CN106975096A - A kind of unformed dressing of the scald wound containing snake oil and preparation method thereof - Google Patents
A kind of unformed dressing of the scald wound containing snake oil and preparation method thereof Download PDFInfo
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- CN106975096A CN106975096A CN201710286538.7A CN201710286538A CN106975096A CN 106975096 A CN106975096 A CN 106975096A CN 201710286538 A CN201710286538 A CN 201710286538A CN 106975096 A CN106975096 A CN 106975096A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B33/00—Silicon; Compounds thereof
- C01B33/113—Silicon oxides; Hydrates thereof
- C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
- C01B33/18—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof
- C01B33/181—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof by a dry process
- C01B33/183—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof by a dry process by oxidation or hydrolysis in the vapour phase of silicon compounds such as halides, trichlorosilane, monosilane
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Abstract
The present invention relates to medical dressing field, a kind of unformed dressing of the scald wound containing snake oil and preparation method thereof is disclosed.The dressing includes the raw material of following parts by weight：Aloe extracts 90 110 parts of mucus, 37 parts of polyethylene glycol, 37 parts of snake oil, 24 parts of golden cypress, 13 parts of camphor, 13 parts of sodium carboxymethylcellulose, 0.5 1.5 parts of antiseptic, 40 60 parts of alcohol, 24 parts of sodium carbonate, 36 parts of citric acid.The dressing of the present invention is on the basis of with preferable water conservation, isolation effect, also containing the Chinese medicine to treat burn and scald based on snake oil, can promote the reparation of the surface of a wound, and without preservative, it is harmless.In addition dressing of the invention is unformed dressing, copes with the surface of a wound of various areas, and the dressing also has preferably gas permeability after laying.
Description
Technical field
The present invention relates to medical dressing field, more particularly to a kind of unformed dressing of the scald wound containing snake oil and its system
Preparation Method.
Background technology
People are after by burn, and the skin at burn position can rubescent, foaming.Typically can be to wound surface smearing burn and scald
Ointment either dressing.In general traditional dressing be a kind of spawn for being laid in burn wound.It will can be created
Face is isolated from the outside, and the tissue fluid that the surface of a wound oozes out can be absorbed in time, and isolates bacterium, fungi and virus, and infection control promotees
Enter wound healing.
Patent CN201510364638.8 discloses a kind of aerogel dressing for treating burn wound, and described hydrogel is applied
Material is made up of following components：Cellulose derivative, glycerine, polyethylene glycol, propane diols, preservative, deionized water.The present invention is also carried
For the preparation method and purposes of the aerogel dressing.The invention advantage is：Cellulose derivative in described aerogel dressing
For gel-type vehicle, it can make the viscosity of dressing in optimum range, rest on wound surface, it is easy to the fixed wrapping of secondary dressing；
Glycerine, polyethylene glycol, propane diols can ensure the humidity of hydrogel, promote the liquefaction of slough；Preservative can keep gel to have
There are certain anti-corrosive properties, be unlikely to deteriorate pollution.The aerogel dressing is clear shape simultaneously, it is easy to observe wound surface healing
Situation.The aerogel dressing is unformed hydrogel, and itself autolyzed debridement is promoted by making slough slowly be hydrated, pine
Surface of a wound slough and exudate are relaxed and absorbed, the wound healing environment of a local moistening is provided for body.
Although above-mentioned dressing has preferable moisturizing, protects the effect of the surface of a wound, it is simultaneously free of for treating burn and scald
Medicine, the surface of a wound recover it is slower.And it, using hydrogel as matrix, is Styling Gel that above-mentioned dressing, which is, for the wound of different area
Contain preservative in face, it is impossible to be timely and effectively applicable, and its formula, it is harmful to human body skin to a certain extent.In addition,
The dressing is laid in skin after the surface of a wound thoroughly to be isolated with air, and gas permeability is poor, is unfavorable for surface of a wound cellular respiration, influences the surface of a wound
The secreting function of neonatal cell.
