CN108815140A - A kind of retreat stickers of long-acting slow cooling - Google Patents
A kind of retreat stickers of long-acting slow cooling Download PDFInfo
- Publication number
- CN108815140A CN108815140A CN201810853347.9A CN201810853347A CN108815140A CN 108815140 A CN108815140 A CN 108815140A CN 201810853347 A CN201810853347 A CN 201810853347A CN 108815140 A CN108815140 A CN 108815140A
- Authority
- CN
- China
- Prior art keywords
- parts
- pharmaceutical carrier
- long
- slow cooling
- retreat stickers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to biomedicine technical fields, and in particular to a kind of retreat stickers of long-acting slow cooling；The type retreat stickers include the substrate prepared by non-woven fabrics from the bottom to top, and the moisture absorption pharmaceutical carrier of substrate center coating, the semi-transparency type film of pharmaceutical carrier surface covering and hygroscopic carrier periphery are constituted in the pressure sensitive adhesive that substrate surface is coated with；Region tow sides on substrate in addition to dilute moisture absorption pharmaceutical carrier are coated with waterproof membrane, and pressure sensitive adhesive is coated on waterproof membrane.The component of moisture absorption pharmaceutical carrier includes：Moisturizing sustained release agent, borneol, mint extract, glycerol, ethyl alcohol, bacteriostatic preservative and aromatic.Contain bacteriostatic peptide and methyl p-hydroxybenzoate in bacteriostatic preservative；Waterproof membrane is polyethylene film or polypropylene screen.The type retreat stickers have the good effect of bringing down a fever that radiates, and heat dissipation effect is stable and the duration is long, will not cause to stimulate to skin or damage.
Description
Technical field
The present invention relates to biomedicine technical fields, and in particular to a kind of retreat stickers of long-acting slow cooling.
Background technique
Fever is also known as generated heat, and is a kind of medical pathologies sign.Mainly since the effect of pyrogen makes body temperature set point
Modulability body temperature caused by moving up increases.Everyone normal body temperature is slightly different, and by time, season, environment, physiology
The influence of many factors such as period.Therefore, it is determined that whether having a fever, need to compare with the body temperature under oneself usually similarity condition；One
As in the case of, body temperature be more than 37 DEG C can determine whether for fever.The reason of causing fever very much, most commonly various bacterium infections,
Virus infection, mycoplasma infection etc., followed by connective tissue disease, malignant tumour etc..Fever is favorably also harmful to human body.Adstante febre
Immune function of human body is remarkably reinforced, this is conducive to remove pathogen and promotes the recovery from illness of disease.And fever is also rehabilitation
One mark, therefore, when body temperature is less high,.
The poor crowd of the resistances such as infant and old man is easier to have a fever when by chill, virus infection,
But for not serious slight fever, it is not necessary to it is treated immediately using chemicals such as antibiotic, in order to avoid abuse of antibiotics
So that human body produces drug resistance, can be brought down a fever using some physical methods, and immunity is restored in conjunction with dietotherapy, also
Fever bring sense of discomfort can be reduced by drinking water more.
Conventional physics method of bringing down a fever includes wet towel wiping and cold compress etc., pharmacy also have retreat stickers it is such dedicated for
It brings down a fever the medical product of cooling.Retreat stickers are called defervescence plaster used, and retreat stickers are by moisture vaporization in gel by intracorporal excessive heat
Amount volatilize away, so that reaching the hypothermic effect of drop allows children's health safety cooling, while not destroying that children are intracorporal to be immunized
Function system reaction.It belongs to Physical temperature-lowering articles, and because it is brought down a fever fastly, good cooling effect is safe and non-toxic secondary and be widely used
It has a fever in fever in children.
