CN108096224A - A kind of infantile umbilical paste - Google Patents
A kind of infantile umbilical paste Download PDFInfo
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- CN108096224A CN108096224A CN201711491539.1A CN201711491539A CN108096224A CN 108096224 A CN108096224 A CN 108096224A CN 201711491539 A CN201711491539 A CN 201711491539A CN 108096224 A CN108096224 A CN 108096224A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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Abstract
The present invention provides a kind of infantile umbilical pastes, belong to medical assistant product technical field.Infantile umbilical paste of the present invention is stacked gradually by back sheet, aerogel layer, inanimate matter/chitosan composite bed and adherent layer, and wherein inanimate matter/chitosan composite bed is by 8 water barium hydroxides and chitosan liquid in mass ratio 1：10~1：15 are stirred, and are concentrated under reduced pressure, crystallisation by cooling, filtering, and obtained by cold moudling, chitosan liquid is by chitosan and water in mass ratio 1：10~1：20 mixing add the chitosan enzyme of chitosan mass 3%~5%, enzymolysis, enzyme deactivation gained, aerogel layer adds in metal salt solution by ethyl orthosilicate dispersion liquid heating reflux reaction, injection molding, sealing and standing, the demoulding, washing, and be dried to obtain, back sheet and adherent layer use non-woven fabrics.Gained infantile umbilical paste of the invention has excellent cooling-down effect.
Description
Technical field
The present invention provides a kind of infantile umbilical pastes, belong to medical assistant product technical field.
Background technology
It is defervescence plaster used, have and bring down a fever cooling effect, can alleviate catch a cold cause with fever, headache and toothache, solarization, muscle
Pain heat symptom-complex shape caused by spraining.Can be used by individual demand, every cooling effect can last about 10 it is small when.It is torn during use along notch
Packaging bag takes out patch, opens transparent membrane, be directly applied to forehead or temple, can also be applied to neck Dazhui acupoint：In order to
Accelerate cooling rate, number can be sticked on simultaneously and be affixed on human body Arteria carotis communis, left and right axillary arteries, at the femoral artery of left and right.It can press
It is used according to position size is used to cut.
High-molecular gel be macromolecular be cross-linked with each other to form three-dimensional network, there are the polyploids of big quantity of fluid in a network
System, in medicine and bioengineering using it is more be hydrogel.Macromolecule hydrogel is by three-dimensional cross-linked macromolecule network
It with the multicomponent system of water composition, can be swollen in water, and keep large quantity of moisture and do not dissolve.Hydrogel has good parent
The performances such as aqueous and biocompatibility, have been widely used in medicine, cosmetics, industrial goods, agricultural and civil engineering in recent years
Etc..Traditional physics is brought down a fever, and method has ice bag cooling, cold water towel application cools down, alcohol is rubbed one's body with a towel, but these methods are all
Have the shortcomings that inconvenient for use.Macromolecule hydrogel is defervescence plaster used using macromolecule hydrogel as matrix, by substantial amounts of water and natural on a small quantity
Freshener is carried in high-molecular gel, by the evaporation endothermic of water, the heat generated during human body fever is taken away, so as to reach drop
The effect that temperature is brought down a fever has Physical temperature-lowering and the double effects of natural freshener cooling.Hydrogel can be straight with the adhesion strength of itself
It connects and is pasted on forehead etc., " epilation pain " when being not required to other fixation, and not removing.It is defervescence plaster used with macromolecule hydrogel
It is the external use plaster of matrix scaffold material for the water soluble polymer that represents, is that the percutaneous dosing developed in the latest 20 years is new
Dosage form.Percutaneous dosing, which has, avoids gastrointestinal environment that from can extending half-life period shorter medicine to the interference of drug effect and liver " first pass effect "
The therapeutic effect of object can maintain stable medicine-feeding rate, have a vast market development prospect for a long time.But tradition is brought down a fever at present
Patch also there are cooling-down effect it is bad the problem of, therefore also need to study it.
The content of the invention
The present invention solves the technical problem of：For the defervescence plaster used cooling-down effect of tradition it is bad the problem of, provide one
Kind infantile umbilical paste.
