CN105147726A - Medical application preventing and curing phlebitis and preparing method thereof - Google Patents
Medical application preventing and curing phlebitis and preparing method thereof Download PDFInfo
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- CN105147726A CN105147726A CN201510623584.2A CN201510623584A CN105147726A CN 105147726 A CN105147726 A CN 105147726A CN 201510623584 A CN201510623584 A CN 201510623584A CN 105147726 A CN105147726 A CN 105147726A
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- phlebitis
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- alginate
- magnesium sulfate
- cetirizine
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Abstract
The invention discloses medical application preventing and curing phlebitis and a preparing method thereof. The application is prepared from, by weight, 3-10% of alginate, 3-4% of aloe pectin, 35-55% of magnesium sulfate, 1-2% of cetirizine, 1-2% of clarityne, 3-7% of wet storage agent, 1-3% of sodium tetraborate decahydrate and the balance deionized water. The multiple components in the application have the synergistic effect, inflammatory cells are restrained from gathering on the inflammation part, inflammatory responses are reduced, and the inflammation diminishing and swell stopping efficiency is high; the application is used for maintaining a PICC indwelling catheter, the occurrence rate of mechanical phlebitis is obviously reduced, the effect of treating the phlebitis is remarkable, onset time is short, and the swelling subsidence rate is high; the application has the effects of expanding the blood vessel and promoting blood circulation. The application is convenient to use and easy to operate, and relieves pain of patients.
Description
Technical field
The present invention relates to field of medical article technology, be specifically related to one and prevent and treat phlebitis medical application and preparation method thereof.
Background technology
Extensive through periphery venipuncture central vein catheter (PICC) clinical practice, because its indwelling catheter time is long, safety, be adapted to chemotherapy, the outer intravenous nutrition of intestinal, long-term infusion, major operation and critical patient, the workload of nurse is decreased while effectively reaching therapeutic effect, for patient provides a Silent Neuritis infusion channel, serve the effect of peripheral blood vessel puncture, central vein treatment.But put some complication occurred in pipe process also to can not be ignored.Bibliographical information, after PICC, the incidence rate of mechanical phlebitis is 17.6%-25.0%, often to betide after paracentesis 48 ~ 72 hours.At present, commonly use hot towel hot compress clinically or treat phlebitis with 50% magnesium sulfate gauze soak, but there is a lot of problem, as frequent in changed towel, temperature is non-constant, and easily catching a cold causes vasoconstriction, and nursing work load is large; Ingredient is all more single, and cause its onset time slow, patient often needs continuous soak could eliminate subcutaneous edema in several days, the clinical needs of the inpatient carrying out venous transfusion for a long time that can not satisfy the demand.
Summary of the invention
For the deficiencies in the prior art, the invention provides fast, the antiinflammatory of a kind of effective, onset time only swollen efficiency high, can blood vessel dilating, blood circulation promoting prevent and treat phlebitis medical application and preparation method thereof.
For realizing above object, the present invention is achieved by the following technical programs:
One prevents and treats phlebitis medical application, comprises the raw material of following weight portion: alginate 3 ~ 10%, aloe pectin 3 ~ 4%, magnesium sulfate 35 ~ 55%, cetirizine 1 ~ 2%, loratadine 1 ~ 2%, wetting agent 3 ~ 7%, sodium tetraborate decahydrate 1 ~ 3%, surplus are deionized water.
Preferably, prevent and treat phlebitis medical application, comprise the raw material of following weight portion: alginate 3%, aloe pectin 3%, magnesium sulfate 55%, cetirizine 1%, loratadine 1%, wetting agent 3%, sodium tetraborate decahydrate 1%, surplus are deionized water.Comprise following raw material by weight
Preferably, prevent and treat phlebitis medical application, comprise the raw material of following weight portion: alginate 10%, aloe pectin 4%, magnesium sulfate 35%, cetirizine 2%, loratadine 2%, wetting agent 7%, sodium tetraborate decahydrate 3%, surplus are deionized water.
Preferably, prevent and treat phlebitis medical application, comprise the raw material of following weight portion: alginate 3 ~ 10%, aloe pectin 3 ~ 4%, magnesium sulfate 35 ~ 55%, cetirizine 1 ~ 2%, loratadine 1 ~ 2%, wetting agent 3 ~ 7%, sodium tetraborate decahydrate 1 ~ 3%, surplus are deionized water.
Preferably, described wetting agent comprises any one in glycerol, Polyethylene Glycol and propylene glycol.
