CN105816907A

CN105816907A - Medical gel and preparation method for utilizing medical gel to prepare gel wet-patch

Info

Publication number: CN105816907A
Application number: CN201610241091.7A
Authority: CN
Inventors: 朱彩丽
Original assignee: SHANGHAI CHARHE PHARMACEUTICAL TECHNOLOGY Co Ltd
Current assignee: SHANGHAI CHARHE PHARMACEUTICAL TECHNOLOGY Co Ltd
Priority date: 2016-04-19
Filing date: 2016-04-19
Publication date: 2016-08-03

Abstract

The invention discloses medical gel comprising the following components in weight ratio: 10%-60% of magnesium sulfate, 0.01%-5% of plant extracts, 0.5%-15% of glycerol, 0.1%-5% of ethyl alcohol, 0.5%-20% of a hydrophilic polymer material, 0.5%-15% of PEG40-hydrogenated castor oil, 0.001%-5% of an antibacterial agent and the balance of purified water; the plant extracts are plant extracts with functions of promoting penetration, inhibiting bacteria, diminishing inflammation and relieving pain. The invention further discloses a gel wet-patch prepared by utilizing the medical gel, and a preparation method thereof. The medical gel provided by the invention has the functions of decreasing the level of dropsy, diminishing inflammation, relieving pain, inhibiting bacteria, protecting skin and the like, and is non-irritative to a human body; the use is safe, the medical gel takes effect quickly, and the curative effect is good.

Description

A kind of medical gel and for preparing the preparation method of gel wet application

Technical field

The present invention relates to a kind of medical gel, particularly relate to one and utilize medical gel preparation to have elimination edema, control Treat the gel wet application of the function such as phlebitis and soft tissue injury.

Background technology

50% magnesium sulfate is hyperosmotic solution, the moisture in available concentration difference absorptive tissue, plays the effect of detumescence.Simultaneously Magnesium ion can suppress Calcium-ion absorption, thus suppresses the contraction of vascular smooth muscle, improves the microcirculation of edematous site, interstitial fluid Backflow blood vessel, thus alleviate local and ooze out.Owing to blood circulation is improved, strengthen the phagocytosis of metabolism and leukocyte Function, reaches the purpose of infection and antiinflammatory.

Clinically, conventional 30%-50% Adlerika soaks gauze or towel spreads on affected part, and the method is in operation Need to add at set intervals Adlerika, and Adlerika adhesional wetting sheet or patient's clothing the most often occur The situation of thing, makes troubles to patient and medical personnel.It is wet that existing magnesium sulfate wet application many employings non-woven fabrics soaks magnesium sulfate Deposited fluid-tight is loaded in packaging bag, during use, wet application is spread on affected part, wraps up with preservative film, prevents moisture evaporation or liquid stream Go out to bedew sheet or medicated clothing.Patient's illing skin is in the case of airproof, and the long period contacts high concentration salt solutions, causes Skin immune function controlling declines, susceptible or cause blister erythema etc..

Patent (CN 101485680 A) discloses a kind of compound magnesium sulphate catablasm and preparation method thereof.In the program, Primary medicinal component magnesium sulfate content is far below clinical typical concentrations, and to make cataplasma be solid-state, and medicine is risen slow releasing function, Though addition Mentholum is as permeation enhancers, but not as good as 50% magnesium sulfate dressing liquid instant effect.Lidocaine hydrochloride clinic is mainly used in Local anesthetic, has analgesic effect.Content and the clinical data of this patent with reference to lidocaine hydrochloride and magnesium sulfate, it is known that Compound magnesium sulphate catablasm has preferable analgesic effect, and its treatment edema and phlebitic effect are relatively weak.

Patent (CN 104107190 A) discloses a kind of disposable wet application and preparation method thereof, its soak liquid exist with Lower deficiency: one, mannitol intravenous administration is administered, reaches dehydration by osmotic diuresis, and external application can not reach dehydration Effect.Two, dexamethasone is glucocorticoid medicine, is mainly used in dermatitis, eczema, and human body is had relatively first mate to make by life-time service With.

Summary of the invention

Because the drawbacks described above of prior art, the technical problem to be solved be to provide a kind of medical gel and The wet application prepared based on this gel, this wet application have the effect such as edema, antiinflammatory, pain relieving, antibacterial, skin protection and to human body without Zest, uses safety, rapid-action, good effect.

Present invention also offers the preparation method of above-mentioned wet application.

