CN101642544B

CN101642544B - Plaster for treating chronic pelvic inflammation

Info

Publication number: CN101642544B
Application number: CN2009101169478A
Authority: CN
Inventors: 李跃
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-05-31
Filing date: 2009-05-31
Publication date: 2011-09-07
Anticipated expiration: 2029-05-31
Also published as: CN101642544A

Abstract

The invention relates to a plaster for treating chronic pelvic inflammation, which is prepared from the following raw materials: sesame oil, yellow lead, angelica, rhizoma ligustici wallichii, rehmannia root, rhizoma cyperi, turmeric, dandelion, spina gleditsiae, white mustard seed, rhizoma zedoariae, honeysuckle, white peony root, peony bark, licorice, draconis sanguis, safflower, azone and nanoceramic powder. The preparation method comprises the following contents: preparing an ointment substrate by the sesame oil and the yellow lead; pulverizing the draconis sanguis into powder which is sieved by a sieve of 110 meshes and obtaining medicine material powder for standby; after decocting other medicine materials with water, taking decoction, removing residues, concentrating the obtained medicine decoction and obtaining a medicine material extract; after dissolving the ointment substrate, adding the medicine material extract, the medicine material powder, the nano ceramic powder and the azone to obtain the ointment; and spreading the ointment on a backing material so as to obtain the plaster. The plaster for treating the chronic pelvic inflammation, which is provided by the invention, has the characteristics of accurate application, strong permeability and high content of effective components and has better curative effect for treating the chronic pelvic inflammation.

Description

The plaster that is used for the treatment of chronic pelvic inflammatory disease

Technical field

The present invention relates to a kind of plaster that is used for the treatment of chronic pelvic inflammatory disease.

Background technology

At present, adopt oral drugs or transfusion to treat usually to chronic pelvic inflammatory disease in clinical, oral medicine stimulates bigger to gastrointestinal, and the patient is difficult to stand, and transfusion then can have in various degree damage to liver, kidney.The result of use of the more existing plaster that is used for the treatment of chronic pelvic inflammatory disease is also not ideal enough, and its main cause is: material choice inadequately accurately, the active constituent content permeability low, plaster in the plaster is not good.

Summary of the invention

The object of the present invention is to provide a kind of plaster that is used for the treatment of chronic pelvic inflammatory disease, accurate and effective component content height of these plaster materials and good penetrability.

For achieving the above object, adopt following scheme:

The present invention the plaster that is used for the treatment of chronic pelvic inflammatory disease that provides is provided is made by the following dosage proportion raw material: Oleum sesami 1550～1650 grams, Plumbum preparatium 1050～1100 grams, Radix Angelicae Sinensis 15～25 grams, Rhizoma Chuanxiong 20～30 grams, the Radix Rehmanniae 30～40 grams, Rhizoma Cyperi 30～40 grams, Radix Curcumae 40～50 grams, Herba Taraxaci 50～60 grams, Spina Gleditsiae 80～90 grams, Semen Sinapis Albae 18～28 grams, Rhizoma Curcumae 30～40 grams, Flos Lonicerae 28～38 grams, the Radix Paeoniae Alba 35～45 grams, Cortex Moutan 50～60 grams, Radix Glycyrrhizae 18～28 grams, Sanguis Draxonis 22～32 grams, Flos Carthami 16～26 grams, 10～20 milliliters of azones, nano-ceramic powder 10～20 grams.

