CN105168208B - A kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever - Google Patents
A kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever Download PDFInfo
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- CN105168208B CN105168208B CN201510372573.1A CN201510372573A CN105168208B CN 105168208 B CN105168208 B CN 105168208B CN 201510372573 A CN201510372573 A CN 201510372573A CN 105168208 B CN105168208 B CN 105168208B
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Abstract
The invention discloses a kind of external drugs for bringing down a fever and bringing down a fever and preventing heatstroke and lower the temperature, it is matched according to parts by weight by following component raw material and is mixed, the parts by weight of each component raw material are as follows: 0.1-300 parts of menthol, 0.1-300 parts of borneol, 0.1-300 parts of paracetamol, 0.1-100 parts of chlorpheniramine, 0.1-100 parts of ethyl hydroxy benzoate, 1-500 parts of xanthan gum, 1-500 parts of guar gum, 2-1000 parts of ethyl alcohol, 2-1000 parts of glycerol, 0-1500 parts of purified water.The present invention is using Native Gel as carrier, it is primary raw material that Natural menthol, which cooperates with paracetamol, it is equipped with borneol, chlorpheniramine and some natural high molecular substances, with Transdermal absorption technique, keep effective ingredient infiltration subcutaneous, it is come out from body absorption heat toxin, achievees the effect that bring down a fever and bring down a fever and prevent heatstroke and lower the temperature.The present invention is applied to body meridian point by the way of smearing in vitro, and effective component is go the rounds with channels and collaterals, cooling effect of bringing down a fever is significant, and do not enter internal digestive system, it is the product brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever of a safety and environmental friendliness without any injury or toxic side effect.
Description
Technical field
The present invention relates to external drug technical fields, in particular to a kind of external drug for bringing down a fever and bringing down a fever and preventing heatstroke and lower the temperature.
Background technique
It is well known that there are many reason of causing fever, especially children fever treatment is got up more troublesome, due to children's torso
Physiogeny not fully, before not finding and causing to have a fever reason, cannot be treated using drug for abating fever, blindly simply
It is easy to cover the state of an illness using drug for abating fever, influences further treatment.Antipyretic is that one kind can be made by adjusting function of human body
Body surface blood vessel dilatation and then increase heat dissipation by the processes such as perspire, while the medicine for the body heat production reduction that inhibits to shiver with cold, make
Product.It can efficiently control fever, make hypothermia, but cannot release the reason of causing fever at all.
Antipyretic is in daily use, but its toxic side effect is also common.Such as drug rash, gastrointestinal reaction, hematological system reaction
And damage to hepatic and renal function etc., especially when using long or such drug being excessively used, toxic side effect is more significant.
The product of bringing down a fever commonly used in the prior art of bringing down a fever is oral antipyretic, oral antipyretic be by it is oral by drug into
Enter circulation in blood of human body, interfere human immune system, mandatory cooling is brought down a fever, and has injury to human body viscera.More and more
The lethal accident of medication demonstrates the fearful of hazards of medication.If patient is because virus infection causes to have a fever or body has inflammation
When, light, which only takes orally antipyretic, can not control the rebound of high temperature, and be unable to repeated drug taking in 4 hours after medication.
Drug of the present invention is in body surface medication, and without drug damages, it can be used repeatedly not by time restriction, if matching
It closes and uses anti-inflammatory drug, equally play the role of oral antipyretic, brought down a fever with external application mode and brought down a fever instead of oral way, to patient
Speech reduces a kind of drug damages.
Summary of the invention
Present invention aim to overcome above-mentioned the shortcomings of the prior art, provide one kind bring down a fever bring down a fever and sunstroke prevention drop
The external drug of temperature, is applied to the positions such as forehead, temple, SHENQUE acupoint, Yongquan acupoint, the treatment brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever
Effect is significant, repeated multiple times can smear, without side-effects.
