CN107080768A - A kind of dual effect type gel bring down a fever patch and preparation method thereof - Google Patents
A kind of dual effect type gel bring down a fever patch and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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Abstract
The present invention relates to medical products field, disclose a kind of dual effect type gel bring down a fever patch and preparation method thereof.The patch of bringing down a fever is made by the raw material of following parts by weight：90 110 parts of seaweed extracted liquor, 250 500 parts of crosslinker solution, 37 parts of patchouli oil, 37 parts of peppermint oil, 24 parts of Honegsukle flower P.E, 24 parts of ammonium chloride, 0.5 1.5 parts of cellulose gum, 13 parts of sodium carboxymethylcellulose, 40 60 parts of alcohol, 24 parts of sodium carbonate, 36 parts of citric acid.The composition for pasting and bringing down a fever and being brought down a fever with medicine containing physics simultaneously of bringing down a fever of the present invention, can quickly bring down a fever.And the patch of bringing down a fever of the present invention has preferably gas permeability, is conducive to cutaneous respiration and radiating, comfort is strong.
Description
Technical field
The present invention relates to medical products field, more particularly to a kind of dual effect type gel is brought down a fever patch and preparation method thereof.
Background technology
In fever, typically there are injection medicine, endo-medicine and three kinds of modes of external used medicine available, comparatively,
Inject medicine and endo-medicine is smaller very fast, but for children or infant, above two mode not enough facilitates.One
As can all implement the mode of external used medicine.For the external used medicine brought down a fever, have on the market piece of bringing down a fever, bring down a fever patch etc. product.Have
It is, using pad pasting as matrix, to have plenty of using hydrogel and be used as matrix.Piece, the patch of bringing down a fever of bringing down a fever can play heat-clearing to patient, bring down a fever
Effect.
Patent CN201610128984.0 discloses a kind of cold compress gel, and it is matched somebody with somebody by following component raw material according to parts by weight
Than mixing, the parts by weight of each component raw material are as follows：1-500 parts of guar gum, 1-500 parts of xanthans, propane diols 2-
1000 parts, 2-1000 parts of glycerine, 0.1-100 parts of ethyl-para-hydroxybenzoate, 0-1500 parts of purified water.The invention is using external
The mode of smearing, by being applied to body meridian point, active ingredient is go the rounds with channels and collaterals, and cold compress cooling-down effect significantly, and does not enter
Enter internal digestive system, be that bringing down a fever for a safety and environmental friendliness is brought down a fever and prevented heatstroke and lower the temperature without any injury or toxic side effect
Product.
Although above-mentioned cold compress gel has cold compress cooling effect, it is simply brought down a fever for physically, not pastille
Thing, it is less efficient.In addition, gel is made by matrix of various glue classes for the cold compress gel, the gel gas permeability is poor, will after laying
Skin is thoroughly isolated with air, is unfavorable for the breathing and radiating of skin, influences the secreting function of cell, and comfort is poor.
The content of the invention
In order to solve the above-mentioned technical problem, the invention provides a kind of dual effect type gel bring down a fever patch and preparation method thereof.This
The composition for pasting and bringing down a fever and being brought down a fever with medicine containing physics simultaneously of bringing down a fever of invention, can quickly bring down a fever.And the patch of bringing down a fever of the present invention
With preferably gas permeability, be conducive to cutaneous respiration and radiating, comfort is strong.
The present invention concrete technical scheme be：A kind of dual effect type gel is brought down a fever patch, is made by the raw material of following parts by weight：
90-110 parts of seaweed extracted liquor, 250-500 parts of crosslinker solution, 3-7 parts of patchouli oil, 3-7 parts of peppermint oil, honeysuckle
2-4 parts of extract, 2-4 parts of ammonium chloride, 0.5-1.5 parts of cellulose gum, 1-3 parts of sodium carboxymethylcellulose, 40-60 parts of alcohol, carbon
Sour sodium 2-4 parts, 3-6 parts of citric acid.
The patch of bringing down a fever of the present invention be crosslinked using seaweed extracted liquor after gel as matrix, contain alginic acid in seaweed extracted liquor
Sodium, algal polysaccharides isoreactivity material, transparent mucus shape, the effects such as with water conservation, wetting, antibacterial, after being laid on skin, parent
Skin is good, and skin will not be made to produce allergy.
