CN108992451A - A kind of emulsifiable paste and preparation method thereof with anti-inflammatory anti-itch antibiotic effect - Google Patents
A kind of emulsifiable paste and preparation method thereof with anti-inflammatory anti-itch antibiotic effect Download PDFInfo
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Abstract
The present invention relates to a kind of emulsifiable paste and preparation method thereof with anti-inflammatory anti-itch antibiotic effect, the emulsifiable paste with anti-inflammatory anti-itch antibiotic effect includes that each group of following weight percent is grouped as: menthol 1.0~5.0%, camphor 5.0~10.0%, gaultherolin 1.0~5.0%, borneol 0.5~1.0%, thymol 0.1~0.5%, beclomeasone propionate 0.01~0.05%, emulsifier Gelot 64 6.0~10.0%, octadecyl alcolol 3.0~6.0%, monoglyceride 4.0~7.0% and surplus purified water.The cream on skin irritation of formula of the present invention is small, lotion non-greasy, with be readily cleaned, active principle stability it is strong, holding time longer feature, the preparation method forms homogeneous phase body using emulsifier Gelot 64, octadecyl alcolol, monoglyceride and water, simplify technique, also have effective component more stable, there is the advantage of longer validity period.
Description
Technical field
The present invention relates to pharmaceutical technology field, especially a kind of emulsifiable paste and its preparation side with anti-inflammatory anti-itch antibiotic effect
Method.
Background technique
Skin is covered on human body surface, is the maximum organ of human body area, and for a long time, skin disease gives people daily life
Production brings great puzzlement.Cremor Mentholi Compositus is being commonly called as compound beclomethasone camphor emulsifiable paste, has anti-inflammatory, analgesia, antipruritic, anti-
The effects of bacterium, local anaesthesia, for insect dermatitis, papular urticaria, eczema, contact dermatitis, neurodermatitis, skin scabies
A variety of skin discomforts such as itch have preferable therapeutic effect.
In the prior art, the formula of Cremor Mentholi Compositus is numerous, and preparation process is more complicated, not due to oil phase component and water phase components
Can be compatible well, it must mutually be prepared oily respectively with water phase when preparation, and each self-heating promotes to chemically react in system,
It is last again that two-phase mixtures are integral.It is oily to be mutually prepared separately with water phase and limit the type of its formula, and need two to be arranged back-up
Not preparing oily phase can not reduce with water phase, production cost.In addition, the pH of usually Cremor Mentholi Compositus has skin certain 8.3 or so
Cusalgia sense, painting have apparent greasy feeling on the skin, not easy cleaning.Original cream can be broken by the pH that acid reagent reduces lotion
The stable state of body, and reduce the therapeutic effect of drug.The alkali substance reaction in stearic acid and component in electrodeless paste formulation
The stearate of generation, has the effect of stable prod.
Summary of the invention
Problem to be solved by this invention be existing Cremor Mentholi Compositus product using when have cusalgia sense to skin, preparation method is multiple
It is miscellaneous, the problem of high production cost;A kind of emulsifiable paste with anti-inflammatory anti-itch antibiotic effect, lotion small to skin irritation are provided
Non-greasy has the characteristics that be readily cleaned.
Applicant has found new technical problem during studying above-mentioned technical problem, Cremor Mentholi Compositus as OTC Class A medicine,
Validity period is 3 years, is the standing drug of many families, usual lotion can't be used up.Cremor Mentholi Compositus storage during, effectively at
The reasons such as the decomposition or reaction consumption that divide will cause active constituent content decline, so that curative effect declines or even fails, bring user
Puzzlement, or even cause conflict between doctors and patients.By constantly groping to find, Cremor Mentholi Compositus stores applicant under field conditions (factors), effectively at
Gaultherolin in point and it can all decline 10% after content 3 years of beclomeasone propionate, other compositions can be also varied.Cause
This, improves the stability of active principle in product, with guarantee preferable curative effect in long-time be the invention solves another
Key technical problem.Emulsifiable paste provided by the invention also has active principle stability strong, holding time longer feature.