The content of the invention
In order to solve the above-mentioned technical problem, the invention provides a kind of unformed dressing of the scald wound containing snake oil and its
Preparation method.The present invention dressing on the basis of with preferable water conservation, isolation effect, also containing based on snake oil to control
The Chinese medicine of burn and scald is treated, the reparation of the surface of a wound can be promoted, and without preservative, it is harmless.In addition dressing of the invention
For unformed dressing, the surface of a wound of various areas is coped with, the dressing also has preferably gas permeability after laying.
The present invention concrete technical scheme be：A kind of unformed dressing of the scald wound containing snake oil, includes following weight
The raw material of part：
Aloe extracts 90-110 parts of mucus, 3-7 parts of polyethylene glycol, 3-7 parts of snake oil, 2-4 parts of golden cypress, 1-3 parts of camphor, carboxylic first
1-3 parts of base sodium cellulosate, 0.5-1.5 parts of antiseptic, 40-60 parts of alcohol, 2-4 parts of sodium carbonate, 3-6 parts of citric acid.
The dressing of the present invention extracts mucus as matrix from aloe, and aloe, which is extracted, contains aloe polysaccharide and anthraquinone in mucus
Class compound isoreactivity material, transparent mucus shape, the effects such as with water conservation, anti-inflammatory, antibacterial, after dermal application easily into
Film, and its skin-friendly is good, and skin will not be made to produce allergy.The dressing is different from gel dressing, is unformed shape, therefore can be with
Freely laid according to surface of a wound actual size, use more facilitates.
In addition, the present invention is added with the Chinese medicines such as snake oil, golden cypress and camphor in dressing, wherein, snake oil has pole to skin
Strong permeability, feels refrigerant when using, and has splendid compatibility and complementarity with the physiological growth feature of human skin,
Can skin care, removing toxicity for detumescence, play a part of wound repairing.Golden cypress heat-clearing and damp-drying drug, purging intense heat and detonicating, except hectic fever due to yin clearind deficient heat,
With antibacterial, convergence, anti-inflammatory effect, antibiotic can be replaced.Camphor has anesthetic effect, plays analgesia, anti-allergic effects.
Meanwhile, it has gentle stimulation and antisepsis to skin, can replace artificial preservative.To sum up, added with above-mentioned
After medicine, wound repair can be promoted.
Sodium carboxymethylcellulose has thickening and peptizaiton, it is possible to increase the stickiness of dressing and to other groups in dressing
Divide and play dispersion effect.
Preferably, the moisture content that the aloe extracts mucus is 20-30wt%.Moisture content can influence dressing into
Film is, it is necessary to rationally control.
Preferably, snake oil is handled before addition through overload：Take snake oil and be heated to 70-90 DEG C, make it
It is in a liquid state；Then the gas phase hydrophobic titanium dioxide silica flour of 0.4-0.6 times of its quality is added into snake oil, stirs, is loaded
The snake oil of processing.
Although snake oil recovers have preferable effect to empyrosis wound surface, the dressing for being due to the present invention is hydrophily base
Matter, and snake oil is oily matter, its compatibility with whole matrix is poor.After dressing preparation is finished, process is preserved in long-time
In or at relatively high temperatures, snake oil is easily precipitated and separated with matrix, and this can have a strong impact on effect of dressing.Therefore, this
Snake oil is carried on gas phase hydrophobic titanium dioxide silica flour by invention, and gas phase hydrophobic titanium dioxide silica flour has the specific surface area of superelevation, and
With hydrophobicity, snake oil can be largely loaded, so that snake oil is provided with a stable carrier, is not easily runed off.And for gas phase
Scattered then dependence sodium carboxymethylcellulose of the hydrophobic titanium dioxide silica flour itself in dressing can have preferable dispersion effect.
Preferably, the preparation method of the gas phase hydrophobic titanium dioxide silica flour is：Tetraethyl orthosilicate is used
80wt% alcoholic solution dilutes 40-50 times, and after being well mixed, acetum is added dropwise under 50-60 DEG C of water-bath, stirring condition,
Make to form colloidal sol in solution, when there is no during the formation of new colloidal sol, stop reaction；By colloidal sol aging 1-2 days at room temperature, then
The former solvent in colloidal sol is changed with organic solvent, after supercritical fluid drying removes organic solvent, pulverization process, gas is obtained
Aerosil powder；Under conditions of nitrogen protection, water flowing, 350-550 DEG C, with Trichloromethyl silane to aerosil
Powder is modified processing 2-4h, and gas phase hydrophobic titanium dioxide silica flour is made.
