parts of garden balsam stem, 3 parts of radix clematidis, 2 parts of ligusticum wallichii, 3 parts of wooly datchmanspipe herb, 4 parts of parasitic loranthus, 3 parts of lycopodium clavatum, 4 parts of cortex acanthopanacis and 2.
A preparation method of a patch containing multiple essential oils for treating neck, shoulder, waist and leg pain comprises the following steps:
(1) taking medicinal materials: 3 parts of scorpion, 3 parts of frankincense, 3 parts of myrrh, 3 parts of medicinal cyathula root, 3 parts of prepared common monkshood mother root, 3 parts of prepared kusnezoff monkshood root, 4 parts of garden balsam stem, 3 parts of clematis root, 2 parts of szechuan lovage rhizome, 3 parts of mollissima, 4 parts of Chinese taxillus twig, 3 parts of common clubmoss herb, 4 parts of cortex acanthopanacis and 2 parts of pseudo-ginseng are sequentially added into a reactor, the reactor is a hot reflux extraction and concentration tank, the traditional Chinese medicinal materials are extracted and concentrated into a traditional Chinese medicine extract by an ethanol hot;
(2) glue melting: adding 63 parts of medicinal material plaster matrix into a plaster reaction kettle, setting the temperature of the plaster reaction kettle at 170 ℃ until the plaster matrix is heated and melted into hot melt adhesive solution, and reserving for later use, wherein the plaster matrix is solid hot melt pressure sensitive adhesive plaster matrix;
(3) cooling: reducing the temperature of the plaster reaction kettle to 130 ℃, reducing the temperature of the hot melt adhesive solution to ensure the property of the medicine materials added subsequently, and cooling for later use;
(4) adding medicinal materials: adding the traditional Chinese medicine extract prepared in the step (1) into the plaster reaction kettle cooled in the step (3), keeping the temperature of the plaster reaction kettle at 130 ℃, ensuring that the stirring operation of the mixture is carried out while adding the traditional Chinese medicine extract, keeping the stirring speed of the plaster reaction kettle at 30 r/min, stirring at a constant speed for 30 min, and ensuring that the components of the traditional Chinese medicine extract and the hot melt adhesive are uniformly mixed;
(5) adding a penetrant: after the operation of step (4) is finished, taking 3 parts of penetrant, starting to add the penetrant into a plaster reaction kettle, wherein the penetrant is laurocapram, keeping the temperature of the plaster reaction kettle at 130 ℃, ensuring that the mixture is stirred while the penetrant is added, keeping the stirring speed of the plaster reaction kettle at 30 r/min, and stirring at a constant speed for 30 min, so as to ensure that the penetrant and the hot melt adhesive mixture in step (4) are uniformly mixed; laurone: it can soften cutin, enhance permeability, make medicine penetrate skin barrier, increase local or systemic blood concentration, and improve bioavailability of preparation; has transdermal promoting effect on lipophilic and hydrophilic drugs;
(6) secondary cooling: adjusting the temperature in the plaster reaction kettle to 110 ℃, ensuring the medicine property of the subsequently added essential oil, reducing the volatilization of the essential oil, and cooling for later use;
(7) adding essential oil: sequentially adding 3 parts of safflower essential oil, 3 parts of angelica essential oil, 1 part of wintergreen essential oil, 1 part of camphor tree essential oil, 1 part of folium artemisiae argyi essential oil and 1 part of curcuma zedoary essential oil into the plaster reaction kettle in the step (6), keeping the temperature at 110 ℃, accelerating the stirring operation speed while adding the essential oil components, keeping the stirring speed of the plaster reaction kettle at 50 r/min, stirring at a constant speed for 40 min, accelerating the uniform mixing of the essential oil components and the mixture in the step (6), reducing the volatilization amount of the essential oil, and forming mixed mucilage for later use;
(8) debugging the coating machine: checking whether the air pressure, the circulating water, the cooling fan, the positioning induction equipment and the like of the coating machine meet the standards or not, and ensuring the safety of preprocessing operation of the coating machine;
