CN105688166A - Medical cold compress paster and preparation method thereof - Google Patents
Medical cold compress paster and preparation method thereof Download PDFInfo
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- CN105688166A CN105688166A CN201610162623.8A CN201610162623A CN105688166A CN 105688166 A CN105688166 A CN 105688166A CN 201610162623 A CN201610162623 A CN 201610162623A CN 105688166 A CN105688166 A CN 105688166A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F7/0241—Apparatus for the preparation of hot packs, hot compresses, cooling pads, e.g. heaters or refrigerators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0203—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor
- A61F2007/0215—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor containing liquids other than water
- A61F2007/0219—Gels
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0225—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof
- A61F2007/0226—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof adhesive, self-sticking
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0244—Compresses or poultices for effecting heating or cooling with layers
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0261—Compresses or poultices for effecting heating or cooling medicated
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- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/3606—General characteristics of the apparatus related to heating or cooling cooled
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Abstract
The invention relates to the technical field of medical supplies, in particular to a medical cold compress paster, comprising a back lining layer, a gel layer and a covering layer which are sequentially connected from top to bottom, wherein the gel layer is prepared from the following raw material by mass percent: 5-20% of macromolecular substance, 3-10% of fresh ginger extract, 3-10% of radix angelicae pubescentis extract, 2-8% of cortex phellodendri extract, 3-8% of philippine violet herb extract, 3-12% of fructus forsythiae extract, 1-7% of indigo naturalis powder, 2-8% of ethyl alcohol, 1-10% of humectant, 0.25-9% of auxiliary agent and the balance of water. The medical cold compress paster has the advantages that 1, the medical cold compress paster is capable of evenly cooling for a long time and is obvious in an effect of abatement of fever; 2, the medical cold compress paster is good in biocompatibility and free from irritation and toxic or side effect; 3, the medical cold compress paster has functions of carrying out cold compress physical therapy, physically cooling, bringing down a fever, cooling blood to remove stasis and relieving pain; the medical cold compress paster is safe and convenient to use.
Description
Technical field
The present invention relates to field of medical article technology, particularly relate to a kind of Medical cold and apply ointment or plaster and preparation method thereof。
Background technology
Cold compress is a kind of relatively inexpensive cold compress therapy undertaken by Physical temperature-lowering。Traditional Cold-compress mainly uses frozen water, ice cube, ethanol etc., but these method cold compress times are short, large usage quantity, and cold compress effect is uneven, it is easy to cause part frozen, carries and preserves inconvenience。
It is undesirable to there is cooling-down effect in the domestic cold compress patch product in current Chinese market, the shortcomings such as the continued down time is short, poor adhesion, cooling blood and removing stasis DeGrain, and the cold compress patch series products of foreign brand name to there is price higher, it is difficult to universal shortcoming。
Summary of the invention
The present invention provides a kind of Medical cold and applies ointment or plaster and preparation method thereof for overcoming drawbacks described above, and the preparation method that this Medical cold is applied ointment or plaster is simple, and technology of preparing is controlled, and cost is low；This Medical cold is applied ointment or plaster and is had the advantage that 1, cooling is lasting uniformly, effect of bringing down a fever is obvious；2, good biocompatibility, non-stimulated, have no side effect；3, there is cold compress physical therapy, Physical temperature-lowering, bring down a fever and bring down a fever, cooling blood and removing stasis, lenitive effect, use conveniently, safely。
For achieving the above object, the present invention adopts the following technical scheme that。
A kind of Medical cold is applied ointment or plaster, and including the backing layer being sequentially connected with from top to bottom, gel layer and cover layer, described gel layer includes the raw material of following mass percent:
Polymer substance can absorb and keep substantial amounts of moisture to form gel, the gel of its formation has good stability and adhesiveness, enable cold compress patch good be attached on skin so that it is the moisture of carrying, cooling ingredient and Chinese medicine ingredients material can be fully contacted with skin。
Ginger extract has effect of relieving the exterior syndrome by diaphoresis, removing toxic substances, cool pain-alleviating。Modern study shows: Rhizoma Zingiberis Recens has the effect regulating immunologic function, and energy is scavenging hydroxyl well, has obvious antiinflammatory and suppresses the effect of allergy。
Radix Angelicae Pubescentis in Radix Angelicae Pubescentis extracting solution is to apply conventional Chinese medicine very frequently, Radix Angelicae Pubescentis nature and flavor acrid, bitter, warm, has expelling wind and removing dampness, numbness relieving and pain relieving, effect of inducing sweat。
Cortex Phellodendri in cortex phellodendri extract has the effect of heat clearing and damp drying, eliminating fire and detoxication, detumescence putrefaction removing, and various skin noxious dampness, skin infection are had good effect。
