CN109010672A - A kind of mosquito-repellent antipruritic Chinese medicine spray film and preparation method thereof - Google Patents
A kind of mosquito-repellent antipruritic Chinese medicine spray film and preparation method thereof Download PDFInfo
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- CN109010672A CN109010672A CN201810926853.6A CN201810926853A CN109010672A CN 109010672 A CN109010672 A CN 109010672A CN 201810926853 A CN201810926853 A CN 201810926853A CN 109010672 A CN109010672 A CN 109010672A
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- 239000003814 drug Substances 0.000 title claims abstract description 105
- 239000007921 spray Substances 0.000 title claims abstract description 67
- 239000000077 insect repellent Substances 0.000 title claims abstract description 58
- 230000001139 anti-pruritic effect Effects 0.000 title claims abstract description 50
- 239000003908 antipruritic agent Substances 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 46
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- 235000019441 ethanol Nutrition 0.000 claims abstract description 24
- 239000008367 deionised water Substances 0.000 claims abstract description 22
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 22
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 21
- 239000007788 liquid Substances 0.000 claims abstract description 19
- 239000005714 Chitosan hydrochloride Substances 0.000 claims abstract description 15
- 238000003756 stirring Methods 0.000 claims abstract description 13
- 238000002156 mixing Methods 0.000 claims abstract description 10
- 238000004090 dissolution Methods 0.000 claims abstract description 9
- 238000011049 filling Methods 0.000 claims abstract description 8
- 239000000706 filtrate Substances 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims description 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 244000062241 Kaempferia galanga Species 0.000 claims description 8
- 235000013421 Kaempferia galanga Nutrition 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 240000004510 Agastache rugosa Species 0.000 claims description 7
- 244000246386 Mentha pulegium Species 0.000 claims description 7
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 7
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 7
- 240000000249 Morus alba Species 0.000 claims description 7
- 235000008708 Morus alba Nutrition 0.000 claims description 7
- 244000223014 Syzygium aromaticum Species 0.000 claims description 7
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 7
- 239000006260 foam Substances 0.000 claims description 7
- 235000001050 hortel pimenta Nutrition 0.000 claims description 7
- 239000001814 pectin Substances 0.000 claims description 7
- 229920001277 pectin Polymers 0.000 claims description 7
- 235000010987 pectin Nutrition 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 230000000694 effects Effects 0.000 abstract description 8
- 206010040880 Skin irritation Diseases 0.000 abstract description 3
- 230000000202 analgesic effect Effects 0.000 abstract description 3
- 231100000475 skin irritation Toxicity 0.000 abstract description 3
- 230000036556 skin irritation Effects 0.000 abstract description 3
- 239000003595 mist Substances 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 230000003020 moisturizing effect Effects 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000011521 glass Substances 0.000 description 17
- 241000700159 Rattus Species 0.000 description 11
- 238000005303 weighing Methods 0.000 description 10
- 239000000047 product Substances 0.000 description 8
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 7
- 230000014759 maintenance of location Effects 0.000 description 7
- 241000255925 Diptera Species 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 230000035699 permeability Effects 0.000 description 6
- 241000256113 Culicidae Species 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000001110 calcium chloride Substances 0.000 description 3
- 229910001628 calcium chloride Inorganic materials 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 230000008029 eradication Effects 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- NIQCNGHVCWTJSM-UHFFFAOYSA-N Dimethyl phthalate Chemical compound COC(=O)C1=CC=CC=C1C(=O)OC NIQCNGHVCWTJSM-UHFFFAOYSA-N 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000011047 acute toxicity test Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000002075 main ingredient Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000037311 normal skin Effects 0.000 description 2