The present invention is added with the medicines such as patchouli oil, peppermint oil and Honegsukle flower P.E in patch of bringing down a fever, wherein, Pogostemon cablin
Oil have inducing diaphoresis dampness elimination, qi-regulating and it is middle the effect of, can driving away summer heat it is antipyretic, it is adaptable to headache dusk weight, the vexed disease person of chest diaphragm ruffian.Peppermint
The effect of oil has heat-clearing, refreshed oneself, is conducive to bringing down a fever.Honegsukle flower P.E has effects that radiating removing toxic substances, anti-inflammation.Except upper
State medicine to bring down a fever outside composition, the present invention also contains to bring down a fever composition-ammonium chloride, chlorination with the physics after dissolving with heat absorption function
Ammonium, which is substantially soluble in after water, to absorb heat, and can play cooling effect.To sum up, the present invention simultaneously there is medicine to bring down a fever with physics and move back
Burn till point, bring down a fever fast under synergy.
In addition, sodium carboxymethylcellulose has thickening and peptizaiton, it is possible to increase the stickiness of gel and in gel
Other components play dispersion effect.Cellulose gum plays viscosifying action, it is possible to increase the cohesive of gel and skin, and it is in addition
Natural materials, it is non-stimulated to skin.
Preferably, the crosslinker solution is 3-5wt% calcium chloride solution.
Preferably, the ammonium chloride passes through pregelatinized starch embedding treatment.
Absorbed heat during chloride leach, so if just running into substantial amounts of water in preparation process, be easy to lose effect.For this
The present invention has pregelatinized starch in ammonium chloride Surface coating, plays buffer action, can prevent that ammonium chloride is big in preparation process
Amount is dissolved in water and absorbed heat in advance.
Preferably, the moisture content of the seaweed extracted liquor is 25-35wt%.
Preferably, the patchouli oil and/or peppermint oil are handled before addition through overload：Take patchouli oil
And/or peppermint oil；Then the gas phase hydrophobic silica of 0.3-0.5 times of its quality is added into patchouli oil and/or peppermint oil
Powder, stirs, and obtains the patchouli oil and/or peppermint oil of load processing.
The patch although gel that patchouli oil and peppermint oil for bringing down a fever with preferable effect, are due to the present invention is brought down a fever
For hydrophilic matrix, and patchouli oil and peppermint oil are oily matter, and its compatibility with whole matrix is poor.It is prepared by patch of bringing down a fever
After finishing, during long-time is preserved or at relatively high temperatures, patchouli oil and peppermint oil be easily precipitated and and matrix
Separation, this can have a strong impact on the effect for patch of bringing down a fever.Therefore, patchouli oil and peppermint oil are carried on the hydrophobic dioxy of gas phase by the present invention
SiClx powder, gas phase hydrophobic titanium dioxide silica flour has the specific surface area of superelevation, and with hydrophobicity, can largely load Pogostemon cablin
Oil and peppermint oil, so that patchouli oil and peppermint oil are provided with a stable carrier, are not easily runed off.And for gas phase hydrophobic two
Silica powder can have preferable dispersion effect from the scattered then dependence sodium carboxymethylcellulose in gel.
Preferably, the preparation method of the gas phase hydrophobic titanium dioxide silica flour is：Tetraethyl orthosilicate is used
80wt% alcoholic solution dilutes 40-50 times, and after being well mixed, acetum is added dropwise under 50-60 DEG C of water-bath, stirring condition,
Make to form colloidal sol in solution, when there is no during the formation of new colloidal sol, stop reaction；By colloidal sol aging 1-2 days at room temperature, then
The former solvent in colloidal sol is changed with organic solvent, after supercritical fluid drying removes organic solvent, pulverization process, gas is obtained
Aerosil powder；Under conditions of nitrogen protection, water flowing, 350-550 DEG C, with Trichloromethyl silane to aerosil
Powder is modified processing 2-4h, and gas phase hydrophobic titanium dioxide silica flour is made.
For the characteristic of patchouli oil and peppermint oil, the present invention is using gas phase hydrophobic silica made from the above method
Powder, with preferable porosity, can preferably be loaded to patchouli oil and peppermint oil, and load fastness is high, can prevent the wide leaves of pulse plants
Sesame oil and peppermint oil are lost in.