The preparation method of plaster that is used for chronic pelvic inflammatory disease provided by the invention is: Oleum sesami is tempered, when oily temperature reaches 320～330 ℃, Plumbum preparatium is added, after treating that Plumbum preparatium and Oleum sesami are combined to paste, cream is poured in the cold water slowly, make cream in water, be cooled to band shape, after treating that cream condenses, taking-up was soaked in water 7 after pinching pressure, during, change water every day once, change water at every turn and all cream is pinched pressure, obtain ointment substrate; Sanguis Draxonis powder was broken into the powder of 110 mesh sieves, and it is standby to obtain the spice powder; After Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Rehmanniae, Rhizoma Cyperi, Radix Curcumae, Herba Taraxaci, Spina Gleditsiae, Semen Sinapis Albae, Rhizoma Curcumae, Flos Lonicerae, the Radix Paeoniae Alba, Cortex Moutan, Radix Glycyrrhizae, Flos Carthami be soaked in water 20～30 hours, water decocts 2～3 times, each back extracting juice that decocts removes slag, then the medicine juice that obtains is merged the back and concentrate, obtain spice extractum; With ointment substrate heating and melting, add spice extractum, spice powder, nano-ceramic powder, azone then and fully mix, obtain ointment; The cream beach of getting it filled is being mounted on the backing material, treat that ointment is cooled to solid after, both plaster.

The present invention is a material medicine that to be selected pointedly have curative effect to chronic pelvic inflammatory disease in prescription, and the 2nd, selected azone, nano-ceramic powder for use.The effect of azone, nano-ceramic powder is respectively: azone is a kind of cutaneous permeable agent, and it is added in the pharmaceutical formulation, can improve the effect that drug transdermal absorbs; Nano-ceramic powder can absorb outside energy, promotes the absorption of human body to medicine.

In the preparation method of plaster that is used for the treatment of chronic pelvic inflammatory disease provided by the invention,, can guarantee content of effective in the plaster, and traditional way with spice " fried endure withered " can be destroyed the many effective ingredient in the spice with the spice water boiling and extraction.

As seen the plaster that is used for the treatment of chronic pelvic inflammatory disease provided by the invention has the advantages that medication is accurate, penetration is strong, active constituent content is high, when it uses, by absorbing outside energy and human body heat energy, has stronger penetrating power, can infiltrate skin and subcutaneous tissue, produce resonant absorption effects with hydrone in the human body cell, play microcirculation improvement and improve tissue metabolism's nutrition, promote the effect of the absorption of inflammation exudate, and reach that removing damp-heat, blood stasis-eliminating and stagnation-dissipating, warming the spleen kidney, cold expelling coagulate, are transferred to, the effect of dai channel.It has curative effect preferably to the treatment chronic pelvic inflammatory disease.

The specific embodiment

Further specify the present invention below in conjunction with embodiment.

Embodiment

In the present embodiment, the concrete consumption proportion that is used for the treatment of used each raw material of plaster of chronic pelvic inflammatory disease is: Oleum sesami 1600 grams, Plumbum preparatium 1060 grams, Radix Angelicae Sinensis 20 grams, Rhizoma Chuanxiong 25 grams, the Radix Rehmanniae 35 grams, Rhizoma Cyperi 35 grams, Radix Curcumae 45 grams, Herba Taraxaci 55 grams, Spina Gleditsiae 85 grams, Semen Sinapis Albae 25 grams, Rhizoma Curcumae 35 grams, Flos Lonicerae 35 grams, the Radix Paeoniae Alba 40 grams, Cortex Moutan 55 grams, Radix Glycyrrhizae 25 grams, Sanguis Draxonis 25 grams, Flos Carthami 23 grams, 15 milliliters of azones, nano-ceramic powder 15 grams.

The preparation method of bumping noticeable plaster that is used for the treatment of that present embodiment provides has following concrete steps:

1, Oleum sesami is tempered, when oily temperature reaches 320～330 ℃, Plumbum preparatium is added, after treating that Plumbum preparatium and Oleum sesami are combined to paste, cream is poured in the cold water slowly, make cream in water, be cooled to band shape, after treating that cream condenses, taking-up was soaked in water 7 after pinching pressure, during, change water every day once, change water at every turn and all cream is pinched pressure, obtain ointment substrate;

2, Sanguis Draxonis powder was broken into the powder of 110 mesh sieves, it is standby to obtain the spice powder;

3, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Rehmanniae, Rhizoma Cyperi, Radix Curcumae, Herba Taraxaci, Spina Gleditsiae, Semen Sinapis Albae, Rhizoma Curcumae, Flos Lonicerae, the Radix Paeoniae Alba, Cortex Moutan, Radix Glycyrrhizae, Flos Carthami were soaked in water 20～30 hours after, water decocts 2～3 times, amount of water is good for being higher than spice 2～3cm, decoct to liquid medicine boiling back at every turn, decocted 40～50 minutes again, each back extracting juice that decocts removes slag, then the medicine juice that obtains is merged the back and concentrate,, obtain spice extractum to becoming to hang the flag shape with the sticking medicine juice that goes of Glass rod;

3, with ointment substrate heating and melting, be cooled to 65～75 ℃, add spice extractum, spice powder, nano-ceramic powder, azone then and fully mix, obtain ointment; Cream 9～10 gram beach of getting it filled are being mounted on the backing material, mount the backing material and adopt the medical no yarn adhesive plaster of desensitization, treat that ointment is cooled to solid after, both one force on;

5, the plaster that makes is packed into seal in the aluminium plastic bag.

Above-described azone, nano-ceramic powder are the commercially available prod, and azone is the standardized product that is used for pharmaceuticals industry.

In addition, this ointment should be contained in the container of sealing, places drying, the keeping of shady and cool place.

For better checking curative effect of the present invention, below contrast test by curative effect group, matched group, further specify the beneficial effect of plaster treatment chronic pelvic inflammatory disease provided by the invention:

1 grouping and Therapeutic Method

1.1 grouping successively is divided into treatment group and matched group with the patient at random by consultation time, 91 examples are organized in treatment, matched group 88 examples;

1.2 the treatment group uses plaster provided by the invention that undergoing chronic pelvic inflammation is treated;

1.3 matched group uses conventional chemical medicine or Chinese patent medicine (as penicillin, cefalexin, tinidazole, FUKE QIANJIN PIAN, FUYANNING JIAONANG etc.) that undergoing chronic pelvic inflammation is treated;

1.4 the course of treatment, treatment group and matched group were a course of treatment in equal 10 days;

1.5 using method is main person with hypogastric region bitterly, with this plaster with little bakingization after, respectively stick subsides in SHENQUE acupoint, the cave of coming back, water channel cave, and, can increase therapeutic effect with hot water bag hot compress umbilical part; With waist is main person bitterly, respectively sticks subsides in the gate of vitality, shen shu, chi hai shu, yao yang kuan cave; Weighing down pain with the waist sacrum is main person, close Yu, pang kuang shu, on wine with dregs, inferior wine with dregs cave respectively stick subsides; The obvious person of inflammatory mass sticks on the enclosed mass place; The adnexa person of thickening, pressure pain or pain are obviously located; Once a day, each 6～10 hours, 12 times was a course of treatment.

The related data of 2 treatment groups and matched group

2.1 age distribution sees Table one:

Table one

Group	The example number	20～35 years old	36～49 years old	50～60 years old	More than 60 years old
						The treatment group	91	35	46	7	3
Matched group	88	31	48	8	1

2.2 course of disease situation sees Table two

Table two

Group	The example number	Below 2 years	3～5 years	6～10 years	More than 10 years
						The treatment group	91	10	32	45	4
Matched group	88	11	35	40	2

2.3 ailing position sees Table three

Table three

Group	The example number	The hypogastric region pain	Waist pain, waist sacrum weigh down pain	Adnexa thickens	Inflammatory mass
						The treatment group	91	10	31	22	28
Matched group	88	11	29	27	21

3 efficacy assessment standards

3.1 cure, clinical symptoms and sign disappear, ultrasound diagnosis is normal;

3.2 produce effects, clinical symptoms takes a turn for the better to some extent, and the ultrasound diagnosis inflammatory mass dwindles more than 2/3;

3.3 effectively, clinical symptoms takes a turn for the better to some extent, the ultrasound diagnosis inflammatory mass dwindles more than 1/2, with mild tenderness;

3.4 invalid, clinical symptoms and sign do not have significant change, even increase the weight of.