It is cold in nature for Herba Violae in Herba Violae extracting solution, bitter in the mouth, pungent, has effect that heat-clearing and toxic substances removing, removing heat from blood are subsided a swelling。
Multiple gram-positive and negative bacterium are all had inhibitory action by the Fructus Forsythiae in Fructus Forsythiae extracting solution, have the effects such as stronger antibacterial and antiviral, also have heat-clearing and toxic substances removing, dispersing swelling and dissipating binds effect in addition。
Indigo Naturalis has effect of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, pathogenic fire purging arresting convulsion, anti-inflammatory and antalgic。
Ethanol is as conventional solvent, use mainly as the solvent of menthyl lactate in the present invention, ethanol also has the effect of sterilizing, skin can be carried out sterilizing with after contact skin, the volatility of ethanol is stronger, substantial amounts of heat can be taken away in skin, thus having the effect of cooling when volatilization。
Wetting agent has and prevents gel layer from hardening, it is prevented that gel layer moisture evaporation is too fast, thus reaching the effect making cold compress patch continued down bring down a fever, moreover it is possible to make skin moisturizing moisturizing, it is prevented that xerosis cutis。
Glycyrrhizic acid dipotassium has and prevents xerosis cutis, effect antipruritic, antianaphylactic, thus preventing contact skin to produce allergic phenomena。
Menthyl lactate and water solublity Oleum menthae use mainly as freshener, cooling effect is obvious, the refrigerant persistent period is long, the heat in skin is taken away thus arriving the effect of refrigerant cooling by its refrigerant effect, and they also have good biocompatibility, the effect of anti-inflammation, safe and non-stimulating。
Preferably, described gel layer includes the raw material of following mass percent:
Preferably, described gel layer includes the raw material of following mass percent:
Wherein, described auxiliary agent includes glycyrrhizic acid dipotassium, water solublity Oleum menthae and menthyl lactate, it is 0.1～2% that described glycyrrhizic acid dipotassium accounts for the percentage ratio of described gel layer raw material gross mass, it is 0.05～3% that described water solublity Oleum menthae accounts for the percentage ratio of described gel layer raw material gross mass, and it is 0.1～4% that described menthyl lactate accounts for the percentage ratio of described gel layer raw material gross mass。
Wherein, described polymer substance is one or more mixture of sodium polyacrylate, carbomer, sodium alginate, sodium carboxymethyl cellulose, chitosan quaternary ammonium salt。
Wherein, described wetting agent is one or more mixture of glycerol, butanediol, Aloe Barbadensis Miller juice, sorbitol。
Wherein, described backing layer is non-woven fabrics backing layer, and described water is deionized water, and described cover layer is polyethylene film cover。
Wherein, described ginger extract is the juice being filtrated to get with 80 mesh filter screens after Rhizoma Zingiberis Recens squeezing；
Described Radix Angelicae Pubescentis extracting solution be by cleaned for Radix Angelicae Pubescentis bark, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, the medicinal liquid that obtains after concentration；
Described cortex phellodendri extract is mix with water after being pulverized by Cortex Phellodendri, first adds cellulase and carries out enzymolysis processing, then carries out decocting extraction, filtering, gained supernatant dehydrated alcohol precipitates, and refilters, gained supernatant is removed dehydrated alcohol the medicinal liquid obtained with mixed with propylene glycol。
Wherein, described Herba Violae extracting solution be Herba Violae is cleaned, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, the medicinal liquid that obtains after concentration；
Described Fructus Forsythiae extracting solution, for being cleaned by Fructus Forsythiae, dry, being ground into coarse powder, carries out continuous circumfluence extraction with water, 30% ethanol, 50% ethanol, 70% ethanol, 95% ethanol respectively, and extracting solution is condensed into the medicinal liquid being equivalent to crude drug 1mg/ml；
Described Indigo Naturalis powder is the powder that Indigo Naturalis is filtrated to get with 100 eye mesh screens after pulverizing。
The preparation method that a kind of Medical cold is applied ointment or plaster, including following procedure of processing:
Step A, weigh each raw material according to the formula of gel layer, standby；
Step B, polymer substance is added part water, make polymer substance swelling, obtain the swelling body of macromolecule, standby；
Step C, menthyl lactate is dissolved in ethanol, obtains the alcoholic solution of menthyl lactate, standby；
Step D, water solublity Oleum menthae, wetting agent, ginger extract, Radix Angelicae Pubescentis extracting solution, cortex phellodendri extract, Herba Violae extracting solution, Fructus Forsythiae extracting solution, Indigo Naturalis powder, glycyrrhizic acid dipotassium are added in part water, stir, obtain mixed liquor；
Step E, the alcoholic solution of swelling for macromolecule body and menthyl lactate is joined in mixed liquor, add excess water and regulate viscosity, stir, namely obtain gel；
Step F, being spread evenly across by gel on non-woven fabrics backing layer, press polyethylene film and cover, namely packaging obtains Medical cold and applies ointment or plaster finished product。
The invention have the benefit that