But because most retreat stickers mainly pass through medicinal alcohol and cool down as evaporative heat loss substance, refrigerant guarantor
Strong single effect, the cooling effect at retreat stickers initial stage is more quick, but the duration that cools down is not grown, and the use of the time is generally 6-
8 hours, the alcohol in retreat stickers and a small amount of moisture evaporated later, and dry retreat stickers are difficult to continue to play the effect of bringing down a fever.
But many parents wish that 12-24 hours or even 24 hours or more can be continued in the effect of retreat stickers, it in this way can be to avoid frequency
Numerous replacement prevents from replacing in the baby sleep time and causes to frighten to infant.
In addition, the medicinal alcohol excessive concentration in conventional retreat stickers, is in direct contact on the tender skin of infant, in number
Stronger stimulation can be generated to skin in the use process of hour, the skin of child be caused to be damaged.
Summary of the invention
Aiming at the problems existing in the prior art, the present invention provides a kind of retreat stickers of long-acting slow cooling, which is moved back
Burning patch has the good effect of bringing down a fever that radiates, and heat dissipation effect is stable and the duration is long, will not cause to stimulate to skin or damage.
In order to achieve the above object, the present invention is achieved through the following technical solutions：
A kind of retreat stickers of long-acting slow cooling, retreat stickers include the substrate prepared by non-woven fabrics from the bottom to top, in substrate
The moisture absorption pharmaceutical carrier of coating is entreated, the semi-transparency type film of pharmaceutical carrier surface covering and hygroscopic carrier periphery are in substrate surface
The pressure sensitive adhesive of coating is constituted；Region tow sides on substrate in addition to dilute moisture absorption pharmaceutical carrier are coated with waterproof membrane, pressure-sensitive
Glue is coated on waterproof membrane.
Preferably, according to mass fraction, the component of moisture absorption pharmaceutical carrier includes：15-20 parts of moisturizing sustained release agent, borneol 1-2
Part, 0.5-1.5 parts of mint extract, 2-3 parts of glycerol, 8-10 parts of ethyl alcohol, 0.2-0.4 parts of bacteriostatic preservative, aromatic 0.1-0.3
Part.
It is further preferred that according to mass fraction, the component of moisture absorption pharmaceutical carrier includes：18 parts of moisturizing sustained release agent, borneol
1.5 parts, 0.9 part of mint extract, 2.3 parts of glycerol, 9 parts of ethyl alcohol, 0.3 part of bacteriostatic preservative, 0.2 part of aromatic.
Preferably, bacteriostatic peptide and methyl p-hydroxybenzoate are contained in bacteriostatic preservative, the mass ratio of the two is 1:7.
In the present invention, the preparation method of moisturizing sustained release agent includes the following steps：
(1) according to 4:1:It is molten that acrylic acid, Methacrylamide and methacrylic acid are mixed to get monomer by 2 molar ratio
Liquid, the sodium hydroxide that 25wt% is added dropwise into monomer solution neutralize monomer solution, will be in 250 parts according to mass fraction
Monomer solution with after is added in reaction kettle, and nitrogen atmosphere is passed through in reaction kettle and is protected, and reduces the dissolved oxygen amount in solution
To be not higher than 1ppm, then into reaction kettle be added 0.15g sodium peroxydisulfate, 0.1g L-AA salt, 4.2ml propylene glycol and
6.8ml alkyl phenol polyoxyethylene ether, and carry out initiated polymerization in conjunction with ultraviolet light irradiation, keep 80-85 DEG C of temperature polymerizations anti-
30-35min is answered, aquogel polymer A is obtained；
(2) the aquogel polymer A of upper step is sent to continuous cutting and crushing in multisection type roller pulverizer, be refined into
Partial size is the particle of 1mm, and particle is in drying machine with 170-180 DEG C of temperature, continuous heated-air drying 30-40min, general after drying
Grain object is sent in standard screen, and screening obtains the required powdery resin B that partial size is 250-550 μm；
(3) according to mass fraction, by 1.5 parts of ethylene glycol diglycidylethers, 0.8 part of methyl propanediol and 0.6 part of citron
Sour sodium is added in 15 parts of organic solvents, and dissolution is sufficiently stirred and obtains cross-linked modifier, and 80 parts of powdery resin B and 25 parts are formed sediment
Powder phosphate, which is added in batch mixer, stirs to get mixture, and modifying agent is then sprayed application to mixture in the way of spraying
In, and the mixed at high speed 8-15min on rotary mill, required cross-linking modified processing is completed, crosslinking needed for obtaining is compound
Object C；
(4) by 2.3 parts of fumed silicas, 1.5 parts of Alpha-aluminas and 4 parts of polyethyleneimines, 0.7 part of Imidamide is added
It into 25 parts of deionized waters, is stirred to obtain dispersion liquid, dispersion liquid is added in cross-linked composite C, continue rotary
3-5min is mixed in pulverizer, then mixture is sent on pneumatic drier, is heated and is dried with 150-200 DEG C of temperature
80-100min is handled, required moisturizing sustained release agent is obtained.
