CN102827441B - Cooling gel sheet - Google Patents
Cooling gel sheet Download PDFInfo
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- CN102827441B CN102827441B CN201210222734.5A CN201210222734A CN102827441B CN 102827441 B CN102827441 B CN 102827441B CN 201210222734 A CN201210222734 A CN 201210222734A CN 102827441 B CN102827441 B CN 102827441B
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- polyvinyl alcohol
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- reducing paste
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Abstract
The invention discloses a cooling gel sheet which comprises the following components in percentage by weight: 1 to 3% of acrylic acid, 0.05 to 0.3% of non-ionic cellulose ether with thermosensitivity, 3 to 6% of polyving akohol, 0.3 to 1% of pregelatinized starch, 0.05 to 0.3% of cross-linking agent, 0.05 to 0.3% of initiator, and the balance of water. The cooling gel sheet disclosed by the invention has quickly responding thermosensitivity, so an effect of quickly cooling can be achieved. The cooling gel sheet is safe and reliable, and plays a function by completely depending on physical cooling.
Description
Technical field
The invention belongs to medicochemistry product compositions field, relate in particular to a kind of temperature-reducing paste.
Background technology
Clinical conventional cooling measure mainly contains two kinds, and one is Physical temperature-lowering, and one is drug cooling.Any cool-down method of concrete application, should decide according to patient's age, physique and the degree of heat.Drug cooling has the advantages such as successful, using method be simple, in clinical, conventional antipyretic and analgesic has acetylsalicylic acid (acetylsalicylic acid), Paracetamol (paracetamol), INDOMETHACIN (indomethacin), Ibuprofen BP/EP etc. at present, but liver kidney and the gastral infringement of these Side effects of pharmaceutical drugs to infant is surprising or irreversible, and drug cooling has a lot of contraindications, as: there is the patient of antipyretic allergies should forbid febrifugee; Also should be prudent when the patient of allergic constitution applies febrifugee; Serious liver damage, vitamin K deficiency person, haemophiliac and have the patient of asthma history should avoid using acetylsalicylic acid, in case hemorrhage and bring out asthma; Pyramidon can cause agranulocytosis, and period in a medicine is as found granulocytopenia drug withdrawal immediately.So febrifugee can not long-term taking, otherwise can cause acute and chronic poisoning.General body temperature at 39 DEG C below preferably without drug cooling.
Traditional physical cooling method has: 1. watch-keeping cubicle warm therapy; 2. 34 ~ 35 DEG C of warm water or 30 DEG C of 25% ~ 30% ethanol songe bath method; 3. ice compress method; 4. icy salt solution bowel lavage or administration by gavage; 5. hypothermic blanket continues falling temperature method; 6. vein falling temperature method etc.Above cool-down method has been widely used in clinical by doctor, played different cooling-down effects.But above method is more loaded down with trivial details, what have also can cause toxic side effects.
Novel physical cooling method mainly refers to high-molecular gel temperature-reducing paste falling temperature method, its cool principle is by the evaporation of moisture in its main component hydrogel, take away human heat, thereby reach the object of local cooling, the cooling-down effect of product depends primarily on the moisture content in hydrogel.This series products does not need refrigerating apparatus, does not need setup time, when use, unpacks, and is affixed on forehead or other positions by viscosity own, uses more for convenience.[Chinese invention patent 201020583841.7] provides a kind of cooling paster of measurable temperature, is made up of non-woven fabrics, hydrogel and plastics film, it is characterized in that hydrogel is divided into different temperature zones, has temperature-sensitive colour changing thermal indicutor sheet in each temperature zone.But current existing temperature-reducing paste product exists many defects, as generally shorter in temperature fall time, is generally about 2-3 hour, and only for once using, virtually increase patient's use cost; Existing temperature-reducing paste is many by adding the traditional Chinese medicine ingredients such as peppermint, borneol to carry out auxiliary temperature-reducing; this class traditional Chinese medicine ingredients is by stimulating human nerve; make people produce refrigerant sensation; but really do not play the effect that reduces temperature protection brain cell; and these pharmaceutical cpds have larger hormesis to eye and wound, when use, easily make troubles to patient.[Chinese invention patent 201020239963.4] relates to a kind of reusable bacterial cellulose hydrogel temperature-reducing plaster, comprises macromolecule membrane layer and bacteria cellulose aquagel functional layer.[Chinese invention patent 200720192944.9] relates to a kind of physical cooling paste, comprise nonwoven layer, plastic film layers and hydrophilic high molecular material functional layer, it is characterized in that being mixed with in hydrophilic high molecular material functional layer peppermint and/or borneol natural phant elite.