Prevent and treat a preparation method for phlebitis medical application, comprise the following steps:
1), by alginate, aloe pectin, magnesium sulfate, cetirizine, loratadine, wetting agent, sodium tetraborate decahydrate be made into aqueous solution with deionized water dissolving respectively, then obtain mixed solution by even for all aqueous solution;
2), under 10,000 grades of clean working conditions, by the medical carrier through sterilization treatment, put into container, add step 1) in the medicinal liquid that is up to the standards soak 60 ~ 90min, to load in the plastic bag of the high pressure resistant high temperature of sterilization treatment and to seal;
3), by step 2) the middle plastic bag 100 DEG C of steam sterilization 40 ~ 50min sealed, make phlebitis and apply ointment or plaster.
In the present invention, each component has following effect:
Magnesium sulfate has high osmosis effect, can eliminate rapidly local organization inflammatory edema, having the calm spasm with improving blood capillary and thin vessels, eliminating myxedema, and expansion local vascular, strengthens vascular circulation, improve blood vessel inner skin cell function.
Sodium alginate hydrophilic is strong, can dissolve, form the uniform solution of very thickness in cold water and warm water, and the aqueous solution formed has flexibility, homogeneity and other good characteristics that other analog are difficult to obtain.
Aloe pectin energy blood vessel dilating, blood circulation promoting, has bactericidal antiphlogistic, prevents allergy, decomposes the dead histiocyte infected, promotes effect of cell proliferation regeneration, and in addition, aloe pectin also has the effect of good moisturizing, analgesia and hemostasis.
Sodium tetraborate decahydrate is a kind of good antiinflammatory antiseptic, this medicine stable chemical performance simultaneously, there is the anticorrosion analgesic effect of obvious inhibiting bacteria and diminishing inflammation combine soak with magnesium sulfate and can effective percutaneous infiltration and absorption make it eliminate edema, the analgesic effect that diminishes inflammation is rapider, thus alleviates the inflammatory reaction such as redness, burning pain.
Cetirizine, loratadine have certain antianaphylactic effect, compared with chlorphenamine, diphenhydramine, side effect is little, and chlorphenamine, diphenhydramine have obvious sedation and nervus centralis untoward reaction, side effect is large, and the low person of hepatic and renal function and gerontal patient should be cautious use of.
Beneficial effect: in the present invention, sodium alginate is dissolved in water and forms the uniform solution of thickness, can magnesium sulfate mixed solution stable uniform be adhered on medical carrier, and various ingredients synergism, inhibit inflammatory cell in the gathering of inflammation part, reduce inflammation reaction, aloe pectin also has analgesia, blood vessel dilating, the effect of blood circulation promoting.Of the present invention apply ointment or plaster for PICC put pipe safeguard, the incidence rate of mechanical phlebitis obviously reduces, for phlebitis treatment also have certain effect, and onset time is fast, only swollen efficiency is high in antiinflammatory, of the present inventionly apply ointment or plaster easy to use, simple to operate, decrease the misery of patient.
Detailed description of the invention
For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1:
One prevents and treats phlebitis medical application, comprises the raw material of following weight portion: alginate 3%, aloe pectin 3%, magnesium sulfate 55%, cetirizine 1%, loratadine 1%, glycerol 3%, sodium tetraborate decahydrate 1%, surplus are deionized water.
Prevent and treat the preparation method of phlebitis medical application, comprise the following steps:
1), by alginate, aloe pectin, magnesium sulfate, cetirizine, loratadine, wetting agent, sodium tetraborate decahydrate be made into aqueous solution with deionized water dissolving respectively, then obtain mixed solution by even for all aqueous solution;
2), under 10,000 grades of clean working conditions, by the medical carrier through sterilization treatment, put into container, add step 1) in the medicinal liquid that is up to the standards soak 60 ~ 90min, to load in the plastic bag of the high pressure resistant high temperature of sterilization treatment and to seal;
3), by step 2) the middle plastic bag 100 DEG C of steam sterilization 40 ~ 50min sealed, make phlebitis and apply ointment or plaster.
Embodiment 2:
One prevents and treats phlebitis medical application, comprises the raw material of following weight portion: alginate 10%, aloe pectin 4%, magnesium sulfate 35%, cetirizine 2%, loratadine 2%, Polyethylene Glycol 7%, sodium tetraborate decahydrate 3%, surplus are deionized water.
