CN104784653A - Defervesce plaster with dual cooling defervesce efficacies of physical cooling and absorption defervesce, and preparation method thereof - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicine application, and especially relates to a defervesce plaster with dual cooling defervesce efficacies of physical cooling and absorption defervesce. The defervesce plaster comprises a natural mint extract product, a cassia twig extract product, a schizonepeta spike extract product, a wrinkled gianthyssop extract product, a ginger extract product and a gel matrix.

Description

A kind of possess Physical temperature-lowering and absorb dual cooling of bringing down a fever and to bring down a fever the defervescence plaster used and preparation method thereof of effect

Technical field

The invention belongs to application in TCM field, particularly a kind of possess Physical temperature-lowering and absorb dual cooling of bringing down a fever and to bring down a fever the defervescence plaster used of effect.

Background technology

In daily life, people often can run into the fever that a variety of causes causes, and the tissue metabolism caused of having a fever strengthens, and the dyspepsia, muscular soreness is unconsciousness even, stupor etc.

In present stage, carrying out Physical temperature-lowering after fever and taking antipyretic analgesic is the measure that must take, and Physical temperature-lowering is multiplex sticks defervescence plaster used mode, is reached fall hypothermic effect by the physical change of steam gasification heat absorption; Taking febrifuge is then after being absorbed by oral drugs stomach, regulates biological function in human body to reach cooling and to bring down a fever object.

On market, the defervescence plaster used of commercial distribution can only carry out simple Physical temperature-lowering, fundamentally can not eliminate the cause of disease; And oral febrifuge, have certain side effect to the intestines and stomach, meanwhile, when ingredient arrives the vital organs of the human body in body, liver has first pass effect, has damage in various degree to liver.

At present, existing defervescence plaster used function singleness, also research worker is had to attempt Chinese crude drug to carry out after the modes such as decocting simply extract, add in hydrogel plaster, reach the effect of medicine external use plaster cold compress, such as, after CN103316315A discloses the simple decocting extraction of a kind of Chinese medicine, extracting solution is added the preparation method of hydrogel, this invention can reach cold compress physical therapy, lenitive effect.But, during this is defervescence plaster used, use simple decocting method to extract Chinese medicine, in medicinal liquid, impurity is many, and the acid-base value of medicinal liquid is uncontrollable, poor with the biocompatibility of skin, easily cause allergy, and onset is relatively slow, active ingredient is difficult to quantitatively, due in the medical material that contains in prescription, there is certain toxic and side effects, there is residual heavy metal in medical material simultaneously, and the Chinese medicine extract that tradition is added Chinese medicinal powder or utilized common extracting method to extract, above problem cannot be avoided.This in use defervescence plaster used, cannot high security be reached.

Therefore, invention is a kind of easy to use, non-stimulated to skin, has stronger biocompatibility, safer, and possessing again Physical temperature-lowering and absorb the defervescence plaster used of dual effect of bringing down a fever of bringing down a fever, is the difficult problem of this area.

Summary of the invention

For the weak point of above-mentioned technology, the invention provides a kind of safer, high-biocompatibility, evident in efficacy, treating both the principal and secondary aspects of a disease, possesses microorganism and promotes the Physical temperature-lowering of osmotic absorption effect and absorb the defervescence plaster used of dual effect of bringing down a fever of bringing down a fever.

A kind of possess Physical temperature-lowering and absorb dual cooling of bringing down a fever and to bring down a fever the defervescence plaster used of effect, comprises following component: natural Folium Menthae extract, Ramulus Cinnamomi extract, Herba Schizonepetae extract, Radix agastaches extract, Rhizoma Zingiberis Recens extract, gel-type vehicle.

Wherein, described gel-type vehicle consists of carbomer, glycerol, propylene glycol, water-solubleazone, water for pharmaceutical purposes.

A preparation method defervescence plaster used as above, comprises following preparation process:

1) preparation of Chinese medicine extraction liquid, by Chinese crude drug fine powder, soak, make constant temperature 37 ± 0.5 DEG C, add in the culture fluid be made up of the outer enzyme of the born of the same parents such as microorganism and the protease secreted by it, cellulase, hemicellulase, pectic substance, lignin, under temperature constant state, keep 48 hours, stir at any time, make crude drug cell wall and iuntercellular cellulose, hemicellulose degradation, reach the object of cell wall breaking cellular wall, filtering fermentating liquid, obtain Chinese medicine extraction liquid;

2) preparation of gel-type vehicle, a, carbomer being placed in container, to add pharmaceutical purpose water-soluble swollen; B, water-solubleazone, propylene glycol be added in product that a step obtains and stir;

3) by 1) Chinese medicine extraction liquid that obtains is added to 2) stir in product after step;

4) product that step 3) obtains is placed in vacuum equipment degassed, adopts calendering rubbing method to make defervescence plaster used.

