CN103191185B - Antipyretic gel - Google Patents
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- CN103191185B CN103191185B CN 201310137722 CN201310137722A CN103191185B CN 103191185 B CN103191185 B CN 103191185B CN 201310137722 CN201310137722 CN 201310137722 CN 201310137722 A CN201310137722 A CN 201310137722A CN 103191185 B CN103191185 B CN 103191185B
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Abstract
The invention discloses antipyretic gel. The antipyretic gel comprises a water-soluble plant extract, a humectant and a preservative. The antipyretic gel can be used for physically bringing down a fever of a child and an adult caused by various reasons, applying cold compresses physiotherapy, relieving muscle pains, and physically cooling once burn occurs, and is particularly suitable for being used for relieving summer heat and cooling while working at high temperature; and the antipyretic gel is cool and refreshing, has no oiliness, and brings cool and comfortable feel to a user.
Description
Technical field
The present invention relates to medical technical field, relate in particular to a kind of antipyretic gel.
Background technology
As everyone knows, cause that the reason of fever is a lot, especially children fever is treated trouble especially, because of children's torso physiogeny incomplete, before not finding the reason that causes fever, can not be treated by use drug for abating fever simply, the easy like this state of an illness of covering, impact is treatment further.Therefore, have a fever at present below 38.5 ℃ that what advocate is to adopt the Physical temperature-lowering mode to bring down a fever.The product that possesses the physical cold treatment, brings down a fever of commonly using clinically in prior art is defervescence plaster used or the viscose glue of bringing down a fever.But find that in clinical use the defervescence plaster used or physics viscose glue of bringing down a fever persistent period of bringing down a fever is short, greasy clouding, the component distributing inequality.During dry weather, with rear skin, easily dewater, uncomfortable.Because clinical and product that pharmacy sells glycerol commonly used is as water suction moisturizing and lubricated substrate at present, glycerol has stronger hygroscopicity, can from air, absorb water, when air drying, the water in air molecule seldom, glycerol is obvious especially from human body skin direct draws water, particularly winter and Arid Area on the contrary.So just make Yin Gaowen fever itself drier with regard to the skin of hydropenia, affect the moisture retention of glycerol, the lasting fever time of preparation shortens, and causes the heating bounce-back.The more important thing is, science proves that glycerinated goods easily grow influenza virus, particularly bird flu virus.National health and Family Planning Committee announce: bird flu virus is in the situation that there is the glycerol existence can maintain vigour more than 1 year.And traditional physics defervescence plaster used and viscose glue of bringing down a fever of product of bringing down a fever all contains a large amount of glycerol compositions, while using these products, due to the above-mentioned characteristic of glycerol, easily cause cold virus not to be killed, repeated infection occurs or infect other people, incur loss through delay common cold treatment.The greasy of Mentholum and glycerol, make the people greasy clouding, uncomfortable with aftersensation in addition.
Herba Menthae is mainly containing volatile oil components such as nettle lotus brain, menthone.Think Herba Menthae " acrid in the mouth cool in nature has the merit of the dispelling wind-heat, Cheongju head, rash " on China's traditional Chinese medical science, think that it has excited brain, blood circulation promoting, diaphoresis, with the effect of antiinflammatory Tian pain, anti-itch detoxification and dispelling wind and heat pathogens.Doctor trained in Western medicine research thinks that the pharmacological action of Herba Menthae mainly contains: 1, local action: the aqua methnae topical application has the effect of refrigerant, antipruritic, antiinflammatory, pain relieving.Menthol energy chafe teleneuron sensor, first produce cool sensation, and slight burning sensation is arranged then.In saturating fell, cause long hyperemia, and reach therapeutical effect lentamente.2, analgesic: Herba Menthae energy stimulating central nervous system in a small amount makes telangiectasis on every side and dispels the heat; And promote sweat gland secretion and diaphoresis.Therefore the hypothermic effect of falling is arranged.3, antiinflammatory: the contained 8 kinds of catechu naphthols acid of Herba Menthae is effective antiinflammatory, can suppress 3a mono-hydroxysteroid dehydrogenase and has weak from antiinflammatory action.The contained blue Oleum sesami hydrocarbon of Herba Menthae has antiinflammatory action to scalding the rabbit ear.The present invention utilizes the agency part that plays Physical temperature-lowering in above-mentioned doctor trained in Western medicine research theory, adds water solublity Herba Menthae extract.