(9) coating: after the essential oil mixture in the step (7) is uniformly formed into mixed mucilage, coating to produce a patch coiled material, loading a cloth roll and a paper roll on a plaster coating machine, connecting a glue injection rubber tube to a coating hopper, starting glue injection, namely adding the mixed mucilage for standby in the step (7), and controlling the coating thickness to be 1.5mm and the speed to be 5 m/min; in the coating process, the coating effect is observed in real time, so that the surface of the plaster is smooth and clean, and the thickness of the plaster is uniform; sampling and measuring the thickness at regular time, wherein the sampling and measuring of the thickness are carried out for 1 time every 5 minutes, the thickness meets the process requirement, and the error does not exceed +/-5%;
(10) slitting: cutting the coiled material prepared in the coating process in the step (9) into medicine cores with proper sizes according to the technical requirements and the size standards required by the patch, picking out the medicine cores with unqualified thicknesses or other defects during cutting, and storing the qualified medicine cores for later use;
(11) synthesizing: taking a prepared non-woven fabric layer with a proper size, uncovering the non-woven fabric layer of the plaster support sheet, sticking the medicine core remained in the step (10) to the non-woven fabric layer, and then extruding to complete the synthesis of the plaster patch; wherein the non-woven fabric layer is made of mesh breathable spunlace fabric.
Example 4: a patch formula containing various essential oils for treating neck, shoulder, waist and leg pain is prepared from the following components in parts by weight: 62 parts of plaster matrix, 2 parts of safflower essential oil, 2 parts of angelica essential oil, 2 parts of wintergreen essential oil, 2 parts of camphor tree essential oil, 1 part of folium artemisiae argyi essential oil, 1 part of zedoary essential oil, 3 parts of scorpion, 3 parts of frankincense, 3 parts of myrrh, 3 parts of medicinal cyathula root, 3 parts of prepared radix aconiti, 4 parts of prepared radix aconiti agrestis, 4 parts of garden balsam stem, 3 parts of radix clematidis, 2 parts of ligusticum wallichii, 4 parts of wooly datchmanspipe herb, 4 parts of parasitic loranthus, 4 parts of lycopodium clavatum, 4 parts of cortex acanthopanacis.
A preparation method of a patch containing multiple essential oils for treating neck, shoulder, waist and leg pain comprises the following steps:
(1) taking medicinal materials: 3 parts of scorpion, 3 parts of frankincense, 3 parts of myrrh, 3 parts of medicinal cyathula root, 3 parts of prepared common monkshood mother root, 4 parts of prepared kusnezoff monkshood root, 4 parts of garden balsam stem, 3 parts of clematis root, 2 parts of szechuan lovage rhizome, 4 parts of mollissima, 4 parts of Chinese taxillus twig, 4 parts of common clubmoss herb, 4 parts of cortex acanthopanacis and 2 parts of pseudo-ginseng are sequentially added into a reactor, the reactor is a hot reflux extraction and concentration tank, the traditional Chinese medicinal materials are extracted and concentrated into a traditional Chinese medicine extract by an ethanol hot;
(2) glue melting: putting 62 parts of medicinal material plaster matrix into a plaster reaction kettle, setting the temperature of the plaster reaction kettle at 170 ℃ until the plaster matrix is heated and melted into hot melt adhesive solution, and keeping for later use, wherein the plaster matrix is solid hot melt pressure sensitive adhesive plaster matrix;
(3) cooling: reducing the temperature of the plaster reaction kettle to 130 ℃, reducing the temperature of the hot melt adhesive solution to ensure the property of the medicine materials added subsequently, and cooling for later use;
(4) adding medicinal materials: adding the traditional Chinese medicine extract prepared in the step (1) into the plaster reaction kettle cooled in the step (3), keeping the temperature of the plaster reaction kettle at 130 ℃, ensuring that the stirring operation of the mixture is carried out while adding the traditional Chinese medicine extract, keeping the stirring speed of the plaster reaction kettle at 30 r/min, stirring at a constant speed for 30 min, and ensuring that the components of the traditional Chinese medicine extract and the hot melt adhesive are uniformly mixed;
(5) adding a penetrant: after the operation of step (4) is finished, taking 2 parts of penetrant, starting to add the penetrant into a plaster reaction kettle, wherein the penetrant is laurocapram, keeping the temperature of the plaster reaction kettle at 130 ℃, ensuring that the mixture is stirred while the penetrant is added, keeping the stirring speed of the plaster reaction kettle at 30 r/min, stirring at a constant speed for 30 min, and ensuring that the penetrant and the hot melt adhesive mixture in step (4) are uniformly mixed; laurone: it can soften cutin, enhance permeability, make medicine penetrate skin barrier, increase local or systemic blood concentration, and improve bioavailability of preparation; has transdermal promoting effect on lipophilic and hydrophilic drugs;
