CN116919928B - Crocus sativus and notopterygium root shoulder warming patch and preparation method thereof - Google Patents
Crocus sativus and notopterygium root shoulder warming patch and preparation method thereof Download PDFInfo
- Publication number
- CN116919928B CN116919928B CN202310754751.1A CN202310754751A CN116919928B CN 116919928 B CN116919928 B CN 116919928B CN 202310754751 A CN202310754751 A CN 202310754751A CN 116919928 B CN116919928 B CN 116919928B
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- China
- Prior art keywords
- essential oil
- layer
- warming patch
- saffron
- shoulder warming
- Prior art date
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
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- A—HUMAN NECESSITIES
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- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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Abstract
The invention belongs to the field of health care products, and particularly discloses a saffron and notopterygium root shoulder warming patch and a preparation method thereof, wherein the saffron and notopterygium root shoulder warming patch sequentially comprises a first release film (10), a base layer (20), an infrared heating layer (30), a puncture layer (40), a medicine storage layer (50), a permeation promoting layer (60) and a second release film (80) from outside to inside; the shoulder warming patch is characterized in that wing protecting adhesive tapes (70) are arranged on two sides of the shoulder warming patch, and the essential oil bags (51) contain saffron essential oil, notopterygium essential oil, iris essential oil, citronella essential oil and hawaii fruit oil. The saffron and notopterygium root shoulder warming patch disclosed by the invention combines traditional essential oil and modern essential oil, and the transportation and the use of the shoulder warming patch are very convenient through the carefully designed puncture layer (40) and the essential oil bag (51), so that the essential oil can be efficiently led into skin, and the effects of relieving pain and improving shoulder and neck fatigue are achieved by combining a far infrared magnetic therapy function.
Description
Technical Field
The invention belongs to the field of health care products, and particularly discloses a saffron-notopterygium root shoulder warming patch and a preparation method thereof.
Background
The shoulder and neck plaster has the main effects of promoting blood circulation to remove blood stasis, relaxing muscles and tendons, relaxing muscles and relieving pain of neck and shoulder parts, wherein the shoulder and neck plaster is internally provided with traditional Chinese medicine components for promoting blood circulation to remove blood stasis, relaxing muscles and tendons, and removing obstruction in collaterals, such as lycopodium clavatum, garden balsam stem, peach kernel, safflower, mugwort leaf, baked ginger and the like, and can effectively play roles of promoting blood circulation, detumescence and relieving pain, increase local blood circulation, promote metabolism of inflammatory metabolites, increase arterial blood supply and promote recovery of local focus positions. And after venous return is increased, the inflammation is not accumulated, inflammatory edema can be obviously relieved, and the symptoms of local pain and movement disorder can be relieved. The shoulder neck patch has the effect of generating heat, and usually because the magnetic therapy reaction can generate local heat, muscle tissues can be loosened, and the peripheral blood circulation can be accelerated, so that arterial blood supply and venous reflux can be effectively promoted, local inflammation focus can be lightened, and pain is relieved.
CN201410463288.6 discloses a traditional Chinese medicine warming patch for relieving neck, shoulder, waist and leg pain and a preparation process thereof, the traditional Chinese medicine warming patch comprises a warming patch and a traditional Chinese medicine ointment laid on the warming patch, wherein the traditional Chinese medicine ointment is prepared from 12-18 parts of lycopodium clavatum, 16-24 parts of garden balsam stem, 25-35 parts of radix clematidis, 15-21 parts of raw radix aconiti, 15-21 parts of raw kusnezoff monkshood root, 9-11 parts of raw frankincense, 9-11 parts of raw myrrh, 0.8-1.2 parts of asarum, 12-18 parts of camphor, 9-11 parts of raw nux vomica and 0.8-1.2 parts of radix angelicae pubescentis by extracting with camellia oil, and then adding medicinal gelatin for mixing.
Stigma croci is a dried stigma of Crocus sativus L of Iridaceae. Introducing cultivars. There are cultivation in Beijing, shandong, zhejiang, sichuan and so on. Has effects of promoting blood circulation, removing blood stasis, cooling blood, removing toxic substance, resolving stagnation, and tranquilizing. Can be used for treating amenorrhea, puerperal stagnation, toxic heat, speckle, depression, oppression, palpitation, and mania. Notopterygium (Hansenia weberbaueriana (Fedde ex H. Wolff) Pimenov & Kljuykov) is a plant of the genus Notopterygium of the family Umbelliferae. According to the description of the outline of materia medica, the notopterygium root has the effects of relieving fever, easing pain, eliminating bacteria, resisting inflammation, resisting arrhythmia, protecting myocardial ischemia and the like, and can be used for treating symptoms such as cold fever, rheumatoid arthritis, joint muscle soreness and the like. As can be seen, the stigma croci and the notopterygium are traditional Chinese medicines in the traditional Chinese medicine, no report on how to reasonably mix the ratio of the stigma croci to the notopterygium to be used as a monarch medicine exists in the prior art, and no report on how to select other auxiliary medicines according to the traditional medicine knowledge and the modern scientific theory exists.
Disclosure of Invention
In order to solve the problems, the invention discloses a saffron and notopterygium root shoulder warming patch and a preparation method thereof, wherein saffron essential oil, notopterygium root essential oil, iris essential oil, citronella essential oil and hawaii fruit oil are selected for blending and combining to prepare an essential oil bag, and a permeation promoting layer is arranged, so that the essential oil components can be released slowly and for a long time, and can be absorbed by a human body more fully.
The technical scheme of the invention is as follows:
the crocus sativus and notopterygium root shoulder warming patch sequentially comprises a first release film, a base layer, an infrared heating layer, a puncture layer, a medicine storage layer, a permeation promoting layer and a second release film from outside to inside; wing protecting adhesive tapes are arranged on two sides of the shoulder warming patch;
the puncture layer comprises a hard substrate close to the near infrared heating layer, the bottom of the spike is arranged on the substrate, and the sharp part faces the medicine storage layer; a protective film is arranged near the medicine storage layer, and a filler is arranged between the substrate and the protective film;
a plurality of essential oil bags are arranged in the medicine storage layer;
the essential oil bag contains stigma croci essential oil, notopterygii rhizoma essential oil, iris flos essential oil, citronella essential oil and Hawaii fruit oil.
