CN103127168A - Hydropathic compress paste containing magnesium sulfate as well as preparation method and application of paste - Google Patents
Hydropathic compress paste containing magnesium sulfate as well as preparation method and application of paste Download PDFInfo
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- CN103127168A CN103127168A CN2013100848800A CN201310084880A CN103127168A CN 103127168 A CN103127168 A CN 103127168A CN 2013100848800 A CN2013100848800 A CN 2013100848800A CN 201310084880 A CN201310084880 A CN 201310084880A CN 103127168 A CN103127168 A CN 103127168A
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Abstract
The invention discloses a hydropathic compress paste containing magnesium sulfate and a preparation method thereof. The hydropathic compress paste consists of 20%-50% of magnesium sulfate, 0.1%-5% of borax and the balance of purified water and a medical carrier. The preparation method comprises the following steps of: producing the medical carrier into a sheet, using magnesium sulfate and borax solution to soaking and fully wetting the sheet by using magnesium sulfate and borax solution, putting the sheet into a sealing packaging bag, sealing, packaging, sterilizing through cobalt-60 irradiation, and thus preparing the hydropathic compress paste containing magnesium sulfate. The hydropathic compress paste containing magnesium sulfate can effectively prevent phlebitis and has a good effect in nursing and treating swelling pain and inflammation caused by edema of local subcutaneous tissues when patients are intravenously infused with chemotherapeutics, so that the pain of paints is relieved, and the life quality of the patients is improved.
Description
Technical field
The invention belongs to field of medical technology, relate to swelling pain that the prophylactic treatment local subcutaneous tissue occurs that edema produces and the medical accessory of inflammation, say more specifically a kind of magnesium sulfate dressing sheet and preparation method thereof and application that swollen pain relieving effect is gone in antiinflammatory that have.
Background technology
Once sick just requirement of many personages infused.Generally all think that the infusion treatment means are direct, instant effect, but do not know because the reason of technology can be brought the risk of some transfusions and hidden danger into human body, thereby cause the acute reaction of transfusion inevitably when infusing, or the potential hazard that causes transfusion to cause.For many years, in venous transfusion, because negligent supervision causes non-aggressive, corrosive medicine or solution to enter surrounding tissue, cause and ooze out and exosmose, cause the event that swelling pain appears in local subcutaneous tissue and happen occasionally.Have again in recent years, malignant tumor patient is used chemotherapeutic often to cause Superficial veins inflammation in various degree, bring very large misery to patient, be used for the treatment of clinically the method that the local subcutaneous tissue swelling pain is commonly used at present and treat with the soak sheet soak of magnesium sulfate solution and medical carrier composition.The inventor is engaged in soak treatment technology research work for many years, in succession applied for the patents such as " sterilize sal amarum wet sheet ", " magnesium sulfate application patch ", " magnesium sulfate dry tablet " in 2007-2012, emphasis at that time is in order to solve the agricultural technology problem of magnesium sulfate dressing sheet.The production of magnesium sulfate dressing sheet is had relatively high expectations to medical carrier and packaging material, as the quality of packaging material once go wrong can produce leakage, the situation such as mouldy causes heavy losses.In addition, it is higher that the plant-scale equipment belongs to the special equipment cost, and production process will expend mass energy, and production cost is higher.But, along with deepening continuously of research, the inventor finds that the product that magnesium sulfate dressing sheet original production process and method are produced easily goes mouldy in storage, is difficult for long-time the storage in practice.In addition, because the soak sheet is to adopt high temperature sterilize, and product needed producing cost under 10,000 grades of clean environments is higher and operation is also complicated.For this reason, the inventor is on the basis of original experimentation: further studied production technology and preparation method that a kind of magnesium sulfate dressing sheet is new, reduced production costs and extended storage time and quality stability, improve production efficiency and product quality greatly.