For achieving the above object, the invention provides a kind of medical gel, be made up of following components and weight ratio thereof: 10%- 60% magnesium sulfate, 0.01%-5% plant extract, 0.5%-15% glycerol, 0.1%-5% ethanol, 0.5%-20% hydrophilicity macromolecule material Material, 0.5%-15%PEG40-castor oil hydrogenated, 0.001%-5% antibacterial, surplus are purified water.

Described plant extract is to have saturating, antibacterial, the antiinflammatory of rush, the plant extract of analgesic effect, can be to have The material of transdermal enhancer effect, such as Oleum menthae, Borneolum Syntheticum etc., it is also possible to has antibacterial, antiinflammatory, pain relieving or goes edema effect Plant extract, as Cortex Moutan, Rhizoma Curcumae Longae, Folium eucalypti globueli (Eucalyptus globulus Labill.), Camellia sinensis, Herba thymi vulgaris, Calendula officinalis, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, Rhizoma Chuanxiong, Herba Portulacae, Aloe, Radix Hamamelidis Mollis, Flos Chrysanthemi Indici, Flos Lonicerae, Herba Taraxaci, Herba Schizonepetae, lavandula angustifolia, Flos Caryophylli, Herba Rosmarini Officinalis, Radix Sophorae Flavescentis, Fructus Sapindi Mukouossi, Radix Zanthoxyli, Semen daturae, The Radix Stemonae, Poria, Flos Matricariae chamomillae, Radix Scutellariae, Rhizoma Coptidis, rutin, Salvia japonica Thunb., Rhizoma Polygoni Cuspidati, Semen Myristicae, Saw Palmetto P.E etc..

Described antibacterial can be inorganic antiseptic (such as: silver ion etc.), organic antibacterial agent (such as: quaternary ammonium salt etc.), sky So antibacterial (such as: chitosan etc.) or be have plant extract (such as the clove oil etc.) one therein of bacteriostatic activity or its Meaning combination.Concrete, described antibacterial is silver ion, quaternary ammonium salt, biguanides, sorbic acid and salt thereof, parabens, shell The one therein such as polysaccharide or its combination in any, or be Efficient antibacterial, anticorrosion plant extract.

Described hydrophilic high molecular material be sodium carboxymethyl cellulose, chitosan, gelatin, agar, carboxy-propyl cellulose, Xanthan gum, carrageenan, locust bean gum, guar gum, sodium alginate, pectin, arabic gum and starch and derivant, hydroxy ethyl fiber One therein or its combination in any such as element, polyvinyl alcohol, polyacrylic acid, polyvinylpyrrolidone.

A kind of gel wet application, including medical gel and medical carrier, described medical carrier be non-woven fabrics, absorbent cotton, Gauze, sponge, absorbent paper is therein a kind of or its combination in any or the antiseptic dressing prepared for above-mentioned material.

Described carrier includes two sides, is coated with breathing waterproof film away from the one side contacted with affected part；Described is ventilative anti- Moisture film uses the material of polypropylene type, polyethylene kind, polyurethanes one of which or its any combination to make.So can be to carrier In medical gel play and reduce evaporation and other fixing material laminating etc. causes the effect of loss.

The preparation method of a kind of gel wet application, comprises the following steps:

(1) purified water is boiled 3-10 minute, be cooled to room temperature (now-making-now-using)；

(2) take 125g-500g magnesium sulfate, add 500ml purified water and dissolve；

(3) 30ml-50ml70% ethanol, 1ml-5mlPEG40-castor oil hydrogenated and 5ml-150ml glycerol are mixed, add 1ml- 5ml plants essential oil dissolves；

(4) take 10g-200g hydrophilic high molecular material and 0.1g-50g anti-biotic material, add 300ml purified water, mix well；

(5) by (2), (3), (4) three kinds of solution mixings, it is settled to 1000ml by purified water；

(6) take out after soak medical carrier at least half an hour of above-mentioned preparation.

