CN108653247A - It is a kind of to have the defervescence plaster used preparation method for absorbing effect of bringing down a fever - Google Patents
It is a kind of to have the defervescence plaster used preparation method for absorbing effect of bringing down a fever Download PDFInfo
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- CN108653247A CN108653247A CN201810759801.4A CN201810759801A CN108653247A CN 108653247 A CN108653247 A CN 108653247A CN 201810759801 A CN201810759801 A CN 201810759801A CN 108653247 A CN108653247 A CN 108653247A
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- fever
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- defervescence plaster
- absorbing effect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
The invention discloses a kind of defervescence plaster used preparation method for having and absorbing effect of bringing down a fever, preparation method is：Weigh bulk pharmaceutical chemicals：68 parts of peppermint, 7 10 parts of cassia twig, 25 parts of ching-chieh, 12 18 parts of wrinkled giant hyssop, 10 12 parts of ginger；Above-mentioned raw materials medicine is mixed, micro mist is ground into；The fermentation of Bifidobacterium culture solution is added, filtering fermentating liquid obtains Chinese medicine extract；Chinese medicine extract is added in gel-type vehicle, is stirred evenly, is obtained drug containing hydrogel, deaerate in vacuum equipment, be made defervescence plaster used.Traditional Chinese drug antipyretic of the present invention patch have effects that it is clearing heat and detoxicating, deliver cold dispelling, arousing brain, raising spirit, analgesic antibacterial, enhance immunity of organisms, have the double effects that rapid physical cooling is brought down a fever with drug, treating both manifestation and root cause of disease, speed of bringing down a fever is fast, fever, myalgia caused by a variety of causes can effectively be dispelled, significant in efficacy, safety is good.
Description
Technical field
The invention belongs to application in TCM fields, more particularly to a kind of to have the defervescence plaster used preparation side for absorbing effect of bringing down a fever
Method.
Background technology
In daily life, people are frequently encountered tissue metabolism caused by fever, and fever caused by a variety of causes and increase
By force, dyspepsia, DOMS even unconsciousness, stupor etc..
It carries out Physical temperature-lowering at this stage, after fever and takes analgesic-antipyretic to be the measure that must be taken, Physical temperature-lowering
It is multi-purpose to stick defervescence plaster used mode, the hypothermic effect of drop is reached by the physical change of steam gasification heat absorption；Take antipyretic
It is then to adjust biological function in human body and reach cooling to bring down a fever purpose after being absorbed by oral drugs stomach.
The defervescence plaster used of commercial distribution can only carry out simple Physical temperature-lowering in the market, cannot be inherently eliminated the cause of disease；And
Oral antipyretic has certain side effect to stomach, meanwhile, when drug ingedient reaches the internal vital organs of the human body, liver has first mistake
Effect has different degrees of damage to liver.
Currently, it is existing it is defervescence plaster used have a single function, also have researcher attempt Chinese medicine carrying out the modes such as decocting it is simple
After extraction, it is added in hydrogel plaster, has the function that drug external use plaster cold compress, for example, CN103316315A discloses one kind
After the simple decocting extraction of Chinese medicine, extracting solution is added to the preparation method of hydrogel, which can reach cold compress physical therapy, relieve pain
Effect.But during this is defervescence plaster used, Chinese medicine is extracted using simple decocting method, impurity is more in liquid, the soda acid of liquid
Degree is unable to control, poor with the biocompatibility of skin, easily causes allergy, and it is relatively slow to work, effective component is difficult to fixed
Amount, due in the medicinal material that contains in prescription, there is certain toxic side effect, while having remaining heavy metal in medicinal material, and it is traditional
Herb powder or the Chinese medical extract using the extraction of common extracting method are added, problem above can not be avoided.It is this defervescence plaster used
In use, it is unable to reach high security.
Applicant's earlier patent application CN104784653A, which discloses one kind and having Physical temperature-lowering and absorption, to bring down a fever dual drop
Temperature is brought down a fever the defervescence plaster used of effect, component include natural mint extract, Ramulus Cinnamomi extract, Herba Schizonepetae extract, ageratum extract,
Ginger P.E, gel-type vehicle, which prepares Chinese medical extract using microorganism fermentation process, by effective component of chinese medicine by big
Molecule is converted to small molecule, can not only improve human body to active ingredient absorptivity, moreover it is possible to it is secondary to eliminate poison that may be present in medicinal material
Effect improves efficacy and saferry, but the patent does not disclose the consumption proportion of bulk pharmaceutical chemicals, and the preparation method of record is also more
It is ambiguous, it is difficult to carry out in actual application.
Invention content
Shortcoming in view of the above technology, the present invention is intended to provide a kind of raw material composition and the specific Chinese medicine of preparation method
Defervescence plaster used, significant in efficacy with high-biocompatibility, safety is good, treating both manifestation and root cause of disease, has what Physical temperature-lowering was brought down a fever with drug
Dual effect of bringing down a fever.
