CN109692183A - A kind of sterilizing agent for external use and preparation method thereof for eliminating foot smell - Google Patents

A kind of sterilizing agent for external use and preparation method thereof for eliminating foot smell Download PDF

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Publication number
CN109692183A
CN109692183A CN201910187090.2A CN201910187090A CN109692183A CN 109692183 A CN109692183 A CN 109692183A CN 201910187090 A CN201910187090 A CN 201910187090A CN 109692183 A CN109692183 A CN 109692183A
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parts
solution
iodine
hydrogen peroxide
external use
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CN201910187090.2A
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Chinese (zh)
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欧先富
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Individual
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/40Peroxides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/18Iodine; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics

Abstract

The sterilizing agent for external use and preparation method thereof that the present invention relates to a kind of for eliminating foot smell, the thimerosal include the raw material proportioning composition of following parts by weight: 40~50 parts of polyvinylpyrrolidonesolution solution, 10~15 parts of hydrogen peroxide, 5~10 parts of liquor kalii iodide, 1~5 part of iodine and purified water are mended to 100 parts.The sterilizing agent for external use prepared using the method for the invention selects hydrogen peroxide, iodine and the potassium iodide raw material with sterilizing effect;It also selects simultaneously and is not involved in human metabolism, and there is excellent biocompatibility, do not form the polyvinylpyrrolidone of any stimulation to skin as auxiliary material, its component is simple, and proportion rationally, has antibiotic and sterilizing ability strong, easy to use, at low cost, eliminating foot smell effect is good, it is quick, while eliminating foot smell, the stimulation harmful effect to human body can be also reduced, has very strong disinfection to skin, it is non-stimulated to skin zero damage.