Summary of the invention
Along with deepening continuously of research, the inventor further finds in experiment: magnesium sulfate dressing organizes congestion and edema effective for alleviating, magnesium sulfate dressing is to reach the effect of pain relieving by eliminating edema, combines the Borax with sterilization antisepsis and uses the effect that can bring into play better anti-inflammatory analgetic.Its method is: the magnesium sulfate borax soln that 20%-50% magnesium sulfate and 0.1%～5% Borax and surplus purified water are made into, soak into medical carrier and make the soak sheet, be affixed on affected part and there is beyond thought synergism, to skin zero damage, penetrance and reparation property are strong, can effectively alleviate the stimulation of medicine, improve the toleration of vascular endothelial cell to hypoxia-ischemia, but the generation of prevention of phlebitis, than the stimulation of using magnesium sulfate dressing can alleviate fast and significantly medicine separately, produce the anti-inflammation detumescence analgesic effect that is better than independent magnesium sulfate dressing in part, thereby alleviate redness, the inflammatory reactions such as burning pain, have rapid-action, the characteristics that action time is short.The patient who is particularly suitable for the intravenous drips such as chemotherapy, erysipelas, phlebitis uses.
The purpose of this invention is to provide a kind of occur for the prophylactic treatment local subcutaneous tissue that edema produces swelling pain and inflammation contain magnesium sulfate Borax soak sheet and preparation method thereof, this production technology simply is conducive to the product long term storage, and improved product quality, reduced energy resource consumption.Because the magnesium sulfate dressing sheet (seeing the experiment table) that has added aborning Borax with antiinflammatory antisepsis to be better than former explained hereafter in clinical result of use has the effect with the pain relieving of same elimination swelling pain with ortho-sulfuric acid magnesium soak sheet production technology product, but while for the patient, inflammation occurring, result of use is better, during use, can be affixed on affected part with stator.
For achieving the above object, technical scheme of the present invention is as follows:
A kind of soak sheet that contains magnesium sulfate, is characterized in that it is that 20%～50% magnesium sulfate, 0.1%～5% Borax and surplus purified water and medical carrier form by percetage by weight; Described medical carrier is after the magnesium sulfate borax soln immersion of sterilizing filter filtration is fully moistening, the sealing bags of packing into sealing packing, and through 10～30kGy Co 60 radiation sterilization, preferred Co 60 radiation sterilization is the soak sheet that 15～20kGy makes.
Magnesium sulfate dressing sheet of the present invention, wherein sterilizing filter is 0.22 micron filter membrane or filter element.Described medical carrier is high-hydroscopicity napkin, non-woven fabrics, gauze or medical dressing sheet.Described sealing bags is aluminium foil, medical plastic bag, compound membrane bag, co-extrusion film bag or Polythene Bag.
The present invention further discloses the preparation method of magnesium sulfate dressing sheet, it is characterized in that being undertaken by following step:
(1) 200g～500g magnesium sulfate is dissolved and is made into aqueous solution by purified water, standby;
(2) 0.1g～50g Borax is dissolved and is made into aqueous solution by purified water, standby;
(3), after step (1) Adlerika is added to purified water fully dissolving to 1000ml, through 0.22 micron sterilizing filter, filter, standby;
(4) step (2) borax soln is added in filtrate, control the medicinal liquid pH value 6.5～7.5, then filter through 0.22 micron sterilizing filter, filtrate check magnesium sulfate content is qualified rear standby;
(5) by medical carrier, put into container, after adding the medicinal liquid be up to the standards fully moistening with the immersion of magnesium sulfate borax soln, the sealing bags of packing into sealing packing;
(6) through 10～30kGy Co 60 radiation sterilization, make the magnesium sulfate dressing sheet.
The preparation method of magnesium sulfate dressing sheet of the present invention, wherein all preparation production under clean environmental condition such as Adlerika, borax soln, medical material, the liquid that the magnesium sulfate borax soln filters through 0.22 micron sterilizing filter is placed on airtight fluid reservoir, use full automatic production equipment under clean environmental condition, after bag, section, fill, sealing, then process through 10～30kGy Co 60 radiation sterilization.Prevent the infection that cause in the bacteria attack affected part, guaranteed patient's safe handling.