The crocus sativus is dry stigma croci of Iridaceae. There are cultivation in Beijing, shandong, zhejiang, sichuan and so on. Has effects of promoting blood circulation, removing blood stasis, cooling blood, removing toxic substance, resolving stagnation, and tranquilizing. Can be used for treating amenorrhea, puerperal stagnation, toxic heat, speckle, depression, oppression, palpitation, and mania. Notopterygium root in the scheme is recorded in the 'materia medica outline', and the Notopterygium root has the effects of relieving fever, easing pain, eliminating bacteria, resisting inflammation, resisting arrhythmia, protecting myocardial ischemia and the like, and can be used for treating symptoms such as cold fever, rheumatoid arthritis, joint muscle ache and the like. The iris essential oil is used as a perfume raw material, has the cough relieving effect, and the main component of the iris essential oil can tighten skin and has extremely high antioxidant effect and melanin generation inhibiting effect. Citronella essential oil has about 20% ketone content, which is about 7% carvone; the monoterpene alcohol accounts for a relatively high proportion, such as trans-menthol, and the like, so that the anti-bacterial and anti-inflammatory essential oil is very good. It has no taste of common mosquito-repellent essential oil, but has fresh smell. The macadamia nut oil is edible oil extracted from the macadamia nut through processing, has the effect of promoting intestinal movement, is beneficial to digestion and toxin removal, and has the effects of maintaining beauty and keeping young. Although macadamia nut oil is traditionally used as edible oil, the macadamia nut oil is creatively used for external application, and the macadamia nut oil and other essential oil are matched, so that the macadamia nut oil also has good effect of relieving muscle tension pain.
Preferably, the essential oil capsule can be made of soft capsule materials, such as gelatin, glycerol and the like.
Preferably, the protective film may be a PVC film material.
Furthermore, the crocus sativus and notopterygium root shoulder warming patch comprises the following essential oils in parts by weight:
saffron essential oil 100 parts
20-40 parts of notopterygium essential oil
15-35 parts of iris essential oil
10-20 parts of citronella essential oil
5-10 parts of macadamia nut oil.
Furthermore, the crocus sativus and notopterygium root shoulder warming patch is characterized in that the base layer is made of non-woven fabrics, and the thickness of the base layer is 3-7mm in a natural state.
Further, the infrared heating layer contains far infrared ceramic powder, neodymium iron boron magnetic sheets and vermiculite materials; the thickness of the infrared heating layer is 10-15mm.
Furthermore, according to the crocus sativus notopterygium root shoulder warming patch, the base plate and the spines are made of plastic materials, and PE plastic is preferred.
Furthermore, according to the saffron notopterygium root shoulder warming patch, the filler is soft polyurethane foam.
Further, the saffron notopterygium root shoulder warming patch is characterized in that the penetration promoting layer is a polypropylene fiber layer; the thickness is 4-6mm in natural state. The polypropylene fiber is a synthetic fiber spun from isotactic polypropylene obtained by polymerization of propylene, and preferably, ultrafine polypropylene fiber is used.
Further, the saffron notopterygium root shoulder warming patch is characterized in that the saffron essential oil is prepared by the following steps:
1) Pretreatment of raw materials: taking dry stigma of crocus sativus, cleaning with clear water, drying in a vacuum drying oven until the water content is 8-12%, taking out, grinding for 15-30min with a pulverizer, and sieving with a 200-400 mesh sieve; obtaining powder; adding into an enzymolysis tank, adding deionized water to keep the solid-liquid ratio at 500-700g/L, and heating at 75-95deg.C for 4-6 hr;
2) First enzyme treatment: cooling to 30-40 ℃, and adding crashing enzyme and educing enzyme R-10 into an enzymolysis tank for primary enzyme treatment to obtain primary enzyme treatment liquid;
3) And (3) water extraction treatment: adding the first enzyme treatment solution obtained in the step into a stainless steel extraction tank, opening a jacket of the extraction tank to heat steam, and preserving heat at 121-130 ℃ for 4-8min; closing steam, opening an extraction tank stirrer, opening extraction tank jacket cooling water, reducing the temperature of materials in the tank to 85-95 ℃, preserving heat, stirring and extracting for 2-4h, then opening the extraction tank jacket cooling water to cool the materials to 20-30 ℃, then opening extraction tank jacket freezing brine to cool the materials to 4-8 ℃, preserving heat and standing for 1-3h, and preparing to obtain water extraction treatment liquid;
4) And (3) filtering: filtering the water extraction treatment solution with 200 mesh gauze filter bag, and collecting filtrate;
5) Second enzyme treatment: adding chitinase and glucosidase into an enzymolysis tank, and performing secondary enzyme treatment on the filtrate obtained in the step 4) to obtain secondary enzyme treatment liquid;
6) Extracting essential oil: extracting essential oil from the second enzyme treatment liquid by reflux distillation extraction method, wherein the temperature in the reflux distillation extraction method is lower than 70 ℃.
Further, the concentration of the crashing enzyme in the step 2) is 2-4x10, and the concentration of the saffron-notopterygium root shoulder warming patch is 2-4x10 2 U/mL; the concentration of the educt enzyme R-10 is 1.5-2.5x10 3 U/mL; the enzyme treatment time is 8-16h;
the chitinase concentration in step 5) is 2.5-5x10 3 U/mL, concentration of glucosidase 1-4x10 2 U/mL, enzyme treatment time is 4-8h.
Further, the preparation method of the crocus sativus notopterygium root shoulder warming patch is characterized by comprising the following steps of:
a) Preparing essential oil into an essential oil bag with a flexible shell according to the prior art, and further preparing into a medicine storage layer; preferably, the shell of the essential oil bag can be made of materials mainly including gelatin;
b) Sequentially sewing or bonding the base layer, the infrared heating layer, the puncture layer, the medicine storage layer and the permeation promoting layer;
c) Sewing wing-protecting adhesive tapes on two sides of the shoulder warming patch;
d) The first release film is attached after the adhesive is coated on the outer side of the base layer, and the second release film is attached after the adhesive is coated on the outer side of the permeation promoting layer.