Preferably, the consumption of the Trichloromethyl silane is the 8-12% of hydrophobic silica silty amount, institute
The particle diameter for stating gas phase hydrophobic titanium dioxide silica flour is 50-200 microns.
A kind of dual effect type gel is brought down a fever the preparation method of patch, and step is as follows：
(a) patchouli oil, peppermint oil, Honegsukle flower P.E, sodium carboxymethylcellulose are added to seaweed extracted liquor successively
In, stir, obtain sticky mixing mucus.
(b) under conditions of stirring at low speed, 1-5 DEG C, sodium carbonate and citric acid are successively added into mixing mucus, until stirring
Mix uniform.
(c) mixing mucus is stirred vigorously and heating treatment simultaneously, sodium carbonate and citric acid is fully contacted concurrently
The alveolate mucus of parcel is made after raw reaction, fully reaction.
(d) mucus of step (c) is transferred in pressure reduction vessel, alcohol is added under stirring at low speed, after stirring, taken
Go out, drain unnecessary alcohol and water；Then ammonium chloride and cellulose gum are added again, and stirring at low speed is uniform.
(e) mucus that step (d) is obtained is added in crosslinker solution, carries out cross-linking reaction, until after reaction terminates, mistake
Filter, the jel product shaped is made dual effect type gel and brought down a fever patch after cutting.
Although the gel-type vehicle after seaweed extracted liquor crosslinking has preferable moisture retention, its gas permeability still needs to be carried
It is high.In patch preparation process of bringing down a fever, first patchouli oil, peppermint oil, Honegsukle flower P.E, sodium carboxymethylcellulose are added successively
It is well mixed into seaweed extracted liquor, sodium carbonate and citric acid is then added, in the process, in order to prevent sodium carbonate and lemon
Sour antedating response, it is necessary to be that under low stir speed (S.S.), cryogenic conditions, addition is stirred vigorously and heated up again after finishing, and makes carbon
Sour sodium and citric acid are fully contacted and reacted, and a large amount of bubbles are formed in matrix, and the bubble is wrapped in matrix, is acutely stirred
The meaning mixed is while can also be mixed into extraneous air in matrix, and be stirred vigorously and can divide the bubble of large volume
Split for the micro-bubble of multiple small sizes.Then mucus is transferred in pressure reduction vessel, under subnormal ambient, the gas in bubble
Because bubble inside and outside differential pressure is escaped, alcohol is added under stirring at low speed, solubility very little of the seaweed extracted liquor in alcohol,
Therefore in whipping process alcohol can rapid osmotic enter bubble replace gas.Then under stirring at low speed add ammonium chloride and
Cellulose gum, now content is less for matrix reclaimed water, and matrix is in very sticky shape, and the solubility of ammonium chloride is not high.And incite somebody to action
The reason for cellulose gum is added at this moment be：If adding cellulose gum in advance, it will enter the viscosity of matrix is significantly greatly increased, be unfavorable for
Scattered and reaction the progress of material.Finally mucus is added in crosslinker solution and carries out cross-linking reaction, qualitatively gel is obtained
Product.It is made and brings down a fever after patch, closed on its surface with pad pasting, pad pasting is just torn when using, will brings down a fever after sticking and setting, due to gel
Matrix and air bump contact, volatilize rapidly after alcohol heat absorption, refrigerant sense are carried out to skin tape, and it has Disinfection Effect.And
The micro-bubble originally filled after alcohol volatilization in matrix by alcohol is released, and forms substantial amounts of capillary channel, therefore patch of bringing down a fever
Gas permeability be improved, be conducive to cutaneous respiration and radiating.Ammonium chloride is run into after the higher skin of temperature simultaneously, and it is water-soluble
It is improved, therefore a large amount of dissolving and heat absorbings, be conducive to bringing down a fever.
Preferably, the speed of stirring at low speed is 100-200r/min in step (b), is stirred vigorously in step (c)
Speed be 800-1200r/min, the speed of stirring at low speed is 40-80r/min in step (d).
Preferably, it is 5-10 DEG C that crosslinker solution temperature in 50-60 DEG C, step (d) is warming up in step (c).
