CN103316078A - Sleep aiding and cooling patch and preparation method thereof - Google Patents
Sleep aiding and cooling patch and preparation method thereof Download PDFInfo
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- CN103316078A CN103316078A CN201310247118XA CN201310247118A CN103316078A CN 103316078 A CN103316078 A CN 103316078A CN 201310247118X A CN201310247118X A CN 201310247118XA CN 201310247118 A CN201310247118 A CN 201310247118A CN 103316078 A CN103316078 A CN 103316078A
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Abstract
The invention discloses a sleep aiding and cooling patch and a preparation method thereof. The patch consists of a backing layer, a gel layer and a release film; the gel layer consists of 5 to 15 parts of macromolecular substance, 0.2 to 2 parts of cross-linking agent and crosslink conditioning agent, 10 to 30 parts of humectant, 0.01 to 0.5 part of asbolin, 0.01 to 0.05 part of lavender essential oil, 0.01 to 0.05 part of menthol, 0.2 to 1 part of alcohol and 55 to 85 parts of purified water. The patch disclosed by the invention adopts a transdermal drug delivery system (TDDS) technology, and the nerves calming and sleep aiding effects of the asbolin and the lavender essential oil and the cooling and refreshing effects of the menthol and the alcohol are integrated to prepare a hydrogel patch. The sleep aiding and cooling patch disclosed by the invention is convenient to use, can be adhered repeatedly, does not hurt the skin, does not have residue, toxicity or harm, has fragrant and pleasant smell and lasting sleep aiding and cooling effects, and is particularly suitable for cooling in fever and summer.
Description
Technical field
The invention belongs to medical technical field, relate to a kind of easypro dormancy temperature-reducing paste.
Technical background
Temperature-reducing paste also is known as defervescence plaster used, is affixed on the human body skin surface, utilizes the TDDS technology of international popular to make moisture and drug transdermal enter skin, and the physical change of then absorbing heat by water vapor reaches falls hypothermic effect.It belongs to the Physical temperature-lowering articles for use, is widely used in fever of children fever and summer-heat removing.Temperature-reducing paste composition in the market mainly take polymer substance and Mentholum, Borneolum Syntheticum as main, only has simple cooling effect, without the dormancy effect of relaxing.No matter and fever heating or summer-heat are unbearable, all easily make the people irritated, headache, whole body is uncomfortable, sleeping also difficulty.Be more suitable for using the temperature-reducing paste with easypro dormancy effect this moment.
Remainingly after the pinaster stump wood temples part in asbolin system overcutting forest zone is rotten close that fat is partly collected, dry distilling gained liquid, the effect of tranquillizing and allaying excitement is arranged.The inhalant that asbolin is made belongs to nonprescription drugs, as the adjuvant drug use of insomnia.
Herba Lysimachiae foenum-graeci quintessence oil is refined by lavandula angustifolia and forms, and is usually used in controlling oily skin protection and fatigue alleviating, and relieving mental strain and helping sleep is had preferably effect.The quiet and beautiful fragrance of lavandula angustifolia is also extensively liked in addition, so Herba Lysimachiae foenum-graeci quintessence oil more is widely used as essence and flavoring agent.
Mentholum is the white crystal that extracts by in the leaf of Herba Menthae and the stem, and its clearing away heat and removing summer effect and unique refrigerant sense thereof make it be widely used in each field such as menthocamphorate processed, analgesic, toothpaste, confection, beverage.
Asbolin, Herba Lysimachiae foenum-graeci quintessence oil and Mentholum all derive from natural plant extracts, and safe without toxic side effect is combined together, and unique pleasant delicate fragrance is arranged, add in the gel slowly to discharge, and lasting fragrance, relieving mental strain and helping sleep is more conducive to the performance of cooling effect.
Summary of the invention
The object of the present invention is to provide a kind of patch of dormancy and cooling effect and preparation method thereof that relaxes that has.