For the characteristic of snake oil, the present invention is using gas phase hydrophobic titanium dioxide silica flour made from the above method, with preferable
Porosity, can preferably be loaded to snake oil, and load fastness is high, snake oil can be prevented to be lost in.
Preferably, the consumption of the Trichloromethyl silane is the 8-12% of hydrophobic silica silty amount.
Preferably, the particle diameter of the gas phase hydrophobic titanium dioxide silica flour is 50-200 microns.
Preferably, the antiseptic is made up of mass ratio for 2: 1-2: 2 magnesium nitrate, ferric nitrate and copper nitrate.
Compared to traditional organic antibacterial agent with side effect and single ion antibacterial agent, the present invention is using ternary gold
Belong to ion, using the potential difference of three kinds of metals, form micro- magnetoelectricity, the antibiotic property of each ion is thorough under micro- magnetoelectricity field action
Excite, therefore there is more preferable antibacterial effect compared to classical antibacterial agents.
A kind of preparation method of the unformed dressing of the scald wound containing snake oil, step is as follows：
(a) polyethylene glycol, snake oil, golden cypress, camphor, sodium carboxymethylcellulose, antiseptic are added into aloe successively to extract
In mucus, stir, obtain sticky mixing mucus.
(b) under conditions of stirring at low speed, 1-5 DEG C, sodium carbonate and citric acid are successively added into mixing mucus, until stirring
Mix uniform.
(c) mixing mucus is stirred vigorously and heating treatment simultaneously, sodium carbonate and citric acid is fully contacted concurrently
The alveolate mucus of parcel is made after raw reaction, fully reaction.
(d) mucus of step (c) is transferred in pressure reduction vessel, alcohol is added under stirring at low speed, after stirring, taken
Go out, drain unnecessary alcohol and water, obtain the unformed dressing of the scald wound containing snake oil.
Although aloe, which extracts mucus matrix, has preferable moisture retention, its gas permeability still has much room for improvement.In dressing system
During standby, polyethylene glycol, snake oil, golden cypress, camphor, sodium carboxymethylcellulose, antiseptic are first added to aloe successively and extracted
Mucus is well mixed, and sodium carbonate and citric acid is then added, in the process, in order to prevent sodium carbonate and citric acid from shifting to an earlier date instead
Should, it is necessary to be that under low stir speed (S.S.), cryogenic conditions, addition is stirred vigorously and heated up again after finishing, and makes sodium carbonate and lemon
Lemon acid is fully contacted and reacted, and a large amount of bubbles is formed in matrix, the bubble is wrapped in dressing matrix, is stirred vigorously
Meaning is while can also be mixed into extraneous air in matrix, and is stirred vigorously and can be by the bubble splitting of large volume
The micro-bubble of multiple small sizes.Then mucus is transferred in pressure reduction vessel, under subnormal ambient, gas in bubble due to
Bubble inside and outside differential pressure is escaped, and alcohol is added under stirring at low speed, and aloe extracts solubility very little of the mucus in alcohol, because
This in whipping process alcohol can rapid osmotic enter bubble replace gas.It is made after dressing, dressing is laid on the surface of a wound
After film forming, because the specific surface area of matrix becomes big quickly, volatilized rapidly after alcohol heat absorption, refrigerant sense, and its are brought to the surface of a wound
With Disinfection Effect, be conducive to the surface of a wound to recover, reduce pain.And the micro-bubble quilt originally filled after alcohol volatilization by alcohol
Release, forms substantial amounts of capillary channel, therefore the gas permeability of dressing is improved, and has surface of a wound neonatal cell will not be by " vexed " inner
Face, is conducive to it to be breathed.