Description

A kind of sterilizing agent for external use and preparation method thereof for eliminating foot smell
Technical field
The invention belongs to external sterilizing technical fields, and in particular to a kind of sterilizing agent for external use and its system for eliminating foot smell Preparation Method.
Background technique
Foot odour is to be easy to perspire since arch of the foot sweat gland, in sweat exceptionally except moisture content, salt, also contains lactic acid and urea. Under the conditions of hidrosis, bacterium mass propagation on foot simultaneously decomposes keratoprotein, along with urea, the lactic acid in sweat, thus A kind of stink can be issued.If shoes are airtight, the more long-pending atmosphere draught-free, stink will be the denseer, and foul smell is extremely strong.Usual people Tinea pedis and foot odour are lumped together, they are distinguishing in fact.The people of tinea pedis generally can have perspiration, foot odour, and foot, which is itched, waits diseases Shape will appear scaling, redness, bubble, breach, the symptoms such as fester between serious patient's toe seam.And the root of foot odour but foot Skin perspiration is more, there is foul smell, and serious tinea pedis can be developed into for a long time by going down.The main reason for causing foot odour is that one kind is tinea alba The fungi of bacterium, it generates unpleasant stench after decomposing skin metabolism object.
Eliminating foot smell is wanted, people will recognize that the popularity such as Da Kening, Pevisone, Lamisil are higher naturally, have certain effect Antifungal products, be all that gloomy product is raised in Xi'an up to a gram peace Pevisone, both use imidazoles broad-spectrum antifungal medicine Object is made as main component, and only the latter is added to antipruritic, anti-allergic effects glucocorticoid-Triamcinolone acetonides;And The main component of Lamisil is terbinafine HCl and a kind of drug with killing fungi effect.To antimycotic, in addition to medicine It is civil also to spread a lot of folk prescriptions other than object, it is stated that garlic, potassium permanganate, vinegar, radish, Chinese prickly ash, alum etc. can control foot It is smelly.But whether which kind of method, it requires that people are patient, can persist, because once losing vigilance, fungi It can just breed quickly again, the extended treatment time.Foot odour patient be at for a long time it is such a treatment, mitigate, be discontinued, Among recurrence, the vicious circle of re-treatment.Mainly caused by Pathogen Infection due to foot odour, other skins are rotten Rotten, bubble, keratinization, feel to itch pain phenomena such as be all due to Pathogen Infection after subsidiary symptom.Therefore, it is necessary to a kind of uses It is convenient, it is at low cost, additionally it is possible to which that the thimerosal for rapidly and efficiently killing fungi is the key factor for solving foot odour.
Summary of the invention
The technical problem to be solved by the present invention is to simple for a kind of formula the problems of in the prior art, is provided It is single, at low cost, it is easy to use, fungi present on skin is being killed at the same time it can also nursing skin, and there is safe and reliable, energy Enough foot sterilizing agent for external use for quickly killing fungi, specifically a kind of sterilizing agent for external use and its preparation for eliminating foot smell Method.
In order to solve the above technical problems, the technical scheme adopted by the invention is that: a kind of external application for eliminating foot smell disappears Venom, the thimerosal include the raw material proportioning composition of following parts by weight: 40~50 parts of polyvinylpyrrolidonesolution solution, peroxide Change 10~15 parts of hydrogen, 5~10 parts of liquor kalii iodide, 1~5 part of iodine and purified water to mend to 100 parts.
Further, the sterilizing agent for external use of the present invention for eliminating foot smell, wherein the thimerosal include with The raw material proportioning of lower parts by weight forms: 43~46 parts of polyvinylpyrrolidonesolution solution, 10~12 parts of hydrogen peroxide, liquor kalii iodide 6~8 parts, 2~3 parts of iodine and purified water are mended to 100 parts.
Further, the sterilizing agent for external use of the present invention for eliminating foot smell, wherein the polyvinylpyrrolidone Solution is the medicinal alcohol solution containing 30~40% polyvinylpyrrolidones, and the hydrogen peroxide is medical hydrogen peroxide, the iodine Change potassium solution is the aqueous solution containing 2~5% potassium iodide.
The invention also discloses the method for the above-mentioned sterilizing agent for external use for eliminating foot smell, the preparation method includes as follows Step: polyvinylpyrrolidone, hydrogen peroxide, liquor kalii iodide and iodine are weighed respectively according to the above parts by weight of raw materials, together Shi Peibei purified water grinds the iodine for fine powder, in the container that then resulting fine powder is added, then Polyvinylpyrrolidonesolution solution is added into container, dilutes at normal temperature, after mixing evenly, the iodine powder is diluted to The solution that concentration is 15~20%, obtains iodine solution;Simultaneously by hydrogen peroxide purified water dissolved dilution, hydrogen peroxide is controlled Concentration is 2.5~3.5% to get hydrogenperoxide steam generator;Then by gained iodine solution and hydrogenperoxide steam generator and remaining poly- Vinylpyrrolidone solution is added into container, and purified water is added and mends to 100 parts, and emulsifying 2~6 minutes to get institute Sterilizing agent for external use is stated, and is bottled according to a conventional method.
