CN103479768A - Composite traditional Chinese medicine compound for treating chronic lymphocytic thyroiditis - Google Patents
Composite traditional Chinese medicine compound for treating chronic lymphocytic thyroiditis Download PDFInfo
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Abstract
The invention relates to a composite traditional Chinese medicine compound for treating chronic lymphocytic thyroiditis. The composite traditional Chinese medicine compound for treating the chronic lymphocytic thyroiditis is prepared from, by weight, 20-40 parts of radix scutellariae, 5-25 parts of codonopsis pilosula, 5-25 parts of angelica sinensis, 3-20 parts of ligusticum wallichii, 5-25 parts of prunella vulgaris, 10-30 parts of radix bupleuri, 10-30 parts of poria cocos, 2-25 parts of herba epimedii, 5-25 parts of citrusgrandis osbeckvar, 5-25 parts of fructus aurantii, 5-20 parts of dried tangerine or orange peel and 3-9 parts of honey-fried licorice roots. The composite traditional Chinese medicine compound for treating the chronic lymphocytic thyroiditis is low in price and definite in curative effect and has the advantages of being short in treatment course and good in curative effect and taking effect rapidly due to reasonable compatibility of effective components and auxiliary components and mutual complementation and coordination of effects. The composite traditional Chinese medicine compound is prepared from pure natural crude drugs through compatibility, can not generate side effects, dependency or drug resistance and is widely applied to prevention, control and treatment of the chronic lymphocytic thyroiditis.
Description
Technical field
The present invention relates to a kind of herbal mixture compositions for the treatment of chronic lymphocytic thyroiditis.
Background technology
Chronic lymphocytic thyroiditis claims again (the Hashimoto thyroiditis of chronic lymphocytic thyroiditis, HT), it is a kind of organ specificity autoimmune disease that clear and definite genetic predisposition is arranged, primary disease belongs to Thyroid Structure by large amount lymphocyte, plasmocyte infiltrating, the folliculus atrophy, connective tissue proliferation, subsequently mostly with hypothyroid a kind of disease.The clinical manifestations such as caking enlargement appear in Chinese medicine according to this Adam's apple both sides, disease throat, it is belonged to the category of " goiter "; Also according to primary disease, the clinical manifestation of hypothyroidism occurs and it is belonged to " asthenia ", " edema " category late period.When it is developed to hypothyroidism, obvious deficiency of spleen-YANG and kidneyYANG symptom can be arranged again during the phase, now it can be belonged to again to the category of " asthenia ".
Nearly 20～30 years, data at home and abroad prompting autoimmune thyroid disease (autoimmune thyroid diseases, AITD) morbidity has the trend of increasing, sickness rate in the crowd can be up to 22.5/10 ten thousand～40.7/10 ten thousand, account for 10% of thyroid disease at western countries HT, at China's proportion, be 3% left and right, and the sickness rate in the women it is 7 times of the male.The reason increased about sickness rate changes relevant, especially relevant with excessive iodine with environmental factors.Western medical treatment is for the treatment of HT, the methods that adopt the levothyrocine replacement therapy more, yet adopt the asthenia of the some patients were of this Therapeutic Method, weak, cardio palmus shape not to have clear improvement, and the rich iodine composition such as many Thallus Laminariae (Thallus Eckloniae)s in the prescription of traditional treatment " goiter ", though its goiter caused for iodine deficiency is effective, likely cause the patient of HT sub-clinical state to develop into clinical state.
Summary of the invention
The technical problem to be solved in the present invention is the above-mentioned defect that how to overcome prior art, and a kind of herbal mixture compositions for the treatment of chronic lymphocytic thyroiditis is provided
For solving the problems of the technologies described above, the herbal mixture compositions of this treatment chronic lymphocytic thyroiditis by following component according to shown in the weight ratio scope formulated, 20～40 parts of Radix Astragali, 5～25 parts of Radix Codonopsis, 5～25 parts of Radix Angelicae Sinensis, 3～20 parts of Rhizoma Chuanxiongs, 5～25 parts of Spica Prunellaes, 10～30 parts of Radix Bupleuri, 10～30 parts, Poria, 5～25 parts of Herba Epimedii, 5～25 parts of Exocarpium Citri Rubrums, 5～25 parts of Fructus Aurantiis, 5～20 parts of Pericarpium Citri Reticulataes, 3～9 parts of Radix Glycyrrhizae Preparatas.
