CN103191185B - Antipyretic gel - Google Patents

Antipyretic gel Download PDF

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CN103191185B
CN103191185B CN 201310137722 CN201310137722A CN103191185B CN 103191185 B CN103191185 B CN 103191185B CN 201310137722 CN201310137722 CN 201310137722 CN 201310137722 A CN201310137722 A CN 201310137722A CN 103191185 B CN103191185 B CN 103191185B
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gel
fever
antipyretic
sodium
water
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CN103191185A (en
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贾峻峰
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江苏迪沃生物制品有限公司
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Abstract

本发明公开了一种退热凝胶,包括水溶性植物提取物、保湿剂及防腐剂。 The present invention discloses a fever gel comprising a water-soluble plant extracts, moisturizing agents and preservatives. 本发明退热凝胶能够用于儿童及成人各种原因引起的发热的物理退热,冷敷理疗及缓解肌肉酸痛及灼伤时的物理降温,尤其适用于夏季消暑及高温作业的降温,该退热凝胶清凉不具油性,使使用者感觉清爽舒服。 The present invention can be used in gel fever fever fever in children and adults a variety of physical causes, treatments and relieve physical cooling cold when muscle soreness and burns, especially for cool summer heat and high temperature operation of summer, the fever cool non-oily gel that enables users to feel fresh and comfortable.

Description

一种退热凝胶 One kind of fever gel

技术领域 FIELD

[0001] 本发明涉及医药技术领域,尤其涉及一种退热凝胶。 [0001] The present invention relates to the field of medical technology, more particularly to a fever gel.

背景技术 Background technique

[0002] 众所周知,引起发烧的原因很多,尤其是儿童发烧治疗起来更是麻烦,因儿童身体机能发育并不完全,在没有找到引起发烧的原因前,不能一味的使用退烧药物进行治疗,这样容易掩盖病情,影响进一步的治疗。 [0002] As we all know, causes a lot of fever, especially in the treatment of fever in children it is even more troublesome, because children's bodily functions are not fully developed, before the cause of the fever is not found, can not blindly use of anti-fever medicines, so easy cover up the disease, affecting further treatment. 因此,目前发烧38.5°C以下提倡的是采用物理降温方式退烧。 Therefore, the current fever 38.5 ° C or less is employed to promote physical cooling mode fever. 现有技术中临床上常用的具备物理冷疗、退热的产品为退热贴或退热粘胶。 The prior art includes a physical common cold therapy clinical products for fever or fever cooling paste adhesive. 但在临床使用中发现退热贴或退热粘胶的物理退热持续时间短,油腻不清爽,成分分布不均。 But found physical fever fever cooling paste adhesives or short duration, not fresh greasy, non-uniform composition distribution in clinical use. 天气干燥时,用后皮肤易脱水,不舒服。 When the weather is dry, dehydrated skin after use is easy, uncomfortable. 因为目前临床及药店所售产品常用甘油作为吸水保湿及润滑基质,甘油具有较强的吸湿性,能从空气中吸取水分,当空气干燥时,空气中水分子很少,甘油反而从人体皮肤直接汲取水分,特别是冬季及干燥地区特别明显。 Because of the current clinical and pharmacy products commonly sold as glycerin moisturizing and lubricating absorbent substrates, glycerol has a strong hygroscopic, absorb moisture from the air, when the air is dry, the water molecules in the air very little, but glycerol directly from human skin draw water, especially in winter and is particularly evident in dry areas. 这样就使因高温发烧本身就缺水的皮肤更加干燥,影响甘油的保湿性,制剂的持续退热时间变短,导致发热反弹。 This allows high temperature due to fever itself is dry skin more dry, moisturizing glycerin impact of sustained fever preparation time is shortened, resulting in fever rebound. 更重要的是,科学证明含甘油的制品易滋长流感病毒,特别是禽流感病毒。 More importantly, scientifically proven products containing glycerin easy to grow influenza virus, especially avian influenza virus. 国家卫生和计划生育委员会公布:禽流感病毒在有甘油存在的情况下可保持活力I年以上。 National Health and Family Planning Commission announced: avian influenza virus in the presence of glycerol can remain viable over I years. 而传统的物理退热产品退热贴和退热粘胶均含有大量的甘油成份,使用这些产品时,由于甘油的上述特性,易造成感冒病毒不被杀灭,出现反复感染或传染他人,延误感冒治疗。 The traditional physical products fever fever cooling paste and adhesives contain a large part of glycerin, when using these products, due to the above-mentioned properties of glycerol, could easily lead to a cold virus is not killed, appeared recurrent infections or infecting others, delays cold treatment. 另外薄荷脑和甘油的油腻性,使人用后感觉油腻不清爽,不舒服。 In addition greasy menthol and glycerin, people feel fresh and not greasy and uncomfortable after use.

[0003] 薄荷主要含荨荷脑、薄荷酮等挥发油成分。 [0003] Qian charge brain predominantly contains mint, menthol and other volatile oil components. 我国中医上认为薄荷“性凉味辛,有宣散风热、淸头目、透疹之功”,认为其具有兴奋大脑、促进血液循环、发汗,与消炎鎭痛、止痒解毒和疏散风热的作用。 Mint think "cool spicy, declared scattered wind-heat, Qing leader, Touzhen of power" that it has excited brain, promote blood circulation, sweating, pain and anti-inflammatory Zhen, itching detoxification and evacuation of wind-heat on Chinese medicine in China role. 西医研究认为薄荷的药理作用主要有:1、局部作用:薄荷水局部应用有清凉、止痒、消炎、止痛的功效。 Western medicine studies suggest that the pharmacological effects of menthol are: 1, the local effects: topical application of a cool mint water, anti-itch, anti-inflammatory, analgesic effect. 薄荷醇能刺激皮肤神经末梢感受器,先产生凉的感觉,继而有轻微的灼热感。 Menthol stimulates the nerve endings in the skin receptors, to produce cool feeling, then a slight burning sensation. 缓慢地透人皮内,引起长时间的充血,而达到治疗作用。 Slowly people through intradermal, caused by a long period of congestion, to achieve a therapeutic effect. 2、解热:小量薄荷能兴奋中枢神经,使周围毛细血管扩张而散热;并促进汗腺分泌而发汗。 2, antipyretic: mint small central nervous system excitement, so that the surrounding heat telangiectasia; and promote the secretion of sweat glands. 因此有降低体温的作用。 Therefore reducing the role of body temperature. 3、抗炎:薄荷所含的8种儿茶萘酚酸是有效的抗炎剂,能抑制3a—羟类固醇脱氢酶而有弱自:抗炎作用。 3, anti-inflammatory: 8 kinds naphthyl protocatechuic acid contained menthol are effective anti-inflammatory agent, can be suppressed 3a- hydroxysteroid dehydrogenase while weak from: anti-inflammatory effect. 薄荷所含的蓝香油烃对烫伤兔耳有抗炎作用。 Mint oil hydrocarbons contained in the blue scalded rabbit ear anti-inflammatory effect. 本发明利用上述西医研究理论中起物理降温的作用部分,加入水溶性薄荷提取物。 The present invention utilizes the above-described acting portion in Western medicine Theoretical Physics from cooling, adding water-soluble extract of mint.