In step (c), with the rise of temperature, sodium carbonate and citric acid gradually react.In step (d), in order to
The a large amount of dissolving and heat absorbings of ammonium chloride are prevented, according to its higher water-soluble better dissolving feature of ammonium chloride temperature, it is necessary to will be crosslinked molten
Hydraulic control system controls the solubility of ammonium chloride in lower temperature.
It is compared with the prior art, the beneficial effects of the invention are as follows：The patch of bringing down a fever of the present invention is brought down a fever and medicine containing physics simultaneously
The composition that thing is brought down a fever, can quickly bring down a fever.And the patch of bringing down a fever of the present invention has preferably gas permeability, be conducive to cutaneous respiration and
Radiating, comfort is strong.
Embodiment
With reference to embodiment, the invention will be further described.
Embodiment 1
A kind of dual effect type gel is brought down a fever patch, is made by the raw material of following parts by weight：
100 parts of seaweed extracted liquor (moisture content 30wt%), 400 parts of 4wt% calcium chloride solution, 5 parts of patchouli oil, peppermint
5 parts of oil, 3 parts of Honegsukle flower P.E, pregelatinized starch 3 parts of ammonium chloride of embedding, 1 part of cellulose gum, 2 parts of sodium carboxymethylcellulose,
50 parts of alcohol, 3 parts of sodium carbonate, 5 parts of citric acid.
Above-mentioned dual effect type gel is brought down a fever the preparation method of patch, and step is as follows：
(a) patchouli oil, peppermint oil, Honegsukle flower P.E, sodium carboxymethylcellulose are added to seaweed extracted liquor successively
In, stir, obtain sticky mixing mucus.
(b) under conditions of stirring at low speed (150r/min), 3 DEG C, sodium carbonate and lemon are successively added into mixing mucus
Acid, until stirring.
(c) (1000r/min) is stirred vigorously simultaneously to mixing mucus and is warming up to 55 DEG C, make sodium carbonate and citric acid
Fully contact and react, the alveolate mucus of parcel is fully made after reaction.
(d) mucus of step (c) is transferred in pressure reduction vessel, alcohol is added under stirring at low speed (60r/min), stirred
After uniform, take out, drain unnecessary alcohol and water；Then ammonium chloride and cellulose gum are added again, and stirring at low speed (60r/min) is
It is even.
(e) mucus that step (d) is obtained is added in 8 DEG C of crosslinker solution, carries out cross-linking reaction, until reaction terminates
Afterwards, filter, the jel product shaped, dual effect type gel is made after cutting and brings down a fever patch.
Embodiment 2
A kind of dual effect type gel is brought down a fever patch, is made by the raw material of following parts by weight：
100 parts of seaweed extracted liquor (moisture content 30wt%), 400 parts of 4wt% calcium chloride solution, 5 parts of patchouli oil, peppermint
5 parts of oil, 3 parts of Honegsukle flower P.E, pregelatinized starch 3 parts of ammonium chloride of embedding, 1 part of cellulose gum, 2 parts of sodium carboxymethylcellulose,
50 parts of alcohol, 3 parts of sodium carbonate, 5 parts of citric acid.
Wherein, the patchouli oil and peppermint oil are handled before addition through overload：Take patchouli oil and peppermint oil；Then
The gas phase hydrophobic titanium dioxide silica flour of 0.4 times of its quality is added into patchouli oil and peppermint oil, is stirred, load processing is obtained
Patchouli oil and peppermint oil.
The preparation method of the gas phase hydrophobic titanium dioxide silica flour is：Tetraethyl orthosilicate is dilute with 80wt% alcoholic solution
45 times are released, after being well mixed, acetum is added dropwise under 550 DEG C of water-baths, stirring conditions, makes to form colloidal sol in solution, when no longer
When having new colloidal sol formation, stop reaction；By colloidal sol aging 1.5 days at room temperature, then changed with organic solvent in colloidal sol
Former solvent, after supercritical fluid drying removes organic solvent, pulverization process, obtains the gas phase two that particle diameter is 50-200 microns
Silica powder；Under conditions of nitrogen protection, water flowing, 450 DEG C, with Trichloromethyl silane (hydrophobic silica silty amount
10%) processing 3h is modified to aerosil powder, gas phase hydrophobic titanium dioxide silica flour is made.
