CN104337796A - Polymeric hydrogel fever cooling patch for children and preparation method thereof - Google Patents
Polymeric hydrogel fever cooling patch for children and preparation method thereof Download PDFInfo
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- CN104337796A CN104337796A CN201410534070.5A CN201410534070A CN104337796A CN 104337796 A CN104337796 A CN 104337796A CN 201410534070 A CN201410534070 A CN 201410534070A CN 104337796 A CN104337796 A CN 104337796A
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- defervescence plaster
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- 239000000017 hydrogel Substances 0.000 title claims abstract description 61
- 238000001816 cooling Methods 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 206010037660 Pyrexia Diseases 0.000 title abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 26
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229920002521 macromolecule Polymers 0.000 claims abstract description 18
- 239000012153 distilled water Substances 0.000 claims abstract description 14
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 9
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229940041616 menthol Drugs 0.000 claims abstract description 9
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 9
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 7
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims abstract description 7
- 239000000661 sodium alginate Substances 0.000 claims abstract description 7
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 7
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 7
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims abstract description 7
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 5
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 5
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 5
- 239000004006 olive oil Substances 0.000 claims abstract description 4
- 235000008390 olive oil Nutrition 0.000 claims abstract description 4
- 229920002799 BoPET Polymers 0.000 claims abstract description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 3
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims abstract description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 3
- 239000002994 raw material Substances 0.000 claims abstract description 3
- 239000010410 layer Substances 0.000 claims description 36
- 239000011505 plaster Substances 0.000 claims description 35
- 239000000203 mixture Substances 0.000 claims description 15
- 230000001464 adherent effect Effects 0.000 claims description 12
- 239000011265 semifinished product Substances 0.000 claims description 12
- 229920000642 polymer Polymers 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 10
- 239000000047 product Substances 0.000 claims description 7
- 230000008961 swelling Effects 0.000 claims description 7
- 239000011247 coating layer Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 11
- 239000000499 gel Substances 0.000 abstract description 4
- 208000002193 Pain Diseases 0.000 abstract description 3
- 230000003020 moisturizing effect Effects 0.000 abstract 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 239000000843 powder Substances 0.000 description 4
- 206010019233 Headaches Diseases 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a polymeric hydrogel fever cooling patch for children, which is composed of a backing layer, an anti-sticking layer and a hydrogel layer, wherein the backing layer is made from non-woven fabric; the anti-sticking layer is a PET film, a PC film or a PU film; the hydrogel layer comprises the following raw materials in percentage: a macromolecular substance, a moisturizing factor, menthol, borneol, distilled water and ethanol; the macromolecular substance is one or more of sodium polyacrylate, sodium alginate, polyvinylpyrrolidone, sodium carboxymethylcellulose and polyvinyl alcohol; and the moisturizing factor is one or more of glycerol, propylene glycol, polyethylene glycol and olive oil. The fever cooling patch disclosed by the invention, by loading mass water and little natural freshener in polymeric gel, can achieve effects of cooling and relieving fever; the fever cooling patch integrates functions of physical cooling and cooling through the natural refresher, and has excellent biocompatibility; the fever cooling patch is free from toxic and side effects, safe and reliable, capable of physically cooling and relieving pain, remarkable in fever relieving effect, and simple and feasible in preparation process.
Description
Technical field
The present invention relates to medical art, specifically a kind of macromolecule hydrogel child is defervescence plaster used and preparation method thereof.
Background technology
Infantile fever is common frdquently encountered disease, as processed not in time, can affect the healthy of children's, and existing cooling and antipyretic febrifuge side effect greatly, are mostly oral medicine, are unfavorable for that children's uses.Defervescence plaster used is exterior patch, is attached on human body skin, is external Physical temperature-lowering mode completely, mainly draws human heat's vaporization by the moisture in gel, reaches the effect of cooling zero side effect.It is a kind of is the hydrogel that substrate is made with water-soluble high-molecular material, has that water content is large, good permeability, cooling-down effect obvious, with the good biocompatibility of skin, the advantage such as non-stimulated, residual.Defervescence plaster usedly to be widely used in the country such as Japanese, American-European, but the Physical temperature-lowering that the infantile umbilical paste at present in Chinese market is mostly just simple, hold time short, and the quality of homemade goods, performance are all not as overseas-funded enterprise's product, there is the shortcomings such as skin affinity is poor, adhesive force little Yi comes off, study space widely so have.