Compared with prior art, the invention has the beneficial effects as follows, microbial fermentation mode is taked to carry out extraction to medical material prescription, increase substantially effective component extraction rate, after microorganism is extracted, in medical material, effective ingredient changes into micromolecule by macromole, the while of making active ingredient of Chinese herbs exempt from destroyed, improves drug effect, improves human body to effective ingredient absorbance; Meanwhile, eliminate the toxic and side effects that may exist in medical material, eliminate residual heavy metal in medical material; After being replaced by medicinal liquid part moisture content to make hydrogel, the extracting solution containing amount of activated enzyme, can promote that skin is to the absorption of medicine, serves as active bio penetrating agent, improves osmotic efficiency, promotes curative effect.Thus to fever patient provide possess rapid physical cooling and drug osmotic absorb the dual effect of bringing down a fever of bringing down a fever.The drug matching used in the present invention and active biological enzyme extracting mode Effective Component of Chinese Medicine, the hydrogel patch be made up of extracting solution again, composition percutaneous dosing (treatment) system, make defervescence plaster used to there is heat-clearing and toxic substances removing, deliver cold expelling, refreshment, pain relieving is antibacterial, effect of enhancing human body immunity power, effectively can dispel the heating that a variety of causes causes, myalgia, evident in efficacy, speed of bringing down a fever is fast, while treating both the principal and secondary aspects of a disease, drug absorption absorbs without the intestines and stomach, the head of liver is avoided to act on, in the process that Physical temperature-lowering and drug absorption are brought down a fever, effectively can avoid endo-medicine may damage the intestines and stomach liver.

Detailed description of the invention

Below in conjunction with embodiment, the present invention is described in further detail.

At 37 ± 0.5 DEG C, the conventional strain groups such as target beneficial flora are inserted culture medium to cultivate, after flora liquid maturation, dilute with at warm water 37 ± 0.5 DEG C, insert in the fermentation tank be equipped with by the complete micro-powder of Chinese herbs prescription of following weight compatibility, ferment at 37 ± 0.5 DEG C, after 48 hours, extracting solution is filtered, obtain the medicinal liquid containing active component extract.Select prior art to prepare hydrogel, hydrogel plaster adopts non-woven fabrics as backing layer 1, and carbomer, glycerol, propylene glycol, water-solubleazone, water for pharmaceutical purposes and the medicinal liquid containing active component extract are made pro-skin water type gel layer; 2, gel layer 2 thickness is at 0.5 ~ 1.5mm, and backing layer 1 another side is printed on required pattern, and the formula of described employing pro-skin water type gel is known technology, and the medicinal liquid containing active component extract is equal to water.Adopt with backing layer PU film of the same area as protective film; 3, described protective film 3 covers the entire area that backing layer 1 is coated with the one side of gel layer 2, by bonding three layers, obtained defervescence plaster used.

Using method: stick in forehead or temple, also can stick on cervical region DAZHUI acupoint.Every day, 1-2 sheet, often pasted 12 hours up times.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (3)

1. one kind possesses Physical temperature-lowering and absorbs dual cooling of bringing down a fever and to bring down a fever the defervescence plaster used of effect, it is characterized in that, comprises following component: natural Folium Menthae extract, Ramulus Cinnamomi extract, Herba Schizonepetae extract, Radix agastaches extract, Rhizoma Zingiberis Recens extract, gel-type vehicle.

2. defervescence plaster used as claimed in claim 1, it is characterized in that, described gel-type vehicle consists of carbomer, glycerol, propylene glycol, water-solubleazone, water for pharmaceutical purposes.

3. the defervescence plaster used preparation method as described in above-mentioned any claim, is characterized in that, comprises following preparation process:

1) preparation of Chinese medicine extraction liquid, by Chinese crude drug fine powder, soak, make constant temperature 37 ± 0.5 DEG C, add in the culture fluid be made up of the outer enzyme of the born of the same parents such as microorganism and the protease secreted by it, cellulase, hemicellulase, pectic substance, lignin, under temperature constant state, keep 48 hours, stir at any time, make crude drug cell wall and iuntercellular cellulose, hemicellulose degradation, reach the object of cell wall breaking cellular wall, filtering fermentating liquid, obtain Chinese medicine extraction liquid;

2) preparation of gel-type vehicle, a, carbomer being placed in container, to add pharmaceutical purpose water-soluble swollen; B, water-solubleazone, propylene glycol be added in product that a step obtains and stir;

3) by 1) Chinese medicine extraction liquid that obtains is added to 2) stir in product after step;

4) product that step 3) obtains is placed in vacuum equipment degassed, adopts calendering rubbing method to make defervescence plaster used.