The present invention is achieved by the following technical solutions:
A kind of easypro dormancy cooling patch and preparation method thereof, it is characterized in that: be comprised of backing layer, gel layer and mould release membrance, gel layer is made of the component of following percentage by weight: polymer substance 5-15 part, cross-linking agent and cross-linking regulator 0.2-2 part, wetting agent 10-30 part, asbolin 0.01-0.05 part, Herba Lysimachiae foenum-graeci quintessence oil 0.01-0.05 part, Mentholum 0.01-0.05 part, ethanol 0.2-1 part, purified water 55-85 part.
Described polymer substance is one or more the mixture in carbomer, carboxymethyl cellulose, hypromellose, sodium polyacrylate, gelatin, polyvinyl alcohol, the polyvinylpyrrolidone.
Described cross-linking agent is one or more the mixture in aluminum, aluminum chloride, aluminium sesquioxide, the dihydroxyaluminum aminoacetate, and cross-linking regulator is one or more the mixture in citric acid, tartaric acid, glacial acetic acid, citric acid, the formic acid.The ratio of cross-linking agent and cross-linking regulator 1: 0.5～5.
Described wetting agent is one or more the mixture in glycerol, propylene glycol, Polyethylene Glycol, the vitamin E.
Described backing layer is non-woven fabrics or stretch fabric.
Described mould release membrance is PE film or PET film.
A kind of preparation method of easypro dormancy cooling patch is as follows:
(1) gets polymer substance and cross-linking regulator adds purified water, stirring and dissolving;
(2) get cross-linking agent and wetting agent mixing and stirring;
(3) above-mentioned two solution are mixed into uniform gel;
(4) get asbolin, Herba Lysimachiae foenum-graeci quintessence oil, Mentholum dissolve with ethanol, add in the gel, stir;
(5) the above-mentioned gel for preparing is applied on the backing through coating machine, covers simultaneously mould release membrance;
(6) cut into required size and shape, packing.
Advantage of the present invention is: the invention provides a kind of hydrogel patch that relaxes and sleep and lower the temperature double effects that has, and easy to use, can repeatedly paste, do not hinder skin, noresidue, abnormal smells from the patient delicate fragrance is pleasant, nontoxic, relax dormancy and cooling effect are lasting, are particularly useful for fever heating and the cooling of relieving summer heat.
The specific embodiment
The below describes technical scheme of the present invention, so that those skilled in the art understand.
One or more mixture and the cross-linking regulator of getting in the polymer substance adds purified water, stirring and dissolving; Get one or more the mixture in cross-linking agent and the wetting agent, stir; These two kinds of solution are mixed into uniform gel; Get asbolin, Herba Lysimachiae foenum-graeci quintessence oil, Mentholum dissolve with ethanol, add in the gel, stir; The above-mentioned gel for preparing is applied on the backing through coating machine, covers simultaneously mould release membrance; Cut into required size and shape, packing.
The different proportionings of gel component are seen following embodiment:
Embodiment 1
Get 5 parts of mass fraction carbomers, 5 parts of polyvinyl alcohol, 20 parts of glycerol, 0.1 part of aluminium sesquioxide, 0.1 part in tartaric acid, 0.02 part of asbolin, 0.02 part of Herba Lysimachiae foenum-graeci quintessence oil, 0.01 part of Mentholum, 0.5 part of ethanol, 70 parts of purified water, make the cooling patch.
Embodiment 2
Get 10 parts of mass fraction sodium polyacrylate, 0.5 part of dihydroxyaluminum aminoacetate, 1 part of citric acid, 15 parts of propylene glycol, vitamin E2 part, 0.02 part of asbolin, 0.02 part of Herba Lysimachiae foenum-graeci quintessence oil, 0.01 part of Mentholum, 0.5 part of ethanol, 72 parts of purified water are made the cooling patch.
Embodiment 3
Get 10 parts of mass fraction carboxymethyl celluloses, 0.2 part of aluminium sesquioxide, 0.1 part in formic acid, 2 parts in gelatin, 3 parts of polyvinylpyrrolidones, 30 parts of glycerol, 0.02 part of asbolin, 0.02 part of Herba Lysimachiae foenum-graeci quintessence oil, 0.01 part of Mentholum, 0.5 part of ethanol, 55 parts of purified water, make the cooling patch.
