CN104337796A - Polymeric hydrogel fever cooling patch for children and preparation method thereof - Google Patents
Polymeric hydrogel fever cooling patch for children and preparation method thereof Download PDFInfo
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- CN104337796A CN104337796A CN201410534070.5A CN201410534070A CN104337796A CN 104337796 A CN104337796 A CN 104337796A CN 201410534070 A CN201410534070 A CN 201410534070A CN 104337796 A CN104337796 A CN 104337796A
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Abstract
The invention discloses a polymeric hydrogel fever cooling patch for children, which is composed of a backing layer, an anti-sticking layer and a hydrogel layer, wherein the backing layer is made from non-woven fabric; the anti-sticking layer is a PET film, a PC film or a PU film; the hydrogel layer comprises the following raw materials in percentage: a macromolecular substance, a moisturizing factor, menthol, borneol, distilled water and ethanol; the macromolecular substance is one or more of sodium polyacrylate, sodium alginate, polyvinylpyrrolidone, sodium carboxymethylcellulose and polyvinyl alcohol; and the moisturizing factor is one or more of glycerol, propylene glycol, polyethylene glycol and olive oil. The fever cooling patch disclosed by the invention, by loading mass water and little natural freshener in polymeric gel, can achieve effects of cooling and relieving fever; the fever cooling patch integrates functions of physical cooling and cooling through the natural refresher, and has excellent biocompatibility; the fever cooling patch is free from toxic and side effects, safe and reliable, capable of physically cooling and relieving pain, remarkable in fever relieving effect, and simple and feasible in preparation process.
Description
Technical field
The present invention relates to medical art, specifically a kind of macromolecule hydrogel child is defervescence plaster used and preparation method thereof.
Background technology
Infantile fever is common frdquently encountered disease, as processed not in time, can affect the healthy of children's, and existing cooling and antipyretic febrifuge side effect greatly, are mostly oral medicine, are unfavorable for that children's uses.Defervescence plaster used is exterior patch, is attached on human body skin, is external Physical temperature-lowering mode completely, mainly draws human heat's vaporization by the moisture in gel, reaches the effect of cooling zero side effect.It is a kind of is the hydrogel that substrate is made with water-soluble high-molecular material, has that water content is large, good permeability, cooling-down effect obvious, with the good biocompatibility of skin, the advantage such as non-stimulated, residual.Defervescence plaster usedly to be widely used in the country such as Japanese, American-European, but the Physical temperature-lowering that the infantile umbilical paste at present in Chinese market is mostly just simple, hold time short, and the quality of homemade goods, performance are all not as overseas-funded enterprise's product, there is the shortcomings such as skin affinity is poor, adhesive force little Yi comes off, study space widely so have.
Macromolecule hydrogel is a kind of three-dimensional network, hydrophilic but water-fast functional high molecule material, can be swelling in water, and keeps large quantity of moisture and don't dissolving, has good hydrophilic and biocompatibility.
Summary of the invention
The object of the present invention is to provide a kind of moisture retention good, safe and reliable, effective, do not come off on skin, the macromolecule hydrogel child of noresidue is defervescence plaster used, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
A kind of macromolecule hydrogel child is defervescence plaster used, be made up of backing layer, adherent layer and hydrogel layer, hydrogel layer is coated on backing layer, adherent layer is pressed on hydrogel layer, and described hydrogel layer comprises according to the raw material of content mass percent: polymer substance 10% ~ 20%, Moisture factor 5% ~ 15%, menthol 0.08% ~ 1%, Borneolum Syntheticum 0.01% ~ 0.5%, distilled water 73% ~ 90%, ethanol 0.2% ~ 2.0%;
As the further scheme of the present invention: described backing layer is non-woven fabrics.
As the further scheme of the present invention: described adherent layer is PET film, PC film or PU film.
As the further scheme of the present invention: described polymer substance is one or more in sodium polyacrylate, sodium alginate, polyvinylpyrrolidone, sodium carboxymethyl cellulose and polyvinyl alcohol.
As the present invention's further scheme: described Moisture factor is one or more of glycerol, propylene glycol, Polyethylene Glycol and olive oil.
