CN102580030B - External traditional Chinese medicine composition having effect of reducing blood sugar, preparation prepared from the external traditional Chinese medicine composition, and their preparation method - Google Patents
External traditional Chinese medicine composition having effect of reducing blood sugar, preparation prepared from the external traditional Chinese medicine composition, and their preparation method Download PDFInfo
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Abstract
The invention discloses an external traditional Chinese medicine composition having an effect of reducing blood sugar, a preparation prepared from the external traditional Chinese medicine composition, and their preparation method. The external traditional Chinese medicine composition having an effect of reducing blood sugar comprises: by weight, 1 to 6 parts of cassia bark, 1 to 5 parts of dry ginger, 2 to 8 parts of suncured ginseng, 2 to 8 parts of dendrobium, 2 to 12 parts of rhizoma atractylodis, 1 to 5 parts of fructus evodiae, 1 to 5 parts of fructus amomi, 1 to 3 parts of clove, and 1 to 3 parts of semen brassicae. Through external use, the preparation prepared from the external traditional Chinese medicine composition can produce good effects of reducing blood sugar, and solves the problem that the existing western medicine and the existing traditional Chinese medicine for treating diabetes are metabolized by the liver thus producing the damage on a human body. A result of a clinical test shows that through combining oral hypoglycemic western medicines or insulin injections, the preparation prepared from the external traditional Chinese medicine composition can effectively reduce a use amount of a western medicine, gradually produces effects of reducing blood sugar and a use amount of a western medicine, is safe and reliable, and reduces the western medicine dependence of patients.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of have the Chinese medicine composition that reduces the blood glucose effect, preparation and preparation method thereof.
Background technology
diabetes (diabetes) are by inherited genetic factors, immunologic function disorder, infected by microbes and toxin thereof, the free radical toxin, the various virulence factors of Nervous and Mental Factors etc. act on body and cause hypoinsulinism, insulin resistant etc. and the sugar that causes, protein, fat, a series of metabolism disorder syndromes such as power and water Xie Zhi, clinically take hyperglycemia as main feature, polyuria can appear in model case, polydipsia, polyphagia, the performance such as become thin, i.e. " three-many-one-little " symptom, diabetes (blood glucose) cause complication in case control bad meeting, cause kidney, eye, the exhaustion pathological changes at the positions such as foot, and can't cure.
At present diabetes prevalence grows with each passing day, and is mainly insulin injection or oral promotion insulin secretion and the medicine that reduces insulin resistant for the treatment of diabetics.Doctor trained in Western medicine insulin and integrative therapy diabetes respectively have length, are that secondary lost efficacy though simple western medicine treatment has easy drug resistance, and the side effect such as stomach discomfort, erythra because its hypoglycemic effect is rapid, is convenient to take or uses and taken like a shot by the patient.Simple treatment by Chinese herbs, though have no adverse reaction, and can control the generation of clinical symptoms and complication, but blood sugar reducing function is slow, and dynamics is less, only therapy of combining Chinese and Western medicine, both can improve clinical symptoms, prevent and treat complication, and can avoid again the untoward reaction of medicine and secondary to lose efficacy.
Therefore, can be combined with Western medicine and have no adverse reaction at present and eutherapeutic Chinese medicine preparation is the focus that those skilled in the art study.But oral Preparation absorbs liver metabolism through gastrointestinal, all more or less has certain toxic and side effects, so eutherapeutic external preparation is inventor's research emphasis.
Summary of the invention
The object of the invention is to propose a kind of can the associating with Western medicine use or use, have the external medicine composition of effect of lowering blood sugar.
The second purpose of the present invention is to propose preparation method and the most preferred dosage form of above-mentioned Chinese medicine composition.
