CN106691669A - Antipyretic gel and roll-on device thereof - Google Patents

Antipyretic gel and roll-on device thereof Download PDF

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Publication number
CN106691669A
CN106691669A CN201611089922.XA CN201611089922A CN106691669A CN 106691669 A CN106691669 A CN 106691669A CN 201611089922 A CN201611089922 A CN 201611089922A CN 106691669 A CN106691669 A CN 106691669A
Authority
CN
China
Prior art keywords
antipyretic gel
antipyretic
mixing
gel
ball
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201611089922.XA
Other languages
Chinese (zh)
Inventor
王海波
曾慧
王中元
余志敏
黄强
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bingbing Pharmaceutical Co., Ltd., Wuhan
Original Assignee
Hubei Silicon Energy Saving Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hubei Silicon Energy Saving Technology Co Ltd filed Critical Hubei Silicon Energy Saving Technology Co Ltd
Priority to CN201611089922.XA priority Critical patent/CN106691669A/en
Publication of CN106691669A publication Critical patent/CN106691669A/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0087—Hand-held applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F2007/0203—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor
    • A61F2007/0215—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor containing liquids other than water
    • A61F2007/0219—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/04—Skin

Abstract

The invention discloses an antipyretic gel and roll-on device thereof. The antipyretic gel is prepared from, by mass, substrate gel 1-10%, moisturizer20-40%, penetration enhancers1-5%, stabilizer 0-5%, seltzer 0-5%, PH modifier0.3-5%, preservative 0-5%, wetting agent 0.3-10%, and solvent 40-65%. The antipyretic gel is made from stored energy high polymer material, soft and transparent, which has the advantages of cooling storage, lowing the temperature, being safe and non-stimulation, and no any side effects. The roll-on device thereof comprises a bottle body with an opening on the top, ball bearing components at the opening. The ball bearing components comprise a ball seat and a ball that can roll to insert the seat partly, a cover that connects to the cylinder thread and covers ball bearing components. The bottle is filled with antipyretic gel.