Why the inventor selects the main component of magnesium sulfate as reducing swelling and alleviating pain, because magnesium sulfate can the antagonism calcium ion, usually magnesium sulfate being used as to calcium ion antagonist uses, and calcium ion is to participate in smooth muscle contraction, so magnesium sulfate can the vasodilator smooth muscle, due to edema be because interstitial fluid too much due to, its tissue is pressed higher, when smooth muscle relaxation, too much interstitial fluid can be along pressure current blood back pipe, and edema will alleviate.
Borax of the present invention is: sodium tetraborate decahydrate, Borax is a kind of good antiinflammatory antiseptic, this medicine stable chemical performance of while, have the anticorrosion analgesic effect of obvious inhibiting bacteria and diminishing inflammation with magnesium sulfate, combine soak can effective percutaneous infiltration and absorption make it eliminate edema, the analgesic effect that diminishes inflammation is rapider, thereby alleviates the inflammatory reactions such as redness, burning pain.
In order further to confirm magnesium sulfate dressing blade technolgy prepared by the present invention, the present invention has carried out following experiment:
(1) 25g, 33g, 36g, 46g, 50g magnesium sulfate are dissolved and are made into aqueous solution by purified water, standby;
(2) 1.5g, 2g, 3g, 4 g, 4.5,5g, 5.5g Borax are dissolved and are made into aqueous solution by purified water, standby;
(3) will
after the Adlerika of above variable concentrations adds purified water and fully dissolves to 100ml, through 0.22 micron sterilizing filter, filter, standby;
(4) will
the borax soln of above variable concentrations adds in the magnesium sulfate filtrate of variable concentrations, controls the medicinal liquid pH value 6.5-7.5, and whether observe it has crystallization or precipitation.
The screening of prescription of the present invention
While showing to add 0.1%～5% Borax in 20%-50% Adlerika by above experiment, its solution is as supernatant liquid, without crystallization or precipitation; Be still supernatant liquid when in 50% Adlerika, adding 5.5% Borax, but have a small amount of white precipitate to produce, so the magnesium sulfate borax soln is that 20%-50% magnesium sulfate, 0.1%～5% Borax and surplus purified water form by percetage by weight.
Magnesium sulfate dressing sheet prepared by the present invention is compared its distinguishing feature had with the magnesium sulfate dressing sheet of former explained hereafter and is:
The magnesium sulfate dressing sheet of 1, adopting new technology and producing, production technology is simple, in general clean production environment, produces and gets final product, and environmental protection and energy saving, reduce production costs.
2, the process water that former explained hereafter magnesium sulfate dressing sheet is used is water for injection, and cost is higher; The magnesium sulfate dressing blade technolgy water that new technology is produced adopts purified water to reduce production cost.
3, the magnesium sulfate dressing sheet method of former explained hereafter requires condition production at 10,000 grades of clean environments through high temperature sterilize.Selecting medical dressing sheet, carrier and packaging material to be necessary for can be high temperature resistant, requires high cost high.The magnesium sulfate dressing sheet of adopting new technology and producing adds the borax soln with inhibiting bacteria and diminishing inflammation antisepsis in Adlerika, and the magnesium sulfate borax soln filters through 0.22 micron sterilizing filter of secondary, the antibacterial in the filtering raw material, microorganism; Filtered liquid is placed on airtight fluid reservoir, uses fully-automatic equipment production under clean environmental condition, after bag, section, fill, sealing, then processes through 10～30kGy Co 60 radiation sterilization.Prevent the infection that cause in antibacterial, microbiological attack affected part, guaranteed patient's safe handling.
So 4, adopt new technology the magnesium sulfate dressing sheet produced owing to not needing high temperature sterilize can use common aluminium foil, medical plastic bag, compound membrane bag, co-extrusion film bag, Polythene Bag etc. as sealing bags.
So 5, adopt new technology the magnesium sulfate dressing sheet produced owing to not needing high temperature sterilize can select common medical carrier material.
6, owing to adding the borax soln with inhibiting bacteria and diminishing inflammation antisepsis in Adlerika, the effect of the antiseptic played, the storage time of the magnesium sulfate dressing sheet produced of making to adopt new technology can extend more than 1 year.