The invention has the beneficial effects as follows: present invention application hydrophilic high molecular material does Adlerika carrier, can be effective Water conservation and there is preferable breathability.Plant extract is added, as the transdermal enhancer such as Oleum menthae, Borneolum Syntheticum can promote in gel Drug Percutaneous Absorption, makes drug effect faster.Additionally, Oleum menthae separately has the effects such as antibacterial, antiinflammatory, pain relieving and slight local anaesthesia. Borneolum Syntheticum separately has the effects such as antibacterial, antiinflammatory, detumescence, pain relieving.Additionally add and there is skin care effect or antiinflammatory, antibacterial, pain relieving, detumescence The plant extract of effect, can protect the skin from again injuring.Radix Glycyrrhizae extract has antibacterial, antiinflammatory, antiallergic, solution carbuncle The effects such as sore and reduction drug toxicity.Have plant extract antibacterial, antiinflammation also have Herba Portulacae, Aloe, Radix Hamamelidis Mollis, Flos Chrysanthemi Indici, Flos Lonicerae, Herba Taraxaci, Herba Schizonepetae, Calendula officinalis extract.Adding antibacterial in gel, not only to make gel have inherent antibacterial Property, enhanced stability, and in use can suppress skin surface microbial growth.

The selected plant extract of gel wet application of the present invention, and add antibacterial, skin care ingredient, non-stimulated to human body Property, use safety, rapid-action, good effect.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described:

Embodiment one:

A kind of medical gel, is made up of following components and weight ratio thereof: 60% magnesium sulfate, 3% plant extract, 2% glycerol, 3% second Alcohol, 10% hydrophilic high molecular material, 4%PEG40-castor oil hydrogenated, 0.03% silver ion, surplus are purified water；

Embodiment two:

A kind of medical gel, is made up of following components and weight ratio thereof: 30% magnesium sulfate, 0.5% plant extract, 12% glycerol, 0.5% ethanol, 4% hydrophilic high molecular material, 2%PEG40-castor oil hydrogenated, 5% chitosan, surplus are purified water；

Embodiment three:

A kind of medical gel, is made up of following components and weight ratio thereof: 12.5% magnesium sulfate, 4% plant extract, 6% glycerol, 2% Ethanol, 16% hydrophilic high molecular material, 5%PEG40-castor oil hydrogenated, 0.1% quaternary ammonium salt, surplus are purified water；

Embodiment four:

A kind of medical gel, is made up of following components and weight ratio thereof: 12.5%-60% magnesium sulfate, 0.01%-2% Oleum menthae, 0.01%-1% paeonol, 0.01%-1% lonicera oil, 10%-20% sodium carboxymethyl cellulose, 1%-5%PEG40-castor oil hydrogenated, 1%-5% chitosan, 0.5%-15% glycerol, 0.1%-3% ethanol, surplus purified water.

Embodiment five:

A kind of medical gel, is made up of following components and weight ratio thereof: 60% magnesium sulfate, 0.5% Oleum menthae, 0.5% paeonol, 0.5% lonicera oil, 10%-20% sodium carboxymethyl cellulose, 1%-5%PEG40-castor oil hydrogenated, 1%-5% chitosan, 10% glycerol, 3% ethanol, surplus purified water.

Embodiment six:

A kind of medical gel, is made up of following components and weight ratio thereof: 12.5%-60% magnesium sulfate, 0.01%-3% Borneolum Syntheticum, 0.01%- 5% aloe, 5%-10% sodium carboxymethyl cellulose, 1%-5%PEG40-castor oil hydrogenated, 1%-5% gelatin, 1%-15% glycerol, 0.1%-3% ethanol, 0.005%-0.04% silver ion, surplus purified water.

Embodiment seven:

A kind of medical gel, is made up of following components and weight ratio thereof: 12.5%-60% magnesium sulfate, 0.01%-2% Oleum menthae, 0.01%-5% Oleum lavandula angustifolia, 0.5%-1.5% sodium carboxymethyl cellulose, 1%-5%PEG40-castor oil hydrogenated, 1%-15% glycerol, 0.1%-3% ethanol, 0.01%-0.2% quaternary ammonium salt, surplus purified water.

Embodiment eight:

A kind of medical gel, is made up of following components and weight ratio thereof: 10%-60% magnesium sulfate, 0.01%-5% plant extract, 0.5%-15% glycerol, 0.1%-5% ethanol, 0.5%-20% sodium carboxymethyl cellulose, 0.5%-15%PEG40-castor oil hydrogenated, 1%- 5% chitosan, 0.01%-0.2% quaternary ammonium salt, surplus are purified water.Described gel adds chitosan and quaternary ammonium salt, acts primarily as and kill Bacterium effect.Additionally, the addition of chitosan improves the moisture retention of gel.