Preferably, the speed of stirring at low speed is 100-200r/min in step (b), is stirred vigorously in step (c)
Speed be 800-1200r/min, the speed of stirring at low speed is 40-80r/min in step (d).
Preferably, it is warming up to 50-60 DEG C in step (c).
It is compared with the prior art, the beneficial effects of the invention are as follows：The dressing of the present invention is with preferable water conservation, isolation effect
On the basis of, also containing the Chinese medicine to treat burn and scald based on snake oil, the reparation of the surface of a wound can be promoted, and without anti-
Rotten agent, it is harmless.In addition dressing of the invention is unformed dressing, copes with the surface of a wound of various areas, and the dressing is applied
If after also there is preferably gas permeability.
Embodiment
With reference to embodiment, the invention will be further described.
Embodiment 1
A kind of unformed dressing of the scald wound containing snake oil, includes the raw material of following parts by weight：
Aloe extracts 100 parts of mucus (moisture content is 26wt%), 4 parts of polyethylene glycol, 4 parts of snake oil, 3 parts of golden cypress, camphor 2
Part, 2 parts of sodium carboxymethylcellulose, 1 part of antiseptic (being made up of mass ratio for 2: 1.5: 2 magnesium nitrate, ferric nitrate and copper nitrate),
50 parts of alcohol, 3 parts of sodium carbonate, 5 parts of citric acid.
The preparation method of the above-mentioned unformed dressing of the scald wound containing snake oil, step is as follows：
(a) polyethylene glycol, snake oil, golden cypress, camphor, sodium carboxymethylcellulose, antiseptic are added into aloe successively to extract
In mucus, stir, obtain sticky mixing mucus.
(b) under conditions of stirring at low speed (150r/min), 3 DEG C, sodium carbonate and lemon are successively added into mixing mucus
Acid, until stirring.
(c) (1000r/min) is stirred vigorously simultaneously to mixing mucus and is warming up to 55 DEG C, make sodium carbonate and citric acid
Fully contact and react, the alveolate mucus of parcel is fully made after reaction.
(d) mucus of step (c) is transferred in pressure reduction vessel, alcohol is added under stirring at low speed (60r/min), stirred
After uniform, take out, drain unnecessary alcohol and water, obtain the unformed dressing of the scald wound containing snake oil.
Embodiment 2
A kind of unformed dressing of the scald wound containing snake oil, includes the raw material of following parts by weight：
Aloe extracts 100 parts of mucus (moisture content is 26wt%), 4 parts of polyethylene glycol, 4 parts of snake oil, 3 parts of golden cypress, camphor 2
Part, 2 parts of sodium carboxymethylcellulose, 1 part of antiseptic (being made up of mass ratio for 2: 1.5: 2 magnesium nitrate, ferric nitrate and copper nitrate),
50 parts of alcohol, 3 parts of sodium carbonate, 5 parts of citric acid.
Wherein, snake oil is handled before addition through overload：Take snake oil and be heated to 80 DEG C, it is in a liquid state；Then
The gas phase hydrophobic titanium dioxide silica flour of 0.5 times of its quality is added into snake oil, is stirred, the snake oil of load processing is obtained.
The preparation method of the gas phase hydrophobic titanium dioxide silica flour is：Tetraethyl orthosilicate is dilute with 80wt% alcoholic solution
45 times are released, after being well mixed, acetum is added dropwise under 550 DEG C of water-baths, stirring conditions, makes to form colloidal sol in solution, when no longer
When having new colloidal sol formation, stop reaction；By colloidal sol aging 1.5 days at room temperature, then changed with organic solvent in colloidal sol
Former solvent, after supercritical fluid drying removes organic solvent, pulverization process, obtains the gas phase two that particle diameter is 50-200 microns
Silica powder；Under conditions of nitrogen protection, water flowing, 450 DEG C, with Trichloromethyl silane (hydrophobic silica silty amount
10%) processing 3h is modified to aerosil powder, gas phase hydrophobic titanium dioxide silica flour is made.