Macromolecule hydrogel is a kind of three-dimensional network, hydrophilic but water-fast functional high molecule material, can be swelling in water, and keeps large quantity of moisture and don't dissolving, has good hydrophilic and biocompatibility.
Summary of the invention
The object of the present invention is to provide a kind of moisture retention good, safe and reliable, effective, do not come off on skin, the macromolecule hydrogel child of noresidue is defervescence plaster used, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
A kind of macromolecule hydrogel child is defervescence plaster used, be made up of backing layer, adherent layer and hydrogel layer, hydrogel layer is coated on backing layer, adherent layer is pressed on hydrogel layer, and described hydrogel layer comprises according to the raw material of content mass percent: polymer substance 10% ~ 20%, Moisture factor 5% ~ 15%, menthol 0.08% ~ 1%, Borneolum Syntheticum 0.01% ~ 0.5%, distilled water 73% ~ 90%, ethanol 0.2% ~ 2.0%;
As the further scheme of the present invention: described backing layer is non-woven fabrics.
As the further scheme of the present invention: described adherent layer is PET film, PC film or PU film.
As the further scheme of the present invention: described polymer substance is one or more in sodium polyacrylate, sodium alginate, polyvinylpyrrolidone, sodium carboxymethyl cellulose and polyvinyl alcohol.
As the present invention's further scheme: described Moisture factor is one or more of glycerol, propylene glycol, Polyethylene Glycol and olive oil.
The preparation method that described macromolecule hydrogel child is defervescence plaster used, comprises the steps: that menthol is dissolved mix homogeneously in ethanol and obtains solution A by (1), Borneolum Syntheticum is dissolved mix homogeneously in ethanol and obtain solution B; (2) Moisture factor, solution A and solution B are joined in distilled water to be uniformly mixed obtain solution C; (3) polymer substance of needs heating being joined temperature is that in the distilled water of 60 DEG C ~ 90 DEG C, after polymer substance fully dissolves, cooling down obtains hydrogel I; (4) in solution C, add one or more polymer substances successively and stir to fully swelling and obtain hydrogel II, after hydrogel I and hydrogel II mix homogeneously are obtained hydrogel layer, being cooled to room temperature; (5) be coated with on non-woven fabrics with hydrogel layer, coating layer thickness is 0.25mm ~ 1mm, shears to obtain defervescence plaster used semi-finished product; (6) defervescence plaster used semi-finished product are placed after 22 ~ 26h in room temperature, press adherent layer, be packaged to be defervescence plaster used finished product.
Compared with prior art, the invention has the beneficial effects as follows:
A large amount of water and a small amount of natural freshener are carried in high-molecular gel by the present invention, are absorbed heat by evaporation of water, the heat produced when taking away human body fever, thus reach the effect of lowering the temperature and bringing down a fever, there is the double effects that Physical temperature-lowering and natural freshener are lowered the temperature, there is good biocompatibility, nontoxic, have no side effect, safe and reliable, Physical temperature-lowering, alleviating pain, successful of bringing down a fever, preparation process is simple, effectively can treat child's fever, heating, have a headache and cool the relieving summer heat that disappear.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
The preparation method that macromolecule hydrogel child is defervescence plaster used, comprises the steps: that 4g menthol is dissolved in mix homogeneously in 6mL ethanol and obtains solution A by (1), 3g Borneolum Syntheticum is dissolved in mix homogeneously in 9mL ethanol and obtains solution B; (2) 10g glycerol, 0.9g solution A and 5 solution B join in 80g distilled water to be uniformly mixed and obtain solution C; (3) in solution C, slowly add 10g sodium polyacrylate powder and stir to fully swelling and obtain hydrogel; (4) hydrogel is coated with on non-woven fabrics, coating layer thickness 0.35mm, shears to obtain defervescence plaster used semi-finished product; (6) defervescence plaster used semi-finished product are placed after 24h in room temperature, press adherent layer, be packaged to be defervescence plaster used finished product.
