CN101642518B

CN101642518B - Plaster for treating dysmenorrhea

Info

Publication number: CN101642518B
Application number: CN2009101169444A
Authority: CN
Inventors: 李跃
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-05-31
Filing date: 2009-05-31
Publication date: 2011-06-29
Anticipated expiration: 2029-05-31
Also published as: CN101642518A

Abstract

The invention relates to a plaster for treating dysmenorrhea, which is prepared from the following raw materials: sesame oil, yellow lead, red peony root, peony bark, rhizoma cyperi, white mustard seed, licorice, honeysuckle, baikal skullcap root, artemisia leaf, eupolyphaga sinensis, angelica, safflower, Chinese honeylocust fruit, azone and nano ceramic powder. The preparation method comprises the following contents: preparing an ointment substrate by the sesame oil and the yellow lead; after decocting other medicine materials with water, taking decoction, removing residues, concentrating the obtained medicine decoction and obtaining a medicine material extract; after dissolving the ointment substrate, adding the medicine material extract, the nano ceramic powder and the azone to obtain the ointment; and spreading the ointment on a backing material so as to obtain the plaster. The plaster for treating dysmenorrhea, which is provided by the invention, has the characteristics of accurate application, strong permeability and high content of effective components and has better curative effect for treating dysmenorrhea.

Description

The plaster that is used for the treatment of dysmenorrhea

Technical field

The present invention relates to a kind of plaster that is used for the treatment of dysmenorrhea.

Background technology

At present, adopt oral drugs or transfusion to treat usually to dysmenorrhea in clinical, oral medicine stimulates bigger to gastrointestinal, and the patient is difficult to stand, and transfusion then can have in various degree damage to liver, kidney.The result of use of the more existing plaster that is used for the treatment of dysmenorrhea is also not ideal enough, and its main cause is: material choice inadequately accurately, the active constituent content permeability low, plaster in the plaster is not good.

Summary of the invention

The object of the present invention is to provide a kind of plaster that is used for the treatment of dysmenorrhea, accurate and effective component content height of these plaster materials and good penetrability.

For achieving the above object, adopt following scheme:

The present invention the plaster that is used for the treatment of dysmenorrhea that provides is provided is made by the following dosage proportion raw material: Oleum sesami 1550～1650 grams, Plumbum preparatium 1050～1100 grams, Radix Paeoniae Rubra 5～10 grams, Cortex Moutan 10～20 grams, Rhizoma Cyperi 15～25 grams, Semen Sinapis Albae 10～20 grams, Radix Glycyrrhizae 15～25 grams, Flos Lonicerae 23～33 grams, Radix Scutellariae 30～40 grams, Folium Artemisiae Argyi 15～25 grams, Eupolyphaga Seu Steleophaga 15～25 grams, Radix Angelicae Sinensis 30～40 grams, Flos Carthami 15～25 grams, Fructus Gleditsia 20～30 grams, 15～25 milliliters of azones, nano-ceramic powder 15～25 grams.

The preparation method of plaster that is used for dysmenorrhea provided by the invention is: Oleum sesami is tempered, when oily temperature reaches 320～330 ℃, Plumbum preparatium is added, after treating that Plumbum preparatium and Oleum sesami are combined to paste, cream is poured in the cold water slowly, make cream in water, be cooled to band shape, after treating that cream condenses, taking-up was soaked in water 7 after pinching pressure, during, change water every day once, change water at every turn and all cream is pinched pressure, obtain ointment substrate; After Radix Paeoniae Rubra, Cortex Moutan, Rhizoma Cyperi, Semen Sinapis Albae, Radix Glycyrrhizae, Flos Lonicerae, Radix Scutellariae, Folium Artemisiae Argyi, Eupolyphaga Seu Steleophaga, Radix Angelicae Sinensis, Flos Carthami, Fructus Gleditsia be soaked in water 20～30 hours, water decocts 2～3 times, decoct to liquid medicine boiling back at every turn, decocted 40～50 minutes again, each back extracting juice that decocts removes slag, then the medicine juice that obtains being merged the back concentrates, to becoming to hang the flag shape, obtain spice extractum with the sticking medicine juice that goes of Glass rod; With ointment substrate heating and melting, be cooled to 65～75 ℃, add spice extractum, nano-ceramic powder, azone then and fully mix, obtain ointment; Cream 9～10 gram beach of getting it filled are being mounted on the backing material, treat that ointment is cooled to solid after, both plaster.

