CN1086999A - External cream for treating common skin diseases and preparation method thereof - Google Patents
External cream for treating common skin diseases and preparation method thereof Download PDFInfo
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- CN1086999A CN1086999A CN 93103362 CN93103362A CN1086999A CN 1086999 A CN1086999 A CN 1086999A CN 93103362 CN93103362 CN 93103362 CN 93103362 A CN93103362 A CN 93103362A CN 1086999 A CN1086999 A CN 1086999A
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- oil
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- 208000017520 skin disease Diseases 0.000 title claims abstract description 11
- 239000006071 cream Substances 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 239000003814 drug Substances 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000000758 substrate Substances 0.000 claims abstract description 11
- 238000010438 heat treatment Methods 0.000 claims abstract description 10
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims abstract description 9
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims abstract description 9
- 229940121375 antifungal agent Drugs 0.000 claims abstract description 9
- 150000007980 azole derivatives Chemical class 0.000 claims abstract description 9
- 239000003429 antifungal agent Substances 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 8
- 230000001804 emulsifying effect Effects 0.000 claims abstract description 4
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims description 18
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims description 18
- 239000012071 phase Substances 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 12
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 9
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 239000005844 Thymol Substances 0.000 claims description 9
- 229960001047 methyl salicylate Drugs 0.000 claims description 9
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 9
- 229960000790 thymol Drugs 0.000 claims description 9
- 229960004495 beclometasone Drugs 0.000 claims description 8
- 229940025250 camphora Drugs 0.000 claims description 8
- 239000010238 camphora Substances 0.000 claims description 8
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 235000021355 Stearic acid Nutrition 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 4
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 4
- 239000008117 stearic acid Substances 0.000 claims description 4
- 239000008346 aqueous phase Substances 0.000 claims description 3
- 239000002075 main ingredient Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- IQXJCCZJOIKIAD-UHFFFAOYSA-N 1-(2-methoxyethoxy)hexadecane Chemical compound CCCCCCCCCCCCCCCCOCCOC IQXJCCZJOIKIAD-UHFFFAOYSA-N 0.000 claims description 2
- 229950009789 cetomacrogol 1000 Drugs 0.000 claims description 2
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 claims description 2
- 229940099259 vaseline Drugs 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 8
- 229940079593 drug Drugs 0.000 abstract description 4
- 230000000843 anti-fungal effect Effects 0.000 abstract description 2
- 241000233866 Fungi Species 0.000 abstract 1
- 229950000210 beclometasone dipropionate Drugs 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 description 5
- 241000238631 Hexapoda Species 0.000 description 5
- 201000009053 Neurodermatitis Diseases 0.000 description 5
- 206010046750 Urticaria papular Diseases 0.000 description 5
- 208000008664 papular urticaria Diseases 0.000 description 5
- AFNXATANNDIXLG-SFHVURJKSA-N 1-[(2r)-2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole Chemical compound C1=CC(Cl)=CC=C1CS[C@H](C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 AFNXATANNDIXLG-SFHVURJKSA-N 0.000 description 4
- MCCACAIVAXEFAL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 MCCACAIVAXEFAL-UHFFFAOYSA-N 0.000 description 4
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 description 4
- 206010048768 Dermatosis Diseases 0.000 description 4
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 4
- 208000002474 Tinea Diseases 0.000 description 4
- 241000130764 Tinea Species 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 229960003913 econazole Drugs 0.000 description 4
- 229960002509 miconazole Drugs 0.000 description 4
- 229960005040 miconazole nitrate Drugs 0.000 description 4
- 229960002607 sulconazole Drugs 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000002884 skin cream Substances 0.000 description 3
- 201000004647 tinea pedis Diseases 0.000 description 3
- MPIPASJGOJYODL-SFHVURJKSA-N (R)-isoconazole Chemical compound ClC1=CC(Cl)=CC=C1[C@@H](OCC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 MPIPASJGOJYODL-SFHVURJKSA-N 0.000 description 2