Embodiment nine:

(2) take 125g-500g magnesium sulfate, add 500ml purified water and dissolve；

(3) 30ml-50ml70% ethanol, 1ml-10mlPEG40-castor oil hydrogenated and 5ml-150ml glycerol are mixed, add 1g- 30g Borneolum Syntheticum and 1ml-20ml aloe dissolve；

(4) take 10g-200g sodium carboxymethyl cellulose, mix with 10g-50g chitosan or 0.1g-2g quaternary ammonium salt, add 300ml Purified water, mixes well；

(5) by (2), (3), (4) two kinds of solution mixings；It is settled to 1000ml by purified water；

(6) take out after soak medical carrier half an hour of above-mentioned preparation.

Embodiment ten:

(1) purified water is boiled 5 minutes, be cooled to room temperature (now-making-now-using)；

(2) take 500g magnesium sulfate, add 500ml purified water heating for dissolving；

(3) 5ml70% ethanol, 10ml glycerol and 8mlPEG40-castor oil hydrogenated are mixed, add 1ml Oleum menthae and 5ml smokes clothing Grass oil dissolves.

(4) take 20g sodium carboxymethyl cellulose, mix with 50g chitosan, add 300ml purified water and mix well；

Embodiment 11:

(3) 5ml95% ethanol, 10ml glycerol and 8mlPEG40-castor oil hydrogenated are mixed, add 1g Borneolum Syntheticum and 5ml Aloe oil soluble Solve.

(4) take 20g sodium carboxymethyl cellulose, mix with 1.5g quaternary ammonium salt, add 300ml purified water and mix well；

Embodiment 12:

(2) take 330g magnesium sulfate, add 500ml purified water heating for dissolving, after being cooled to room temperature, add 0.45g silver nitrate and make It dissolves；

(3) 5ml70% ethanol, 10ml glycerol and 8mlPEG40-castor oil hydrogenated are mixed, add 1ml Oleum menthae and 5ml Aloe Oil dissolves.

(4) take 100g sodium carboxymethyl cellulose, mix with 10g gelatin, add 300ml purified water and mix well；

Compliance test result

By rabbit auricular vein total length preserved skin, intravenous injection 20% mannitol, three times a day, continuous three days, set up scleroma type phlebitis Model.

4 groups are divided at random, often group 6 by successful for modeling laboratory animal.Matched group: 50% magnesium sulfate room temperature soak treatment；Real Test group: embodiment four room temperature soak is treated.Soak treats every day 4 times, each 45min.Soak time 3d altogether.

Soak was drawn materials in right side auricular vein after 72 hours, carried out observing under optical microscope after staining pathologic section, Observation item is: extent of hemorrhage, cell infiltration degree, edema degree around blood vessel wall damaged condition, blood vessel, to observation item Setting up level index, degree is the highest, and score is the highest: with (-) it is 0 point, (+) it is 1 point, (++) is 2 points , (+++) is 3 points.

Carry out variance analysis after test data is added up, find experimental group indices be significantly better than that matched group (p < 0.05) the gel wet application that, experimental group uses has obviously advantage to phlebitis curative effect.

The preferred embodiment of the present invention described in detail above.Should be appreciated that those of ordinary skill in the art without Need creative work just can make many modifications and variations according to the design of the present invention.Therefore, all technology in the art Personnel are available by logical analysis, reasoning, or a limited experiment the most on the basis of existing technology Technical scheme, all should be in the protection domain being defined in the patent claims.

Claims

1. a medical gel, it is characterised in that be made up of following components and weight ratio thereof: 10%-60% magnesium sulfate, 0.01%-5% Plant extract, 0.5%-15% glycerol, 0.1%-5% ethanol, 0.5%-20% hydrophilic high molecular material, 0.001%-5% antibacterial, 0.5%-15%PEG40-castor oil hydrogenated, surplus are purified water；Described plant extract for have rush thoroughly or antiinflammatory, pain relieving, Antibacterial, the plant extract of skin care effect.