Wherein, the total mass fraction of solute three is 40-42.3% in the monomer solution of step (1).
Organic solvent in step (3) selects ethyl alcohol, propyl alcohol, isopropanol or acetone.
Preferably, waterproof membrane is polyethylene film or polypropylene screen.
Preferably, the region that substrate surface is located at moisture absorption pharmaceutical carrier is uniformly arranged Evapotranspiration hot hole, Evapotranspiration hot hole
Diameter is 0.8-1mm.
Retreat stickers sealed package provided by the invention, room temperature or cryo-conservation open packaging when use, first saturating with distilled water
It crosses on substrate and soaks moisture absorption pharmaceutical carrier at Evapotranspiration hot hole, be then pasted onto the forehead, temple or other parts of patient
Affected part.
The present invention has following beneficial effect：
There is the type retreat stickers good heat dissipation to bring down a fever effect, put up initial stage since the volatilization effect of alcohol is better than water, because
This first cold good cooling effect, later period are quick there is no need to be carried out using alcohol because patient temperature obtains a degree of control
Cooling, then radiated using the large quantity of moisture adsorbed in moisturizing sustained release agent, in addition, other than Evapotranspiration thermit powder, this hair
The refrigerant excitement also generated by borneol and mint extract in bright carrys out pathology impression when reduction of patient fever.
Moisturizing sustained release agent used in the present invention is one kind by polyacrylic resin, starch phosphate and other a variety of objects
The compound new material being prepared of matter has water suction performance of keeping humidity good, and good dispersion, property stablizes mild feature, as
The ethyl alcohol and moisture adsorbed when moisturizer use can play lasting cooling effect with slow evaporation；The gel obtained simultaneously
Solid content can effectively lock effective component therein, and effective component is avoided to be lost during sticking.
Wherein, the glycerol in moisture absorption pharmaceutical carrier component can play good skin care effect, avoid moist retreat stickers
The skin of patient is caused to stimulate or be damaged；Bacteriostatic preservative has good antibiotic and sterilizing effect, and retreat stickers is enabled to exist
Bacteriostasis is kept in the long-time use process of 18-24h, avoids wet environment from breeding bacterium and patient health is caused to damage.
And the Evapotranspiration hot hole on substrate can be improved moisture evaporation rate and improve cooling effect, after waterproof membrane can absorb water to avoid substrate
Adhesive force decline is fallen off.
Specific embodiment
Below with reference to embodiment, further description of the specific embodiments of the present invention, and following embodiment is only used for more
Technical solution of the present invention is clearly demonstrated, and not intended to limit the protection scope of the present invention.