The preparation method of the above-mentioned unformed dressing of the scald wound containing snake oil, step is as follows：
(a) polyethylene glycol, snake oil, golden cypress, camphor, sodium carboxymethylcellulose, antiseptic are added into aloe successively to extract
In mucus, stir, obtain sticky mixing mucus.
(b) under conditions of stirring at low speed (150r/min), 3 DEG C, sodium carbonate and lemon are successively added into mixing mucus
Acid, until stirring.
(c) (1000r/min) is stirred vigorously simultaneously to mixing mucus and is warming up to 55 DEG C, make sodium carbonate and citric acid
Fully contact and react, the alveolate mucus of parcel is fully made after reaction.
(d) mucus of step (c) is transferred in pressure reduction vessel, alcohol is added under stirring at low speed (60r/min), stirred
After uniform, take out, drain unnecessary alcohol and water, obtain the unformed dressing of the scald wound containing snake oil.
Embodiment 3
A kind of unformed dressing of the scald wound containing snake oil, includes the raw material of following parts by weight：
90 parts of aloe extraction mucus (moisture content is 20wt%), 7 parts of polyethylene glycol, 3 parts of snake oil, 4 parts of golden cypress, 1 part of camphor,
3 parts of sodium carboxymethylcellulose, 0.5 part of antiseptic (being made up of mass ratio for 2: 1: 2 magnesium nitrate, ferric nitrate and copper nitrate), wine
40 parts of essence, 2 parts of sodium carbonate, 3 parts of citric acid.
Wherein, snake oil is handled before addition through overload：Take snake oil and be heated to 70 DEG C, it is in a liquid state；Then
The gas phase hydrophobic titanium dioxide silica flour of 0.4 times of its quality is added into snake oil, is stirred, the snake oil of load processing is obtained.
The preparation method of the gas phase hydrophobic titanium dioxide silica flour is：Tetraethyl orthosilicate is dilute with 80wt% alcoholic solution
Release 40 times, be well mixed after, acetum is added dropwise under 50 DEG C of water-baths, stirring conditions, makes to form colloidal sol in solution, when there is no
When new colloidal sol is formed, stop reaction；By colloidal sol aging 1 day at room temperature, then changed with organic solvent former molten in colloidal sol
Agent, after supercritical fluid drying removes organic solvent, pulverization process, obtains the gas phase titanium dioxide that particle diameter is 50-200 microns
Silica flour；Under conditions of nitrogen protection, water flowing, 350 DEG C, with Trichloromethyl silane (the 8% of hydrophobic silica silty amount)
Processing 2h is modified to aerosil powder, gas phase hydrophobic titanium dioxide silica flour is made.
The preparation method of the above-mentioned unformed dressing of the scald wound containing snake oil, step is as follows：
(a) polyethylene glycol, snake oil, golden cypress, camphor, sodium carboxymethylcellulose, antiseptic are added into aloe successively to extract
In mucus, stir, obtain sticky mixing mucus.
(b) under conditions of stirring at low speed (100r/min), 1 DEG C, sodium carbonate and lemon are successively added into mixing mucus
Acid, until stirring.
(c) (800r/min) is stirred vigorously simultaneously to mixing mucus and is warming up to 50 DEG C, make sodium carbonate and citric acid
Fully contact and react, the alveolate mucus of parcel is fully made after reaction.
(d) mucus of step (c) is transferred in pressure reduction vessel, alcohol is added under stirring at low speed (40r/min), stirred
After uniform, take out, drain unnecessary alcohol and water, obtain the unformed dressing of the scald wound containing snake oil.
Embodiment 4
A kind of unformed dressing of the scald wound containing snake oil, includes the raw material of following parts by weight：
Aloe extracts 110 parts of mucus (moisture content is 30wt%), 3 parts of polyethylene glycol, 7 parts of snake oil, 2 parts of golden cypress, camphor 3
Part, 1 part of sodium carboxymethylcellulose, 1.5 parts of antiseptic (being made up of mass ratio for 2: 2: 2 magnesium nitrate, ferric nitrate and copper nitrate),
60 parts of alcohol, 4 parts of sodium carbonate, 6 parts of citric acid.