In order to solve the above-mentioned technical problem, the technical solution adopted in the present invention is：
A kind of infantile umbilical paste including back sheet and adherent layer, further includes aerogel layer and inanimate matter/chitosan composite bed；
The aerogel layer preparation process is：Ethyl orthosilicate dispersion liquid pH is adjusted to 6.0~6.2, after heating reflux reaction,
Ammonium hydroxide is added dropwise, adjusts pH to 8.6~8.8, adds the metal salt solution of 0.1 ~ 0.2 times of ethyl orthosilicate dispersion liquid quality, stir
After mixing mixing, injection molding, 36~72h of sealing and standing is demoulded, washing, and drying to moisture content is 10~15%, obtains aerogel layer；
The inanimate matter/chitosan composite bed preparation process is：By barium hydroxide and chitosan liquid in mass ratio 1：10~
1：15 are stirred, and are concentrated under reduced pressure, crystallisation by cooling, and filtering, cold moudling is to get inanimate matter/chitosan composite bed；
The infantile umbilical paste preparation process is：By back sheet, aerogel layer, inanimate matter/chitosan composite bed and adherent layer according to
Secondary stacking is compound to get infantile umbilical paste.
The preparation process of the chitosan liquid is：By chitosan and water in mass ratio 1：10~1：20 mixing, add shell
The chitosan enzyme of glycan quality 3~5%, enzymolysis, enzyme deactivation obtain chitosan liquid.
The metal salt solution is configured by following parts by weight raw material：8~10 parts of ammonium chlorides, 3~5 parts of chlorinations
Zinc, 4~6 parts of ferric nitrates, 100~120 parts of water.
It by ethyl orthosilicate and mass fraction is 40% ethanol solution in mass ratio 1 that the ethyl orthosilicate dispersion liquid, which is,：3
~1：5 mixing are scattered to be obtained.
The back sheet uses non-woven fabrics of the thickness for 3~5mm.
The adherent layer uses non-woven fabrics of the thickness for 2~3mm.
The beneficial effects of the invention are as follows：
（1）Technical solution of the present invention can be hydrolyzed by adding metal salt, metal salt in system in system, metal salt
Hydrolysis is the endothermic reaction, is conducive to system internal cooling, by that under the excellent thermal insulation function of aerogel layer, can keep away
Exempt to spread in system inner cryogenic external environment, system is made to remain relatively low temperature, play product good long-acting
Cooling-down effect, in addition, aerosil has a good hygroscopicity, absorbable human body sends out moisture and air thermogenetic
In moisture, increase moisture in aerosil system, so as to accelerate the hydrolysis and chlorination of system interior metal salt
Diffusion of the ammonium in system, so that ammonium chloride and barium hydroxide haptoreaction, and the reaction of the two is anti-for heat absorption
Should, the effect further to cool down can be played；
（2）Technical solution of the present invention is by adding the chitosan after digesting activation, under system Action of Metal Ions, after activation
It can occur coordination cross-linked between chitosan molecule, so as to form three-dimensional crosslinked network, and the formation of cross-linked network can be molten by metal salt
The absorption of liquid hydrolysate is fixed, and so as to break hydrolysis balance, the hydrolysis of metal salt in system is made to balance towards heat release
The Direction of Reaction carries out, the absorbing and cooling temperature effect of further enhanced products.