Description

Antipyretic gel and the antipyretic gel ballpoint device using antipyretic gel
Technical field
The present invention relates to pharmaceutical technology field, more particularly, to a kind of antipyretic gel and the antipyretic gel using antipyretic gel Ballpoint device.
Background technology
Fever is because the effect of pyrogen makes the modulability body temperature for moving and causing on body temperature set point raise (more than 0.5 DEG C) phenomenon, it is also called heating.The reason for causing heating is a lot, most commonly infect (including various bacterium infections, virus sense Dye, mycoplasma infection etc.), next to that CTD (i.e. collagen disease), malignant tumour etc..Heating is favorably also harmful to human body. Adstante febre immune function of human body is remarkably reinforced, and is conducive to removing pathogen and promotes the recovery from illness of disease.And heating is also disease One mark, therefore, when body temperature is less high, can be reduced by drinking water more heating tape come sense of discomfort, do not surpass in body temperature The mode of Physical temperature-lowering can be as far as possible selected to control body temperature when crossing 38.5 DEG C.But can if body temperature is more than 40 DEG C (children are more than 39 DEG C) Dizzy, convulsions, shock, or even serious sequelae can be caused, therefore should be seen a doctor in time.
Physical temperature-lowering is the method absorbed heat or radiated by physics, and making the temperature of object reduces.Common Physical temperature-lowering side Formula has：1. soak：Including hot compress and cold compress, its operation is to immerse in warm water or cold water towel, is wrung out after being impregnated with, and uses it Wipe or spread on the positions such as forehead, arteria carotis, armpit, elbow nest, the palm of the hand, groin, knee nest, arch of the foot.The method is simple Effectively, but there is also following shortcoming：Some positions are unfavorable for that towel is applied, such as knee nest, arteria carotis；Some area skins are thin It is tender, repeatedly wipe and be likely to result in skin injury so as to increase infected risk, such as groin, armpit；The method needs repeatedly sudden and violent Dew body, misoperation is put into and patient can be made to suffer from cold cause aggravation.2. alcohol wipe：The towelette of gauze or softness is used 25%-50% wine alcohol dips in wet, is screwed onto half-dried neck, chest, oxter, four limbs, the trick heart for gently wiping patient.Although alcohol Evaporation is more easy to than water, but lowering the temperature too fast may make patient not feel well；Alcohol has certain excitant, and large area uses alcohol meeting Patient is sucked alcohol steam even via skin absorption alcohol, be unfavorable for Rehabilitation；The alcohol of high concentration can stimulate skin, Absorb epidermis large quantity of moisture and cause skin injury.
The content of the invention
It is an object of the invention to overcome above-mentioned technical deficiency, propose that one kind has efficient cold storage cooling and safety is not pierced Sharp, antipyretic gel without any side effects and the antipyretic gel ballpoint device using antipyretic gel.
To reach above-mentioned technical purpose, technical scheme provides a kind of antipyretic gel, and it is wrapped by mass percentage Include following component：
Preferably, described gel-type vehicle is shitosan, propane diols, xanthans, polyethylene glycol, polyvinyl alcohol, methyl fibre Dimension element, ethyl cellulose, microcrystalline cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, Hydroxypropyl methylcellulose, carboxymethyl cellulose The mixing of any one or more in plain sodium.
Preferably, described NMF is any one or more in glycerine, propane diols, sorbierite, polyethylene glycol Mixing.
Preferably, described penetrating agent is propane diols, glycerine, oleic acid, Liquid Macrogol, PEG400, low molecule Two or more mixing in alcohols, azone, urea, menthol, camphor, borneol, eucalyptus oil, selinum oil.
Preferably, described stabilizer is metal-chelator disodium ethylene diamine tetraacetate, tetrasodium ethylenediamine tetraacetate, second two Any one in amine tetraacethyl dicalcium.
Preferably, described solubilizer be TWEEN Series, Span series, lauryl sodium sulfate, PEG- rilanit specials, The mixing of any one or more in Crodaret.
Preferably, described PH conditioning agents are citric acid, sorbic acid, triethanolamine, NaOH, ammoniacal liquor, sodium acid carbonate In the mixing of any one or more.