Wherein, snake oil is handled before addition through overload：Take snake oil and be heated to 90 DEG C, it is in a liquid state；Then
The gas phase hydrophobic titanium dioxide silica flour of 0.6 times of its quality is added into snake oil, is stirred, the snake oil of load processing is obtained.
The preparation method of the gas phase hydrophobic titanium dioxide silica flour is：Tetraethyl orthosilicate is dilute with 80wt% alcoholic solution
Release 50 times, be well mixed after, acetum is added dropwise under 60 DEG C of water-baths, stirring conditions, makes to form colloidal sol in solution, when there is no
When new colloidal sol is formed, stop reaction；By colloidal sol aging 2 days at room temperature, then changed with organic solvent former molten in colloidal sol
Agent, after supercritical fluid drying removes organic solvent, pulverization process, obtains the gas phase titanium dioxide that particle diameter is 50-200 microns
Silica flour；Under conditions of nitrogen protection, water flowing, 550 DEG C, with Trichloromethyl silane (the 12% of hydrophobic silica silty amount)
Processing 4h is modified to aerosil powder, gas phase hydrophobic titanium dioxide silica flour is made.
The preparation method of the above-mentioned unformed dressing of the scald wound containing snake oil, step is as follows：
(a) polyethylene glycol, snake oil, golden cypress, camphor, sodium carboxymethylcellulose, antiseptic are added into aloe successively to extract
In mucus, stir, obtain sticky mixing mucus.
(b) under conditions of stirring at low speed (200r/min), 5 DEG C, sodium carbonate and lemon are successively added into mixing mucus
Acid, until stirring.
(c) (1200r/min) is stirred vigorously simultaneously to mixing mucus and is warming up to 60 DEG C, make sodium carbonate and citric acid
Fully contact and react, the alveolate mucus of parcel is fully made after reaction.
(d) mucus of step (c) is transferred in pressure reduction vessel, alcohol is added under stirring at low speed (80r/min), stirred
After uniform, take out, drain unnecessary alcohol and water, obtain the unformed dressing of the scald wound containing snake oil.
The dressing of the dressing of embodiment 1 and embodiment 2 and common hydrogel matrix (comparative example) on the market is carried out
Contrast on effect.
Using the male adult rats of SD as subjects, it is carried out after II scalds, laid after each dressing (except control group),
The complete healing time of the surface of a wound is recorded, it is as a result as follows：
| Group number | Average surface of a wound area | Average complete healing time |
| Control group | 5±0.18cm2 | 16 days |
| Comparative example | 5±0.22cm2 | 11 days |
| Embodiment 1 | 5±0.21cm2 | 8 days |
| Embodiment 2 | 5±0.21cm2 | 8 days |
Dressing to Examples 1 and 2 carries out storage stability test, and the dressing of Examples 1 and 2 is protected at normal temperatures
Deposit, observe dressing outward appearance and carry out recording observation situation.
Raw materials used in the present invention, equipment, is the conventional raw material, equipment of this area unless otherwise noted；In the present invention
Method therefor, is the conventional method of this area unless otherwise noted.
It is described above, only it is presently preferred embodiments of the present invention, not the present invention is imposed any restrictions, it is every according to the present invention
Any simple modification, change and equivalent transformation that technical spirit is made to above example, still fall within the technology of the present invention side
The protection domain of case.
Claims (10)
1. a kind of unformed dressing of the scald wound containing snake oil, it is characterised in that：Include the raw material of following parts by weight：
Aloe extracts 90-110 parts of mucus,
3-7 parts of polyethylene glycol,
3-7 parts of snake oil,
2-4 parts of golden cypress,
1-3 parts of camphor,
1-3 parts of sodium carboxymethylcellulose,
0.5-1.5 parts of antiseptic,
40-60 parts of alcohol,
2-4 parts of sodium carbonate,
3-6 parts of citric acid.
2. a kind of unformed dressing of the scald wound containing snake oil as claimed in claim 1, it is characterised in that：The aloe carries
The moisture content for taking mucus is 20-30wt%.