To achieve the above object, technical solution provided by the invention is a kind of externally applied drug for bringing down a fever and bringing down a fever and preventing heatstroke and lower the temperature
Object, it is matched according to parts by weight by following component raw material and is mixed, and the parts by weight of each component raw material are as follows:
A kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever, it is characterised in that: it is by following component raw material according to weight
Number proportion mixes, and the parts by weight of each component raw material are as follows:
0.1-300 parts of menthol, 0.1-300 parts of borneol, 0.1-300 parts of paracetamol, 0.1-100 parts of chlorpheniramine, oxybenzene
0.1-100 parts of ethyl ester, 1-500 parts of xanthan gum, 1-500 parts of guar gum, 2-1000 parts of ethyl alcohol, 2-1000 parts of glycerol, purified water
0-1500 parts.
Preferably, which is matched according to parts by weight by following component raw material and is mixed, each component raw material
Parts by weight are as follows:
50-300 parts of menthol, 50-300 parts of borneol, 50-300 parts of paracetamol, 10-100 parts of chlorpheniramine, ethyl hydroxy benzoate
10-100 parts, 50-500 parts of xanthan gum, 50-500 parts of guar gum, 2-1000 parts of ethyl alcohol, 2-1000 parts of glycerol, purified water 0-
1500 parts.
Preferably, which is matched according to parts by weight by following component raw material and is mixed, each component raw material
Parts by weight are as follows:
50 parts of menthol, 50 parts of borneol, 100 parts of paracetamol, 10 parts of chlorpheniramine, 10 parts of ethyl hydroxy benzoate, 50 parts of xanthan gum,
50 parts of guar gum, 800 parts of ethyl alcohol, 50 parts of glycerol, 0-1500 parts of purified water.
Preferably, which is matched according to parts by weight by following component raw material and is mixed, each component raw material
Parts by weight are as follows:
50 parts of menthol, 100 parts of borneol, 50 parts of paracetamol, 20 parts of chlorpheniramine, 10 parts of ethyl hydroxy benzoate, xanthan gum 150
Part, 150 parts of guar gum, 1000 parts of ethyl alcohol, 50 parts of glycerol, 0-1500 parts of purified water.
Preferably, the dosage form of the external drug is patch.Patch is pasted on the skin, and drug can produce whole body or office
Portion's effect.Patch can be used for intact skin surface, it can also be used to have illness or incomplete skin surface.
Preferably, the dosage form of the external drug is gelling agent.
Preferably, the dosage form of the external drug is pearl agent.Bottle cap is opened, bottleneck is placed in forehead, too downward, by ball
It smears back and forth at the positions such as positive cave, SHENQUE acupoint, Yongquan acupoint.Each position repeated multiple times can smear, multiple positions while scribble effect
More preferably.
Preferably, the purified water is deionized water or distilled water.
Borneol inducing resuscitation of having one's ideas straightened out, heat-clearing dissipates poison, borneol transmucosal, subcutaneous tissue easily absorb, in vivo with glucuronic acid
In conjunction with heel row except external；The volatile dissipating wind-heat of menthol can be used for skin or mucous membrane and generate refrigerant sense to mitigate uncomfortable and pain,
Paracetamol antipyretic-antalgic, menthol and paracetamol are synergistic, dissipating wind-heat of volatilizing；Chlorpheniramine antiallergy and enhancing analgesia are made
With, borneol, menthol, paracetamol and chlorpheniramine synergistic effect, make to bring down a fever bring down a fever and the cooling effect prevented heatstroke and lower the temperature more preferably.It is yellow
Virgin rubber cooperates with the good molecule frame of framework with guar gum, and effective component is uniformly distributed in the carrier, keeps drug action uniform
Persistently, ethyl alcohol, glycerol, all ingredients of purified water reconciliation.
The beneficial effects of the present invention are: the present invention cooperates with paracetamol using Native Gel as carrier, with pure natural menthol
For primary raw material, being equipped with borneol, chlorpheniramine and some natural high molecular substances seeps effective ingredient with Transdermal absorption technique
It under transdermal, is come out from body absorption heat toxin, achievees the effect that bring down a fever and bring down a fever and prevent heatstroke and lower the temperature.Antipyretic gel is applied using external
The mode smeared, by being applied to body meridian point, effective component is go the rounds with channels and collaterals, and cooling effect of bringing down a fever is significant, and does not enter
Internal digestive system is that bringing down a fever for a safety and environmental friendliness brings down a fever and prevent heatstroke and lower the temperature without any injury or toxic side effect
Product.This product external application is applied to the positions such as forehead, temple, SHENQUE acupoint, Yongquan acupoint, significant in efficacy, without side-effects, can be repeatedly more
Secondary smearing.