Preferably, described preservative is chloreresol, sodium sorbate, anesin, methyl hydroxybenzoate, nipalgin second The mixing of any one or more in ester, propylben, sulphite, cysteine.
Preferably, described wetting agent be ethanol, dimethyl sulfoxide, polyoxyethylene-type surfactant in any one or Various mixing.
Preferably, the solvent is deionized water.
Preferably, the antipyretic gel includes following component by mass percentage：
Gel-type vehicle：Microcrystalline cellulose 0.1~10%, xanthans 0.1~10%, hydroxyethyl cellulose 0.1~10%, carboxylic Sodium carboxymethylcellulose pyce 0.1~10%；
NMF：Glycerine 0.5~40%, propane diols 0.5~40%；
Wetting agent：Ethanol 0.5~10%；
Solubilizer：Cremophor RH40 0.1~5%；
Penetrating agent：Borneol 0~2%, eucalyptus oil 0~2%, menthol 0~2%；
Preservative：Ethylparaben 0.1~5%；
PH conditioning agents：Triethanolamine 0.3~5%；
Stabilizer：Tetrasodium salt of EDTA 0.1%~3%；
Solvent：Deionized water 40~65%.
A kind of antipyretic gel ballpoint device, including
Top is provided with the bottle of opening,
Ball assembly at bottle opening, the ball assembly includes ball base and is rollably partially submerged into this Ball in ball base；And,
The lid of the ball assembly is threadedly coupled and covered with bottle；
Wherein, it is provided with the antipyretic gel in the bottle.
Antipyretic gel of the present invention and the antipyretic gel ballpoint device using antipyretic gel, it uses energy storage macromolecular material Kermes is formed, colloid soft and transparent shape, the special efficacy with efficient cold storage cooling；Safety does not stimulate, without any side effects；Apply Glue-line is formed after smearing and does not drop down glue with skin attachement, be suitable for any position of human body, patient compliance is good.The antipyretic gel is walked Pearl device takes the antipyretic gel in bottle out of bottle by the rolling of ball, and is easy to uniformly be coated on patient skin.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to Limit the present invention.
Embodiment 1：
Embodiments of the invention 1 provide a kind of antipyretic gel ballpoint device, including top is provided with the bottle of opening, located at bottle Ball assembly at body opening, the ball assembly includes ball base and the rolling being rollably partially submerged into the ball base Pearl；And, the lid of the ball assembly is threadedly coupled and covered with bottle；Wherein, it is provided with antipyretic gel in the bottle.
The antipyretic gel, it includes following component by mass percentage：
Gel-type vehicle：Microcrystalline cellulose 0.5%, xanthans 0.5%, hydroxyethyl cellulose 0.5%, sodium cellulose glycolate 0.1%；
NMF：Glycerine 30%, propane diols 10%；
Wetting agent：Ethanol 5%；
Solubilizer：Cremophor RH40 3%；
Penetrating agent：Borneol 0.1%, eucalyptus oil 0.1%, menthol 0.2%；
Preservative：Ethylparaben 0.3%；
PH conditioning agents：Triethanolamine 3%；
Stabilizer：Tetrasodium salt of EDTA 0.1%；
Solvent：Deionized water 46.6%.
The preparation method of the antipyretic gel includes following preparation process：
1) got the raw materials ready by following mass percent：Microcrystalline cellulose 0.5%, xanthans 0.5%, hydroxyethyl cellulose 0.5%, Sodium cellulose glycolate 0.1%, glycerine 30%, propane diols 10%, ethanol 5%, Cremophor RH40 3%, borneol 0.1%th, eucalyptus oil 0.1%, menthol 0.2%, ethylparaben 0.3%, triethanolamine 3%, tetrasodium salt of EDTA 0.1%th, deionized water 46.6%；
2) by the hydroxyethyl cellulose ethanol wet of 1/3 recipe quantity, mixture a is formed；
3) by the tetrasodium salt of EDTA deionized water dissolving of 1/10 recipe quantity, mixture b is formed；
4) mixture a, mixture b, sodium carboxymethylcellulose, xanthans are dispersed in remaining place under agitation A phases are formed in the deionized water of side's amount；
5) menthol, borneol are dissolved with remaining recipe quantity ethanol, forms mixture c；
6) microcrystalline cellulose, mixture c, Cremophor RH40, eucalyptus oil, propane diols and ethylparaben are being stirred Formation B phases in glycerine are dispersed under the conditions of mixing；
7) B phases are scattered in A phases, in the case where vacuum condition is vacuumized, stirring is formed uniformly gel in 5 minutes；
8) triethanolamine is added, is stirred, regulation gel pH value obtains antipyretic gel between 6~8.
Wherein, the gel-type vehicle described in the present embodiment be shitosan, propane diols, xanthans, polyethylene glycol, polyvinyl alcohol, Methylcellulose, ethyl cellulose, microcrystalline cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, Hydroxypropyl methylcellulose, carboxylic first The mixing of any one or more in base sodium cellulosate；