3. a kind of unformed dressing of the scald wound containing snake oil as claimed in claim 1, it is characterised in that：Snake oil is in addition
It is preceding to be handled through overload：Take snake oil and be heated to 70-90 DEG C, it is in a liquid state；Then its quality is added into snake oil
0.4-0.6 times of gas phase hydrophobic titanium dioxide silica flour, stirs, and obtains the snake oil of load processing.
4. a kind of unformed dressing of the scald wound containing snake oil as claimed in claim 3, it is characterised in that：The gas phase is dredged
The preparation method of water silicon dioxide powder is：Tetraethyl orthosilicate is diluted 40-50 times with 80wt% alcoholic solution, is well mixed
Afterwards, acetum is added dropwise under 50-60 DEG C of water-bath, stirring condition, makes to form colloidal sol in solution, formed when there is no new colloidal sol
When, stop reaction；By colloidal sol aging 1-2 days at room temperature, the former solvent in colloidal sol then is changed with organic solvent, is faced by super
Boundary's fluid drying is removed after organic solvent, pulverization process, obtains aerosil powder；In nitrogen protection, water flowing, 350-550
Under conditions of DEG C, processing 2-4h is modified to aerosil powder with Trichloromethyl silane, the hydrophobic dioxy of gas phase is made
SiClx powder.
5. a kind of unformed dressing of the scald wound containing snake oil as claimed in claim 4, it is characterised in that：The monomethyl
The consumption of trichlorosilane is the 8-12% of hydrophobic silica silty amount.
6. a kind of unformed dressing of the scald wound containing snake oil as claimed in claim 3, it is characterised in that：The gas phase is dredged
The particle diameter of water silicon dioxide powder is 50-200 microns.
7. a kind of unformed dressing of the scald wound containing snake oil as claimed in claim 1, it is characterised in that：The antiseptic
It is made up of mass ratio for 2: 1-2: 2 magnesium nitrate, ferric nitrate and copper nitrate.
8. a kind of preparation method of unformed dressing of the scald wound containing snake oil as described in claim 1-7 is any, it is special
Levy and be that step is as follows：
(a) polyethylene glycol, snake oil, golden cypress, camphor, sodium carboxymethylcellulose, antiseptic are added to aloe successively and extract mucus
In, stir, obtain sticky mixing mucus；
(b) under conditions of stirring at low speed, 1-5 DEG C, sodium carbonate and citric acid are successively added into mixing mucus, until stirring is equal
It is even；
(c) mixing mucus is stirred vigorously and heating treatment simultaneously, sodium carbonate and citric acid is fully contacted and is occurred anti-
Should, the alveolate mucus of parcel is fully made after reaction；
(d) mucus of step (c) is transferred in pressure reduction vessel, alcohol is added under stirring at low speed, after stirring, taken out,
Unnecessary alcohol and water is drained, the unformed dressing of the scald wound containing snake oil is obtained.
9. a kind of preparation method of the unformed dressing of the scald wound containing snake oil as claimed in claim 8, it is characterised in that：
The speed of stirring at low speed is 100-200r/min in step (b), and the speed being stirred vigorously in step (c) is 800-1200r/min,
The speed of stirring at low speed is 40-80r/min in step (d).
10. a kind of preparation method of the unformed dressing of the scald wound containing snake oil as claimed in claim 8, its feature exists
In：50-60 DEG C is warming up in step (c).
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110354301A (en) * | 2019-06-05 | 2019-10-22 | 西安惠普生物科技有限公司 | A kind of aerosol silicone dressing and purposes |
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| CN103638307A (en) * | 2013-11-15 | 2014-03-19 | 周荣庆 | Snake oil moistening scald ointment |
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| CN102264400A (en) * | 2008-12-31 | 2011-11-30 | 凯希特许有限公司 | Bioresorbable foaming tissue dressing |
| CN102049062A (en) * | 2009-10-30 | 2011-05-11 | 华东理工大学 | Injectable efficient suspended stable calcium phosphate cement and preparation method and application thereof |
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| CN110354301A (en) * | 2019-06-05 | 2019-10-22 | 西安惠普生物科技有限公司 | A kind of aerosol silicone dressing and purposes |
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