Further, the preparation method of the sterilizing agent for external use of the present invention for eliminating foot smell, wherein the preparation Method includes the following steps: to weigh 45 parts of polyvinylpyrrolidone, 10 parts of hydrogen peroxide, iodine respectively according to the above parts by weight of raw materials Change 7 parts of potassium solution, 3 parts of iodine, while being equipped with purifying distilled water, the iodine is ground as fine powder, then will Gained fine powder is added to the container, and polyvinylpyrrolidonesolution solution is then added into container, dilutes at normal temperature, stirs evenly Afterwards, the iodine powder is diluted to the solution that concentration is 18%, obtains iodine solution;Simultaneously by the hydrogen peroxide purified water Dissolved dilution controls concentration of hydrogen peroxide 3% to get hydrogenperoxide steam generator;Then gained iodine solution and hydrogen peroxide is molten Liquid and remaining polyvinylpyrrolidonesolution solution are added into container, and purified water is added and mends to 100 parts, and emulsifying 3 ~4 minutes to get the sterilizing agent for external use, and according to a conventional method bottle.
Using the sterilizing agent for external use and preparation method thereof of the present invention for eliminating foot smell, compared with prior art, The beneficial effect is that: select hydrogen peroxide, iodine and the potassium iodide raw material with sterilizing effect;It also selects not simultaneously Human metabolism is participated in, and there is excellent biocompatibility, does not form the polyvinyl pyrrole of any stimulation to skin For alkanone as auxiliary material, component is simple, and proportion rationally, has antibiotic and sterilizing ability strong, easy to use, at low cost, eliminating foot smell Effect is good, quick, while eliminating foot smell, can also reduce the stimulation harmful effect to human body, have very strong disappear to skin Toxic action, it is non-stimulated to skin zero damage.
Specific embodiment
In order to more fully explain implementation of the invention, the present invention is further illustrated below in conjunction with specific embodiment.Institute It gives an actual example and is served only for explaining the present invention, rather than limit the scope of the invention, raw materials used in following embodiments is commercially available obtain ?.
Embodiment 1:
A kind of external application spray coating liquor for eliminating foot smell, the spray coating liquor include the raw material proportioning composition of following parts by weight: being contained 10 parts of 40 parts of medicinal alcohol solution, the hydrogen peroxide of 30% polyvinylpyrrolidone, 5 parts of aqueous solution, simple substance containing 2% potassium iodide 1 part of iodine and purified water are mended to 100 parts.
The sterilizing agent for external use the preparation method is as follows: weighing polyvinylpyrrolidine respectively according to the above parts by weight of raw materials Ketone, hydrogen peroxide, liquor kalii iodide and iodine, while being equipped with purified water grind the iodine for fine powder, so In the container that resulting fine powder is added afterwards, polyvinylpyrrolidonesolution solution is then added into container, dilutes at normal temperature, After mixing evenly, the iodine powder is diluted to the solution that concentration is 15%, obtains iodine solution;Simultaneously by the hydrogen peroxide With purified water dissolved dilution, concentration of hydrogen peroxide is controlled 2.5% to get hydrogenperoxide steam generator;Then by gained iodine solution and mistake Hydrogen peroxide solution and remaining polyvinylpyrrolidonesolution solution are added into container, and purified water is added and mends to 100 parts, and Emulsifying 2~4 minutes to get the sterilizing agent for external use, and according to a conventional method bottle.
Embodiment 2:
A kind of sterilizing agent for external use for eliminating foot smell, the thimerosal include the raw material proportioning composition of following parts by weight: being contained 12 parts of 43 parts of medicinal alcohol solution, the hydrogen peroxide of 32% polyvinylpyrrolidone, 6 parts of the aqueous solution containing 2.5% potassium iodide, list 2 parts of matter iodine and purified water are mended to 100 parts.
The sterilizing agent for external use the preparation method is as follows: weighing polyvinylpyrrolidine respectively according to the above parts by weight of raw materials Ketone, hydrogen peroxide, liquor kalii iodide and iodine, while being equipped with purified water grind the iodine for fine powder, so In the container that resulting fine powder is added afterwards, polyvinylpyrrolidonesolution solution is then added into container, dilutes at normal temperature, After mixing evenly, the iodine powder is diluted to the solution that concentration is 17%, obtains iodine solution;Simultaneously by the hydrogen peroxide With purified water dissolved dilution, concentration of hydrogen peroxide is controlled 2.8% to get hydrogenperoxide steam generator;Then by gained iodine solution and mistake Hydrogen peroxide solution and remaining polyvinylpyrrolidonesolution solution are added into container, and purified water is added and mends to 100 parts, and Emulsifying 3~5 minutes to get the sterilizing agent for external use, and according to a conventional method bottle.
Embodiment 3:
A kind of sterilizing agent for external use for eliminating foot smell, the thimerosal include the raw material proportioning composition of following parts by weight: being contained 10 parts of 45 parts of medicinal alcohol solution, the hydrogen peroxide of 35% polyvinylpyrrolidone, 7 parts of the aqueous solution containing 3.5% potassium iodide, list 3 parts of matter iodine and purified water are mended to 100 parts.
