CN109010086A - A kind of anti-Sai nti-freckle Chinese medicine spray film and preparation method thereof - Google Patents
A kind of anti-Sai nti-freckle Chinese medicine spray film and preparation method thereof Download PDFInfo
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- CN109010086A CN109010086A CN201810926819.9A CN201810926819A CN109010086A CN 109010086 A CN109010086 A CN 109010086A CN 201810926819 A CN201810926819 A CN 201810926819A CN 109010086 A CN109010086 A CN 109010086A
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- sai
- nti
- film
- chinese medicine
- poria alba
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- 239000007921 spray Substances 0.000 title claims abstract description 58
- 239000003814 drug Substances 0.000 title claims abstract description 52
- 208000003351 Melanosis Diseases 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 41
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 30
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 30
- 239000000843 powder Substances 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000000284 extract Substances 0.000 claims abstract description 27
- 239000008367 deionised water Substances 0.000 claims abstract description 23
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 23
- 235000019441 ethanol Nutrition 0.000 claims abstract description 20
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 19
- 239000000463 material Substances 0.000 claims abstract description 18
- 239000005714 Chitosan hydrochloride Substances 0.000 claims abstract description 16
- 238000003756 stirring Methods 0.000 claims abstract description 15
- 239000007788 liquid Substances 0.000 claims abstract description 13
- 229960004756 ethanol Drugs 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 11
- 229960000935 dehydrated alcohol Drugs 0.000 claims abstract description 10
- 238000011049 filling Methods 0.000 claims abstract description 8
- 239000000706 filtrate Substances 0.000 claims abstract description 8
- 239000003595 mist Substances 0.000 claims abstract description 4
- 235000013422 Kaempferia rotunda Nutrition 0.000 claims abstract description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 239000001814 pectin Substances 0.000 claims description 7
- 229920001277 pectin Polymers 0.000 claims description 7
- 235000010987 pectin Nutrition 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 6
- 238000000498 ball milling Methods 0.000 claims description 2
- 238000004891 communication Methods 0.000 claims description 2
- 244000062250 Kaempferia rotunda Species 0.000 claims 1
- 125000005909 ethyl alcohol group Chemical group 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 16
- 244000062241 Kaempferia galanga Species 0.000 abstract description 12
- 235000013421 Kaempferia galanga Nutrition 0.000 abstract description 11
- 238000005507 spraying Methods 0.000 abstract description 4
- 241000395033 Kaempferia Species 0.000 abstract description 2
- 206010040880 Skin irritation Diseases 0.000 abstract description 2
- 239000002075 main ingredient Substances 0.000 abstract description 2
- 231100000475 skin irritation Toxicity 0.000 abstract description 2
- 230000036556 skin irritation Effects 0.000 abstract description 2
- 206010059516 Skin toxicity Diseases 0.000 abstract 1
- 230000003020 moisturizing effect Effects 0.000 abstract 1
- 231100000438 skin toxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 238000005303 weighing Methods 0.000 description 16
- 241000700159 Rattus Species 0.000 description 10
- 239000011521 glass Substances 0.000 description 8
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 7
- 238000004090 dissolution Methods 0.000 description 7
- 230000014759 maintenance of location Effects 0.000 description 7
- 229940079593 drug Drugs 0.000 description 6
- 230000035699 permeability Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 244000197580 Poria cocos Species 0.000 description 3
- 235000008599 Poria cocos Nutrition 0.000 description 3
- 239000001110 calcium chloride Substances 0.000 description 3
- 229910001628 calcium chloride Inorganic materials 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 239000000516 sunscreening agent Substances 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 238000011047 acute toxicity test Methods 0.000 description 2
- 208000030961 allergic reaction Diseases 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 230000037311 normal skin Effects 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- 206010027146 Melanoderma Diseases 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 241000287127 Passeridae Species 0.000 description 1
- 244000137852 Petrea volubilis Species 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 241000234314 Zingiber Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000035617 depilation Effects 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 238000013441 quality evaluation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0204—Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of anti-Sai nti-freckle Chinese medicine spray films and preparation method thereof.Spraying film composition includes main ingredient kaempferia galanga and PORIA ALBA and film forming auxiliary material PVA1788 and chitosan hydrochloride etc..A kind of preparation method of anti-Sai nti-freckle Chinese medicine spray film, comprising the following steps: (1) kaempferia galanga is added ethyl alcohol and impregnates at room temperature 12 hours, and filtrate is concentrated to dryness to obtain kaempferia galamga extract；PORIA ALBA is smashed into micropowders.(2) deionized water is added in PVA1788 and chitosan hydrochloride, is stirred at 40 DEG C to being completely dissolved；Step (1) described Rhizoma Kaempferiae extract and PORIA ALBA Ultramicro-powder is added, adds modifying agent, stirring is added dehydrated alcohol and deionized water, mixes to obtain colourless to yellowish transparent spray film liquid to after dissolving completely.Anti- Sai nti-freckle Chinese medicine that the present invention obtains sprays film, is sprayed in filling spray bottle with mist, can be dried to colorless and transparent film rapidly on the skin, can prevent that skin Sai is black, there are also effect of dispelling spots for Sai wound.With easy to carry, moisturizing is ventilative, the characteristics of to no skin irritation and toxicity.