Due to the pharmacological action that Herba Menthae has, more gel or the ointment for bringing down a fever of the prior art, utilize Borneolum Syntheticum, Herba Menthae or Mentholum or Oleum menthae or other Folium Menthae extract to carry out the heat radiation of people's external use as main antipyretic and bring down a fever.The Chinese patent that application number is 200710202363 discloses a kind of defervescence paste, this defervescence paste by Herba Menthae, Borneolum Syntheticum, ethanol, glycerol by a certain percentage proportioning form.The Chinese patent that application number is 201110138429.3 discloses a kind of antipyretic gel, and this antipyretic gel is by raw material: carbomer, propylene glycol, ammonia, ethylparaben, Mentholum, Borneolum Syntheticum, second alcohol and water are uniformly mixed and gel by a certain percentage.
And the water solublity Herba Menthae oil Folium Menthae extracts such as Mentholum in medicinal different from the past, water solublity Herba Menthae oil is for antipyretic gel or the dew of bringing down a fever, can be at antipyretic gel or the aspects such as the sense organ exquisiteness revealed of bringing down a fever, appearance transparent, quality stability there is the effect of unique promotion potentiation synergistic function.And be different from Oleum menthae, water solublity Herba Menthae oil, can be directly soluble in water without separately adding cosolvent, is the homogeneous transparent state, feel submissive level and smooth.During the defervescence paste of the use of bringing down a fever at present, antipyretic gel or bring down a fever reveals there are no using the water solublity Oleum menthae.
Hyaluronate sodium is hyaluronic sodium-salt form.Hyaluronic acid is a kind of acid mucopolysaccharide, and the molecular structure that hyaluronic acid is unique with it and physicochemical property demonstrate multiple important physiological function in body, as lubricated joint, regulate the permeability of blood vessel wall, regulate protein, Water-Electrolyte diffusion and running, promote wound healing etc.Particularly importantly, hyaluronic acid has special water retention, is the best material of occurring in nature moisture retention of finding at present, is called as desirable nature moisturizing factor (Natural moisturizing factor, NMF).But hyaluronate sodium is multiplex in the moisture-keeping function of cosmetics, there are no the report for antipyretic gel, defervescence paste or the dew of bringing down a fever.
In sum, existing for the external preparation of bringing down a fever there are no utilizing water solublity Herba Menthae oil, hyaluronate sodium to coordinate to be brought down a fever.
Summary of the invention
Short in order to overcome defervescence plaster used or antipyretic gel physics of the prior art persistent period of bringing down a fever, greasy clouding, and use the technological deficiencies such as the easy dehydration of skin under dry weather, the invention provides a kind of antipyretic gel, be intended to bring down a fever for the physics of child and the heating that causes of adult's a variety of causes, cold compress physical therapy and alleviate muscular soreness and the Physical temperature-lowering while burning, be particularly useful for that relieve summer heat summer and the cooling of work in hot environment, defervescence preparation is refrigerant does not have an oiliness, makes user feel clearly comfortable.
For achieving the above object, the technical solution used in the present invention is: a kind of antipyretic gel comprises water soluble plant extract, wetting agent and antiseptic.
Preferably, described water soluble plant extract comprises at least one in water solublity Herba Menthae, water solublity Herba Menthae oil, water solublity Herba Menthae brain, Folium Nelumbinis extract.
Preferably, described wetting agent comprises at least one in hyaluronate sodium, xanthan gum, sodium alginate, carbomer; Described antiseptic comprises at least one in para aminobenzoic acid sodium salt, ethyl hydroxybenzoate, sodium methyl phydroxybenzoate, Nipagin complex esters sodium, benzalkonium chloride.