The present invention also provides the preparation methods of the emulsifiable paste with anti-inflammatory anti-itch antibiotic effect, to solve existing product preparation
The problem of method is complicated, high production cost.Preparation method provided by the invention is easy to operate, preparation cost is lower.
In order to achieve the above objectives, technical scheme is as follows:
A kind of emulsifiable paste with anti-inflammatory anti-itch antibiotic effect, each group including following weight percent are grouped as:
Menthol 1.0~5.0%, camphor 5.0~10.0%, gaultherolin 1.0~5.0%, borneol 0.5~1.0%,
Thymol 0.1~0.5%, beclomeasone propionate 0.01~0.05%, emulsifier Gelot 64 6.0~10.0%, octadecyl alcolol
3.0~6.0%, monoglyceride 4.0~7.0% and surplus purified water;The pH=of the emulsifiable paste with anti-inflammatory anti-itch antibiotic effect
7.0±0.5。
Further, the emulsifiable paste with anti-inflammatory anti-itch antibiotic effect includes each group grouping of following weight percent
At:
Menthol 4.0~5.0%, camphor 8.0~10.0%, gaultherolin 4.0~5.0%, borneol 0.8~1.0%,
Thymol 0.4~0.5%, beclomeasone propionate 0.03~0.05%, emulsifier Gelot 64 7.0~9.0%, octadecyl alcolol
4.0~5.0%, monoglyceride 5.0~6.0% and surplus purified water.
Further, the emulsifiable paste with anti-inflammatory anti-itch antibiotic effect includes each group grouping of following weight percent
At:
Menthol 4.5%, camphor 9.0%, gaultherolin 4.5%, borneol 0.9%, thymol 0.45%, propionic acid times
Chlorine rice pine 0.05%, emulsifier Gelot 64 8.0%, octadecyl alcolol 4.5%, monoglyceride 5.5% and surplus purified water.
Further, the emulsifiable paste with anti-inflammatory anti-itch antibiotic effect further includes the ethyl alcohol for accounting for gross weight 0.1~0.5%.
The preparation method of the above-mentioned emulsifiable paste with anti-inflammatory anti-itch antibiotic effect is further disclosed in the present invention comprising following
Step:
1) each raw material is weighed by weight percentage;
2) purified water is added after mixing emulsifier Gelot 64, octadecyl alcolol, monoglyceride, is heated to the first temperature, stirs
Uniformly obtain mixture A;
3) mixture A is cooled into second temperature, menthol, camphor, borneol, thymol is added, continues to stir to get
Lotion B;
4) lotion B is cooled into third temperature, gaultherolin, beclomeasone propionate is added, stirring is cooled to room temperature, i.e.,
?.
Further, the first temperature described in step 2) is 70-90 DEG C.
Further, second temperature described in step 3) is 55-60 DEG C.
Further, third temperature described in step 4) is 48-52 DEG C.
Further, step 4) is that lotion B is cooled to third temperature, be added gaultherolin, beclomeasone propionate and
The ethyl alcohol of gross weight 0.1~0.5% is accounted for, stirring is cooled to room temperature to get the emulsifiable paste with anti-inflammatory anti-itch antibiotic effect.
The lotion that the present invention also protects the preparation method of the emulsifiable paste with anti-inflammatory anti-itch antibiotic effect to be prepared.
The utility model has the advantages that applicant's well-designed product formula with unique effects after scientific experiment solves well
It has determined product stable effective ingredients problem, after storing 3 years under field conditions (factors), gaultherolin and beclomeasone propionate
Changes of contents controls within 5%, preferable effect is still maintained in anti-inflammatory, antipruritic, antibiosis, so that product is in 3 terms
Interior therapeutic effect is stablized, and has preferably ensured the equity of patient.The cream on skin inflammation of formula of the present invention, itch and true
Bacterium infection has preferable therapeutic effect, can be used for insect dermatitis, papular urticaria, eczema, contact dermatitis, nerve skin
Inflammation, skin sufferings etc., it can also be used to treat pruritus ani.