A kind of to have the defervescence plaster used preparation method for absorbing effect of bringing down a fever, preparation method is as follows：
(1) microculture：Bifid bacillus is taken, is expanded with conventional method and is cultivated, is counted under light microscopic, with culture keynote
Whole concentration, obtains microbial culture medium.
(2) preparation of Chinese medicine extract：Bulk pharmaceutical chemicals are weighed by weight ratio：6-8 parts of peppermint, 7-10 parts of cassia twig, ching-chieh
2-5 parts, 12-18 parts of wrinkled giant hyssop, 10-12 parts of ginger；Above-mentioned raw materials medicine is mixed, micro mist is ground into；Take micro-powder of Chinese herbs that micro- life is added
Object culture solution continues by old terms cultivation and fermentation, and filtering fermentating liquid obtains Chinese medicine extract；
(3) gel-type vehicle is prepared；
(4) Chinese medicine extract that step (2) obtains is added in gel-type vehicle obtained by step (3), stirs evenly, obtains drug containing
Hydrogel；
(5) the drug containing hydrogel that step (4) obtains is placed in vacuum equipment and is deaerated, the back of the body is coated on using calendering rubbing method
On lining, the another side adhering protective film layer of gel layer bonds three layers, is made defervescence plaster used.
Wherein, a concentration of (0.1-100) × 10 of the microbial culture medium described in step (1)8A/ml, preferably (1-10)
×108A/ml, most preferably 1 × 108A/ml.
Wherein, it is preferred that the weight proportion of the bulk pharmaceutical chemicals described in step (2) is：7 parts of peppermint, 10 parts of cassia twig, ching-chieh 4
Part, 16 parts of wrinkled giant hyssop, 11 parts of ginger.
Wherein, the amount ratio of the micro-powder of Chinese herbs described in step (2) and microbial culture medium is (10-200) g：500ml, it is excellent
Select (50-80) g：500ml, most preferably 50g：500ml.
Wherein, the fermentation time described in step (2) is 48-144 hours, preferably 96 hours.
Wherein, it is preferred that the preparation method of the Chinese medicine extract described in step (2) is as follows：Raw material is weighed by weight ratio
Medicine：7 parts of peppermint, 10 parts of cassia twig, 4 parts of ching-chieh, 16 parts of wrinkled giant hyssop, 11 parts of ginger；Above-mentioned raw materials medicine is mixed, 1 μ of grain size is ground into
The micro mist of m or so.It takes micro-powder of Chinese herbs 100g that microbial culture medium 500ml is added, continues by old terms culture 96 hours, filtering hair
Zymotic fluid obtains Chinese medicine extract.
Wherein, drug containing hydrogel substitutes water, using conventional disclosed in the prior art with the Chinese medicine extract described in step (2)
Method is made.Preferably, the gel-type vehicle described in step (3) is by carbomer, glycerine, propylene glycol, water-solubleazone, water for pharmaceutical purposes
It is made using conventional method disclosed in the prior art.Preferably, the weight percent of gel-type vehicle component is carbomer：1%-
3%, glycerine：2%-12%, propylene glycol：4%-12%, water-solubleazone：4.5%-5.5%, water for pharmaceutical purposes：Surplus；It is above-mentioned each
The summation of component is 100%.
Wherein, it is preferred that the weight ratio of Chinese medical extract and gel-type vehicle described in step (4) is 1：2-6.
Wherein, it is preferred that the thickness of the gel layer described in step (5) is 0.5-1.5mm.
The defervescence plaster used application method of the present invention is：Forehead or temple are pasted on, neck Dazhui acupoint can also be sticked on.
Daily 1-2 pieces, often paste 12 hours up times.
Compared with prior art, the beneficial effects of the invention are as follows：
(1) hydrogel patch is prepared using Chinese medical extract as active constituent, has rapid physical cooling and brings down a fever with drug
Dual effect of bringing down a fever.
(2) it takes microbial fermentation mode to extract medicinal material prescription, efficacy and saferry can be increased substantially.Micro- life
Macromolecular active principle not easily absorbed by the body can be degraded to small molecule easily absorbed by the body by the various enzymes that object generates to be had
Substance is imitated, while a variety of big molecular impurities can be removed, to improve absorptivity of the human body to active ingredient, improves drug effect.Meanwhile
The Chinese medicine extract contains the active biological enzyme of microorganism secretion, and skin can be promoted to serve as active bio to the absorption of drug
Bleeding agent improves osmotic efficiency, promotes curative effect.And the decomposition of microorganism can decompose noxious material, or in medicinal material
The toxic component of noxious material, which carries out modification, makes its toxicity reduce or disappear, and improves safety.