Embodiment 4
Get 5 parts of mass fraction sodium polyacrylate, 0.1 part of aluminum chloride, 0.1 part of citric acid, 3 parts of hypromelloses, 15 parts of propylene glycol, vitamin E2 part, 0.02 part of asbolin, 0.02 part of Herba Lysimachiae foenum-graeci quintessence oil, 0.01 part of Mentholum, 0.5 part of ethanol, 75 parts of purified water are made the cooling patch.
Embodiment 5
Get 10 parts of mass fraction sodium polyacrylate, 0.1 part of aluminium sesquioxide, 0.1 part in tartaric acid, 15 parts of propylene glycol, 0.05 part of asbolin, 0.01 part of Herba Lysimachiae foenum-graeci quintessence oil, 0.01 part of Mentholum, 0.5 part of ethanol, 75 parts of purified water are made the cooling patch.
Embodiment 6
Get 10 parts of mass fraction sodium polyacrylate, 0.1 part of aluminium sesquioxide, 0.1 part in tartaric acid, 15 parts of propylene glycol, vitamin E2 part, 0.01 part of asbolin, 0.05 part of Herba Lysimachiae foenum-graeci quintessence oil, 0.01 part of Mentholum, 0.5 part of ethanol, 73 parts of purified water are made the cooling patch.
Embodiment 7
Get 10 parts of mass fraction sodium polyacrylate, 0.1 part of aluminium sesquioxide, 0.1 part in tartaric acid, 15 parts of propylene glycol, vitamin E2 part, 0.01 part of asbolin, 0.01 part of Herba Lysimachiae foenum-graeci quintessence oil, 0.02 part of Mentholum, 0.3 part of ethanol, 73 parts of purified water are made the cooling patch.
Above-mentioned exemplary description has been carried out in invention; obviously specific implementation of the present invention is not subjected to the restriction of aforesaid way; as long as this non-essential improvement that has adopted method design of the present invention and technical scheme to carry out; or directly apply to other occasions without improving the design that will invent and technical scheme, all within protection scope of the present invention.
Claims (7)
1. cooling patch of relax sleeping, it is characterized in that: be comprised of backing layer, gel layer and mould release membrance, gel layer is made of the component of following mass percent: polymer substance 5-15 part, cross-linking agent and cross-linking regulator 0.2-2 part, wetting agent 10-30 part, asbolin 0.01-0.05 part, Herba Lysimachiae foenum-graeci quintessence oil 0.01-0.05 part, Mentholum 0.01-0.05 part, ethanol 0.2-1 part, purified water 55-85 part.
2. a kind of easypro dormancy cooling patch according to claim 1 is characterized in that: described polymer substance is one or more the mixture in carbomer, carboxymethyl cellulose, hypromellose, sodium polyacrylate, gelatin, polyvinyl alcohol, the polyvinylpyrrolidone.
3. a kind of easypro dormancy cooling patch according to claim 1, it is characterized in that: described cross-linking agent is one or more the mixture in aluminum, aluminum chloride, aluminium sesquioxide, the dihydroxyaluminum aminoacetate, cross-linking regulator is one or more the mixture in citric acid, tartaric acid, glacial acetic acid, citric acid, the formic acid, the ratio of cross-linking agent and cross-linking regulator 1: 0.5～5.
4. a kind of easypro dormancy cooling patch according to claim 1 is characterized in that: described wetting agent is one or more the mixture in glycerol, propylene glycol, Polyethylene Glycol, the vitamin E.
5. a kind of easypro dormancy cooling patch according to claim 1, it is characterized in that: described backing layer is non-woven fabrics or stretch fabric.
6. a kind of easypro dormancy cooling patch according to claim 1, it is characterized in that: described mould release membrance is PE film or PET film.