In following embodiment, the preparation method of moisturizing sustained release agent includes the following steps：
(1) according to 4:1:It is molten that acrylic acid, Methacrylamide and methacrylic acid are mixed to get monomer by 2 molar ratio
Liquid, the sodium hydroxide that 25wt% is added dropwise into monomer solution neutralize monomer solution, will be in 250 parts according to mass fraction
Monomer solution with after is added in reaction kettle, and nitrogen atmosphere is passed through in reaction kettle and is protected, and reduces the dissolved oxygen amount in solution
To be not higher than 1ppm, then into reaction kettle be added 0.15g sodium peroxydisulfate, 0.1g L-AA salt, 4.2ml propylene glycol and
6.8ml alkyl phenol polyoxyethylene ether, and carry out initiated polymerization in conjunction with ultraviolet light irradiation, keep 80 DEG C of temperature polymerizations reaction
35min obtains aquogel polymer A；
(2) the aquogel polymer A of upper step is sent to continuous cutting and crushing in multisection type roller pulverizer, be refined into
Partial size is the particle of 1mm, and with 175 DEG C of temperature in drying machine, continuous heated-air drying 35min send particulate matter after dry particle
Enter into standard screen, screening obtains the required powdery resin B that partial size is 250-550 μm；
(3) according to mass fraction, by 1.5 parts of ethylene glycol diglycidylethers, 0.8 part of methyl propanediol and 0.6 part of citron
Sour sodium is added in 15 parts of organic solvents, and dissolution is sufficiently stirred and obtains cross-linked modifier, and 80 parts of powdery resin B and 25 parts are formed sediment
Powder phosphate, which is added in batch mixer, stirs to get mixture, and modifying agent is then sprayed application to mixture in the way of spraying
In, and the mixed at high speed 10min on rotary mill, required cross-linking modified processing is completed, required cross-linked composite is obtained
C；
(4) by 2.3 parts of fumed silicas, 1.5 parts of Alpha-aluminas and 4 parts of polyethyleneimines, 0.7 part of Imidamide is added
It into 25 parts of deionized waters, is stirred to obtain dispersion liquid, dispersion liquid is added in cross-linked composite C, continue rotary
5min is mixed in pulverizer, then mixture is sent on pneumatic drier, is heated and is dried with 180 DEG C of temperature
90min obtains required moisturizing sustained release agent.
Wherein, the total mass fraction of solute three is 41% in the monomer solution of step (1).
Organic solvent in step (3) selects ethyl alcohol.
Embodiment 1
A kind of retreat stickers of long-acting slow cooling, retreat stickers include the substrate prepared by non-woven fabrics from the bottom to top, in substrate
The moisture absorption pharmaceutical carrier of coating is entreated, the semi-transparency type film of pharmaceutical carrier surface covering and hygroscopic carrier periphery are in substrate surface
The pressure sensitive adhesive of coating is constituted；Region tow sides on substrate in addition to dilute moisture absorption pharmaceutical carrier are coated with waterproof membrane, pressure-sensitive
Glue is coated on waterproof membrane.
Wherein, according to mass fraction, the component of moisture absorption pharmaceutical carrier includes：15 parts of moisturizing sustained release agent, 1 part of borneol, peppermint
0.5 part of extract, 2 parts of glycerol, 8 parts of ethyl alcohol, 0.2 part of bacteriostatic preservative, 0.1 part of aromatic.
Contain bacteriostatic peptide and methyl p-hydroxybenzoate in bacteriostatic preservative, the mass ratio of the two is 1:7.
Waterproof membrane is polyethylene film.
The region that substrate surface is located at moisture absorption pharmaceutical carrier is uniformly arranged Evapotranspiration hot hole, and the diameter of Evapotranspiration hot hole is
0.8mm。
Retreat stickers sealed package provided in this embodiment, room temperature or cryo-conservation open packaging when use, first use distilled water
Through moisture absorption pharmaceutical carrier is soaked at Evapotranspiration hot hole on substrate, it is then pasted onto the forehead, temple or other offices of patient
Portion affected part.