Specific embodiment
Ethyl orthosilicate dispersion liquid mass fraction is adjusted into pH to 6.0~6.2 for 10% salpeter solution, is then at temperature
Mass fraction, which is added dropwise, under the conditions of 65~70 DEG C, in 2~4h of heating reflux reaction, then ethyl orthosilicate dispersion liquid after reaction is
10~15% ammonium hydroxide, adjust pH to 8.6~8.8, band pH adjusting terminates, add ethyl orthosilicate dispersion liquid quality 0.1~
0.2 times of metal salt solution, and after being stirred 10~20min with glass bar, injection molding, then by mold under room temperature, it is close
Envelope stands 36~72h, and the demoulding obtains blank, and blank is washed with deionized 3~5 times, then the blank after washing is moved into baking oven
In, under the conditions of temperature is 75~80 DEG C, drying to moisture content is 10~15%, and discharging obtains aerogel layer；By chitosan and water
In mass ratio 1：10~1：20 add in three-necked flasks, and three-necked flask immigration digital display is tested the speed in constant temperature blender with magnetic force, in
Temperature is 75~90 DEG C, and constant temperature is stirred 2~3h under the conditions of rotating speed is 300~500r/min, is cooled to 30~35 DEG C, then
The chitosan enzyme of chitosan mass 3~5% is added in into three-necked flask, is 30~35 DEG C in temperature, rotating speed is 400~600r/
Under the conditions of min, after 2~4h of constant temperature stirring enzymolysis, 10~15min of enzyme deactivation is kept the temperature under the conditions of temperature is 90~95 DEG C, cooling obtains
Chitosan liquid；By barium hydroxide and chitosan liquid in mass ratio 1：10~1：15 add in beaker, are stirred with glass bar mixed
Close 10~20min, obtain mixed liquor, and gained mixed liquor is transferred to Rotary Evaporators, in temperature be 75~85 DEG C, pressure 600
Under the conditions of~800kPa, be concentrated under reduced pressure 2~4h, obtains concentrate, then gained concentrate is moved into refrigerator, cold for 2~3 DEG C in temperature
But crystallization 12~for 24 hours, filtering obtains filter residue, and is 20~25 DEG C in temperature by gained filter residue, under the conditions of pressure is 10~20MPa,
Cold moudling obtains inanimate matter/chitosan composite bed；By back sheet, aerogel layer, inanimate matter/chitosan composite bed and adherent layer
It stacks gradually compound to get infantile umbilical paste.The metal salt solution is configured by following parts by weight raw material：8~10
Part ammonium chloride, 3~5 parts of zinc chloride, 4~6 parts of ferric nitrates, 100~120 parts of water.The ethyl orthosilicate dispersion liquid is by positive silicon
Acetoacetic ester and mass fraction are 40% ethanol solution in mass ratio 1：3~1：5 mixing are scattered to be obtained.The back sheet uses thickness
For the non-woven fabrics of 3~5mm.The adherent layer uses non-woven fabrics of the thickness for 2~3mm.
Example 1
Ethyl orthosilicate dispersion liquid mass fraction is adjusted into pH to 6.2 for 10% salpeter solution, is 70 DEG C of conditions then at temperature
Under, the ammonium hydroxide that mass fraction is 15% is added dropwise in heating reflux reaction 4h, then ethyl orthosilicate dispersion liquid after reaction, adjusts
PH to 8.8, band pH adjustings terminate, add the metal salt solution of 0.2 times of ethyl orthosilicate dispersion liquid quality, and stirred with glass bar
After mixing mixing 20min, injection molding, then by mold under room temperature, sealing and standing 72h, the demoulding obtains blank, and uses deionized water
It washs blank 5 times, then the blank after washing is moved into baking oven, under the conditions of temperature is 80 DEG C, drying to moisture content is 15%,
Discharging, obtains aerogel layer；By chitosan and water in mass ratio 1：20 add in three-necked flask, and three-necked flask is moved into digital display and is surveyed
It it is 90 DEG C in temperature, constant temperature is stirred 3h under the conditions of rotating speed is 500r/min, is cooled to 35 in fast constant temperature blender with magnetic force
DEG C, then into three-necked flask add in chitosan mass 5% chitosan enzyme, in temperature be 35 DEG C, rotating speed be 600r/min conditions
Under, after constant temperature stirring enzymolysis 4h, enzyme deactivation 15min is kept the temperature under the conditions of temperature is 95 DEG C, cooling obtains chitosan liquid；By eight water hydrogen
Barium monoxide and chitosan liquid in mass ratio 1：15 add in beakers, are stirred 20min with glass bar, obtain mixed liquor, and by institute
It obtaining mixed liquor and is transferred to Rotary Evaporators, be 85 DEG C in temperature, under the conditions of pressure is 800kPa, be concentrated under reduced pressure 4h, obtains concentrate, then
By gained concentrate move into refrigerator, in temperature for 3 DEG C of crystallisation by cooling for 24 hours, filtering, obtain filter residue, and be in temperature by gained filter residue
25 DEG C, under the conditions of pressure is 20MPa, cold moudling obtains inanimate matter/chitosan composite bed；By back sheet, aerogel layer is inorganic
Matter/chitosan composite bed and adherent layer stack gradually compound to get infantile umbilical paste.The metal salt solution is by following weight
Number raw material configures：10 parts of ammonium chlorides, 5 parts of zinc chloride, 6 parts of ferric nitrates, 120 parts of water.The ethyl orthosilicate dispersion liquid
It by ethyl orthosilicate and mass fraction is 40% ethanol solution in mass ratio 1 to be：5 mixing are scattered to be obtained.The back sheet is using thick
Spend the non-woven fabrics for 5mm.The adherent layer uses non-woven fabrics of the thickness for 3mm.
