CN101934015A - Traditional Chinese medicinal composition for treating thyroid and method for preparing dispelling-goitre cataplasm thereof - Google Patents
Traditional Chinese medicinal composition for treating thyroid and method for preparing dispelling-goitre cataplasm thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicinal composition for treating thyroid and a method for preparing a dispelling-goitre cataplasm thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicinal composition is mainly prepared from Chinese angelica, szechuan lovage rhizome, white mustard seed, astragalus, Chinese honeylocust spine, common selfheal fruit-spike, dioscorea bulbifera L and green tangerine peel in a certain weight ratio. The traditional Chinese medicinal composition is formed by improving the clinically effective proved recipe, namely dispelling-goitre decoction, and by preliminary observation of 28 cases through clinical oral administration, the effective rate is 82.14 percent, the dialectic treatment advantages of traditional Chinese medical science and traditional Chinese medicines in treating the diseases are shown and the defects of Western medicaments for treating the diseases are overcome.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of preparation method for the treatment of thyroid Chinese medicine composition and diffusing wart cataplasma thereof.
Background technology
The thyroid disease onset is slow, and its outstanding clinical manifestation is a thyromegaly, generally is the moderate anthorisma, and matter is tough or harder, also can be symptoms such as nodositas, has greatly influenced patient's physical and mental health.Nowadays, along with the change of rhythm of life, operating pressure strengthens and excessive iodine is taken in, and causes its sickness rate soaring year by year.Because the pathogeny of primary disease is not clear so far, has now caused the great attention of the world of medicine and relevant departments.
Chinese medicine manifests gradually in advantage aspect the treatment thyroid disease in recent years, and when the treatment thyroid disease, accumulated rich experience, and having formed the secret recipe and the proved recipe of a large amount of determined curative effects, its method of treatment has " internal treatment ", " external treatment ", " interior external treatment " and " Chinese and Western combined techniques "." external treatment " is a kind ofly to start with from taking stopgap measures, and takes into account the method for effecting a permanent cure.The thyroid external preparation relevant report of treatment is less both at home and abroad at present, even if the level that also only rests on simple diachylon and ointment is arranged, owing to there is not science of method for making, effective ingredient extracts not exclusively, the preparation drug loading is little and act on drawbacks such as not obvious, make drug absorption poor, curative effect is not obvious, and the anaphylaxis incidence rate is higher.
Summary of the invention
At the problem that prior art exists, the objective of the invention is to design provides a kind of technical scheme for the treatment of the preparation method of thyroid Chinese medicine composition and diffusing wart cataplasma thereof.
The thyroid Chinese medicine composition of described a kind of treatment is characterized in that comprising that following raw medicaments in portion by weight makes: 1～12 part on 1～30 part of Radix Angelicae Sinensis, 1～30 part of Rhizoma Chuanxiong, 1～15 part of Semen Sinapis Albae, 1～30 part of the Radix Astragali, 1～15 part of Spina Gleditsiae, 1～30 part of Spica Prunellae, 1～15 part of Dioscorea bulbifera L. and Pericarpium Citri Reticulatae Viride.
The thyroid Chinese medicine composition of described a kind of treatment is characterized in that comprising that following raw medicaments in portion by weight makes: 2～9 parts on 6～15 parts of Radix Angelicae Sinensis, 6～15 parts of Rhizoma Chuanxiongs, 3～12 parts of Semen Sinapis Albaes, 10～21 parts of the Radixs Astragali, 3～12 parts of Spina Gleditsiaes, 9～21 parts of Spica Prunellaes, 3～12 parts of Dioscorea bulbifera L.es and Pericarpium Citri Reticulatae Viride.
The thyroid Chinese medicine composition of described a kind of treatment is characterized in that comprising that following raw medicaments in portion by weight makes: 3～6 parts on 9～12 parts of Radix Angelicae Sinensis, 9～12 parts of Rhizoma Chuanxiongs, 6～9 parts of Semen Sinapis Albaes, 12～15 parts of the Radixs Astragali, 6～9 parts of Spina Gleditsiaes, 12～15 parts of Spica Prunellaes, 6～9 parts of Dioscorea bulbifera L.es and Pericarpium Citri Reticulatae Viride.
The thyroid Chinese medicine composition of described a kind of treatment, its feature is external pulvis, cataplasma or other exterior-applied formulation in the dosage form of described compositions.