Preferably, described antipyretic gel comprises water solublity Herba Menthae oil, wetting agent, para aminobenzoic acid sodium salt; Described wetting agent is one or both in hyaluronate sodium, xanthan gum.
Water solublity Herba Menthae oil of the present invention is to utilize the straight molten technology of ultra micro emulsifying, adopt the extremely strong straight solvent of w-sp series of high efficiency of hydrophilic, by water-fast Oleum menthae be modified as can and water between form the dynamically stable hydrate of associativity such as coordination, compound, hydration, claim again layered, transparent brilliant liquid.Not only can reach straight water-soluble purpose, can also improve result of use, the biological chemical performance of water based product itself.Water solublity Herba Menthae oil is fine and smooth at the sense organ of antipyretic gel or the dew product of bringing down a fever, appearance transparent, and the aspects such as quality stability have the effect of unique promotion potentiation synergistic function.Water solublity Herba Menthae oil, can be directly soluble in water without separately adding cosolvent, is the homogeneous transparent state, feels submissive level and smooth.What the present invention's water solublity Herba Menthae oil used adopted is the water solublity Herba Menthae oil of being produced by Shanghai City Xin Jia spice company limited.Can prepare according to the preparation method described in " preparation of water solublity Herba Menthae oil " (Yu Xiquan, Huang Lifeng, Kang Luping, " Journal of Chinese Hospital Pharmacy " 10 phases in 1999) by water solublity Herba Menthae oil of the present invention.
Due to antipyretic gel or bring down a fever that to reveal be the external preparation for skin product, do not participate in microcirculation in human body, the impairing the liver kidney, continue Physical temperature-lowering, and the protection brain is the first-elected physics of the child foundation mode of bringing down a fever, and the antipyretic gel described in the present invention also can be made into the dew of bringing down a fever.
In the invention described above antipyretic gel, the core drug that plays the effect of bringing down a fever is water solublity Herba Menthae oil, and hyaluronate sodium is usingd its good moisture retention as wetting agent.Xanthan gum of the present invention is a kind of monospore polysaccharide produced by the yellow sporangium fermentation of vacation, due to its macromole particularity, structure and colloid property, and there is several functions, integrate emulsifying, suspension, thickening, moisturizing, infiltration etc., bionical lubricated, superior performance.The xanthan gum good water solubility, energy and water solublity Herba Menthae oil phase be collaborative, dissolving mutually, be uniformly distributed in solvent, be easy to smear, and the thickening characteristic possessed due to xanthan gum itself, make in the present invention and need not add again various thickening agents, and make solution itself possess certain viscosity, and can make water solublity Herba Menthae oil, hyaluronate sodium, well lasting distribution of ethanol in the present invention, evenly bring into play effect, non-stimulated to human body, avirulence.
But because the hyaluronate sodium cost of material is more expensive, and xanthan gum possesses hyaluronate sodium same performance in the present invention, can substitute fully or with the complementary synergism of hyaluronate sodium.The general character such as good wellability, moisture retention, water solublity are both arranged, can mutually organically combine, collaborative playing a role.
Para aminobenzoic acid sodium salt described in the present invention, rank: BR, be that the true biochemical reagents company limited in Shanghai is produced.
Preferably, above-mentioned antipyretic gel comprises by mass percent: the water solublity Herba Menthae oil of 0.001 ﹪-8%, the hyaluronate sodium of 0.0001 ﹪-3%, the para aminobenzoic acid sodium salt of 0.01 ﹪-3%; The pH value of described antipyretic gel is between 4.0-8.0.Further preferred, described antipyretic gel comprises by mass percent: the water solublity Herba Menthae oil of 0.1%-5 ﹪, the hyaluronate sodium of 0.05%-1 ﹪, the para aminobenzoic acid sodium salt of 0.1%-1 ﹪; The pH value of described antipyretic gel is between 5.0-6.5.