7, Borax is a kind of good antiinflammatory antiseptic, this medicine stable chemical performance of while, have the anticorrosion analgesic effect of obvious inhibiting bacteria and diminishing inflammation with magnesium sulfate, combine soak can effective percutaneous infiltration and absorption make it eliminate edema, the analgesic effect that diminishes inflammation is rapider, thereby alleviates the inflammatory reactions such as redness, burning pain.
For the beneficial effect of the magnesium sulfate dressing sheet that further prepared by proof the present invention, the present invention has carried out following contrast experiment:
One, the comparative test of the magnesium sulfate dressing sheet of the magnesium sulfate dressing sheet of former explained hereafter and new technology manufacture:
Sample Y: with the magnesium sulfate dressing sheet of former explained hereafter, specification: 5 * 10cm, be comprised of Adlerika and non-woven fabrics containing 33%.
Sample X: the magnesium sulfate dressing sheet of producing by new technology, specification: 5 * 10cm, be comprised of the Adlerika containing 33% and 2% borax soln and non-woven fabrics.
Sample Y, sample X are spread on respectively to patient's swelling position with reference to U.S. venous transfusion nurses association (INS) criterion and the phlebitic clinical practice for the treatment of by Chinese herbs, take that to observe assessment limb swelling situation as follows to its efficacy assessment standard as the course for the treatment of in 3 days:
The A produce effects: subcutaneous tissue swelling is disappeared fully, and the distending pain sense disappears, and it is normal that sensory perception recovers, and freely, it is normal that skin elasticity is recovered in activity.
B is effective: subcutaneous tissue swelling is disappeared fully, and the distending pain sense disappears, and it is normal that sensory perception recovers, and it is normal that skin elasticity is recovered.
C is invalid: subcutaneous tissue swelling is disappeared not exclusively, and the distending pain sense exists, and sensory perception is blunt, and it is poor that skin elasticity is recovered.
20 routine patients with cerebrovascular disease clinical effectiveness statistics
20 routine patients with cerebrovascular disease continuous transfusions, more than 7 days, because transfusion time is long, particularly contain the mannitol that height oozes effect in medicinal liquid, cause subcutaneous dropsy, show as local organization swelling, cause subcutaneous dropsy, the swelling position of directly applying ointment or plaster.The clinical effectiveness statistics.The patient applies sample Y, sample X is spread on to swelling place respectively for one day 3 times, through the treatments of 3 days 20, is the patient clinical result: all obtained curative effect preferably.But 10 patients of the magnesium sulfate dressing sheet sample X produced by new technology had 9 standards that reach the A produce effects at the 2nd day, the 3rd day 10 all reach the A standard; With 10 patients of the magnesium sulfate dressing sheet sample Y of former explained hereafter, 7 standards that reach the A produce effects were arranged at the 2nd day, within the 3rd day, have 9 to reach the A standard.The magnesium sulfate dressing sheet of producing by new technology as can be seen here is better than the magnesium sulfate dressing sheet of former explained hereafter.
Two, magnesium sulfate dressing sheet of the present invention with the contrast experiment of magnesium sulfate dressing sheet on period of storage of former explained hereafter:
Sample Y: with the magnesium sulfate dressing sheet of former explained hereafter, specification: 5 * 10cm, be comprised of Adlerika and non-woven fabrics containing 33%; 10,000 grades of clean environment productions, adopt the high temperature sterilize method to process.
Sample X: new production technology and the preparation method of magnesium sulfate dressing sheet of producing by new technology, specification: 5 * 10cm, be comprised of the Adlerika containing 33% and 2% borax soln and non-woven fabrics; In general clean environmental condition preparation, produce, the liquid that the magnesium sulfate borax soln filters through 0.22 micron sterilizing filter is placed on airtight fluid reservoir, use full automatic production equipment under clean environmental condition, after bag, section, fill, sealing, then process through 20kGy Co 60 radiation sterilization.
Under similarity condition is stored, sample Y and 18 months sample X resting periods, 21 months, 24 months, 27 months, 30 months are observed to statistics, 2 groups of sample situations of mildewing are observed to statistics, the numbered samples that mildewed is not at record.