Described a kind of preparation method for the treatment of the diffusing wart cataplasma of thyroid Chinese medicine composition is characterized in that comprising following processing step:
1) take by weighing each crude drug Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Sinapis Albae, the Radix Astragali, Spina Gleditsiae, Spica Prunellae, Dioscorea bulbifera L. and Pericarpium Citri Reticulatae Viride, standby;
2) in the Radix Angelicae Sinensis of described weight portion and Rhizoma Chuanxiong, add 6～10 times of ethanol and carry out reflux, extract,, extracted 1～2 hour, extract 1～3 time, merge ethanol extract and obtain extracting solution A, extracting solution A is 1.15～1.30 extractum through reclaiming ethanol to not having the alcohol flavor, being concentrated into relative density, promptly obtains extractum I; In Semen Sinapis Albae, the Radix Astragali, Spina Gleditsiae, Spica Prunellae, Dioscorea bulbifera L. and the Pericarpium Citri Reticulatae Viride of described weight portion, add 8～12 times of water, decoct 1～3 time, each 1～2 hour, merge the water extract and obtain extracting solution B, extracting solution B adds ethanol after concentrating, make and contain alcohol amount and reach 50～70%, after leaving standstill 24～48h, sucking filtration reclaims ethanol to there not being the alcohol flavor, be concentrated into relative density and be 1.15～1.30 extractum, promptly obtain extractum II; Extractum I and extractum II mix homogeneously is standby as ointment;
3) be 1～1.4: 0.35～1.8 by ointment, sticker, wetting agent, filler and Percutaneous absorption enhancer weight ratio: 1.0～2.0: 0.02～0.16: 1.0～3.0, take by weighing adjuvant, the sticker, wetting agent, filler, the Percutaneous absorption enhancer heated and stirred in 55 ℃～65 ℃ water-baths that take by weighing is even, coat on the non-woven fabrics after adding the ointment mixing and stirring again, coating thickness is 0.5mm, cover polyethylene film then, after room temperature is placed 24～72h down, specification cutting on demand promptly gets the wart cataplasma mastic finished product that looses.
Described a kind of preparation method for the treatment of the diffusing wart cataplasma of thyroid Chinese medicine composition is characterized in that described sticker is the mixture of one or more arbitrary proportions in gelatin, sodium polyacrylate, polyvinyl alcohol, carboxymethyl cellulose and sodium salt thereof, polyvinylpyrrolidone and the cellulose derivative.
Described a kind of preparation method for the treatment of the diffusing wart cataplasma of thyroid Chinese medicine composition is characterized in that described wetting agent is the mixture of one or more arbitrary proportions in glycerol, sorbitol and the Oleum Ricini.
Described a kind of preparation method for the treatment of the diffusing wart cataplasma of thyroid Chinese medicine composition is characterized in that described filler is the mixture of one or more arbitrary proportions in Kaolin, micropowder silica gel, calcium carbonate, titanium dioxide and the zinc oxide.
Described a kind of preparation method for the treatment of the diffusing wart cataplasma of thyroid Chinese medicine composition is characterized in that described Percutaneous absorption enhancer is the mixture of one or more arbitrary proportions of azone and polyhydric alcohol.
Described a kind of loose preparation method of wart cataplasma of thyroid Chinese medicine composition for the treatment of is characterized in that described step 2) in ointment, sticker, wetting agent, filler and Percutaneous absorption enhancer weight ratio be 1～1.4: 0.6～1.2: 1.5～2.0: 0.05～0.10: 1.5～2.5.
The above-mentioned thyroid Chinese medicine composition of a kind of treatment has the effect that a surname is led to nutrient blood, resolving phlegm and dissipating blood stasis, set upright the wart that disappears by Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Astragali, Semen Sinapis Albae, the Radix Astragali, Spina Gleditsiae, Spica Prunellae, Dioscorea bulbifera L., Pericarpium Citri Reticulatae Viride.Radix Angelicae Sinensis acrid in the mouth warm in nature has blood circulation promoting and blood stasis dispelling, an effect of the pain relieving of enriching blood, and Zhu Zhi mass in the abdomen knot is poly-, ulcer sores; The fragrant string of the hot temperature of Rhizoma Chuanxiong is walked and is not kept, and the gas medicine in the meaning blood can blood-activating and qi-promoting, cures mainly " the sick wart of scrofula is superfluous ", and the hot temperature of the Semen Sinapis Albae property of medicine has the loose effect of joint, removing obstruction in the collateral to relieve pain of warming the lung to resolve fluid-retention, promoting the circulation of QI, can dispel " heresy that the flesh side film is outer "; The Radix Astragali is sweet, warm, returns lung, spleen channel, has the effect of tonifying Qi and lifting yang, holder skin ulcer granulation promoting; The hot temperature of Spina Gleditsiae is returned liver, lung, stomach warp, and having eliminates the phlegm has one's ideas straightened out, the effect of mass dissipating and swelling eliminating.Spica Prunellae property of medicine hardship, suffering, cold are returned liver, gallbladder meridian, can " broken wart, the wart stagnation of QI looses ", and " mediation stagnation of QI " has the effect of the capable knot of dissipating depression of QI, clearing away liver-fire, resolving depression eliminating stagnation; Dioscorea bulbifera L. property of medicine bitter cold, slightly poisonous, return lung, Liver Channel, for controlling the wart key medicine, energy " removing heat from blood pathogenic fire reducing, the wart that disappears detoxifcation " is controlled and is disliked swollen skin ulcer tumor, goiter tuberculosis, adjuvant drug in both sides of being all; Pericarpium Citri Reticulatae Viride