Preferably, above-mentioned antipyretic gel comprises by mass percent: the water solublity Herba Menthae oil of 0.001 ﹪-8%, the xanthan gum of 0.01 ﹪-7%, the para aminobenzoic acid sodium salt of 0.01 ﹪-3%; The pH value of described antipyretic gel is between 4.0-8.0; Further preferred, described antipyretic gel comprises by mass percent: the water solublity Herba Menthae oil of 0.1%-5 ﹪, the xanthan gum of 0.5%-4 ﹪, the para aminobenzoic acid sodium salt of 0.1%-1 ﹪; The pH value of described antipyretic gel is between 5.0-6.5.
The pH value of antipyretic gel of the present invention can adopt dilute hydrochloric acid to be regulated.
In the present invention, above-mentioned antipyretic gel also comprises the ethanol that mass percent is 3 ﹪-30%, and preferred, the mass percent of described ethanol is 5%-20 ﹪.
Ethanol described in the present invention is a kind of solvent in conventional formulation.Because Mentholum, Herba Menthae wet goods are water insoluble, very easily be dissolved in ethanol, so physics clinically is defervescence plaster used, all will add ethanol to dissolve Mentholum, the water-fast component of Herba Menthae wet goods in the viscose glue of bringing down a fever etc.Water solublity Herba Menthae oil in the present invention can be well soluble in water, do not need separately to add the lytic agents such as ethanol.But because ethanol has good infiltration and volatility, thus can add appropriate ethanol in the present invention, to increase the bringing down a fever property of physics of product.
The viscosity of antipyretic gel of the present invention is between 1-200 mpa.s.
Further, the viscosity of described antipyretic gel is between 20-100 mpa.s.
Above-mentioned antipyretic gel of the present invention also can be made into the dew of bringing down a fever, to facilitate use.
Water solublity Herba Menthae oil described in the present invention coordinates with xanthan gum or hyaluronate sodium, because of suspension, wellability, water solublity, moisture retention, gel thickening and the hyaluronate sodium of xanthan gum good moisturizing, infiltration and water solublity, can make lasting, the uniform performance infiltration of water solublity Herba Menthae oil and volatilization function, and can overcome the noncondensing characteristics of water solublity Herba Menthae oil under lower temperature conditions, add other chemical adjuvant, safer, non-stimulated, have no side effect.Be that xanthan gum and hyaluronate sodium in the present invention can be selected a use, but also both all use.
Antipyretic gel of the present invention is by water solublity Herba Menthae oil, hyaluronate sodium and/or xanthan gum, to carbamate sodium, ethanol, a kind of Physical temperature-lowering formed by the purified water mixing and stirring, a kind of product of cold treatment.Have fast, the fever time of bringing down a fever continue length, safety and comfort, without advantages such as greasy sense of discomfort, refrigerant franknesses.
The invention has the beneficial effects as follows: antipyretic gel of the present invention is brought down a fever soon, brought down a fever, and the persistent period is grown and salubrious cooling off oneself, and user is without greasy sense of discomfort.
The specific embodiment
Below preferred embodiment of the present invention is described in detail, thereby so that advantages and features of the invention can be easier to be it will be appreciated by those skilled in the art that, protection scope of the present invention is made to more explicit defining.
embodiment 1:a kind of antipyretic gel: water intaking dissolubility Oleum menthae 0.1g, hyaluronate sodium 1g, para aminobenzoic acid sodium salt 0.1g, each component is stirred, regulate pH value to 5.0 with dilute hydrochloric acid, add purified water to 100g, by each component mix homogeneously.
embodiment 2:a kind of antipyretic gel: water intaking dissolubility Oleum menthae 2g, hyaluronate sodium 0.1g, para aminobenzoic acid sodium salt 0.1g, medical ethanol 8 g stir each component, with dilute hydrochloric acid, regulate pH value to 6.0, add purified water to 100g, by each component mix homogeneously.
embodiment3: a kind of antipyretic gel, every 100g contains: water solublity Herba Menthae oil 2g, hyaluronate sodium 0.1g, xanthan gum 3g, to carbamate sodium 0.3g, medical ethanol 8g.Its preparation method is referring to embodiment 1.