- 230000001846 repelling effect Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- RWLALWYNXFYRGW-UHFFFAOYSA-N 2-Ethyl-1,3-hexanediol Chemical compound CCCC(O)C(CC)CO RWLALWYNXFYRGW-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- OKIJSNGRQAOIGZ-UHFFFAOYSA-N Butopyronoxyl Chemical compound CCCCOC(=O)C1=CC(=O)CC(C)(C)O1 OKIJSNGRQAOIGZ-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241000256059 Culex pipiens Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 244000062730 Melissa officinalis Species 0.000 description 1
- 235000010654 Melissa officinalis Nutrition 0.000 description 1
- MMOXZBCLCQITDF-UHFFFAOYSA-N N,N-diethyl-m-toluamide Chemical compound CCN(CC)C(=O)C1=CC=CC(C)=C1 MMOXZBCLCQITDF-UHFFFAOYSA-N 0.000 description 1
- 244000137852 Petrea volubilis Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- VXSIXFKKSNGRRO-MXOVTSAMSA-N [(1s)-2-methyl-4-oxo-3-[(2z)-penta-2,4-dienyl]cyclopent-2-en-1-yl] (1r,3r)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate;[(1s)-2-methyl-4-oxo-3-[(2z)-penta-2,4-dienyl]cyclopent-2-en-1-yl] (1r,3r)-3-[(e)-3-methoxy-2-methyl-3-oxoprop-1-enyl Chemical class CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)O[C@@H]1C(C)=C(C\C=C/C=C)C(=O)C1.CC1(C)[C@H](/C=C(\C)C(=O)OC)[C@H]1C(=O)O[C@@H]1C(C)=C(C\C=C/C=C)C(=O)C1 VXSIXFKKSNGRRO-MXOVTSAMSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229940023184 after bite Drugs 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000035617 depilation Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- FBSAITBEAPNWJG-UHFFFAOYSA-N dimethyl phthalate Natural products CC(=O)OC1=CC=CC=C1OC(C)=O FBSAITBEAPNWJG-UHFFFAOYSA-N 0.000 description 1
- 229960001826 dimethylphthalate Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 229960005082 etohexadiol Drugs 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- HYJYGLGUBUDSLJ-UHFFFAOYSA-N pyrethrin Natural products CCC(=O)OC1CC(=C)C2CC3OC3(C)C2C2OC(=O)C(=C)C12 HYJYGLGUBUDSLJ-UHFFFAOYSA-N 0.000 description 1
- 229940070846 pyrethrins Drugs 0.000 description 1
- 239000002728 pyrethroid Substances 0.000 description 1
- 238000013441 quality evaluation Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- 230000001988 toxicity Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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Abstract
The invention discloses a kind of mosquito-repellent antipruritic Chinese medicine spray film and preparation method thereof, one of mosquito-repellent antipruritic Chinese medicine sprays film, and raw material is Chinese medical extract.A kind of preparation method of mosquito-repellent antipruritic Chinese medicine spray film, comprises the following steps that: (1) taking Chinese medicine that ethyl alcohol is added and impregnate at room temperature 12 hours, filter, discard filter residue, filtrate is suitably concentrated, and obtains Chinese medicine extract；(2) it weighs PVA1788 and chitosan hydrochloride, is added appropriate amount of deionized water, stirring is to being completely dissolved；Modifying agent is added, continues stirring and is allowed to dissolution completely；(3) Chinese medicine extract obtained by step (1) is added, 100ml is settled to deionized water after mixing, stirs evenly, obtains the transparent spray film liquid of yellowish green, it is filling in suitable spray bottle.A kind of mosquito-repellent antipruritic Chinese medicine that the present invention obtains sprays film, it is sprayed with mist, it is dried to colourless to yellowish film rapidly on the skin, not only there is mosquito-prevention mosquito-repellent effect, there are also antipruritic analgesic effect, have easy to carry, preparation method is simple, moisturizing is ventilative, the characteristics of to no skin irritation and toxic side effect.
Description
Technical field:
The present invention relates to daily-use chemical industry technical field, in particular relate to a kind of Chinese medicine spray film with mosquito-repellent antipruritic effect and
Preparation method.