The first inventor Zhang Runqi doctor of the present invention four more than ten years of taking up a job as a doctor, both get the self-passing on of famous doctor of Chinese Medicine Li Zheng at the beginning of taking part in Taoism,, essence eager to learn because of its natural endowment is diligent tireless, and deeply be subjected to liking of name among the people traditional Chinese medical science doctor Su Zhixuan (" reviving one time " doctor Lao Su that common people's public praise is told from mouth to mouth with approbation), and formally receive and be disciple, from then on master and apprentice two people are together morning and night, learn and pass on the art industry, moral becomes skill essence, and teacher people and clay figurine are not doublely got the chief.Zhang Runqi doctor has made creative contribution in R﹠D process of the present invention, after doctor Zhang Runqi was dead in 2011, Zhao chief physician of China-Japan Friendship Hospital east doctor further arranges on the basis of initial research of the present invention, research and improvement, made up the deficiency of original formulation, draw final scheme of the present invention, thereby produce brand-new exterior-applied formulation, make the patient can break away from the misery of the side effect of taking medicine, alleviate the dependence of orally-taken blood sugar reducing medicine, and the Long-term Oral hypoglycemic medicine damages the probability that health causes, reach progressively blood sugar lowering and make its purpose of rehabilitation gradually of auxiliary patient.Zhao east doctor is engaged in tcm clinical research more than 20 year, and Senile disease is had its original opinion, is good at the senile cardiovascular and cerebrovascular disease for the treatment of and diabetes, and is particularly quite effective aspect TCM Treatment of Diabetes.
The present invention selects Cortex Cinnamomi, Rhizoma Zingiberis, Radix Ginseng, Herba Dendrobii, Rhizoma Atractylodis, Fructus Evodiae, Fructus Amomi, Flos Caryophylli, Semen Sinapis Albae nine flavor medicine combinations, is prepared into external preparation and can plays hypoglycemic effect, unites result of use more with Western medicine.The effect of the described medicine of respectively distinguishing the flavor of is as follows:
Cortex Cinnamomi: extremely hot in nature, acrid in the mouth, sweet.Gui Jing: return kidney, spleen, the heart, Liver Channel.Function: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, the cold extremities faint pulse, the YANG-depletion collapse, stomachache is had loose bowels, the colic of cold type renal mass, chills and pain of the waist and kness, the amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.
Rhizoma Zingiberis: be the dry rhizome of zingiber Zingiber officinale Rosc..Nature and flavor are hot, and are hot in nature.Return spleen, stomach, the heart, lung meridian.Effect: warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.
Radix Ginseng: practise title " Rhizoma Zingiberis Recens is sun-dried ", dig out clean drying in ground, be " Radix Ginseng "; The source is the dry root of Araliaceae Radix Ginseng Panax ginseng C.A.Mey..Can be used for that weak body and prostration, dyspnea with shortness of breath, spontaneous perspiration limb are cool, tired mind, lack of appetite and vomiting, dyspnea due to deficiency of vital energy or chronic cough, thirst due to body fluid deficiency, insomnia and dreamful sleep, palpitation with fear are forgetful, the disease of sexual impotence, frequent micturition, all qi-blood-body fluid deficiencies.
Herba Dendrobii: another name: Herba Dendrobii, Shi Lan, bracketplant, Dendrobium nobile, maple bean.Nature and flavor are sweet, cold nature.The energy replenishing YIN and removing heat, reinforcing stomach reg fluid.
Rhizoma Atractylodis: nature and flavor are hot, bitter, temperature.Return spleen, stomach, Liver Channel.Be used for distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Main the spleen and stomach being stranded by dampness; The asthenia drowsiness; Born of the same parents' painful abdominal mass abdominal distention; Inappetence; Tell and have loose bowels; Phlegm retention.
Fructus Evodiae: another name: Koji, volt spicy, peppery, the smelly lake of tea.Hot in nature, acrid in the mouth, hardship.Function: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.Be used for headache, colic, beriberi, dysmenorrhea, abdominal distention, vomiting acid regurgitation, aphtha.
Fructus Amomi: nature and flavor: acrid in the mouth, warm in nature.Return spleen channel, stomach warp, kidney channel.Function: the removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive.Cure mainly: be used for turbid damp obstructing in middle-JIAO, the gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Flos Caryophylli: property is hot, temperature.Enter stomach, spleen, kidney channel.Cure mainly: control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, ringworm.