Embodiment 2
The preparation method that macromolecule hydrogel child is defervescence plaster used, comprises the steps: that 0.5g menthol is dissolved in mix homogeneously in 2mL ethanol and obtains solution A by (1); (2) 6g glycerol, 5g propylene glycol, 2g olive oil, solution A are joined in 85g distilled water to be uniformly mixed and obtain solution C; (3) 1g sodium alginate being joined temperature is in the distilled water of 80 DEG C, and after sodium alginate fully dissolves, cooling down obtains hydrogel I; (4) in solution C, add 12g sodium polyacrylate powder lentamente successively and stir to fully swelling and obtain hydrogel II, after hydrogel I and hydrogel II mix homogeneously are obtained hydrogel layer, being cooled to room temperature; (5) be coated with on non-woven fabrics with hydrogel layer, coating layer thickness is 0.5mm, shears to obtain defervescence plaster used semi-finished product; (6) defervescence plaster used semi-finished product are placed after 24h in room temperature, press adherent layer, be packaged to be defervescence plaster used finished product.
Embodiment 3
The preparation method that macromolecule hydrogel child is defervescence plaster used, comprises the steps: that 5g menthol is dissolved in mix homogeneously in 10mL ethanol and obtains solution A by (1); (2) 8g glycerol, 2g propylene glycol, 2g solution A are joined in 80g distilled water to be uniformly mixed and obtain solution C; (3) 1g sodium alginate and 1.5g sodium carboxymethyl cellulose being joined 17.5g temperature is in the distilled water of 80 DEG C, and after sodium alginate and sodium carboxymethyl cellulose fully dissolve, cooling down obtains hydrogel I; (4) in solution C, add 10g sodium polyacrylate powder successively and stir to fully swelling and obtain hydrogel II, after hydrogel I and hydrogel II mix homogeneously are obtained hydrogel layer, being cooled to room temperature; (5) be coated with on non-woven fabrics with hydrogel layer, coating layer thickness is 0.3mm, shears to obtain defervescence plaster used semi-finished product; (6) defervescence plaster used semi-finished product are placed after 24h in room temperature, press adherent layer, be packaged to be defervescence plaster used finished product.
Embodiment 4
The preparation method that macromolecule hydrogel child is defervescence plaster used, comprises the steps: that 10g menthol is dissolved in mix homogeneously in 30mL ethanol and obtains solution A by (1), 5g Borneolum Syntheticum is dissolved in mix homogeneously in 20mL ethanol and obtains solution B; (2) 8g glycerol, 5g propylene glycol, 1g solution A and 0.2g solution B are joined in 85g distilled water to be uniformly mixed obtain solution C; (3) joined by 3g polyvinyl alcohol in the 18g distilled water in the water-bath of 75 DEG C, after polyvinyl alcohol fully dissolves, cooling down obtains hydrogel I; (4) in solution C, add 15g sodium polyacrylate powder successively and stir to fully swelling and obtain hydrogel II, after hydrogel I and hydrogel II mix homogeneously are obtained hydrogel layer, being cooled to room temperature; (5) be coated with on non-woven fabrics with hydrogel layer, coating layer thickness is 0.45mm, shears to obtain defervescence plaster used semi-finished product; (6) defervescence plaster used semi-finished product are placed after 24h in room temperature, press adherent layer, be packaged to be defervescence plaster used finished product.
A large amount of water and a small amount of natural freshener are carried in high-molecular gel by the present invention, are absorbed heat by evaporation of water, the heat produced when taking away human body fever, thus reach the effect of lowering the temperature and bringing down a fever, there is the double effects that Physical temperature-lowering and natural freshener are lowered the temperature, there is good biocompatibility, nontoxic, have no side effect, safe and reliable, Physical temperature-lowering, alleviating pain, successful of bringing down a fever, preparation process is simple, effectively can treat child's fever, heating, have a headache and cool the relieving summer heat that disappear.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (6)
1. a macromolecule hydrogel child is defervescence plaster used, be made up of backing layer, adherent layer and hydrogel layer, hydrogel layer is coated on backing layer, adherent layer is pressed on hydrogel layer, it is characterized in that, described hydrogel layer comprises according to the raw material of mass percent: polymer substance 10% ~ 20%, Moisture factor 5% ~ 15%, menthol 0.08% ~ 1%, Borneolum Syntheticum 0.01% ~ 0.5%, distilled water 73% ~ 90%, ethanol 0.2 ~ 2.0%.
2. macromolecule hydrogel child according to claim 1 is defervescence plaster used, it is characterized in that, described backing layer is non-woven fabrics.
3. macromolecule hydrogel child according to claim 1 is defervescence plaster used, it is characterized in that, described adherent layer is PET film, PC film or PU film.
4. defervescence plaster used according to macromolecule hydrogel child according to claim 1, it is characterized in that, polymer substance is one or more in sodium polyacrylate, sodium alginate, polyvinylpyrrolidone, sodium carboxymethyl cellulose and polyvinyl alcohol.