Described NMF is the mixing of any one or more in glycerine, propane diols, sorbierite, polyethylene glycol；
Described penetrating agent is propane diols, glycerine, oleic acid, Liquid Macrogol, PEG400, low molecule alcohol, nitrogen Two or more mixing in ketone, urea, menthol, camphor, borneol, eucalyptus oil, selinum oil；
Described stabilizer is metal-chelator disodium ethylene diamine tetraacetate, tetrasodium ethylenediamine tetraacetate, ethylenediamine tetrem Any one in sour dicalcium；
Described solubilizer is TWEEN Series, Span series, lauryl sodium sulfate, PEG- rilanit specials, polyoxy second The mixing of any one or more in alkene rilanit special；
Described PH conditioning agents are any in citric acid, sorbic acid, triethanolamine, NaOH, ammoniacal liquor, sodium acid carbonate One or more of mixing；
Described preservative is chloreresol, sodium sorbate, anesin, methyl hydroxybenzoate, ethylparaben, nipalgin The mixing of any one or more in propyl ester, sulphite, cysteine；
Described wetting agent is any one or more in ethanol, dimethyl sulfoxide, polyoxyethylene-type surfactant Mixing；
The solvent is deionized water.
Embodiment 2：
Embodiments of the invention 2 provide a kind of antipyretic gel ballpoint device, itself and the basic phase of the preparation method of embodiment 1 Together, difference is that the antipyretic gel of the present embodiment 2 is got the raw materials ready as following weight percent when preparing：Microcrystalline cellulose 0.1%th, xanthans 0.5%, hydroxyethyl cellulose 0.3%, sodium cellulose glycolate 1.0%, glycerine 20%, propane diols 10%, Ethanol 10%, Cremophor RH40 3%, borneol 0.5%, eucalyptus oil 0.5%, menthol 0.2%, ethylparaben 0.5%th, triethanolamine 4%, tetrasodium salt of EDTA 0.3%, deionized water 49.1%.
Embodiment 3：
Embodiments of the invention 3 provide a kind of antipyretic gel ballpoint device, itself and the basic phase of the preparation method of embodiment 1 Together, difference is that the antipyretic gel of the present embodiment 3 is got the raw materials ready as following weight percent when preparing：Microcrystalline cellulose 3%, Xanthans 2%, hydroxyethyl cellulose 3%, sodium cellulose glycolate 2%, glycerine 17%, propane diols 10%, ethanol 8%, PEG- 40 rilanit specials 5%, borneol 0.8%, eucalyptus oil 0.5%, menthol 0.3%, ethylparaben 1.0%, triethanolamine 5%th, tetrasodium salt of EDTA 0.5%, deionized water 41.9%.
Embodiment 4：
Embodiments of the invention 4 provide a kind of antipyretic gel ballpoint device, itself and the basic phase of the preparation method of embodiment 1 Together, difference is that the antipyretic gel of the present embodiment 4 is got the raw materials ready as following weight percent when preparing：Microcrystalline cellulose 0.1%th, xanthans 0.3%, hydroxyethyl cellulose 0.3%, sodium cellulose glycolate 0.3%, glycerine 10%, propane diols 10%, Ethanol 0.3%, Cremophor RH40 5%, borneol 0.5%, eucalyptus oil 0.3%, menthol 0.2%, ethylparaben 5%th, triethanolamine 0.3%, tetrasodium salt of EDTA 5%, deionized water 62.4%.
Embodiment 5：
Embodiments of the invention 5 provide a kind of antipyretic gel ballpoint device, itself and the basic phase of the preparation method of embodiment 1 Together, difference is that the antipyretic gel of the present embodiment 5 is got the raw materials ready as following weight percent when preparing：Microcrystalline cellulose 3%, Xanthans 2%, hydroxyethyl cellulose 3%, sodium cellulose glycolate 2%, glycerine 10%, propane diols 20%, ethanol 10%, PEG- 40 rilanit specials 0.1%, borneol 2%, eucalyptus oil 2%, menthol 1%, ethylparaben 0.1%, triethanolamine 5%, second Ethylene diamine tetraacetic acid tetrasodium salt 0.1%, deionized water 49.7%.
Antipyretic gel of the present invention and the antipyretic gel ballpoint device using antipyretic gel, it uses energy storage macromolecular material Kermes is formed, colloid soft and transparent shape, the special efficacy with efficient cold storage cooling；Safety does not stimulate, without any side effects；Apply Glue-line is formed after smearing and does not drop down glue with skin attachement, be suitable for any position of human body, patient compliance is good.The antipyretic gel is walked Pearl device takes the antipyretic gel in bottle out of bottle by the rolling of ball, and is easy to uniformly be coated on patient skin.
The specific embodiment of present invention described above, is not intended to limit the scope of the present invention..Any basis Various other corresponding change and deformation that technology design of the invention is made, should be included in the guarantor of the claims in the present invention In the range of shield.

