WO2016141756A1 - Headache-relieving patch and preparation method therefor - Google Patents

Headache-relieving patch and preparation method therefor Download PDF

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WO2016141756A1
WO2016141756A1 PCT/CN2015/099074 CN2015099074W WO2016141756A1 WO 2016141756 A1 WO2016141756 A1 WO 2016141756A1 CN 2015099074 W CN2015099074 W CN 2015099074W WO 2016141756 A1 WO2016141756 A1 WO 2016141756A1
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layer
polymer gel
headache
essential oil
soothing
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PCT/CN2015/099074
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Chinese (zh)
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施敬东
施苏鄂
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施敬东
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

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  • the invention relates to a soothing headache stick and a preparation method thereof.
  • the technical problem to be solved by the present invention is to provide a soothing headache patch which is convenient to use and can effectively treat and relieve headache.
  • the technical solution adopted by the present invention is:
  • Soothing headache stick which consists of a backing layer, a polymer gel layer and a release layer, the release layer is located on the upper layer of the polymer gel layer, the backing layer is located on the lower layer of the polymer gel layer, and the polymer gel layer
  • the composition is by weight:
  • the weight ratio of each component in the above polymer gel material is: 4.8-5.2% sodium polyacrylate, 24.3-25.2% glycerin, 0.1-0.2% galaluminum, 0.3-0.5% crospovidone, 0.3- 0.5% polyvinylpyrrolidone, 0.2-0.4% tartaric acid.
  • the method for preparing the soothing headache patch comprises the steps of: mixing sodium polyacrylate, glycerin and aluminum hydroxyaluminate in a polymer gel material for 20-25 min, and then adding crospovidone, polyvinylpyrrolidone and tartaric acid thereto. And purified water, vacuum mixing and stirring for 5-8min, then add peppermint essential oil, lemon essential oil and eucalyptus essential oil, vacuum stirring for 4-6min, then apply to the release layer, and finally attached to the backing layer.
  • Peppermint essential oil has the effect of refreshing, relieving headache and relieving tension
  • Lemon essential oil has a refreshing spirit and relieves irritability
  • Eucalyptus essential oil has the effect of relieving fatigue and tightening and relaxing the skin.
  • the soothing headache sticker of the invention adopts a combination of a polymer gel material and an essential oil, and is absorbed into the human body through skin penetration, so as to instantly alleviate and relieve symptoms such as migraine and pain caused by various headaches, Good efficacy, long duration, good adhesion, no toxic side effects, easy to use and so on.
  • Soothing headache stick which consists of a backing layer, a polymer gel layer and a release layer, the release layer is located on the upper layer of the polymer gel layer, the backing layer is located on the lower layer of the polymer gel layer, and the polymer gel layer
  • the composition is by weight:
  • the weight ratio of each component in the polymer gel material is: 4.8% sodium polyacrylate, 24.3% glycerin, 0.1% galaluminum, 0.3% crospovidone, 0.3% polyvinylpyrrolidone, 0.2% tartaric acid .
  • the method for preparing the soothing headache patch comprises the steps of: mixing sodium polyacrylate, glycerin and aluminum hydroxyaluminate in a polymer gel material for 20 minutes, and then adding crospovidone, polyvinylpyrrolidone, tartaric acid and purification thereto. Water, vacuum mixing and stirring for 5 min, then add peppermint essential oil, lemon essential oil and eucalyptus essential oil, vacuum stir for 4 min, apply on the release layer, and finally paste on the backing layer.
  • Soothing headache stick which consists of a backing layer, a polymer gel layer and a release layer, the release layer is located on the upper layer of the polymer gel layer, the backing layer is located on the lower layer of the polymer gel layer, and the polymer gel layer
  • the composition is by weight:
  • the weight ratio of each component in the polymer gel material is: 4.8% sodium polyacrylate, 25% glycerin, 0.1% galaluminum, 0.4% crospovidone, 0.4% polyvinylpyrrolidone, 0.3% tartaric acid .
  • the method for preparing the soothing headache patch comprises the steps of: mixing sodium polyacrylate, glycerin and aluminum hydroxyaluminate in a polymer gel material for 23 minutes, and then adding crospovidone, polyvinylpyrrolidone, tartaric acid and purification thereto. Water, vacuum mixing and stirring for 6 min, then add peppermint essential oil, lemon essential oil and eucalyptus essential oil, vacuum stir for 5 min, apply to the release layer, and finally paste on the backing layer.
  • Soothing headache stick which consists of a backing layer, a polymer gel layer and a release layer, the release layer is located on the upper layer of the polymer gel layer, the backing layer is located on the lower layer of the polymer gel layer, and the polymer gel layer
  • the composition is by weight:
  • the weight ratio of each component in the polymer gel material is: 5.2% sodium polyacrylate, 25.2% glycerin, 0.2% galaluminum, 0.5% crospovidone, 0.5% polyvinylpyrrolidone, 0.4% tartaric acid .
  • the method for preparing the soothing headache patch comprises the steps of: mixing sodium polyacrylate, glycerin and aluminum hydroxyaluminate in a polymer gel material for 25 minutes, and then adding crospovidone, polyvinylpyrrolidone, tartaric acid and purification thereto. Water, vacuum mixing and stirring for 8 min, then add peppermint essential oil, lemon essential oil and eucalyptus essential oil, vacuum stir for 6 min, apply on the release layer, and finally paste on the backing layer.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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Abstract