property of medicine hardship, Xin Wen return liver, gallbladder, stomach warp, have the effect of promoting the circulation of QI eliminating phlegm, dispersing cold for relieving pain, and priming is up.The modern pharmacological research proof Radix Astragali has potentiation to body specific cell and humoral immune function, can improve body's immunological function, defence capability and anti-tumor capacity.The bibliographical information Radix Astragali, Radix Angelicae Sinensis have the damage that alleviates oxygen-derived free radicals, and the inflammation-inhibiting factor reduces fibrogenic effect, can induce the apoptosis of thyroid cell.Ligustrazine in the Rhizoma Chuanxiong and ferulic acid have tangible antiinflammatory and analgesic activity.More than all medicine compatibilities use and can regulate body's immunity effectively, suppress the hypertrophy of parathyroid tissue.Remove this, the hot temperature of Rhizoma Chuanxiong, Radix Angelicae Sinensis Xin Ganwen, the hot temperature of Semen Sinapis Albae among the present invention, the medicine of these nature and flavor sufferings itself just has the effect that promotes Transdermal absorption as the composition of medicine of external preparation such as preparation cataplasma.The use of external plaster agent is long at Chinese history, not only is confined to treat skin and local disease, also can reach inner disease outer treat by skin." interior disease external therapy " is one of marrow of theory of Chinese medical science, also is Chinese medicine preparation capable of permeating skin development theory basis.The traditional Chinese medical science thinks that the dominant mechanism that the medicine percutaneous absorbs is that meridians conduction and skin penetrate, and the nature and flavor of this and Chinese medicine, returns through characteristics such as, effects close getting in touch arranged.Though do not have the such notion of Transdermal absorption at that time, the external plaster agent is but used till today always, illustrate that the agent of Chinese medicine compound card still has its transdermal mechanism and characteristics, is worth our to inquire into and research.Along with going deep into of research, as penetration enhancer, the research and development of cataplasma and other external preparation had certain directive significance and value in conjunction with the Chinese medicine rationale with the composition of part medicine in the prescription.
The above-mentioned thyroid Chinese medicine composition of a kind of treatment is to form through plus-minus according to clinical effective proved recipe " wart that disappears soup ", through clinical oral administration administration 28 routine preliminary observations, effective percentage reaches 82.14%, to show the advantage of Chinese medicine, remedied the deficiency (cure the symptoms, not the disease) of Western medicine in this type of disease of treatment in such disease determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of treatment.
Above-mentioned thyroid Chinese medicine composition of a kind of treatment and preparation method thereof, the rule of treatment of the employing traditional Chinese medical science " inner disease outer treat " is screened medicine, is made into " wart that disappears is loose ", " the wart cataplasma looses ".
Cataplasma is as sticking a kind of novel form of agent, " substrate is different " that are to use with the difference of the maximum of traditional black plaster of China and rubber plaster.Cataplasma have contain that dose is big, transdermal effect good, dose controllable component, good permeability, to characteristics such as the skin biocompatibility are good, non-stimulated, be ideal external used medicine transmission platform.Now become a kind of safe, comfortable topical system, and can effectively treat thyroid disease and remove patient's body and mind misery.
And the substrate described in the present invention has extensive congruent melting to compound extract, can carry the Chinese medicine of respectively distinguishing the flavor of, by the form cataplasma that good technology platform is made, have that stickiness is good, drug loading is big, good permeability, bioavailability height, zest are little, pasting comfortable, easy to use and advantage such as can use repeatedly.The clinical thyroid diseases such as simple goiter, hyperthyroidism, chronic lymphocytic thyroiditis (chronic lymphocytic thyroiditis), nodular goiter that are used for the treatment of, and can remedy the blank of state's this type of disease of internal therapy, its potential huge medical market will be developed, and the society that is produced, economic benefit are with limitless.
The specific embodiment
Further specify the present invention below in conjunction with specific embodiment.
Embodiment 1: the Chinese medicine composition of treatment thyroid disease
Prescription: Radix Angelicae Sinensis 21g, Rhizoma Chuanxiong 12g, Semen Sinapis Albae 12g, Radix Astragali 20g, Spina Gleditsiae 9g, Spica Prunellae 15g, Dioscorea bulbifera L. 9g, Pericarpium Citri Reticulatae Viride 6g, add 8 times of water gagings and decoct 2 times, each 2h merges medicinal liquid, through being concentrated into relative density is 1.15, promptly gets the Chinese medicine composition for the treatment of the thyroid disease external preparation.
Embodiment 2: the Chinese medicine composition of treatment thyroid disease
Prescription: Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 15g, Semen Sinapis Albae 9g, Radix Astragali 15g, Spina Gleditsiae 9g, Spica Prunellae 15g, Dioscorea bulbifera L. 6g, Pericarpium Citri Reticulatae Viride 3g, add 6 times of water gagings and decoct 3 times, each 1h merges medicinal liquid, through being concentrated into relative density is 1.20, promptly gets the Chinese medicine composition for the treatment of thyroid disease.