5. macromolecule hydrogel child according to claim 1 is defervescence plaster used, it is characterized in that, described Moisture factor is one or more of glycerol, propylene glycol, Polyethylene Glycol and olive oil.
6. one kind as arbitrary in claim 1-4 as described in the defervescence plaster used preparation method of macromolecule hydrogel child, it is characterized in that, comprise the steps: that menthol is dissolved mix homogeneously in ethanol and obtains solution A by (1), Borneolum Syntheticum is dissolved mix homogeneously in ethanol and obtain solution B; (2) Moisture factor, solution A and solution B are joined in distilled water to be uniformly mixed obtain solution C; (3) polymer substance of needs heating being joined temperature is that in the distilled water of 60 DEG C ~ 90 DEG C, after polymer substance fully dissolves, cooling down obtains hydrogel I; (4) in solution C, add one or more polymer substances successively and stir to fully swelling and obtain hydrogel II, after hydrogel I and hydrogel II mix homogeneously are obtained hydrogel layer, being cooled to room temperature; (5) be coated with on non-woven fabrics with hydrogel layer, coating layer thickness is 0.25mm ~ 1mm, shears to obtain defervescence plaster used semi-finished product; (6) defervescence plaster used semi-finished product are placed after 22 ~ 26h in room temperature, press adherent layer, be packaged to be defervescence plaster used finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410534070.5A CN104337796A (en) | 2014-10-12 | 2014-10-12 | Polymeric hydrogel fever cooling patch for children and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410534070.5A CN104337796A (en) | 2014-10-12 | 2014-10-12 | Polymeric hydrogel fever cooling patch for children and preparation method thereof |
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| CN104337796A true CN104337796A (en) | 2015-02-11 |
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| CN201410534070.5A Pending CN104337796A (en) | 2014-10-12 | 2014-10-12 | Polymeric hydrogel fever cooling patch for children and preparation method thereof |
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Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688880A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Headache-relieving pad and preparation method thereof |
| CN105168208A (en) * | 2015-06-30 | 2015-12-23 | 武汉烺祺生物科技有限公司 | Externally used drug for abating fever and preventing sunstroke |
| CN105687446A (en) * | 2016-04-21 | 2016-06-22 | 吴美燕 | Preparation method of intelligent traditional Chinese medicine fever abatement paste |
| CN105878218A (en) * | 2016-04-21 | 2016-08-24 | 吴美燕 | Preparation method of intelligent children's fever cooling patch |
| CN105919981A (en) * | 2016-06-28 | 2016-09-07 | 江苏迪沃生物制品有限公司 | Defervescence patch and preparation process thereof |
| CN105998251A (en) * | 2016-06-17 | 2016-10-12 | 刘泰 | Preparation method of antipyretic patch |
| CN107080768A (en) * | 2017-04-27 | 2017-08-22 | 王天湶 | A kind of dual effect type gel bring down a fever patch and preparation method thereof |
| CN107115173A (en) * | 2017-06-13 | 2017-09-01 | 合肥旁耘科技有限公司 | One kind water suction cooling paster and preparation method thereof |
| CN107296681A (en) * | 2017-06-30 | 2017-10-27 | 成都磁动势科技有限公司 | Magnetomotive bring down a fever patch and preparation method thereof |
| CN107320578A (en) * | 2017-07-21 | 2017-11-07 | 福建农林大学 | A kind of glucomannan hydrogel of konnjaku infant bring down a fever patch and preparation method thereof |
| CN108096224A (en) * | 2017-12-30 | 2018-06-01 | 张静 | A kind of infantile umbilical paste |
| CN108186615A (en) * | 2018-03-23 | 2018-06-22 | 青岛海洋生物医药研究院 | It is a kind of degradable defervescence plaster used and preparation method thereof |
| CN108670540A (en) * | 2018-06-05 | 2018-10-19 | 湖南医家智烯新材料科技股份有限公司 | Temperature-reducing paste and preparation method thereof |
| CN108815140A (en) * | 2018-07-30 | 2018-11-16 | 合肥仙之峰农业科技有限公司 | A kind of retreat stickers of long-acting slow cooling |
| CN109498255A (en) * | 2018-12-18 | 2019-03-22 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | A kind of efficient heat transfer type is defervescence plaster used |