embodiment4: a kind of antipyretic gel, every 100g contains: water solublity Herba Menthae oil 1g, hyaluronate sodium 0.7g, xanthan gum 1g, to carbamate sodium 0.2g, medical ethanol 10g.Its preparation method is referring to embodiment 1.
embodiment 5:a kind of antipyretic gel, every 100g contains: water solublity Herba Menthae oil 4 g, hyaluronate sodium 0.4g, xanthan gum 2g, to carbamate sodium 0.4 g, medical ethanol 15g.Its preparation method is referring to embodiment 1.
embodiment 6:a kind of antipyretic gel, every 100g contains: water solublity Herba Menthae oil 3g, hyaluronate sodium 1g, xanthan gum 0.5 g, to carbamate sodium 0.5g, medical ethanol 18g.Its preparation method is referring to embodiment 1.
embodiment 7:a kind of antipyretic gel: water intaking dissolubility Oleum menthae 5g, hyaluronate sodium 0.05g, para aminobenzoic acid sodium salt 0.1g, regulate pH value to 6.0 with dilute hydrochloric acid, add purified water to 100g, by each component mixing and stirring and get final product.
embodiment 8:a kind of antipyretic gel, it comprises by mass percent: 3% water solublity Herba Menthae oil, 0.5% hyaluronate sodium and 0.5% para aminobenzoic acid sodium salt.The preparation of this antipyretic gel can, with reference to above-described embodiment, make according to conventional adjusting process prescription.
embodiment 9:a kind of antipyretic gel, it comprises by mass percent: 8% water solublity Herba Menthae oil, 3% hyaluronate sodium, 3% para aminobenzoic acid sodium salt, 15% ethanol.The preparation of this antipyretic gel can, with reference to above-mentioned example, make according to conventional adjusting process prescription.
embodiment 10:a kind of dew of bringing down a fever, it comprises by mass percent: 8% water solublity Herba Menthae oil, 7% xanthan gum, 3% para aminobenzoic acid sodium salt.
embodiment 11:a kind of antipyretic gel, it comprises by mass percent: 5% water solublity Herba Menthae oil, 7% xanthan gum, 3% para aminobenzoic acid sodium salt, 20% ethanol.This antipyretic gel can, with reference to above-mentioned example, make according to conventional adjusting process prescription.
embodiment 12: a kind of antipyretic gel, it comprises by mass percent: 0.1% water solublity Herba Menthae oil, 4% xanthan gum, 0.1% para aminobenzoic acid sodium salt, 5% ethanol.This antipyretic gel can, with reference to above-mentioned example, make according to conventional adjusting process prescription.
embodiment 13:a kind of antipyretic gel, it comprises by mass percent: 0.1% water solublity Herba Menthae oil, 0.5% xanthan gum, 1% para aminobenzoic acid sodium salt.This antipyretic gel can, with reference to above-mentioned example, make according to conventional adjusting process prescription.
embodiment 14:a kind of antipyretic gel, it comprises by mass percent: 1% water solublity Herba Menthae oil, 0.8% hyaluronate sodium, 0.2% para aminobenzoic acid sodium salt, 10% ethanol.
This antipyretic gel of preparation 100g of take is example, water intaking dissolubility Oleum menthae 1 g, hyaluronate sodium 0.8g, to carbamate sodium 0.2 g, ethanol 10 g, add purified water and regulate pH value to 6.5 with dilute hydrochloric acid, quantitatively to 100g, by each component mixing and stirring and get final product.
embodiment 15:a kind of antipyretic gel, it comprises by mass percent: 4% water solublity Herba Menthae oil, 0.4% hyaluronate sodium, 0.6% para aminobenzoic acid sodium salt, 15% ethanol.
Preparation 100g this antipyretic gel of take is example, and water intaking dissolubility Oleum menthae 4 g, hyaluronate sodium 0.4g, to carbamate sodium 0.6g, ethanol 15 g add purified water and regulate pH value to 6.5 with dilute hydrochloric acid, by each component mixing and stirring and get final product.
embodiment 16:a kind of antipyretic gel, it comprises by mass percent: 6% water solublity Herba Menthae oil, 0.4% xanthan gum, 1.6% para aminobenzoic acid sodium salt, 15% ethanol.