A kind of Medical cold of the present invention is applied ointment or plaster, including the backing layer being sequentially connected with from top to bottom, gel layer and cover layer, described gel layer includes the raw material of following mass percent: polymer substance 5～20%, ginger extract 3～10%, Radix Angelicae Pubescentis extracting solution 3～10%, cortex phellodendri extract 2～8%, Herba Violae extracting solution 3～8%, Fructus Forsythiae extracting solution 3～12%, Indigo Naturalis powder 1～7%, ethanol 2～8%, wetting agent 1～10%, auxiliary agent 0.25～9%, water surplus；This Medical cold is applied ointment or plaster and is had the advantage that 1, cooling is lasting uniformly, effect of bringing down a fever is obvious；2, good biocompatibility, non-stimulated, have no side effect；3, there is cold compress physical therapy, Physical temperature-lowering, bring down a fever and bring down a fever, cooling blood and removing stasis, lenitive effect, use conveniently, safely；
The preparation method that a kind of Medical cold of the present invention is applied ointment or plaster, including following procedure of processing: step A, weigh each raw material according to the formula of gel layer, standby；Step B, polymer substance is added part water, make polymer substance swelling, obtain the swelling body of macromolecule, standby；Step C, menthyl lactate is dissolved in ethanol, obtains the alcoholic solution of menthyl lactate, standby；Step D, water solublity Oleum menthae, wetting agent, ginger extract, Radix Angelicae Pubescentis extracting solution, cortex phellodendri extract, Herba Violae extracting solution, Fructus Forsythiae extracting solution, Indigo Naturalis powder, glycyrrhizic acid dipotassium are added in part water, stir, obtain mixed liquor；Step E, the alcoholic solution of swelling for macromolecule body and menthyl lactate is joined in mixed liquor, add excess water and regulate viscosity, stir, namely obtain gel；Step F, being spread evenly across by gel on non-woven fabrics backing layer, press polyethylene film and cover, namely packaging obtains Medical cold and applies ointment or plaster finished product；The preparation method that this Medical cold is applied ointment or plaster is simple, and technology of preparing is controlled, and cost is low, and production efficiency is high, and conforming product rate is high, is suitable for large-scale promotion application。
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated, and this is presently preferred embodiments of the present invention。
Embodiment 1。
A kind of Medical cold of the present embodiment is applied ointment or plaster, and including the backing layer being sequentially connected with from top to bottom, gel layer and cover layer, described gel layer includes the raw material of following mass percent:
The auxiliary agent of the present embodiment includes glycyrrhizic acid dipotassium, water solublity Oleum menthae and menthyl lactate, it is 1.5% that described glycyrrhizic acid dipotassium accounts for the percentage ratio of described gel layer raw material gross mass, it is 1.5% that described water solublity Oleum menthae accounts for the percentage ratio of described gel layer raw material gross mass, and it is 2% that described menthyl lactate accounts for the percentage ratio of described gel layer raw material gross mass。
The polymer substance of the present embodiment is sodium polyacrylate。
The wetting agent of the present embodiment is glycerol。
The backing layer of the present embodiment is non-woven fabrics backing layer, and described water is deionized water, and described cover layer is polyethylene film cover。
The ginger extract of the present embodiment is the juice being filtrated to get with 80 mesh filter screens after Rhizoma Zingiberis Recens squeezing；
Described Radix Angelicae Pubescentis extracting solution be by cleaned for Radix Angelicae Pubescentis bark, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, the medicinal liquid that obtains after concentration；
Described cortex phellodendri extract is mix with water after being pulverized by Cortex Phellodendri, first adds cellulase and carries out enzymolysis processing, then carries out decocting extraction, filtering, gained supernatant dehydrated alcohol precipitates, and refilters, gained supernatant is removed dehydrated alcohol the medicinal liquid obtained with mixed with propylene glycol。
The Herba Violae extracting solution of the present embodiment be Herba Violae is cleaned, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, the medicinal liquid that obtains after concentration；
Described Fructus Forsythiae extracting solution, for being cleaned by Fructus Forsythiae, dry, being ground into coarse powder, carries out continuous circumfluence extraction with water, 30% ethanol, 50% ethanol, 70% ethanol, 95% ethanol respectively, and extracting solution is condensed into the medicinal liquid being equivalent to crude drug 1mg/ml；
Described Indigo Naturalis powder is the powder that Indigo Naturalis is filtrated to get with 100 eye mesh screens after pulverizing。
The preparation method that a kind of Medical cold is applied ointment or plaster, including following procedure of processing:
Step A, weigh each raw material according to the formula of gel layer, standby；
Step B, polymer substance is added part water, make polymer substance swelling, obtain the swelling body of macromolecule, standby；
Step C, menthyl lactate is dissolved in ethanol, obtains the alcoholic solution of menthyl lactate, standby；
Step D, water solublity Oleum menthae, wetting agent, ginger extract, Radix Angelicae Pubescentis extracting solution, cortex phellodendri extract, Herba Violae extracting solution, Fructus Forsythiae extracting solution, Indigo Naturalis powder, glycyrrhizic acid dipotassium are added in part water, stir, obtain mixed liquor；
Step E, the alcoholic solution of swelling for macromolecule body and menthyl lactate is joined in mixed liquor, add excess water and regulate viscosity, stir, namely obtain gel；
Step F, being spread evenly across by gel on non-woven fabrics backing layer, press polyethylene film and cover, namely packaging obtains Medical cold and applies ointment or plaster finished product。