Description
Technical field:
The present invention relates to daily-use chemical industry technical field, in particular relate to a kind of Chinese medicine spray film with anti-Sai effect of dispelling spots and
Preparation method.
Background technique:
Recently as the continuous expansion of Ozone hole in greenhouse effects aggravation and atmosphere, sunlight is irradiated to mankind's skin
The influence of skin is also more and more obvious, and especially in two season of summer and autumn, the sun is sinister, ultraviolet light also than stronger, skin by tanned or
Person Sai wound, or pigmentation occur, or even dermatitis, cutaneum carcinoma can occur etc..Therefore, various anti-Sai nti-freckle products are summer and autumn two
Season necessary article.Traditional anti-Sai nti-freckle product is mainly various anti-Sai spraying, anti-Sai lotion and suncream etc..Anti- Sai it is spraying and
Anti- Sai lotion will soon volatilize or volatilize for skin, and constantly spraying is needed just to be able to maintain anti-Sai effect；Suncream is not easy to wave
Hair, retention time is long on the skin, and anti-Sai effect is obvious, but because being creams quality, painting is sticky thick and heavy on the skin, influences hair
Hole breathing；It is also easy to whiten, mix after especially perspiring with sweat, be easy to appear " paint face " phenomenon, effect is often not
It is ideal.
Summary of the invention:
In order to overcome the deficiencies in the prior art, the purpose of the present invention is to provide a kind of anti-Sai nti-freckle Chinese medicines to spray
Film, specifically one kind is avoided that skin is hurt by tanned Sai, while having light spot, effect of dispelling spots to the skin for Sai spot occurred
Spray film and preparation method thereof.Spray-filming agent is the new formulation of a kind of combination film in field of pharmaceutical preparations, spray advantage, special
Point is that rapid drying and forming-film on the skin is sprayed with mist, not easily to fall off, can extend drug release time, enhance drug effect.
The purpose of the invention is achieved by the following technical solution: a kind of anti-Sai nti-freckle Chinese medicine sprays film, it is characterised in that by with
The material composition of lower quality percent by volume forms:
Rhizoma Kaempferiae extract: 0.1~2.0%
Poria alba powder: 0.1~1.0%
Chitosan hydrochloride: 0.1~5.0%
PVA1788:0.1~5.0%
Modifying agent: 1.0~10.0%
Dehydrated alcohol: 20~70%
Deionized water: surplus
A kind of anti-Sai nti-freckle Chinese medicine sprays film.It is characterized in that, the Rhizoma Kaempferiae extract is ethanol extract.It is made
Preparation Method is as follows: kaempferia galamga medicinal material is taken in right amount, and ethyl alcohol is added according to the ratio of 5:1~20:1, impregnates 12 hours at room temperature, mistake
Filter, discards filter residue, filtrate be concentrated to dryness to get.
The Rhizoma Kaempferiae extract preparation method, which is characterized in that ethyl alcohol used be medical grade ethyl alcohol, concentration be 90~
100%, further concentration of alcohol is preferably 95%.