Example 2
Ethyl orthosilicate dispersion liquid mass fraction is adjusted into pH to 6.2 for 10% salpeter solution, is 70 DEG C of conditions then at temperature
Under, the ammonium hydroxide that mass fraction is 15% is added dropwise in heating reflux reaction 4h, then ethyl orthosilicate dispersion liquid after reaction, adjusts
PH to 8.8, band pH adjustings terminate, add the metal salt solution of 0.2 times of ethyl orthosilicate dispersion liquid quality, and stirred with glass bar
After mixing mixing 20min, injection molding, then by mold under room temperature, sealing and standing 72h, the demoulding obtains blank, and uses deionized water
It washs blank 5 times, then the blank after washing is moved into baking oven, under the conditions of temperature is 80 DEG C, drying to moisture content is 15%,
Discharging, obtains aerogel layer；By chitosan and water in mass ratio 1：20 add in three-necked flask, and three-necked flask is moved into digital display and is surveyed
It it is 90 DEG C in temperature, constant temperature is stirred 3h under the conditions of rotating speed is 500r/min, is cooled to 35 in fast constant temperature blender with magnetic force
DEG C, then into three-necked flask add in chitosan mass 5% chitosan enzyme, in temperature be 35 DEG C, rotating speed be 600r/min conditions
Under, after constant temperature stirring enzymolysis 4h, enzyme deactivation 15min is kept the temperature under the conditions of temperature is 95 DEG C, cooling obtains chitosan liquid；By eight water hydrogen
Barium monoxide and chitosan liquid in mass ratio 1：15 add in beakers, are stirred 20min with glass bar, obtain mixed liquor, and by institute
It obtaining mixed liquor and is transferred to Rotary Evaporators, be 85 DEG C in temperature, under the conditions of pressure is 800kPa, be concentrated under reduced pressure 4h, obtains concentrate, then
By gained concentrate move into refrigerator, in temperature for 3 DEG C of crystallisation by cooling for 24 hours, filtering, obtain filter residue, and be in temperature by gained filter residue
25 DEG C, under the conditions of pressure is 20MPa, cold moudling obtains inanimate matter/chitosan composite bed；By back sheet, aerogel layer is inorganic
Matter/chitosan composite bed and adherent layer stack gradually compound to get infantile umbilical paste.The metal salt solution is by following weight
Number raw material configures：5 parts of zinc chloride, 6 parts of ferric nitrates, 120 parts of water.The ethyl orthosilicate dispersion liquid is by positive silicic acid second
Ester and mass fraction are 40% ethanol solution in mass ratio 1：5 mixing are scattered to be obtained.The back sheet uses nothing of the thickness for 5mm
Woven fabric.The adherent layer uses non-woven fabrics of the thickness for 3mm.