Embodiment 2。
A kind of Medical cold of the present embodiment is applied ointment or plaster, and including the backing layer being sequentially connected with from top to bottom, gel layer and cover layer, described gel layer includes the raw material of following mass percent:
The auxiliary agent of the present embodiment includes glycyrrhizic acid dipotassium, water solublity Oleum menthae and menthyl lactate, it is 2% that described glycyrrhizic acid dipotassium accounts for the percentage ratio of described gel layer raw material gross mass, it is 3% that described water solublity Oleum menthae accounts for the percentage ratio of described gel layer raw material gross mass, and it is 4% that described menthyl lactate accounts for the percentage ratio of described gel layer raw material gross mass。
The polymer substance of the present embodiment is carbomer。
The wetting agent of the present embodiment is butanediol。
The backing layer of the present embodiment is non-woven fabrics backing layer, and described water is deionized water, and described cover layer is polyethylene film cover。
The ginger extract of the present embodiment is the juice being filtrated to get with 80 mesh filter screens after Rhizoma Zingiberis Recens squeezing；
Described Radix Angelicae Pubescentis extracting solution be by cleaned for Radix Angelicae Pubescentis bark, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, the medicinal liquid that obtains after concentration；
Described cortex phellodendri extract is mix with water after being pulverized by Cortex Phellodendri, first adds cellulase and carries out enzymolysis processing, then carries out decocting extraction, filtering, gained supernatant dehydrated alcohol precipitates, and refilters, gained supernatant is removed dehydrated alcohol the medicinal liquid obtained with mixed with propylene glycol。
The Herba Violae extracting solution of the present embodiment be Herba Violae is cleaned, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, the medicinal liquid that obtains after concentration；
Described Fructus Forsythiae extracting solution, for being cleaned by Fructus Forsythiae, dry, being ground into coarse powder, carries out continuous circumfluence extraction with water, 30% ethanol, 50% ethanol, 70% ethanol, 95% ethanol respectively, and extracting solution is condensed into the medicinal liquid being equivalent to crude drug 1mg/ml；
Described Indigo Naturalis powder is the powder that Indigo Naturalis is filtrated to get with 100 eye mesh screens after pulverizing。
The preparation method that a kind of Medical cold is applied ointment or plaster, including following procedure of processing:
Step A, weigh each raw material according to the formula of gel layer, standby；
Step B, polymer substance is added part water, make polymer substance swelling, obtain the swelling body of macromolecule, standby；
Step C, menthyl lactate is dissolved in ethanol, obtains the alcoholic solution of menthyl lactate, standby；
Step D, water solublity Oleum menthae, wetting agent, ginger extract, Radix Angelicae Pubescentis extracting solution, cortex phellodendri extract, Herba Violae extracting solution, Fructus Forsythiae extracting solution, Indigo Naturalis powder, glycyrrhizic acid dipotassium are added in part water, stir, obtain mixed liquor；
Step E, the alcoholic solution of swelling for macromolecule body and menthyl lactate is joined in mixed liquor, add excess water and regulate viscosity, stir, namely obtain gel；
Step F, being spread evenly across by gel on non-woven fabrics backing layer, press polyethylene film and cover, namely packaging obtains Medical cold and applies ointment or plaster finished product。
Embodiment 3。
A kind of Medical cold of the present embodiment is applied ointment or plaster, and including the backing layer being sequentially connected with from top to bottom, gel layer and cover layer, described gel layer includes the raw material of following mass percent:
The auxiliary agent of the present embodiment includes glycyrrhizic acid dipotassium, water solublity Oleum menthae and menthyl lactate, it is 0.1% that described glycyrrhizic acid dipotassium accounts for the percentage ratio of described gel layer raw material gross mass, it is 0.05% that described water solublity Oleum menthae accounts for the percentage ratio of described gel layer raw material gross mass, and it is 0.1% that described menthyl lactate accounts for the percentage ratio of described gel layer raw material gross mass。
The polymer substance of the present embodiment is sodium alginate。
The wetting agent of the present embodiment is Aloe Barbadensis Miller juice。
The backing layer of the present embodiment is non-woven fabrics backing layer, and described water is deionized water, and described cover layer is polyethylene film cover。
The ginger extract of the present embodiment is the juice being filtrated to get with 80 mesh filter screens after Rhizoma Zingiberis Recens squeezing；
Described Radix Angelicae Pubescentis extracting solution be by cleaned for Radix Angelicae Pubescentis bark, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, the medicinal liquid that obtains after concentration；
Described cortex phellodendri extract is mix with water after being pulverized by Cortex Phellodendri, first adds cellulase and carries out enzymolysis processing, then carries out decocting extraction, filtering, gained supernatant dehydrated alcohol precipitates, and refilters, gained supernatant is removed dehydrated alcohol the medicinal liquid obtained with mixed with propylene glycol。
The Herba Violae extracting solution of the present embodiment be Herba Violae is cleaned, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, the medicinal liquid that obtains after concentration；