Semen Sinapis Albae: another name: hot food.Nature and flavor are hot, heat.Enter meridian of Hand-TAI YIN.Function: warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving.Cure mainly: be used for cold-phlegm and breath with cough, distending pain in the chest and hypochondrium, the stagnant meridians of expectorant, joint numbness, pain, phlegm-damp oozing in the body, carbuncle of yin nature toxic swelling.
In order to realize purpose of the present invention, the present invention adopts following concrete technical scheme:
A kind of external medicine composition with effect of lowering blood sugar, described Chinese medicine composition is made by the crude drug of following weight parts proportioning:
Cortex Cinnamomi 1-6 part, Rhizoma Zingiberis 1-5 part, Radix Ginseng 2-8 part, Herba Dendrobii 2-8 part, Rhizoma Atractylodis 2-12 part, Fructus Evodiae 1-5 part, Fructus Amomi 1-5 part, Flos Caryophylli 1-3 part, Semen Sinapis Albae 1-3 part.
Each crude drug optimum weight part proportioning of described Chinese medicine composition is:
2 parts of Cortex Cinnamomis, 1 part of Rhizoma Zingiberis, 2 parts of Radix Ginseng, 2 parts of Herba Dendrobiis, 2 parts of Rhizoma Atractylodis, 1 part of Fructus Evodiae, 2 parts of Fructus Amomis, 2 parts of Flos Caryophyllis, 2 parts of Semen Sinapis Albaes.
A kind of external application Chinese medicine extract with effect of lowering blood sugar, described extract are extracted through conventional Traditional Chinese medicine extraction method by described Chinese medicine composition and obtain.
The purposes of described Chinese medicine extract in preparation blood sugar lowering Chinese medicine for outer use.
A kind of Chinese medicine for outer use with effect of lowering blood sugar, described Chinese medicine preparation is made by acceptable adjuvant on described Chinese medicine composition and pharmaceutics.
Described Chinese medicine for outer use is external pulvis or emplastrum.
A kind of method for preparing described Chinese medicine composition, described method step is as follows:
(1) take each crude drug according to above-mentioned consumption, standby;
(2) each crude drug is dried, mixed grinding is crossed the 100-200 mesh sieve to Powdered;
(3) packing gets final product.
Cross 100 mesh sieves in described step (2).
What described method prepared is external pulvis.
The using method that external pulvis of the present invention is recommended is: the SHENQUE acupoint of applying ointment or plaster, be about to outside the present invention the medical non-woven cloth bag of packing into powder 10g-15g, and non-woven bag directly is applied to around umbilicus, suitably to be fixed, use continuously more than 12 hours every day.
Formulation principle of the present invention and use principle:
Chinese medicine is attached great importance to the umbilicus position of human body, claims that it is " Shenque ".Shenque has another name called: " umbilical cord ", Qizhong, Qishe, Huan Gu, dimension meeting are commonly called as " navel "." can first science of acupuncture and moxibustion " says when explaining its physiological location, characteristic: the Shenque person, god's house is in wherein also, on sky section, in be people section; Umbilicus occupies the center, and is as the rank of nobility of door, magic congenital.God falls because of it in person up and down, the middle part of left and right, is " the vertical utmost point between two parties ", is total pivot that ascending or descending movement of vital Qi is come in and gone out, so can divide pure and impure and other negative and positive, excites generation and the operation of internal organs passages through which vital energy circulates QI and blood.Dissect Epidemiological Analysis from the modern times: umbilical part is near the abdominal cavity, and skin is thinner tender, and neural blood vessel is abundant has that sensitivity is high, penetration strong, absorb the characteristics such as fast.Umbilicus is the last closed place of stomach wall in embryo development procedure, and horny layer of epidermis is the thinnest, and barrier function is relatively poor, and fat-free mass under umbilicus, and the skin fascia directly is connected with peritoneum, therefore penetration is strong.The present invention utilizes ten medicines to carry out being prepared into after compatibility external pulvis or emplastrum to be used for the umbilicus position, to absorb administration through skin.