The preparation method that described macromolecule hydrogel child is defervescence plaster used, comprises the steps: that menthol is dissolved mix homogeneously in ethanol and obtains solution A by (1), Borneolum Syntheticum is dissolved mix homogeneously in ethanol and obtain solution B; (2) Moisture factor, solution A and solution B are joined in distilled water to be uniformly mixed obtain solution C; (3) polymer substance of needs heating being joined temperature is that in the distilled water of 60 DEG C ~ 90 DEG C, after polymer substance fully dissolves, cooling down obtains hydrogel I; (4) in solution C, add one or more polymer substances successively and stir to fully swelling and obtain hydrogel II, after hydrogel I and hydrogel II mix homogeneously are obtained hydrogel layer, being cooled to room temperature; (5) be coated with on non-woven fabrics with hydrogel layer, coating layer thickness is 0.25mm ~ 1mm, shears to obtain defervescence plaster used semi-finished product; (6) defervescence plaster used semi-finished product are placed after 22 ~ 26h in room temperature, press adherent layer, be packaged to be defervescence plaster used finished product.
Compared with prior art, the invention has the beneficial effects as follows:
A large amount of water and a small amount of natural freshener are carried in high-molecular gel by the present invention, are absorbed heat by evaporation of water, the heat produced when taking away human body fever, thus reach the effect of lowering the temperature and bringing down a fever, there is the double effects that Physical temperature-lowering and natural freshener are lowered the temperature, there is good biocompatibility, nontoxic, have no side effect, safe and reliable, Physical temperature-lowering, alleviating pain, successful of bringing down a fever, preparation process is simple, effectively can treat child's fever, heating, have a headache and cool the relieving summer heat that disappear.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
The preparation method that macromolecule hydrogel child is defervescence plaster used, comprises the steps: that 4g menthol is dissolved in mix homogeneously in 6mL ethanol and obtains solution A by (1), 3g Borneolum Syntheticum is dissolved in mix homogeneously in 9mL ethanol and obtains solution B; (2) 10g glycerol, 0.9g solution A and 5 solution B join in 80g distilled water to be uniformly mixed and obtain solution C; (3) in solution C, slowly add 10g sodium polyacrylate powder and stir to fully swelling and obtain hydrogel; (4) hydrogel is coated with on non-woven fabrics, coating layer thickness 0.35mm, shears to obtain defervescence plaster used semi-finished product; (6) defervescence plaster used semi-finished product are placed after 24h in room temperature, press adherent layer, be packaged to be defervescence plaster used finished product.
Embodiment 2
The preparation method that macromolecule hydrogel child is defervescence plaster used, comprises the steps: that 0.5g menthol is dissolved in mix homogeneously in 2mL ethanol and obtains solution A by (1); (2) 6g glycerol, 5g propylene glycol, 2g olive oil, solution A are joined in 85g distilled water to be uniformly mixed and obtain solution C; (3) 1g sodium alginate being joined temperature is in the distilled water of 80 DEG C, and after sodium alginate fully dissolves, cooling down obtains hydrogel I; (4) in solution C, add 12g sodium polyacrylate powder lentamente successively and stir to fully swelling and obtain hydrogel II, after hydrogel I and hydrogel II mix homogeneously are obtained hydrogel layer, being cooled to room temperature; (5) be coated with on non-woven fabrics with hydrogel layer, coating layer thickness is 0.5mm, shears to obtain defervescence plaster used semi-finished product; (6) defervescence plaster used semi-finished product are placed after 24h in room temperature, press adherent layer, be packaged to be defervescence plaster used finished product.