With the magnesium sulfate dressing sheet of former explained hereafter and contrast experiment's table of the magnesium sulfate dressing sheet storage of producing by new technology
Discuss: with 3 samples of magnesium sulfate dressing sheet of former explained hereafter, storing the situation that mildews in 21-27 months; The magnesium sulfate dressing sheet of producing by new technology is stored 30 monthly not mildewing.
Conclusion: the magnesium sulfate Borax soak sheet period of storage of producing by new technology should be more than 30 months, the magnesium sulfate dressing sheet period of storage of producing by new technology on period of storage can extend 1 year, and the magnesium sulfate dressing sheet of producing by new technology is at the magnesium sulfate dressing sheet be better than aspect storage by former explained hereafter.
The present invention further discloses the magnesium sulfate dressing sheet and the application of swelling pain that edema produces and aspect of inflammation occurs and in the application aspect preparation prophylactic treatment phlebitis in preparation treatment local subcutaneous tissue.
Local subcutaneous tissue occurs that swelling pain that edema produces and inflammation are divided into 1, mechanicalness phlebitis: wrongful fixing means: site of puncture is not fixed, causes the slip of needle tubing.2, chemical phlebitis: drug dilution is not enough, transfusion acid, basicity are too high, the excessive concentration of solute, the diversity of remaining needle material are all to cause the phlebitic reason of chemical.General clinically occur that general reaction is low weight, with slight heating; Laboratory examination occurs: leukocyte count slightly increases, and erythrocyte sedimentation rate such as slightly speeds at the symptom.
The magnesium sulfate dressing sheet of producing by new technology is in the experiment aspect chemical phlebitis, mechanicalness phlebitis:
Experiment is divided into 2 groups, and every group of 10 routine patients are respectively chemical phlebitis, the clinical appearance of mechanicalness phlebitis: the symptom of the swollen pain of edema and aspect of inflammation, and with slight heating; Laboratory examination occurs: leukocyte count slightly increases, and erythrocyte sedimentation rate such as slightly speeds at the disease.Apply ointment or plaster swelling position 5 days of the magnesium sulfate dressing sheet of producing by new technology, observed statistical result 3 every day.
The A produce effects: subcutaneous tissue swelling is disappeared fully, and the distending pain sense disappears, and it is normal that sensory perception recovers, and freely, it is normal that skin elasticity is recovered in activity; Without slight heating paresthesia; Laboratory examination: leukocyte count, erythrocyte sedimentation rate is normal.
B is effective: subcutaneous tissue swelling is disappeared fully, and the distending pain sense disappears, and it is normal that sensory perception recovers, and it is normal that skin elasticity is recovered: without slight heating paresthesia; Laboratory examination: leukocyte count slightly increases or erythrocyte sedimentation rate slightly speeds not yet recovery normally.
C is invalid: subcutaneous tissue swelling is disappeared not exclusively, and the distending pain sense exists, and sensory perception is blunt, and it is poor that skin elasticity is recovered.
Slight heating is still arranged; Laboratory examination occurs: leukocyte count slightly increases or erythrocyte sedimentation rate such as slightly speeds at the disease.
20 routine chemical phlebitis, mechanicalness phlebitis patient clinical result statistics
Every group of 10 routine patients are respectively chemical phlebitis, the clinical appearance of mechanicalness phlebitis: the symptom of the swollen pain of edema and aspect of inflammation, and with slight heating; Laboratory examination occurs: leukocyte count slightly increases, and erythrocyte sedimentation rate such as slightly speeds at the disease.The swelling position 5 day every day 3 times of applying ointment or plaster of producing by new technology, observed, through 20 patient clinical results of the treatments of 5 days: what to have obtained satisfied curative effect be A accounts for 90%; Subcutaneous tissue swelling is disappeared fully, and the distending pain sense disappears, and it is normal that sensory perception recovers, and freely, it is normal that skin elasticity is recovered in activity, without slight heating paresthesia; Laboratory examination: leukocyte count, it is normal that erythrocyte sedimentation rate recovers.Through 10 chemical phlebitis patient clinical results of the treatments of 4 days: what to have obtained satisfied curative effect be A accounts for 80%.Through 10 mechanicalness phlebitis patient clinical results of the treatments of 4 days: what to have obtained satisfied curative effect be A accounts for 70%.The magnesium sulfate dressing sheet of producing by new technology as can be seen here is in the good effect that has aspect prophylactic treatment chemical phlebitis, mechanicalness phlebitis.