A kind of anti-Sai nti-freckle Chinese medicine sprays film.It is characterized in that, the poria alba powder is Ultramicro-powder.Preparation method
It is as follows: PORIA ALBA medicinal material being cleaned, is dried.It is first tentatively crushed, is sieved with 100 mesh sieve, obtain PORIA ALBA coarse powder, then carry out ultra micro
It crushes, crosses 300 meshes, obtain the PORIA ALBA Ultramicro-powder of average grain diameter≤50 μm.
A kind of poria alba powder preparation method of the anti-Sai nti-freckle Chinese medicine spray film.It is characterized in that, to PORIA ALBA coarse powder
It is pulverized, can be used that cut type pulverizes, push-style pulverizes, mill formula is pulverized and (including ball milling, vibromill, stirred
Mix mill) or air-flow any one of superfine communication techniques, the Ultramicro-powder partial size obtained such as to pulverize be 50 μm or less.Further
It is preferred that planetary ball mill is pulverized.
A kind of anti-Sai nti-freckle Chinese medicine sprays film.It is characterized in that, the modifying agent is selected from pectin, glycerol, propylene glycol
The mixing of middle one or more, the pectin are extraordinary low-ester pectin.
The preparation method of a kind of anti-Sai nti-freckle Chinese medicine spray film, it is characterised in that comprise the following steps that: weighing
Appropriate amount of deionized water is added in PVA1788 and chitosan hydrochloride, is stirred under 40 DEG C of water-baths to being completely dissolved；Then described in being added
Rhizoma Kaempferiae extract and PORIA ALBA Ultramicro-powder, add modifying agent, continue stirring and are allowed to dissolution completely；Dehydrated alcohol is added, is mixed
It is settled to 100ml with deionized water after even, is stirred evenly, colourless to yellowish transparent spray film liquid is obtained, it is filling in suitable spray bottle
?.
Present invention medicine mainly based on the traditional Chinese medicine can reduce the irritation to skin and the allergic reaction being likely to occur and poison is secondary makees
With.Wherein kaempferia galanga is the rhizome of Zingiber kaempferia galanga platymiscium kaempferia galanga, light green or green white, fragrant odour.Except as Chinese medicine for invigorating stomach
Except use, also there is spot-eliminating beauty treatment effect.Nti-freckle side is recorded in clear bright volume of Li Wen " celestial being picks up collection ", using kaempferia galanga as main ingredient,
Effect " does not all have " with its spot to 30 days；Modern study is it has also been found that kaempferia galanga has freckle, butterfly macules, cyasma etc. significantly disappears
It removes, desalination effect；In addition kaempferia galanga makees the sun-proof milk of sun-screening agent preparation there are also anti-Sai effect well based on Rhizoma Kaempferiae extract
Liquid, spf value can be and non-stimulated to skin between 6~30.PORIA ALBA is that medicinal material Poria cocos block cuts the white portion after poria cocos
Point, sweet in flavor, light, mild-natured, energy dispelling speckles and whitening face, moist skin, ancient doctor think that Poria cocos can dissolve all blackspot scars, " book on Chinese herbal medicine
Product converge essence will " say: " and PORIA ALBA is end, close honey and, face sore and the black blister of puerpera such as sparrow ovum are treated in surface application ".Since PORIA ALBA is few
PORIA ALBA is carried out ultramicro crushing treatment by the research report of anti-Sai effect, the present invention, and main purpose is the ratio by increasing medicinal powder
Surface area enhances its effect for covering, protecting skin and reflecting sunlight, assigns its anti-Sai function by physical method；In addition
Be conducive to ingredient dissolution, enhance effect of dispelling spots.Therefore, the present invention selects two medicines to share, and passes through the phase on physics and chemical functional
It is auxiliary to coordinate, gather altogether anti-Sai freckle removing and whitening the effect of.
Compared with the prior art, beneficial effects of the present invention are as follows: the present invention is colourless to yellowish transparency liquid, with mist
Shape sprays, and drying forms colourless transparent film rapidly on the skin, easy to use；Using hydrophilic matrix as filmogen, has and protect
The characteristics of wet, good permeability；Preparation method is simple, easy to operate, at low cost, is suitable for industrialized production.