(6) secondary cooling: adjusting the temperature in the plaster reaction kettle to 110 ℃, ensuring the medicine property of the subsequently added essential oil, reducing the volatilization of the essential oil, and cooling for later use;
(7) adding essential oil: sequentially adding 2 parts of medicinal materials including 2 parts of safflower essential oil, 2 parts of angelica essential oil, 2 parts of wintergreen essential oil, 2 parts of camphor tree essential oil, 1 part of folium artemisiae argyi essential oil and 1 part of curcuma zedoary essential oil into the plaster reaction kettle in the step (6), keeping the temperature at 110 ℃, accelerating the stirring operation speed while adding the essential oil components, keeping the stirring speed of the plaster reaction kettle at 50 r/min, stirring at a constant speed for 40 min, accelerating the uniform mixing of the essential oil components and the mixture in the step (6), reducing the volatilization amount of the essential oil, and forming mixed mucilage for later use;
(8) debugging the coating machine: checking whether the air pressure, the circulating water, the cooling fan, the positioning induction equipment and the like of the coating machine meet the standards or not, and ensuring the safety of preprocessing operation of the coating machine;
(9) coating: after the essential oil mixture in the step (7) is uniformly formed into mixed mucilage, coating to produce a patch coiled material, loading a cloth roll and a paper roll on a plaster coating machine, connecting a glue injection rubber tube to a coating hopper, starting glue injection, namely adding the mixed mucilage for standby in the step (7), and controlling the coating thickness to be 1.5mm and the speed to be 5 m/min; in the coating process, the coating effect is observed in real time, so that the surface of the plaster is smooth and clean, and the thickness of the plaster is uniform; sampling and measuring the thickness at regular time, wherein the sampling and measuring of the thickness are carried out for 1 time every 5 minutes, the thickness meets the process requirement, and the error does not exceed +/-5%;
(10) slitting: cutting the coiled material prepared in the coating process in the step (9) into medicine cores with proper sizes according to the technical requirements and the size standards required by the patch, picking out the medicine cores with unqualified thicknesses or other defects during cutting, and storing the qualified medicine cores for later use;
(11) synthesizing: taking a prepared non-woven fabric layer with a proper size, uncovering the non-woven fabric layer of the plaster support sheet, sticking the medicine core remained in the step (10) to the non-woven fabric layer, and then extruding to complete the synthesis of the plaster patch; wherein the non-woven fabric layer is made of mesh breathable spunlace fabric.
The plaster patch is an external product, has mild curative effect, achieves the purpose of treating insomnia by comprehensively conditioning without liver and kidney metabolism and direct stimulation of spleen and stomach, is simple to operate, is safe to use, has no side effect, and is easily accepted by patients.
The clinical application cases are as follows:
example 1, Mr. King, male, Henan people all over the mouth, age 52 years old, suffered from cervical spondylosis, often caused by pain and head lifting, caused by stiff neck, in severe cases caused by cervical vertebra pressure nerves and vertigo phenomenon; mr. Wang uses the plaster patch for treating neck, shoulder, waist and leg pain prepared by the patch formulation of the invention for 3 boxes, wherein 3 boxes are a course of treatment, the single-chip application time is not less than 4 hours, and the application cycle is 6 days; the patch is used early, heat sensation and burning pain are generated when the patch is applied by Mr. Wang, the neck feels relaxed, the body feels comfortable, after a treatment course is persisted, the phenomenon that cervical vertebra oppresses nerves to cause dizziness does not occur, the neck is shaken and is not as stiff as before, and the ache degree of the cervical vertebra is greatly reduced.