[0004] 由于薄荷具有的药理作用,现有技术中的用于退热的凝胶剂或软膏,多利用冰片、薄荷或薄荷脑或薄荷油或其它薄荷提取物作为主要退热药物来进行人体外用散热退热。 [0004] Due to the pharmacological effects of menthol having, gels or ointments for fever in the prior art, the use of multi-borneol, peppermint or menthol or peppermint oil or other mint extract as an antipyretic drugs to main body external cooling fever. 申请号为200710202363的中国专利公开了一种退热膏,该退热膏由薄荷、冰片、乙醇、甘油按一定比例配比而成。 Of Chinese Application No. 200710202363 discloses a fever paste, which paste is a fever mint, borneol, ethanol, glycerol ratio certain proportion. 申请号为201110138429.3的中国专利公开了一种退热凝胶,该退热凝胶由原料:卡波姆、丙二醇、氨水、对羟基苯甲酸乙酯、薄荷脑、冰片、乙醇和水按一定比例搅拌混合而成凝胶状。 Of Chinese Application No. 201110138429.3 discloses a fever gel, which gel by the antipyretic ingredients: carbomer, propylene glycol, ammonia, ethyl p-hydroxybenzoate, menthol, borneol, a certain proportion of ethanol and water mixed gel was stirred.

[0005] 而水溶性薄荷油不同于以往药用中的薄荷脑等薄荷提取物,水溶性薄荷油在用于退热凝胶或退热露中,能在退热凝胶或退热露的感官细腻、外观透明、品质稳定性等方面具有独特的促进增效协同功能的作用。 [0005] Unlike conventional pharmaceutically acceptable and water-soluble peppermint menthol in peppermint extract, peppermint oil in a water-soluble or fever dew fever gel, the gel can be exposed to fever or antipyretic sensory fine, transparent appearance, quality and stability aspects of a unique synergy promoting efficiency function. 并且不同于薄荷油,水溶性薄荷油无需另加助溶剂,即可直接溶于水中,呈均匀透明状态,感觉柔顺平滑。 And is different from peppermint oil, spearmint oil without the addition of a water-soluble co-solvent, can be directly dissolved in water, showed a uniform transparent state, it has a smooth feeling. 目前退热用的退热膏、退热凝胶或退热露中未见有用水溶性薄荷油。 Currently antipyretic cream with fever, fever and no gel or gels useful in fever peppermint oil soluble.

[0006] 透明质酸钠是透明质酸的钠盐形式。 [0006] sodium hyaluronate are hyaluronic acid sodium salt. 透明质酸为一种酸性粘多糖,透明质酸以其独特的分子结构和理化性质在机体内显示出多种重要的生理功能,如润滑关节,调节血管壁的通透性,调节蛋白质,水电解质扩散及运转,促进创伤愈合等。 Hyaluronic acid is an acid mucopolysaccharide, hyaluronic its unique molecular structure and physicochemical properties are shown in the body of a variety of important physiological functions such as lubricating joints, regulate the permeability of the vessel wall, regulatory proteins, water electrolyte diffusion and operation, and promote wound healing. 尤为重要的是,透明质酸具有特殊的保水作用,是目前发现的自然界中保湿性最好的物质,被称为理想的天然保湿因子(Natural moisturizing factor, NMF)。 More importantly, the hyaluronic acid has a special water retention, is currently found in nature in the best moisturizing substances, referred to as an ideal natural moisturizing factor (Natural moisturizing factor, NMF). 但透明质酸钠多用于化妆品的保湿作用,未见有用于退热凝胶、退热膏或退热露中的报道。 However, sodium hyaluronate used for moisturizing cosmetics, there are no reports fever gel, paste or fever antipyretic gel is used.

[0007] 综上所述,在现有的用于退热的外用制剂中未见有利用水溶性薄荷油、透明质酸钠配合来进行退热。 [0007] As described above, the conventional topical formulations have not been used as an antipyretic in the use of water-soluble oil, sodium hyaluronate is performed with fever.

发明内容 SUMMARY

[0008] 为了克服现有技术中的退热贴或退热凝胶物理退热持续时间短,油腻不清爽,且干燥天气下使用皮肤易脱水等技术缺陷,本发明提供一种退热凝胶,旨在用于儿童及成人各种原因引起的发热的物理退热,冷敷理疗及缓解肌肉酸痛及灼伤时的物理降温,尤其适用于夏季消暑及高温作业的降温,退热制剂清凉不具油性,使使用者感觉清爽舒服。 [0008] In order to overcome the prior art cooling paste or gel fever physical fever short duration, not greasy refreshing, and dried under weather prone skin dehydration using technical defects, the present invention provides a gel antipyretic intended for physical fever fever in children and adults a variety of causes, treatments and relieve physical cooling cold when muscle soreness and burns, especially for summer cool and refreshing hot work, antipyretic agents refreshing non-oily, so that users feel comfortable and fresh.

[0009] 为实现上述目的,本发明采用的技术方案是:一种退热凝胶,包括水溶性植物提取物、保湿剂和防腐剂。 [0009] To achieve the above object, the present invention adopts the technical solution is: A fever gel comprising a water-soluble plant extracts, humectants and preservatives.

[0010] 优选的,所述水溶性植物提取物包括水溶性薄荷、水溶性薄荷油、水溶性薄荷脑、荷叶提取物中的至少一种。 [0010] Preferably, the water-soluble plant extract comprising a water-soluble menthol, peppermint oil soluble, menthol-soluble, at least one lotus leaf extract.