- QXHHHPZILQDDPS-UHFFFAOYSA-N 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound S1C=CC(COC(CN2C=NC=C2)C=2C(=CC(Cl)=CC=2)Cl)=C1Cl QXHHHPZILQDDPS-UHFFFAOYSA-N 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 2
- WHPAGCJNPTUGGD-UHFFFAOYSA-N Croconazole Chemical compound ClC1=CC=CC(COC=2C(=CC=CC=2)C(=C)N2C=NC=C2)=C1 WHPAGCJNPTUGGD-UHFFFAOYSA-N 0.000 description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 238000001949 anaesthesia Methods 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 150000003851 azoles Chemical class 0.000 description 2
- 229960005074 butoconazole Drugs 0.000 description 2
- SWLMUYACZKCSHZ-UHFFFAOYSA-N butoconazole Chemical compound C1=CC(Cl)=CC=C1CCC(SC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 SWLMUYACZKCSHZ-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229960004849 isoconazole Drugs 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 229960004214 tioconazole Drugs 0.000 description 2
- ZGOAEMCMBVUNMX-UHFFFAOYSA-N 1,1'-biphenyl;1h-pyrrole Chemical class C=1C=CNC=1.C1=CC=CC=C1C1=CC=CC=C1 ZGOAEMCMBVUNMX-UHFFFAOYSA-N 0.000 description 1
- OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 208000007163 Dermatomycoses Diseases 0.000 description 1
- 206010013700 Drug hypersensitivity Diseases 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 201000010618 Tinea cruris Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229960002206 bifonazole Drugs 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- -1 chlorine ketone Chemical class 0.000 description 1
- 229960002042 croconazole Drugs 0.000 description 1
- 201000003929 dermatomycosis Diseases 0.000 description 1
- 201000005311 drug allergy Diseases 0.000 description 1
- 229960003483 oxiconazole Drugs 0.000 description 1
- QRJJEGAJXVEBNE-MOHJPFBDSA-N oxiconazole Chemical compound ClC1=CC(Cl)=CC=C1CO\N=C(C=1C(=CC(Cl)=CC=1)Cl)\CN1C=NC=C1 QRJJEGAJXVEBNE-MOHJPFBDSA-N 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to an external cream for treating skin diseases of azole derivatives antifungal drugs, which comprises 5-25% of medicinal oil, 0.005-0.5% of beclomethasone dipropionate, azone, an azole derivative antifungal drug, a substrate and the like, wherein the proportions of the components are respectively 5-25%, 0.005-0.5%, 0.5-2%, 0.5-3% and 70-94%. The matrix may be of the oil-in-water type or the water-in-oil type. The preparation method comprises stirring the oil components, heating the oil phase in an oil phase pot, heating the water phase in a water phase pot, mixing, emulsifying, and cooling. The cream has more remarkable curative effect on various skin diseases caused by fungi, the total effective rate is more than 92%, and the cure rate is 62.7%.
Description
The present invention relates to a kind of dermatosis external-application cream of azole derivative antifungal agent.
The azole synthetic drug has been applied to the clinical treatment of dermatomycosis, for example econazole (isoconazole), sulconazole (sulconazole), miconazole (butaconazole) etc." miconazole " (Main Ingredients and Appearance is a miconazole nitrate) that Xian-Janssen Pharmaceutical Ltd. makes belongs to the broad-spectrum antifungal medicine, remarkable to treatment tinea effect in the department of dermatologry clinical practice, but sick to common skin as its unsatisfactory curative effects such as neurodermatitis, insect dermatitis and papular urticarias.
" WUJI GAO " that the applicant makes has antiinflammatory, analgesia, local anaesthesia and effect such as antibiotic, evident in efficacy to dermatosiss such as neurodermatitis, insect dermatitis and papular urticarias, its Main Ingredients and Appearance is Mentholum, artificial camphor, methyl salicylate, Borneolum Syntheticum, thymol and beclometasone etc.But this medicine is relatively poor to fungus-caused dermatosis such as various tinea curative effects such as hands, tinea pedis.
Purpose of the present invention aims to provide a kind ofly all has the external preparation for skin cream and the manufacture method thereof of significant curative effect to common skin diseases such as neurodermatitis, insect dermatitis, papular urticaria and various tinea etc.
The said external preparation for skin cream of the present invention comprises compositions such as the antifungal agent of medicine oil, beclometasone, azone, azole derivative and substrate, its proportioning is a medicine oil: 5%～25%, azole derivative antifungal agent: 0.5%～3%, beclometasone: 0.005%～0.05%, chlorine ketone: 0.5%～2%, substrate adds to 100%.
The composition of above-mentioned prescription Chinese medicine oil is Mentholum, thymol, Borneolum Syntheticum, Camphora and methyl salicylate etc., and its proportioning is a Mentholum: 1%～5%, and thymol, Borneolum Syntheticum, Camphora respectively are 0.1～6%, methyl salicylate: 1%～7%.
Substrate can be oil-in-water type or water-in-oil type, and its prescription is as follows.