Preparation 100g this antipyretic gel of take is example, and water intaking dissolubility Oleum menthae 4 g, xanthan gum 0.4g, to carbamate sodium 1.6g, ethanol 15 g add purified water, and regulate pH value to 6.0, quantitatively to 100g, by each component mixing and stirring and get final product.
embodiment 17:a kind of antipyretic gel, it comprises by mass percent: 3% water solublity Herba Menthae oil, 0.5% xanthan gum, 0.5% para aminobenzoic acid sodium salt, 18% ethanol.
embodiment 18:a kind of antipyretic gel, it comprises by mass percent: 2.5% water solublity Herba Menthae oil, 1% hyaluronate sodium, 0.5% para aminobenzoic acid sodium salt, 12% ethanol.
Preparation 100g this antipyretic gel of take is example, and water intaking dissolubility Oleum menthae 2.5g, hyaluronate sodium 1 g, to carbamate sodium 0.5g, ethanol 18g add purified water, and regulate pH value to 6.0, quantitatively to 100g, by each component mixing and stirring and get final product.
comparative examples 1a kind of antipyretic gel, every 100g contains: Mentholum 2g, hyaluronate sodium 0.1g, xanthan gum 3g, to carbamate sodium 0.3g, medical ethanol 8g.Its preparation method is referring to embodiment 1.
The present invention is local topical, during use, antipyretic gel of the present invention directly can be applied in to the skin surface at the positions such as patient's forehead, temple, DAZHUI acupoint, axillary fossa, popliteal nest, thigh and medial leg, utilize the principle of gel volatilization heat radiation, local cooling is carried out to auxiliary bringing down a fever; With existing defervescence plaster used technology, compare, antipyretic gel of the present invention, the effective percentage of bringing down a fever is high, cooling-down effect is remarkable.Perhaps, as another kind of external preparation mode of the present invention, after making the dew of bringing down a fever, can also divide to install to and smear in the ballpoint bottle, every bottle of 30-70g.Use the front opening bottle cap, the plastics ball is placed in to forehead, temple or DAZHUI acupoint etc. and locates skin surface and smear back and forth, each position can be smeared 3 to 4 times repeatedly, for accelerating cooling rate, can be applied in the positions such as axillary fossa, popliteal nest, thigh and medial leg simultaneously.
Below describe antipyretic gel of the present invention in detail and be used for the test of bringing down a fever to the pyrogenicity rabbit:
viewing test:
1. test material:laboratory animal: healthy New Zealand large ear rabbit, body weight (2.4 ± 0.3) kg, male and female have concurrently.
Medicine: antipyretic gel of the present invention.
The pyrogenicity endotoxin is made with extra care escherichia coli, by Shanghai Vaccine and Serum Institute, is provided, with aseptic 0.9% sodium chloride injection dilution, concentration 20EUmL
-1.
Instrument: computer numeral clinical thermometer, model MC-3, No. 221002nd, distant medicine prison (standard) word.
2 test methods
Get 42 of health large ear rabbits, 3d before experiment, room temperature 22-25 ℃, humidity be under 55%-65%, ventilated environment every day survey animal anus temperature 3 times, make the animal adaptation.During test, animal is divided into to 7 groups at random by the body weight size, is respectively treatment group 1, treatment group 2, treatment group 3, treatment group 4, matched group, 0.9% sodium chloride injection, blank group.Every treated animal abdominal part corresponding site depilation, area 4 cm * 4 cm, with 0.9% sodium chloride injection clearing skin, survey rabbit anus temperature 1 time every 15min with the computer digital clinical thermometer after depilation, surveys altogether 3 times, asks for its meansigma methods for this animal basal body temperature.By 6 groups of rabbit ear edge intravenous injection deactivation escherichia colis before the 1mLkg-1 administration, heat, and each group of 30 min gives corresponding treatment after heating; Every group is 4-5mL by following Therapeutic Method to the antipyretic gel amount, and every group all is overlying on antipyretic gel abdominal part depilation position, and every 2 h change dressings 1 time; 0.9% sodium chloride injection gives 1 mLkg by same dose
-10.9% sodium chloride injection gavage; Blank group is not given any Drug therapy.After administration 30,60,90,120,180,240,300 and 360min survey respectively rabbit anus temperature 3 times, get its average, calculate the difference respectively organize anus temperature and basal body temperature after the treatment of rabbit day part, processing takes statistics.