One, a kind of safety evaluatio of anti-Sai nti-freckle Chinese medicine spray film
1. acute toxicity test
Referring to chemicals acute toxicity test technological guidance's principle, healthy SD rat 32 are taken, is randomly divided into 4 groups, i.e.,
Intact skin administration group, damaged skin administration group, intact skin bare substrate group and damaged skin bare substrate group.Before administration
For 24 hours, more solito loses hair or feathers, damaged skin group sand paper abraded skin.Successive administration 7d observes the daily behavior performance of rat
And death condition.
Medicine film does not influence intact skin group as the result is shown, also has no and significantly affects to damaged skin group, damaged skin
Group rat starts to form a scab on day 3, and administration is almost recovered on the 7th day；The crawler behavior of four groups of rats is normal within the observation period, medicine film
Do not have an impact to its coat gloss, diet, excrement and weight etc., does not also occur rats death phenomenon.Show anti-Sai nti-freckle
Chinese medicine sprays film external application and does not generate acute toxic reaction to rat.
2. skin irritation, sensitivity test
Referring to Chemical induced irritation, anaphylaxis and hemolytic investigative technique guideline, healthy SD rat 16 are chosen,
It is randomly divided into intact skin group and damaged skin group.Using the conventional coat for taking off rat back backbone two sides.Respectively same
Dosing film and bare substrate film are applied at rat depilation.Remove film after coating 6h, after striping for 24 hours, 48h and 72h naked eyes see
Situations such as examining coating whether there is or not erythema and oedema at position.
The results show that each group rat after medication 24,48,72h do not occur erythema or oedema phenomenon, anti-Sai nti-freckle
It is nonirritant to normal skin and damaged skin that Chinese medicine sprays film, also to cause allergic reaction.
Two, anti-Sai nti-freckle Chinese medicine spray film quality evaluation
1.pH value
With reference to the guideline in " Chinese Pharmacopoeia " 2015 editions the 4th, according to pH value measuring method, measures and prepared spray film medicine
The pH value of liquid.
Evaluation results are shown in Table 1 by medicine film pH.Three batches of spray film mean ph values are between 4.64~4.68, human skin surface's pH value
Between 4.5~6.5, which will not generate obvious stimulation to human skin within the scope of normal skin pH.
The pH value of 1 three batches, table anti-Sai nti-freckle Chinese medicine spray films
2. moisture retention
A kind of anti-Sai nti-freckle Chinese medicine spray film liquid is uniformly applied on glass slide, and is formed a film in 37 DEG C of drying, at
Film is cut to the square for becoming side length 25mm after film, film is dried in 45 DEG C of baking oven to constant weight together with glass slide, will be carried
Slide and film, which are put in, is equipped with saturation K2CO3It in the closed container of solution, stands overnight at room temperature, takes out film and glass slide afterwards for 24 hours,
Surface moisture is blotted with filter paper, is weighed.Film and glass slide are put into the closed container for being equipped with anhydrous calcium chloride again, for 24 hours after
It takes the film out, weighs.It dries finally, glass slide and film are placed in 45 DEG C of baking ovens to constant weight, takes out weighing.It is measured in parallel 6 groups
Moisture retention ω is calculated as follows in data:
ω=(M2-M3)/(M1-M3) × 100%
In formula, ω: film moisture retention, %；M1: the gross mass of moisture absorption caudacoria and glass slide for 24 hours, g；M2: dry caudacoria for 24 hours and load glass
The gross mass of piece, g；M3: the gross mass of constant weight caudacoria and glass slide, g.
3. gas permeability
Two weighing bottles (25mm × 25mm) are taken, 2g anhydrous calcium chloride is separately added into.It will be in a kind of anti-Sai nti-freckle
Medicine spray film is cut to be suitable for size, seals one of weighing bottle with film, weighs sealer group medicine film, weighing bottle and anhydrous calcium chloride
Total weight and control group weighing bottle and anhydrous calcium chloride total weight；Two weighing bottles are put into be equipped with saturation NaCl it is molten
It in the closed container of liquid, places take out afterwards for 24 hours at room temperature, claim two groups of weight respectively.6 groups of effective data are measured in parallel, are pressed
Formula calculates gas permeability
In formula,Gas permeability, %；M1: sealer group weighing bottle, medicine film and calcium chloride gross mass, g；M2: control group weighing bottle and chlorine
Change calcium gross mass, g；M3: ventilative sealer group weighing bottle rear for 24 hours, medicine film and calcium chloride gross mass, g；M4: ventilative control group rear for 24 hours
Weighing bottle and calcium chloride gross mass, g.