(3) Traditional Chinese drug antipyretic of the present invention patch have it is clearing heat and detoxicating, deliver cold dispelling, arousing brain, raising spirit, analgesic antibacterial, enhancing body are exempted from
The effect of epidemic disease power, has the double effects that rapid physical cooling is brought down a fever with drug, and treating both manifestation and root cause of disease, speed of bringing down a fever is fast, can effectively dispel
It is significant in efficacy except fever, myalgia caused by a variety of causes.Meanwhile drug absorption is absorbed without stomach, avoids the head of liver
Cross effect, during Physical temperature-lowering and drug absorption are brought down a fever, can effectively avoid endo-medicine to stomach liver can energy loss
Wound.
Specific implementation mode
With reference to embodiment, invention is further described in detail.
Embodiment 1
(1) microculture：Bifid bacillus is taken, is expanded with conventional method and is cultivated, is counted under light microscopic, with culture keynote
Whole a concentration of 1 × 108A/ml, obtains microbial culture medium.
(2) preparation of Chinese medicine extract：Bulk pharmaceutical chemicals are weighed by weight ratio：6 parts of peppermint, 7 parts of cassia twig, 2 parts of ching-chieh, the leaves of pulse plants
It is 12 parts fragrant, 10 parts of ginger；Above-mentioned raw materials medicine is mixed, the micro mist of 1 μm or so of grain size is ground into.Micro-powder of Chinese herbs 50g is taken to be added micro-
Bio-culture solution 500ml continues by old terms culture 48 hours, and filtering fermentating liquid obtains Chinese medicine extract；
(3) preparation of gel-type vehicle：A, gel-type vehicle component is weighed by weight percentage：Carbomer 1.5%, glycerine 2%,
Propylene glycol 4%, water-solubleazone 4.5%, water for pharmaceutical purposes surplus；The summation of above-mentioned each component is 100%；
B, carbomer is placed in container add it is medicinal water-swellable；
C, water-solubleazone, glycerine, propylene glycol are added in the product that b step obtains and are stirred, obtain gel-type vehicle；
(4) Chinese medicine extract that step (2) obtains is added in gel-type vehicle obtained by step (3) and is stirred, Chinese medicine extract
Weight ratio with gel-type vehicle is 1：1.5, obtain drug containing hydrogel；
(5) the drug containing hydrogel that step (4) obtains is placed in vacuum equipment and is deaerated, nothing is coated on using calendering rubbing method
On woven fabric back sheet, gel layer thicknesses 0.5mm bonds three layers using PU films as protection film layer, is made defervescence plaster used.
Embodiment 2
(1) microculture：Bifid bacillus is taken, is expanded with conventional method and is cultivated, is counted under light microscopic, with culture keynote
Whole a concentration of 1 × 108A/ml, obtains microbial culture medium.
(2) preparation of Chinese medicine extract：Bulk pharmaceutical chemicals are weighed by weight ratio：7 parts of peppermint, 8 parts of cassia twig, 3 parts of ching-chieh, the leaves of pulse plants
It is 15 parts fragrant, 11 parts of ginger；Above-mentioned raw materials medicine is mixed, the micro mist of 1 μm or so of grain size is ground into.Micro-powder of Chinese herbs 70g is taken to be added micro-
Bio-culture solution 500ml continues by old terms culture 72 hours, and filtering fermentating liquid obtains Chinese medicine extract；
(3) preparation of gel-type vehicle：A, gel-type vehicle component is weighed by weight percentage：Carbomer 2%, glycerine 6%, third
Glycol 6%, water-solubleazone 5%, water for pharmaceutical purposes surplus；The summation of above-mentioned each component is 100%；
B, carbomer is placed in container add it is medicinal water-swellable；
C, water-solubleazone, glycerine, propylene glycol are added in the product that b step obtains and are stirred, obtain gel-type vehicle；
(4) Chinese medicine extract that step (2) obtains is added in gel-type vehicle obtained by step (3) and is stirred, Chinese medicine extract
Weight ratio with gel-type vehicle is 1：3, obtain drug containing hydrogel；
(5) the drug containing hydrogel that step (4) obtains is placed in vacuum equipment and is deaerated, nothing is coated on using calendering rubbing method
On woven fabric back sheet, gel layer thicknesses 0.8mm bonds three layers using PU films as protection film layer, is made defervescence plaster used.
Embodiment 3
(1) microculture：Bifid bacillus is taken, is expanded with conventional method and is cultivated, is counted under light microscopic, with culture keynote
Whole a concentration of 3 × 108A/ml, obtains microbial culture medium.