Described Fructus Forsythiae extracting solution, for being cleaned by Fructus Forsythiae, dry, being ground into coarse powder, carries out continuous circumfluence extraction with water, 30% ethanol, 50% ethanol, 70% ethanol, 95% ethanol respectively, and extracting solution is condensed into the medicinal liquid being equivalent to crude drug 1mg/ml；
Described Indigo Naturalis powder is the powder that Indigo Naturalis is filtrated to get with 100 eye mesh screens after pulverizing。
The preparation method that a kind of Medical cold is applied ointment or plaster, including following procedure of processing:
Step A, weigh each raw material according to the formula of gel layer, standby；
Step B, polymer substance is added part water, make polymer substance swelling, obtain the swelling body of macromolecule, standby；
Step C, menthyl lactate is dissolved in ethanol, obtains the alcoholic solution of menthyl lactate, standby；
Step D, water solublity Oleum menthae, wetting agent, ginger extract, Radix Angelicae Pubescentis extracting solution, cortex phellodendri extract, Herba Violae extracting solution, Fructus Forsythiae extracting solution, Indigo Naturalis powder, glycyrrhizic acid dipotassium are added in part water, stir, obtain mixed liquor；
Step E, the alcoholic solution of swelling for macromolecule body and menthyl lactate is joined in mixed liquor, add excess water and regulate viscosity, stir, namely obtain gel；
Step F, being spread evenly across by gel on non-woven fabrics backing layer, press polyethylene film and cover, namely packaging obtains Medical cold and applies ointment or plaster finished product。
Embodiment 4。
A kind of Medical cold of the present embodiment is applied ointment or plaster, and including the backing layer being sequentially connected with from top to bottom, gel layer and cover layer, described gel layer includes the raw material of following mass percent:
The auxiliary agent of the present embodiment includes glycyrrhizic acid dipotassium, water solublity Oleum menthae and menthyl lactate, it is 1% that described glycyrrhizic acid dipotassium accounts for the percentage ratio of described gel layer raw material gross mass, it is 1% that described water solublity Oleum menthae accounts for the percentage ratio of described gel layer raw material gross mass, and it is 1% that described menthyl lactate accounts for the percentage ratio of described gel layer raw material gross mass。
The polymer substance of the present embodiment is sodium carboxymethyl cellulose。
The wetting agent of the present embodiment is sorbitol。
The backing layer of the present embodiment is non-woven fabrics backing layer, and described water is deionized water, and described cover layer is polyethylene film cover。
The ginger extract of the present embodiment is the juice being filtrated to get with 80 mesh filter screens after Rhizoma Zingiberis Recens squeezing；
Described Radix Angelicae Pubescentis extracting solution be by cleaned for Radix Angelicae Pubescentis bark, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, the medicinal liquid that obtains after concentration；
Described cortex phellodendri extract is mix with water after being pulverized by Cortex Phellodendri, first adds cellulase and carries out enzymolysis processing, then carries out decocting extraction, filtering, gained supernatant dehydrated alcohol precipitates, and refilters, gained supernatant is removed dehydrated alcohol the medicinal liquid obtained with mixed with propylene glycol。
The Herba Violae extracting solution of the present embodiment be Herba Violae is cleaned, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, the medicinal liquid that obtains after concentration；
Described Fructus Forsythiae extracting solution, for being cleaned by Fructus Forsythiae, dry, being ground into coarse powder, carries out continuous circumfluence extraction with water, 30% ethanol, 50% ethanol, 70% ethanol, 95% ethanol respectively, and extracting solution is condensed into the medicinal liquid being equivalent to crude drug 1mg/ml；
Described Indigo Naturalis powder is the powder that Indigo Naturalis is filtrated to get with 100 eye mesh screens after pulverizing。
The preparation method that a kind of Medical cold is applied ointment or plaster, including following procedure of processing:
Step A, weigh each raw material according to the formula of gel layer, standby；
Step B, polymer substance is added part water, make polymer substance swelling, obtain the swelling body of macromolecule, standby；
Step C, menthyl lactate is dissolved in ethanol, obtains the alcoholic solution of menthyl lactate, standby；
Step D, water solublity Oleum menthae, wetting agent, ginger extract, Radix Angelicae Pubescentis extracting solution, cortex phellodendri extract, Herba Violae extracting solution, Fructus Forsythiae extracting solution, Indigo Naturalis powder, glycyrrhizic acid dipotassium are added in part water, stir, obtain mixed liquor；
Step E, the alcoholic solution of swelling for macromolecule body and menthyl lactate is joined in mixed liquor, add excess water and regulate viscosity, stir, namely obtain gel；
Step F, being spread evenly across by gel on non-woven fabrics backing layer, press polyethylene film and cover, namely packaging obtains Medical cold and applies ointment or plaster finished product。
Embodiment 5。
A kind of Medical cold of the present embodiment is applied ointment or plaster, and including the backing layer being sequentially connected with from top to bottom, gel layer and cover layer, described gel layer includes the raw material of following mass percent:
The auxiliary agent of the present embodiment includes glycyrrhizic acid dipotassium, water solublity Oleum menthae and menthyl lactate, it is 2% that described glycyrrhizic acid dipotassium accounts for the percentage ratio of described gel layer raw material gross mass, it is 2% that described water solublity Oleum menthae accounts for the percentage ratio of described gel layer raw material gross mass, and it is 2% that described menthyl lactate accounts for the percentage ratio of described gel layer raw material gross mass。