Medicine film moisture retention and gas permeability evaluation result are shown in Table 2.The moisture retention of film is 34.94%, gas permeability 96.40%,
Show that the film for skin surface, can keep skin wet, and will not influence the normal ventilated of skin pore.
The anti-Sai nti-freckle Chinese medicine spray-filming agent moisture retention of table 2, ventilation characteristic measuring result
4. film formation time
Spray film is sprayed on healthy human body skin at room temperature, can be considered film forming when film is tack-free.
The results are shown in Table 3, which is sprayed on skin, waits 3~5min that can form a film, will not be infected with clothing, Bu Huiying
Ring daily normal activity.
The film formation time of the anti-Sai nti-freckle Chinese medicine spray-filming agent of table 3
Detailed description of the invention: nothing
Specific embodiment:
Below with reference to specific embodiment, the further detailed description present invention.It should be understood that these embodiments are intended merely to
It illustrates the present invention, rather than limits the scope of the invention in any way.Term as used in the present invention, unless there are another
External declaration generally has the normally understood meaning of those of ordinary skill in the art.It is any to meet the claims or specification
Description, meet with principles disclosed herein and novelty, the method for inventive features, technique, product, each fall within of the invention
Within protection scope.
Embodiment 1:
A kind of anti-Sai nti-freckle Chinese medicine spray film, is made of the material composition of following quality percent by volume:
Rhizoma Kaempferiae extract: 0.8%
PORIA ALBA Ultramicro-powder: 0.2%
Chitosan hydrochloride: 0.35%
PVA1788:1.5%
Glycerol (modifying agent): 4.0%
Dehydrated alcohol: 60%
Deionized water: surplus
The Rhizoma Kaempferiae extract is the preparation method is as follows: take appropriate kaempferia galanga medicinal material, according to the ratio addition 90% of 20:1
Ethyl alcohol, at room temperature impregnate 12 hours, filtering, filtrate be concentrated to dryness to get.
The preparation method of a kind of anti-Sai nti-freckle Chinese medicine spray film, it is characterised in that comprise the following steps that: weighing
Appropriate amount of deionized water is added in PVA1788 and chitosan hydrochloride, is stirred under 40 DEG C of water bath conditions to being completely dissolved；Then plus
Enter the Rhizoma Kaempferiae extract and PORIA ALBA Ultramicro-powder, add modifying agent, continues stirring and be allowed to dissolution completely；Add anhydrous second
Alcohol is settled to 100ml with deionized water after mixing, stirs evenly, and obtains colourless to yellowish transparent spray film liquid, filling in suitable spray
In bottle.
Embodiment 2:
A kind of anti-Sai nti-freckle Chinese medicine spray film, is made of the material composition of following quality percent by volume:
Rhizoma Kaempferiae extract: 0.7%
PORIA ALBA Ultramicro-powder: 0.3%
Chitosan hydrochloride: 0.4%
PVA1788:1.75%
Glycerol (modifying agent): 4.0%
Dehydrated alcohol: 50%
Deionized water: surplus
The Rhizoma Kaempferiae extract is the preparation method is as follows: take appropriate kaempferia galanga medicinal material, according to the ratio addition 95% of 10:1
Ethyl alcohol, at room temperature impregnate 12 hours, filtering, filtrate be concentrated to dryness to get.
The preparation method of a kind of anti-Sai nti-freckle Chinese medicine spray film, it is characterised in that comprise the following steps that: weighing
Appropriate amount of deionized water is added in PVA1788 and chitosan hydrochloride, is stirred under 40 DEG C of water bath conditions to being completely dissolved；Then plus
Enter the Rhizoma Kaempferiae extract and PORIA ALBA Ultramicro-powder, add modifying agent, continues stirring and be allowed to dissolution completely；Add anhydrous second
Alcohol is settled to 100ml with deionized water after mixing, stirs evenly, and obtains colourless to yellowish transparent spray film liquid, filling in suitable spray
In bottle.