2. medical gel as claimed in claim 1 a kind of, it is characterised in that described plant extract is Herba Menthae, Borneolum Syntheticum, male Cortex Moutan, Rhizoma Curcumae Longae, Folium eucalypti globueli (Eucalyptus globulus Labill.), Camellia sinensis, Herba thymi vulgaris, Calendula officinalis, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, Rhizoma Chuanxiong, Herba Portulacae, Aloe, Radix Hamamelidis Mollis, Flos Chrysanthemi Indici, gold Flos Lonicerae, Herba Taraxaci, Herba Schizonepetae, rutin, Salvia japonica Thunb., Rhizoma Polygoni Cuspidati, Semen Myristicae, sabal, lavandula angustifolia, Flos Caryophylli, Fructus Sapindi Mukouossi, Radix Zanthoxyli, top Eggplant, the Radix Stemonae, Poria, Flos Matricariae chamomillae, Radix Scutellariae, Rhizoma Coptidis, Herba Rosmarini Officinalis, the extract one therein such as Radix Sophorae Flavescentis, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Piperis, Bulbus Allii or Its combination in any；

Described antibacterial be silver ion, quaternary ammonium salt, biguanides, sorbic acid and salt thereof, parabens, chitosan etc. wherein One or its combination in any, or be Efficient antibacterial, anticorrosion plant extract；

Described hydrophilic high molecular material is sodium carboxymethyl cellulose, chitosan, gelatin, agar, carboxy-propyl cellulose, xanthan Glue, carrageenan, locust bean gum, guar gum, sodium alginate, pectin, arabic gum and starch and derivant thereof, hydroxyethyl cellulose, Polyvinyl alcohol, polyacrylic acid, polyvinylpyrrolidone one therein or its combination in any.

3. a kind of medical gel as claimed in claim 1 or 2, it is characterised in that be made up of following components and weight ratio thereof: 12.5% magnesium sulfate, 4% plant extract, 6% glycerol, 2% ethanol, 16% hydrophilic high molecular material, 8%PEG40-hydrogenated castor Oil, 0.1% quaternary ammonium salt, surplus are purified water.

4. a kind of medical gel as claimed in claim 1 or 2, it is characterised in that be made up of following components and weight ratio thereof: 12.5%-60% magnesium sulfate, 0.01%-2% Oleum menthae, 0.01%-1% paeonol, 0.01%-1% lonicera oil, 10%-20% carboxymethyl Sodium cellulosate, 1%-5%PEG40-castor oil hydrogenated, 1%-5% chitosan, 0.5%-15% glycerol, 0.1%-5% ethanol, surplus purification Water.

5. a kind of medical gel as claimed in claim 1 or 2, it is characterised in that be made up of following components and weight ratio thereof: 12.5%-60% magnesium sulfate, 0.01%-3% Borneolum Syntheticum, 0.01%-5% aloe, 5%-10% sodium carboxymethyl cellulose, 1%-5% gelatin, 1%-5%PEG40-castor oil hydrogenated, 0.5%-15% glycerol, 0.1%-5% ethanol, 0.01%-0.2% quaternary ammonium salt, surplus purified water.

6. a kind of medical gel as claimed in claim 1 or 2, it is characterised in that be made up of following components and weight ratio thereof: 12.5%-60% magnesium sulfate, 0.01%-2% Oleum menthae, 0.01%-5% Oleum lavandula angustifolia, 0.5%-1.5% sodium carboxymethyl cellulose, 1%-5% PEG40-castor oil hydrogenated, 0.5%-15% glycerol, 0.1%-5% ethanol, 0.005%-0.04% silver ion, surplus purified water.

7. a kind of medical gel as claimed in claim 1 or 2, it is characterised in that be made up of following components and weight ratio thereof: 10%-60% magnesium sulfate, 0.01%-5% plant extract, 0.5%-15% glycerol, 0.1%-5% ethanol, 0.5%-20% carboxymethyl cellulose Element sodium, 1%-5%PEG40-castor oil hydrogenated, surplus are purified water.

8. a medical gel wet application, it is characterised in that include the medical gel described in claim 1-7 and medical carrier, Described medical carrier is non-woven fabrics, absorbent cotton, gauze, sponge, absorbent paper one therein or its combination in any or is above-mentioned Antiseptic dressing prepared by material.

9. gel wet application as claimed in claim 8 a kind of, is characterized in that, described carrier includes two sides, away from affected part The one side of contact is coated with breathing waterproof film；Described breathing waterproof film uses polypropylene type, polyethylene kind, polyurethanes wherein A kind of or its any combination material makes.

10. prepare the preparation method of gel wet application described in claim 8-9 for one kind, it is characterised in that comprise the following steps:

(1) purified water is boiled 3-10 minute, be cooled to room temperature；

(2) take 125g-500g magnesium sulfate, add 500ml purified water and dissolve；

(3) 30ml-50ml70% ethanol, 1ml-5mlPEG40-castor oil hydrogenated and 5ml-150ml glycerol are mixed, add 1ml- 50ml plants essential oil dissolves；