Above-mentioned dual effect type gel is brought down a fever the preparation method of patch, and step is as follows：
(a) patchouli oil, peppermint oil, Honegsukle flower P.E, sodium carboxymethylcellulose are added to seaweed extracted liquor successively
In, stir, obtain sticky mixing mucus.
(b) under conditions of stirring at low speed (150r/min), 3 DEG C, sodium carbonate and lemon are successively added into mixing mucus
Acid, until stirring.
(c) (1000r/min) is stirred vigorously simultaneously to mixing mucus and is warming up to 55 DEG C, make sodium carbonate and citric acid
Fully contact and react, the alveolate mucus of parcel is fully made after reaction.
(d) mucus of step (c) is transferred in pressure reduction vessel, alcohol is added under stirring at low speed (60r/min), stirred
After uniform, take out, drain unnecessary alcohol and water；Then ammonium chloride and cellulose gum are added again, and stirring at low speed (60r/min) is
It is even.
(e) mucus that step (d) is obtained is added in 8 DEG C of crosslinker solution, carries out cross-linking reaction, until reaction terminates
Afterwards, filter, the jel product shaped, dual effect type gel is made after cutting and brings down a fever patch.
Embodiment 3
A kind of dual effect type gel is brought down a fever patch, is made by the raw material of following parts by weight：
90 parts of seaweed extracted liquor (moisture content 25wt%), 250 parts of 5wt% calcium chloride solution, 3 parts of patchouli oil, peppermint
7 parts of oil, 2 parts of Honegsukle flower P.E, pregelatinized starch 4 parts of ammonium chloride of embedding, 0.5 part of cellulose gum, sodium carboxymethylcellulose 3
Part, 40 parts of alcohol, 2 parts of sodium carbonate, 3 parts of citric acid.
Wherein, the patchouli oil and peppermint oil are handled before addition through overload：Take patchouli oil and peppermint oil；Then
The gas phase hydrophobic titanium dioxide silica flour of 0.3 times of its quality is added into patchouli oil and peppermint oil, is stirred, load processing is obtained
Patchouli oil and peppermint oil.
The preparation method of the gas phase hydrophobic titanium dioxide silica flour is：Tetraethyl orthosilicate is dilute with 80wt% alcoholic solution
Release 40 times, be well mixed after, acetum is added dropwise under 50 DEG C of water-baths, stirring conditions, makes to form colloidal sol in solution, when there is no
When new colloidal sol is formed, stop reaction；By colloidal sol aging 1 day at room temperature, then changed with organic solvent former molten in colloidal sol
Agent, after supercritical fluid drying removes organic solvent, pulverization process, obtains the gas phase titanium dioxide that particle diameter is 50-200 microns
Silica flour；Under conditions of nitrogen protection, water flowing, 350 DEG C, with Trichloromethyl silane (the 8% of hydrophobic silica silty amount)
Processing 2h is modified to aerosil powder, gas phase hydrophobic titanium dioxide silica flour is made.
Above-mentioned dual effect type gel is brought down a fever the preparation method of patch, and step is as follows：
(a) patchouli oil, peppermint oil, Honegsukle flower P.E, sodium carboxymethylcellulose are added to seaweed extracted liquor successively
In, stir, obtain sticky mixing mucus.
(b) under conditions of stirring at low speed (100r/min), 1 DEG C, sodium carbonate and lemon are successively added into mixing mucus
Acid, until stirring.
(c) (800r/min) is stirred vigorously simultaneously to mixing mucus and is warming up to 50 DEG C, make sodium carbonate and citric acid
Fully contact and react, the alveolate mucus of parcel is fully made after reaction.
(d) mucus of step (c) is transferred in pressure reduction vessel, alcohol is added under stirring at low speed (40r/min), stirred
After uniform, take out, drain unnecessary alcohol and water；Then ammonium chloride and cellulose gum are added again, and stirring at low speed (40r/min) is
It is even.
(e) mucus that step (d) is obtained is added in 5 DEG C of crosslinker solution, carries out cross-linking reaction, until reaction terminates
Afterwards, filter, the jel product shaped, dual effect type gel is made after cutting and brings down a fever patch.