[0011] 优选的,所述保湿剂包括透明质酸钠、黄原胶、海藻酸钠、卡波姆中的至少一种;所述防腐剂包括对氨基苯甲酸钠、羟苯乙酯、对羟基苯甲酸酯钠、尼泊金复合酯钠、苯扎氯铵中的至少一种。 [0011] Preferably, the humectant comprises at least one sodium hyaluronate, xanthan gum, sodium alginate, carbomer; said amino preservatives include sodium benzoate, ethylparaben, hydroxy ester sodium benzoate, sodium acetate Nipagin composite, benzalkonium chloride, at least one.

[0012] 优选的,所述退热凝胶包括水溶性薄荷油、保湿剂、对氨基苯甲酸钠;所述保湿剂为透明质酸钠、黄原胶中的一种或两种。 [0012] Preferably, the gel comprises a water-soluble peppermint fever, humectants, sodium p-aminobenzoic acid; the humectant is sodium hyaluronate, xanthan gum or both.

[0013] 本发明所述的水溶性薄荷油是利用超微乳化直溶技术,采用亲水性极强的w-sp系列高效直溶剂,将不溶于水的薄荷油改性为可与水之间形成配位、复合、水合等动态缔合性的稳定水合物,又称层状透明晶液。 [0013] The water-soluble peppermint present invention utilizes ultra straight soluble emulsification technology, a hydrophilic highly efficient linear w-sp series solvents, water-insoluble modified to be peppermint oil and water formed between the ligand, complex, and other dynamic hydration associative stable hydrate, also known as liquid crystalline layered transparent. 不仅可达到直溶于水的目的,还能提高水基产品本身的使用效果、生物化学性能。 Not only can achieve the purpose of water-soluble linear, but also increase the water-based product itself results, biochemical properties. 水溶性薄荷油在退热凝胶或退热露产品的感官细腻、外观透明,品质稳定性等方面具有独特的促进增效协同功能的作用。 Peppermint oil in the water-soluble gel or fever fever sensory exposed delicate products, transparent appearance, quality and stability aspects of a unique synergistic effect of promoting collaboration capabilities. 水溶性薄荷油无需另加助溶剂,即可直接溶于水中,呈均匀透明状态,感觉柔顺平滑。 Peppermint oil soluble without the addition of a co-solvent, can be directly dissolved in water, showed a uniform transparent state, has a smooth feeling. 本发明所用的水溶性薄荷油采用的是由上海市新嘉香料有限公司生产的水溶性薄荷油。 Soluble peppermint oil used in the present invention are employed from the Shanghai New Co Ka soluble peppermint flavor. 本发明所述的水溶性薄荷油可以按照《水溶性薄荷油的制备》(于西全,黄立峰,康鲁平,《中国医院药学杂志》1999年10期)中所述的制备方法制备。 Water-soluble peppermint oil in accordance with the present invention may be "preparing water-soluble peppermint oil" was prepared in the preparation method (in the whole West, Huang Lifeng, Kanglu Ping, 1999 10 "Chinese Journal of Hospital Pharmacy").

[0014] 由于退热凝胶或退热露是皮肤外用产品,不参与人体微循环,不伤肝肾,持续物理降温,保护大脑,是儿童基金组织首推的物理退热方式,本发明中所述的退热凝胶还可制成退热露。 [0014] Since the gel fever or fever exposed skin is topical products, not involved in micro-circulation, not to hurt the liver and kidney, sustained physical cooling, protect the brain, is the most important physical Children's Fund fever, the present invention the gel may also be made of the fever antipyretic exposed.

[0015] 上述本发明退热凝胶中,起到退热效果的核心药物是水溶性薄荷油,透明质酸钠以其优良的保湿性作为保湿剂。 Drug Core [0015] fever gel of the present invention, are water-soluble play antipyretic effect peppermint oil, sodium hyaluronate its excellent moisturizing properties as a humectant. 本发明所述的黄原胶是一种由假黄单孢菌发酵产生的单孢多糖,由于它的大分子特殊性、结构和胶体特性,而具有多种功能,集乳化、悬浮、增稠、保湿、浸润等于一体,仿生润滑,性能优越。 The present invention is xanthan gum Micromonospora a polysaccharide produced by Xanthomonas fermentation prosthesis, due to its macromolecular specificity, the structure and properties of colloids, having a variety of functions, set emulsifying, suspending, thickening , moisture infiltration is one, bionic lubrication, superior performance. 黄原胶水溶性好,能和水溶性薄荷油相互协同、溶解,均匀分布溶剂中,易于涂抹,并且由于黄原胶本身具备的增稠特性,使得本发明中无须再加入各种增稠剂,而使得溶液本身具备一定粘性,能使本发明中的水溶性薄荷油、透明质酸钠、乙醇很好的持久分布,均匀发挥功效,对人体无刺激,无毒性。 Xanthan gum good water solubility, can cooperate with each other and a water-soluble peppermint oil, dissolved, distributed uniformly in the solvent, easy to apply, and since the thickening properties of xanthan gum itself has, so that the present invention without further addition of various thickeners , so that the solution itself has a certain viscosity, water soluble make peppermint oil in the present invention, sodium hyaluronate, ethanol lasting good distribution of uniformly effective, non-irritating to humans, non-toxic.

[0016] 但由于透明质酸钠原料价格较贵,而黄原胶具备透明质酸钠在本发明中的同样性能,可完全替代或与透明质酸钠互补协同作用。 [0016] However, due to more expensive raw materials, sodium hyaluronate, xanthan gum and sodium hyaluronate have the same performance in the present invention, can completely replace sodium hyaluronate or with complementary and synergistic effect. 两者都有很好的浸润性、保湿性、水溶性等共性,能相互有机结合,协同发挥作用。 Both have good wettability, moisture, and other common water-soluble, can mutually combine, synergistically.

[0017] 本发明中所述的对氨基苯甲酸钠,级别:BR,是上海信然生化试剂有限公司生产的。 [0017] The present invention is sodium benzoate amino, Level: BR, then the letter is Shanghai Biochemicals Limited production.

[0018] 优选的,上述退热凝胶按质量百分数包括:0.001 % -8%的水溶性薄荷油,0.0001% -3%的透明质酸钠,0.01 % -3%的对氨基苯甲酸钠;所述退热凝胶的pH值在4.0-8.0之间。 [0018] Preferably, in the mass percentage, fever gel comprising: from 0.001% to 8% of a water soluble oil, 0.0001% to 3% sodium hyaluronate, 0.01% -3% of sodium p-aminobenzoic acid; by antipyretic pH of said gel is between 4.0-8.0. 进一步优选的,所述退热凝胶按质量百分数包括:0.1%-5 %的水溶性薄荷油,0.05%-1%的透明质酸钠,0.1%-1 %的对氨基苯甲酸钠;所述退热凝胶的pH值在5.0-6.5之间。 Further preferably, the gel mass percentage, fever comprising: 0.1% to 5% of a water soluble oil, 0.05% to 1% of sodium hyaluronate, 0.1% to 1% of sodium p-aminobenzoic acid; the antipyretic pH of the gel is between 5.0-6.5.