Embodiment 3:
A kind of anti-Sai nti-freckle Chinese medicine spray film, is made of the material composition of following quality percent by volume:
Rhizoma Kaempferiae extract: 0.4%
PORIA ALBA Ultramicro-powder: 0.6%
Chitosan hydrochloride: 0.4%
PVA1788:1.75%
Low-ester pectin (modifying agent): 7.0%
Dehydrated alcohol: 30%
Deionized water: surplus
The Rhizoma Kaempferiae extract is the preparation method is as follows: take appropriate kaempferia galanga medicinal material, according to the anhydrous second of ratio addition of 5:1
Alcohol, at room temperature impregnate 12 hours, filtering, filtrate be concentrated to dryness to get.
The preparation method of a kind of anti-Sai nti-freckle Chinese medicine spray film, it is characterised in that comprise the following steps that: weighing
Appropriate amount of deionized water is added in PVA1788 and chitosan hydrochloride, is stirred under 40 DEG C of water bath conditions to being completely dissolved；Then plus
Enter the Rhizoma Kaempferiae extract and PORIA ALBA Ultramicro-powder, add modifying agent, continues stirring and be allowed to dissolution completely；Add anhydrous second
Alcohol is settled to 100ml with deionized water after mixing, stirs evenly, and obtains colourless to yellowish transparent spray film liquid, filling in suitable spray
In bottle.
Embodiment 4:
A kind of anti-Sai nti-freckle Chinese medicine spray film, is made of the material composition of following quality percent by volume:
Rhizoma Kaempferiae extract: 0.5%
PORIA ALBA Ultramicro-powder: 0.5%
Chitosan hydrochloride: 0.4%
PVA1788:1.8%
Propylene glycol (modifying agent): 1.0%
Dehydrated alcohol: 50%
Deionized water: surplus
The Rhizoma Kaempferiae extract is the preparation method is as follows: take appropriate kaempferia galanga medicinal material, according to the ratio addition 95% of 15:1
Ethyl alcohol, at room temperature impregnate 12 hours, filtering, filtrate be concentrated to dryness to get.
The preparation method of a kind of anti-Sai nti-freckle Chinese medicine spray film, it is characterised in that comprise the following steps that: weighing
Appropriate amount of deionized water is added in PVA1788 and chitosan hydrochloride, is stirred under 40 DEG C of water bath conditions to being completely dissolved；Then plus
Enter the Rhizoma Kaempferiae extract and PORIA ALBA Ultramicro-powder, add modifying agent, continues stirring and be allowed to dissolution completely；Add anhydrous second
Alcohol is settled to 100ml with deionized water after mixing, stirs evenly, and obtains colourless to yellowish transparent spray film liquid, filling in suitable spray
In bottle.
Embodiment 5:
A kind of anti-Sai nti-freckle Chinese medicine spray film, is made of the material composition of following quality percent by volume:
Rhizoma Kaempferiae extract: 0.8%
PORIA ALBA Ultramicro-powder: 0.2%
Chitosan hydrochloride: 0.25%
PVA1788:1.25%
Glycerol (modifying agent): 5.75%
Dehydrated alcohol: 45%
Deionized water: surplus
The Rhizoma Kaempferiae extract is the preparation method is as follows: take appropriate kaempferia galanga medicinal material, according to the ratio addition 95% of 15:1
Ethyl alcohol, at room temperature impregnate 12 hours, filtering, filtrate be concentrated to dryness to get.
The preparation method of a kind of anti-Sai nti-freckle Chinese medicine spray film, it is characterised in that comprise the following steps that: weighing
Appropriate amount of deionized water is added in PVA1788 and chitosan hydrochloride, is stirred under 40 DEG C of water bath conditions to being completely dissolved；Then plus
Enter the Rhizoma Kaempferiae extract and PORIA ALBA Ultramicro-powder, add modifying agent, continues stirring and be allowed to dissolution completely；Add anhydrous second
Alcohol is settled to 100ml with deionized water after mixing, stirs evenly, and obtains colourless to yellowish transparent spray film liquid, filling in suitable spray
In bottle.