Compared with the prior art, the invention has the following beneficial effects:
in the prior art, the combination of saffron essential oil, notopterygium essential oil, iris essential oil, citronella essential oil and hawaii fruit oil is not reported. And macadamia nut oil is generally used only as an edible oil. The creative discovery of the invention shows that the effects of relieving pain, relaxing tendons, activating blood circulation and relieving muscle stiffness of the saffron essential oil and the notopterygium essential oil can be greatly exerted after the iris essential oil, the citronella essential oil and the hawaii fruit oil are added.
On the other hand, the invention also discloses a preparation method of the saffron essential oil, which utilizes a two-step enzymolysis method to furthest reserve and purify effective substances in traditional Chinese medicinal materials, and has relatively short preparation flow and low requirements on equipment.
Furthermore, other essential oils in the invention can be easily obtained commercially from the market, and the preparation cost is low.
Furthermore, the invention discloses the saffron notopterygium root shoulder warming patch containing the essential oil, which is carefully designed with
The puncture layer and the medicine storage layer are convenient to transport and use, when the multifunctional shoulder warming patch is used, the base plate in the puncture layer is only pressed down with force, the tip is punctured to break through the protective film, the essential oil bag is punctured, the essential oil flows out, the far infrared magnetic therapy heating and the permeation promoting layer are combined, the essential oil can be slowly released for a long time, and the long-acting shoulder warming patch can play a role of long-acting shoulder warming patch health care in cooperation with the far infrared heating magnetic therapy.
Drawings
FIG. 1 is a schematic diagram of a crocus sativus and notopterygium root shoulder warming patch disclosed by the invention;
FIG. 2 is a schematic structural diagram of a Notopterygium incisum shoulder warming patch disclosed in comparative example 5
FIG. 3 is a graph showing the slow release effect test of the essential oil of the crocus sativus and Notopterygium root shoulder warming patch in test example 1;
FIG. 4 is a comparison of improvement rates of muscle stiffness in test example 2;
FIG. 5 is a comparison of the improvement rate of shoulder pain in test example 2;
FIG. 6 is a comparison of headache improvement rates in test example 2;
wherein: the first release film 10, the base layer 20, the infrared heating layer 30, the puncture layer 40, the substrate 41, the spike 42, the protective film 43, the medicine storage layer 50, the essential oil bag 51, the permeation promoting layer 60, the wing tape 70 and the second release film 80.
Detailed Description
The crocus sativus notopterygium shoulder warming patch shown in fig. 1 sequentially comprises a first release film 10, a base layer 20, an infrared heating layer 30, a puncture layer 40, a medicine storage layer 50, a permeation promoting layer 60 and a second release film 80 from outside to inside; wing protecting adhesive tapes 70 are arranged on two sides of the shoulder warming patch;
the puncture layer 40 comprises a hard substrate 41 close to the near infrared heating layer 30 and a spike on the substrate 41, the bottom of the spike 42 is arranged on the substrate 41, and the sharp part faces the medicine storage layer 50; a protective film 43 is arranged near the medicine storage layer 50, and a filler is arranged between the substrate 41 and the protective film 43;
a plurality of essential oil bags 51 are arranged in the medicine storage layer 50;
the essential oil bag 51 contains stigma croci essential oil, notopterygii rhizoma essential oil, iris flos essential oil, citronella essential oil and Hawaii fruit oil.
Each essential oil bag 51 contains the following essential oils in parts by weight:
saffron essential oil 100 parts
20-40 parts of notopterygium essential oil
15-35 parts of iris essential oil
10-20 parts of citronella essential oil
5-10 parts of macadamia nut oil;
the base layer 20 is made of non-woven fabric, and has a thickness of 3-7mm in a natural state;
the infrared heating layer 30 contains far infrared ceramic powder, neodymium iron boron magnetic sheets and vermiculite materials; the thickness of the infrared heating layer 30 is 10-15mm;
the base plate 41 and the spike 42 are made of plastic, preferably PE plastic;
the filler is soft polyurethane foam;
the permeation enhancer layer 60 is a polypropylene fiber layer; the thickness is 4-6mm in natural state;
the saffron essential oil is prepared by the following steps:
1) Pretreatment of raw materials: taking dry stigma of crocus sativus, cleaning with clear water, drying in a vacuum drying oven until the water content is 8-12%, taking out, grinding for 15-30min with a pulverizer, and sieving with a 200-400 mesh sieve; obtaining powder; adding into an enzymolysis tank, adding deionized water to keep the solid-liquid ratio at 500-700g/L, and heating at 75-95deg.C for 4-6 hr;
2) First enzyme treatment: cooling to 30-40 ℃, and adding crashing enzyme and educing enzyme R-10 into an enzymolysis tank for primary enzyme treatment to obtain primary enzyme treatment liquid;
3) And (3) water extraction treatment: adding the first enzyme treatment solution obtained in the step 2 into a stainless steel extraction tank, opening a jacket of the extraction tank to heat steam, and preserving heat at 121-130 ℃ for 4-8min; closing steam, opening an extraction tank stirrer, opening extraction tank jacket cooling water, reducing the temperature of materials in the tank to 85-95 ℃, preserving heat, stirring and extracting for 2-4h, then opening the extraction tank jacket cooling water to cool the materials to 20-30 ℃, then opening extraction tank jacket freezing brine to cool the materials to 4-8 ℃, preserving heat and standing for 1-3h, and preparing to obtain water extraction treatment liquid;
4) And (3) filtering: filtering the water extraction treatment solution with 200 mesh gauze filter bag, and collecting filtrate;
5) Second enzyme treatment: adding chitinase and glucosidase into an enzymolysis tank, and performing secondary enzyme treatment on the filtrate obtained in the step 4 to obtain secondary enzyme treatment liquid;
6) Extracting essential oil: extracting essential oil from the second enzyme treatment liquid by reflux distillation extraction method, wherein the temperature in the reflux distillation extraction method is lower than 70 ℃.