The polymer substance of the present embodiment is chitosan quaternary ammonium salt。
The wetting agent of the present embodiment is glycerol。
The backing layer of the present embodiment is non-woven fabrics backing layer, and described water is deionized water, and described cover layer is polyethylene film cover。
The ginger extract of the present embodiment is the juice being filtrated to get with 80 mesh filter screens after Rhizoma Zingiberis Recens squeezing；
Described Radix Angelicae Pubescentis extracting solution be by cleaned for Radix Angelicae Pubescentis bark, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, the medicinal liquid that obtains after concentration；
Described cortex phellodendri extract is mix with water after being pulverized by Cortex Phellodendri, first adds cellulase and carries out enzymolysis processing, then carries out decocting extraction, filtering, gained supernatant dehydrated alcohol precipitates, and refilters, gained supernatant is removed dehydrated alcohol the medicinal liquid obtained with mixed with propylene glycol。
The Herba Violae extracting solution of the present embodiment be Herba Violae is cleaned, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, the medicinal liquid that obtains after concentration；
Described Fructus Forsythiae extracting solution, for being cleaned by Fructus Forsythiae, dry, being ground into coarse powder, carries out continuous circumfluence extraction with water, 30% ethanol, 50% ethanol, 70% ethanol, 95% ethanol respectively, and extracting solution is condensed into the medicinal liquid being equivalent to crude drug 1mg/ml；
Described Indigo Naturalis powder is the powder that Indigo Naturalis is filtrated to get with 100 eye mesh screens after pulverizing。
The preparation method that a kind of Medical cold is applied ointment or plaster, including following procedure of processing:
Step A, weigh each raw material according to the formula of gel layer, standby；
Step B, polymer substance is added part water, make polymer substance swelling, obtain the swelling body of macromolecule, standby；
Step C, menthyl lactate is dissolved in ethanol, obtains the alcoholic solution of menthyl lactate, standby；
Step D, water solublity Oleum menthae, wetting agent, ginger extract, Radix Angelicae Pubescentis extracting solution, cortex phellodendri extract, Herba Violae extracting solution, Fructus Forsythiae extracting solution, Indigo Naturalis powder, glycyrrhizic acid dipotassium are added in part water, stir, obtain mixed liquor；
Step E, the alcoholic solution of swelling for macromolecule body and menthyl lactate is joined in mixed liquor, add excess water and regulate viscosity, stir, namely obtain gel；
Step F, being spread evenly across by gel on non-woven fabrics backing layer, press polyethylene film and cover, namely packaging obtains Medical cold and applies ointment or plaster finished product。
Embodiment 6。
A kind of Medical cold of the present embodiment is applied ointment or plaster, and including the backing layer being sequentially connected with from top to bottom, gel layer and cover layer, described gel layer includes the raw material of following mass percent:
The auxiliary agent of the present embodiment includes glycyrrhizic acid dipotassium, water solublity Oleum menthae and menthyl lactate, it is 2% that described glycyrrhizic acid dipotassium accounts for the percentage ratio of described gel layer raw material gross mass, it is 2% that described water solublity Oleum menthae accounts for the percentage ratio of described gel layer raw material gross mass, and it is 1% that described menthyl lactate accounts for the percentage ratio of described gel layer raw material gross mass。
The polymer substance of the present embodiment is the mixture of sodium polyacrylate, carbomer, sodium alginate, sodium carboxymethyl cellulose, chitosan quaternary ammonium salt。
The wetting agent of the present embodiment is the mixture of glycerol, butanediol, Aloe Barbadensis Miller juice, sorbitol。
The backing layer of the present embodiment is non-woven fabrics backing layer, and described water is deionized water, and described cover layer is polyethylene film cover。
The ginger extract of the present embodiment is the juice being filtrated to get with 80 mesh filter screens after Rhizoma Zingiberis Recens squeezing；
Described Radix Angelicae Pubescentis extracting solution be by cleaned for Radix Angelicae Pubescentis bark, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, the medicinal liquid that obtains after concentration；
Described cortex phellodendri extract is mix with water after being pulverized by Cortex Phellodendri, first adds cellulase and carries out enzymolysis processing, then carries out decocting extraction, filtering, gained supernatant dehydrated alcohol precipitates, and refilters, gained supernatant is removed dehydrated alcohol the medicinal liquid obtained with mixed with propylene glycol。
The Herba Violae extracting solution of the present embodiment be Herba Violae is cleaned, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, the medicinal liquid that obtains after concentration；
Described Fructus Forsythiae extracting solution, for being cleaned by Fructus Forsythiae, dry, being ground into coarse powder, carries out continuous circumfluence extraction with water, 30% ethanol, 50% ethanol, 70% ethanol, 95% ethanol respectively, and extracting solution is condensed into the medicinal liquid being equivalent to crude drug 1mg/ml；
Described Indigo Naturalis powder is the powder that Indigo Naturalis is filtrated to get with 100 eye mesh screens after pulverizing。
The preparation method that a kind of Medical cold is applied ointment or plaster, including following procedure of processing:
Step A, weigh each raw material according to the formula of gel layer, standby；