Background technique:
Two season of summer and autumn is mosquito more season, not only will cause pruitus after bite by mosquitos, can also propagate various diseases
Disease influences human health, and therefore, various mosquito repellent articles are two season of summer and autumn necessary articles.Traditional mosquito repellent, mosquito eradication mode have mosquito-repellent incense,
Mosquito eradication is spraying and mosquito repellent liquid etc..Mosquito-repellent incense and mosquito eradication need use in confined space for 1-2 hours in advance by spraying, effect exterminating mosquito compared with
It is good, but in the outdoor or preferable region of air circulation, it is difficult performance and effect is effectively protected.Therefore at present it is most commonly used still
It can be directly used for the various mosquito repellent products of skin, but as this kind of product such as mosquito-repellent perfume, mosquito-repellent water will soon for skin
It volatilizees or volatilizes, constantly spraying is needed just to be able to maintain repelling effect.Novel mosquito repellent is had developed to improve repelling effect people
Product, such as mosquito-driving condensation dew, mosquito repellent balm, mosquito-dispelling cream, these products are not volatile, and retention time is long on the skin, mosquito repellent effect
Fruit rises appreciably, but needs to be applied on skin when medication, inconvenient to use, and can be infected with clothing in daily activities or be rubbed
It removes, effect is often not satisfactory.
Summary of the invention:
In order to overcome the deficiencies in the prior art, the purpose of the present invention is to provide a kind of sprays of mosquito-repellent antipruritic Chinese medicine
Film, specifically one kind is avoided that bite by mosquitos, at the same to by bite by mosquitos skin have analgesic, itching-relieving action spray film and
Preparation method.Spray-filming agent is the new formulation of a kind of combination film in field of pharmaceutical preparations, spray advantage, its main feature is that with
Mist sprays rapid drying and forming-film on the skin, not easily to fall off to be infected with clothing, can extend drug release time, enhances drug effect.
The purpose of the invention is achieved by the following technical solution: a kind of mosquito-repellent antipruritic Chinese medicine sprays film, it is characterised in that by with
The material composition of lower quality percent by volume forms:
Chinese medicine extract: 20~70%
Chitosan hydrochloride: 0.1~5.0%
PVA1788:0.1~5.0%
Modifying agent: 1.0~10.0%
Deionized water: surplus
A kind of Chinese medicine with mosquito-repellent antipruritic effect sprays film.It is characterized in that, Chinese medicine used in Chinese medicine extract is
One or more of medicinal materials such as kaempferia galanga and mulberry leaf, peppermint, cloves, wrinkled giant hyssop are composed.
The Chinese medicine extract the preparation method is as follows: above-mentioned medicinal material according to 1:1 ratio take in right amount, according to 40:1~
Ethyl alcohol is added in the ratio of 60:1, impregnates 12 hours at room temperature, filtering, discards filter residue, filtrate be suitably concentrated to get.
The traditional Chinese medicine extraction liquid and preparation method thereof of a kind of mosquito-repellent antipruritic Chinese medicine spray film, it is characterised in that ethyl alcohol used is doctor
With grade ethyl alcohol, concentration is 90~100%, and further concentration of alcohol is preferably 95%.
A kind of mosquito-repellent antipruritic Chinese medicine sprays film.It is characterized in that, the modifying agent is selected from glycerol, propylene glycol, pectin
The mixing of middle one or more, the pectin are extraordinary low-ester pectin.
A kind of preparation method of mosquito-repellent antipruritic Chinese medicine spray film, key are following processing step:
(1) weigh PVA1788 and chitosan hydrochloride, appropriate amount of deionized water be added, stirred under 40 DEG C of water bath conditions to
It is completely dissolved；Modifying agent is added, continues stirring and is allowed to dissolution completely, place to room temperature and wait for the removal of foam；
(2) Chinese medicine extract as described above is added, is settled to 100ml with distilled water after mixing, is stirred evenly, micro- Huang is obtained
Green transparent sprays film liquid, filling in suitable spray bottle.