Embodiment 3
The preparation method that macromolecule hydrogel child is defervescence plaster used, comprises the steps: that 5g menthol is dissolved in mix homogeneously in 10mL ethanol and obtains solution A by (1); (2) 8g glycerol, 2g propylene glycol, 2g solution A are joined in 80g distilled water to be uniformly mixed and obtain solution C; (3) 1g sodium alginate and 1.5g sodium carboxymethyl cellulose being joined 17.5g temperature is in the distilled water of 80 DEG C, and after sodium alginate and sodium carboxymethyl cellulose fully dissolve, cooling down obtains hydrogel I; (4) in solution C, add 10g sodium polyacrylate powder successively and stir to fully swelling and obtain hydrogel II, after hydrogel I and hydrogel II mix homogeneously are obtained hydrogel layer, being cooled to room temperature; (5) be coated with on non-woven fabrics with hydrogel layer, coating layer thickness is 0.3mm, shears to obtain defervescence plaster used semi-finished product; (6) defervescence plaster used semi-finished product are placed after 24h in room temperature, press adherent layer, be packaged to be defervescence plaster used finished product.
Embodiment 4
The preparation method that macromolecule hydrogel child is defervescence plaster used, comprises the steps: that 10g menthol is dissolved in mix homogeneously in 30mL ethanol and obtains solution A by (1), 5g Borneolum Syntheticum is dissolved in mix homogeneously in 20mL ethanol and obtains solution B; (2) 8g glycerol, 5g propylene glycol, 1g solution A and 0.2g solution B are joined in 85g distilled water to be uniformly mixed obtain solution C; (3) joined by 3g polyvinyl alcohol in the 18g distilled water in the water-bath of 75 DEG C, after polyvinyl alcohol fully dissolves, cooling down obtains hydrogel I; (4) in solution C, add 15g sodium polyacrylate powder successively and stir to fully swelling and obtain hydrogel II, after hydrogel I and hydrogel II mix homogeneously are obtained hydrogel layer, being cooled to room temperature; (5) be coated with on non-woven fabrics with hydrogel layer, coating layer thickness is 0.45mm, shears to obtain defervescence plaster used semi-finished product; (6) defervescence plaster used semi-finished product are placed after 24h in room temperature, press adherent layer, be packaged to be defervescence plaster used finished product.
A large amount of water and a small amount of natural freshener are carried in high-molecular gel by the present invention, are absorbed heat by evaporation of water, the heat produced when taking away human body fever, thus reach the effect of lowering the temperature and bringing down a fever, there is the double effects that Physical temperature-lowering and natural freshener are lowered the temperature, there is good biocompatibility, nontoxic, have no side effect, safe and reliable, Physical temperature-lowering, alleviating pain, successful of bringing down a fever, preparation process is simple, effectively can treat child's fever, heating, have a headache and cool the relieving summer heat that disappear.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (6)
1. a macromolecule hydrogel child is defervescence plaster used, be made up of backing layer, adherent layer and hydrogel layer, hydrogel layer is coated on backing layer, adherent layer is pressed on hydrogel layer, it is characterized in that, described hydrogel layer comprises according to the raw material of mass percent: polymer substance 10% ~ 20%, Moisture factor 5% ~ 15%, menthol 0.08% ~ 1%, Borneolum Syntheticum 0.01% ~ 0.5%, distilled water 73% ~ 90%, ethanol 0.2 ~ 2.0%.
2. macromolecule hydrogel child according to claim 1 is defervescence plaster used, it is characterized in that, described backing layer is non-woven fabrics.
3. macromolecule hydrogel child according to claim 1 is defervescence plaster used, it is characterized in that, described adherent layer is PET film, PC film or PU film.
4. defervescence plaster used according to macromolecule hydrogel child according to claim 1, it is characterized in that, polymer substance is one or more in sodium polyacrylate, sodium alginate, polyvinylpyrrolidone, sodium carboxymethyl cellulose and polyvinyl alcohol.
5. macromolecule hydrogel child according to claim 1 is defervescence plaster used, it is characterized in that, described Moisture factor is one or more of glycerol, propylene glycol, Polyethylene Glycol and olive oil.