As optimum ratio, described herbal mixture compositions by following component according to shown in the weight ratio scope formulated, 28～32 parts of Radix Astragali, 13～17 parts of Radix Codonopsis, 13～17 parts of Radix Angelicae Sinensis, 8～12 parts of Rhizoma Chuanxiongs, 13～17 parts of Spica Prunellaes, 10～14 parts of Radix Bupleuri, 10～14 parts, Poria, 8～12 parts of Herba Epimedii, 8～12 parts of Exocarpium Citri Rubrums, 8～12 parts of Fructus Aurantiis, 7～11 parts of Pericarpium Citri Reticulataes, 4～8 parts of Radix Glycyrrhizae Preparatas.
As best proportioning, described herbal mixture compositions by following component according to shown in the weight ratio scope formulated, 30 parts of Radix Astragali, 15 parts of Radix Codonopsis, 15 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 15 parts of Spica Prunellaes, 12 parts of Radix Bupleuri, 12 parts, Poria, 10 parts of Herba Epimedii, 10 parts of Exocarpium Citri Rubrums, 10 parts of Fructus Aurantiis, 9 parts of Pericarpium Citri Reticulataes, 6 parts of Radix Glycyrrhizae Preparatas.
As concrete best proportioning, single pair of formula of described herbal mixture compositions is, Radix Astragali 30g, Radix Codonopsis 15g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 10g, Spica Prunellae 15g, Radix Bupleuri 12g, Poria 12g, Herba Epimedii 10g, Exocarpium Citri Rubrum 10g, Fructus Aurantii 10g, Pericarpium Citri Reticulatae 9g, Radix Glycyrrhizae Preparata 6g.
As optimization, this its decoction comprises the following steps,
Step 1): 500mL water is added in the mixing Chinese medicine of drawing materials by concrete best proportioning, first with intense fire, boil, then boil 15 minutes with slow fire, use filtered through gauze;
Step 2): 250mL water is added in the medicinal residues of step 1) gained, first with intense fire, boil, then boil 10 minutes with slow fire, use filtered through gauze;
Step 3): by step 1) and step 2) medicine juice of gained 1:1 mixing by volume, the extracting juice total amount is 200～300mL approximately.
Obtain the herbal mixture compositions decoction of this treatment chronic lymphocytic thyroiditis.
Pharmacology analysis
Radix Astragali: sweet in the mouth, slightly warm in nature; Return lung, spleen, liver, kidney channel; Benefiting QI for strengthening the superficies, arresting sweating take off, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.
Radix Codonopsis: sweet in the mouth, property is flat; Return spleen, lung meridian; Invigorating the spleen and replenishing QI, promote the production of body fluid and nourish blood.
Radix Angelicae Sinensis: sweet in the mouth, suffering, hardship, warm in nature; Return liver, the heart, spleen channel; Enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature; Return liver, gallbladder, pericardium channel; Blood and dissolving stasis; Activating QI to alleviate the depression; Wind-expelling pain-stopping.
Spica Prunellae: sweet in the mouth, suffering, micro-hardship, cold in nature; Have and let out clearly liver-fire, mass dissipating and swelling eliminating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, cooling blood for hemostasis.
Radix Bupleuri: bitter in the mouth, suffering, cold nature; Return Liver Channel, gallbladder meridian; Tool depressed liver-energy dispersing and function of gallbladder promoting, thin gas resolving depression, loose effect of fire.
Poria: sweet in the mouth, light, property is flat; GUIXIN warp, lung meridian, spleen channel, kidney channel; The diuretic medicine; Diuretics with the action of eliminating dampness.
Herba Epimedii: acrid in the mouth, sweet, warm in nature; Return liver, kidney channel; Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.
Exocarpium Citri Rubrum: acrid in the mouth, hardship, warm in nature; Return lung, spleen channel; Cold expelling, dampness, promoting the circulation of QI, expectorant.
Fructus Aurantii: bitter in the mouth, acid, cold nature; Return lung, spleen, liver, stomach, large intestine channel; Dispelling the stagnated QI, row expectorant, removing food stagnancy, chest and diaphragm feeling of fullness; Distending pain over the hypochondrium; Accumulation of food in the stomach and intes tine due to indigestion; Distension and fullness in the abdomen.
Pericarpium Citri Reticulatae: bitter in the mouth, suffering, warm in nature; Return lung, spleen channel; Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Radix Glycyrrhizae Preparata: sweet in the mouth, property is flat; GUIXIN, lung, spleen, stomach warp; The spleen reinforcing stomach function regulating, Yiqi and vein recovery, for weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.