The good effect that the preparation method of magnesium sulfate dressing sheet disclosed by the invention has is:
(1) in original prescription, add Borax to apply at the swelling position, make it eliminate edema, the analgesic effect that diminishes inflammation is stronger, thereby the inflammation such as redness, burning pain that alleviate the patient reach, alleviating swells and ache eliminates the purpose of edema, be more suitable for chemical phlebitis, the clinical appearance of mechanicalness phlebitis: the symptom of the swollen pain of edema and aspect of inflammation, and with slight heating; Laboratory examination occurs: leukocyte count slightly increases, and erythrocyte sedimentation rate such as slightly speeds at the disease.。
(2) prove by experiment, the magnesium sulfate dressing sheet that adopts new preparation method to produce can reduce production costs, and energy-saving and emission-reduction adopt mechanization production to enhance productivity.Can reduce energy consumption cost, the cost of raw material and packing cost, increase work efficiency.
(3) the present invention is owing to adopting mechanization production can effectively control the quality of product, and the qualification rate of finished product increases substantially, constant product quality.Owing to having added its clinical result of use of Borax with antiinflammatory antisepsis to be better than the magnesium sulfate dressing sheet of former explained hereafter in the magnesium sulfate dressing sheet of producing of adopting new technology, thereby guarantee the safe and effective of product.
The specific embodiment
In order to explain more fully enforcement of the present invention, provide the embodiment of following preparation method.These embodiments are only to explain rather than limit the scope of the invention.Below by typical embodiment, the present invention is described further.Wherein magnesium sulfate, Borax (sodium tetraborate decahydrate) all have commercially available.
Embodiment 1
(1) 330g magnesium sulfate is dissolved and is made into aqueous solution by purified water, standby;
(2) the 15g Borax is dissolved and is made into aqueous solution by purified water, standby;
(3) will be 1. after Adlerika adds purified water and fully dissolve to 1000ml, through 0.22 micron sterilizing filter, filter, standby;
(4) will
borax soln adds in filtrate, controls the medicinal liquid pH value 6.8, then filters through 0.22 micron sterilizing filter, and the filtrate of filtrate after check magnesium sulfate content is qualified is placed on airtight fluid reservoir,
(5) use full automatic production equipment under clean environmental condition, through bag, section, fill, sealing;
(6) sealing; After, then process through 15kGy Co 60 radiation sterilization.
(7) carry out limit test of microbe after qualified product carry out outer package by the Different Package specification.
Embodiment 2
(1) 460g magnesium sulfate is dissolved and is made into aqueous solution by purified water, standby;
(2) the 20g Borax is dissolved and is made into aqueous solution by purified water, standby;
(3) will be 1. after Adlerika adds purified water and fully dissolve to 1000ml, through 0.22 micron sterilizing filter, filter, standby;
(4) will
borax soln adds in filtrate, controls the medicinal liquid pH value 7.0, then filters through 0.22 micron sterilizing filter, and the filtrate of filtrate after check magnesium sulfate content is qualified is placed on airtight fluid reservoir,
(5) use full automatic production equipment under clean environmental condition, through bag, section, fill, sealing;
(6) sealing; After, then process through 20kGy Co 60 radiation sterilization.
(7) carry out limit test of microbe after qualified product carry out outer package by the Different Package specification.
Claims (9)
1. a soak sheet that contains magnesium sulfate, is characterized in that it is that 20%-50% magnesium sulfate, 0.1%～5% Borax and surplus purified water and medical carrier form by percetage by weight; Described medical carrier is after the magnesium sulfate borax soln immersion of sterilizing filter filtration is fully moistening, the sealing bags of packing into sealing packing, the soak sheet of making through 10～30kGy Co 60 radiation sterilization; Borax wherein is sodium tetraborate.