Moreover phase 1 is constituted using emulsifier Gelot 64, octadecyl alcolol and monoglyceride in the present invention, it can after addition purified water
Uniform phase 2 is formed, water phase is mutually incompatible with oil to solve in the production of conventional electroless cream, it is necessary to be prepared separately, finally will
The technology puzzlement that water phase and oil mix.Due to the generation of phase 2, production technology is also simplified, stirring is added portionwise in remaining material
Uniformly, it avoids finally by the time-consuming and laborious of two-phase mixtures in traditional handicraft, because of oil phase and water phase body in traditional handicraft
Product is all larger, so that incompatible two-phase is formed uniform, stable phase under Action of Surfactant and need a large amount of time.
Further, mixture A cools to second temperature and menthol, borneol, thymol and camphor is just added, can be effective
Oil component is avoided to volatilize.Lotion B is cooled into third temperature, remaining material is added, reason is gaultherolin, propionic acid times
Higher than third temperature hydrolysis is easily occurring for chlorine rice pine, and temperature is too low to be unfavorable for lotion stirring.
In short, the cream on skin irritation of formula of the present invention is small, lotion non-greasy, there is easy cleaned spy
Point, the preparation method form homogeneous phase body using emulsifier Gelot 64, octadecyl alcolol, monoglyceride and water, simplify technique, also
It is more stable with effective component, there is the advantage of longer validity period, and this method is easy to operate, preparation cost is relatively low.
In order to more preferably illustrate effect of the invention, further illustrate that main component and its effect of the invention are as follows:
Menthol: external application has the function of antipruritic, anti-inflammatory, analgesic, while part being made to have cool feeling.Pain is clinically used for,
Inflammation and swelling.Also oral administration treatment headache, rhinitis, pharyngitis and laryngitis etc..
Artificial camphor: there is orifice opening;Qi stagnation removing;It wards off foul;Desinsection is antipruritic;The effects of swelling and pain relieving.Camphor is applied to skin
Skin has mild a stimulation and antisepsis, Central nervous system, to the circulatory system, and oral camphor (indicating edible) has wind dispelling
And slight phlegm-dispelling functions.
Gaultherolin: local external use's rubefacient.With local irritant effect, can promote local blood circulation, external application or
Part, which is embrocated, can produce the stimulate the reactions such as cutaneous vasodilation, the colour of skin be rubescent, and reflexive skin, the flesh for influencing corresponding site
Meat, nerve and joint play detumescence, anti-inflammatory and analgesic activity, also there is the benefits of antipruritic.For spraining, dampening, pain in the loins, courbature, mind
It is dysmenorrhoea, antipruritic.
Borneol: Chinese medicine takes the effect of its consciousness regaining, clearing away heat to and alleviating pain, erosion prevention and muscle growing more, modern pharmacological studies have shown that borneol
With a variety of medicinal efficacies, including easily through blood-brain barrier, promotion drug absorption, confrontation circulatory system ischemic and damage, centering
Pivot nervous system has bidirectional modulation and protection, antibacterial, anti-inflammatory, analgesia, antifertility, promotes the effects of wound healing.
Thymol: can promote tra cheo-oesophageal voice, be conducive to the secretion of tracheal mucus, easily play phlegm-dispelling functions, then added with
Bactericidal effect, therefore can be used for treating tracheitis, pertussis etc..
Beclomeasone propionate: it is potent external application glucocorticoids medicine, has the effects that anti-inflammatory, antiallergy and antipruritic, energy
Inhibit bronchus exudate, eliminate tunica mucosa bronchiorum swelling, releases bronchial spasm.
Emulsifier Gelot 64 is the mixture of stearine and PEG-75 stearate, is commercial product.