[0019] 优选的,上述退热凝胶按质量百分数包括:0.001 % -8%的水溶性薄荷油,0.01% -7%的黄原胶,0.01 % -3%的对氨基苯甲酸钠;所述退热凝胶的pH值在4.0-8.0之间;进一步优选的,所述退热凝胶按质量百分数包括:0.1%-5 %的水溶性薄荷油,0.5%-4 %的黄原胶,0.1%-1 %的对氨基苯甲酸钠;所述退热凝胶的pH值在5.0-6.5之间。 [0019] Preferably, in the mass percentage, fever gel comprising: from 0.001% to 8% of a water soluble oil, from 0.01% to 7% of xanthan gum, from 0.01% to 3% sodium p-aminobenzoic acid; the antipyretic pH of the gel is between 4.0 and 8.0; more preferably, the mass percentage, fever gel comprising: 0.1% to 5% of a water-soluble peppermint oil, 0.5% to 4% xanthan gum, 0.1% to 1% of sodium p-aminobenzoic acid; antipyretic the gel pH value between 5.0-6.5.

[0020] 本发明所述的退热凝胶的pH值可采用稀盐酸进行调节。 [0020] pH value of the gel antipyretic present invention may be adjusted with dilute hydrochloric acid.

[0021] 本发明中上述退热凝胶还包括质量百分数为3 % -30%的乙醇,优选的,所述乙醇的质量百分数为5%-20 %。 [0021] The present invention further includes the aforementioned gel antipyretic mass percentage of 3% to 30% ethanol, mass Preferably, the ethanol percentage is 5% -20%.

[0022] 本发明中所述的乙醇,在传统配方中是一种溶剂。 [0022] In the present invention, ethanol, in the conventional formulation is a solvent. 因为薄荷脑、薄荷油等不溶于水,极易溶于乙醇中,所以临床上的物理退热贴、退热粘胶等中都要加入乙醇来溶解薄荷脑、薄荷油等不溶于水的组分。 Since menthol, peppermint oil insoluble in water, easily soluble in ethanol, the physical antipyretic clinical stickers, adhesives and the like have fever ethanol was added to dissolve menthol, peppermint oil and other water-insoluble groups Minute. 本发明中的水溶性薄荷油能很好的溶于水中,不需另加乙醇等溶解剂。 Peppermint oil soluble in the present invention can be well dissolved in water, ethanol and the like without additional dissolving agent. 但由于乙醇具有良好的渗透及挥发性,所以本发明中可加入适量乙醇,以增加产品的物理退热性。 However, since ethanol has a good penetration and volatile, so that the present invention may be added an appropriate amount of ethanol to increase the product's physical fever.

[0023] 本发明所述退热凝胶的粘度在1-200 mpa.s之间。 [0023] The viscosity of the gel of the present invention antipyretic between 1-200 mpa.s.

[0024] 进一步的,所述退热凝胶的粘度在20-100 mpa.s之间。 [0024] Further, the viscosity of the gel antipyretic between 20-100 mpa.s.

[0025] 本发明的上述退热凝胶还可制成退热露,以方便使用。 [0025] The gel of the present invention may also antipyretic fever dew formed, for ease of use.

[0026] 本发明中所述的水溶性薄荷油与黄原胶或透明质酸钠配合,因黄原胶的悬浮性、浸润性、水溶性、保湿性、凝胶增稠及透明质酸钠优良的保湿、浸润及水溶性,能使水溶性薄荷油持久、均匀的发挥渗透及挥发功能,且能够克服较低温度条件下水溶性薄荷油不凝固的特点,较添加其它化学辅料,更安全、无刺激、无副作用。 [0026] The present invention is a water-soluble mint oil and xanthan gum or sodium hyaluronate complexes, because of the suspension of xanthan gum, wettability, water-soluble, moisture retention, thickening and sodium hyaluronate gel excellent moisturizing, infiltration and water-soluble, water-soluble peppermint can lasting, uniform permeation and volatilization of play features, a water-soluble and capable of overcoming the relatively low temperature without peppermint solidification characteristics, than add other chemical materials, safer, no stimulation, no side effects. 即本发明中的黄原胶与透明质酸钠可择一使用,也可两者皆用。 I.e. xanthan gum and sodium hyaluronate in the present invention may be alternatively used, both of which are also used.

[0027] 本发明的退热凝胶是由水溶性薄荷油、透明质酸钠和/或黄原胶、对氨基甲酸酯钠、乙醇,用纯化水混合搅拌均匀而成的一种物理降温、冷疗的一种产品。 [0027] fever gel of the invention is a water-soluble oil, sodium hyaluronate and / or xanthan gum, sodium carbamate, ethanol, stirred and mixed with purified water obtained by uniformly cooling a kind of physical , a cold therapy products. 具有退热快、退热时间持续长、安全舒适、无油腻不适感、清凉爽快等优点。 Has a fever fast, fever lasted long, safe and comfortable, non-greasy discomfort, cool, refreshing and so on.

[0028] 本发明的有益效果是:本发明退热凝胶退热快、退热持续时间长且清爽凉快,使用者无油腻不适感。 [0028] Advantageous effects of the present invention are: fever fast cooling gel of the present invention, a long duration of fever and a refreshing cool, non-greasy user discomfort. 具体实施方式 Detailed ways

[0029] 下面对本发明的较佳实施例进行详细阐述,以使本发明的优点和特征能更易于被本领域技术人员理解,从而对本发明的保护范围做出更为清楚明确的界定。 [0029] The following preferred embodiments of the present invention will be described in detail, so that the advantages and features of the present invention can be more readily understood by those skilled in the art, in order to make more clearly the scope of clearly defined in the present invention.