Example 2, a woman in the week, a woman in the country, a person in Henan province, a person in a horse, age 49 years old, lumbar disc herniation for more than 3 years, and a proper drug treatment effect is not achieved all the time by using a few muscle and bone injury patch, and the period is repeated and actually complicated; after 2 boxes of plaster patches prepared by the formula are used by a woman in the week, the using time of a single patch is kept about 8 hours, 4 days of treatment by using the plaster patch is a treatment course, the feeling of lumbar intervertebral disc is relaxed after the use of the plaster patch, the waist bending amplitude can be a little bit larger, the woman in the week continues to use 3 treatment courses, the front and the back are used for 4 treatment courses together, the lumbar intervertebral disc protrusion is obvious, the pain is avoided, the waist bending is difficult, the woman in the week can dance in a square, the woman in the week can do large-amplitude twisting actions at present, the expression of the waist pain is greatly reduced, and the plaster patch is applied, so that the plaster patch is convenient to use, simple and quick.
Example 3, a woman who is aged 48 years and has rheumatic arthritis in legs, feels cold and stabbing pain in his/her joints, and is particularly serious in rainy days in cloudy days or in cold winter; in more serious cases, numbness of limbs and stiffness of joints can last for more than ten minutes, and long-term pain makes women feel bored and very uncomfortable; the female is informed of the plaster, 1 box of the plaster is used for the first time, after the plaster is used for pasting, the leg joint has obvious burning sensation, the cold and the pricking sensation are weakened in rainy days, the female is used for pasting the plaster for one treatment course, one treatment course comprises 3 boxes and two boxes, the single piece pasting time is kept at 10 hours every day, the leg joint problem is serious, the pasting period is 10 days, one treatment course is adopted, the leg rheumatic arthritis of the female after two treatment courses is obviously improved, the pain is not caused as much as before, the phenomenon of joint stiffness cannot occur even if the female walks too much, the plaster is continuously used for the later period of the female, and the trouble of leg rheumatic pain of the female is greatly relieved.

Claims (7)

1. A patch formula containing multiple essential oils for treating neck, shoulder, waist and leg pain is characterized in that: the formula is prepared from the following components in parts by weight: 60-65 parts of plaster matrix, 1-4 parts of safflower essential oil, 1-4 parts of angelica essential oil, 1-2 parts of wintergreen essential oil, 1-2 parts of camphor tree essential oil, 1-2 parts of folium artemisiae argyi essential oil, 1-2 parts of curcuma zedoary essential oil, 2-4 parts of scorpion, 2-4 parts of frankincense, 2-4 parts of myrrh, 2-4 parts of radix cyathulae, 2-4 parts of prepared radix aconiti, 2-4 parts of prepared kusnezoff monkshood root, 3-5 parts of garden balsam stem, 2-4 parts of radix clematidis, 1-3 parts of ligusticum wallichii, 2-4 parts of wooly datchmanspipe herb, 2-4 parts of lycopodium clavatum, 2-5 parts of parasitic loranthus, 2-5 parts of cortex acanthopanacis and 1.
2. The patch formulation for the treatment of pain in the neck, shoulder, waist and legs comprising a plurality of essential oils according to claim 1, wherein: the formula is prepared from the following components in parts by weight: 63 parts of plaster matrix, 3 parts of safflower essential oil, 3 parts of angelica essential oil, 1 part of wintergreen essential oil, 1 part of camphor tree essential oil, 1 part of folium artemisiae argyi essential oil, 1 part of zedoary essential oil, 3 parts of scorpion, 3 parts of frankincense, 3 parts of myrrh, 3 parts of radix cyathulae, 3 parts of prepared radix aconiti agrestis, 4 parts of garden balsam stem, 2 parts of radix clematidis, 2 parts of ligusticum wallichii, 3 parts of wooly datchmanspipe herb, 4 parts of parasitic loranthus, 3 parts of lycopodium clavatum, 4 parts of cortex acanthopanacis and 2.