1. oil-in-water type
Octadecanol: 1%～4%, stearic acid: 1%～6%, sodium hydroxide: 0.01%～0.5%, glycerol: 5%～15%, water adds to 100%.Wherein sodium hydroxide can be replaced by potassium hydroxide.
2. water-in-oil type
Octadecanol: 10%～30%, stearic acid: 2%～10%, vaseline: 10%～30%, class of department 80:1%～3%, cetomacrogol 1000: 1%～5%, water adds to 100%.
The antifungal agent of said azole derivative as " econazole " (isoconazole), " sulconazole " (sulconazole), " miconazole " (butaconazole), " tioconazole " (tioconazole), " croconazole " (cloconazole), " health azoles " (oxiconazole), " biphenyl azoles " (bifonazole), " miconazole nitrate " (miconazole nitrate), " Yi Kang azoles " (econazole) ... generally be to add single kind of derivant, consumption 0.5%～3%, preferably 1%～2%.
The content of azone is preferably 2%.
The said manufacture method of the present invention is
1. the medicine oil component is pressed proportioning stirring and dissolving in container;
With oil phase oil phase pot internal heating to 70～85 ℃;
With water water pot internal heating to 70～85 ℃;
4. the 2nd section oil phase thing is mixed with the 3rd section aqueous-phase material after stirring evenly again with fluid after the 1st section of dissolving and mix, and the emulsifying that stirs, be cooled to room temperature again and be finished product.
Wherein oil phase preferably is heated to more than 75 ℃ in the oil phase pot.
The using method of this external preparation for skin cream is to wipe the affected part every day 1～2 time, and general tinea is a course of treatment with 3～4 weeks, and serious symptom person can be with 2～3 courses of treatment.
The present invention on a kind of antifungal agent of azole derivative, add some have antiinflammatory, analgesia, local anaesthesia and antibacterial action in, western drug and efficient cutaneous permeable agent, all kinds of dermatosiss that the present invention is caused Mycophyta have significant more curative effect, its clinical trial shows, curative effect than other existing like products is stronger, neurodermatitis, insect dermatitis, papular urticaria, tinea pedis treatment total effective rate are reached more than 92% cure rate 62.7%.In addition, it does not produce drug allergy or other toxicities, and is safe in utilization.
Embodiment 1: with the proportioning of each composition be: medicine oil 5g, and miconazole nitrate 1g, beclometasone 0.005g, azone 1g, oil-in-water substrate adds to 100g.The used composition of its Chinese medicine oil is: Mentholum, thymol, methyl salicylate, Borneolum Syntheticum and Camphora respectively are 1g.Earlier the fluid composition is stirred in container by proportioning, in addition with oil phase oil phase pot internal heating to 70～85 ℃; Again with water more than water pot internal heating to 75 ℃, the oil phase thing mixed with aqueous-phase material mixes with fluid after the dissolving again after stirring evenly, and the emulsifying that stirs, to be cooledly to room temperature, be finished product.
Embodiment 2: the proportioning of each composition is elected as: medicine oil 15g, and econazole 2g, beclometasone 0.05g, azone 2g, oil-in-water substrate adds to 100g.The used composition of its Chinese medicine oil is: Mentholum 4g, thymol, Borneolum Syntheticum, Camphora respectively are 3g, methyl salicylate 2g.Its technology is with embodiment 1, wherein oil phase pot internal heating to 75 ℃.
Embodiment 3: the proportioning of each composition is elected as: medicine oil 25g, and miconazole 1.5g, beclometasone 0.025g, azone 0.5g, Water-In-Oil substrate adds to 100g.The used composition of its Chinese medicine oil is: Mentholum 3g, thymol, Borneolum Syntheticum, Camphora respectively are 5g, methyl salicylate 7g.Its technology is with embodiment 1, wherein oil phase pot internal heating to 80 ℃.
Below provide 4 routine clinical practice results.
Case 1: the patient * * *, tinea cruris, medical history 3 years is wiped this agent every day in the affected part for 1～2 time, and no longer recurrence is cured in medication 7 days.
Case 2: the patient * * *, insect dermatitis is wiped with this agent 2 times, recovery from illness in the 2nd day.
Case 3: the patient * * *, papular urticaria companion neurodermatitis is wiped the affected part every day 1～2 time, recovery from illness after 5 days.
Case 4: the patient * * *, tinea pedis medical history 10 years is cured after 15 days with this agent, continues medication again 10 days, does not see recurrence after the drug withdrawal in 3 months.