The present invention using Chinese medical extract as main ingredient, avoid using pyrethrins mosquitofugal oil common in current mosquito repellent product,
The chemicals such as dimethyl phthalate, dihydropyrone, octylene glycol, Metadelphene, the toxicity for reducing the irritation to skin and being likely to occur；Select tool
Having obvious analgesia, anti-inflammatory, insecticidal action kaempferia galanga is main ingredient, is aided with common mosquito repellent Chinese medicine, makes the present invention not only with conventional
The mosquito-prevention mosquito-repellent of mosquito repellent product acts on, to also having antipruritic analgesic effect by the skin of bite by mosquitos.
Compared with the prior art, beneficial effects of the present invention are as follows: with other mosquito expelling products such as mosquito-dispelling cream, culicifuge incense
The characteristics of cream, mosquito-driving condensation dew (or gel) etc. are compared, and the present invention has rate of drying fast, are not infected with clothing, good permeability.This hair
Bright preparation method is simple, easy to operate, at low cost, is suitable for industrialized production.
One, a kind of safety evaluatio of mosquito-repellent antipruritic Chinese medicine spray film
1. acute toxicity test
Referring to chemicals acute toxicity test technological guidance's principle, healthy SD rat 32 are taken, is randomly divided into 4 groups, i.e.,
Intact skin administration group, damaged skin administration group, intact skin bare substrate group and damaged skin bare substrate group.Before administration
For 24 hours, more solito loses hair or feathers, damaged skin group sand paper abraded skin.Successive administration 7d observes the daily behavior performance of rat
And death condition.
Acute toxicity testing result is shown in attached drawing (by taking the 1st day and the 7th day skin conditions of rat as an example).Medicine film is to complete skin
Skin group does not influence, and also has no and significantly affects to damaged skin group, and damaged skin group rat starts to form a scab on day 3, administration the 7th
It is almost recovered；The crawler behavior of four groups of rats is normal within the observation period, and medicine film is to its coat gloss, diet, excrement and body
It is again equal not have an impact, do not occur rats death phenomenon yet.It is acute to show that mosquito-expelling and antipruritic Chinese medicine spray film external application does not generate rat
Toxic reaction.
2. skin irritation, sensitivity test
Referring to Chemical induced irritation, anaphylaxis and hemolytic investigative technique guideline, healthy SD rat 16 are chosen,
It is randomly divided into intact skin group and damaged skin group.Using the conventional coat for taking off rat back backbone two sides.Respectively same
Dosing film and bare substrate film are applied at rat depilation.Remove film after coating 6h, after striping for 24 hours, 48h and 72h naked eyes see
Situations such as examining coating whether there is or not erythema and oedema at position.
Skin irritation the results show that each group rat after medication 24,48, that 72h does not occur erythema or oedema is existing
As to spray film nonirritant to normal skin and damaged skin for, mosquito-expelling and antipruritic Chinese medicine, also to cause allergic reaction.
Two, mosquito-expelling and antipruritic Chinese medicine spray film quality evaluation
1.pH value
With reference to the guideline in " Chinese Pharmacopoeia " 2015 editions the 4th, according to pH value measuring method, measures and prepared spray film medicine
The pH value of liquid.
Evaluation results are shown in Table 1 by medicine film pH.Three batches of spray film mean ph values are between 4.59~4.74, human skin surface's pH value
Between 4.5~6.5, which will not generate obvious stimulation to human skin within the scope of normal skin pH.