The sterilizing agent for external use the preparation method is as follows: weighing polyvinylpyrrolidine respectively according to the above parts by weight of raw materials Ketone, hydrogen peroxide, liquor kalii iodide, iodine, while it being equipped with purifying distilled water, the iodine is ground as fine powder Then gained fine powder is added to the container by end, polyvinylpyrrolidonesolution solution is then added into container, dilute at normal temperature It releases, after mixing evenly, the iodine powder is diluted to the solution that concentration is 18%, obtains iodine solution;Simultaneously by the peroxidating Hydrogen purified water dissolved dilution controls concentration of hydrogen peroxide 3% to get hydrogenperoxide steam generator;Then by gained iodine solution and Hydrogenperoxide steam generator and remaining polyvinylpyrrolidonesolution solution are added into container, and purified water is added and mends to 100 parts, And emulsifying 3~4 minutes to get the sterilizing agent for external use, and according to a conventional method bottle.
Embodiment 4:
A kind of external application spray coating liquor for eliminating foot smell, the spray coating liquor include the raw material proportioning composition of following parts by weight: poly- Vinylpyrrolidone solution is 12 parts of 46 parts of medicinal alcohol solution, hydrogen peroxide containing 38% polyvinylpyrrolidone, contains 4% iodine 3 parts of 8 parts of aqueous solution, the iodine and purified water for changing potassium are mended to 100 parts.
The sterilizing agent for external use the preparation method is as follows: weighing polyvinylpyrrolidine respectively according to the above parts by weight of raw materials Ketone, hydrogen peroxide, liquor kalii iodide and iodine, while being equipped with purified water grind the iodine for fine powder, so In the container that resulting fine powder is added afterwards, polyvinylpyrrolidonesolution solution is then added into container, dilutes at normal temperature, After mixing evenly, the iodine powder is diluted to the solution that concentration is 18%, obtains iodine solution;Simultaneously by the hydrogen peroxide With purified water dissolved dilution, concentration of hydrogen peroxide is controlled 3.2% to get hydrogenperoxide steam generator;Then by gained iodine solution and mistake Hydrogen peroxide solution and remaining polyvinylpyrrolidonesolution solution are added into container, and purified water is added and mends to 100 parts, and Emulsifying 3~5 minutes to get the sterilizing agent for external use, and according to a conventional method bottle.
Embodiment 5:
A kind of external application spray coating liquor for eliminating foot smell, the spray coating liquor include the raw material proportioning composition of following parts by weight: poly- Vinylpyrrolidone solution is 15 parts of 50 parts of medicinal alcohol solution, hydrogen peroxide containing 40% polyvinylpyrrolidone, contains 5% iodine 5 parts of 10 parts of aqueous solution, the iodine and purified water for changing potassium are mended to 100 parts.
The sterilizing agent for external use the preparation method is as follows: weighing polyvinylpyrrolidine respectively according to the above parts by weight of raw materials Ketone, hydrogen peroxide, liquor kalii iodide and iodine, while being equipped with purified water grind the iodine for fine powder, so In the container that resulting fine powder is added afterwards, polyvinylpyrrolidonesolution solution is then added into container, dilutes at normal temperature, After mixing evenly, the iodine powder is diluted to the solution that concentration is 20%, obtains iodine solution;Simultaneously by the hydrogen peroxide With purified water dissolved dilution, concentration of hydrogen peroxide is controlled 3.5% to get hydrogenperoxide steam generator;Then by gained iodine solution and mistake Hydrogen peroxide solution and remaining polyvinylpyrrolidonesolution solution are added into container, and purified water is added and mends to 100 parts, and Emulsifying 5~6 minutes to get the sterilizing agent for external use, and according to a conventional method bottle.
By using sterilizing agent for external use of the present invention, it can achieve and kill pathogen, anti-inflammatory analgetic, antipruritic effect Fruit, at the same it is without any side effects, it is easy to use, affected part is coated on after foot bath, mild person 2-3 times is to take effect, 7-10 days Just there is no foot odour problem, take effect for severe one 4-6 times, can achieve radical cure in two to three weeks.In order to show external application of the present invention Spray coating liquor dispels effect, is given below and is explained using sterilizing agent for external use of the present invention for eliminating foot smell case:
Europe, male, 52 years old, foot odour have five wheat harvesting periods, once used a variety of drug therapies, but ineffective, used present invention reality The spray coating liquor of example 3 is applied, after applying 5 times, does not find foot odour problem.
Field so-and-so, female, 35 years old, foot odour had two wheat harvesting periods, once used other medicines treat, but be easy occur foot repeatedly Smelly problem.Afterwards using spray coating liquor described in the embodiment of the present invention 2, coating had positive effect after 3 days, without discovery foot odour after 10 days Problem.
Mr. Wang, male, 28 years old, foot odour had half a year, and other medicines was once used to treat, but was easy to occur foot odour repeatedly and ask Topic.Afterwards using spray coating liquor described in the embodiment of the present invention 4, coating had positive effect after 5 days, asked after 15 days without discovery foot odour Topic.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair The improvement for the various unsubstantialities that bright method concept and technical solution carry out, or it is not improved by design and technology of the invention Scheme directly applies to other occasions, within the scope of the present invention.