Embodiment 2
A kind of retreat stickers of long-acting slow cooling, retreat stickers include the substrate prepared by non-woven fabrics from the bottom to top, in substrate
The moisture absorption pharmaceutical carrier of coating is entreated, the semi-transparency type film of pharmaceutical carrier surface covering and hygroscopic carrier periphery are in substrate surface
The pressure sensitive adhesive of coating is constituted；Region tow sides on substrate in addition to dilute moisture absorption pharmaceutical carrier are coated with waterproof membrane, pressure-sensitive
Glue is coated on waterproof membrane.
Wherein, according to mass fraction, the component of moisture absorption pharmaceutical carrier includes：20 parts of moisturizing sustained release agent, 2 parts of borneol, peppermint
1.5 parts of extract, 3 parts of glycerol, 10 parts of ethyl alcohol, 0.4 part of bacteriostatic preservative, 0.3 part of aromatic.
Contain bacteriostatic peptide and methyl p-hydroxybenzoate in bacteriostatic preservative, the mass ratio of the two is 1:7.
Waterproof membrane is polypropylene screen.
The region that substrate surface is located at moisture absorption pharmaceutical carrier is uniformly arranged Evapotranspiration hot hole, and the diameter of Evapotranspiration hot hole is
1mm。
Retreat stickers sealed package provided in this embodiment, room temperature or cryo-conservation open packaging when use, first use distilled water
Through moisture absorption pharmaceutical carrier is soaked at Evapotranspiration hot hole on substrate, it is then pasted onto the forehead, temple or other offices of patient
Portion affected part.
Embodiment 3
A kind of retreat stickers of long-acting slow cooling, retreat stickers include the substrate prepared by non-woven fabrics from the bottom to top, in substrate
The moisture absorption pharmaceutical carrier of coating is entreated, the semi-transparency type film of pharmaceutical carrier surface covering and hygroscopic carrier periphery are in substrate surface
The pressure sensitive adhesive of coating is constituted；Region tow sides on substrate in addition to dilute moisture absorption pharmaceutical carrier are coated with waterproof membrane, pressure-sensitive
Glue is coated on waterproof membrane.
Wherein, according to mass fraction, the component of moisture absorption pharmaceutical carrier includes：It is 18 parts of moisturizing sustained release agent, 1.5 parts of borneol, thin
0.9 part of lotus extract, 2.3 parts of glycerol, 9 parts of ethyl alcohol, 0.3 part of bacteriostatic preservative, 0.2 part of aromatic.
Contain bacteriostatic peptide and methyl p-hydroxybenzoate in bacteriostatic preservative, the mass ratio of the two is 1:7.
Waterproof membrane is polyethylene film.
The region that substrate surface is located at moisture absorption pharmaceutical carrier is uniformly arranged Evapotranspiration hot hole, and the diameter of Evapotranspiration hot hole is
0.9mm。
Retreat stickers sealed package provided in this embodiment, room temperature or cryo-conservation open packaging when use, first use distilled water
Through moisture absorption pharmaceutical carrier is soaked at Evapotranspiration hot hole on substrate, it is then pasted onto the forehead, temple or other offices of patient
Portion affected part.