The pH value of 1 three batches of mosquito-expelling and antipruritic Chinese medicine spray-filming agents of table
2. hygroscopicity
It weighs after taking standard glass slide to dry, takes a kind of spray of mosquito-repellent antipruritic Chinese medicine described in 0.3ml film liquid on a glass
It smears uniformly, and dries film forming in 37 DEG C of baking ovens, film is cut into the square that side length is 25mm, together with glass slide in 45 DEG C
Baking oven in dry to constant weight, claim the gross weight of glass slide and film.Glass slide and film are put into again and are equipped with the close of saturation NaCl solution
It seals in container, stands overnight at room temperature.Film and glass slide are taken out afterwards for 24 hours, then weigh the gross weight of film and glass slide, is then weighed
The weight of blank slide.6 groups of data are measured in parallel, hygroscopicity δ is calculated as follows:
δ=(M2-M1)/(M1- M) × 100%
In formula, δ: film hygroscopicity, %；M: the quality of blank slide, g；M1: when first time glass slide and film drying to constant weight
Gross mass, g；M2: the gross mass of glass slide and film, g after moisture absorption for 24 hours.
3. moisture retention
A kind of mosquito-repellent antipruritic Chinese medicine spray film liquid is smeared uniformly on glass slide, and is formed a film in 37 DEG C of drying, at
Film is cut to the square for becoming side length 25mm after film, film is dried in 45 DEG C of baking oven to constant weight together with glass slide, will be carried
Slide and film, which are put in, is equipped with saturation K2CO3It in the closed container of solution, stands overnight at room temperature, takes out film and glass slide afterwards for 24 hours,
Surface moisture is blotted with filter paper, is weighed.Film and glass slide are put into the closed container for being equipped with anhydrous calcium chloride again, for 24 hours after
It takes the film out, weighs.It dries finally, glass slide and film are placed in 45 DEG C of baking ovens to constant weight, takes out weighing.It is measured in parallel 6 groups
Moisture retention ω is calculated as follows in data:
ω=(M2-M3)/(M1-M3) × 100%
In formula, ω: film moisture retention, %；M1: the gross mass of moisture absorption caudacoria and glass slide for 24 hours, g；M2: dry caudacoria for 24 hours and load glass
The gross mass of piece, g；M3: the gross mass of constant weight caudacoria and glass slide, g.
4. gas permeability
Two weighing bottles (25mm × 25mm) are taken, 2g anhydrous calcium chloride is separately added into.It will be in a kind of mosquito-repellent antipruritic
Medicine spray film is cut to be suitable for size, seals one of weighing bottle, weighs the total of sealer group medicine film, weighing bottle and anhydrous calcium chloride
The total weight of weight and control group weighing bottle and anhydrous calcium chloride；Two weighing bottles are put into and are equipped with saturation NaCl solution
It in closed container, places take out afterwards for 24 hours at room temperature, claim two groups of weight respectively.6 groups of effective data are measured in parallel, are counted as the following formula
Calculate gas permeability
In formula,Gas permeability, %；M1: sealer group weighing bottle, medicine film and calcium chloride gross mass, g；M2: control group weighing bottle and chlorine
Change calcium gross mass, g；M3: ventilative sealer group weighing bottle rear for 24 hours, medicine film and calcium chloride gross mass, g；M4: ventilative control group rear for 24 hours
Weighing bottle and calcium chloride gross mass, g.
Medicine film hygroscopicity, moisture retention and gas permeability evaluation result are shown in Table 2.The hygroscopicity of film is 49.29%, and moisture retention is
35.11%, gas permeability 96.34% shows that the film for skin surface, can keep skin wet, and will not influence skin
Pore it is normal ventilated.
2 mosquito-expelling and antipruritic Chinese medicine spray-filming agent hygroscopicity of table, moisture retention, ventilation characteristic measuring result
5. film formation time
Spray film is sprayed on healthy human body skin, can be considered film forming when film is tack-free.
The results are shown in Table 3, which is sprayed on skin, waits 3~5min that can form a film, will not be infected with clothing, Bu Huiying
Ring daily normal activity.