Therefore, have that a kind of production technique is simple, no side effects, easy to use, the demand of temperature-reducing paste product fast of lowering the temperature.
In addition, according to water-soluble cooling paster because of water content high, can take away rapidly human heat's feature, its Application Areas, also in continuous expansion, has been applied to alleviating pain, refreshment, has relaxed one's muscles, improved the fields such as the medicine such as sleep, skin moisture-keeping beauty treatment, sports goods, beauty treatment, articles for daily use.
Summary of the invention
The object of the invention is to propose a kind of temperature-reducing paste of temperature with high efficiency easily and fast.
The present invention adopts following technical scheme to achieve these goals:
A kind of temperature-reducing paste, is characterized in that: the component by following weight percent forms:
Vinylformic acid 1-3%
There is the non-ionic celluloses ether 0.05-0.3% of Thermo-sensitive
Polyvinyl alcohol 3-6%
Pregelatinized Starch 0.3-1%
Linking agent 0.05-0.3%
Initiator 0.05-0.3%
Water surplus;
Preparation method comprises the following steps:
(1) add by mass percentage initiator to having in the non-ionic celluloses ether of Thermo-sensitive and the aqueous solution that vinylformic acid mixes by mass percentage, under nitrogen protection, at 35-40 DEG C, react after 8-12 minute, add by mass percentage linking agent stirring reaction after 5-6 hour, the concentrated solution of Mierocrystalline cellulose/acrylate/nano gel;
(2) clear soln that is mixed with soluble in water under microwave-assisted by polyvinyl alcohol and pregelatinized Starch, then add wherein the concentrated solution of Mierocrystalline cellulose/acrylate/nano gel, pours into cryogenic freezing 2-3 hour after mould, and repeated freezing 2-5 time, to obtain final product.
Described a kind of temperature-reducing paste, is characterized in that: described linking agent refers to the one in N ' N-methylene-bisacrylamide, diacetyl oxide, MALEIC ANHYDRIDE.
Described a kind of temperature-reducing paste, is characterized in that: described initiator refers to Potassium Persulphate or ammonium persulphate.
Described a kind of temperature-reducing paste, is characterized in that: the described non-ionic celluloses ether with Thermo-sensitive refers to the one in HPMC ether, hydroxypropylcelluloether ether, methyl cellulose ether.
Described a kind of temperature-reducing paste, is characterized in that: the described polyvinyl alcohol polymerization degree is 1350-2050.
Described a kind of temperature-reducing paste, is characterized in that: the temperature of described cryogenic freezing operation is not for higher than-12 DEG C.
Described a kind of temperature-reducing paste, is characterized in that: described microwave-assisted operation refers to soluble in water to polyvinyl alcohol and pregelatinized Starch, then puts into microwave reactor reaction 5-10 second.
Principle of the present invention is:
Polyvinyl alcohol hydrogel of the present invention has good biocompatibility, can not cause any stimulation or sense of discomfort to human body skin, is applicable to children's and uses.Polyvinyl alcohol can replace with dextran, has equally good swelling property and water-retentivity.
Pregelatinized Starch of the present invention is used for improving molding time and the shaping strength of polyvinyl alcohol hydrogel.