Belong to the category of the toxic goiter of goiter in the thyroiditis theory of Chinese medical science.Therefore, the dispersing swelling and dissipating binds class Chinese medicines such as Spica Prunellae commonly used, Fructus Arctii, curative effect is better.Spica Prunellae is rich in Phenylpropanoid Glycosides and tricyclene class, flavone, phenolic acid, polysaccharide etc., the variation of anti-curing oncoma mechanism, relating to antimutagenic, suppress cell proliferation, cell death inducing, inhibition angiogenesis, cytotoxicity, anti-invasion transfer, antioxidation, reversing tumor drug resistance, immunomodulating etc., is the representative of Chinese medicine multicomponent, multiple target effect.56 routine HT patients are divided into to treatment group (30 example) and matched group (26 example) at random.Result shows, after being aided with the Spica Prunellae oral liquid treatment, thyroid function is recovered obviously faster than matched group, the sustainable HT toxication of effectively controlling, the generation of inhibition hypothyroidism.Most HT patient clinicals occur that stagnation of QI expectorant coagulates or deficiency of both QI and YIN, and with emotion irritability, irritability, To Be Protected from Heat, easily antiperspirant, bitter taste, cardiopalmus, insomnia, dreaminess, become thin, the symptom such as red tongue with thin fur, belong to the disease of deficiency in origin and excess in superficiality in theory of Chinese medical science, therefore, the Chinese medicine of application invigorating spleen to remove dampness is to improve this type of symptom.Radix Codonopsis, Radix Astragali invigorating the spleen and replenishing QI, invigorating spleen to remove dampness, eliminate the phlegm; Poria, Pericarpium Citri Reticulatae circulation of qi promoting spleen invigorating, removing dampness; But Herba Epimedii and Fructus Alpiniae Oxyphyllae the kidney warming Gu Yuan.Invigorating spleen to remove dampness, nifedipine gas class Chinese medicine supplement from patient's kidney source, marrow, and effect is better.In traditional Chinese medical science research, the morbidity cause of HT is relevant with plain body deficiency, feelings will internal injury, six evil, drinking and eating irregularly etc., and the symptoms such as qi-blood disharmony, qi depression to blood stasis, deficiency and coldness are often arranged.Warming YANG to expel cold class Chinese medicine can activate yang loose stagnant, and negative and positive are all mended.The Herba Epimedii warming YANG to expel cold.
The present invention is a kind of treats that the herbal mixture compositions of chronic lymphocytic thyroiditis is cheap, determined curative effect, mutually supplement and coordinate by active ingredient and the reasonable compatibility of assisting a ruler in governing a country each component of composition, effect, there is short treating period, instant effect, the advantages such as good effect, and be pure natural crude drug compatibility, can not have side effects, dependency and Drug resistance, be widely used in prevention, control and the treatment of chronic lymphocytic thyroiditis.
The specific embodiment
Embodiment 1:
1, get Radix Astragali 30g, Radix Codonopsis 15g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 10g, Spica Prunellae 15g, Radix Bupleuri 12g, Poria 12g, Herba Epimedii 10g, Exocarpium Citri Rubrum 10g, Fructus Aurantii 10g, Pericarpium Citri Reticulatae 9g, Radix Glycyrrhizae Preparata 6g, mix;
2, the mixing Chinese medicine that 500mL water is added to step 1 gained, first boil with intense fire, then boil 15 minutes with slow fire, uses filtered through gauze;
3,250mL water is added in the medicinal residues of step 2 gained, first with intense fire, boil, then boil 10 minutes with slow fire, use filtered through gauze;
4, by the 1:1 mixing by volume of the medicine juice of 2 and 3 gained, the extracting juice total amount is 200～300mL approximately.
Obtain the herbal mixture compositions decoction A of this treatment chronic lymphocytic thyroiditis.
Embodiment 2:
1, get living Radix Astragali 32g, Radix Codonopsis 13g, Radix Angelicae Sinensis 17g, Rhizoma Chuanxiong 8g, Spica Prunellae 17g, Radix Bupleuri 10g, Poria 14g, Herba Epimedii 8g, Exocarpium Citri Rubrum 12g, Fructus Aurantii 8g, Pericarpium Citri Reticulatae 11g, Radix Glycyrrhizae Preparata 4g, mix;
2,500mL water is added in the mixing Chinese medicine of step 1 gained, first with intense fire, boil, then boil 15 minutes with slow fire, use filtered through gauze;
3,250mL water is added in the medicinal residues of step 2 gained, first with intense fire, boil, then boil 10 minutes with slow fire, use filtered through gauze;
4, by the 1:1 mixing by volume of the medicine juice of step 2 and step 3 gained, the extracting juice total amount is 200～300mL approximately.