Embodiment 4
A kind of dual effect type gel is brought down a fever patch, is made by the raw material of following parts by weight：
110 parts of seaweed extracted liquor (moisture content 35wt%), 500 parts of 3wt% calcium chloride solution, 7 parts of patchouli oil, peppermint
3 parts of oil, 4 parts of Honegsukle flower P.E, pregelatinized starch 2 parts of ammonium chloride of embedding, 1.5 parts of cellulose gum, sodium carboxymethylcellulose 1
Part, 60 parts of alcohol, 4 parts of sodium carbonate, 6 parts of citric acid.
Wherein, the patchouli oil and peppermint oil are handled before addition through overload：Take patchouli oil and peppermint oil；Then
The gas phase hydrophobic titanium dioxide silica flour of 0.5 times of its quality is added into patchouli oil and peppermint oil, is stirred, load processing is obtained
Patchouli oil and peppermint oil.
The preparation method of the gas phase hydrophobic titanium dioxide silica flour is：Tetraethyl orthosilicate is dilute with 80wt% alcoholic solution
Release 50 times, be well mixed after, acetum is added dropwise under 60 DEG C of water-baths, stirring conditions, makes to form colloidal sol in solution, when there is no
When new colloidal sol is formed, stop reaction；By colloidal sol aging 2 days at room temperature, then changed with organic solvent former molten in colloidal sol
Agent, after supercritical fluid drying removes organic solvent, pulverization process, obtains the gas phase titanium dioxide that particle diameter is 50-200 microns
Silica flour；Under conditions of nitrogen protection, water flowing, 550 DEG C, with Trichloromethyl silane (the 12% of hydrophobic silica silty amount)
Processing 4h is modified to aerosil powder, gas phase hydrophobic titanium dioxide silica flour is made.
Above-mentioned dual effect type gel is brought down a fever the preparation method of patch, and step is as follows：
(a) patchouli oil, peppermint oil, Honegsukle flower P.E, sodium carboxymethylcellulose are added to seaweed extracted liquor successively
In, stir, obtain sticky mixing mucus.
(b) under conditions of stirring at low speed (200r/min), 5 DEG C, sodium carbonate and lemon are successively added into mixing mucus
Acid, until stirring.
(c) (1200r/min) is stirred vigorously simultaneously to mixing mucus and is warming up to 60 DEG C, make sodium carbonate and citric acid
Fully contact and react, the alveolate mucus of parcel is fully made after reaction.
(d) mucus of step (c) is transferred in pressure reduction vessel, alcohol is added under stirring at low speed (80r/min), stirred
After uniform, take out, drain unnecessary alcohol and water；Then ammonium chloride and cellulose gum are added again, and stirring at low speed (80r/min) is
It is even.
(e) mucus that step (d) is obtained is added in 10 DEG C of crosslinker solution, carries out cross-linking reaction, until reaction knot
Shu Hou, filtering, the jel product shaped is made dual effect type gel and brought down a fever patch after cutting.
By embodiment 1 and bring down a fever patch and the patch of bringing down a fever of common hydrogel matrix (comparative example) on the market of embodiment 2
Contrasted.
The sensory evaluation of each 10 fever cases (men and women half and half, and body temperature is at 38 DEG C or so) of collection, is counted as follows：
To the exchange premium row storage stability test of bringing down a fever of Examples 1 and 2, the patch of bringing down a fever of Examples 1 and 2 is entered at normal temperatures
Row is preserved, and observation, which is brought down a fever, pastes outward appearance and carry out recording observation situation.
| Group number | 1 month | 6 months | 12 months | 24 months |
| Embodiment 1 | Without difference | Without difference | There is a little oil liquation to go out | There are a large amount of fluid to separate out |
| Embodiment 2 | Without difference | Without difference | Without difference | Without difference |
Raw materials used in the present invention, equipment, is the conventional raw material, equipment of this area unless otherwise noted；In the present invention
Method therefor, is the conventional method of this area unless otherwise noted.
It is described above, only it is presently preferred embodiments of the present invention, not the present invention is imposed any restrictions, it is every according to the present invention
Any simple modification, change and equivalent transformation that technical spirit is made to above example, still fall within the technology of the present invention side
The protection domain of case.