2.1 Therapeutic Method:
Treatment group 1 of the present invention: the antipyretic gel of the above embodiment of the present invention 1 is overlying on to abdominal part depilation position, and every 2 h change dressings 1 time, consumption 4-5ml.
Treatment group 2 of the present invention: the antipyretic gel of the above embodiment of the present invention 7 is overlying on to abdominal part depilation position, and every 2 h change dressings 1 time, consumption 4-5ml.
Treatment group 3 of the present invention: the antipyretic gel of the above embodiment of the present invention 9 is overlying on to abdominal part depilation position, and every 2 h change dressings 1 time, consumption 4-5ml.
Treatment group 4 of the present invention: the antipyretic gel of the above embodiment of the present invention 3 is overlying on to abdominal part depilation position, and every 2 h change dressings 1 time, consumption 4-5ml.
Matched group: the present invention is above-mentioned
comparative examples 1antipyretic gel be overlying on abdominal part depilation position, every 2 h change dressings 1 time, consumption 4-5ml.
3 data record:
The test data record is in Table 1
Different period body temperature situations of change after each treated animal treatment of table 1
℃, ± s
Annotate: with matched group, compare,
★ p<0.05,
☆ ★ p<0.01.
As can be seen from Table 1,
First, treatment group of the present invention (using antipyretic gel of the present invention) starts to bring into play antipyretic effect to pyrogenicity rabbit 90min after administration, acting duration is 360min, and its bring down a fever effect and antipyretic effect persistent period are better than matched group, and have significant difference (p<0.05).
The second, the effect for the treatment of group 4 of the present invention is compared with the other treatment group, best results.And treatment group of the present invention is compared with matched group, there is extremely significant difference (p<0.01).
The foregoing is only embodiments of the invention; not thereby limit the scope of the claims of the present invention; every equivalent structure or conversion of equivalent flow process that utilizes description of the present invention to do; or directly or indirectly be used in other relevant technical fields, all in like manner be included in scope of patent protection of the present invention.
Claims (9)
1. an antipyretic gel, is characterized in that, by mass percent, comprises: the water solublity Herba Menthae oil of 0.001 ﹪-8%, the wetting agent of 0.0001 ﹪-3%, the antiseptic of 0.01 ﹪-3%;
Described wetting agent comprises at least one in hyaluronate sodium, xanthan gum, sodium alginate, carbomer;
Described antiseptic comprises at least one in para aminobenzoic acid sodium salt, ethyl hydroxybenzoate, sodium methyl phydroxybenzoate, Nipagin complex esters sodium, benzalkonium chloride;
2. antipyretic gel according to claim 1, is characterized in that, described antipyretic gel comprises water solublity Herba Menthae oil, wetting agent, para aminobenzoic acid sodium salt;
Described wetting agent is one or both in hyaluronate sodium, xanthan gum.
3. antipyretic gel according to claim 2, is characterized in that, described antipyretic gel comprises by mass percent: the water solublity Herba Menthae oil of 0.001 ﹪-8%, the hyaluronate sodium of 0.0001 ﹪-3%, the para aminobenzoic acid sodium salt of 0.01 ﹪-3%; The pH value of described antipyretic gel is between 4.0-8.0.
4. antipyretic gel according to claim 3, is characterized in that, described antipyretic gel comprises by mass percent: the water solublity Herba Menthae oil of 0.1%-5 ﹪, the hyaluronate sodium of 0.05%-1 ﹪, the para aminobenzoic acid sodium salt of 0.1%-1 ﹪; The pH value of described antipyretic gel is between 5.0-6.5.