Claims (10)

1. a kind of antipyretic gel, it is characterised in that by mass percentage including following component：
2. antipyretic gel according to claim 1, it is characterised in that described gel-type vehicle is shitosan, propane diols, xanthan Glue, polyethylene glycol, polyvinyl alcohol, methylcellulose, ethyl cellulose, microcrystalline cellulose, hydroxyethyl cellulose, hydroxy propyl cellulose The mixing of any one or more in element, Hydroxypropyl methylcellulose, sodium carboxymethylcellulose.
3. antipyretic gel according to claim 1, it is characterised in that described NMF be glycerine, propane diols, sorbierite, The mixing of any one or more in polyethylene glycol.
4. antipyretic gel according to claim 1, it is characterised in that described penetrating agent is propane diols, glycerine, oleic acid, poly- In ethylene glycol 300, PEG400, low molecule alcohol, azone, urea, menthol, camphor, borneol, eucalyptus oil, selinum oil Two or more mixing.
5. antipyretic gel according to claim 1, it is characterised in that described stabilizer is metal-chelator ethylenediamine tetrem Any one in acid disodium, tetrasodium ethylenediamine tetraacetate, ethylenediamine tetra-acetic acid dicalcium.
6. antipyretic gel according to claim 1, it is characterised in that described solubilizer is TWEEN Series, Span series, ten The mixing of any one or more in sodium dialkyl sulfate, PEG- rilanit specials, Crodaret.
7. antipyretic gel according to claim 1, it is characterised in that described PH conditioning agents are citric acid, sorbic acid, three second The mixing of any one or more in hydramine, NaOH, ammoniacal liquor, sodium acid carbonate.
8. antipyretic gel according to claim 1, it is characterised in that described preservative is chloreresol, sodium sorbate, trichlorine In the tert-butyl alcohol, methyl hydroxybenzoate, ethylparaben, propylben, sulphite, cysteine any one or more Mixing.
9. antipyretic gel according to claim 1, it is characterised in that described wetting agent is ethanol, dimethyl sulfoxide, polyoxy second The mixing of any one or more in ene-type surfactant.
10. the antipyretic gel ballpoint device of a kind of use antipyretic gel, it is characterised in that including
Top is provided with the bottle of opening,
Ball assembly at bottle opening, the ball assembly includes ball base and is rollably partially submerged into the ball Ball in seat；And,
The lid of the ball assembly is threadedly coupled and covered with bottle；
Characterized in that, being provided with antipyretic gel described in claim 1 in the bottle.
CN201611089922.XA 2016-12-01 2016-12-01 Antipyretic gel and roll-on device thereof Pending CN106691669A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201611089922.XA CN106691669A (en) 2016-12-01 2016-12-01 Antipyretic gel and roll-on device thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201611089922.XA CN106691669A (en) 2016-12-01 2016-12-01 Antipyretic gel and roll-on device thereof

Publications (1)

Publication Number Publication Date
CN106691669A true CN106691669A (en) 2017-05-24

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107596355A (en) * 2017-09-27 2018-01-19 亳州市新健康科技有限公司 A kind of Medical pain easing, the exterior-applied gel subsided a swelling, brought down a fever and preparation method thereof

Citations (7)

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Publication number Priority date Publication date Assignee Title
CN1381254A (en) * 2002-04-29 2002-11-27 复旦大学 Medicine for treating fiver by nasal application and its preparing process
JP2013107911A (en) * 2013-03-13 2013-06-06 Lion Corp Colored patch
CN103191185A (en) * 2013-04-20 2013-07-10 江苏迪沃生物制品有限公司 Antipyretic gel
CN103598945A (en) * 2013-11-16 2014-02-26 王爽 Antipyretic gel
CN204092311U (en) * 2014-08-28 2015-01-14 罗银根 A kind of antipyretic gel device
CN104436206A (en) * 2014-12-17 2015-03-25 广西德之然生物科技有限公司 Plant colloidal material for preparing fever cooling patches and preparation method of plant colloidal material
CN105998185A (en) * 2016-06-29 2016-10-12 湖北博康医药科技有限公司 Antipyretic gel

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1381254A (en) * 2002-04-29 2002-11-27 复旦大学 Medicine for treating fiver by nasal application and its preparing process
JP2013107911A (en) * 2013-03-13 2013-06-06 Lion Corp Colored patch
CN103191185A (en) * 2013-04-20 2013-07-10 江苏迪沃生物制品有限公司 Antipyretic gel
CN103598945A (en) * 2013-11-16 2014-02-26 王爽 Antipyretic gel
CN204092311U (en) * 2014-08-28 2015-01-14 罗银根 A kind of antipyretic gel device
CN104436206A (en) * 2014-12-17 2015-03-25 广西德之然生物科技有限公司 Plant colloidal material for preparing fever cooling patches and preparation method of plant colloidal material
CN105998185A (en) * 2016-06-29 2016-10-12 湖北博康医药科技有限公司 Antipyretic gel

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107596355A (en) * 2017-09-27 2018-01-19 亳州市新健康科技有限公司 A kind of Medical pain easing, the exterior-applied gel subsided a swelling, brought down a fever and preparation method thereof

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