Claims (5)

1. a kind of sterilizing agent for external use for eliminating foot smell, it is characterised in that: the thimerosal includes the original of following parts by weight Material proportion composition: 40~50 parts of polyvinylpyrrolidonesolution solution, 10~15 parts of hydrogen peroxide, 5~10 parts of liquor kalii iodide, simple substance 1~5 part of iodine and purified water are mended to 100 parts.
2. the sterilizing agent for external use according to claim 1 for eliminating foot smell, it is characterised in that: the thimerosal includes The raw material proportioning of following parts by weight forms: 43~46 parts of polyvinylpyrrolidonesolution solution, 10~12 parts of hydrogen peroxide, potassium iodide are molten 6~8 parts of liquid, 2~3 parts of iodine and purified water are mended to 100 parts.
3. the sterilizing agent for external use according to claim 1 or 2 for eliminating foot smell, it is characterised in that: the polyethylene pyrrole Pyrrolidone solution is the medicinal alcohol solution containing 30~40% polyvinylpyrrolidones, and the hydrogen peroxide is medical hydrogen peroxide, The liquor kalii iodide is the aqueous solution containing 2~5% potassium iodide.
4. a kind of method for preparing the sterilizing agent for external use as claimed in claim 1 or 2 for eliminating foot smell, which is characterized in that The preparation method includes the following steps: to weigh polyvinylpyrrolidone, hydrogen peroxide, iodine respectively according to the above parts by weight of raw materials Change potassium solution and iodine, while being equipped with purified water, the iodine is ground as fine powder, then by resulting fine powder In the container that end is added, polyvinylpyrrolidonesolution solution is then added into container, dilutes at normal temperature, it after mixing evenly, will The iodine powder is diluted to the solution that concentration is 15~20%, obtains iodine solution;The hydrogen peroxide is purified simultaneously water-soluble Solution dilution controls concentration of hydrogen peroxide 2.5~3.5% to get hydrogenperoxide steam generator;Then by gained iodine solution and peroxidating Hydrogen solution and remaining polyvinylpyrrolidonesolution solution are added into container, and purified water is added and mends to 100 parts, and homogeneous 2~6 minutes are emulsified to get the sterilizing agent for external use, and bottle according to a conventional method.
5. the preparation method of the sterilizing agent for external use according to claim 4 for eliminating foot smell, which is characterized in that the system Preparation Method include the following steps: to weigh respectively according to the above parts by weight of raw materials 45 parts of polyvinylpyrrolidone, 10 parts of hydrogen peroxide, 7 parts of liquor kalii iodide, 3 parts of iodine, while being equipped with purifying distilled water grind the iodine for fine powder, then Gained fine powder is added to the container, polyvinylpyrrolidonesolution solution is then added into container, dilutes at normal temperature, stirring is equal After even, the iodine powder is diluted to the solution that concentration is 18%, obtains iodine solution;The hydrogen peroxide is purified simultaneously Water dissolved dilution controls concentration of hydrogen peroxide 3% to get hydrogenperoxide steam generator;Then by gained iodine solution and hydrogen peroxide Solution and remaining polyvinylpyrrolidonesolution solution are added into container, and purified water is added and mends to 100 parts, and homogenized milk Change 3~4 minutes to get the sterilizing agent for external use, and bottle according to a conventional method.
CN201910187090.2A 2019-03-13 2019-03-13 A kind of sterilizing agent for external use and preparation method thereof for eliminating foot smell Pending CN109692183A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1088438A (en) * 1993-01-14 1994-06-29 吴霜 Spirit (Kexianxing) is put in the dermopathic pharmaceutical preparation one of a kind of control on the skin
US20040209954A1 (en) * 2003-04-18 2004-10-21 Lukacsko Alison B. Compositions and methods for treating body malodor and fungal overgrowth in mammals
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CN106821974A (en) * 2017-03-29 2017-06-13 佛山市南海东方澳龙制药有限公司 The preparation method of Betagen Solution and the Betagen Solution prepared by the method

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Publication number Priority date Publication date Assignee Title
CN1088438A (en) * 1993-01-14 1994-06-29 吴霜 Spirit (Kexianxing) is put in the dermopathic pharmaceutical preparation one of a kind of control on the skin
US20040209954A1 (en) * 2003-04-18 2004-10-21 Lukacsko Alison B. Compositions and methods for treating body malodor and fungal overgrowth in mammals
WO2005115336A2 (en) * 2004-05-15 2005-12-08 Collegium Pharmaceutical, Inc. Sprayable formulations for the treatment of acute inflammatory skin conditions
CN105410021A (en) * 2015-12-21 2016-03-23 青岛拓联信息技术有限公司 Non-irritant disinfectant fluid for daily use
CN106821974A (en) * 2017-03-29 2017-06-13 佛山市南海东方澳龙制药有限公司 The preparation method of Betagen Solution and the Betagen Solution prepared by the method

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Application publication date: 20190430