Embodiment 3: the Chinese medicine composition of treatment thyroid disease
Prescription: Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 12g, Semen Sinapis Albae 9g, Radix Astragali 15g, Spina Gleditsiae 9g, Spica Prunellae 15g, Dioscorea bulbifera L. 9g, Pericarpium Citri Reticulatae Viride 6g, with above-mentioned eight flavors, be ground into fine powder, sieve (120 order), mixing promptly gets the Chinese medicine composition for the treatment of thyroid disease.
Embodiment 4: the Chinese medicine composition of treatment thyroid disease
Prescription: Radix Angelicae Sinensis 9g, Rhizoma Chuanxiong 9g, Semen Sinapis Albae 6g, Radix Astragali 12g, Spina Gleditsiae 6g, Spica Prunellae 12g, Dioscorea bulbifera L. 9g, Pericarpium Citri Reticulatae Viride 3g, with above-mentioned eight flavors, be ground into fine powder, sieve (120 order), mixing promptly gets the Chinese medicine composition for the treatment of thyroid disease.
Embodiment 5: the Chinese medicine composition of treatment thyroid disease
Prescription: Radix Angelicae Sinensis 2g, Rhizoma Chuanxiong 2g, Semen Sinapis Albae 1g, Radix Astragali 3g, Spina Gleditsiae 2g, Spica Prunellae 5g, Dioscorea bulbifera L. 2g, Pericarpium Citri Reticulatae Viride 1g, with above-mentioned eight flavors, be ground into fine powder, sieve (120 order), mixing promptly gets the Chinese medicine composition for the treatment of thyroid disease.
Embodiment 6: the Chinese medicine composition of treatment thyroid disease
Prescription: Radix Angelicae Sinensis 21g, Rhizoma Chuanxiong 12g, add 80% concentration ethanol of 6 times of amounts, heating and refluxing extraction 2 times is extracted 2h at every turn, merges alcohol extract, reclaims ethanol, being concentrated into relative density is 1.15, extractum I; Semen Sinapis Albae 9g, Radix Astragali 20g, Spina Gleditsiae 9g, Spica Prunellae 15g, Dioscorea bulbifera L. 9g, Pericarpium Citri Reticulatae Viride 6g, the water that adds 12 times of amounts, decoct 3 times, each 1h, merging the water extract, is 1.15 through being concentrated into relative density, gets extractum II, with extractum I and extractum II mix homogeneously, promptly get the Chinese medicine composition for the treatment of thyroid disease.
Embodiment 7: the Chinese medicine composition of treatment thyroid disease
Prescription: Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 12g, add 70% concentration ethanol of 8 times of amounts, heating and refluxing extraction 2 times is extracted 1h at every turn, merges alcohol extract, reclaims ethanol, being concentrated into relative density is 1.20, extractum I; Semen Sinapis Albae 9g, Radix Astragali 15g, Spina Gleditsiae 9g, Spica Prunellae 15g, Dioscorea bulbifera L. 9g, Pericarpium Citri Reticulatae Viride 3g, the water that adds 10 times of amounts, decoct 2 times, each 1h, merging the water extract, is 1.20 through being concentrated into relative density, gets extractum II, with extractum I and extractum II mix homogeneously, promptly get the Chinese medicine composition for the treatment of the thyroid disease external preparation.
Embodiment 8: the Chinese medicine composition of treatment thyroid disease
Prescription: Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 15g, add 60% concentration ethanol of 10 times of amounts, heating and refluxing extraction 3 times, each 1h merges alcohol extract, reclaims ethanol, being concentrated into relative density is 1.30, extractum I; Semen Sinapis Albae 12g, Radix Astragali 15g, Spina Gleditsiae 9g, Spica Prunellae 15g, Dioscorea bulbifera L. 6g, Pericarpium Citri Reticulatae Viride 6g add the water of 8 times of amounts, decoct 3 times, each 1h, merge the water extract, add ethanol, make to contain pure measuring and reach 60% through concentrating the back, leave standstill 24h after, reclaim ethanol, be concentrated into relative density 1.30, obtain extractum II.With extractum I and extractum II mix homogeneously, promptly get the Chinese medicine composition for the treatment of thyroid disease.
The Chinese medicine composition of embodiment 9 treatment thyroid diseases
Prescription: Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 12g, add 70% ethanol of 8 times of amounts, heating and refluxing extraction 2 times, each 1h merges alcohol extract, reclaims ethanol, being concentrated into relative density is 1.20, extractum I; Semen Sinapis Albae 9g, Radix Astragali 15g, Spina Gleditsiae 9g, Spica Prunellae 15g, Dioscorea bulbifera L. 9g, Pericarpium Citri Reticulatae Viride 3g add 10 times of water gagings, extract 2 times, extract 1h at every turn, the water extract adds ethanol through concentrating the back, makes to contain alcohol and measure and reach 70%, leave standstill 24h after, reclaim ethanol, be concentrated into relative density 1.20, obtain extractum II.With extractum I and extractum II mix homogeneously, promptly get the Chinese medicine composition for the treatment of thyroid disease.