Beneficial effect of the present invention:
Preparation external of the present invention has good effect of lowering blood sugar, and has overcome the Western medicine of existing treatment diabetes and the infringement that Chinese medicine causes human body through liver metabolism.And draw through clinical verification, the present invention unites the Therapeutic Method of doctor trained in Western medicine oral antidiabetic drug or injection of insulin administration, can effectively reduce the Western medicine consumption, plays the effect that subtracts gradually the medicine blood sugar lowering, and the present invention is safe and reliable, has alleviated the drug dependence of patient to Western medicine.
The specific embodiment
The present embodiment medical material used all can available from Chinese Medicinal Materials Co, meet 2005 editions ministerial standards of Pharmacopoeia of People's Republic of China.
The preparation of embodiment 1 external pulvis of the present invention
(1) take each crude drug according to following proportioning, standby;
Cortex Cinnamomi 2g, Rhizoma Zingiberis 1g, Radix Ginseng 2g, Herba Dendrobii 2g, Rhizoma Atractylodis 2g, Fructus Evodiae 1g, Fructus Amomi 2g, Flos Caryophylli 2g, Semen Sinapis Albae 2g.
(2) each crude drug is dried, mixed grinding is crossed 100 mesh sieves to Powdered;
(3) packing gets final product.
The preparation of embodiment 2 external pulvis of the present invention
(1) take each crude drug according to following proportioning, standby;
Cortex Cinnamomi 1g, Rhizoma Zingiberis 5g, Radix Ginseng 4g, Herba Dendrobii 6g, Rhizoma Atractylodis 8g, Fructus Evodiae 5g, Fructus Amomi 1g, Flos Caryophylli 3g, Semen Sinapis Albae 1g.
(2) each crude drug is dried, mixed grinding is crossed 200 mesh sieves to Powdered;
(3) packing gets final product.
The preparation of embodiment 3 external pulvis of the present invention
(1) take each crude drug according to following proportioning, standby;
Cortex Cinnamomi 6g, Rhizoma Zingiberis 3g, Radix Ginseng 8g, Herba Dendrobii 8g, Rhizoma Atractylodis 12g, Fructus Evodiae 2g, Fructus Amomi 5g, Flos Caryophylli 1g, Semen Sinapis Albae 3g.
(2) each crude drug is dried, mixed grinding is crossed 200 mesh sieves to Powdered;
(3) packing gets final product.
The preparation of embodiment 4 emplastrumes of the present invention
Preparation method:
Press following consumption weighting raw materials standby, add the alcohol reflux of 50%-90%, reclaim extracting solution, cross 120 order stainless steel sifts and filter; Be 0.07～0.08Mpa in vacuum, temperature 70 C is with extracting solution simmer down to thick paste; Drying makes dry extract; Pulverize, cross 100 mesh sieves, make active component of the present invention; Get rubber, clean, at 50～60 ℃ of heat dryings or dry, be cut into bulk, plasticating in rubber mixing machine reticulates thin slice, eliminates static after 18～24 hours, be dipped in appropriate gasoline, move to after swelling in adhesive supplier, stir evenly, gradation adds vaseline, lanoline, zinc oxide and Colophonium etc. to make substrate, then adds medicine activity component of the present invention etc., stirs evenly, be coated with cream, the lid lining, section namely makes finished product.
Crude drug and consumption:
Cortex Cinnamomi 2g, Rhizoma Zingiberis 1g, Radix Ginseng 2g, Herba Dendrobii 2g, Rhizoma Atractylodis 2g, Fructus Evodiae 1g, Fructus Amomi 2g, Flos Caryophylli 2g, Semen Sinapis Albae 2g.
Clinical trial of the present invention and result
Clinical data:
1.1 material
Observe altogether 30 routine cases, be the traditional Chinese medical science Diabetes Clinic patient of the court.Male's 12 examples wherein, women's 18 examples, year at age (40～70), the course of disease (6～20) year.
1.2 diagnostic criteria
Western medicine diagnose standard reference World Health Organization (WHO) (WHO) expert consulting report: fasting glucose 〉=7.0mmol/L in 1999; Or the rear 2h blood glucose 〉=11.1mmol/L of clothes sugar in carbohydrate tolerance test; Or the patient of random blood sugar 〉=11.1mmol/L enters the anthology experiment.