Claims (8)
- The patch 1. a kind of dual effect type gel is brought down a fever, it is characterised in that：It is made by the raw material of following parts by weight：90-110 parts of seaweed extracted liquor,250-500 parts of crosslinker solution,3-7 parts of patchouli oil,3-7 parts of peppermint oil,2-4 parts of Honegsukle flower P.E,2-4 parts of ammonium chloride,0.5-1.5 parts of cellulose gum,1-3 parts of sodium carboxymethylcellulose,40-60 parts of alcohol,2-4 parts of sodium carbonate,3-6 parts of citric acid.
- The patch 2. a kind of dual effect type gel as claimed in claim 1 is brought down a fever, it is characterised in that：The crosslinker solution is 3-5wt% Calcium chloride solution.
- The patch 3. a kind of dual effect type gel as claimed in claim 1 is brought down a fever, it is characterised in that：The ammonium chloride forms sediment by pregelatinated Powder embedding treatment.
- The patch 4. a kind of dual effect type gel as claimed in claim 2 is brought down a fever, it is characterised in that：The moisture content of the seaweed extracted liquor For 25-35wt%.
- The patch 5. a kind of dual effect type gel as claimed in claim 1 is brought down a fever, it is characterised in that：The patchouli oil and/or peppermint Oil is handled before addition through overload：Take patchouli oil and/or peppermint oil；Then added into patchouli oil and/or peppermint oil The gas phase hydrophobic titanium dioxide silica flour of 0.3-0.5 times of its quality, stirs, and obtains patchouli oil and/or the peppermint of load processing Oil.
- The preparation method of patch 6. a kind of dual effect type gel as described in claim 1-5 is any is brought down a fever, it is characterised in that step is such as Under：(a) patchouli oil, peppermint oil, Honegsukle flower P.E, sodium carboxymethylcellulose are added in seaweed extracted liquor successively, stirred Mix uniform, obtain sticky mixing mucus；(b) under conditions of stirring at low speed, 1-5 DEG C, sodium carbonate and citric acid are successively added into mixing mucus, until stirring is equal It is even；(c) mixing mucus is stirred vigorously and heating treatment simultaneously, sodium carbonate and citric acid is fully contacted and is occurred anti- Should, the alveolate mucus of parcel is fully made after reaction；(d) mucus of step (c) is transferred in pressure reduction vessel, alcohol is added under stirring at low speed, after stirring, taken out, Drain unnecessary alcohol and water；Then ammonium chloride and cellulose gum are added again, and stirring at low speed is uniform；(e) mucus that step (d) is obtained is added in crosslinker solution, carries out cross-linking reaction, until after reaction terminates, filtering, The jel product shaped, is made dual effect type gel and brings down a fever patch after cutting.
- The preparation method of patch 7. a kind of dual effect type gel as claimed in claim 6 is brought down a fever, it is characterised in that：It is low in step (b) The speed of speed stirring is 100-200r/min, and the speed being stirred vigorously in step (c) is low in 800-1200r/min, step (d) The speed of speed stirring is 40-80r/min.
- The preparation method of patch 8. a kind of dual effect type gel as claimed in claim 6 is brought down a fever, it is characterised in that：Risen in step (c) Temperature is to 50-60 DEG C, and crosslinker solution temperature is 5-10 DEG C in step (d).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710287048.9A CN107080768A (en) | 2017-04-27 | 2017-04-27 | A kind of dual effect type gel bring down a fever patch and preparation method thereof |
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| CN201710287048.9A CN107080768A (en) | 2017-04-27 | 2017-04-27 | A kind of dual effect type gel bring down a fever patch and preparation method thereof |
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| CN107080768A true CN107080768A (en) | 2017-08-22 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109820839A (en) * | 2019-04-04 | 2019-05-31 | 广东泰宝医疗科技股份有限公司 | It is a kind of medical defervescence plaster used and preparation method thereof |
| CN114984083A (en) * | 2022-07-11 | 2022-09-02 | 陕西康惠制药股份有限公司 | A Chinese medicinal composition for treating upper respiratory infection, and its preparation method |
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| JP2007001926A (en) * | 2005-06-24 | 2007-01-11 | Ltt Bio-Pharma Co Ltd | Steroidal preparation for inhalation/nebulization |
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| CN114984083A (en) * | 2022-07-11 | 2022-09-02 | 陕西康惠制药股份有限公司 | A Chinese medicinal composition for treating upper respiratory infection, and its preparation method |
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