5. antipyretic gel according to claim 2, is characterized in that, described antipyretic gel comprises by mass percent: the water solublity Herba Menthae oil of 0.001 ﹪-8%, the xanthan gum of 0.01 ﹪-7%, the para aminobenzoic acid sodium salt of 0.01 ﹪-3%; The pH value of described antipyretic gel is between 4.0-8.0.
6. antipyretic gel according to claim 5, is characterized in that, described antipyretic gel comprises by mass percent: the water solublity Herba Menthae oil of 0.1%-5 ﹪, the xanthan gum of 0.5%-4 ﹪, the para aminobenzoic acid sodium salt of 0.1%-1 ﹪; The pH value of described antipyretic gel is between 5.0-6.5.
7. according to arbitrary described antipyretic gel in claim 2-6, it is characterized in that, described antipyretic gel comprises the ethanol that mass percent is 3 ﹪-30%.
8. according to the antipyretic gel described in claim 7, it is characterized in that, the mass percent of described ethanol is 5%-20 ﹪.
9. according to the antipyretic gel described in claim 7, it is characterized in that, the viscosity of described antipyretic gel is between 20-100 mpa.s.
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| CN 201310137722 CN103191185B (en) | 2013-04-20 | 2013-04-20 | Antipyretic gel |
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| CN 201310137722 CN103191185B (en) | 2013-04-20 | 2013-04-20 | Antipyretic gel |
Publications (2)
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| CN103191185A CN103191185A (en) | 2013-07-10 |
| CN103191185B true CN103191185B (en) | 2013-12-18 |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104784653A (en) * | 2014-01-17 | 2015-07-22 | 佛山市盛世泰康医药科技有限公司 | Defervesce plaster with dual cooling defervesce efficacies of physical cooling and absorption defervesce, and preparation method thereof |
| CN103784247A (en) * | 2014-03-05 | 2014-05-14 | 绍兴康宸医疗器械有限公司 | Cold therapy gel |
| CN105168208B (en) * | 2015-06-30 | 2019-01-01 | 武汉烺祺生物科技有限公司 | A kind of external drug brought down a fever and prevented heatstroke and lower the temperature of bringing down a fever |
| CN105616341A (en) * | 2016-03-08 | 2016-06-01 | 武汉烺祺生物科技有限公司 | Cold compress gel |
| CN105919981A (en) * | 2016-06-28 | 2016-09-07 | 江苏迪沃生物制品有限公司 | Defervescence patch and preparation process thereof |
| CN106691669A (en) * | 2016-12-01 | 2017-05-24 | 湖北硅金凝节能减排科技有限公司 | Antipyretic gel and roll-on device thereof |
| WO2020042097A1 (en) * | 2018-08-30 | 2020-03-05 | 江苏奇力康皮肤药业有限公司 | Real-time monitoring smart fever-reduction sticker |
| CN111388412A (en) * | 2018-12-31 | 2020-07-10 | 广西默士药业有限公司 | Plant polymer solution |
| CN111001033B (en) * | 2020-01-07 | 2022-06-21 | 承德一清环保科技有限公司 | High-efficiency hemostatic and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038746A (en) * | 2009-10-22 | 2011-05-04 | 上海中邦斯瑞生物药业技术有限公司 | Antipyretic pharmaceutical composition |
| CN102166149A (en) * | 2010-11-29 | 2011-08-31 | 吴克 | Antipyretic patch and preparation process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038746A (en) * | 2009-10-22 | 2011-05-04 | 上海中邦斯瑞生物药业技术有限公司 | Antipyretic pharmaceutical composition |
| CN102166149A (en) * | 2010-11-29 | 2011-08-31 | 吴克 | Antipyretic patch and preparation process thereof |
Non-Patent Citations (2)
| Title |
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| 外用水凝胶研究进展;高艳等;《中国医药指南》;20071125;第5卷(第11期);226-228 * |
| 高艳等.外用水凝胶研究进展.《中国医药指南》.2007,第5卷(第11期),226-228. |
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