The film formation time of 3 mosquito-expelling and antipruritic Chinese medicine spray-filming agent of table
Detailed description of the invention:
Fig. 1 acute toxicity testing skin figure (wherein I: damaged skin administration group；II: intact skin administration group；III:
Intact skin matrix group；IV: damaged skin matrix group)
Specific embodiment:
Below with reference to specific embodiment, the further detailed description present invention.It should be understood that these embodiments are intended merely to
It illustrates the present invention, rather than limits the scope of the invention in any way.Term as used in the present invention, unless there are another
External declaration generally has the normally understood meaning of those of ordinary skill in the art.It is any to meet the claims or specification
Description, meet with principles disclosed herein and novelty, the method for inventive features, technique, product, each fall within of the invention
Within protection scope.
Embodiment 1:
A kind of mosquito-repellent antipruritic Chinese medicine spray film, is made of the material composition of following quality percent by volume:
Chinese medicine extract: 70%
Chitosan hydrochloride: 0.35%
PVA1788:1.5%
Glycerol (modifying agent): 4.0%
Deionized water: surplus
A kind of Chinese medicine with mosquito-repellent antipruritic effect sprays film.It is characterized in that, Chinese medicine used in Chinese medicine extract is
One or more of medicinal materials such as kaempferia galanga and mulberry leaf, peppermint, cloves, wrinkled giant hyssop are composed.
The Chinese medicine extract is the preparation method is as follows: above-mentioned medicinal material is taken in right amount according to 1:1 ratio, according to the ratio of 60:1
Ethyl alcohol is added in example, impregnates 12 hours at room temperature, and filtering discards filter residue, filtrate be concentrated into 70ml to get.
The traditional Chinese medicine extraction liquid and preparation method thereof of a kind of mosquito-repellent antipruritic Chinese medicine spray film, it is characterised in that ethyl alcohol used is doctor
With grade ethyl alcohol, concentration 90%.
A kind of preparation method of mosquito-repellent antipruritic Chinese medicine spray film, key are following processing step:
(1) weigh PVA1788 and chitosan hydrochloride, appropriate amount of deionized water be added, stirred under 40 DEG C of water bath conditions to
It is completely dissolved；Modifying agent is added, continues stirring and is allowed to dissolution completely, place to room temperature and wait for the removal of foam；
(2) it is appropriate to add the Chinese medicine extract, is settled to 100ml with deionized water after mixing, stirs evenly, obtains micro-
The transparent spray film liquid of yellow green, it is filling in suitable spray bottle.
Embodiment 2:
A kind of mosquito-repellent antipruritic Chinese medicine spray film, is made of the material composition of following quality percent by volume:
Chinese medicine extract: 50%
Chitosan hydrochloride: 0.4%
PVA1788:1.8%
Glycerol (modifying agent): 4.0%
Deionized water: surplus
A kind of Chinese medicine with mosquito-repellent antipruritic effect sprays film.It is characterized in that, Chinese medicine used in Chinese medicine extract is
One or more of medicinal materials such as kaempferia galanga and mulberry leaf, peppermint, cloves, wrinkled giant hyssop are composed.
The Chinese medicine extract is the preparation method is as follows: above-mentioned medicinal material is taken in right amount according to 1:1 ratio, according to the ratio of 50:1
Ethyl alcohol is added in example, impregnates 12 hours at room temperature, and filtering discards filter residue, filtrate be concentrated into 50ml to get.
The traditional Chinese medicine extraction liquid and preparation method thereof of a kind of mosquito-repellent antipruritic Chinese medicine spray film, it is characterised in that ethyl alcohol used is doctor
With grade ethyl alcohol, concentration 95%.