The concentration of the crashase in the step 2 is 2-4x10 2 U/mL; the concentration of the educt enzyme R-10 is 1.5-2.5x10 3 U/mL; the enzyme treatment time is 8-16h;
the chitinase concentration in step 5 is 2.5-5x10 3 U/mL, concentration of glucosidase 1-4x10 2 U/mL, enzyme treatment time is 4-8h.
The preparation method of the crocus sativus and notopterygium root shoulder warming patch is characterized by comprising the following steps of:
a, preparing essential oil into an essential oil bag 51 with a flexible shell according to the prior art, and further preparing into a medicine storage layer 50;
b, sequentially sewing or bonding the base layer 20, the infrared heating layer 30, the puncture layer 40, the medicine storage layer 50 and the permeation promoting layer 60;
c sewing wing-protecting adhesive tapes 70 on two sides of the shoulder warming patch;
d the first release film 10 is attached after the adhesive is coated on the outside of the base layer 20, and the second release film 80 is attached after the adhesive is coated on the outside of the permeation enhancing layer 60.
The following description of the embodiments of the present invention will be made clearly and completely, and it is apparent that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The reagents or instruments used in the examples of the present invention were not manufacturer-identified and were conventional reagent products commercially available.
The commercial shoulder warming patch in the comparative example is: the primordial qi is supplied to the people for warming and applying the citrus and bitter orange flower essential oil hot compress to the shoulder.
Notopterygium essential oil is purchased from Wuhan Bei Leshe biological medicine technology Co.Ltd with 99 percent of content
Iris essential oil is purchased from Siam Huilin Biotechnology Co.Ltd CAS 8002-73-1
Citronella essential oil was purchased from the western security tandem biotechnology company limited
Hawaii oil was purchased from Siam Huilin Biotechnology Inc.
Example 1
The crocus sativus notopterygium shoulder warming patch shown in fig. 1 sequentially comprises a first release film 10, a base layer 20, an infrared heating layer 30, a puncture layer 40, a medicine storage layer 50, a permeation promoting layer 60 and a second release film 80 from outside to inside; wing protecting adhesive tapes 70 are arranged on two sides of the shoulder warming patch;
the puncture layer 40 comprises a hard substrate 41 close to the near infrared heating layer 30 and a spike on the substrate 41, the bottom of the spike 42 is arranged on the substrate 41, and the sharp part faces the medicine storage layer 50; a protective film 43 is arranged near the medicine storage layer 50, and a filler is arranged between the substrate 41 and the protective film 43;
a plurality of essential oil bags 51 are arranged in the medicine storage layer 50;
the essential oil bag 51 contains stigma croci essential oil, notopterygii rhizoma essential oil, iris flos essential oil, citronella essential oil and Hawaii fruit oil.
Each essential oil bag 51 contains the following essential oils in parts by weight:
saffron essential oil 100 parts
Notopterygium essential oil 20 parts
15 parts of iris essential oil
Citronella essential oil 10 parts
5 parts of macadamia nut oil;
the base layer 20 is made of non-woven fabric, and has a thickness of 5mm in a natural state;
the infrared heating layer 30 contains far infrared ceramic powder, neodymium iron boron magnetic sheets and vermiculite materials; the thickness of the infrared heating layer 30 is 12mm;
the base plate 41 and the spines 42 are PE plastic;
the filler is soft polyurethane foam;
the permeation enhancer layer 60 is a polypropylene fiber layer; the thickness is 5mm in a natural state;
the saffron essential oil is prepared by the following steps:
1) Pretreatment of raw materials: taking dry stigma of crocus sativus, cleaning with clear water, drying in a vacuum drying oven until the water content is 8-12%, taking out, grinding for 15-30min with a pulverizer, and sieving with a 200-400 mesh sieve; obtaining powder; adding into an enzymolysis tank, adding deionized water to keep the solid-liquid ratio at 500-700g/L, and heating at 75-95deg.C for 4-6 hr;
2) First enzyme treatment: cooling to 30-40 ℃, and adding crashing enzyme and educing enzyme R-10 into an enzymolysis tank for primary enzyme treatment to obtain primary enzyme treatment liquid;
3) And (3) water extraction treatment: adding the first enzyme treatment solution obtained in the step 2 into a stainless steel extraction tank, opening a jacket of the extraction tank to heat steam, and preserving heat at 121-130 ℃ for 4-8min; closing steam, opening an extraction tank stirrer, opening extraction tank jacket cooling water, reducing the temperature of materials in the tank to 85-95 ℃, preserving heat, stirring and extracting for 2-4h, then opening the extraction tank jacket cooling water to cool the materials to 20-30 ℃, then opening extraction tank jacket freezing brine to cool the materials to 4-8 ℃, preserving heat and standing for 1-3h, and preparing to obtain water extraction treatment liquid;
4) And (3) filtering: filtering the water extraction treatment solution with 200 mesh gauze filter bag, and collecting filtrate;
5) Second enzyme treatment: adding chitinase and glucosidase into an enzymolysis tank, and performing secondary enzyme treatment on the filtrate obtained in the step 4 to obtain secondary enzyme treatment liquid;
6) Extracting essential oil: extracting essential oil from the second enzyme treatment liquid by reflux distillation extraction method, wherein the temperature in the reflux distillation extraction method is lower than 70 ℃.
The concentration of the crashase in the step 2 is 2-4x10 2 U/mL; the concentration of the educt enzyme R-10 is 1.5-2.5x10 3 U/mL; the enzyme treatment time is 8-16h;
the chitinase concentration in step 5 is 2.5-5x10 3 U/mL, concentration of glucosidase 1-4x10 2 U/mL, enzyme treatment time is 4-8h.