3. A preparation method of a patch containing various essential oils for treating neck, shoulder, waist and leg pain is characterized in that: the method comprises the following steps:
(1) taking medicinal materials: 3 parts of scorpion, 3 parts of frankincense, 3 parts of myrrh, 3 parts of medicinal cyathula root, 3 parts of prepared common monkshood mother root, 3 parts of prepared kusnezoff monkshood root, 4 parts of garden balsam stem, 3 parts of clematis root, 2 parts of szechuan lovage rhizome, 3 parts of mollissima, 4 parts of Chinese taxillus twig, 3 parts of common clubmoss herb, 4 parts of cortex acanthopanacis and 2 parts of pseudo-ginseng are sequentially added into a reactor, and the traditional Chinese medicinal materials are extracted and concentrated into a traditional Chinese medicine extract by an ethanol hot reflux;
(2) glue melting: adding 63 parts of medicinal material plaster matrix into a plaster reaction kettle, setting the temperature of the plaster reaction kettle at 170 ℃, heating and melting the plaster matrix into hot melt adhesive solution, and keeping for later use;
(3) cooling: reducing the temperature of the plaster reaction kettle to 130 ℃, reducing the temperature of the hot melt adhesive solution to ensure the property of the medicine materials added subsequently, and cooling for later use;
(4) adding medicinal materials: adding the traditional Chinese medicine extract prepared in the step (1) into the plaster reaction kettle cooled in the step (3), keeping the temperature of the plaster reaction kettle at 130 ℃, ensuring that the stirring operation of the mixture is carried out while adding the traditional Chinese medicine extract, keeping the stirring speed of the plaster reaction kettle at 30 r/min, stirring at a constant speed for 30 min, and ensuring that the components of the traditional Chinese medicine extract and the hot melt adhesive are uniformly mixed;
(5) adding a penetrant: after the operation of the step (4) is finished, taking 2 parts of penetrant, starting to add the penetrant, keeping the temperature of the plaster reaction kettle at 130 ℃, ensuring that the mixture is stirred while the penetrant is added, keeping the stirring speed of the plaster reaction kettle at 30 r/min, and stirring at a constant speed for 30 min, so as to ensure that the penetrant and the hot melt adhesive mixture in the step (4) are uniformly mixed;
(6) secondary cooling: adjusting the temperature in the plaster reaction kettle to 110 ℃, ensuring the medicine property of the subsequently added essential oil, reducing the volatilization of the essential oil, and cooling for later use;
(7) adding essential oil: sequentially adding 3 parts of safflower essential oil, 3 parts of angelica essential oil, 1 part of wintergreen essential oil, 1 part of camphor tree essential oil, 1 part of folium artemisiae argyi essential oil and 1 part of curcuma zedoary essential oil into the plaster reaction kettle in the step (6), keeping the temperature at 110 ℃, accelerating the stirring operation speed while adding the essential oil components, keeping the stirring speed of the plaster reaction kettle at 50 r/min, stirring at a constant speed for 40 min, accelerating the uniform mixing of the essential oil components and the mixture in the step (6), reducing the volatilization amount of the essential oil, and forming mixed mucilage for later use;
(8) debugging the coating machine: checking whether the air pressure, the circulating water, the cooling fan, the positioning induction equipment and the like of the coating machine meet the standards or not, and ensuring the safety of preprocessing operation of the coating machine;
(9) coating: after the essential oil mixture in the step (7) is uniformly formed into mixed mucilage, coating to produce a patch coiled material, loading a cloth roll and a paper roll on a plaster coating machine, connecting a glue injection rubber tube to a coating hopper, starting glue injection, namely adding the mixed mucilage for standby in the step (7), and controlling the coating thickness to be 1.5mm and the speed to be 5 m/min; in the coating process, the coating effect is observed in real time, so that the surface of the plaster is smooth and clean, and the thickness of the plaster is uniform; sampling and measuring the thickness at regular time, wherein the sampling and measuring of the thickness are carried out for 1 time every 5 minutes, the thickness meets the process requirement, and the error does not exceed +/-5%;
(10) slitting: cutting the coiled material prepared in the coating process in the step (9) into medicine cores with proper sizes according to the technical requirements and the size standards required by the patch, picking out the medicine cores with unqualified thicknesses or other defects during cutting, and storing the qualified medicine cores for later use;
(11) synthesizing: taking a prepared non-woven fabric layer with a proper size, uncovering the non-woven fabric layer of the plaster support sheet, sticking the medicine core remained in the step (10) to the non-woven fabric layer, and then extruding to complete the synthesis of the plaster patch.