Specific embodiment
The present invention is described in further detail combined with specific embodiments below.
Embodiment 1
A kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever, it matches mixing by following component raw material according to parts by weight
It forms, the parts by weight of each component raw material are as follows:
0.1 part of menthol, 0.1 part of borneol, 0.1 part of paracetamol, 0.1 part of chlorpheniramine, 0.1 part of ethyl hydroxy benzoate, xanthan gum 1
Part, 1 part of guar gum, 2 parts of ethyl alcohol, 2 parts of glycerol, 0 part of purified water.
Use the present embodiment that the dosage form of drug is made as patch.
Embodiment 2
A kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever, it matches mixing by following component raw material according to parts by weight
It forms, the parts by weight of each component raw material are as follows:
300 parts of menthol, 300 parts of borneol, 300 parts of paracetamol, 100 parts of chlorpheniramine, 100 parts of ethyl hydroxy benzoate, xanthan gum
500 parts, 500 parts of guar gum, 500 parts of ethyl alcohol, 100 parts of glycerol, 50 parts of purified water.
Use the present embodiment that the dosage form of drug is made as patch.
Embodiment 3
A kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever, it matches mixing by following component raw material according to parts by weight
It forms, the parts by weight of each component raw material are as follows:
50 parts of menthol, 50 parts of borneol, 100 parts of paracetamol, 10 parts of chlorpheniramine, 10 parts of ethyl hydroxy benzoate, 50 parts of xanthan gum,
50 parts of guar gum, 800 parts of ethyl alcohol, 50 parts of glycerol, 100 parts of purified water.
Use the present embodiment that the dosage form of drug is made as gelling agent.
Embodiment 4
A kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever, it matches mixing by following component raw material according to parts by weight
It forms, the parts by weight of each component raw material are as follows:
50 parts of menthol, 100 parts of borneol, 50 parts of paracetamol, 20 parts of chlorpheniramine, 10 parts of ethyl hydroxy benzoate, xanthan gum 150
Part, 150 parts of guar gum, 1000 parts of ethyl alcohol, 50 parts of glycerol, 100 parts of purified water.
Use the present embodiment that the dosage form of drug is made as pearl agent.
Embodiment 5
A kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever, it matches mixing by following component raw material according to parts by weight
It forms, the parts by weight of each component raw material are as follows:
50 parts of menthol, 50 parts of borneol, 50 parts of paracetamol, 30 parts of chlorpheniramine, 30 parts of ethyl hydroxy benzoate, 150 parts of xanthan gum,
150 parts of guar gum, 100 parts of ethyl alcohol, 100 parts of glycerol, 100 parts of purified water.
Use the present embodiment that the dosage form of drug is made as gelling agent.
Embodiment 6
A kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever, it matches mixing by following component raw material according to parts by weight
It forms, the parts by weight of each component raw material are as follows:
50 parts of menthol, 50 parts of borneol, 50 parts of paracetamol, 10 parts of chlorpheniramine, 10 parts of ethyl hydroxy benzoate, 75 parts of xanthan gum,
75 parts of guar gum, 500 parts of ethyl alcohol, 500 parts of glycerol, 1500 parts of purified water.
Use the present embodiment that the dosage form of drug is made as pearl agent.
Embodiment 7
A kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever, it matches mixing by following component raw material according to parts by weight
It forms, the parts by weight of each component raw material are as follows:
50 parts of menthol, 50 parts of borneol, 50 parts of paracetamol, 40 parts of chlorpheniramine, 40 parts of ethyl hydroxy benzoate, 100 parts of xanthan gum,
100 parts of guar gum, 800 parts of ethyl alcohol, 300 parts of glycerol, 1000 parts of purified water.
Use the present embodiment that the dosage form of drug is made as pearl agent.