The preparation method of the crocus sativus and notopterygium root shoulder warming patch is characterized by comprising the following steps of:
a, preparing essential oil into an essential oil bag 51 with a flexible shell according to the prior art, and further preparing into a medicine storage layer 50;
b, sequentially sewing or bonding the base layer 20, the infrared heating layer 30, the puncture layer 40, the medicine storage layer 50 and the permeation promoting layer 60;
c sewing wing-protecting adhesive tapes 70 on two sides of the shoulder warming patch;
d the first release film 10 is attached after the adhesive is coated on the outside of the base layer 20, and the second release film 80 is attached after the adhesive is coated on the outside of the permeation enhancing layer 60.
Example 2
The crocus sativus notopterygium shoulder warming patch shown in fig. 1 sequentially comprises a first release film 10, a base layer 20, an infrared heating layer 30, a puncture layer 40, a medicine storage layer 50, a permeation promoting layer 60 and a second release film 80 from outside to inside; wing protecting adhesive tapes 70 are arranged on two sides of the shoulder warming patch;
the puncture layer 40 comprises a hard substrate 41 close to the near infrared heating layer 30 and a spike on the substrate 41, the bottom of the spike 42 is arranged on the substrate 41, and the sharp part faces the medicine storage layer 50; a protective film 43 is arranged near the medicine storage layer 50, and a filler is arranged between the substrate 41 and the protective film 43;
a plurality of essential oil bags 51 are arranged in the medicine storage layer 50;
the essential oil bag 51 contains stigma croci essential oil, notopterygii rhizoma essential oil, iris flos essential oil, citronella essential oil and Hawaii fruit oil.
Each essential oil bag 51 contains the following essential oils in parts by weight:
saffron essential oil 100 parts
Notopterygium essential oil 30 parts
25 parts of iris essential oil
Citronella essential oil 15 parts
8 parts of macadamia nut oil;
the base layer 20 is made of non-woven fabric, and has a thickness of 5mm in a natural state;
the infrared heating layer 30 contains far infrared ceramic powder, neodymium iron boron magnetic sheets and vermiculite materials; the thickness of the infrared heating layer 30 is 112mm;
the base plate 41 and the spines 42 are PE plastic;
the filler is soft polyurethane foam;
the permeation enhancer layer 60 is a polypropylene fiber layer; the thickness is 5mm in a natural state;
the saffron essential oil is prepared by the following steps:
1) Pretreatment of raw materials: taking dry stigma of crocus sativus, cleaning with clear water, drying in a vacuum drying oven until the water content is 8-12%, taking out, grinding for 15-30min with a pulverizer, and sieving with a 200-400 mesh sieve; obtaining powder; adding into an enzymolysis tank, adding deionized water to keep the solid-liquid ratio at 500-700g/L, and heating at 75-95deg.C for 4-6 hr;
2) First enzyme treatment: cooling to 30-40 ℃, and adding crashing enzyme and educing enzyme R-10 into an enzymolysis tank for primary enzyme treatment to obtain primary enzyme treatment liquid;
3) And (3) water extraction treatment: adding the first enzyme treatment solution obtained in the step 2 into a stainless steel extraction tank, opening a jacket of the extraction tank to heat steam, and preserving heat at 121-130 ℃ for 4-8min; closing steam, opening an extraction tank stirrer, opening extraction tank jacket cooling water, reducing the temperature of materials in the tank to 85-95 ℃, preserving heat, stirring and extracting for 2-4h, then opening the extraction tank jacket cooling water to cool the materials to 20-30 ℃, then opening extraction tank jacket freezing brine to cool the materials to 4-8 ℃, preserving heat and standing for 1-3h, and preparing to obtain water extraction treatment liquid;
4) And (3) filtering: filtering the water extraction treatment solution with 200 mesh gauze filter bag, and collecting filtrate;
5) Second enzyme treatment: adding chitinase and glucosidase into an enzymolysis tank, and performing secondary enzyme treatment on the filtrate obtained in the step 4 to obtain secondary enzyme treatment liquid;
6) Extracting essential oil: extracting essential oil from the second enzyme treatment liquid by reflux distillation extraction method, wherein the temperature in the reflux distillation extraction method is lower than 70 ℃.
The concentration of the crashase in the step 2 is 2-4x10 2 U/mL; the concentration of the educt enzyme R-10 is 1.5-2.5x10 3 U/mL; the enzyme treatment time is 8-16h;
the chitinase concentration in step 5 is 2.5-5x10 3 U/mL, concentration of glucosidase 1-4x10 2 U/mL, enzyme treatment time is 4-8h.
The preparation method of the crocus sativus and notopterygium root shoulder warming patch is characterized by comprising the following steps of:
a, preparing essential oil into an essential oil bag 51 with a flexible shell according to the prior art, and further preparing into a medicine storage layer 50;
b, sequentially sewing or bonding the base layer 20, the infrared heating layer 30, the puncture layer 40, the medicine storage layer 50 and the permeation promoting layer 60;
c sewing wing-protecting adhesive tapes 70 on two sides of the shoulder warming patch;
d the first release film 10 is attached after the adhesive is coated on the outside of the base layer 20, and the second release film 80 is attached after the adhesive is coated on the outside of the permeation enhancing layer 60.
Example 3
The crocus sativus notopterygium shoulder warming patch shown in fig. 1 sequentially comprises a first release film 10, a base layer 20, an infrared heating layer 30, a puncture layer 40, a medicine storage layer 50, a permeation promoting layer 60 and a second release film 80 from outside to inside; wing protecting adhesive tapes 70 are arranged on two sides of the shoulder warming patch;
the puncture layer 40 comprises a hard substrate 41 close to the near infrared heating layer 30 and a spike on the substrate 41, the bottom of the spike 42 is arranged on the substrate 41, and the sharp part faces the medicine storage layer 50; a protective film 43 is arranged near the medicine storage layer 50, and a filler is arranged between the substrate 41 and the protective film 43;
a plurality of essential oil bags 51 are arranged in the medicine storage layer 50;
the essential oil bag 51 contains stigma croci essential oil, notopterygii rhizoma essential oil, iris flos essential oil, citronella essential oil and Hawaii fruit oil.