Temperature-reducing paste of the present invention can contain flavouring agent to bring the various fragrance of a flower or fruit smell to product, makes child patient be easy to receive treatment.
This product is not limited to as Physical temperature-lowering product, can be used for equally alleviating pain, refreshment, relax one's muscles, improve sleep, etc. the fields such as medicine, sports goods, articles for daily use.
Beneficial effect of the present invention: advantage of the present invention is, the lower critical solution temperature with HPMC/polyacrylic acid composite Nano gel of temperature sensitivity is 38 DEG C, and when children's's forehead temperature is during higher than 38 DEG C, gel shrinks, moisture in hydrogel evaporates, and takes away the heat of human body; When temperature is during lower than 38 DEG C, gel water suction is swelling once again, thereby realizes reusable.The present invention has the temperature sensitivity of quick response, can reach the effect of fast cooling.This product safety is reliable, relies on Physical temperature-lowering completely.
Brief description of the drawings
Fig. 1 is the sign collection of illustrative plates of the present invention under transmission electron microscope;
Fig. 2 is for testing cooling-down effect figure of the present invention by constant temperature heating plate simulation human body temperature;
Fig. 3 is the cooling-down effect comparison diagram of ordinary gel paster and paster of the present invention.
Embodiment
Non-limiting examples is described below:
Embodiment 1, get 0.4 g HPMC and 8.0 g vinylformic acid are dissolved in 90 ml distilled water, then add 0.35 g Potassium Persulphate, be filled with nitrogen, temperature rises to 38 DEG C, preheating adds 0.35 g N ' N-methylene-bisacrylamide after 10 minutes, stirring reaction must be received the concentrated solution of gel for 5 hours; Then get 4.5 g polyvinyl alcohol (polymerization degree is 1950) and 0.65 g pregelatinized Starch is dissolved in 75 ml distilled water under microwave assistant, after dissolving completely, the gel concentrate of receiving of getting 25 ml adds in this solution, after slightly cold, pour into and in mould, put into refrigerated tank (15 DEG C) and thaw after freezing 2.5 hours, circulate 2 times, must be containing receiving the hydrogel temperature-reducing plaster of gel.
Fig. 2 is cooling-down effect figure---with constant temperature heating plate simulation human body temperature test cooling-down effect, temperature-reducing paste is placed in respectively on the constant temperature heating plate of 37 DEG C, 38 DEG C, 39 DEG C, within every 10 minutes, measure respectively the temperature of the temperature-constant plate (being temperature-reducing paste and temperature-constant plate contact surface) under temperature-reducing paste, test constantly 180 min.As shown in Figure 2, X-coordinate is the attaching time, and ordinate zou is measured temperature.From figure, can draw, paste while being 38 DEG C of left and right by front temperature-constant plate temperature, paste with obviously (33.5 DEG C of left and right) of temperature decline after 10 min, paste with 34.5 DEG C of left and right of local temperature after 30 min, subsides weaken gradually with cooling-down effect after 1 h, 35 DEG C of left and right of local temperature, within 3 hours working lipe, the temperature of temperature-constant plate is less than 38 DEG C of beginning always, illustrates that temperature-reducing paste plays cooling effect always, compare with other two groups, cooling-down effect is obvious.
Fig. 3 is ordinary gel paster and containing receiving the cooling-down effect figure of cooling paster of gel, can find out significantly that ordinary gel paster does not have cooling-down effect substantially from figure.
Embodiment 2, get 0.45 g HPMC and 7.2 g vinylformic acid are dissolved in 90 ml distilled water, then add 0.4 g Potassium Persulphate, be filled with nitrogen, temperature rises to 38 DEG C, preheating adds 0.4 g N ' N-methylene-bisacrylamide after 10 minutes, stirring reaction must be received the concentrated solution of gel for 6 hours; Then get 4.8 g polyvinyl alcohol (polymerization degree is 1800) and 0.8 g pregelatinized Starch is dissolved in 70 ml distilled water under microwave assistant, after dissolving completely, the gel concentrate of receiving of getting 25 ml adds in this solution, after slightly cold, pour into and in mould, put into refrigerated tank (20 DEG C) and thaw after freezing two hours, circulate 2 times, must be containing receiving the hydrogel temperature-reducing plaster of gel.