A kind of preparation method of mosquito-repellent antipruritic Chinese medicine spray film, key are following processing step:
(1) weigh PVA1788 and chitosan hydrochloride, appropriate amount of deionized water be added, stirred under 40 DEG C of water bath conditions to
It is completely dissolved；Modifying agent is added, continues stirring and is allowed to dissolution completely, place to room temperature and wait for the removal of foam；
(2) it is appropriate to add the Chinese medicine extract, is settled to 100ml with deionized water after mixing, stirs evenly, obtains micro-
The transparent spray film liquid of yellow green, it is filling in suitable spray bottle.
Embodiment 3:
A kind of mosquito-repellent antipruritic Chinese medicine spray film, is made of the material composition of following quality percent by volume:
Chinese medicine extract: 30%
Chitosan hydrochloride: 0.4%
PVA1788:1.75%
Low-ester pectin (modifying agent): 7.0%
Deionized water: surplus
A kind of Chinese medicine with mosquito-repellent antipruritic effect sprays film.It is characterized in that, Chinese medicine used in Chinese medicine extract is
One or more of medicinal materials such as kaempferia galanga and mulberry leaf, peppermint, cloves, wrinkled giant hyssop are composed.
The Chinese medicine extract is the preparation method is as follows: above-mentioned medicinal material is taken in right amount according to 1:1 ratio, according to the ratio of 40:1
Ethyl alcohol is added in example, impregnates 12 hours at room temperature, and filtering discards filter residue, filtrate be concentrated into 30ml to get.
The traditional Chinese medicine extraction liquid and preparation method thereof of a kind of mosquito-repellent antipruritic Chinese medicine spray film, it is characterised in that ethyl alcohol used is doctor
With grade ethyl alcohol, concentration 100%.
A kind of preparation method of mosquito-repellent antipruritic Chinese medicine spray film, key are following processing step:
(1) weigh PVA1788 and chitosan hydrochloride, appropriate amount of deionized water be added, stirred under 40 DEG C of water bath conditions to
It is completely dissolved；Modifying agent is added, continues stirring and is allowed to dissolution completely, place to room temperature and wait for the removal of foam；
(2) Chinese medicine extract is added, is settled to 100ml with deionized water after mixing, is stirred evenly, is obtained micro- yellowish green
The transparent spray film liquid of color, it is filling in suitable spray bottle.
Embodiment 4:
A kind of mosquito-repellent antipruritic Chinese medicine spray film, is made of the material composition of following quality percent by volume:
Chinese medicine extract: 70%
Chitosan hydrochloride: 0.4%
PVA1788:1.8%
Propylene glycol (modifying agent): 1.0%
Deionized water: surplus
A kind of Chinese medicine with mosquito-repellent antipruritic effect sprays film.It is characterized in that, Chinese medicine used in Chinese medicine extract is
One or more of medicinal materials such as kaempferia galanga and mulberry leaf, peppermint, cloves, wrinkled giant hyssop are composed.
The Chinese medicine extract is the preparation method is as follows: above-mentioned medicinal material is taken in right amount according to 1:1 ratio, according to the ratio of 60:1
Ethyl alcohol is added in example, impregnates 12 hours at room temperature, and filtering discards filter residue, filtrate be concentrated into 70ml to get.
The traditional Chinese medicine extraction liquid and preparation method thereof of a kind of mosquito-repellent antipruritic Chinese medicine spray film, it is characterised in that ethyl alcohol used is doctor
With grade ethyl alcohol, concentration 90%.
A kind of preparation method of mosquito-repellent antipruritic Chinese medicine spray film, key are following processing step:
(1) weigh PVA1788 and chitosan hydrochloride, appropriate amount of deionized water be added, stirred under 40 DEG C of water bath conditions to
It is completely dissolved；Modifying agent is added, continues stirring and is allowed to dissolution completely, place to room temperature and wait for the removal of foam；
(2) Chinese medicine extract is added, is settled to 100ml with deionized water after mixing, is stirred evenly, is obtained micro- yellowish green
The transparent spray film liquid of color, it is filling in suitable spray bottle.