Obtain the herbal mixture compositions decoction B of this treatment chronic lymphocytic thyroiditis.
Embodiment 3:
1, get Radix Astragali 28g, Radix Codonopsis 17g, Radix Angelicae Sinensis 13g, Rhizoma Chuanxiong 12g, Spica Prunellae 13g, Radix Bupleuri 14g, Poria 10g, Herba Epimedii 12g, Exocarpium Citri Rubrum 8g, Fructus Aurantii 12g, Pericarpium Citri Reticulatae 7g, Radix Glycyrrhizae Preparata 8g, mix;
2, the mixing Chinese medicine that 500mL water is added to step 1 gained, first boil with intense fire, then boil 15 minutes with slow fire, uses filtered through gauze;
3,250mL water is added in the medicinal residues of step 2 gained, first with intense fire, boil, then boil 10 minutes with slow fire, use filtered through gauze;
4, by the 1:1 mixing by volume of the medicine juice of 2 and 3 gained, the extracting juice total amount is 200～300mL approximately.
Obtain the herbal mixture compositions decoction C of this treatment chronic lymphocytic thyroiditis.
Embodiment 4:
1, get Radix Astragali 40g, Radix Codonopsis 25g, Radix Angelicae Sinensis 25g, Rhizoma Chuanxiong 3g, Spica Prunellae 25g, Radix Bupleuri 10g, Poria 30g, Herba Epimedii 5g, Exocarpium Citri Rubrum 25g, Fructus Aurantii 5g, Pericarpium Citri Reticulatae 20g, Radix Glycyrrhizae Preparata 3g, mix;
2, the mixing Chinese medicine that 500mL water is added to step 1 gained, first boil with intense fire, then boil 15 minutes with slow fire, uses filtered through gauze;
3,250mL water is added in the medicinal residues of step 2 gained, first with intense fire, boil, then boil 10 minutes with slow fire, use filtered through gauze;
4, by the 1:1 mixing by volume of the medicine juice of 2 and 3 gained, the extracting juice total amount is 200～300mL approximately.
Obtain the herbal mixture compositions decoction D of this treatment chronic lymphocytic thyroiditis.
Embodiment 5:
1, get Radix Astragali 20g, Radix Codonopsis 25g, Radix Angelicae Sinensis 5g, Rhizoma Chuanxiong 20g, Spica Prunellae 5g, Radix Bupleuri 30g, Poria 10g, Herba Epimedii 25g, Exocarpium Citri Rubrum 5g, Fructus Aurantii 25g, Pericarpium Citri Reticulatae 5g, Radix Glycyrrhizae Preparata 9g, mix;
2, the mixing Chinese medicine that 500mL water is added to step 1 gained, first boil with intense fire, then boil 15 minutes with slow fire, uses filtered through gauze;
3,250mL water is added in the medicinal residues of step 2 gained, first with intense fire, boil, then boil 10 minutes with slow fire, use filtered through gauze;
4, by the 1:1 mixing by volume of the medicine juice of 2 and 3 gained, the extracting juice total amount is 200～300mL approximately.
Obtain the herbal mixture compositions decoction E of this treatment chronic lymphocytic thyroiditis.
Above-mentioned embodiment is intended to illustrate the present invention and can be professional and technical personnel in the field's realization or use; it will be apparent for those skilled in the art that above-mentioned embodiment is modified; therefore the present invention includes but be not limited to above-mentioned embodiment; any these claims or description of meeting described; meet and principle disclosed herein and novelty, the method for inventive features, technique, product, within all falling into protection scope of the present invention.
Claims (5)
1. a herbal mixture compositions for the treatment of chronic lymphocytic thyroiditis, it is characterized in that: this herbal mixture compositions by following component according to shown in the weight ratio scope formulated, 20～40 parts of Radix Astragali, 5～25 parts of Radix Codonopsis, 5～25 parts of Radix Angelicae Sinensis, 3～20 parts of Rhizoma Chuanxiongs, 5～25 parts of Spica Prunellaes, 10～30 parts of Radix Bupleuri, 10～30 parts, Poria, 5～25 parts of Herba Epimedii, 5～25 parts of Exocarpium Citri Rubrums, 5～25 parts of Fructus Aurantiis, 5～20 parts of Pericarpium Citri Reticulataes, 3～9 parts of Radix Glycyrrhizae Preparatas.