4 result of the tests (after 2 courses of treatment) see Table four

Table four

Group	The example number	Cure	Produce effects	Effectively	Invalid	Total effective rate
							The treatment group	91	5	28	52	6	93.41％
Matched group	88	4	18	54	12	86.36％

By above contrast test and result as can be seen, plaster provided by the invention has significant curative effect to the treatment chronic diarrhea of chronic diarrhea.

Claims

1. the plaster that is used for the treatment of chronic pelvic inflammatory disease, it is characterized in that, make: Oleum sesami 1550～1650 grams by the following dosage proportion raw material, Plumbum preparatium 1050～1100 grams, Radix Angelicae Sinensis 15～25 grams, Rhizoma Chuanxiong 20～30 grams, the Radix Rehmanniae 30～40 grams, Rhizoma Cyperi 30～40 grams, Radix Curcumae 40～50 grams, Herba Taraxaci 50～60 grams, Spina Gleditsiae 80～90 grams, Semen Sinapis Albae 18～28 grams, Rhizoma Curcumae 30～40 grams, Flos Lonicerae 28～38 grams, the Radix Paeoniae Alba 35～45 grams, Cortex Moutan 50～60 grams, Radix Glycyrrhizae 18～28 grams, Sanguis Draxonis 22～32 grams, Flos Carthami 16～26 grams, 10～20 milliliters of azones, nano-ceramic powder 10～20 grams; Its preparation method may further comprise the steps: Oleum sesami is tempered, when oily temperature reaches 320～330 ℃, Plumbum preparatium is added, after treating that Plumbum preparatium and Oleum sesami are combined to paste, cream is poured in the cold water slowly, make cream in water, be cooled to band shape, after treating that cream condenses, taking-up was soaked in water 7 after pinching pressure, during, change water every day once, change water at every turn and all cream is pinched pressure, obtain ointment substrate; Sanguis Draxonis powder was broken into the powder of 110 mesh sieves, and it is standby to obtain the spice powder; After Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Rehmanniae, Rhizoma Cyperi, Radix Curcumae, Herba Taraxaci, Spina Gleditsiae, Semen Sinapis Albae, Rhizoma Curcumae, Flos Lonicerae, the Radix Paeoniae Alba, Cortex Moutan, Radix Glycyrrhizae, Flos Carthami be soaked in water 20～30 hours, water decocts 2～3 times, each back extracting juice that decocts removes slag, then the medicine juice that obtains is merged the back and concentrate, obtain spice extractum; With ointment substrate heating and melting, add spice extractum, spice powder, nano-ceramic powder, azone then and fully mix, obtain ointment; The cream beach of getting it filled is being mounted on the backing material, treat that ointment is cooled to solid after, promptly get plaster.

2. the plaster that is used for the treatment of chronic pelvic inflammatory disease according to claim 1 is characterized in that the consumption proportion of each raw material is: Oleum sesami 1600 grams, Plumbum preparatium 1060 grams, Radix Angelicae Sinensis 20 grams, Rhizoma Chuanxiong 25 grams, the Radix Rehmanniae 35 grams, Rhizoma Cyperi 35 grams, Radix Curcumae 45 grams, Herba Taraxaci 55 grams, Spina Gleditsiae 85 grams, Semen Sinapis Albae 25 grams, Rhizoma Curcumae 35 grams, Flos Lonicerae 35 grams, the Radix Paeoniae Alba 40 grams, Cortex Moutan 55 grams, Radix Glycyrrhizae 25 grams, Sanguis Draxonis 25 grams, Flos Carthami 23 grams, 15 milliliters of azones, nano-ceramic powder 15 grams.