Example 3
Ethyl orthosilicate dispersion liquid mass fraction is adjusted into pH to 6.2 for 10% salpeter solution, is 70 DEG C of conditions then at temperature
Under, the ammonium hydroxide that mass fraction is 15% is added dropwise in heating reflux reaction 4h, then ethyl orthosilicate dispersion liquid after reaction, adjusts
PH to 8.8, band pH adjustings terminate, add the ammonium chloride solution of 0.2 times of ethyl orthosilicate dispersion liquid quality, and stirred with glass bar
After mixing mixing 20min, injection molding, then by mold under room temperature, sealing and standing 72h, the demoulding obtains blank, and uses deionized water
It washs blank 5 times, then the blank after washing is moved into baking oven, under the conditions of temperature is 80 DEG C, drying to moisture content is 15%,
Discharging, obtains aerogel layer；By chitosan and water in mass ratio 1：20 add in three-necked flask, and three-necked flask is moved into digital display and is surveyed
It it is 90 DEG C in temperature, constant temperature is stirred 3h under the conditions of rotating speed is 500r/min, is cooled to 35 in fast constant temperature blender with magnetic force
DEG C, then into three-necked flask add in chitosan mass 5% chitosan enzyme, in temperature be 35 DEG C, rotating speed be 600r/min conditions
Under, after constant temperature stirring enzymolysis 4h, enzyme deactivation 15min is kept the temperature under the conditions of temperature is 95 DEG C, cooling obtains chitosan liquid；By eight water hydrogen
Barium monoxide and chitosan liquid in mass ratio 1：15 add in beakers, are stirred 20min with glass bar, obtain mixed liquor, and by institute
It obtaining mixed liquor and is transferred to Rotary Evaporators, be 85 DEG C in temperature, under the conditions of pressure is 800kPa, be concentrated under reduced pressure 4h, obtains concentrate, then
By gained concentrate move into refrigerator, in temperature for 3 DEG C of crystallisation by cooling for 24 hours, filtering, obtain filter residue, and be in temperature by gained filter residue
25 DEG C, under the conditions of pressure is 20MPa, cold moudling obtains inanimate matter/chitosan composite bed；By back sheet, aerogel layer is inorganic
Matter/chitosan composite bed and adherent layer stack gradually compound to get infantile umbilical paste.The ethyl orthosilicate dispersion liquid is by just
Silester and mass fraction are 40% ethanol solution in mass ratio 1：5 mixing are scattered to be obtained.The back sheet use thickness for
The non-woven fabrics of 5mm.The adherent layer uses non-woven fabrics of the thickness for 3mm.
Example 4
By chitosan and water in mass ratio 1：20 add in three-necked flasks, and the three-necked flask immigration digital display constant temperature magnetic force that tests the speed is stirred
It mixes in device, is 90 DEG C in temperature, constant temperature is stirred 3h under the conditions of rotating speed is 500r/min, is cooled to 35 DEG C, then to three mouthfuls
The chitosan enzyme of chitosan mass 5% is added in flask, is 35 DEG C in temperature, under the conditions of rotating speed is 600r/min, constant temperature stirs enzyme
After solving 4h, enzyme deactivation 15min is kept the temperature under the conditions of temperature is 95 DEG C, cooling obtains chitosan liquid；By barium hydroxide and chitosan
Liquid in mass ratio 1：15 add in beaker, are stirred 20min with glass bar, obtain mixed liquor, and gained mixed liquor is transferred to rotation
Turn evaporimeter, be 85 DEG C in temperature, under the conditions of pressure is 800kPa, be concentrated under reduced pressure 4h, obtains concentrate, then gained concentrate is moved
Enter refrigerator, in temperature for 3 DEG C of crystallisation by cooling for 24 hours, filtering obtains filter residue, and is 25 DEG C in temperature by gained filter residue, and pressure is
Under the conditions of 20MPa, cold moudling obtains inanimate matter/chitosan composite bed；By back sheet, inanimate matter/chitosan composite bed and anti-sticking
Layer stacks gradually compound to get infantile umbilical paste.The metal salt solution is configured by following parts by weight raw material：10 parts
Ammonium chloride, 5 parts of zinc chloride, 6 parts of ferric nitrates, 120 parts of water.The ethyl orthosilicate dispersion liquid is by ethyl orthosilicate and quality point
Number is 40% ethanol solution in mass ratio 1：5 mixing are scattered to be obtained.The back sheet uses non-woven fabrics of the thickness for 5mm.It is described anti-
Adhesion coating uses non-woven fabrics of the thickness for 3mm.