2. the herbal mixture compositions for the treatment of chronic lymphocytic thyroiditis according to claim 1, it is characterized in that: described herbal mixture compositions by following component according to shown in the weight ratio scope formulated, 28～32 parts of Radix Astragali, 13～17 parts of Radix Codonopsis, 13～17 parts of Radix Angelicae Sinensis, 8～12 parts of Rhizoma Chuanxiongs, 13～17 parts of Spica Prunellaes, 10～14 parts of Radix Bupleuri, 10～14 parts, Poria, 8～12 parts of Herba Epimedii, 8～12 parts of Exocarpium Citri Rubrums, 8～12 parts of Fructus Aurantiis, 7～11 parts of Pericarpium Citri Reticulataes, 4～8 parts of Radix Glycyrrhizae Preparatas.
3. the herbal mixture compositions for the treatment of chronic lymphocytic thyroiditis according to claim 2, it is characterized in that: described herbal mixture compositions by following component according to shown in the weight ratio scope formulated, 30 parts of Radix Astragali, 15 parts of Radix Codonopsis, 15 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 15 parts of Spica Prunellaes, 12 parts of Radix Bupleuri, 12 parts, Poria, 10 parts of Herba Epimedii, 10 parts of Exocarpium Citri Rubrums, 10 parts of Fructus Aurantiis, 9 parts of Pericarpium Citri Reticulataes, 6 parts of Radix Glycyrrhizae Preparatas.
4. the herbal mixture compositions for the treatment of chronic lymphocytic thyroiditis according to claim 3, it is characterized in that: single pair of formula of described herbal mixture compositions is, Radix Astragali 30g, Radix Codonopsis 15g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 10g, Spica Prunellae 15g, Radix Bupleuri 12g, Poria 12g, Herba Epimedii 10g, Exocarpium Citri Rubrum 10g, Fructus Aurantii 10g, Pericarpium Citri Reticulatae 9g, Radix Glycyrrhizae Preparata 6g.
5. the herbal mixture compositions for the treatment of chronic lymphocytic thyroiditis according to claim 4, it is characterized in that: its decoction comprises the following steps,
Step 1): 500mL water is added by mixing Chinese medicine claimed in claim 4, first with intense fire, boil, then boil 15 minutes with slow fire, use filtered through gauze;
Step 2): 250mL water is added in the medicinal residues of step 1) gained, first with intense fire, boil, then boil 10 minutes with slow fire, use filtered through gauze;
Step 3): by step 1) and step 2) medicine juice of gained 1:1 mixing by volume, the extracting juice total amount is 200～300mL approximately.
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Cited By (4)
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| CN105106587A (en) * | 2015-09-18 | 2015-12-02 | 山东省立医院 | Traditional Chinese medicine for treating hashimoto thyroiditis and preparation method thereof |
| CN106214948A (en) * | 2016-08-31 | 2016-12-14 | 陕西省中医医院 | One treats medicine strumous and preparation method thereof |
| CN107126549A (en) * | 2017-05-09 | 2017-09-05 | 赵学友 | It is a kind of to treat pharmaceutical composition of Hashimoto's thyroiditis and preparation method thereof |
| CN110251549A (en) * | 2019-06-24 | 2019-09-20 | 浙江省肿瘤医院 | Application of the barren wort total chromocor extract in the drug or health care product of preparation prevention and treatment Hashimoto thyroiditis |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106587A (en) * | 2015-09-18 | 2015-12-02 | 山东省立医院 | Traditional Chinese medicine for treating hashimoto thyroiditis and preparation method thereof |
| CN105106587B (en) * | 2015-09-18 | 2018-10-16 | 山东省立医院 | A kind of Chinese medicine and preparation method thereof for treating Hashimoto's thyroiditis |
| CN106214948A (en) * | 2016-08-31 | 2016-12-14 | 陕西省中医医院 | One treats medicine strumous and preparation method thereof |
| CN107126549A (en) * | 2017-05-09 | 2017-09-05 | 赵学友 | It is a kind of to treat pharmaceutical composition of Hashimoto's thyroiditis and preparation method thereof |
| CN110251549A (en) * | 2019-06-24 | 2019-09-20 | 浙江省肿瘤医院 | Application of the barren wort total chromocor extract in the drug or health care product of preparation prevention and treatment Hashimoto thyroiditis |
| CN110251549B (en) * | 2019-06-24 | 2021-12-03 | 浙江省肿瘤医院 | Application of epimedium total flavone extract in preparing medicine for preventing and treating hashimoto thyroiditis |
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Application publication date: 20140101 |