Each essential oil bag 51 contains the following essential oils in parts by weight:
saffron essential oil 100 parts
Notopterygium essential oil 40 parts
35 parts of iris essential oil
Citronella essential oil 20 parts
10 parts of macadamia nut oil;
the base layer 20 is made of non-woven fabric, and has a thickness of 5mm in a natural state;
the infrared heating layer 30 contains far infrared ceramic powder, neodymium iron boron magnetic sheets and vermiculite materials; the thickness of the infrared heating layer 30 is 12mm;
the base plate 41 and the spines 42 are PE plastic;
the filler is soft polyurethane foam;
the permeation enhancer layer 60 is a polypropylene fiber layer; the thickness is 5mm in a natural state;
the saffron essential oil is prepared by the following steps:
1) Pretreatment of raw materials: taking dry stigma of crocus sativus, cleaning with clear water, drying in a vacuum drying oven until the water content is 8-12%, taking out, grinding for 15-30min with a pulverizer, and sieving with a 200-400 mesh sieve; obtaining powder; adding into an enzymolysis tank, adding deionized water to keep the solid-liquid ratio at 500-700g/L, and heating at 75-95deg.C for 4-6 hr;
2) First enzyme treatment: cooling to 30-40 ℃, and adding crashing enzyme and educing enzyme R-10 into an enzymolysis tank for primary enzyme treatment to obtain primary enzyme treatment liquid;
3) And (3) water extraction treatment: adding the first enzyme treatment solution obtained in the step 2 into a stainless steel extraction tank, opening a jacket of the extraction tank to heat steam, and preserving heat at 121-130 ℃ for 4-8min; closing steam, opening an extraction tank stirrer, opening extraction tank jacket cooling water, reducing the temperature of materials in the tank to 85-95 ℃, preserving heat, stirring and extracting for 2-4h, then opening the extraction tank jacket cooling water to cool the materials to 20-30 ℃, then opening extraction tank jacket freezing brine to cool the materials to 4-8 ℃, preserving heat and standing for 1-3h, and preparing to obtain water extraction treatment liquid;
4) And (3) filtering: filtering the water extraction treatment solution with 200 mesh gauze filter bag, and collecting filtrate;
5) Second enzyme treatment: adding chitinase and glucosidase into an enzymolysis tank, and performing secondary enzyme treatment on the filtrate obtained in the step 4 to obtain secondary enzyme treatment liquid;
6) Extracting essential oil: extracting essential oil from the second enzyme treatment liquid by reflux distillation extraction method, wherein the temperature in the reflux distillation extraction method is lower than 70 ℃.
The concentration of the crashase in the step 2 is 2-4x10 2 U/mL; the concentration of the educt enzyme R-10 is 1.5-2.5x10 3 U/mL; the enzyme treatment time is 8-16h;
the chitinase concentration in step 5 is 2.5-5x10 3 U/mL, concentration of glucosidase 1-4x10 2 U/mL, enzyme treatment time is 4-8h.
The preparation method of the crocus sativus and notopterygium root shoulder warming patch is characterized by comprising the following steps of:
a, preparing essential oil into an essential oil bag 51 with a flexible shell according to the prior art, and further preparing into a medicine storage layer 50;
b, sequentially sewing or bonding the base layer 20, the infrared heating layer 30, the puncture layer 40, the medicine storage layer 50 and the permeation promoting layer 60;
c sewing wing-protecting adhesive tapes 70 on two sides of the shoulder warming patch;
d the first release film 10 is attached after the adhesive is coated on the outside of the base layer 20, and the second release film 80 is attached after the adhesive is coated on the outside of the permeation enhancing layer 60.
Comparative example 1
Each essential oil bag 51 contains the following essential oils in parts by weight:
saffron essential oil 100 parts
Notopterygium essential oil 30 parts
Does not contain
25 parts of iris essential oil
Citronella essential oil 15 parts
8 parts of macadamia nut oil;
the remainder was the same as in example 2.
Comparative example 2
Each essential oil bag 51 contains the following essential oils in parts by weight:
saffron essential oil 100 parts
25 parts of iris essential oil
Citronella essential oil 15 parts
Hawaii fruit oil 8 parts
Does not contain
Notopterygium essential oil 30 parts
The remainder was the same as in example 2.
Comparative example 3
Each essential oil bag 51 contains the following essential oils in parts by weight:
saffron essential oil 100 parts
Notopterygium essential oil 30 parts
25 parts of iris essential oil
Citronella essential oil 15 parts
Does not contain
8 parts of macadamia nut oil;
the remainder was the same as in example 2.
Comparative example 4
The saffron essential oil is prepared by the following steps:
1) Pretreatment of raw materials: taking dry stigma of crocus sativus, cleaning with clear water, drying in a vacuum drying oven until the water content is 8-12%, taking out, grinding for 15-30min with a pulverizer, and sieving with a 200-400 mesh sieve; obtaining powder; adding into an enzymolysis tank, adding deionized water to keep the solid-liquid ratio at 500-700g/L, and heating at 75-95deg.C for 4-6 hr;
2) First enzyme treatment: cooling to 30-40 ℃, and adding crashing enzyme and educing enzyme R-10 into an enzymolysis tank for primary enzyme treatment to obtain primary enzyme treatment liquid;
3) And (3) water extraction treatment: adding the first enzyme treatment solution obtained in the step 2 into a stainless steel extraction tank, opening a jacket of the extraction tank to heat steam, and preserving heat at 121-130 ℃ for 4-8min; closing steam, opening an extraction tank stirrer, opening extraction tank jacket cooling water, reducing the temperature of materials in the tank to 85-95 ℃, preserving heat, stirring and extracting for 2-4h, then opening the extraction tank jacket cooling water to cool the materials to 20-30 ℃, then opening extraction tank jacket freezing brine to cool the materials to 4-8 ℃, preserving heat and standing for 1-3h, and preparing to obtain water extraction treatment liquid;
4) And (3) filtering: filtering the water extraction treatment solution with 200 mesh gauze filter bag, and collecting filtrate;
5) Extracting essential oil: extracting essential oil from the filtrate by reflux distillation extraction method, wherein the temperature in the reflux distillation extraction method is lower than 70 ℃.