Octadecyl alcolol is the base stock of cream, lotion, has the function of thickening emulsion, is a kind of emulsion stabilizer.It is single sweet
Ester, that is, mono fatty acid glyceride, uses as surfactant.The addition of ethyl alcohol can help to the dissolution of beclomeasone propionate.
Specific embodiment
Technical solution of the present invention is further elaborated below with reference to embodiment.Particular technique or item are not specified in embodiment
Part person described technology or conditions or carries out according to the literature in the art according to product description.Agents useful for same or instrument
Production firm person is not specified in device, and being can be with conventional products that are commercially available.
Embodiment 1
The emulsifiable paste with anti-inflammatory anti-itch antibiotic effect is prepared, steps are as follows:
1) each raw material is weighed by 1 dosage of table;
2) 80 DEG C are being heated to after mixing emulsifier Gelot 64, octadecyl alcolol, monoglyceride, is being added under agitation
It is heated in 80 DEG C of purified water in advance, obtains mixture A;
3) mixture A is cooled to 58 DEG C, menthol, camphor, borneol, thymol is added, continues to stir to get lotion
B;
4) lotion B is cooled to 50 DEG C, is added remaining material, stirring be cooled to room temperature to get.
Prepared lotion is milky, and lotion quality is fine and smooth, pH=7.0 ± 0.5.
1 raw material dosage table (parts by weight) of table
Embodiment 2
The emulsifiable paste with anti-inflammatory anti-itch antibiotic effect is prepared, steps are as follows:
1) each raw material is weighed by 1 dosage of table;
2) 85 DEG C are being heated to after mixing emulsifier Gelot 64, octadecyl alcolol, monoglyceride, is being added under agitation
It is heated in 85 DEG C of purified water in advance, obtains mixture A;
3) mixture A is cooled to 55 DEG C, menthol, camphor, borneol, thymol is added, continues to stir to get lotion
B;
4) lotion B is cooled to 50 DEG C, is added remaining material, stirring be cooled to room temperature to get.
Prepared lotion is milky, and lotion quality is fine and smooth, pH=7.0 ± 0.5.
Embodiment 3
The emulsifiable paste with anti-inflammatory anti-itch antibiotic effect is prepared, steps are as follows:
1) each raw material is weighed by 1 dosage of table;
2) 75 DEG C are being heated to after mixing emulsifier Gelot 64, octadecyl alcolol, monoglyceride, is being added under agitation
It is heated in 75 DEG C of purified water in advance, obtains mixture A;
3) mixture A is cooled to 56 DEG C, menthol, camphor, borneol, thymol is added, continues to stir to get lotion
B;
4) lotion B is cooled to 50 DEG C, is added remaining material, stirring be cooled to room temperature to get.
Prepared lotion is milky, and lotion quality is fine and smooth, pH=7.0 ± 0.5.
Embodiment 4
The emulsifiable paste with anti-inflammatory anti-itch antibiotic effect is prepared, steps are as follows:
1) each raw material is weighed by 1 dosage of table;
2) 70 DEG C are being heated to after mixing emulsifier Gelot 64, octadecyl alcolol, monoglyceride, is being added under agitation
It is heated in 70 DEG C of purified water in advance, obtains mixture A;
3) mixture A is cooled to 55 DEG C, menthol, camphor, borneol, thymol is added, continues to stir to get lotion
B;
4) lotion B is cooled to 48 DEG C, is added remaining material, stirring be cooled to room temperature to get.
Prepared lotion is milky, and lotion quality is fine and smooth, pH=7.0 ± 0.5.
Embodiment 5
The emulsifiable paste with anti-inflammatory anti-itch antibiotic effect is prepared, steps are as follows:
1) each raw material is weighed by 1 dosage of table;
2) 90 DEG C are being heated to after mixing emulsifier Gelot 64, octadecyl alcolol, monoglyceride, is being added under agitation
It is heated in 90 DEG C of purified water in advance, obtains mixture A;
3) mixture A is cooled to 60 DEG C, menthol, camphor, borneol, thymol is added, continues to stir to get lotion
B;
4) lotion B is cooled to 52 DEG C, is added remaining material, stirring be cooled to room temperature to get.