Embodiment 10: the Chinese medicine composition of treatment thyroid disease
Prescription: Radix Angelicae Sinensis 21g, Rhizoma Chuanxiong 12g, add 80% ethanol of 6 times of amounts, heating and refluxing extraction 3 times, each 1h merges alcohol extract, reclaims ethanol, being concentrated into relative density is 1.15, extractum I; Semen Sinapis Albae 12g, Radix Astragali 15g, Spina Gleditsiae 9g, Spica Prunellae 15g, Dioscorea bulbifera L. 6g, Pericarpium Citri Reticulatae Viride 6g add 12 times of water gagings, extract 1 time, extract 2h at every turn, the water extract adds ethanol through concentrating the back, makes to contain alcohol and measure and reach 60%, leave standstill 48h after, reclaim ethanol, being concentrated into relative density is 1.15, obtains extractum II.With extractum I and extractum II mix homogeneously, promptly get the Chinese medicine composition for the treatment of thyroid disease.
Embodiment 11: the Chinese medicine composition of treatment thyroid disease
Prescription: Radix Angelicae Sinensis 30g, Rhizoma Chuanxiong 30g, add 80% ethanol of 6 times of amounts, heating and refluxing extraction 3 times, each 1h merges alcohol extract, reclaims ethanol, being concentrated into relative density is 1.30, extractum I; Semen Sinapis Albae 6g, Radix Astragali 5g, Spina Gleditsiae 3g, Spica Prunellae 5g, Dioscorea bulbifera L. 1g, Pericarpium Citri Reticulatae Viride 2g add 12 times of water gagings, extract 2 times, extract 2h at every turn, the water extract adds ethanol through concentrating the back, makes to contain alcohol and measure and reach 50%, leave standstill 48h after, reclaim ethanol, being concentrated into relative density is 1.30, obtains extractum II.With extractum I and extractum II mix homogeneously, promptly get the Chinese medicine composition ointment for the treatment of thyroid disease.
Embodiment 12: the preparation of treatment thyroid disease Chinese medicine composition cataplasma
Get glycerol 1.0ml, propylene glycol 2ml, azone 1ml, add sodium carboxymethyl cellulose 0.1g, sodium polyacrylate 0.4g, Kaolin 0.08g, add with 3ml swollen gelatin 0.3g again, after 55 ℃ ± 1 ℃ heating in water bath stirs, add the ointment 1g that embodiment (8) makes, mixing and stirring is coated on the non-woven fabrics, thickness is 0.5mm, covers polyethylene film.After room temperature was placed 24h down, specification cutting on demand promptly got the wart cataplasma finished product that looses.
Glycerol also can adopt one or more the mixture in sorbitol or the Oleum Ricini among the embodiment 12, azone also can adopt azone, polyhydric alcohol, the mixture of one or more in azone or the polyhydric alcohol, gelatin, sodium carboxymethyl cellulose and sodium polyacrylate also can adopt gelatin, sodium polyacrylate, polyvinyl alcohol, carboxymethyl cellulose and sodium salt thereof, the mixture of one or more in polyvinylpyrrolidone or the cellulose derivative, Kaolin also can adopt mountain range soil, micropowder silica gel, calcium carbonate, the mixture of one or more in titanium dioxide or the zinc oxide also can reach at last the technique effect similar to embodiment 12.Embodiment 13: the preparation of treatment thyroid disease Chinese medicine composition cataplasma
Get glycerol 2ml, propylene glycol 1ml adds azone 1ml again, add sodium carboxymethyl cellulose 0.35g, sodium polyacrylate 0.8g, Kaolin 0.10g, and then add with behind the swollen gelatin 0.3g of 3ml, stir at 60 ℃ ± 1 heating in water bath, add the ointment 1.25g that embodiment (9) makes again, after the mixing and stirring, coat on the non-woven fabrics, thickness is 0.5mm, covers polyethylene film.After room temperature was placed 24h down, specification cutting on demand promptly got the wart cataplasma finished product that looses.
Embodiment 14: the preparation of treatment thyroid disease Chinese medicine composition cataplasma
Get glycerol 1.20ml, propylene glycol 2ml adds azone 1ml again, add sodium carboxymethyl cellulose 0.20g, sodium polyacrylate 0.5g, Kaolin 0.08g, and then add with behind the swollen gelatin 0.2g of 2ml, 65 ℃ ± 1 ℃ heating in water bath stirs, add the ointment 1.4g that embodiment (9) makes again, mix to stir and spare, coat on the non-woven fabrics, thickness is 0.5mm, covers polyethylene film.After room temperature was placed 48h down, specification cutting on demand promptly got the wart cataplasma finished product that looses.
Embodiment 15: the wart cataplasma preliminarily stabilised test of loosing
The diffusing wart cataplasma of getting embodiment 13 gained carries out the preliminarily stabilised test.