(2) preparation of Chinese medicine extract：Bulk pharmaceutical chemicals are weighed by weight ratio：7 parts of peppermint, 10 parts of cassia twig, 4 parts of ching-chieh,
16 parts of wrinkled giant hyssop, 11 parts of ginger；Above-mentioned raw materials medicine is mixed, the micro mist of 1 μm or so of grain size is ground into.Micro-powder of Chinese herbs 100g is taken to be added
Microbial culture medium 500ml continues by old terms culture 96 hours, and filtering fermentating liquid obtains Chinese medicine extract；
(3) preparation of gel-type vehicle：A, gel-type vehicle component is weighed by weight percentage：Carbomer 2%, glycerine 8%, third
Glycol 8%, water-solubleazone 5%, water for pharmaceutical purposes surplus；The summation of above-mentioned each component is 100%；
B, carbomer is placed in container add it is medicinal water-swellable；
C, water-solubleazone, glycerine, propylene glycol are added in the product that b step obtains and are stirred, obtain gel-type vehicle；
(4) Chinese medicine extract that step (2) obtains is added in gel-type vehicle obtained by step (3) and is stirred, Chinese medicine extract
Weight ratio with gel-type vehicle is 1：2, obtain drug containing hydrogel；
(5) the drug containing hydrogel that step (4) obtains is placed in vacuum equipment and is deaerated, nothing is coated on using calendering rubbing method
On woven fabric back sheet, gel layer thicknesses 1.0mm bonds three layers using PU films as protection film layer, is made defervescence plaster used.
Embodiment 4
(1) microculture：Bifid bacillus is taken, is expanded with conventional method and is cultivated, is counted under light microscopic, with culture keynote
Whole a concentration of 8 × 108A/ml, obtains microbial culture medium.
(2) preparation of Chinese medicine extract：Bulk pharmaceutical chemicals are weighed by weight ratio：7 parts of peppermint, 8 parts of cassia twig, 5 parts of ching-chieh, the leaves of pulse plants
It is 17 parts fragrant, 12 parts of ginger；Above-mentioned raw materials medicine is mixed, the micro mist of 1 μm or so of grain size is ground into.Micro-powder of Chinese herbs 40g is taken to be added micro-
Bio-culture solution 500ml continues by old terms culture 144 hours, and filtering fermentating liquid obtains Chinese medicine extract；
(3) preparation of gel-type vehicle：A, gel-type vehicle component is weighed by weight percentage：Carbomer 3%, glycerine 10%,
Propylene glycol 11%, water-solubleazone 5.5%, water for pharmaceutical purposes surplus；The summation of above-mentioned each component is 100%；
B, carbomer is placed in container add it is medicinal water-swellable；
C, water-solubleazone, propylene glycol are added in the product that b step obtains and are stirred, obtain gel-type vehicle；
(4) Chinese medicine extract that step (2) obtains is added in gel-type vehicle obtained by step (3) and is stirred, Chinese medicine extract
Weight ratio with gel-type vehicle is 1：3, obtain drug containing hydrogel；
(5) the drug containing hydrogel that step (4) obtains is placed in vacuum equipment and is deaerated, nothing is coated on using calendering rubbing method
On woven fabric back sheet, gel layer thicknesses 1.5mm bonds three layers using PU films as protection film layer, is made defervescence plaster used.
Embodiment 5
(1) microculture：Bifid bacillus is taken, is expanded with conventional method and is cultivated, is counted under light microscopic, with culture keynote
Whole a concentration of 5 × 108A/ml, obtains microbial culture medium.
(2) preparation of Chinese medicine extract：Bulk pharmaceutical chemicals are weighed by weight ratio：8 parts of peppermint, 10 parts of cassia twig, 5 parts of ching-chieh,
17 parts of wrinkled giant hyssop, 12 parts of ginger；Above-mentioned raw materials medicine is mixed, the micro mist of 1 μm or so of grain size is ground into.Micro-powder of Chinese herbs 80g is taken to be added
Microbial culture medium 500ml continues by old terms culture 72 hours, and filtering fermentating liquid obtains Chinese medicine extract；
(3) preparation of gel-type vehicle：A, gel-type vehicle component is weighed by weight percentage：Carbomer 3%, glycerine 10%,
Propylene glycol 11%, water-solubleazone 5.5%, water for pharmaceutical purposes surplus；The summation of above-mentioned each component is 100%；
B, carbomer is placed in container add it is medicinal water-swellable；
C, water-solubleazone, glycerine, propylene glycol are added in the product that b step obtains and are stirred, obtain gel-type vehicle；
(4) Chinese medicine extract that step (2) obtains is added in gel-type vehicle obtained by step (3) and is stirred, Chinese medicine extract
Weight ratio with gel-type vehicle is 1：1.5, obtain drug containing hydrogel；
(5) the drug containing hydrogel that step (4) obtains is placed in vacuum equipment and is deaerated, nothing is coated on using calendering rubbing method
On woven fabric back sheet, gel layer thicknesses 1.5mm bonds three layers using PU films as protection film layer, is made defervescence plaster used.