2. magnesium sulfate dressing sheet claimed in claim 1, wherein sterilizing filter is 0.22 micron filter membrane or filter element.
3. the described magnesium sulfate dressing sheet of claim 1-2 any one, medical carrier wherein is high-hydroscopicity napkin, non-woven fabrics, gauze or medical dressing sheet.
4. be shaped as rectangle, square, circle, ellipse, rectangle or triangle.
5. magnesium sulfate dressing sheet claimed in claim 1, is characterized in that described sealing bags is aluminium foil, medical plastic bag, compound membrane bag, co-extrusion film bag or Polythene Bag.
6. magnesium sulfate dressing sheet claimed in claim 1, wherein said Co 60 radiation sterilization is preferably 15～20kGy.
7. one kind prepares the preparation method that the described anti-inflammatory analgetic of claim 1 is eliminated edema magnesium sulfate dressing sheet, it is characterized in that being undertaken by following step:
(1) 200g～500g magnesium sulfate is dissolved and is made into aqueous solution by purified water, standby;
(2) 0.1g～50g Borax is dissolved and is made into aqueous solution by purified water, standby;
(3), after step (1) Adlerika is added to purified water fully dissolving to 1000ml, through 0.22 micron sterilizing filter, filter, standby;
(4) step (2) borax soln is added in filtrate, control the medicinal liquid pH value 6.5～7.5, then filter through 0.22 micron sterilizing filter, filtrate check magnesium sulfate content is qualified rear standby;
(5) by medical carrier, put into container, after adding the medicinal liquid be up to the standards fully moistening with the immersion of magnesium sulfate borax soln, the sealing bags of packing into sealing packing;
(6) through 10～30kGy Co 60 radiation sterilization, make the magnesium sulfate dressing sheet.
8. the described magnesium sulfate dressing sheet of claim 1 swelling pain of edema generation and the application aspect the inflammation medicine occur in preparation treatment local subcutaneous tissue.
9. the application of the described magnesium sulfate dressing sheet of claim 1 aspect preparation prevention and therapeutical chemistry induced phlebitis, mechanicalness phlebitis.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536961A (en) * | 2013-11-07 | 2014-01-29 | 邢文 | Medical cold compress bandage and production method thereof |
| CN104069539A (en) * | 2014-07-23 | 2014-10-01 | 桑洪义 | Medical hypertonic colloid dressing and preparation method thereof |
| CN105147726A (en) * | 2015-09-25 | 2015-12-16 | 尹楠楠 | Medical application preventing and curing phlebitis and preparing method thereof |
| CN105288633A (en) * | 2015-03-02 | 2016-02-03 | 天津瑞安医药科技发展有限公司 | Compound magnesium sulfate wet compress and preparation method thereof |
| CN112478321A (en) * | 2020-12-08 | 2021-03-12 | 苑占浩 | Method for disinfecting wet and dry napkin for infants |
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| CN101024095A (en) * | 2006-05-11 | 2007-08-29 | 贾国平 | Sterilized magnesium sulfate dressing preparation |
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| CN101024095A (en) * | 2006-05-11 | 2007-08-29 | 贾国平 | Sterilized magnesium sulfate dressing preparation |
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| 方淑贤等主编: "《临床药物指南》", 31 May 2005, 北京：科学出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536961A (en) * | 2013-11-07 | 2014-01-29 | 邢文 | Medical cold compress bandage and production method thereof |
| CN104069539A (en) * | 2014-07-23 | 2014-10-01 | 桑洪义 | Medical hypertonic colloid dressing and preparation method thereof |
| CN105288633A (en) * | 2015-03-02 | 2016-02-03 | 天津瑞安医药科技发展有限公司 | Compound magnesium sulfate wet compress and preparation method thereof |
| CN105147726A (en) * | 2015-09-25 | 2015-12-16 | 尹楠楠 | Medical application preventing and curing phlebitis and preparing method thereof |
| CN112478321A (en) * | 2020-12-08 | 2021-03-12 | 苑占浩 | Method for disinfecting wet and dry napkin for infants |
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Application publication date: 20130605 |