Does not contain a secondary enzymolysis step, and the rest is the same as example 2
Comparative example 5
The crocus sativus notopterygium shoulder warming patch shown in fig. 2 sequentially comprises a first release film 10, a base layer 20, an infrared heating layer 30, a puncture layer 40, a medicine storage layer 50 and a second release film 80 from outside to inside; wing protecting adhesive tapes 70 are arranged on two sides of the shoulder warming patch;
the puncture layer 40 comprises a hard substrate 41 close to the near infrared heating layer 30 and a spike on the substrate 41, the bottom of the spike 42 is arranged on the substrate 41, and the sharp part faces the medicine storage layer 50; a protective film 43 is arranged near the medicine storage layer 50, and a filler is arranged between the substrate 41 and the protective film 43;
a plurality of essential oil bags 51 are arranged in the medicine storage layer 50;
the essential oil bag 51 contains stigma croci essential oil, notopterygii rhizoma essential oil, iris flos essential oil, citronella essential oil and Hawaii fruit oil.
The permeation enhancer layer 60 was not contained, and the other was the same as in example 2.
Test example 1
Shoulder warming patch essential oil release test
The test of example 2 and comparative example 5 was conducted, the base plate 41 was pressed, the drug storage layer 50 was pierced, the first release film 10 and the second release film 80 were peeled off by applying a warm shoulder patch, and cut into a size of 3cm in diameter, and the cut was inverted and pressed against a water-absorbing and oil-absorbing toilet paper, and the toilet paper was replaced with a new one every 1 hour, and the amount of permeation of the essential oil was visually observed for 1 to 8 hours, 10 parallel groups were conducted for each example, and the average diameter of the oil spots was taken.
Table 1 shoulder warming patch essential oil slow release effect test
As can be seen from the data of table 1 and fig. 3, the shoulder warming patch of the present invention provided with the permeation promoting layer 60 can uniformly exude essential oil within 1 to 8 hours, and can maintain a long effect; in comparative example 5, in which the permeation enhancer layer 60 was not provided, a large amount of essential oil was oozed out at 1 st hour, and little essential oil was left after 5 hours, which resulted in short duration of action of the shoulder warming patch of comparative example 5, non-linearity of release of essential oil, frequent replacement of a new shoulder warming patch was required, and poor experience.
Test example 2
Clinical test of shoulder warming patch
Volunteers were randomly extracted and randomly divided into 9 groups, and 50 patients in each group were subjected to treatment effect statistics, and after the patients were all suffering from shoulder and neck discomfort and postencephalalgia due to sedentary sitting, the patients were respectively examined by questionnaires for relieving the muscle stiffness, shoulder pain and headache (improvement rate%) after 1 course of treatment of each group of patients with the shoulder warming patch (6 x8cm, containing 6g of essential oil) according to the present invention, and the answers were (1) or (0) improvement.
The application method of the invention comprises the following steps: is applied to the left and right shoulders for 8 hours a day, and 7 days is a treatment course.
Table 2 symptom improvement rate:
| muscle stiffness modificationGood rate% | Shoulder pain improvement rate% | Headache improvement rate% | |
| Example 1 | 94 | 94 | 92 |
| Example 2 | 96 | 96 | 90 |
| Example 3 | 92 | 94 | 88 |
| Comparative example 1 | 72 | 66 | 58 |
| Comparative example 2 | 68 | 70 | 62 |
| Comparative example 3 | 74 | 76 | 68 |
| Comparative example 4 | 80 | 82 | 76 |
| Comparative example 5 | 66 | 58 | 60 |
| Commercially available shoulder warming plaster | 60 | 62 | 54 |
As can be seen from the data in table 2 and fig. 4-6, the present invention has three innovative points, namely, 1: comparison of examples 1-3 with comparative example 2 with a combination of saffron and notopterygium essential oils; 2: secondary enzymolysis was used in the preparation of essential oils, see examples 1-3 and comparison of comparative example 4; 3: the effect of using iris essential oil, citronella essential oil, hawaii essential oil as auxiliary essential oil, see examples 1-3 for comparison with comparative examples 1 and 3; 4 providing an essential oil-introducing slow release layer, see examples 1-3 and comparison of comparative example 5.
The following conclusions can be drawn from the examples and test cases: after the iris essential oil, the citronella essential oil and the hawaii fruit oil are added, the effects of relieving pain, relaxing tendons, activating blood and relieving muscle stiffness of the saffron essential oil and the notopterygium root essential oil can be greatly exerted.
The foregoing is a description of only a limited number of preferred embodiments of the invention, which are described in greater detail and are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention.
Claims (9)
1. The saffron notopterygium root shoulder warming patch is characterized by sequentially comprising a first release film (10), a base layer (20), an infrared heating layer (30), a puncture layer (40), a medicine storage layer (50), a permeation promoting layer (60) and a second release film (80) from outside to inside; both sides of the shoulder warming patch are also provided with wing protecting adhesive tapes (70);
the puncture layer (40) comprises a hard substrate (41) close to the near infrared heating layer (30) and a spike on the substrate (41), the bottom of the spike (42) is arranged on the substrate (41), and the sharp part faces the medicine storage layer (50); a protective film (43) is arranged near the medicine storage layer (50), and a filler is arranged between the substrate (41) and the protective film (43);
a plurality of essential oil bags (51) are arranged in the medicine storage layer (50);
the essential oil bag (51) contains the following essential oils in parts by weight:
saffron essential oil 100 parts
20-40 parts of notopterygium essential oil
15-35 parts of iris essential oil
10-20 parts of citronella essential oil
5-10 parts of macadamia nut oil.
2. The saffron notopterygium root shoulder warming patch according to claim 1, wherein the base layer (20) is made of non-woven fabric, and has a thickness of 3-7mm in a natural state.
3. The saffron notopterygium root shoulder warming patch according to claim 1, wherein the infrared heating layer (30) contains far infrared ceramic powder, neodymium iron boron magnetic sheets and vermiculite materials; the thickness of the infrared heating layer (30) is 10-15mm.