Claims (5)
1, a kind of treatment common skin diseases external-application cream, its Main Ingredients and Appearance has Mentholum, Camphora, methyl salicylate, Borneolum Syntheticum, thymol and beclometasone etc., it is characterized in that containing the antifungal agent and the substrate of azone, azole derivative; Mentholum, Camphora, methyl salicylate, Borneolum Syntheticum and thymol are formed medicine oil, and its proportioning is: medicine oil 5%～25%, and the antifungal agent 0.5%～3% of azole derivative, beclometasone 0.005%～0.05%, azone 0.5%～2%, substrate adds to 100%; The proportioning of medicine oil is a Mentholum 1%～5%, thymol, Borneolum Syntheticum, Camphora each 0.1%～6%, methyl salicylate 1%～7%.
2, external-application cream as claimed in claim 1, the proportioning that it is characterized in that azone is 2%.
3, external-application cream as claimed in claim 1 is characterized in that said substrate is oil-in-water type, and its prescription is octadecanol 1%～4%, stearic acid 1%～6%, and sodium hydroxide or potassium hydroxide 0.01%～0.5%, glycerol 5%～15%, water adds to 100%.
4, external-application cream as claimed in claim 1 is characterized in that said substrate is water-in-oil type, and its proportioning is an octadecanol 10%～30%, stearic acid 2%～10%, vaseline 10%～30%, class of department 80 is 1%～3%, cetomacrogol 1000 is 1%～5%, and water adds to 100%.
5, a kind of manufacture method for the treatment of the common skin diseases external-application cream is characterized in that
(1). the medicine oil component is stirred in container by proportioning;
(2). with oil phase oil phase pot internal heating to 70～85 ℃;
(3). with water water pot internal heating to 70～85 ℃;
(4). with the oil phase thing mix with aqueous-phase material stir evenly after again with dissolving after medicine oil mix and the emulsifying that stirs, to be cooledly get final product to room temperature.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93103362 CN1038387C (en) | 1993-03-20 | 1993-03-20 | External cream for treating common skin diseases and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93103362 CN1038387C (en) | 1993-03-20 | 1993-03-20 | External cream for treating common skin diseases and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1086999A true CN1086999A (en) | 1994-05-25 |
| CN1038387C CN1038387C (en) | 1998-05-20 |
Family
ID=4984613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93103362 Expired - Lifetime CN1038387C (en) | 1993-03-20 | 1993-03-20 | External cream for treating common skin diseases and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1038387C (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102233000A (en) * | 2010-04-28 | 2011-11-09 | 赵兴明 | Meizugao external ointment and preparation method thereof |
| CN103860567A (en) * | 2014-04-02 | 2014-06-18 | 符代兵 | External drug for treating skin diseases and preparation method thereof |
| CN105106234A (en) * | 2015-09-28 | 2015-12-02 | 兰晶 | Anti-allergy and anti-inflammatory external preparation special for treatment of allergic dermatitis |
| CN108992451A (en) * | 2018-07-09 | 2018-12-14 | 漳州无极药业有限公司 | A kind of emulsifiable paste and preparation method thereof with anti-inflammatory anti-itch antibiotic effect |
| CN114159381A (en) * | 2021-12-30 | 2022-03-11 | 钟兆扬 | Scald ointment and preparation method and application thereof |
-
1993
- 1993-03-20 CN CN 93103362 patent/CN1038387C/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102233000A (en) * | 2010-04-28 | 2011-11-09 | 赵兴明 | Meizugao external ointment and preparation method thereof |
| CN103860567A (en) * | 2014-04-02 | 2014-06-18 | 符代兵 | External drug for treating skin diseases and preparation method thereof |
| CN103860567B (en) * | 2014-04-02 | 2015-09-30 | 符代兵 | One treats dermopathic external used medicine and preparation method thereof |
| CN105106234A (en) * | 2015-09-28 | 2015-12-02 | 兰晶 | Anti-allergy and anti-inflammatory external preparation special for treatment of allergic dermatitis |
| CN108992451A (en) * | 2018-07-09 | 2018-12-14 | 漳州无极药业有限公司 | A kind of emulsifiable paste and preparation method thereof with anti-inflammatory anti-itch antibiotic effect |
| CN108992451B (en) * | 2018-07-09 | 2021-03-09 | 漳州无极药业有限公司 | Cream with anti-inflammatory, itching-relieving and antibacterial effects and preparation method thereof |
| CN114159381A (en) * | 2021-12-30 | 2022-03-11 | 钟兆扬 | Scald ointment and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1038387C (en) | 1998-05-20 |
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