1.3 Therapeutic Method
All cases is up to standard according to conventional hypoglycemic medicine (oral antidiabetic drug acarbose, metformin hydrochloride, Gliclazide sustained-release tablet and/or insulin) the control blood glucose that uses of blood sugar level.Continue conventional Western medicine glucose-lowering treatment during treatment, the external pulvis of the dual-purpose embodiment of the present invention 1 preparation is packed into and is sticked umbilicus, 24 hours (or being no less than 12 hours every day) in non-woven bag.
1.4 judgment criteria
Effectively: orally-taken blood sugar reducing dose or insulin injection amount reduce, and glycemic control is steady.
Invalid: orally-taken blood sugar reducing dose or insulin injection amount reduce, blood sugar increasing.Or glycemic control is stable, but orally-taken blood sugar reducing dose or insulin injection amount are unchanged.
1.5 observation of curative effect
After testing 1 month, oral antidiabetic drug or insulin injection glucose-lowering treatment person are under the glycemic control good situations, medication decrement person reaches 24 people, effective percentage reaches 80%, rapid-action, one month namely effective in cure, illustrates that the present invention and Western medicine are united to use when good effect of lowering blood sugar is arranged, reduce the consumption of oral western medicine, avoided infringement and other side effect to the human liver.
Claims (9)
1. the external medicine composition with effect of lowering blood sugar, is characterized in that, described Chinese medicine composition is made by the crude drug of following weight parts proportioning:
Cortex Cinnamomi 1-6 part, Rhizoma Zingiberis 1-5 part, Radix Ginseng 2-8 part, Herba Dendrobii 2-8 part, Rhizoma Atractylodis 2-12 part, Fructus Evodiae 1-5 part, Fructus Amomi 1-5 part, Flos Caryophylli 1-3 part, Semen Sinapis Albae 1-3 part.
2. the external medicine composition with effect of lowering blood sugar according to claim 1, is characterized in that, described Chinese medicine composition is made by the crude drug of following weight parts proportioning:
2 parts of Cortex Cinnamomis, 1 part of Rhizoma Zingiberis, 2 parts of Radix Ginseng, 2 parts of Herba Dendrobiis, 2 parts of Rhizoma Atractylodis, 1 part of Fructus Evodiae, 2 parts of Fructus Amomis, 2 parts of Flos Caryophyllis, 2 parts of Semen Sinapis Albaes.
3. the external application Chinese medicine extract with effect of lowering blood sugar, is characterized in that, described extract is extracted through conventional Traditional Chinese medicine extraction method by the described Chinese medicine composition of claim 1 or 2 and obtains.
4. the purposes of Chinese medicine extract claimed in claim 3 in preparation blood sugar lowering Chinese medicine for outer use.
5. the Chinese medicine for outer use with effect of lowering blood sugar, is characterized in that, described Chinese medicine preparation is made by acceptable adjuvant on the described Chinese medicine composition of claim 1 or 2 and pharmaceutics.
6. Chinese medicine preparation according to claim 5, is characterized in that, described Chinese medicine for outer use is external pulvis or emplastrum.
7. a method for preparing claim 1 or 2 described Chinese medicine composition, is characterized in that, described method step is as follows:
(1) take each crude drug according to claim 1 or 2, standby;
(2) each crude drug is dried, mixed grinding is crossed the 100-200 mesh sieve to Powdered;
(3) packing gets final product.
8. method according to claim 7, is characterized in that, crosses 100 mesh sieves in described step (2).
9. method according to claim 8, is characterized in that, what described method prepared is external pulvis.
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Families Citing this family (3)
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| CN104873949A (en) * | 2015-06-19 | 2015-09-02 | 济南邦文医药科技有限公司 | Traditional Chinese medicine for treating old dampness accumulation pattern diabetic foot ulcer |
| CN105079660A (en) * | 2015-09-21 | 2015-11-25 | 蒋丁贵 | Traditional Chinese medicine for treating diabetes and preparation method thereof |
| CN107184838A (en) * | 2017-06-06 | 2017-09-22 | 合肥先智商贸有限责任公司 | A kind of Chinese medicine preparation with effect of lowering blood sugar and preparation method thereof |
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