Prepared lotion is milky, and lotion quality is fine and smooth, pH=7.0 ± 0.5.
Embodiment 6
The emulsifiable paste with anti-inflammatory anti-itch antibiotic effect is prepared, steps are as follows:
1) each raw material is weighed by 1 dosage of table;
2) 80 DEG C are being heated to after mixing emulsifier Gelot 64, octadecyl alcolol, monoglyceride, is being added under agitation
It is heated in 80 DEG C of purified water in advance, obtains mixture A;
3) mixture A is cooled to 58 DEG C, menthol, camphor, borneol, thymol is added, continues to stir to get lotion
B;
4) lotion B is cooled to 50 DEG C, is added remaining material, stirring be cooled to room temperature to get.
Prepared lotion is milky, and lotion quality is fine and smooth, pH=7.0 ± 0.5.
Embodiment 7
The emulsifiable paste with anti-inflammatory anti-itch antibiotic effect is prepared, steps are as follows:
1) each raw material is weighed by 1 dosage of table;
2) 85 DEG C are being heated to after mixing emulsifier Gelot 64, octadecyl alcolol, monoglyceride, is being added under agitation
It is heated in 85 DEG C of purified water in advance, obtains mixture A;
3) mixture A is cooled to 55 DEG C, menthol, camphor, borneol, thymol is added, continues to stir to get lotion
B;
4) lotion B is cooled to 50 DEG C, is added remaining material, stirring be cooled to room temperature to get.
Prepared lotion is milky, and lotion quality is fine and smooth, pH=7.0 ± 0.5.
Comparative example 1
The emulsifiable paste with anti-inflammatory anti-itch antibiotic effect is conventionally prepared, steps are as follows:
1) each raw material is weighed;Contain 0.35 gram of menthol, 0.56 gram of artificial camphor, gaultherolin by every 10 grams of Cremor Mentholi Compositus
0.3 gram, 0.05 gram of borneol, 0.025 gram of thymol, 0.001 gram of beclomeasone propionate.Auxiliary material: dimethyl sulfoxide, stearic acid,
Monoglyceride, albolene, octadecyl alcolol, glycerol, sodium hydroxide, potassium hydroxide all take 0.01 gram, and Purified Water q. s can dissolve hydrogen-oxygen
Change sodium, potassium hydroxide.
2) menthol, camphor, borneol, thymol, gaultherolin, beclomeasone propionate, dimethyl sulfoxide are mixed,
40 DEG C of dissolutions are heated to, mixture A is obtained;
3) 85 DEG C are being heated to after mixing emulsifier octadecyl alcolol, monoglyceride, albolene, stearic acid, is obtaining mixture
B;
4) 80 DEG C are heated to after mixing purified water, glycerol, sodium hydroxide, potassium hydroxide, obtains aqueous mixture C;
5) mixture A is added under agitation in mixture B, obtains oil mixture D;
6) oil mixture D is added under agitation in aqueous mixture C and is emulsified, mixing takes considerable time
It could complete emulsion process.Stirring be cooled to room temperature to get.
Prepared lotion is milky, and lotion quality is relatively partially hard, pH=8.3.
Compliance test result
The lotion of preparation is applied on arm and carries out sensory evaluation, the result is shown under by the sample size for randomly selecting 30 people
Table.
2 sense organ evaluating meter of table (people)
From table 2 it can be seen that formula of the present invention and the lotion that is prepared of method is small to skin irritation, lotion not
It is greasy, have the characteristics that be readily cleaned.
Content measuring is carried out to gaultherolin, the beclomeasone propionate in lotion, gaultherolin uses gas-chromatography
The detection of Internal standard correction methods method, beclomeasone propionate are detected using high performance liquid chromatography internal standard method, analyze the changes of contents of effective component
Situation, wherein content down ratio=(content after original amount-storage 3 years)/original amount * 100%, the results are shown in Table 3.