Embodiment 3, get 0.4 g HPMC, 0.35 g MALEIC ANHYDRIDE and 8.0 g vinylformic acid mixing solutionss and be dissolved in 90 ml distilled water, then add 0.35 g ammonium persulphate, be filled with nitrogen, temperature rises to 38 DEG C, and stirring reaction must be received the concentrated solution of gel for 5 hours; Then get 5 g polyvinyl alcohol (polymerization degree is 1750) and 0.6 g pregelatinized Starch is dissolved in 75 ml distilled water under microwave assistant, after dissolving completely, the gel concentrate of receiving of getting 25 ml adds in this solution, after slightly cold, pour into and in mould, put into refrigerated tank (12 DEG C) and thaw after freezing 3 hours, circulate 3 times, must be containing receiving the hydrogel temperature-reducing plaster of gel.
Embodiment 4, get 0.4 g HPMC and 6.0 g vinylformic acid are dissolved in 90 ml distilled water, then add 0.4 g Potassium Persulphate, be filled with nitrogen, temperature rises to 38 DEG C, preheating adds 0.4 g N ' N-methylene-bisacrylamide after 10 minutes, stirring reaction must be received the concentrated solution of gel for 5 hours; Then get 4.5 g polyvinyl alcohol (polymerization degree is 1950) and 0.6 g pregelatinized Starch is dissolved in 75 ml distilled water under microwave assistant, after dissolving completely, the gel concentrate of receiving of getting 25 ml adds in this solution, after slightly cold, pour into and in mould, put into refrigerated tank (15 DEG C) and thaw after freezing 2.5 hours, circulate 2 times, must be containing receiving the hydrogel temperature-reducing plaster of gel.
Embodiment 5, get 0.38 g HPMC and 6.8 g vinylformic acid are dissolved in 90 ml distilled water, then add 0.35 g Potassium Persulphate, be filled with nitrogen, temperature rises to 38 DEG C, preheating adds 0.35 g N ' N-methylene-bisacrylamide after 10 minutes, stirring reaction must be received the concentrated solution of gel for 5 hours; Then get 5 g polyvinyl alcohol (polymerization degree is 1850) and 0.65 g pregelatinized Starch is dissolved in 75 ml distilled water under microwave assistant, after dissolving completely, the gel concentrate of receiving of getting 25 ml adds in this solution, after slightly cold, pour into and in mould, put into refrigerated tank (20 DEG C) and thaw after freezing 2 hours, circulate 2 times, must be containing receiving the hydrogel temperature-reducing plaster of gel.
Embodiment 6, a kind of temperature-reducing paste, be made up of the component of following weight percent:
Vinylformic acid 1%
There is the non-ionic celluloses ether 0.3% of Thermo-sensitive
Polyvinyl alcohol 3%
Pregelatinized Starch 1%
Linking agent 0.3%
Initiator 0.3%
Water surplus;
Preparation method comprises the following steps:
(1) add by mass percentage initiator to having in the non-ionic celluloses ether of Thermo-sensitive and the aqueous solution that vinylformic acid mixes by mass percentage, under nitrogen protection, at 40 DEG C, react after 10 minutes, add by mass percentage linking agent stirring reaction after 5 hours, the concentrated solution of Mierocrystalline cellulose/acrylate/nano gel;
(2) clear soln that is mixed with soluble in water under microwave-assisted by polyvinyl alcohol and pregelatinized Starch, then add wherein the concentrated solution of Mierocrystalline cellulose/acrylate/nano gel, pours into after mould cryogenic freezing 2 hours, and freeze cycle 2 times, to obtain final product.