Performance test
1, the cooling effect of retreat stickers is tested, the retreat stickers for selecting tester to put up the present embodiment on arm respectively produce
Product, and the ordinary fever paste product bought in the market is set as a control group；The cooling of test each group retreat stickers product is brought down a fever effect
Fruit, test result include the measurement result evaluation of body-sensing effect assessment and contactless thermometer；Wherein, temperature test result with
Shell temperature is lower than 2.5-10 DEG C of normal body temperature as the standard for judging that there is cooling to bring down a fever effect；Temperature measurement and body-sensing effect
A data acquisition was carried out every 2 hours, obtained following test result；
Table 1：The measure of merit data statistics of retreat stickers in the present embodiment
Analyze the discovery of above experimental result, bring down a fever duration of effect of the cooling of control group retreat stickers is 10h or so,
In within the effect phase of bringing down a fever, the cooling effect of body-sensing and actual measurement is more obvious, and the effect in the preceding 8h of retreat stickers of the invention
Fruit is consistent with control group, but within the time of 8-22h, body-sensing cooling effect is come with relatively unobvious from observed temperature
It sees, the reason of cooling effect of the type retreat stickers still remains, causes this variation judgement should be due to the wine in retreat stickers
Smart class drug has volatilized completely, serves as volatilization temperature reducing substance by the moisture in moisturizing sustained release agent, therefore may determine that the type moves back
The duration for burning the practical cooling effect of patch will be longer than the product of control group, and this effect is brought down a fever mainly due to of the invention
A kind of special moisturizing sustained release agent has been used in patch.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, although referring to aforementioned reality
Applying example, invention is explained in detail, for those skilled in the art, still can be to aforementioned each implementation
Technical solution documented by example is modified or equivalent replacement of some of the technical features.It is all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of retreat stickers of long-acting slow cooling, it is characterised in that：The retreat stickers include being prepared by non-woven fabrics from the bottom to top
Substrate, substrate center coating moisture absorption pharmaceutical carrier, pharmaceutical carrier surface covering semi-transparency type film and hygroscopic carrier week
While the pressure sensitive adhesive in substrate surface coating is constituted；Region tow sides on substrate in addition to dilute moisture absorption pharmaceutical carrier are coated with
Waterproof membrane, pressure sensitive adhesive are coated on waterproof membrane.
2. a kind of retreat stickers of long-acting slow cooling according to claim 1, it is characterised in that：According to mass fraction, institute
The component for stating moisture absorption pharmaceutical carrier includes：15-20 parts of moisturizing sustained release agent, 1-2 parts of borneol, 0.5-1.5 parts of mint extract, glycerol
2-3 parts, 8-10 parts of ethyl alcohol, 0.2-0.4 parts of bacteriostatic preservative, 0.1-0.3 parts of aromatic.
3. a kind of retreat stickers of long-acting slow cooling according to claim 2, it is characterised in that：According to mass fraction, institute
The component for stating moisture absorption pharmaceutical carrier includes：18 parts of moisturizing sustained release agent, 1.5 parts of borneol, 0.9 part of mint extract, 2.3 parts of glycerol,
9 parts of ethyl alcohol, 0.3 part of bacteriostatic preservative, 0.2 part of aromatic.
4. a kind of retreat stickers of long-acting slow cooling according to claim 2, it is characterised in that：In the bacteriostatic preservative
Containing bacteriostatic peptide and methyl p-hydroxybenzoate, the mass ratio of the two is 1:7.
5. a kind of retreat stickers of long-acting slow cooling according to claim 1, it is characterised in that：The moisturizing sustained release agent