7. the preparation method of described a kind of easypro dormancy cooling patch according to claim 1～6, it is characterized in that: described preparation method is as follows:
(1) gets polymer substance and cross-linking regulator adds purified water, stirring and dissolving;
(2) get cross-linking agent and wetting agent mixing and stirring;
(3) the two solution mix and blends of above-mentioned (1), (2) being made are made uniform gel;
(4) get asbolin, Herba Lysimachiae foenum-graeci quintessence oil, Mentholum dissolve with ethanol, add in the gel, stir;
(5) the above-mentioned gel for preparing is applied on the backing through coating machine, covers simultaneously mould release membrance;
(6) cut into required size and shape, packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310247118.XA CN103316078B (en) | 2013-06-18 | 2013-06-18 | Sleep aiding and cooling patch and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310247118.XA CN103316078B (en) | 2013-06-18 | 2013-06-18 | Sleep aiding and cooling patch and preparation method thereof |
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| CN103316078A true CN103316078A (en) | 2013-09-25 |
| CN103316078B CN103316078B (en) | 2015-01-14 |
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Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877168A (en) * | 2014-02-26 | 2014-06-25 | 高雄英 | Health-care fever cooling patch |
| CN104337796A (en) * | 2014-10-12 | 2015-02-11 | 浙江欧洁科技股份有限公司 | Polymeric hydrogel fever cooling patch for children and preparation method thereof |
| CN104352483A (en) * | 2014-10-17 | 2015-02-18 | 南京斯瑞奇医疗用品有限公司 | Air conditioner paste with refrigeration function |
| CN104436206A (en) * | 2014-12-17 | 2015-03-25 | 广西德之然生物科技有限公司 | Plant colloidal material for preparing fever cooling patches and preparation method of plant colloidal material |
| CN104547023A (en) * | 2015-01-23 | 2015-04-29 | 广州九润生物科技有限公司 | Day and night fever-cooling patches |
| CN104688813A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Nerve-soothing and eye-relaxing pad and preparation method thereof |
| CN104688880A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Headache-relieving pad and preparation method thereof |
| CN104706768A (en) * | 2015-03-12 | 2015-06-17 | 施敬东 | Patch capable of calming nerves and helping sleep and preparation method of patch |
| CN105168118A (en) * | 2015-09-30 | 2015-12-23 | 安徽丰乐香料有限责任公司 | Preparation method of natural menthol or peppermint oil hydrogel |
| CN105878218A (en) * | 2016-04-21 | 2016-08-24 | 吴美燕 | Preparation method of intelligent children's fever cooling patch |
| CN105919981A (en) * | 2016-06-28 | 2016-09-07 | 江苏迪沃生物制品有限公司 | Defervescence patch and preparation process thereof |
| CN106421540A (en) * | 2016-12-28 | 2017-02-22 | 四川默森药业有限公司 | Patch for soft tissue damage and preparation method of patch |
| EP3145501A1 (en) * | 2014-05-20 | 2017-03-29 | LTS Lohmann Therapie-Systeme AG | Transdermal therapeutic system containing lavender oil |
| CN106729415A (en) * | 2016-12-31 | 2017-05-31 | 唐山天恩科技有限公司 | Scar of dispelling gel rubber plaster and preparation method thereof |
| CN107115173A (en) * | 2017-06-13 | 2017-09-01 | 合肥旁耘科技有限公司 | One kind water suction cooling paster and preparation method thereof |
| CN108066806A (en) * | 2016-11-10 | 2018-05-25 | 天津市赛远保健品有限公司 | A kind of novel environment friendly cold compress patch |
| CN111012764A (en) * | 2019-12-24 | 2020-04-17 | 广州世和生物科技有限公司 | Testis cooling patch and preparation method thereof |
| CN111265479A (en) * | 2020-03-10 | 2020-06-12 | 中山市天图精细化工有限公司 | Cold aerosol patch and preparation method thereof |
| CN111297906A (en) * | 2019-11-14 | 2020-06-19 | 青岛兔护士海洋生物科技有限公司 | Bear gall cooling patch and preparation method thereof |
| CN114917206A (en) * | 2022-05-06 | 2022-08-19 | 江苏益仁堂生物科技有限公司 | Medical cold compress patch and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105687446A (en) * | 2016-04-21 | 2016-06-22 | 吴美燕 | Preparation method of intelligent traditional Chinese medicine fever abatement paste |