Described linking agent refers to diacetyl oxide.
Described initiator refers to Potassium Persulphate.
The described non-ionic celluloses ether with Thermo-sensitive refers to methyl cellulose ether.
The described polyvinyl alcohol polymerization degree is 2050.
The temperature of described cryogenic freezing operation is-18 DEG C.
Described microwave-assisted operation refers to soluble in water to polyvinyl alcohol and pregelatinized Starch, then puts into microwave reactor reaction 10 seconds.
Claims (6)
1. a temperature-reducing paste, is characterized in that: the component by following weight percent forms:
Vinylformic acid 1-3%
There is the non-ionic celluloses ether 0.05-0.3% of Thermo-sensitive
Polyvinyl alcohol 3-6%
Pregelatinized Starch 0.3-1%
Linking agent 0.05-0.3%
Initiator 0.05-0.3%
Water surplus;
Preparation method comprises the following steps:
(1) add by mass percentage initiator to having in the non-ionic celluloses ether of Thermo-sensitive and the aqueous solution that vinylformic acid mixes by mass percentage, under nitrogen protection, at 35-40 DEG C, react after 8-12 minute, add by mass percentage linking agent stirring reaction after 5-6 hour, the concentrated solution of Mierocrystalline cellulose/acrylate/nano gel;
(2) clear soln that is mixed with soluble in water under microwave-assisted by polyvinyl alcohol and pregelatinized Starch, then add wherein the concentrated solution of Mierocrystalline cellulose/acrylate/nano gel, pours into cryogenic freezing 2-3 hour after mould, and repeated freezing 2-5 time, to obtain final product;
The described polyvinyl alcohol polymerization degree is 1350-2050.
2. a kind of temperature-reducing paste according to claim 1, is characterized in that: described linking agent refers to the one in N ' N-methylene-bisacrylamide, diacetyl oxide, MALEIC ANHYDRIDE.
3. a kind of temperature-reducing paste according to claim 1, is characterized in that: described initiator refers to Potassium Persulphate or ammonium persulphate.
4. a kind of temperature-reducing paste according to claim 1, is characterized in that: the described non-ionic celluloses ether with Thermo-sensitive refers to the one in HPMC ether, hydroxypropylcelluloether ether, methyl cellulose ether.
5. a kind of temperature-reducing paste according to claim 1, is characterized in that: the temperature of described cryogenic freezing operation is not for higher than-12 DEG C.
6. a kind of temperature-reducing paste according to claim 1, is characterized in that: described microwave-assisted operation refers to soluble in water to polyvinyl alcohol and pregelatinized Starch, then puts into microwave reactor reaction 5-10 second.
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CN201210222734.5A CN102827441B (en) | 2012-06-30 | 2012-06-30 | Cooling gel sheet |
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CN201210222734.5A CN102827441B (en) | 2012-06-30 | 2012-06-30 | Cooling gel sheet |
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CN108341975A (en) * | 2017-12-29 | 2018-07-31 | 佛山市锦彤企业管理有限公司 | A kind of high withstand voltage intensity antimicrobial macromolecule hydrogel |
CN112401355A (en) * | 2020-10-22 | 2021-02-26 | 浙江大学医学院附属妇产科医院 | Temperature sensing and temperature regulation's barrier gown |
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JPS5930881A (en) * | 1982-08-13 | 1984-02-18 | Nippon Oil Co Ltd | Manufacture of low-temperature insulating gel |
CN101095634A (en) * | 2007-07-12 | 2008-01-02 | 长春吉原生物科技有限公司 | Temperature-reducing paste and method of manufacturing the same |
CN102440979A (en) * | 2010-09-30 | 2012-05-09 | 迪特克(济源)绿色生物科技有限公司 | Cellulose derivative composite film and preparation method thereof |
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