[0030] 实施例1:一种退热凝胶:取水溶性薄荷油0.lg、透明质酸钠lg、对氨基苯甲酸钠0.lg,将各组分搅拌均匀,用稀盐酸调节pH值至5.0,加入纯化水至100g,将各组分混合均匀。 [0030] Example 1: A gel fever: Take a water-soluble peppermint 0.lg, sodium hyaluronate lg, p-aminobenzoic acid, sodium 0.lg, stir the components, the pH is adjusted with dilute hydrochloric acid to 5.0, purified water was added to 100g, the components are mixed.

[0031] 实施例2:—种退热凝胶:取水溶性薄荷油2g、透明质酸钠0.lg、对氨基苯甲酸钠0.lg,医用乙醇8 g将各组分搅拌均匀,用稀盐酸调节pH值至6.0,加入纯化水至IOOgdf各组分混合均匀。 [0031] Example 2: - fever gel Species: Take a water-soluble peppermint 2g, sodium hyaluronate 0.lg, p-aminobenzoic acid, sodium 0.lg, 8 g ethanol medical Stir the components, with dilute hydrochloric acid pH is adjusted to 6.0, purified water was added to the components mixed IOOgdf.

[0032] 实施例3: —种退热凝胶,每IOOg含:水溶性薄荷油2g、透明质酸钠0.lg、黄原胶3g、对氨基甲酸酯钠0.3g、医用乙醇Sg。 [0032] Example 3: - fever gel types, each containing IOOg: spearmint oil soluble 2g, sodium hyaluronate 0.lg, xanthan gum 3g, sodium carbamate 0.3g, medical ethanol Sg. 其制备方法参见实施例1。 The preparation method see Example 1.

[0033] 实施例4:一种退热凝胶,每IOOg含:水溶性薄荷油Ig、透明质酸钠0.7g、黄原胶lg、对氨基甲酸酯钠0.2g、医用乙醇10g。 [0033] Example 4: one kind fever gel IOOg each containing: an Ig soluble peppermint oil, sodium hyaluronate 0.7g, xanthan gum lg, sodium carbamate 0.2g, medical ethanol 10g. 其制备方法参见实施例1。 The preparation method see Example 1.

[0034] 实施例5:—种退热凝胶,每IOOg含:水溶性薄荷油4 g、透明质酸钠0.4g、黄原胶2g、对氨基甲酸酯钠0.4 g、医用乙醇15g。 [0034] Example 5: - fever gel types, each IOOg comprising: a water-soluble mint oil 4 g, sodium hyaluronate 0.4g, xanthan gum 2g, sodium carbamate 0.4 g, 15g ethanol medical pair. 其制备方法参见实施例1。 The preparation method see Example 1.

[0035] 实施例6:—种退热凝胶,每IOOg含:水溶性薄荷油3g、透明质酸钠lg、黄原胶 [0035] Example 6: - fever gel types, each IOOg comprising: a water-soluble peppermint 3g, sodium hyaluronate lg, xanthan gum

0.5 g、对氨基甲酸酯钠0.5g、医用乙醇18g。 0.5 g, sodium carbamate 0.5g, medical ethanol 18g. 其制备方法参见实施例1。 The preparation method see Example 1.

[0036] 实施例7:—种退热凝胶:取水溶性薄荷油5g、透明质酸钠0.05g、对氨基苯甲酸钠 [0036] Example 7: - fever gel Species: Take a water-soluble peppermint 5g, sodium hyaluronate 0.05g, p-aminobenzoic acid, sodium

0.lg,用稀盐酸调节pH值至6.0,加入纯化水至100g,将各组分混合搅拌均匀即得。 0.lg, adjusted with dilute hydrochloric acid to pH 6.0, was added purified water to 100g, mixing the components to obtain uniform mixing.

[0037] 实施例8:一种退热凝胶,其按质量百分数包括:3%的水溶性薄荷油,0.5%的透明质酸钠及0.5%的对氨基苯甲酸钠。 [0037] Example 8: one kind fever gel, which comprises, in mass percentage: 3% water soluble peppermint oil, 0.5% of sodium hyaluronate and 0.5% of sodium p-aminobenzoic acid. 该退热凝胶的制备可参照上述实施例,依常规调整工艺处方制得。 The gel may be prepared fever embodiments with reference to the above-described embodiments, the adjustment process recipe obtained by the conventional system.

[0038] 实施例9:一种退热凝胶,其按质量百分数包括:8%的水溶性薄荷油,3%的透明质酸钠、3%的对氨基苯甲酸钠、15%的乙醇。 [0038] Example 9: fever one kind of gel, comprising, in mass percent: 8% of a water soluble oil, 3% of sodium hyaluronate, 3% of sodium amide acid, 15% ethanol. 该退热凝胶的制备可参照上述实例,依常规调整工艺处方制得。 The gel may be prepared fever reference to the example, the adjustment process recipe obtained by the conventional system.

[0039] 实施例10:—种退热露,其按质量百分数包括:8%的水溶性薄荷油,7%的黄原胶、3%的对氨基苯甲酸钠。 [0039] Example 10: - fever exposed species, comprising, in mass percent: 8% water soluble peppermint oil, 7% xanthan gum, 3% of sodium p-aminobenzoic acid.

[0040] 实施例11:一种退热凝胶,其按质量百分数包括:5%的水溶性薄荷油,7%的黄原胶、3%的对氨基苯甲酸钠、20%的乙醇。 Antipyretic one kind of gel, comprising, in mass percent:: 5% soluble oil, 7% xanthan gum, 3% of sodium benzoate amino, ethanol 20% [0040] Example 11. 该退热凝胶可参照上述实例,依常规调整工艺处方制得。 The gel can be referred to the above example fever, adjustments made by the conventional process recipe.

[0041 ] 实施例12: —种退热凝胶,其按质量百分数包括:0.1%的水溶性薄荷油,4%的黄原胶、0.1%的对氨基苯甲酸钠、5%的乙醇。 [0041] Example 12: - fever gel species, comprising, in mass percent: 0.1% water soluble peppermint oil, 4% xanthan gum, 0.1% of p-aminobenzoic acid, sodium, 5% ethanol. 该退热凝胶可参照上述实例,依常规调整工艺处方制得。 The gel can be referred to the above example fever, adjustments made by the conventional process recipe.

[0042] 实施例13: —种退热凝胶,其按质量百分数包括:0.1%的水溶性薄荷油,0.5%的黄原胶、1%的对氨基苯甲酸钠。 [0042] Example 13: - fever gel species, comprising, in mass percent: 0.1% water soluble peppermint oil, 0.5% xanthan gum, 1% of sodium p-aminobenzoic acid. 该退热凝胶可参照上述实例,依常规调整工艺处方制得。 The gel can be referred to the above example fever, adjustments made by the conventional process recipe.