To verify the effect of Traditional Chinese drug antipyretic patch of the present invention, inventor has carried out reality of bringing down a fever with Chinese medicine heat posted to pyrogenicity rabbit
It tests, using rabbit as experimental subjects, is studied, tried using fever in rabbits phenomenon caused by the defervescence plaster used escherichia coli to inactivation
It is as follows to test process：
One, bulk pharmaceutical chemicals match screening experiment
1. test medicine
The defervescence plaster used following table of raw material medicine composition：
1 bulk pharmaceutical chemicals weight proportion of table
| It is defervescence plaster used | Peppermint | Cassia twig | Ching-chieh | Wrinkled giant hyssop | Ginger |
| Formula 1 | 6 | 7 | 2 | 12 | 10 |
| Formula 2 | 7 | 8 | 3 | 15 | 11 |
| Formula 3 | 7 | 10 | 4 | 16 | 11 |
| Formula 4 | 7 | 8 | 5 | 17 | 12 |
| Formula 5 | 8 | 10 | 5 | 17 | 12 |
Defervescence plaster used preparation method is as follows：
(1) microculture：Bifid bacillus is taken, is expanded with conventional method and is cultivated, is counted under light microscopic, with culture keynote
Whole a concentration of 1 × 108A/ml, obtains microbial culture medium.
(2) preparation of Chinese medicine extract：Bulk pharmaceutical chemicals are weighed by formula shown in table 1；Bulk pharmaceutical chemicals are mixed, 1 μ of grain size is ground into
The micro mist of m or so.It takes micro-powder of Chinese herbs 50g that microbial culture medium 500ml is added, continues by old terms culture 96 hours, filtering hair
Zymotic fluid obtains Chinese medicine extract；
(3) a, gel-type vehicle component weight percent be：Carbomer 2%, glycerine 8%, propylene glycol 8%, water-soluble nitrogen
Ketone 5%, water for pharmaceutical purposes surplus；The summation of above-mentioned each component is 100%；
B, carbomer is placed in container add it is medicinal water-swellable；
C, water-solubleazone, glycerine, propylene glycol are added in the product that b step obtains and are stirred, obtain gel-type vehicle；
(4) Chinese medicine extract that step (2) obtains is added in gel-type vehicle obtained by step (3) and is stirred, Chinese medicine extract
Weight ratio with gel-type vehicle is 1：1.5, obtain drug containing hydrogel；
(5) the drug containing hydrogel that step (4) obtains is placed in vacuum equipment and is deaerated, nothing is coated on using calendering rubbing method
On woven fabric back sheet, gel layer thicknesses 1.5mm, area 3cm × 3cm bond three layers using PU films as protection film layer, are made
It is defervescence plaster used.
2. method
Take healthy New Zealand's large ear rabbit, 2.4 ± 0.3kg of weight, half male and half female, 3d before testing, 22~25 DEG C of room temperature,
Humidity is to survey animal anus temperature daily 3 times under 55%~65%, ventilated environment, for three days on end, animal is made to adapt to, and Thermal preference exists
38.0~39.2 DEG C, rabbit of the daily body temperature fluctuation within 0.3 DEG C is as animal subject.Animal is pressed into weight size when experiment
8 groups are randomly divided into, each 3 of every group of male and female, respectively blank control group, model control group, compound aspirin group, defervescence plaster used 1-
5 groups.
Every group of animal abdomen corresponding site depilation, area 4cm × 4cm clean skin after depilation with 0.9% sodium chloride injection
Skin.Start fasting 12 hours, free water before testing.Morning next day surveys rabbit anus temperature 1 every 30min computer digital clinical thermometers
It is secondary, it surveys 3 times altogether, it is the animal basal body temperature to seek its average value.In addition to blank control group, remaining 7 groups are pressed 1mL/kg rabbit ears
Edge intravenous injection inactivation escherichia coli pyrogenicity (being diluted with sterile 0.9% sodium chloride injection, concentration 20EU/mL), and in cause
30min each groups give corresponding treatment after heat.Defervescence plaster used group applies defervescence plaster used treatment in abdomen depilation position, per 2h dressings 1 time；It is multiple
By 13mg/kg administrations, (1300mg compound aspirins are dissolved in 0.9% sodium chloride injections of 100mL square aspirin group, are matched
It at a concentration of 1.3%, is treated by 1mL/kg gavages)；Model control group gives 0.9% sodium chloride injection 1mL/ by same dose
Kg gavages；Blank control group does not give any drug therapy.30,60,90,120,180,240,300 and 360min points after administration
Not Ce rabbit anus temperature 3 times, take its mean value, calculate the difference of anus temperature and basal body temperature after the treatment of each group rabbit day part, take statistics
Processing.
3. result
Different periods Temperature changing situation (mean+SD, n=6) after each group treatment of animals
Note：Compared with blank control group, * P<0.05, * * P<0.01.