Preparation method includes the following steps：
（1）According to 4:1:Acrylic acid, Methacrylamide and methacrylic acid are mixed to get monomer solution by 2 molar ratio, to
The sodium hydroxide that 25wt% is added dropwise in monomer solution neutralizes monomer solution, according to mass fraction, after 250 parts are neutralized
Monomer solution is added in reaction kettle, and nitrogen atmosphere is passed through in reaction kettle and is protected, and reduces the dissolved oxygen amount in solution to not high
In 1ppm, 0.15g sodium peroxydisulfate, 0.1g L-AA salt, 4.2ml propylene glycol and 6.8ml alkane are then added into reaction kettle
Base phenol polyethenoxy ether, and carry out initiated polymerization in conjunction with ultraviolet light irradiation, keep 80-85 DEG C of temperature polymerizations to react 30-
35min obtains aquogel polymer A；
（2）The aquogel polymer A of upper step is sent to continuous cutting and crushing in multisection type roller pulverizer, is refined into partial size
For the particle of 1mm, particle is in drying machine with 170-180 DEG C of temperature, continuous heated-air drying 30-40min, by particulate matter after drying
It is sent in standard screen, screening obtains the required powdery resin B that partial size is 250-550 μm；
（3）According to mass fraction, by 1.5 parts of ethylene glycol diglycidylethers, 0.8 part of methyl propanediol and 0.6 part of sodium citrate
It is added in 15 parts of organic solvents, dissolution is sufficiently stirred and obtains cross-linked modifier, by 80 parts of powdery resin B and 25 parts of starch phosphorus
Acid esters, which is added in batch mixer, stirs to get mixture, then sprays application to modifying agent in mixture in the way of spraying, and
The mixed at high speed 8-15min on rotary mill completes required cross-linking modified processing, obtains required cross-linked composite C；
（4）By 2.3 parts of fumed silicas, 1.5 parts of Alpha-aluminas and 4 parts of polyethyleneimines, 0.7 part of Imidamide are added to 25
It in part deionized water, is stirred to obtain dispersion liquid, dispersion liquid is added in cross-linked composite C, continuation is rotatably crushing
3-5min is mixed in machine, then mixture is sent on pneumatic drier, is heated and is dried with 150-200 DEG C of temperature
80-100min obtains required moisturizing sustained release agent.
6. a kind of retreat stickers of long-acting slow cooling according to claim 5, it is characterised in that：The step（1）List
The total mass fraction of solute three is 40-42.3% in liquid solution.
7. a kind of retreat stickers of long-acting slow cooling according to claim 5, it is characterised in that：The step（3）In
Organic solvent selects ethyl alcohol, propyl alcohol, isopropanol or acetone.
8. a kind of retreat stickers of long-acting slow cooling according to claim 1, it is characterised in that：The waterproof membrane is poly- second
Alkene film or polypropylene screen.
9. a kind of retreat stickers of long-acting slow cooling according to claim 1, it is characterised in that：The substrate surface is located at
The region of moisture absorption pharmaceutical carrier is uniformly arranged Evapotranspiration hot hole, and the diameter of Evapotranspiration hot hole is 0.8-1mm.
10. a kind of retreat stickers of long-acting slow cooling described in -9 any one according to claim 1, it is characterised in that：It is described
Retreat stickers sealed package, room temperature or cryo-conservation open packaging when use, first with distilled water through Evapotranspiration hot hole on substrate at
Moisture absorption pharmaceutical carrier is soaked, the forehead, temple or other local affected parts of patient are then pasted onto.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810853347.9A CN108815140A (en) | 2018-07-30 | 2018-07-30 | A kind of retreat stickers of long-acting slow cooling |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810853347.9A CN108815140A (en) | 2018-07-30 | 2018-07-30 | A kind of retreat stickers of long-acting slow cooling |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108815140A true CN108815140A (en) | 2018-11-16 |
Family