[0043] 实施例14:一种退热凝胶,其按质量百分数包括:1%的水溶性薄荷油、0.8%的透明质酸钠、0.2%的对氨基苯甲酸钠、10%的乙醇。 Antipyretic one kind of gel, comprising, in mass percent:: 1% water soluble peppermint oil, 0.8% sodium hyaluronate, 0.2% of p-aminobenzoic sodium benzoate, 10% ethanol [0043] Example 14.

[0044] 以制备IOOg该退热凝胶为例,取水溶性薄荷油I g、透明质酸钠0.Sg、对氨基甲酸酯钠0.2 g、乙醇10 g,加入纯化水并用稀盐酸调节pH值至6.5,定量至100g,将各组分混合搅拌均匀即得。 [0044] In the preparation IOOg fever gel, for example, peppermint oil soluble take I g, sodium hyaluronate 0.Sg, sodium carbamate 0.2 g, ethanol 10 g, purified water was added and the pH was adjusted with dilute hydrochloric acid value to 6.5, to quantitatively 100g, mixing the components to obtain uniform mixing.

[0045] 实施例15:—种退热凝胶,其按质量百分数包括:4%的水溶性薄荷油、0.4%的透明质酸钠、0.6%的对氨基苯甲酸钠、15%的乙醇。 Species fever gel, which comprises, in mass percentage: 4% water soluble peppermint oil, 0.4% of sodium hyaluronate, 0.6% of p-aminobenzoic acid, sodium, 15% - ethanol: [0045] Example 15.

[0046] 以制备IOOg该退热凝胶为例,取水溶性薄荷油4 g、透明质酸钠0.4g、对氨基甲酸酯钠0.6g、乙醇15 g,加入纯化水并用稀盐酸调节pH值至6.5,将各组分混合搅拌均匀即得。 [0046] In the preparation IOOg fever gel, for example, peppermint oil soluble taking 4 g, sodium hyaluronate 0.4g, sodium carbamate 0.6g, ethanol 15 g, purified water was added and pH was adjusted with dilute hydrochloric acid to 6.5, mixing the components to obtain uniform mixing.

[0047] 实施例16: —种退热凝胶,其按质量百分数包括:6%的水溶性薄荷油、0.4%的黄原胶、1.6%的对氨基苯甲酸钠、15%的乙醇。 [0047] Example 16: - fever species gel, which comprises, in mass percentage: 6% water soluble peppermint oil, 0.4% xanthan gum, 1.6% of p-aminobenzoic sodium benzoate, 15% ethanol.

[0048] 以制备IOOg该退热凝胶为例,取水溶性薄荷油4 g、黄原胶0.4g、对氨基甲酸酯钠1.6g、乙醇15 g,加入纯化水,并调节pH值至6.0,定量至IOOg,将各组分混合搅拌均勻即得。 [0048] In the preparation IOOg fever gel, for example, peppermint oil soluble taking 4 g, xanthan gum 0.4g, sodium carbamate 1.6g, ethanol 15 g, was added purified water, and adjusted to pH 6.0 quantitatively to IOOg, mixing the components to obtain uniform mixing.

[0049] 实施例17: —种退热凝胶,其按质量百分数包括:3%的水溶性薄荷油、0.5%的黄原胶、0.5%的对氨基苯甲酸钠、18%的乙醇。 [0049] Example 17: - fever species gel, which comprises, in mass percentage: 3% water soluble peppermint oil, 0.5% xanthan gum, 0.5% of p-aminobenzoic sodium benzoate, 18% ethanol.

[0050] 实施例18:—种退热凝胶,其按质量百分数包括:2.5%的水溶性薄荷油、1%的透明质酸钠、0.5%的对氨基苯甲酸钠、12%的乙醇。 [0050] Example 18: - fever gel species, comprising, in mass percent: 2.5% water soluble peppermint oil, 1% sodium hyaluronate, 0.5% of p-aminobenzoic sodium benzoate, 12% ethanol.

[0051] 以制备IOOg该退热凝胶为例,取水溶性薄荷油2.5g、透明质酸钠I g、对氨基甲酸酯钠0.5g、乙醇18g,加入纯化水,并调节pH值至6.0,定量至IOOg,将各组分混合搅拌均匀即得。 [0051] In the preparation IOOg fever gel, for example, peppermint oil soluble take 2.5g, sodium hyaluronate I g, sodium carbamate 0.5g, ethanol, 18g, was added purified water, and adjusted to pH 6.0 quantitatively to IOOg, mixing the components to obtain uniform mixing.

[0052] 对照实施例1 一种退热凝胶,每IOOg含:薄荷脑2g、透明质酸钠0.lg、黄原胶3g、对氨基甲酸酯钠0.3g 、医用乙醇Sg。 [0052] Control Example 1 A gel fever embodiment, each IOOg contains: menthol 2g, sodium hyaluronate 0.lg, xanthan gum 3g, sodium carbamate 0.3g, medical ethanol Sg. 其制备方法参见实施例1。 The preparation method see Example 1.

[0053] 本发明为局部外用,使用时,可将本发明的退热凝胶直接涂抹于患者额头、太阳穴、大椎穴、腋窝、胭窝、大腿和小腿内侧等部位的皮肤表面,利用凝胶挥发散热的原理,对局部降温来实行辅助退热;与现有退热贴技术相比,本发明的退热凝胶,退热有效率高、降温效果显著。 [0053] The present invention is a topical, when in use, the present invention fever gel applied directly to the patient's forehead, temple portion of the skin surface, Dazhui, axillary, popliteal, like the inner thigh and calf, by gel volatile cooling principle, the local cooling to the assisting fever; fever as compared with the prior art paste, gel fever present invention, high efficiency fever, significant cooling effect. 或者,作为本发明的另一种外用制剂方式,制成退热露后,还可以分装到涂抹走珠瓶内,每瓶30-70g。 Alternatively, as another embodiment of the present invention, the external preparation, the gel formed fever, can also be dispensed to the applicator roll-on bottle, bottle 30-70g. 使用前打开瓶盖,将塑料滚珠置于额头、太阳穴或大椎穴等处皮肤表面来回涂抹,每个部位可反复涂抹3至4次,为加快降温速度,可同时涂抹于腋窝、月国窝、大腿和小腿内侧等部位。 Before using open the bottle, the plastic ball placed on the forehead, temples or other places Dazhui surface of the skin back and forth smear, smear each part can be repeated 3-4 times, in order to accelerate the cooling rate, which can spread to the axillary, popliteal fossa, other parts of the inner thigh and calf.