Compared with model control group, #P<0.05, ##P<0.01.
Experiment conclusion：Blank control group body temperature is steady, fluctuates unobvious.Compared with blank control group, model control group man
60min body temperature obviously rises rabbit after the treatment, and 120-180min reaches peak value after treatment, then begins to slowly decline, until
Experiment terminates (360min after treatment), and model group rabbit body temperature is still significantly higher than blank control group.Compound aspirin treatment group
The speed that increases of rabbit body temperature slow down, amplification reduces, and 90min-360min observing times point is and model group after the treatment
Generate significant difference.Illustrate that modeling success, the treatment of positive control drug compound aspirin are effective.
Compared with model control group, speed that defervescence plaster used 1-5 treatment groups rabbit body temperature of the invention increases slows down, amplification subtracts
It is small, and 90min starts to play after the treatment, duration 360min, and effect of bringing down a fever is same as compound aspirin group, when effect
Between be longer than compound aspirin group.
Two, preparation process screening experiment
It is preferably formulated with " bulk pharmaceutical chemicals proportioning screening experiment ", screens condition of microbe fermentation.
With the preferred optimum extraction process of orthogonal experiment, factor level is as follows：
3 orthogonal experiment factor level of table
4 zymotechnique orthogonal experiment process conditions of table
| Experiment number | A | B |
| 1 | 1 | 1 |
| 2 | 1 | 2 |
| 3 | 1 | 3 |
| 4 | 2 | 1 |
| 5 | 2 | 2 |
| 6 | 2 | 3 |
| 7 | 3 | 1 |
| 8 | 3 | 2 |
| 9 | 3 | 3 |
Defervescence plaster used preparation method is as follows：
(1) microculture：Bifid bacillus is taken, is expanded with conventional method and is cultivated, is counted under light microscopic, with culture keynote
Whole a concentration of 1 × 108A/ml, obtains microbial culture medium.
(2) preparation of Chinese medicine extract：Bulk pharmaceutical chemicals are weighed by weight ratio：7 parts of peppermint, 10 parts of cassia twig, 4 parts of ching-chieh,
16 parts of wrinkled giant hyssop, 11 parts of ginger；Above-mentioned raw materials medicine is mixed, the micro mist of 1 μm or so of grain size is ground into.Micro-powder of Chinese herbs 100g is taken to be added
Microbial culture medium 500ml continues by old terms culture 96 hours, and filtering fermentating liquid obtains Chinese medicine extract；
(3) preparation of gel-type vehicle：A, gel-type vehicle component is weighed by weight percentage：Carbomer 2%, glycerine 8%, third
Glycol 8%, water-solubleazone 5%, water for pharmaceutical purposes surplus；The summation of above-mentioned each component is 100%；
B, carbomer is placed in container add it is medicinal water-swellable；
C, water-solubleazone, glycerine, propylene glycol are added in the product that b step obtains and are stirred, obtain gel-type vehicle；
(4) Chinese medicine extract that step (2) obtains is added in gel-type vehicle obtained by step (3) and is stirred, Chinese medicine extract
Weight ratio with gel-type vehicle is 1：2, obtain drug containing hydrogel；
(5) the drug containing hydrogel that step (4) obtains is placed in vacuum equipment and is deaerated, nothing is coated on using calendering rubbing method
On woven fabric back sheet, gel layer thicknesses 1.5mm, area 3cm × 3cm bond three layers using PU films as protection film layer, are made
It is defervescence plaster used.
2. method
Take healthy New Zealand's large ear rabbit, 2.4 ± 0.3kg of weight, half male and half female, 3d before testing, 22~25 DEG C of room temperature,
Humidity is to survey animal anus temperature daily 3 times under 55%~65%, ventilated environment, for three days on end, animal is made to adapt to, and Thermal preference exists
38.0~39.2 DEG C, rabbit of the daily body temperature fluctuation within 0.3 DEG C is as animal subject.Animal is pressed into weight size when experiment
It is randomly divided into 11 groups, it is each 3 of every group of male and female, respectively blank control group, model control group, compound aspirin group, defervescence plaster used
Experimental group 1-9 groups.
Every group of animal abdomen corresponding site depilation, area 4cm × 4cm clean skin after depilation with 0.9% sodium chloride injection
Skin.Start fasting 12 hours before testing, free water, morning next day surveys rabbit anus temperature 1 every 15min computer digital clinical thermometers
It is secondary, it surveys 3 times altogether, it is the animal basal body temperature to seek its average value.In addition to blank control group, remaining 7 groups are pressed 1mL/kg rabbit ears
Edge intravenous injection inactivation escherichia coli pyrogenicity (being diluted with sterile 0.9% sodium chloride injection, concentration 20EU/mL), and in cause
30min each groups give corresponding treatment after heat.Defervescence plaster used group applies defervescence plaster used treatment in abdomen depilation position, per 2h dressings 1 time；It is multiple
By 13mg/kg administrations, (1300mg compound aspirins are dissolved in 0.9% sodium chloride injections of 100mL square aspirin group, are matched
It at a concentration of 1.3%, is treated by 1mL/kg gavages)；Model control group gives 0.9% sodium chloride injection 1mL/ by same dose
Kg gavages；Blank control group does not give any drug therapy.30,60,90,120,180,240,300 and 360min points after administration
Not Ce rabbit anus temperature 3 times, take its mean value, calculate the difference of anus temperature and basal body temperature after the treatment of each group rabbit day part, take statistics
Processing.