Prevent and treat the preparation method of phlebitis medical application, comprise the following steps:
1), by alginate, aloe pectin, magnesium sulfate, cetirizine, loratadine, wetting agent, sodium tetraborate decahydrate be made into aqueous solution with deionized water dissolving respectively, then obtain mixed solution by even for all aqueous solution;
2), under 10,000 grades of clean working conditions, by the medical carrier through sterilization treatment, put into container, add step 1) in the medicinal liquid that is up to the standards soak 60 ~ 90min, to load in the plastic bag of the high pressure resistant high temperature of sterilization treatment and to seal;
3), by step 2) the middle plastic bag 100 DEG C of steam sterilization 40 ~ 50min sealed, make phlebitis and apply ointment or plaster.
The patient selecting certain hospital to put pipe because of PICC is because of restlessness or PeV puncture position is improper causes liquid in venous transfusion process to ooze out and exosmose to subcutaneous patient 100 example that swells and ache, man 50 example, female 50 example, the age 25-70 year.Be divided into observation group 50 example at random, matched group 50 example.Two groups of sexes, age, state of an illness compare, and no significant difference, has comparability.
Therapeutic Method: will apply ointment or plaster and be placed in limbs pain swelling position soak 30min, one day 3 times, observation group adopts of the present invention applying ointment or plaster to carry out the treatment of a course for the treatment of (10 days), and matched group adopts 50% Adlerika to carry out the soak treatment of a course for the treatment of (10 days).
Therapeutic outcome: in observation group 50 example after the course for the treatment of, cure completely have 33 example, pain have significantly alleviate have 17 example.
In matched group 50 example after the course for the treatment of, that cures completely has 18 people, pain have significantly alleviate have 26 example, 6 people feel without any effect.
Tradition Adlerika effective percentage of applying ointment or plaster is 88%, and the present invention prevents and treats phlebitis and applies ointment or plaster total effective rate up to 100%, compares, and the present invention's curative effect of applying ointment or plaster has marked improvement.
Embodiment 3:
One prevents and treats phlebitis medical application, comprises the raw material of following weight portion: alginate 3 ~ 10%, aloe pectin 3 ~ 4%, magnesium sulfate 35 ~ 55%, cetirizine 1 ~ 2%, loratadine 1 ~ 2%, propylene glycol 3 ~ 7%, sodium tetraborate decahydrate 1 ~ 3%, surplus are deionized water.
Prevent and treat the preparation method of phlebitis medical application, comprise the following steps:
1), by alginate, aloe pectin, magnesium sulfate, cetirizine, loratadine, wetting agent, sodium tetraborate decahydrate be made into aqueous solution with deionized water dissolving respectively, then obtain mixed solution by even for all aqueous solution;
2), under 10,000 grades of clean working conditions, by the medical carrier through sterilization treatment, put into container, add step 1) in the medicinal liquid that is up to the standards soak 60 ~ 90min, to load in the plastic bag of the high pressure resistant high temperature of sterilization treatment and to seal;
3), by step 2) the middle plastic bag 100 DEG C of steam sterilization 40 ~ 50min sealed, make phlebitis and apply ointment or plaster.
It should be noted that, in this article, the such as relational terms of first and second grades and so on is only used for an entity or operation to separate with another entity or operating space, and not necessarily requires or imply the relation that there is any this reality between these entities or operation or sequentially.And, term " comprises ", " comprising " or its any other variant are intended to contain comprising of nonexcludability, thus make to comprise the process of a series of key element, method, article or equipment and not only comprise those key elements, but also comprise other key elements clearly do not listed, or also comprise by the intrinsic key element of this process, method, article or equipment.When not more restrictions, the key element limited by statement " comprising ... ", and be not precluded within process, method, article or the equipment comprising described key element and also there is other identical element.
Above embodiment only in order to technical scheme of the present invention to be described, is not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (6)
1. prevent and treat phlebitis medical application for one kind, it is characterized in that, comprise the raw material of following weight portion: alginate 3 ~ 10%, aloe pectin 3 ~ 4%, magnesium sulfate 35 ~ 55%, cetirizine 1 ~ 2%, loratadine 1 ~ 2%, wetting agent 3 ~ 7%, sodium tetraborate decahydrate 1 ~ 3%, surplus are deionized water.
2. one as claimed in claim 1 prevents and treats phlebitis medical application, it is characterized in that, comprise the raw material of following weight portion: alginate 3%, aloe pectin 3%, magnesium sulfate 55%, cetirizine 1%, loratadine 1%, wetting agent 3%, sodium tetraborate decahydrate 1%, surplus are deionized water.Comprise following raw material by weight.