6. one kind as arbitrary in claim 1-4 as described in the defervescence plaster used preparation method of macromolecule hydrogel child, it is characterized in that, comprise the steps: that menthol is dissolved mix homogeneously in ethanol and obtains solution A by (1), Borneolum Syntheticum is dissolved mix homogeneously in ethanol and obtain solution B; (2) Moisture factor, solution A and solution B are joined in distilled water to be uniformly mixed obtain solution C; (3) polymer substance of needs heating being joined temperature is that in the distilled water of 60 DEG C ~ 90 DEG C, after polymer substance fully dissolves, cooling down obtains hydrogel I; (4) in solution C, add one or more polymer substances successively and stir to fully swelling and obtain hydrogel II, after hydrogel I and hydrogel II mix homogeneously are obtained hydrogel layer, being cooled to room temperature; (5) be coated with on non-woven fabrics with hydrogel layer, coating layer thickness is 0.25mm ~ 1mm, shears to obtain defervescence plaster used semi-finished product; (6) defervescence plaster used semi-finished product are placed after 22 ~ 26h in room temperature, press adherent layer, be packaged to be defervescence plaster used finished product.
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| CN201410534070.5A CN104337796A (en) | 2014-10-12 | 2014-10-12 | Polymeric hydrogel fever cooling patch for children and preparation method thereof |
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| CN201410534070.5A CN104337796A (en) | 2014-10-12 | 2014-10-12 | Polymeric hydrogel fever cooling patch for children and preparation method thereof |
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Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688880A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Headache-relieving pad and preparation method thereof |
| CN105168208A (en) * | 2015-06-30 | 2015-12-23 | 武汉烺祺生物科技有限公司 | Externally used drug for abating fever and preventing sunstroke |
| CN105687446A (en) * | 2016-04-21 | 2016-06-22 | 吴美燕 | Preparation method of intelligent traditional Chinese medicine fever abatement paste |
| CN105878218A (en) * | 2016-04-21 | 2016-08-24 | 吴美燕 | Preparation method of intelligent children's fever cooling patch |
| CN105919981A (en) * | 2016-06-28 | 2016-09-07 | 江苏迪沃生物制品有限公司 | Defervescence patch and preparation process thereof |
| CN105998251A (en) * | 2016-06-17 | 2016-10-12 | 刘泰 | Preparation method of antipyretic patch |
| CN107080768A (en) * | 2017-04-27 | 2017-08-22 | 王天湶 | A kind of dual effect type gel bring down a fever patch and preparation method thereof |
| CN107115173A (en) * | 2017-06-13 | 2017-09-01 | 合肥旁耘科技有限公司 | One kind water suction cooling paster and preparation method thereof |
| CN107296681A (en) * | 2017-06-30 | 2017-10-27 | 成都磁动势科技有限公司 | Magnetomotive bring down a fever patch and preparation method thereof |
| CN107320578A (en) * | 2017-07-21 | 2017-11-07 | 福建农林大学 | A kind of glucomannan hydrogel of konnjaku infant bring down a fever patch and preparation method thereof |
| CN108096224A (en) * | 2017-12-30 | 2018-06-01 | 张静 | A kind of infantile umbilical paste |
| CN108186615A (en) * | 2018-03-23 | 2018-06-22 | 青岛海洋生物医药研究院 | It is a kind of degradable defervescence plaster used and preparation method thereof |
| CN108670540A (en) * | 2018-06-05 | 2018-10-19 | 湖南医家智烯新材料科技股份有限公司 | Temperature-reducing paste and preparation method thereof |
| CN108815140A (en) * | 2018-07-30 | 2018-11-16 | 合肥仙之峰农业科技有限公司 | A kind of retreat stickers of long-acting slow cooling |
| CN109498255A (en) * | 2018-12-18 | 2019-03-22 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | A kind of efficient heat transfer type is defervescence plaster used |
| CN109568004A (en) * | 2019-01-31 | 2019-04-05 | 浙江金壳医疗科技有限公司 | A kind of Medical cold application and preparation method thereof |