Different periods Temperature changing situation (mean+SD, n=6) after each group treatment of animals
3. result
Different periods Temperature changing situation (mean+SD, n=6) after 5 each group treatment of animals of table
Note：Compared with blank control group, P<0.05, P<0.01.
Compared with model control group, P<0.05, P<0.01.
Experiment conclusion：Blank control group body temperature is steady, fluctuates unobvious.Compared with blank control group, model control group man
60min body temperature obviously rises rabbit after the treatment, and 120-180min reaches peak value after treatment, then begins to slowly decline, until
Experiment terminates (360min after treatment), and model group rabbit body temperature is still significantly higher than blank control group.Compound aspirin is given to control
After treatment, speed that rabbit body temperature increases slows down, amplification reduces, and 90min-360min observing times point is and model after the treatment
Group generates significant difference.Illustrate that modeling success, the treatment of positive control drug compound aspirin are effective.
Compared with model control group, speed that the defervescence plaster used experimental group 1-9 group rabbit body temperatures of the present invention increase slows down, amplification subtracts
It is small, and 90min-360min observing times point is identical as the effect of bringing down a fever that compound aspirin group generates after the treatment, and make
It is longer than compound aspirin group with the time, it is identical as compound aspirin illustrates that the defervescence plaster used experimental group 1-9 of the present invention is produced
Antipyretic effect.
Comparing the defervescence plaster used therapeutic effect of experimental group 1-9 of the present invention, the rabbit body temperature amplification of 8 groups of experimental group is minimum, and
120min, 180min produce the significant effect P that brings down a fever relative to model control group after the treatment<0.05), illustrate experimental group 8
The process conditions of group are optimum process, and defervescence plaster used curative effect obtained is best.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.
Claims (15)
1. a kind of having the defervescence plaster used preparation method for absorbing effect of bringing down a fever, which is characterized in that preparation method is as follows：
(1) microculture：Bifid bacillus is taken, is expanded with conventional method and is cultivated, is counted under light microscopic, is adjusted with culture medium dense
Degree, obtains microbial culture medium；
(2) preparation of Chinese medicine extract：Bulk pharmaceutical chemicals are weighed by weight ratio：6-8 parts of peppermint, 7-10 parts of cassia twig, ching-chieh 2-5
Part, 12-18 parts of wrinkled giant hyssop, 10-12 parts of ginger；Above-mentioned raw materials medicine is mixed, micro mist is ground into；Take micro-powder of Chinese herbs that microorganism training is added
Nutrient solution continues by old terms cultivation and fermentation, and filtering fermentating liquid obtains Chinese medicine extract；
(3) gel-type vehicle is prepared；
(4) Chinese medicine extract that step (2) obtains is added in gel-type vehicle obtained by step (3), stirs evenly, obtains drug containing water-setting
Glue；
(5) the drug containing hydrogel that step (4) obtains is placed in vacuum equipment and is deaerated, back sheet is coated on using calendering rubbing method
On, the another side adhering protective film layer of gel layer bonds three layers, is made defervescence plaster used.
2. a kind of according to claim 1 have the defervescence plaster used preparation method for absorbing effect of bringing down a fever, it is characterised in that：Step
(1) a concentration of (0.1-100) × 10 of the microbial culture medium described in8A/ml.
3. a kind of according to claim 1 have the defervescence plaster used preparation method for absorbing effect of bringing down a fever, it is characterised in that：Step
(1) a concentration of (1-10) × 10 of the microbial culture medium described in8A/ml.
4. a kind of according to claim 1 have the defervescence plaster used preparation method for absorbing effect of bringing down a fever, it is characterised in that：Step
(1) a concentration of 1 × 10 of microbial culture medium described in8A/ml.
5. a kind of according to claim 1 have the defervescence plaster used preparation method for absorbing effect of bringing down a fever, it is characterised in that：Step
(2) weight proportion of the bulk pharmaceutical chemicals described in is：7 parts of peppermint, 10 parts of cassia twig, 4 parts of ching-chieh, 16 parts of wrinkled giant hyssop, 11 parts of ginger.