[0054] 下面详细描述本发明的退热凝胶用于对致热家兔的退热试验: [0054] The present invention is described in detail below for fever gel pyrogenic fever tests on rabbits:

[0055] 观察试验: [0055] Observation test:

[0056] 1.试验材料:实验动物:健康新西兰大耳白兔,体重(2.4±0.3) kg,雌雄兼有。 [0056] 1. Test materials: Experiment Animals: New Zealand white rabbits, body weight (2.4 ± 0.3) kg, both male and female.

[0057] 药品:本发明退热凝胶。 [0057] Drugs: fever gel of the present invention.

[0058] 致热内毒素精制大肠埃希菌,由上海生物制品研究所提供,用无菌0.9%氯化钠注射液稀释,浓度20Ευ.πιΐΑ [0058] The purified E. coli endotoxin induced within the heat provided by Shanghai Institute of Biological Products, injection diluted with sterile 0.9% sodium chloride, the concentration 20Ευ.πιΐΑ

[0059] 仪器:电脑数字体温计,型号MC-3,辽药监(准)字第221002号。 [0059] Instrument: computer digital thermometer, model MC-3, Liao Drug Administration (quasi) No. 221,002.

[0060] 2试验方法 [0060] Test Method 2

[0061] 取健康大耳白兔42只,实验前3d,在室温22_25°C、湿度为55%_65%、通风环境下每天测动物肛温3次,使动物适应。 [0061] take a large healthy rabbits 42, before the experiment 3d, at room temperature 22_25 ° C, humidity of 55% _65%, measured rectal temperature and ventilating the animals 3 times a day, the animals adapt. 试验时将动物按体重大小随机分为7组,分别为治疗组 When the size of the test the animals body weight were randomly divided into 7 groups, were treated

1、治疗组2、治疗组3、治疗组4、对照组、0.9%氯化钠注射液、空白对照组。 1, treatment group 2 and treatment groups 3, 4 treatment group and control group, 0.9% sodium chloride injection, the control group. 每组动物腹部相应部位脱毛,面积4 cmX4 cm,脱毛后用0.9%氯化钠注射液洗净皮肤,每隔15m1n用电脑数字体温计测兔肛温1次,共测3次,求取其平均值为该动物基础体温。 Animal abdomen corresponding parts of each epilation, area 4 cmX4 cm, after depilation with 0.9% sodium chloride injection wash the skin, every computer 15m1n rabbit measured rectal temperature digital thermometer 1, a total of three times measurements, obtaining an average the animal is the basal body temperature. 按1mL -kg-Ι给药前6组兔耳缘静脉注射灭活大肠埃希菌制热,并于制热后30 m1n各组给予相应治疗;每组给按下述治疗方法给退热凝胶量均为4-5mL,每组均将退热凝胶覆于腹部脱毛部位,每2 h换药1次;0.9%氯化钠注射液按相同剂量给予1 mL.kg-0.9%氯化钠注射液灌胃;空白组未予任何药物治疗。 Before pressing 1mL -kg Ι-administered group 6 rabbit ear vein injection of inactivated E. coli heating and after heating 30 m1n groups treated accordingly; each according to the following method for treating a coagulation fever 4-5 mL glue are, each group will antipyretic gel overlying the abdomen hair removal site, the dressing was changed every 2 h; 0.9% sodium chloride injection administered 1 mL.kg-0.9% chloride, the same dose sodium injection gavage; control group received no drug treatment. 于给药后30、60、90、120、180、240、300及360m1n分别测兔肛温3次,取其均值,计算各组家兔各时段治疗后肛温与基础体温的差值,作统计学处理。 30,60,90,120,180,240,300 360m1n after administration and rectal temperature were measured in rabbit 3 times to obtain the average value, calculating the difference in basal body temperature and rectal temperature in each group of rabbits in each treatment period, for statistical analysis.

[0062] 2.1治疗方法: [0062] 2.1 Treatment:

[0063] 本发明治疗组1:将本发明上述实施例1的退热凝胶覆于腹部脱毛部位,每2 h换药1次,用量4-5ml。 [0063] The present invention is a treatment group: The gel fever above embodiments of the present invention is a hair removal site overlying the abdomen, dressing 1 every 2 h, the amount of 4-5ml.

[0064] 本发明治疗组2:将本发明上述实施例7的退热凝胶覆于腹部脱毛部位,每2 h换药1次,用量4-5ml。 [0064] The present invention treatment group 2: the gel fever 7 above embodiments of the invention in the abdomen overlying hair removal site, every 2 H dressing 1, the amount of 4-5ml.

[0065] 本发明治疗组3:将本发明上述实施例9的退热凝胶覆于腹部脱毛部位,每2 h换药1次,用量4-5ml。 [0065] The present invention treated group 3: the gel fever above embodiments of the invention 9 overlying the abdominal hair removal site, the dressing was changed every 2 h, the amount of 4-5ml.

[0066] 本发明治疗组4:将本发明上述实施例3的退热凝胶覆于腹部脱毛部位,每2 h换药1次,用量4-5ml。 [0066] Treatment group 4 of the present invention: The above-described embodiments of the present invention fever gel 3 overlying the abdominal hair removal site, the dressing was changed every 2 h, the amount of 4-5ml.

[0067] 对照组:将本发明上沭对照实施例1的退热凝胶覆于腹部脱毛部位,每2 h换药1次,用量4-5ml。 [0067] Control group: an upper control Shu embodiments of the present invention Example 1 fever gel overlying abdominal hair removal site, the dressing was changed every 2 h, the amount of 4-5ml.

[0068] 3数据记录: [0068] 3 data records:

[0069] 试验数据记录见表1 [0069] Test data is recorded in Table 1

[0070] 表1各组动物治疗后不同时段体温变化情况。 [0070] Table 1 Effect of temperature changes in time after treatment of animals in each group. C,±s C, ± s

[0071] [0071]

Figure CN103191185BD00081

[0072]注:与对照组相比,*Ρ〈0.05,☆★p<0.01。 [0072] Note: Compared with the control group, * Ρ <0.05, ☆ ★ p <0.01.