Example 5
Ethyl orthosilicate dispersion liquid mass fraction is adjusted into pH to 6.2 for 10% salpeter solution, is 70 DEG C of conditions then at temperature
Under, the ammonium hydroxide that mass fraction is 15% is added dropwise in heating reflux reaction 4h, then ethyl orthosilicate dispersion liquid after reaction, adjusts
PH to 8.8, band pH adjustings terminate, add the metal salt solution of 0.2 times of ethyl orthosilicate dispersion liquid quality, and stirred with glass bar
After mixing mixing 20min, injection molding, then by mold under room temperature, sealing and standing 72h, the demoulding obtains blank, and uses deionized water
It washs blank 5 times, then the blank after washing is moved into baking oven, under the conditions of temperature is 80 DEG C, drying to moisture content is 15%,
Discharging, obtains aerogel layer；By barium hydroxide and water in mass ratio 1：15 add in beaker, are stirred with glass bar
20min obtains mixed liquor, and gained mixed liquor is transferred to Rotary Evaporators, in temperature be 85 DEG C, pressure be 800kPa under the conditions of,
Be concentrated under reduced pressure 4h, obtains concentrate, then gained concentrate is moved into refrigerator, in temperature for 3 DEG C of crystallisation by cooling for 24 hours, filtering must filter
Slag, and be 25 DEG C in temperature by gained filter residue, under the conditions of pressure is 20MPa, cold moudling obtains inanimate matter layer；By back sheet, gas
Gel layer, inanimate matter layer and adherent layer stack gradually compound to get infantile umbilical paste.The metal salt solution is by following weight
Number raw material configures：10 parts of ammonium chlorides, 5 parts of zinc chloride, 6 parts of ferric nitrates, 120 parts of water.The ethyl orthosilicate dispersion liquid
It by ethyl orthosilicate and mass fraction is 40% ethanol solution in mass ratio 1 to be：5 mixing are scattered to be obtained.The back sheet is using thick
Spend the non-woven fabrics for 5mm.The adherent layer uses non-woven fabrics of the thickness for 3mm.
Comparative example：Certain commercially available infantile umbilical paste.
Defervescence plaster used and comparative example product obtained by example 1 to 5 is subjected to performance detection, specific detection method is as follows：
Sticked respectively to children, 3~5 years old children, 6~10 years old children and adults within catching a cold 1 years old of fever state it is defervescence plaster used,
After this defervescence plaster used 15min and 1h, lower body-temp. reducing is measured.Specific testing result is as shown in table 1：
Table 1：Performance detection table
From 1 testing result of table, present invention gained infantile umbilical paste has excellent cooling-down effect.
Claims (6)
1. a kind of infantile umbilical paste, including back sheet and adherent layer, it is characterised in that：Further include aerogel layer and inanimate matter/shell
Glycan composite bed；
The aerogel layer preparation process is：Ethyl orthosilicate dispersion liquid pH is adjusted to 6.0~6.2, after heating reflux reaction,
Ammonium hydroxide is added dropwise, adjusts pH to 8.6~8.8, adds the metal salt solution of 0.1 ~ 0.2 times of ethyl orthosilicate dispersion liquid quality, stir
After mixing mixing, injection molding, 36~72h of sealing and standing is demoulded, washing, and drying to moisture content is 10~15%, obtains aerogel layer；
The inanimate matter/chitosan composite bed preparation process is：By barium hydroxide and chitosan liquid in mass ratio 1：10~
1：15 are stirred, and are concentrated under reduced pressure, crystallisation by cooling, and filtering, cold moudling is to get inanimate matter/chitosan composite bed；
The infantile umbilical paste preparation process is：By back sheet, aerogel layer, inanimate matter/chitosan composite bed and adherent layer according to
Secondary stacking is compound to get infantile umbilical paste.
2. a kind of infantile umbilical paste according to claim 1, it is characterised in that：The preparation process of the chitosan liquid is：It will
Chitosan and water in mass ratio 1：10~1：20 mixing, add the chitosan enzyme of chitosan mass 3~5%, enzymolysis, and enzyme deactivation obtains
Chitosan liquid.
3. a kind of infantile umbilical paste according to claim 1, it is characterised in that：The metal salt solution is by following parts by weight
Number raw material configures：8~10 parts of ammonium chlorides, 3~5 parts of zinc chloride, 4~6 parts of ferric nitrates, 100~120 parts of water.
4. a kind of infantile umbilical paste according to claim 1, it is characterised in that：The ethyl orthosilicate dispersion liquid is by positive silicon
Acetoacetic ester and mass fraction are 40% ethanol solution in mass ratio 1：3~1：5 mixing are scattered to be obtained.
5. a kind of infantile umbilical paste according to claim 1, it is characterised in that：The back sheet uses thickness as 3~5mm's
Non-woven fabrics.
6. a kind of infantile umbilical paste according to claim 1, it is characterised in that：The adherent layer uses thickness as 2~3mm's
Non-woven fabrics.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108384517A (en) * | 2018-02-22 | 2018-08-10 | 四川艾施派尔新材料科技有限公司 | A kind of nanometer of ice bag and preparation method thereof |
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