3. one as claimed in claim 1 prevents and treats phlebitis medical application, it is characterized in that, comprise the raw material of following weight portion: alginate 10%, aloe pectin 4%, magnesium sulfate 35%, cetirizine 2%, loratadine 2%, wetting agent 7%, sodium tetraborate decahydrate 3%, surplus are deionized water.
4. one as claimed in claim 1 prevents and treats phlebitis medical application, it is characterized in that, comprise the raw material of following weight portion: alginate 3 ~ 10%, aloe pectin 3 ~ 4%, magnesium sulfate 35 ~ 55%, cetirizine 1 ~ 2%, loratadine 1 ~ 2%, wetting agent 3 ~ 7%, sodium tetraborate decahydrate 1 ~ 3%, surplus are deionized water.
5. the one as described in claim 1-4 prevents and treats phlebitis medical application, it is characterized in that, described wetting agent comprises any one in glycerol, Polyethylene Glycol and propylene glycol.
6. the preparation method of preventing and treating phlebitis medical application as described in as arbitrary in Claims 1 to 5, is characterized in that, comprise the following steps:
1), by alginate, aloe pectin, magnesium sulfate, cetirizine, loratadine, wetting agent, sodium tetraborate decahydrate be made into aqueous solution with deionized water dissolving respectively, then obtain mixed solution by even for all aqueous solution;
2), under 10,000 grades of clean working conditions, by the medical carrier through sterilization treatment, put into container, add step 1) in the medicinal liquid that is up to the standards soak 60 ~ 90min, to load in the plastic bag of the high pressure resistant high temperature of sterilization treatment and to seal;
3), by step 2) the middle plastic bag 100 DEG C of steam sterilization 40 ~ 50min sealed, make phlebitis and apply ointment or plaster.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510623584.2A CN105147726A (en) | 2015-09-25 | 2015-09-25 | Medical application preventing and curing phlebitis and preparing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510623584.2A CN105147726A (en) | 2015-09-25 | 2015-09-25 | Medical application preventing and curing phlebitis and preparing method thereof |
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| CN105147726A true CN105147726A (en) | 2015-12-16 |
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| CN201510623584.2A Pending CN105147726A (en) | 2015-09-25 | 2015-09-25 | Medical application preventing and curing phlebitis and preparing method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769935A (en) * | 2016-04-05 | 2016-07-20 | 北京世纪博康医药科技有限公司 | Kelp composition |
| CN108671120A (en) * | 2018-07-13 | 2018-10-19 | 重庆市中医院 | A kind of compound Chinese aloe breast and preparation method thereof |
| CN115282234A (en) * | 2021-11-26 | 2022-11-04 | 李娜 | External preparation for relieving swelling and treating furuncle and carbuncle |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614324A (en) * | 2012-04-25 | 2012-08-01 | 刘永芳 | Chinese medicinal synthetic preparation for assisting western medicines in treating phlebophlogosis |
| CN103127168A (en) * | 2013-03-18 | 2013-06-05 | 贾国平 | Hydropathic compress paste containing magnesium sulfate as well as preparation method and application of paste |
| CN103251777A (en) * | 2012-02-22 | 2013-08-21 | 李汝芬 | Application of aloe |
-
2015
- 2015-09-25 CN CN201510623584.2A patent/CN105147726A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251777A (en) * | 2012-02-22 | 2013-08-21 | 李汝芬 | Application of aloe |
| CN102614324A (en) * | 2012-04-25 | 2012-08-01 | 刘永芳 | Chinese medicinal synthetic preparation for assisting western medicines in treating phlebophlogosis |
| CN103127168A (en) * | 2013-03-18 | 2013-06-05 | 贾国平 | Hydropathic compress paste containing magnesium sulfate as well as preparation method and application of paste |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769935A (en) * | 2016-04-05 | 2016-07-20 | 北京世纪博康医药科技有限公司 | Kelp composition |
| CN108671120A (en) * | 2018-07-13 | 2018-10-19 | 重庆市中医院 | A kind of compound Chinese aloe breast and preparation method thereof |
| CN108671120B (en) * | 2018-07-13 | 2021-04-06 | 重庆市中医院 | Compound aloe milk and preparation method thereof |
| CN115282234A (en) * | 2021-11-26 | 2022-11-04 | 李娜 | External preparation for relieving swelling and treating furuncle and carbuncle |
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Application publication date: 20151216 |