[0073] 由表1可以看出,[0074] 第一,本发明的治疗组(使用本发明退热凝胶)对致热家兔在给药后90min开始发挥退热作用,作用持续时间为360min,其退热效果和退热作用持续时间优于对照组,并且具有显著性差异(p〈0.05)。 [0073] As can be seen from Table 1, [0074] First, the treatment group (gel antipyretic the present invention) of the present invention is pyrogenic in rabbits 90min began to play a role in fever after administration, duration of action 360min, antipyretic its antipyretic effect and duration of action than the control group, and significant difference (p <0.05).

[0075] 第二,本发明治疗组4的效果与其他治疗组相比,效果最佳。 [0075] Second, the effect of the present invention, the treatment group compared with 4 other treatment groups, best results. 并且本发明治疗组与对照组相比,具有极其显著性差异(P〈0.01 )。 And the treatment group compared with the control group according to the present invention has an extremely significant difference (P <0.01). [0076] 以上所述仅为本发明的实施例,并非因此限制本发明的专利范围,凡是利用本发明说明书内容所作的等效结构或等效流程变换,或直接或间接运用在其他相关的技术领域,均同理包括在本发明的专利保护范围内。 [0076] The embodiments described above are only embodiments of the present invention, not intended to limit the scope of the present invention, the present invention is usually made by using a description equivalent structures or equivalent process, or applied directly or indirectly to other related art art shall fall within the scope of protection of the present invention.

Claims (9)

1.一种退热凝胶,其特征在于,按质量百分数包括:0.0Ol % -8%的水溶性薄荷油,0.0001 % -3%的保湿剂,0.01 % -3%的防腐剂; 所述保湿剂包括透明质酸钠、黄原胶、海藻酸钠、卡波姆中的至少一种; 所述防腐剂包括对氨基苯甲酸钠、羟苯乙酯、对羟基苯甲酸酯钠、尼泊金复合酯钠、苯扎氯铵中的至少一种; An antipyretic gel, characterized in that the percentage by mass comprising: 0.0Ol% -8% of a water soluble oil, 0.0001% to 3% humectant, from 0.01% to 3% preservative; the humectants include at least one of sodium, xanthan gum, sodium alginate, carbomer hyaluronic acid; an amino group of the preservatives include sodium benzoate, ethylparaben, sodium benzoate, p-hydroxybenzoic ester, paraben gold complex sodium acetate, benzalkonium chloride is at least one;
2.根据权利要求1所述的退热凝胶,其特征在于,所述退热凝胶包括水溶性薄荷油、保湿剂、对氨基苯甲酸钠; 所述保湿剂为透明质酸钠、黄原胶中的一种或两种。 The humectant xanthan sodium hyaluronate; antipyretic gel according to claim claim 1, wherein the gel comprises a water-soluble peppermint fever, humectants, p-aminobenzoic acid, sodium one or both of gum.
3.根据权利要求2所述的退热凝胶,其特征在于,所述的退热凝胶按质量百分数包括:0.001 % -8%的水溶性薄荷油,0.0001 % -3%的透明质酸钠,0.01 % -3%的对氨基苯甲酸钠;所述退热凝胶的PH值在4.0-8.0之间。 The antipyretic gel according to claim 2, wherein the mass percentage, antipyretic gel comprising: from 0.001% to 8% of a water soluble oil, 0.0001% to 3% hyaluronic acid Na, 0.01% -3% of sodium p-aminobenzoic acid; antipyretic the gel PH value between 4.0-8.0.
4.根据权利要求3所述的退热凝胶,其特征在于,所述的退热凝胶按质量百分数包括:0.1%-5 %的水溶性薄荷油,0.05%-1 %的透明质酸钠,0.1%-1 %的对氨基苯甲酸钠;所述退热凝胶的PH值在5.0-6.5之间。 The antipyretic gel according to claim 3, wherein said gel mass percentage, fever comprising: 0.1% to 5% of a water soluble oil, 0.05% to 1% of hyaluronic acid sodium, 0.1% to 1% of sodium p-aminobenzoic acid; antipyretic the gel PH value between 5.0-6.5.
5.根据权利要求2所述的退热凝胶,其特征在于,所述的退热凝胶按质量百分数包括:0.001 % -8%的水溶性薄荷油,0.01 % -7%的黄原胶,0.01 % -3%的对氨基苯甲酸钠;所述退热凝胶的PH值在4.0-8.0之间。 The antipyretic gel according to claim 2, wherein the mass percentage, antipyretic gel comprising: from 0.001% to 8% of a water soluble oil, 0.01% -7% xanthan gum 0.01% to 3%, sodium p-aminobenzoic acid; antipyretic the gel PH value between 4.0-8.0.
6.根据权利要求5所述的退热凝胶,其特征在于,所述的退热凝胶按质量百分数包括:0.1%-5 %的水溶性薄荷油,0.5%-4 %的黄原胶,0.1%-1 %的对氨基苯甲酸钠;所述退热凝胶的pH值在5.0-6.5之间。 The antipyretic gel according to claim 5, wherein said gel mass percentage, fever comprising: 0.1% to 5% of a water-soluble peppermint oil, 0.5% to 4% xanthan gum , 0.1% to 1% of sodium p-aminobenzoic acid; antipyretic the gel pH value between 5.0-6.5.
7.根据权利要求2-6中任一所述`的退热凝胶,其特征在于,所述的退热凝胶包括质量百分数为3 % -30%的乙醇。 2-6 according to any one of the `antipyretic gel claim, wherein the gel comprises by mass percent antipyretic 3% -30% ethanol.
8.根据权利要求7中所述的退热凝胶,其特征在于,所述乙醇的质量百分数为5%-20%。 Gel according to claim antipyretic in Claim 7, wherein the mass percentage of ethanol 5% to 20%.
9.根据权利要求7中所述的退热凝胶,其特征在于,所述退热凝胶的粘度在20-100mpa.s之间。 9. The antipyretic gel in Claim 7, wherein the viscosity of the gel between antipyretic 20-100mpa.s.
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102038746A (en) 2009-10-22 2011-05-04 上海中邦斯瑞生物药业技术有限公司 Antipyretic pharmaceutical composition
CN102166149A (en) 2010-11-29 2011-08-31 吴克 Antipyretic patch and preparation process thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102038746A (en) 2009-10-22 2011-05-04 上海中邦斯瑞生物药业技术有限公司 Antipyretic pharmaceutical composition
CN102166149A (en) 2010-11-29 2011-08-31 吴克 Antipyretic patch and preparation process thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
高艳等.外用水凝胶研究进展.《中国医药指南》.2007,第5卷(第11期),226-228.

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