Test method: this product is put plastic bag, preserved three months, respectively after 0,1,2,3 month, by " requirement under the Chinese pharmacopoeia item is investigated every index of the wart cataplasma that looses, and the results are shown in Table 1 at room temperature condition.
The diffusing wart cataplasma preliminarily stabilised investigation test of table 1
Result according to investigation: after depositing three months under the wart cataplasma room temperature that looses, its physicochemical property and every inspection index all meet the requirements, and show the wart cataplasma steady quality that looses.
Compositions among other embodiment is carried out the experiment identical with embodiment 15, and it also can reach the technique effect similar to embodiment 15.
Embodiment 16: the wart cataplasma that looses is to rabbit intact skin irritant test
The diffusing wart cataplasma of getting embodiment 13 gained carries out rabbit intact skin irritant test.
Animal subject: experiment adult healthy rabbit body weight 3.0～3.5kg, the male and female dual-purpose is provided by Zhejiang University of Traditional Chinese Medicine zoopery center.
Test method: (1) gets 6 of healthy rabbits, is divided into 2 groups at random, 3 every group (20～25 ℃ of room temperatures, relative humidity 50～65%).Pick hair in animal spinal column both sides, administration forward position, every lateral area is about 8 * 12cm2, after confirming to pick territory, hair-fields skin zero damage, be divided into the left and right sides along every rabbit spinal column, left field is pasted the wart crust cloth cream that looses, and right side area is pasted blank plaster (excipient), and sticking area is 6 * 8cm2.
(2) the A group sticks and looses the wart cataplasma and reach blank plaster 24h (for the first time), throw off and tried thing, observe and write down 24,48 respectively, every group every animal of 72h tried the situation that skin area has or not erythema and edema, if no above-mentioned symptom occurs, paste 24h (for the second time) again, continuation observation 24,48,72h skin are tried the situation after the zone has or not erythema, edema appearance and the above-mentioned symptom recovery occurs; After the B group sticks loose wart cataplasma and blank plaster 48h (for the first time), throw off and tried thing, observe and write down 24,48 respectively, every group every animal of 72h tried the situation that skin area has or not erythema and edema, if no above-mentioned symptom occurs, paste 48h (for the second time) again, continuation observation 24,48, every group every animal skin of 72h are tried the situation that the zone has or not erythema, edema and above-mentioned symptom to recover.Independent integral separately.The results are shown in Table 2,3.
Table 2 sticks administration rabbit intact skin stimulation test result for the first time
Stick for the first time diffusing wart cataplasma cream and blank substrate cream A, B shown in the table 2 and there is no erythema and edema for two groups.
Table 3 sticks administration (the multiple subsides) rabbit intact skin stimulation test result for the second time
Shown in the table 3: stick the wart cataplasma cream that looses for the second time to rabbit intact skin nonirritant, the blank plaster minimal irritation occurs to the rabbit intact skin.
Table 4 skin irritation evaluation result
Conclusion: according to shown in the table 4: the wart of loosing crust cloth cream through stick 24 respectively, behind the 48h to rabbit intact skin stimulus intensity all＜0.5, the result shows that the wart crust cloth cream that looses is to rabbit intact skin nonirritant.
Compositions among other embodiment is carried out the experiment identical with embodiment 16, and it also can reach the technique effect similar to embodiment 16.
Embodiment 17: clinical case is observed
Liu so-and-so, the woman, 64 years old, Zhejiang Hangzhou people, conscious eyes have the sense of expanding, eye slightly prominent, the time had palpitation insomnia, neck has enlargement, tongue book, red, the red tip of the tongue of matter, stringy pulse is several slightly, moving then perspiration, flushed face, feverish sensation in the palms and soles.Lab testing T3, T4 raise, and clinical diagnosis is hyperthyroidism.The wart of loosing crust cloth patch was changed dressings once in the affected part, throat in 2-3 days, treated continuously 3 months, and lump obviously dwindles, and General Symptoms alleviates.
Embodiment 18: clinical case is observed
Wang so-and-so, the man, 30 years old, people from Yongkang, Zhejiang, the thyroid anthorisma, spiritlessness and weakness, shortness of breath and palpitation, emaciated physique, vexed spontaneous perspiration, both hands tremble, xerostomia, feel sick bilateral thyromegaly, the softness of touching, no tenderness.Lab testing T3, T4 raise, and TSH descends, and TPOAb, TGAb increase, and clinical diagnosis is that chronic lymphocytic thyroiditis merges hyperthyroidism.According to the swollen area size of wart, the cancellation wart is coated with cream and is affixed on the affected part, throat in gauze after loosing and adding an amount of water or wine and mix well, and changes once in 3 days, treats continuously 3 months, and lump dwindles 1/3, and General Symptoms alleviates.