3 active constituent content of table changes table (%)
From table 3 it can be seen that gaultherolin and propionic acid times in the lotion that formula of the present invention and method are prepared
Content decline is within 5% after chlorine rice pine stores 3 years, and the lotion that comparative formulation obtains then is 10% or so, institute of the present invention
State formula and lotion that method is prepared in gaultherolin and beclomeasone propionate can exist steadily in the long term, even in water
In the case that poplar acid methyl esters and beclomeasone propionate have higher amount with respect to conventional electroless cream, still have higher product steady
It is qualitative, it ensure that the stability of therapeutic effect.
Clinical trial
Choose the pruitus that dermatology of institute of traditional Chinese medicine of the city accepts for medical treatment, inflammation patient 78 as research object, wherein male
Patient has 43, and female patient has 35, and the age is 26~59 years old, and average age is 39 years old, and the course of disease is 2 months~10 years.It adopts
This 78 patients are divided into control group (39) and treatment group (39) with random digits table, two groups of patients gender, the age,
Difference in terms of the general information such as the course of disease and the state of an illness is not significant (P > 0.05), does not have statistical significance, is comparable.It is right
According to group in the commercially available Cremor Mentholi Compositus of affected part external application (production of Shanghai Yan'an medicine company (Hubei) Co., Ltd), 2 times a day, continue 10 days.It controls
The lotion that treatment group is prepared using the embodiment of the present invention 1 smears affected part and continues 10 days 2 times a day.
Effect assessment standard: recovery from illness: the chafing of patient, itch situation completely disappear, coherence check skin as the result is shown
The pathogenic Staphylococci on skin surface, streptococcus are all negative.Effective: the chafing of patient, itch situation have clear improvement, phase
It closes inspection result and shows that the pathogenic Staphylococci of skin surface, streptococcus are all negative.It is invalid: the chafing of patient, itch
Situation is without improvement, or even aggravates, and the pathogenic Staphylococci of skin surface, streptococcus are all positive to coherence check as the result is shown.Always
Efficient=(recovery from illness number+effective number)/total number of persons * 100%.
It see the table below using the curative effect after 10 days.
4 therapeutic effect table of table
Group | Recovery from illness/people | Effective/people | In vain/people | Total effective rate % |
Control group | 17 | 12 | 10 | 74.36% |
Treatment group | 28 | 8 | 3 | 92.31% |
From table 4, it can be seen that lotion prepared by the present invention has preferable anti-inflammatory, antipruritic and antibacterial effect, product always has
Efficiency is higher by about 18 percentage points of commercially available Cremor Mentholi Compositus.
The preferred embodiment of the present invention has been described above in detail, still, during present invention is not limited to the embodiments described above
Detail within the scope of the technical concept of the present invention can be with various simple variants of the technical solution of the present invention are made, this
A little simple variants all belong to the scope of protection of the present invention.
It is further to note that specific technical features described in the above specific embodiments, in not lance
In the case where shield, it can be combined in any appropriate way.In order to avoid unnecessary repetition, the present invention to it is various can
No further explanation will be given for the combination of energy.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should also be regarded as the disclosure of the present invention.
Claims (10)
1. a kind of emulsifiable paste with anti-inflammatory anti-itch antibiotic effect, the emulsifiable paste with anti-inflammatory anti-itch antibiotic effect includes following heavy
The each group of amount percentage is grouped as:
Menthol 1.0~5.0%, camphor 5.0~10.0%, gaultherolin 1.0~5.0%, borneol 0.5~1.0%, Moschus
Careless phenol 0.1~0.5%, beclomeasone propionate 0.01~0.05%, emulsifier Gelot 64 6.0~10.0%, octadecyl alcolol 3.0
~6.0%, monoglyceride 4.0~7.0% and surplus purified water;
PH=7.0 ± 0.5 of the emulsifiable paste with anti-inflammatory anti-itch antibiotic effect.