ID=64152278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810853347.9A Withdrawn CN108815140A (en) | 2018-07-30 | 2018-07-30 | A kind of retreat stickers of long-acting slow cooling |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108815140A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102049090A (en) * | 2010-12-20 | 2011-05-11 | 傅金龙 | Moxibustion patch and preparation method thereof |
| CN202920659U (en) * | 2012-10-13 | 2013-05-08 | 成都掌握移动信息技术有限公司 | Waterproof breathable medicament plaster |
| CN103224630A (en) * | 2013-05-16 | 2013-07-31 | 史学明 | Method for preparing water-absorbing resin by ultraviolet and gamma-ray radiation ionization technique |
| CN104337796A (en) * | 2014-10-12 | 2015-02-11 | 浙江欧洁科技股份有限公司 | Polymeric hydrogel fever cooling patch for children and preparation method thereof |
| CN204501190U (en) * | 2015-01-26 | 2015-07-29 | 青岛海诺生物工程有限公司 | Novel disk withdrawal heat posted |
| CN206198325U (en) * | 2016-08-22 | 2017-05-31 | 山东仁迪生物工程集团有限公司 | A kind of convenient drug paste |
| CN107814879A (en) * | 2017-10-23 | 2018-03-20 | 陕西品达石化有限公司 | A kind of surface is modified the preparation method of high hydroscopic resin |
-
2018
- 2018-07-30 CN CN201810853347.9A patent/CN108815140A/en not_active Withdrawn
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102049090A (en) * | 2010-12-20 | 2011-05-11 | 傅金龙 | Moxibustion patch and preparation method thereof |
| CN202920659U (en) * | 2012-10-13 | 2013-05-08 | 成都掌握移动信息技术有限公司 | Waterproof breathable medicament plaster |
| CN103224630A (en) * | 2013-05-16 | 2013-07-31 | 史学明 | Method for preparing water-absorbing resin by ultraviolet and gamma-ray radiation ionization technique |
| CN104337796A (en) * | 2014-10-12 | 2015-02-11 | 浙江欧洁科技股份有限公司 | Polymeric hydrogel fever cooling patch for children and preparation method thereof |
| CN204501190U (en) * | 2015-01-26 | 2015-07-29 | 青岛海诺生物工程有限公司 | Novel disk withdrawal heat posted |
| CN206198325U (en) * | 2016-08-22 | 2017-05-31 | 山东仁迪生物工程集团有限公司 | A kind of convenient drug paste |
| CN107814879A (en) * | 2017-10-23 | 2018-03-20 | 陕西品达石化有限公司 | A kind of surface is modified the preparation method of high hydroscopic resin |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103976886B (en) | Modified membrane cloth, preparation method and application thereof | |
| TWI611816B (en) | Water-soluble hyaluronic acid gel and preparation method thereof | |
| JP4067580B2 (en) | Freeze-dried biomatrix | |
| CN103494668B (en) | Medical hydrogel moisturizing eye care mask and preparation method thereof | |
| US20040156886A1 (en) | Sheet-like patch agent | |
| EP0750905A2 (en) | Patch comprising water soluble adhesive sheet | |
| Lin et al. | Preparation of pH-responsive avermectin/feather keratin-hyaluronic acid with anti-UV and sustained-release properties | |
| CN105125420B (en) | It is a kind of to be used to alleviate drug gel system of conventional transdermal problem and preparation method thereof | |
| WO2019061890A1 (en) | Preparation process for modified film fabric and application of modified film fabric | |
| CN109010263A (en) | A kind of invertibity liquid of super temperature change-gel transition reverse intelligent hydrogel and preparation method thereof | |
| JP2003070898A (en) | Plaster and production method thereof | |
| CN108815140A (en) | A kind of retreat stickers of long-acting slow cooling | |
| JPH03173831A (en) | Cosmetic or pharmaceutical composition | |
| KR20160055418A (en) | Cosmetic composition of customizable instant gel pack on skin | |
| CN109602897A (en) | A kind of flamazine temperature-sensitive hydrogel and preparation method thereof | |
| CN109010672A (en) | A kind of mosquito-repellent antipruritic Chinese medicine spray film and preparation method thereof | |
| CN203090245U (en) | Male contraception gel sticker | |
| Conti et al. | A proposed new method for the crosslinking of chitosan microspheres | |
| JPS6141926B2 (en) | ||
| US20210170068A1 (en) | A biphasic hydrogel formulation and methods of production and use thereof | |
| EP1583513A1 (en) | A topical skin-care formuation (tsf) and dipped elastomeric rubber polymer articles produced utilising the tsf | |
| KR101861555B1 (en) | The triple-layered hydrogel mask pack | |
| JPH03184922A (en) | Skin drug for external use | |
| KR102130482B1 (en) | Water Soluble Gel Sheets and Manufacturing method thereof | |
| CN110267646A (en) | For treating the medical device of HPV skin infection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181116 |