Clinical test one:
It will bring down a fever and bring down a fever and external drug prevent heatstroke and lower the temperature and reducing temperature of heatstroke prevention is used to bring down a fever obtained by above-described embodiment 1
The clinical observation for the treatment of brought down a fever and prevented heatstroke and lower the temperature:
Selecting 100 fever body temperature is more than 38 DEG C of cases, wherein 48 people of male's case, 52 people of women case, by random point
Group method is divided into two groups, every group of 50 people.
Control group: according to the oral piece of bringing down a fever of operation instructions.
Experimental group: of the invention bringing down a fever is smeared according to operation instructions and is brought down a fever and external application prevent heatstroke and lower the temperature and reducing temperature of heatstroke prevention
Drug.
Drug effect is as follows: in patient, concrete result for the treatment
| Group | Number of cases | Temperature recovery after 3 minutes | Temperature recovery after ten minutes |
| Control group | 50 | 22 (44%) | 35 (70%) |
| Experimental group | 50 | 31 (62%) | 46 (92%) |
By table as it can be seen that therapeutic effect of the invention is significantly better than the curative effect for piece of bringing down a fever, difference is extremely significant.
Curative effect judging standard: temperature recovery rate after medication 3 minutes, medication temperature recovery rate after ten minutes.
The present invention does not add any essence and other substances, by the way of smearing in vitro, by being applied to body channels and collaterals
Acupuncture point, effective component are go the rounds with channels and collaterals, and cooling effect of bringing down a fever is significant, and do not enter internal digestive system, without any injury or poison
Side effect is the product brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever of a safety and environmental friendliness.
The above is a preferred embodiment of the present invention, but be not limited to that this.
Claims (1)
1. a kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever, which is characterized in that it is by following component raw material according to parts by weight
Number proportion mixes, and the parts by weight of each component raw material are as follows:
0.1 part of menthol, 0.1 part of borneol, 0.1 part of paracetamol, 0.1 part of chlorpheniramine, 0.1 part of ethyl hydroxy benzoate, 1 part of xanthan gum,
1 part of guar gum, 2 parts of ethyl alcohol, 2 parts of glycerol, 0 part of purified water, the dosage form of drug are patch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510372573.1A CN105168208B (en) | 2015-06-30 | 2015-06-30 | A kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510372573.1A CN105168208B (en) | 2015-06-30 | 2015-06-30 | A kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever |
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| Publication Number | Publication Date |
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| CN105168208A CN105168208A (en) | 2015-12-23 |
| CN105168208B true CN105168208B (en) | 2019-01-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510372573.1A Active CN105168208B (en) | 2015-06-30 | 2015-06-30 | A kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105616341A (en) * | 2016-03-08 | 2016-06-01 | 武汉烺祺生物科技有限公司 | Cold compress gel |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336960A (en) * | 2007-11-02 | 2009-01-07 | 徐宝恒 | Defervescence paste |
| CN103768142A (en) * | 2012-10-22 | 2014-05-07 | 孙莹 | Fever-reducing patch and preparation method thereof |
| CN104337796A (en) * | 2014-10-12 | 2015-02-11 | 浙江欧洁科技股份有限公司 | Polymeric hydrogel fever cooling patch for children and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199535A (en) * | 2006-12-15 | 2008-06-18 | 天津市中宝制药有限公司 | Patch for treating pediatrics febricide |
| CN102319142B (en) * | 2011-05-26 | 2013-07-10 | 谭波 | Antipyretic gel |
| CN103191185B (en) * | 2013-04-20 | 2013-12-18 | 江苏迪沃生物制品有限公司 | Antipyretic gel |
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2015
- 2015-06-30 CN CN201510372573.1A patent/CN105168208B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336960A (en) * | 2007-11-02 | 2009-01-07 | 徐宝恒 | Defervescence paste |
| CN103768142A (en) * | 2012-10-22 | 2014-05-07 | 孙莹 | Fever-reducing patch and preparation method thereof |
| CN104337796A (en) * | 2014-10-12 | 2015-02-11 | 浙江欧洁科技股份有限公司 | Polymeric hydrogel fever cooling patch for children and preparation method thereof |
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| CN105168208A (en) | 2015-12-23 |
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