6. a kind of according to claim 1 have the defervescence plaster used preparation method for absorbing effect of bringing down a fever, it is characterised in that：Step
(2) amount ratio of micro-powder of Chinese herbs and microbial culture medium described in is (10-200) g：500ml.
7. a kind of according to claim 1 have the defervescence plaster used preparation method for absorbing effect of bringing down a fever, it is characterised in that：Step
(2) amount ratio of micro-powder of Chinese herbs and microbial culture medium described in is (50-80) g：500ml.
8. a kind of according to claim 1 have the defervescence plaster used preparation method for absorbing effect of bringing down a fever, it is characterised in that：Step
(2) amount ratio of micro-powder of Chinese herbs and microbial culture medium described in is 50g：500ml.
9. a kind of according to claim 1 have the defervescence plaster used preparation method for absorbing effect of bringing down a fever, it is characterised in that：Step
(2) fermentation time described in is 48-144 hours.
10. a kind of according to claim 1 have the defervescence plaster used preparation method for absorbing effect of bringing down a fever, it is characterised in that：Step
Suddenly the fermentation time described in (2) is 96 hours.
11. a kind of according to claim 1 have the defervescence plaster used preparation method for absorbing effect of bringing down a fever, it is characterised in that：Step
Suddenly the preparation method of the Chinese medicine extract described in (2) is as follows：Bulk pharmaceutical chemicals are weighed by weight ratio：7 parts of peppermint, 10 parts of cassia twig, chaste tree
4 parts of mustard fringe, 16 parts of wrinkled giant hyssop, 11 parts of ginger；Above-mentioned raw materials medicine is mixed, the micro mist of 1 μm or so of grain size is ground into；Take micro-powder of Chinese herbs
Microbial culture medium 500ml is added in 100g, continues by old terms culture 96 hours, filtering fermentating liquid obtains Chinese medicine extract.
12. a kind of according to claim 1 have the defervescence plaster used preparation method for absorbing effect of bringing down a fever, it is characterised in that：Step
Suddenly the gel-type vehicle described in (3) is used by carbomer, glycerine, propylene glycol, water-solubleazone, water for pharmaceutical purposes disclosed in the prior art
Conventional method is made.
13. a kind of according to claim 1 have the defervescence plaster used preparation method for absorbing effect of bringing down a fever, it is characterised in that：Step
Suddenly the gel-type vehicle described in (3) is made of the raw material of following weight percent：Carbomer 1%-3%, glycerine 2%-12%, the third two
Alcohol 4%-12%, water-solubleazone 4.5%-5.5%, water for pharmaceutical purposes surplus；The summation of above-mentioned each component is 100%.
14. a kind of according to claim 1 have the defervescence plaster used preparation method for absorbing effect of bringing down a fever, it is characterised in that：Step
Suddenly the weight ratio of the Chinese medicine extract described in (4) and gel-type vehicle is 1：2-6.
15. a kind of according to claim 1 have the defervescence plaster used preparation method for absorbing effect of bringing down a fever, it is characterised in that：Step
Suddenly the thickness of the gel layer described in (5) is 0.5-1.5mm.
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Cited By (2)
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| CN109620523A (en) * | 2018-11-01 | 2019-04-16 | 郭锦明 | It is a kind of with alleviating eye strain, steam eye patch of efficacy of tranquilizing mind and improving sleeping and preparation method thereof |
| CN115252754A (en) * | 2022-08-11 | 2022-11-01 | 佛山市盛世泰康医药科技有限公司 | A topical plant medicinal composition with physical cooling and fever reducing effects, and its preparation method |
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| CN104784653A (en) * | 2014-01-17 | 2015-07-22 | 佛山市盛世泰康医药科技有限公司 | Defervesce plaster with dual cooling defervesce efficacies of physical cooling and absorption defervesce, and preparation method thereof |
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| CN109620523A (en) * | 2018-11-01 | 2019-04-16 | 郭锦明 | It is a kind of with alleviating eye strain, steam eye patch of efficacy of tranquilizing mind and improving sleeping and preparation method thereof |
| CN115252754A (en) * | 2022-08-11 | 2022-11-01 | 佛山市盛世泰康医药科技有限公司 | A topical plant medicinal composition with physical cooling and fever reducing effects, and its preparation method |
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Effective date of registration: 20181128 Address after: 528200 Second Floor 03A, Building 10A, Agricultural Products Wholesale Market, Dali Guijiang, Foshan City, Guangdong Province, Nanhai District, Foshan City Applicant after: Flourishing age Tai Kang Pharmaceutical Technology Co., Ltd of Foshan City Applicant after: Meng Qinghua Address before: 528200 Second Floor 03A, Building 10A, Agricultural Products Wholesale Market, Dali Guijiang, Foshan City, Guangdong Province, Nanhai District, Foshan City Applicant before: Flourishing age Tai Kang Pharmaceutical Technology Co., Ltd of Foshan City |
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