The present invention is a material medicine that to be selected pointedly have curative effect to dysmenorrhea in prescription, and the 2nd, selected azone, nano-ceramic powder for use.The effect of azone, nano-ceramic powder is respectively: azone is a kind of cutaneous permeable agent, and it is added in the pharmaceutical formulation, can improve the effect that drug transdermal absorbs; Nano-ceramic powder can absorb outside energy, promotes the absorption of human body to medicine.

In the preparation method of plaster that is used for the treatment of dysmenorrhea provided by the invention,, can guarantee content of effective in the plaster, and traditional way with spice " fried endure withered " can be destroyed the many effective ingredient in the spice with the spice water boiling and extraction.

As seen the plaster that is used for the treatment of dysmenorrhea provided by the invention has the advantages that medication is accurate, penetration is strong, active constituent content is high, when it uses, by absorbing outside energy and human body heat energy, has stronger penetrating power, can infiltrate skin and subcutaneous tissue, produce resonant absorption effects, play microcirculation improvement and improve tissue metabolism's nutrition with hydrone in the human body cell, promote the effect of the absorption of inflammation exudate, and reach the effect of dispelling cold by warming the meridian, inducing menstruation to relieve menalgia, tonifying Chong and Ren channels.It has curative effect preferably to the treatment dysmenorrhea.

The specific embodiment

Further specify the present invention below in conjunction with embodiment.

Embodiment

In the present embodiment, the concrete consumption proportion that is used for the treatment of used each raw material of plaster of dysmenorrhea is: Oleum sesami 1600 grams, Plumbum preparatium 1060 grams, Radix Paeoniae Rubra 8 grams, Cortex Moutan 15 grams, Rhizoma Cyperi 20 grams, Semen Sinapis Albae 15 grams, Radix Glycyrrhizae 20 grams, Flos Lonicerae 30 grams, Radix Scutellariae 35 grams, Folium Artemisiae Argyi 20 grams, Eupolyphaga Seu Steleophaga 20 grams, Radix Angelicae Sinensis 35 grams, Flos Carthami 20 grams, Fructus Gleditsia 25 grams, 20 milliliters of azones, nano-ceramic powder 20 grams.

The preparation method of the plaster that is used for the treatment of dysmenorrhea that present embodiment provides has following concrete steps:

1, Oleum sesami is tempered, when oily temperature reaches 320～330 ℃, Plumbum preparatium is added, after treating that Plumbum preparatium and Oleum sesami are combined to paste, cream is poured in the cold water slowly, make cream in water, be cooled to band shape, after treating that cream condenses, taking-up was soaked in water 7 after pinching pressure, during, change water every day once, change water at every turn and all cream is pinched pressure, obtain ointment substrate;

2, Radix Paeoniae Rubra, Cortex Moutan, Rhizoma Cyperi, Semen Sinapis Albae, Radix Glycyrrhizae, Flos Lonicerae, Radix Scutellariae, Folium Artemisiae Argyi, Eupolyphaga Seu Steleophaga, Radix Angelicae Sinensis, Flos Carthami, Fructus Gleditsia were soaked in water 20～30 hours after, water decocts 2～3 times, amount of water is good for being higher than spice 2～3cm, decoct to liquid medicine boiling back at every turn, decocted 40～50 minutes again, each back extracting juice that decocts removes slag, then the medicine juice that obtains is merged the back and concentrate,, obtain spice extractum to becoming to hang the flag shape with the sticking medicine juice that goes of Glass rod;

3, with ointment substrate heating and melting, be cooled to 65～75 ℃, add spice extractum, nano-ceramic powder, azone then and fully mix, obtain ointment; Cream 9～10 gram beach of getting it filled are being mounted on the backing material, mount the backing material and adopt the medical no yarn adhesive plaster of desensitization, treat that ointment is cooled to solid after, both one force on;

5, the plaster that makes is packed into seal in the aluminium plastic bag.

Above-described azone, nano-ceramic powder are the commercially available prod, and azone is the standardized product that is used for pharmaceuticals industry.

In addition, this ointment should be contained in the container of sealing, places drying, the keeping of shady and cool place.

For better checking curative effect of the present invention, below contrast test by curative effect group, matched group, further specify the beneficial effect of plaster treatment dysmenorrhea provided by the invention:

1 grouping and Therapeutic Method

1.1 grouping successively is divided into treatment group and matched group with the patient at random by consultation time, 48 examples are organized in treatment, matched group 46 examples;

1.2 the treatment group uses plaster provided by the invention that the dysmenorrhea patient is treated;

1.3 matched group uses conventional chemical medicine or Chinese patent medicine (as flufenamic acid, atropine, YUANHU ZHITONG PIAN, YUEYUESHU KELI etc.) that the dysmenorrhea patient is treated;

1.4 the course of treatment, treatment group and matched group all by treatment in every month 10 days, are treated a course of treatment 3 each months continuously;

1.5 using method is affixed on umbilical part (SHENQUE acupoint) with plaster provided by the invention after with little bakingization to the treatment group, from the preceding 3 days beginnings of menstruation, finish to end in back 3 days to menstruation, paste every day one, and treating 3 menstrual cycle continuously is a course of treatment, the diet of avoiding cold and uncooked food during the treatment.