| CN109568004A (en) * | 2019-01-31 | 2019-04-05 | 浙江金壳医疗科技有限公司 | A kind of Medical cold application and preparation method thereof |
| CN111297906A (en) * | 2019-11-14 | 2020-06-19 | 青岛兔护士海洋生物科技有限公司 | Bear gall cooling patch and preparation method thereof |
| CN111437432A (en) * | 2020-04-17 | 2020-07-24 | 常州美洛医疗科技有限公司 | Preparation method of graphene physical antibacterial hydrogel dressing |
| CN111450048A (en) * | 2020-04-19 | 2020-07-28 | 田文超 | Gel for antipyretic patch and preparation method thereof |
| CN111568631A (en) * | 2020-04-23 | 2020-08-25 | 武汉中科先进技术研究院有限公司 | Cooling paste with temperature indication function and preparation method thereof |
| CN117860468A (en) * | 2024-01-09 | 2024-04-12 | 广东康美芝医疗用品科技有限公司 | Permanent effective defervescence patch |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006288305A (en) * | 2005-04-12 | 2006-10-26 | Toyoyuki Maejima | Gelidium jelly drink |
| CN102166149A (en) * | 2010-11-29 | 2011-08-31 | 吴克 | Antipyretic patch and preparation process thereof |
| WO2012118034A1 (en) * | 2011-03-02 | 2012-09-07 | 日本たばこ産業株式会社 | Method for producing flavoring-containing sheet for smoking article, flavoring-containing sheet for smoking article produced thereby, and smoking article comprising same |
| CN103316078A (en) * | 2013-06-18 | 2013-09-25 | 安徽万邦医药科技有限公司 | Sleep aiding and cooling patch and preparation method thereof |
-
2014
- 2014-10-12 CN CN201410534070.5A patent/CN104337796A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006288305A (en) * | 2005-04-12 | 2006-10-26 | Toyoyuki Maejima | Gelidium jelly drink |
| CN102166149A (en) * | 2010-11-29 | 2011-08-31 | 吴克 | Antipyretic patch and preparation process thereof |
| WO2012118034A1 (en) * | 2011-03-02 | 2012-09-07 | 日本たばこ産業株式会社 | Method for producing flavoring-containing sheet for smoking article, flavoring-containing sheet for smoking article produced thereby, and smoking article comprising same |
| CN103316078A (en) * | 2013-06-18 | 2013-09-25 | 安徽万邦医药科技有限公司 | Sleep aiding and cooling patch and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 黄玮等: "聚丙烯酸钠水凝胶基材退热贴的制备及其性能", 《功能高分子学报》 * |
Cited By (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688880A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Headache-relieving pad and preparation method thereof |
| CN105168208A (en) * | 2015-06-30 | 2015-12-23 | 武汉烺祺生物科技有限公司 | Externally used drug for abating fever and preventing sunstroke |
| CN105168208B (en) * | 2015-06-30 | 2019-01-01 | 武汉烺祺生物科技有限公司 | A kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever |
| CN105687446A (en) * | 2016-04-21 | 2016-06-22 | 吴美燕 | Preparation method of intelligent traditional Chinese medicine fever abatement paste |
| CN105878218A (en) * | 2016-04-21 | 2016-08-24 | 吴美燕 | Preparation method of intelligent children's fever cooling patch |
| CN105998251A (en) * | 2016-06-17 | 2016-10-12 | 刘泰 | Preparation method of antipyretic patch |
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| CN108096224A (en) * | 2017-12-30 | 2018-06-01 | 张静 | A kind of infantile umbilical paste |
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| CN108815140A (en) * | 2018-07-30 | 2018-11-16 | 合肥仙之峰农业科技有限公司 | A kind of retreat stickers of long-acting slow cooling |
| CN109498255A (en) * | 2018-12-18 | 2019-03-22 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | A kind of efficient heat transfer type is defervescence plaster used |
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| CN111297906A (en) * | 2019-11-14 | 2020-06-19 | 青岛兔护士海洋生物科技有限公司 | Bear gall cooling patch and preparation method thereof |
| CN111297906B (en) * | 2019-11-14 | 2023-06-09 | 青岛兔护士海洋生物科技有限公司 | Bear gall cooling patch and preparation method thereof |
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| CN111450048A (en) * | 2020-04-19 | 2020-07-28 | 田文超 | Gel for antipyretic patch and preparation method thereof |
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| CN111568631A (en) * | 2020-04-23 | 2020-08-25 | 武汉中科先进技术研究院有限公司 | Cooling paste with temperature indication function and preparation method thereof |
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