| CN111297906A (en) * | 2019-11-14 | 2020-06-19 | 青岛兔护士海洋生物科技有限公司 | Bear gall cooling patch and preparation method thereof |
| CN111437432A (en) * | 2020-04-17 | 2020-07-24 | 常州美洛医疗科技有限公司 | Preparation method of graphene physical antibacterial hydrogel dressing |
| CN111450048A (en) * | 2020-04-19 | 2020-07-28 | 田文超 | Gel for antipyretic patch and preparation method thereof |
| CN111568631A (en) * | 2020-04-23 | 2020-08-25 | 武汉中科先进技术研究院有限公司 | Cooling paste with temperature indication function and preparation method thereof |
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Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688880A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Headache-relieving pad and preparation method thereof |
| CN105168208A (en) * | 2015-06-30 | 2015-12-23 | 武汉烺祺生物科技有限公司 | Externally used drug for abating fever and preventing sunstroke |
| CN105168208B (en) * | 2015-06-30 | 2019-01-01 | 武汉烺祺生物科技有限公司 | A kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever |
| CN105687446A (en) * | 2016-04-21 | 2016-06-22 | 吴美燕 | Preparation method of intelligent traditional Chinese medicine fever abatement paste |
| CN105878218A (en) * | 2016-04-21 | 2016-08-24 | 吴美燕 | Preparation method of intelligent children's fever cooling patch |
| CN105998251A (en) * | 2016-06-17 | 2016-10-12 | 刘泰 | Preparation method of antipyretic patch |
| CN105919981A (en) * | 2016-06-28 | 2016-09-07 | 江苏迪沃生物制品有限公司 | Defervescence patch and preparation process thereof |
| CN107080768A (en) * | 2017-04-27 | 2017-08-22 | 王天湶 | A kind of dual effect type gel bring down a fever patch and preparation method thereof |
| CN107115173A (en) * | 2017-06-13 | 2017-09-01 | 合肥旁耘科技有限公司 | One kind water suction cooling paster and preparation method thereof |
| CN107296681A (en) * | 2017-06-30 | 2017-10-27 | 成都磁动势科技有限公司 | Magnetomotive bring down a fever patch and preparation method thereof |
| CN107320578A (en) * | 2017-07-21 | 2017-11-07 | 福建农林大学 | A kind of glucomannan hydrogel of konnjaku infant bring down a fever patch and preparation method thereof |
| CN108096224A (en) * | 2017-12-30 | 2018-06-01 | 张静 | A kind of infantile umbilical paste |
| CN108186615A (en) * | 2018-03-23 | 2018-06-22 | 青岛海洋生物医药研究院 | It is a kind of degradable defervescence plaster used and preparation method thereof |
| CN108186615B (en) * | 2018-03-23 | 2021-02-02 | 青岛海洋生物医药研究院 | Degradable fever cooling patch and preparation method thereof |
| CN108670540A (en) * | 2018-06-05 | 2018-10-19 | 湖南医家智烯新材料科技股份有限公司 | Temperature-reducing paste and preparation method thereof |
| CN108815140A (en) * | 2018-07-30 | 2018-11-16 | 合肥仙之峰农业科技有限公司 | A kind of retreat stickers of long-acting slow cooling |
| CN109498255A (en) * | 2018-12-18 | 2019-03-22 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | A kind of efficient heat transfer type is defervescence plaster used |
| CN109568004A (en) * | 2019-01-31 | 2019-04-05 | 浙江金壳医疗科技有限公司 | A kind of Medical cold application and preparation method thereof |
| CN111297906A (en) * | 2019-11-14 | 2020-06-19 | 青岛兔护士海洋生物科技有限公司 | Bear gall cooling patch and preparation method thereof |
| CN111297906B (en) * | 2019-11-14 | 2023-06-09 | 青岛兔护士海洋生物科技有限公司 | Bear gall cooling patch and preparation method thereof |
| CN111437432A (en) * | 2020-04-17 | 2020-07-24 | 常州美洛医疗科技有限公司 | Preparation method of graphene physical antibacterial hydrogel dressing |
| CN111450048A (en) * | 2020-04-19 | 2020-07-28 | 田文超 | Gel for antipyretic patch and preparation method thereof |
| CN111450048B (en) * | 2020-04-19 | 2023-12-22 | 广州市雨纯生物科技有限公司 | Gel for antipyretic patch and preparation method thereof |
| CN111568631A (en) * | 2020-04-23 | 2020-08-25 | 武汉中科先进技术研究院有限公司 | Cooling paste with temperature indication function and preparation method thereof |
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