Claims (7)
1. a kind of anti-Sai nti-freckle Chinese medicine sprays film, it is characterised in that be made of the material composition of following quality percent by volume:
Rhizoma Kaempferiae extract: 0.1~2.0%
Poria alba powder: 0.1~1.0%
Chitosan hydrochloride: 0.1~5.0%
PVA1788:0.1~5.0%
Modifying agent: 1.0~10.0%
Dehydrated alcohol: 20~70%
Deionized water: surplus.
2. a kind of anti-Sai nti-freckle Chinese medicine according to claim 1 sprays film.It is characterized in that, the Rhizoma Kaempferiae extract is ethyl alcohol
Extract.Preparation method is as follows: kaempferia galamga medicinal material is taken in right amount, and ethyl alcohol is added according to the ratio of 5:1~20:1, impregnates at room temperature
12 hours, filtering discarded filter residue, filtrate be concentrated to dryness to get.
3. a kind of Rhizoma Kaempferiae extract preparation method of anti-Sai nti-freckle Chinese medicine spray film according to claim 2.It is characterized in that
Ethyl alcohol used is medical grade ethyl alcohol, and concentration is 90~100%, and wherein concentration of alcohol is preferably 95%.
4. a kind of anti-Sai nti-freckle Chinese medicine according to claim 1 sprays film.It is characterized in that, the poria alba powder is ultra micro
Powder.Preparation method is as follows: PORIA ALBA medicinal material being cleaned, is dried.First PORIA ALBA is tentatively crushed, is sieved with 100 mesh sieve, is obtained
PORIA ALBA coarse powder, then PORIA ALBA coarse powder is pulverized, 300 meshes are crossed, the PORIA ALBA for obtaining average grain diameter≤50 μm is super
Micro mist.
5. a kind of poria alba powder preparation method of anti-Sai nti-freckle Chinese medicine spray film according to claim 4.It is characterized in that, right
PORIA ALBA coarse powder is pulverized, can be used cut type pulverize, push-style pulverize, mill formula pulverize (including ball milling,
Vibromill, Ball-stirring mill) or air-flow any one of the superfine communication techniques such as pulverize, Ultramicro-powder partial size obtained be 50 μm with
Under.Further preferred planetary ball mill is pulverized.
6. a kind of anti-Sai nti-freckle Chinese medicine according to claim 1 sprays film.It is characterized in that, the modifying agent be selected from pectin,
One or more of mixing in glycerol, propylene glycol, the pectin are extraordinary low-ester pectin.
7. a kind of preparation method of anti-Sai nti-freckle Chinese medicine spray film as described in claim 1, it is characterised in that walked including following technique
It is rapid: to weigh PVA1788 and appropriate chitosan hydrochloride, appropriate amount of deionized water is added, stirred under 40 DEG C of water-baths to being completely dissolved；
Then prepared Rhizoma Kaempferiae extract and appropriate poria alba powder is added, adds appropriate modifier, continues stirring and is allowed to dissolve
Entirely；It is appropriate to add dehydrated alcohol, is settled to 100ml with deionized water after mixing, stirs evenly, obtains colourless to yellowish transparent
Film liquid is sprayed, it is filling in suitable spray bottle.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810926819.9A CN109010086A (en) | 2018-08-15 | 2018-08-15 | A kind of anti-Sai nti-freckle Chinese medicine spray film and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115594892A (en) * | 2022-10-11 | 2023-01-13 | 重庆工商大学（Cn） | Kaempferia galangal antibacterial component composite membrane and preparation method thereof |
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| US20070264204A1 (en) * | 2006-05-11 | 2007-11-15 | Air Products And Chemicals, Inc. | Personal care compositions containing functionalized polymers |
| CN108261447A (en) * | 2018-02-09 | 2018-07-10 | 青岛科技大学 | A kind of traumatic surface spray-filming agent of the Ultramicro-powder containing rheum officinale and preparation method thereof |
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Application publication date: 20181218 |