Step B, polymer substance is added part water, make polymer substance swelling, obtain the swelling body of macromolecule, standby；
Step C, menthyl lactate is dissolved in ethanol, obtains the alcoholic solution of menthyl lactate, standby；
Step D, water solublity Oleum menthae, wetting agent, ginger extract, Radix Angelicae Pubescentis extracting solution, cortex phellodendri extract, Herba Violae extracting solution, Fructus Forsythiae extracting solution, Indigo Naturalis powder, glycyrrhizic acid dipotassium are added in part water, stir, obtain mixed liquor；
Step E, the alcoholic solution of swelling for macromolecule body and menthyl lactate is joined in mixed liquor, add excess water and regulate viscosity, stir, namely obtain gel；
Step F, being spread evenly across by gel on non-woven fabrics backing layer, press polyethylene film and cover, namely packaging obtains Medical cold and applies ointment or plaster finished product。
Use the present invention Medical cold apply ointment or plaster the cooling done bring down a fever test and cold compress physical therapy test:
Carry out Medical cold of the present invention in Dongguan City hospital to apply ointment or plaster Clinical observation, carried out the heating fever case of 120 person-times and carried out the bring down a fever congestion of test and 80 person-times of cold compress patch and swell and ache the test of cold compress physical therapy of symptom。Result of the test of bringing down a fever is: obvious number of quickly bringing down a fever is 117 people, and 3 people phenomenon of bringing down a fever is inconspicuous。Obvious number of lowering the temperature after 1 hour in experimenter is 98 people, and obvious number of lowering the temperature after using 3 hours is 16 people, and 3 people effect of bringing down a fever is slight。Cold compress physical therapy result of the test is: the number that pain substantially weakens is 80 people, and the number that congestion swelling symptom substantially disappears is 78 people, and 2 people's congestion swelling are disappeared inconspicuous。
Mr. Lin, man, 25 years old, affection of exogenous wind-cold, feveret 37.5 degree, after using Medical cold of the present invention to apply ointment or plaster 1 hour, body temperature was decreased obviously, and after using 1 hour, temperature recovery is normal。
Ms Zhang, female, 35 years old, affection of exogenous wind-cold, moderate was had a fever 38 degree, and after using Medical cold of the present invention to apply ointment or plaster 1 hour, body temperature reduces to 37.3 degree, and after using 3 hours, temperature recovery is normal。
Mrs Lu, female, 50 years old, cold, fever symptom, after using Medical cold of the present invention to apply ointment or plaster 2 hours, fever phenomenon disappeared。
Mr. Wu, man, 40 years old, the heating paresthesia that pharyngolaryngitis causes, after using Medical cold of the present invention to apply ointment or plaster 3 hours, temperature recovery was normal。
Little Mo, man, 4 years old, have a fever 38.5 degree, phenomenon is vomitted in the appearance that has side effects after taking medicine, and after using Medical cold of the present invention to apply ointment or plaster 1 hour, body temperature is decreased obviously, and after using 5 hours, temperature recovery is normally and without allergic stimulated phenomenon。
Xiao Zhao, female, 10 years old, regular cat fever, after using Medical cold of the present invention to apply ointment or plaster 2 hours, temperature recovery was normal, it does not have untoward reaction occur。
Mr. Huang, man, 20 years old, cause ankle arthralgia and congestion swelling owing to turning round to ankle, after using Medical cold of the present invention to apply ointment or plaster, pain substantially weakens, and uses 3 days continuously, and the congestion after applying that feels cold every day 2 times, each 6 hours substantially dissipates, and swelling degree substantially disappears。
Mr. Wu, man, 35 years old, due to contusion arm of falling, cause arm swelling congestion, use this Medical cold to apply ointment or plaster continuously 3 days, every day 2 times, swelling congestion transference cure after the cold compress of each 6 hours。
Mrs Lu, female, 26 years old, owing to wrist dislocation causes wrist swelling pain, use this Medical cold to apply ointment or plaster continuously 2 days, every day 2 times, swelling transference cure after each 6 hours cold compress。
Mr. Zhang, man, 65 years old, owing to arthritis causes arthralgia, after using this Medical-use cold compress exchange premium row cold compress, pain substantially reduced, and used three days continuously, and twice daily, sense of swelling and ache after each 6 hours cold compress disappears。
Finally should be noted that; above example is only in order to illustrate technical scheme; but not limiting the scope of the invention; although having made to explain to the present invention with reference to preferred embodiment; it will be understood by those within the art that; technical scheme can be modified or equivalent replacement, without deviating from the spirit and scope of technical solution of the present invention。
Claims (10)
1. a Medical cold is applied ointment or plaster, it is characterised in that: including the backing layer, gel layer and the cover layer that are sequentially connected with from top to bottom, described gel layer includes the raw material of following mass percent:
2. a kind of Medical cold according to claim 1 is applied ointment or plaster, it is characterised in that: described gel layer includes the raw material of following mass percent:
3. a kind of Medical cold according to claim 1 is applied ointment or plaster, it is characterised in that: described gel layer includes the raw material of following mass percent:
4. a kind of Medical cold according to claim 1 is applied ointment or plaster, it is characterized in that: described auxiliary agent includes glycyrrhizic acid dipotassium, water solublity Oleum menthae and menthyl lactate, it is 0.1～2% that described twenty oxalic acid dipotassium accounts for the percentage ratio of described gel layer raw material gross mass, it is 0.05～3% that described water solublity Oleum menthae accounts for the percentage ratio of described gel layer raw material gross mass, and it is 0.1～4% that described menthyl lactate accounts for the percentage ratio that described gel layer raw material always measures just。
5. a kind of Medical cold according to claim 1 is applied ointment or plaster, it is characterised in that: described polymer is one or more mixture of sodium polyacrylate, carbomer, sodium alginate, sodium carboxymethyl cellulose, chitosan quaternary ammonium salt just。
6. a kind of Medical cold according to claim 1 is applied ointment or plaster, it is characterised in that: described wetting agent is one or more mixture of glycerol, butanediol, Aloe Barbadensis Miller juice, sorbitol。
7. a kind of Medical cold according to claim 1 is applied ointment or plaster, it is characterised in that: described backing layer is non-woven fabrics backing layer, and described water is deionized water, and described cover layer is polyethylene film cover。
8. a kind of Medical cold according to claim 1 is applied ointment or plaster, it is characterised in that: described ginger extract is the juice being filtrated to get with 80 mesh filter screens after Rhizoma Zingiberis Recens squeezing；
Described Radix Angelicae Pubescentis extracting solution be by cleaned for Radix Angelicae Pubescentis bark, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, the medicinal liquid that obtains after concentration；
Described cortex phellodendri extract is mix with water after being pulverized by Cortex Phellodendri, first adds cellulase and carries out enzymolysis processing, then carries out decocting extraction, filtering, gained supernatant dehydrated alcohol precipitates, and refilters, gained supernatant is removed dehydrated alcohol the medicinal liquid obtained with mixed with propylene glycol。
9. a kind of Medical cold according to claim 1 is applied ointment or plaster, it is characterised in that: described Herba Violae extracting solution be Herba Violae is cleaned, dry, pulverize, add water, ultrasonic extraction, clarification, filtration, the medicinal liquid that obtains after concentration；
Described Fructus Forsythiae extracting solution, for being cleaned by Fructus Forsythiae, dry, being ground into coarse powder, carries out continuous circumfluence extraction with water, 30% ethanol, 50% ethanol, 70% ethanol, 95% ethanol respectively, and extracting solution is condensed into the medicinal liquid being equivalent to crude drug 1mg/ml；
Described Indigo Naturalis powder is the powder that Indigo Naturalis is filtrated to get with 100 eye mesh screens after pulverizing。
10. the preparation method that a kind of Medical cold as described in claim 1-9 any one is applied ointment or plaster, it is characterised in that: include following procedure of processing:
Step A, weigh each raw material according to the formula of gel layer, standby；
Step B, polymer is added just part water, make polymer substance swelling, obtain the swelling body of macromolecule, standby；
Step C, menthyl lactate is dissolved in ethanol, obtains the alcoholic solution of menthyl lactate, standby；
Step D, water solublity Oleum menthae, wetting agent, ginger extract, Radix Angelicae Pubescentis extracting solution, cortex phellodendri extract, Herba Violae extracting solution, Fructus Forsythiae extracting solution, Indigo Naturalis powder, twenty oxalic acid dipotassium are added in part water, stir, obtain mixed liquor；
Step E, the alcoholic solution of swelling for macromolecule body and menthyl lactate is joined in mixed liquor, add excess water and regulate viscosity, stir, namely obtain gel；
Step F, being spread evenly across by gel on non-woven fabrics backing layer, press polyethylene film and cover, namely packaging obtains Medical cold and applies ointment or plaster finished product。
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| CN104784653A (en) * | 2014-01-17 | 2015-07-22 | 佛山市盛世泰康医药科技有限公司 | Defervesce plaster with dual cooling defervesce efficacies of physical cooling and absorption defervesce, and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104784653A (en) * | 2014-01-17 | 2015-07-22 | 佛山市盛世泰康医药科技有限公司 | Defervesce plaster with dual cooling defervesce efficacies of physical cooling and absorption defervesce, and preparation method thereof |
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| CN106883462A (en) * | 2017-03-28 | 2017-06-23 | 成都仁天医疗器械有限公司 | A kind of cold-storage gel and preparation method thereof and cold compress patch |
| CN107157645A (en) * | 2017-03-28 | 2017-09-15 | 苏州仁耀医疗器械有限公司 | A kind of novel and multifunctional cold compress patch |
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| CN109464316A (en) * | 2019-01-07 | 2019-03-15 | 广州市拓瑞科技有限公司 | Skin conditioning composition, Medical cold application with antiallergic anti-inflammatory effect and preparation method thereof |
| CN109568004A (en) * | 2019-01-31 | 2019-04-05 | 浙江金壳医疗科技有限公司 | A kind of Medical cold application and preparation method thereof |
| CN109820637A (en) * | 2019-03-04 | 2019-05-31 | 广州市华晟健康产业有限公司 | One kind having the effect of long-acting moisturizing property Medical-use cold compress pad pasting |
| CN110075343A (en) * | 2019-05-17 | 2019-08-02 | 江苏西宏生物医药有限公司 | Medical reparation skin cold compress patch of one kind and preparation method thereof |
| CN110974941A (en) * | 2019-11-05 | 2020-04-10 | 江苏普罗诺生物科技有限公司 | Technological formula of medical cold compress physiotherapy plaster |
| CN112870257A (en) * | 2021-02-05 | 2021-06-01 | 黄秀君 | Cough-relieving medical cold compress patch and use method thereof |
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Application publication date: 20160622 |