Embodiment 19: clinical case is observed
Zhang, the woman, 38 years old, people from Taizhou, Zhejiang, the enlargement of clinical manifestation cervical region lobus lateralis dexter, with an oval tuberosity, smooth surface, with swallow do up and down, weak, the soreness of waist, throat has sense of obstruction, tongue fur book, stringy and thready pulse.Lab testing T3, T4 are normal, and TSH slightly raises, and TPOAb, TGAb increase, and clinical diagnosis is a chronic lymphocytic thyroiditis companion tuberosity.The wart cataplasma that looses is affixed on the affected part, throat, changes once in 2-3 days, treats continuously 3 months, and lump obviously dwindles, and General Symptoms obviously alleviates.
Embodiment 20: clinical case is observed
The pond so-and-so, the woman, 53 years old, Zhejiang Hangzhou people, cervical region is enlargement gradually, when swallowing sense uncomfortable, being irritable and getting angry easily sometimes, idol has nervous, the food of receiving is general, the both sides tuberosity of all can laying one's hand on and differ in size, stringy,thready and rapid pulse, red tongue, white and thin fur.Lab testing T3, T4 are normal, and TSH slightly descends, and clinical diagnosis is a nodular goiter.The wart of loosing is affixed on the affected part, throat after loosing and mixing well, and changes dressings once in 3 days, takes Chinese medicine simultaneously, treats the 3-4 month continuously, and lump obviously dwindles, and General Symptoms alleviates.
Embodiment 21: clinical case is observed
Flood so-and-so, the woman, 51 years old, Zhejiang Hangzhou people, poke, no tenderness, matter are tough, tuberosity can move up and down with swallowing, lab testing T3, T4 decline, TSH is high slightly, TPOAb, TGAb increase, clinical diagnosis is a chronic lymphocytic thyroiditis.The wart of loosing crust cloth patch was changed dressings once in the affected part, throat in 2-3 days, took Euthyrox simultaneously, treated continuously 3 months, and lump obviously dwindles, and General Symptoms alleviates.
Claims (10)
1. thyroid Chinese medicine composition of treatment is characterized in that comprising that following raw medicaments in portion by weight makes: 1～12 part on 1～30 part of Radix Angelicae Sinensis, 1～30 part of Rhizoma Chuanxiong, 1～15 part of Semen Sinapis Albae, 1～30 part of the Radix Astragali, 1～15 part of Spina Gleditsiae, 1～30 part of Spica Prunellae, 1～15 part of Dioscorea bulbifera L. and Pericarpium Citri Reticulatae Viride.
2. the thyroid Chinese medicine composition of a kind of treatment as claimed in claim 1 is characterized in that comprising that following raw medicaments in portion by weight makes: 2～9 parts on 6～15 parts of Radix Angelicae Sinensis, 6～15 parts of Rhizoma Chuanxiongs, 3～12 parts of Semen Sinapis Albaes, 10～21 parts of the Radixs Astragali, 3～12 parts of Spina Gleditsiaes, 9～21 parts of Spica Prunellaes, 3～12 parts of Dioscorea bulbifera L.es and Pericarpium Citri Reticulatae Viride.
3. the thyroid Chinese medicine composition of a kind of treatment as claimed in claim 1 is characterized in that comprising that following raw medicaments in portion by weight makes: 3～6 parts on 9～12 parts of Radix Angelicae Sinensis, 9～12 parts of Rhizoma Chuanxiongs, 6～9 parts of Semen Sinapis Albaes, 12～15 parts of the Radixs Astragali, 6～9 parts of Spina Gleditsiaes, 12～15 parts of Spica Prunellaes, 6～9 parts of Dioscorea bulbifera L.es and Pericarpium Citri Reticulatae Viride.
4. the thyroid Chinese medicine composition of a kind of treatment as claimed in claim 1, its feature is external pulvis, cataplasma or other exterior-applied formulation in the dosage form of described compositions.
5. as claim 1 or 2 or 3 described a kind of preparation methoies for the treatment of the diffusing wart cataplasma of thyroid Chinese medicine composition, it is characterized in that comprising following processing step:
1) take by weighing each crude drug Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Sinapis Albae, the Radix Astragali, Spina Gleditsiae, Spica Prunellae, Dioscorea bulbifera L. and Pericarpium Citri Reticulatae Viride, standby;
2) in the Radix Angelicae Sinensis of described weight portion and Rhizoma Chuanxiong, add 6～10 times of ethanol and carry out reflux, extract,, extracted 1～2 hour, extract 1～3 time, merge ethanol extract and obtain extracting solution A, extracting solution A is 1.15～1.30 extractum through reclaiming ethanol to not having the alcohol flavor, being concentrated into relative density, promptly obtains extractum I; In Semen Sinapis Albae, the Radix Astragali, Spina Gleditsiae, Spica Prunellae, Dioscorea bulbifera L. and the Pericarpium Citri Reticulatae Viride of described weight portion, add 8～12 times of water, decoct 1～3 time, each 1～2 hour, merge the water extract and obtain extracting solution B, extracting solution B adds ethanol after concentrating, make and contain alcohol amount and reach 50～70%, after leaving standstill 24～48h, sucking filtration reclaims ethanol to there not being the alcohol flavor, be concentrated into relative density and be 1.15～1.30 extractum, promptly obtain extractum II; Extractum I and extractum II mix homogeneously is standby as ointment;
3) be 1～1.4: 0.35～1.8 by ointment, sticker, wetting agent, filler and Percutaneous absorption enhancer weight ratio: 1.0～2.00: 0.02～0.16: 1.0～3.0, take by weighing adjuvant, the sticker, wetting agent, filler, the Percutaneous absorption enhancer heated and stirred in 55 ℃～65 ℃ water-baths that take by weighing is even, coat on the non-woven fabrics after adding the ointment mixing and stirring again, coating thickness is 0.5mm, cover polyethylene film then, after room temperature is placed 24～72h down, specification cutting on demand promptly gets the wart cataplasma mastic finished product that looses.