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Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877168A (en) * | 2014-02-26 | 2014-06-25 | 高雄英 | Health-care fever cooling patch |
| EP3145501A1 (en) * | 2014-05-20 | 2017-03-29 | LTS Lohmann Therapie-Systeme AG | Transdermal therapeutic system containing lavender oil |
| EP3145501B1 (en) * | 2014-05-20 | 2024-02-21 | LTS Lohmann Therapie-Systeme AG | Transdermal therapeutic system containing lavender oil |
| CN107073058A (en) * | 2014-05-20 | 2017-08-18 | Lts勒曼治疗系统股份公司 | Transdermal therapeutic system comprising lavender oil |
| CN104337796A (en) * | 2014-10-12 | 2015-02-11 | 浙江欧洁科技股份有限公司 | Polymeric hydrogel fever cooling patch for children and preparation method thereof |
| CN104352483A (en) * | 2014-10-17 | 2015-02-18 | 南京斯瑞奇医疗用品有限公司 | Air conditioner paste with refrigeration function |
| CN104436206A (en) * | 2014-12-17 | 2015-03-25 | 广西德之然生物科技有限公司 | Plant colloidal material for preparing fever cooling patches and preparation method of plant colloidal material |
| CN104436206B (en) * | 2014-12-17 | 2018-09-21 | 广西德之然生物科技有限公司 | A kind of plant colloidal materials and preparation method thereof preparing defervescence plaster used use |
| CN104547023A (en) * | 2015-01-23 | 2015-04-29 | 广州九润生物科技有限公司 | Day and night fever-cooling patches |
| CN104688880A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Headache-relieving pad and preparation method thereof |
| CN104706768A (en) * | 2015-03-12 | 2015-06-17 | 施敬东 | Patch capable of calming nerves and helping sleep and preparation method of patch |
| CN104688813A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Nerve-soothing and eye-relaxing pad and preparation method thereof |
| CN105168118A (en) * | 2015-09-30 | 2015-12-23 | 安徽丰乐香料有限责任公司 | Preparation method of natural menthol or peppermint oil hydrogel |
| CN105878218A (en) * | 2016-04-21 | 2016-08-24 | 吴美燕 | Preparation method of intelligent children's fever cooling patch |
| CN105919981A (en) * | 2016-06-28 | 2016-09-07 | 江苏迪沃生物制品有限公司 | Defervescence patch and preparation process thereof |
| CN108066806A (en) * | 2016-11-10 | 2018-05-25 | 天津市赛远保健品有限公司 | A kind of novel environment friendly cold compress patch |
| CN106421540A (en) * | 2016-12-28 | 2017-02-22 | 四川默森药业有限公司 | Patch for soft tissue damage and preparation method of patch |
| CN106729415A (en) * | 2016-12-31 | 2017-05-31 | 唐山天恩科技有限公司 | Scar of dispelling gel rubber plaster and preparation method thereof |
| CN107115173A (en) * | 2017-06-13 | 2017-09-01 | 合肥旁耘科技有限公司 | One kind water suction cooling paster and preparation method thereof |
| CN111297906A (en) * | 2019-11-14 | 2020-06-19 | 青岛兔护士海洋生物科技有限公司 | Bear gall cooling patch and preparation method thereof |
| CN111297906B (en) * | 2019-11-14 | 2023-06-09 | 青岛兔护士海洋生物科技有限公司 | Bear gall cooling patch and preparation method thereof |
| CN111012764A (en) * | 2019-12-24 | 2020-04-17 | 广州世和生物科技有限公司 | Testis cooling patch and preparation method thereof |
| CN111265479A (en) * | 2020-03-10 | 2020-06-12 | 中山市天图精细化工有限公司 | Cold aerosol patch and preparation method thereof |
| CN114917206A (en) * | 2022-05-06 | 2022-08-19 | 江苏益仁堂生物科技有限公司 | Medical cold compress patch and preparation method thereof |
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Inventor after: Tao Chunlei Inventor after: Zhang Sheng Inventor after: Hong Lian Inventor before: Tao Chunlei |
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Address after: Tianda high tech Zone 230000 Hefei Road, Anhui province No. 71 Huayi Science Park building D2 Room 601 Patentee after: Anhui Wanbang Pharmaceutical Technology Co.,Ltd. Address before: Tianda high tech Zone 230000 Hefei Road, Anhui province No. 71 Huayi Science Park building D2 Room 601 Patentee before: ANHUI WANBANG MEDICAL TECHNOLOGY Co.,Ltd. |
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