4. The preparation method of the patch containing multiple essential oils for treating pain in neck, shoulders, waist and legs according to claim 3, wherein the preparation method comprises the following steps: the reactor is a hot reflux extraction concentration tank.
5. The preparation method of the patch containing multiple essential oils for treating pain in neck, shoulders, waist and legs according to claim 3, wherein the preparation method comprises the following steps: the osmotic agent is laurocapram.
6. The preparation method of the patch containing multiple essential oils for treating pain in neck, shoulders, waist and legs according to claim 3, wherein the preparation method comprises the following steps: the non-woven fabric layer is made of mesh breathable spunlace fabric.
7. The preparation method of the patch containing multiple essential oils for treating pain in neck, shoulders, waist and legs according to claim 3, wherein the preparation method comprises the following steps: the plaster substrate is a solid hot-melt pressure-sensitive adhesive plaster substrate.
CN202011064573.2A 2020-09-30 2020-09-30 Formula of patch containing multiple essential oils for treating pain in neck, shoulder, waist and leg and preparation method thereof Pending CN112057585A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109529007A (en) * 2019-01-18 2019-03-29 张振海 A kind of magistral medicines for treating pain
CN116919928A (en) * 2023-06-26 2023-10-24 云南白药集团无锡药业有限公司 Crocus sativus and notopterygium root shoulder warming patch and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1879715A (en) * 2006-05-09 2006-12-20 张燕 Chinese medicine for wax therapy of cervical spondylosis
CN101347520A (en) * 2007-07-20 2009-01-21 班倩 'Wan an' health-care paste for dispelling pain
CN105362919A (en) * 2014-08-12 2016-03-02 韦永忠 Traditional Chinese medicine preparation for external treatment of cold-dampness arthralgia
CN108186748A (en) * 2018-03-14 2018-06-22 北京吴极限进出口贸易有限公司 A kind of Recipe of plaster contained there are many essential oil quickly easing pain

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1879715A (en) * 2006-05-09 2006-12-20 张燕 Chinese medicine for wax therapy of cervical spondylosis
CN101347520A (en) * 2007-07-20 2009-01-21 班倩 'Wan an' health-care paste for dispelling pain
CN105362919A (en) * 2014-08-12 2016-03-02 韦永忠 Traditional Chinese medicine preparation for external treatment of cold-dampness arthralgia
CN108186748A (en) * 2018-03-14 2018-06-22 北京吴极限进出口贸易有限公司 A kind of Recipe of plaster contained there are many essential oil quickly easing pain

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
范高山等: ""中药热敷及拍击锻炼治老年腰肌劳损40例"", 《中原医刊》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109529007A (en) * 2019-01-18 2019-03-29 张振海 A kind of magistral medicines for treating pain
CN116919928A (en) * 2023-06-26 2023-10-24 云南白药集团无锡药业有限公司 Crocus sativus and notopterygium root shoulder warming patch and preparation method thereof
CN116919928B (en) * 2023-06-26 2024-03-19 云南白药集团无锡药业有限公司 Crocus sativus and notopterygium root shoulder warming patch and preparation method thereof

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