4. The saffron notopterygium root shoulder warming patch according to claim 1, wherein the base plate (41) and the spike (42) are made of PE plastic materials.
5. The saffron notopterygium root shoulder warming patch of claim 1, wherein the filler is soft polyurethane foam.
6. The saffron notopterygium root shoulder warming patch according to claim 1, wherein said penetration promoting layer (60) is a polypropylene fiber layer; the thickness is 4-6mm in natural state.
7. The saffron notopterygium root shoulder warming patch of claim 1, wherein said saffron essential oil is prepared by the steps of:
1) Pretreatment of raw materials: taking dry stigma of crocus sativus, cleaning with clear water, drying in a vacuum drying oven until the water content is 8-12%, taking out, grinding for 15-30min with a pulverizer, and sieving with a 200-400 mesh sieve; obtaining powder; adding into an enzymolysis tank, adding deionized water to keep the solid-liquid ratio at 500-700g/L, and heating at 75-95deg.C for 4-6 hr;
2) First enzyme treatment: cooling to 30-40 ℃, and adding crashing enzyme and educing enzyme R-10 into an enzymolysis tank for primary enzyme treatment to obtain primary enzyme treatment liquid;
3) And (3) water extraction treatment: adding the first enzyme treatment solution obtained in the step (2) into a stainless steel extraction tank, opening a jacket of the extraction tank to heat steam, and preserving heat at 121-130 ℃ for 4-8min; closing steam, opening an extraction tank stirrer, opening extraction tank jacket cooling water, reducing the temperature of materials in the tank to 85-95 ℃, preserving heat, stirring and extracting for 2-4h, then opening the extraction tank jacket cooling water to cool the materials to 20-30 ℃, then opening extraction tank jacket freezing brine to cool the materials to 4-8 ℃, preserving heat and standing for 1-3h, and preparing to obtain water extraction treatment liquid;
4) And (3) filtering: filtering the water extraction treatment solution with 200 mesh gauze filter bag, and collecting filtrate;
5) Second enzyme treatment: adding chitinase and glucosidase into an enzymolysis tank, and performing secondary enzyme treatment on the filtrate obtained in the step 4) to obtain secondary enzyme treatment liquid;
6) Extracting essential oil: extracting essential oil from the second enzyme treatment liquid by reflux distillation extraction method, wherein the temperature in the reflux distillation extraction method is lower than 70 ℃.
8. The saffron notopterygium root shoulder warming patch according to claim 7, wherein,
the concentration of the crashing enzyme in the step 2) is 2-4x10 2 U/mL; the concentration of the educt enzyme R-10 is 1.5-2.5x10 3 U/mL; the enzyme treatment time is 8-16h;
the chitinase concentration in step 5) is 2.5-5x10 3 U/mL, concentration of glucosidase 1-4x10 2 U/mL, enzyme treatment time is 4-8h.
9. The method for preparing the crocus sativus and notopterygium root shoulder warming patch according to any one of claims 1 to 8, comprising the following steps:
a) Preparing essential oil into an essential oil bag (51) with a flexible shell according to the prior art, and further preparing into a medicine storage layer (50);
b) Sequentially sewing or bonding a base layer (20), an infrared heating layer (30), a puncture layer (40), a medicine storage layer (50) and a permeation promoting layer (60);
c) Wing-protecting adhesive tapes (70) are sewn on the two sides of the shoulder warming patch;
d) The first release film (10) is attached after the adhesive is coated on the outer side of the base layer (20), and the second release film (80) is attached after the adhesive is coated on the outer side of the permeation promoting layer (60).
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| CN104173487A (en) * | 2014-09-12 | 2014-12-03 | 洛阳民华生物科技有限公司 | Traditional Chinese medicine warm patch for improving pain in neck, shoulder, waist and legs and preparation process thereof |
| CN108543051A (en) * | 2018-07-20 | 2018-09-18 | 河南姜生堂生物科技有限公司 | A kind of natural ginger oil composition hydrogel patch and preparation method thereof |
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| CN211461326U (en) * | 2019-12-17 | 2020-09-11 | 北京东方艾美生物技术股份有限公司 | Adhesive film for wound surface |
| CN112057585A (en) * | 2020-09-30 | 2020-12-11 | 洛阳新坐标生物工程有限公司 | Formula of patch containing multiple essential oils for treating pain in neck, shoulder, waist and leg and preparation method thereof |
| WO2022248583A1 (en) * | 2021-05-25 | 2022-12-01 | Cs Medica A/S | Pain relief patch |
| CN218165609U (en) * | 2021-09-01 | 2022-12-30 | 广州纽得赛生物科技有限公司 | Moxibustion plaster |
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2023
- 2023-06-26 CN CN202310754751.1A patent/CN116919928B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173487A (en) * | 2014-09-12 | 2014-12-03 | 洛阳民华生物科技有限公司 | Traditional Chinese medicine warm patch for improving pain in neck, shoulder, waist and legs and preparation process thereof |
| CN108543051A (en) * | 2018-07-20 | 2018-09-18 | 河南姜生堂生物科技有限公司 | A kind of natural ginger oil composition hydrogel patch and preparation method thereof |
| CN109589344A (en) * | 2018-11-09 | 2019-04-09 | 湖北李时珍现代生物医药集团有限公司 | One kind begging moxibustion plaster and preparation method thereof |
| CN211461326U (en) * | 2019-12-17 | 2020-09-11 | 北京东方艾美生物技术股份有限公司 | Adhesive film for wound surface |
| CN112057585A (en) * | 2020-09-30 | 2020-12-11 | 洛阳新坐标生物工程有限公司 | Formula of patch containing multiple essential oils for treating pain in neck, shoulder, waist and leg and preparation method thereof |
| WO2022248583A1 (en) * | 2021-05-25 | 2022-12-01 | Cs Medica A/S | Pain relief patch |
| CN218165609U (en) * | 2021-09-01 | 2022-12-30 | 广州纽得赛生物科技有限公司 | Moxibustion plaster |
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