6. a kind of preparation method for the treatment of the diffusing wart cataplasma of thyroid Chinese medicine composition as claimed in claim 5 is characterized in that described sticker is the mixture of one or more arbitrary proportions in gelatin, sodium polyacrylate, polyvinyl alcohol, carboxymethyl cellulose and sodium salt thereof, polyvinylpyrrolidone and the cellulose derivative.
7. a kind of preparation method for the treatment of the diffusing wart cataplasma of thyroid Chinese medicine composition as claimed in claim 5 is characterized in that described wetting agent is the mixture of one or more arbitrary proportions in glycerol, sorbitol and the Oleum Ricini.
8. a kind of preparation method for the treatment of the diffusing wart cataplasma of thyroid Chinese medicine composition as claimed in claim 5 is characterized in that described filler is the mixture of one or more arbitrary proportions in Kaolin, micropowder silica gel, calcium carbonate, titanium dioxide and the zinc oxide.
9. a kind of preparation method for the treatment of the diffusing wart cataplasma of thyroid Chinese medicine composition as claimed in claim 5 is characterized in that described Percutaneous absorption enhancer is the mixture of one or more arbitrary proportions of azone and polyhydric alcohol.
10. a kind of loose preparation method of wart cataplasma of thyroid Chinese medicine composition for the treatment of as claimed in claim 5 is characterized in that described step 2) in ointment, sticker, wetting agent, filler and Percutaneous absorption enhancer weight ratio be 1～1.4: 0.6～1.2: 1.5～2.0: 0.05～0.10: 1.5～2.5.
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|---|---|---|---|---|
| CN102727688A (en) * | 2012-07-09 | 2012-10-17 | 姜占义 | Application of Chinagreen herb in preparation of medicament for treating thyroid and tincture |
| CN103479768A (en) * | 2013-09-16 | 2014-01-01 | 青岛市市立医院 | Composite traditional Chinese medicine compound for treating chronic lymphocytic thyroiditis |
| CN105031506A (en) * | 2015-03-27 | 2015-11-11 | 上海市中医医院 | Appetizing cataplasma and preparation method of same |
| CN105943812A (en) * | 2016-06-28 | 2016-09-21 | 杨大妹 | Traditional Chinese medicine for treating qi goiter and manufacturing method thereof |
| CN114306206A (en) * | 2021-12-28 | 2022-04-12 | 苏州市中医医院 | External traditional Chinese medicine composition for treating thyroid nodule and preparation method and application of external traditional Chinese medicine gel plaster |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709288A (en) * | 2004-06-17 | 2005-12-21 | 成都地奥制药集团有限公司 | Medicinal composition, and its preparing method and use |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709288A (en) * | 2004-06-17 | 2005-12-21 | 成都地奥制药集团有限公司 | Medicinal composition, and its preparing method and use |
Non-Patent Citations (2)
| Title |
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| 《民族医药报》 20090501 范瑛 白芥子药用小方 第1页 1-10 , 2 * |
| 《河南中医》 20090131 裴晓华等 近10年桥本氏甲状腺炎中医辨证分型及中西医结合治疗进展 第97-99页 1-10 第29卷, 第1期 2 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727688A (en) * | 2012-07-09 | 2012-10-17 | 姜占义 | Application of Chinagreen herb in preparation of medicament for treating thyroid and tincture |
| CN102727688B (en) * | 2012-07-09 | 2014-05-14 | 姜占义 | Application of Chinagreen herb in preparation of medicament for treating thyroid and tincture |
| CN103479768A (en) * | 2013-09-16 | 2014-01-01 | 青岛市市立医院 | Composite traditional Chinese medicine compound for treating chronic lymphocytic thyroiditis |
| CN105031506A (en) * | 2015-03-27 | 2015-11-11 | 上海市中医医院 | Appetizing cataplasma and preparation method of same |
| CN105943812A (en) * | 2016-06-28 | 2016-09-21 | 杨大妹 | Traditional Chinese medicine for treating qi goiter and manufacturing method thereof |
| CN114306206A (en) * | 2021-12-28 | 2022-04-12 | 苏州市中医医院 | External traditional Chinese medicine composition for treating thyroid nodule and preparation method and application of external traditional Chinese medicine gel plaster |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101934015B (en) | 2012-05-16 |
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