Embodiment 5:
A kind of mosquito-repellent antipruritic Chinese medicine spray film, is made of the material composition of following quality percent by volume:
Chinese medicine extract: 45%
Chitosan hydrochloride: 0.25%
PVA1788:1.25%
Glycerol (modifying agent): 5.75%
Deionized water: surplus
A kind of Chinese medicine with mosquito-repellent antipruritic effect sprays film.It is characterized in that, Chinese medicine used in Chinese medicine extract is
One or more of medicinal materials such as kaempferia galanga and mulberry leaf, peppermint, cloves, wrinkled giant hyssop are composed.
The Chinese medicine extract is the preparation method is as follows: above-mentioned medicinal material is taken in right amount according to 1:1 ratio, according to the ratio of 50:1
Ethyl alcohol is added in example, impregnates 12 hours at room temperature, and filtering discards filter residue, filtrate be concentrated into 45ml to get.
The traditional Chinese medicine extraction liquid and preparation method thereof of a kind of mosquito-repellent antipruritic Chinese medicine spray film, it is characterised in that ethyl alcohol used is doctor
With grade ethyl alcohol, concentration 95%.
A kind of preparation method of mosquito-repellent antipruritic Chinese medicine spray film, key are following processing step:
(1) weigh PVA1788 and chitosan hydrochloride, appropriate amount of deionized water be added, stirred under 40 DEG C of water bath conditions to
It is completely dissolved；Modifying agent is added, continues stirring and is allowed to dissolution completely, place to room temperature and wait for the removal of foam；
(2) it is appropriate to add Chinese medicine extract as described above, is settled to 100ml with deionized water after mixing, stirs evenly,
The transparent spray film liquid of yellowish green is obtained, it is filling in suitable spray bottle.
Claims (5)
1. a kind of mosquito-repellent antipruritic Chinese medicine sprays film, it is characterised in that be made of the material composition of following quality percent by volume:
Chinese medicine extract: 20~70%
Chitosan hydrochloride: 0.1~5.0%
PVA1788:0.1~5.0%
Modifying agent: 1.0~10.0%
Deionized water: surplus.
2. a kind of mosquito-repellent antipruritic Chinese medicine according to claim 1 sprays film.It is characterized in that, Chinese medicine used in Chinese medicine extract is
One or more of medicinal materials such as kaempferia galanga and mulberry leaf, peppermint, cloves, wrinkled giant hyssop are composed.Chinese medicine extract the preparation method is as follows:
Above-mentioned medicinal material is taken in right amount according to 1:1 ratio, and ethyl alcohol is added according to the ratio of 40:1~60:1, impregnates 12 hours at room temperature, mistake
Filter, discards filter residue, filtrate be suitably concentrated to get.
3. the traditional Chinese medicine extraction liquid and preparation method thereof in a kind of mosquito-repellent antipruritic Chinese medicine spray film according to claim 2.Its feature exists
It is medical grade ethyl alcohol in ethyl alcohol used, concentration is 90~100%, and wherein concentration of alcohol is preferably 95%.
4. a kind of mosquito-repellent antipruritic Chinese medicine according to claim 1 sprays film.It is characterized in that, the modifying agent be selected from glycerol,
One or more of mixing in propylene glycol, pectin, the pectin are extraordinary low-ester pectin.
5. a kind of preparation method of mosquito-repellent antipruritic Chinese medicine spray film as described in claim 1, it is characterised in that walked including following technique
It is rapid:
(1) PVA1788 and chitosan hydrochloride are weighed, appropriate amount of deionized water is added, is stirred under 40 DEG C of water bath conditions to complete
Dissolution；
(2) modifying agent is added, continues stirring and is allowed to dissolution completely, place to room temperature and wait for the removal of foam；
(3) Chinese medicine extract is added, is settled to 100ml with deionized water after mixing, is stirred evenly, the transparent spray of yellowish green is obtained
Film liquid, it is filling in suitable spray bottle.
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Application publication date: 20181218 |