The related data of 2 treatment groups and matched group

2.1 age distribution sees Table one:

Table one

Group	The example number	Below 20 years old	21～35 years old	More than 35 years old
					The treatment group	28	15	11	2
Matched group	27	14	10	3

2.2 course of disease situation sees Table two

Table two

Group	The example number	Below 2 years	3～5 years	More than 5 years
					The treatment group	28	9	14	5
Matched group	27	8	12	7

3 efficacy assessment standards

3.1 produce effects, pain disappears, and continuous 3 menstrual cycle are not seen recurrence;

3.2 take a turn for the better, pain relief or disappearance, but can not keep more than 3 months;

3.3 invalid, pain does not have obvious alleviation.

4 result of the tests (after the course of treatment, following up a case by regular visits to 3 months) see Table three

Table three

Group	The example number	Produce effects	Take a turn for the better	Invalid	Total effective rate
						The treatment group	28	15	12	1	96.43％
Matched group	27	12	11	4	85.19％

By above test as can be seen, the plaster that is used for the treatment of dysmenorrhea provided by the invention has significant curative effect to TREATMENT OF DYSMENORRHOEA.

Claims

1. the plaster that is used for the treatment of dysmenorrhea is characterized in that it is made by the following dosage proportion raw material: Oleum sesami 1550～1650 grams, Plumbum preparatium 1050～1100 grams, Radix Paeoniae Rubra 5～10 grams, Cortex Moutan 10～20 grams, Rhizoma Cyperi 15～25 grams, Semen Sinapis Albae 10～20 grams, Radix Glycyrrhizae 15～25 grams, Flos Lonicerae 23～33 grams, Radix Scutellariae 30～40 grams, Folium Artemisiae Argyi 15～25 grams, Eupolyphaga Seu Steleophaga 15～25 grams, Radix Angelicae Sinensis 30～40 grams, Flos Carthami 15～25 grams, Fructus Gleditsia 20～30 grams, 15～25 milliliters of azones, nano-ceramic powder 15～25 grams.

2. the plaster that is used for the treatment of dysmenorrhea according to claim 1 is characterized in that the consumption proportion of each raw material is: Oleum sesami 1600 grams, Plumbum preparatium 1060 grams, Radix Paeoniae Rubra 8 grams, Cortex Moutan 15 grams, Rhizoma Cyperi 20 grams, Semen Sinapis Albae 15 grams, Radix Glycyrrhizae 20 grams, Flos Lonicerae 30 grams, Radix Scutellariae 35 grams, Folium Artemisiae Argyi 20 grams, Eupolyphaga Seu Steleophaga 20 grams, Radix Angelicae Sinensis 35 grams, Flos Carthami 20 grams, Fructus Gleditsia 25 grams, 20 milliliters of azones, nano-ceramic powder 20 grams.

3. described preparation method that is used for the treatment of the plaster of dysmenorrhea of claim 1, it is characterized in that may further comprise the steps: Oleum sesami is tempered, when oily temperature reaches 320～330 ℃, Plumbum preparatium is added, treat that Plumbum preparatium and Oleum sesami are combined to paste after, slowly pour into cream in the cold water, make cream in water, be cooled to band shape, treat that cream condenses after, take out and to be soaked in water 7 after pinching pressure, during this time, change water every day once, change water at every turn and all cream is pinched pressure, obtain ointment substrate; After Radix Paeoniae Rubra, Cortex Moutan, Rhizoma Cyperi, Semen Sinapis Albae, Radix Glycyrrhizae, Flos Lonicerae, Radix Scutellariae, Folium Artemisiae Argyi, Eupolyphaga Seu Steleophaga, Radix Angelicae Sinensis, Flos Carthami, Fructus Gleditsia be soaked in water 20～30 hours, water decocts 2～3 times, each back extracting juice that decocts removes slag, and then the medicine juice that obtains is merged the back and concentrates, and obtains spice extractum; With ointment substrate heating and melting, add spice extractum, nano-ceramic powder, azone then and fully mix, obtain ointment; The cream of getting it filled stand is coated in mounts on the backing material, treat that ointment is cooled to solid after, promptly get plaster.