2. the emulsifiable paste according to claim 1 with anti-inflammatory anti-itch antibiotic effect, it is characterised in that: described to stop with anti-inflammatory
The emulsifiable paste of antibiotic effect of itching includes that each group of following weight percent is grouped as:
Menthol 4.0~5.0%, camphor 8.0~10.0%, gaultherolin 4.0~5.0%, borneol 0.8~1.0%, Moschus
Careless phenol 0.4~0.5%, beclomeasone propionate 0.03~0.05%, emulsifier Gelot 64 7.0~9.0%, octadecyl alcolol 4.0~
5.0%, monoglyceride 5.0~6.0% and surplus purified water.
3. the emulsifiable paste according to claim 1 with anti-inflammatory anti-itch antibiotic effect, it is characterised in that: described to stop with anti-inflammatory
The emulsifiable paste of antibiotic effect of itching includes that each group of following weight percent is grouped as:
Menthol 4.5%, camphor 9.0%, gaultherolin 4.5%, borneol 0.9%, thymol 0.45%, propionic acid times chlorine rice
Pine 0.05%, emulsifier Gelot 64 8.0%, octadecyl alcolol 4.5%, monoglyceride 5.5% and surplus purified water.
4. the emulsifiable paste according to any one of claim 1-3 with anti-inflammatory anti-itch antibiotic effect, it is characterised in that: described
Emulsifiable paste with anti-inflammatory anti-itch antibiotic effect further includes the ethyl alcohol for accounting for gross weight 0.1~0.5%.
5. the preparation method of the emulsifiable paste described in claim 1 with anti-inflammatory anti-itch antibiotic effect, it is characterised in that: including following
Step:
1) weight percent according to claim 1 weighs each raw material;
2) purified water is added after mixing emulsifier Gelot 64, octadecyl alcolol, monoglyceride, is heated to the first temperature, stirs evenly
Obtain mixture A;
3) mixture A is cooled into second temperature, menthol, camphor, borneol, thymol is added, continues to stir to get lotion
B;
4) lotion B is cooled into third temperature, gaultherolin, beclomeasone propionate is added, stirring is cooled to room temperature to get institute
The emulsifiable paste with anti-inflammatory anti-itch antibiotic effect stated.
6. the preparation method of the emulsifiable paste according to claim 5 with anti-inflammatory anti-itch antibiotic effect, it is characterised in that: step
2) the first temperature described in is 70-90 DEG C.
7. the preparation method of the emulsifiable paste according to claim 5 with anti-inflammatory anti-itch antibiotic effect, it is characterised in that: step
3) second temperature described in is 55-60 DEG C.
8. the preparation method of the emulsifiable paste according to claim 5 with anti-inflammatory anti-itch antibiotic effect, it is characterised in that: step
4) third temperature described in is 48-52 DEG C.
9. the preparation method of the emulsifiable paste according to claim 5 with anti-inflammatory anti-itch antibiotic effect, it is characterised in that: step
4) for lotion B is cooled to third temperature, gaultherolin, beclomeasone propionate and the second for accounting for gross weight 0.1~0.5% is added
Alcohol, stirring are cooled to room temperature to get the emulsifiable paste with anti-inflammatory anti-itch antibiotic effect.
What 10. the preparation method of the described in any item emulsifiable pastes with anti-inflammatory anti-itch antibiotic effect of claim 5-9 was prepared
Emulsifiable paste.
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CN114886974A (en) * | 2022-05-30 | 2022-08-12 | 王兆晖 | Traditional Chinese medicine composition for diminishing inflammation and relieving pain |
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CN114159381A (en) * | 2021-12-30 | 2022-03-11 | 钟兆扬 | Scald ointment and preparation method and application thereof |
CN114886974A (en) * | 2022-05-30 | 2022-08-12 | 王兆晖 | Traditional Chinese medicine composition for diminishing inflammation and relieving pain |
CN115227796A (en) * | 2022-08-15 | 2022-10-25 | 王兆晖 | External traditional Chinese medicine formula for treating scapulohumeral periarthritis |
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