A headache-relieving patch, consisting of a back lining layer, a polymer gel layer and an anti-sticking layer. The anti-sticking layer is located at an upper layer of the polymer gel layer. The back lining layer is located at a lower layer of the polymer gel layer. The polymer gel layer consists of a polymer gel material, medical ethyl alcohol with the concentration of 75 percent, mint essential oil, lemon essential oil, eucalyptus leaf essential oil and pure water. The patch is absorbed into a human body by virtue of skin permeation, can alleviate and relieve pains caused by migraine and various headaches in time, and has the characteristics of good treatment effect, long duration, good adhesive force, no toxic/side effect and convenience in use.

Description

舒缓头痛贴及其制作方法Soothing headache stick and its making method 技术领域Technical field
本发明涉及一种舒缓头痛贴及其制作方法。The invention relates to a soothing headache stick and a preparation method thereof.
背景技术Background technique
随着人们工作和生活压力的逐渐增大，很容易出现紧张性头痛、浮躁、易疲惫等状况。为了缓解这些状况，人们通常会选择运动、芳香疗等方法，但运动需要占用不少的时间，对于突发性的头痛不能达到有效的治疗，而芳香疗法大多是将精油直接涂抹在皮肤上，并稍加按摩，但这种方法需要用手去触碰，不方便，且极易挥发，效果持续时间较短。As people's work and life pressures gradually increase, it is prone to tension headaches, impetuousness, and fatigue. In order to alleviate these conditions, people usually choose sports, aromatherapy, etc., but exercise takes a lot of time, and can not achieve effective treatment for sudden headaches, and aromatherapy mostly applies essential oil directly to the skin. And a little massage, but this method needs to be touched by hand, inconvenient, and very volatile, the effect lasts for a short time.
发明内容Summary of the invention
本发明所要解决的技术问题是提供一种使用方便，且能有效治疗和缓解头痛的舒缓头痛贴。The technical problem to be solved by the present invention is to provide a soothing headache patch which is convenient to use and can effectively treat and relieve headache.
为解决上述技术问题，本发明采用的技术方案是：In order to solve the above technical problems, the technical solution adopted by the present invention is:
舒缓头痛贴，其由背衬层、高分子凝胶层和防粘层组成，防粘层位于高分子凝胶层的上层，背衬层位于高分子凝胶层的下层，高分子凝胶层的组成按重量百分比为：Soothing headache stick, which consists of a backing layer, a polymer gel layer and a release layer, the release layer is located on the upper layer of the polymer gel layer, the backing layer is located on the lower layer of the polymer gel layer, and the polymer gel layer The composition is by weight:
Figure PCTCN2015099074-appb-000001
Figure PCTCN2015099074-appb-000001
Figure PCTCN2015099074-appb-000002
Figure PCTCN2015099074-appb-000002
上述高分子凝胶材料中各组分的重量配比为：4.8-5.2％聚丙烯酸钠、24.3-25.2％甘油、0.1-0.2％甘羟铝、0.3-0.5％交联聚维酮、0.3-0.5％聚乙烯吡咯烷酮、0.2-0.4％酒石酸。The weight ratio of each component in the above polymer gel material is: 4.8-5.2% sodium polyacrylate, 24.3-25.2% glycerin, 0.1-0.2% galaluminum, 0.3-0.5% crospovidone, 0.3- 0.5% polyvinylpyrrolidone, 0.2-0.4% tartaric acid.
上述舒缓头痛贴的制作方法，包括以下步骤：将高分子凝胶材料中的聚丙烯酸钠、甘油和甘羟铝混合搅拌20-25min，再向其中加入交联聚维酮、聚乙烯吡咯烷酮、酒石酸以及纯化水，真空混合搅拌5-8min，然后加入薄荷精油、柠檬精油和桉叶精油，真空搅拌4-6min后涂布于防粘层上，最后贴与背衬层上即可。The method for preparing the soothing headache patch comprises the steps of: mixing sodium polyacrylate, glycerin and aluminum hydroxyaluminate in a polymer gel material for 20-25 min, and then adding crospovidone, polyvinylpyrrolidone and tartaric acid thereto. And purified water, vacuum mixing and stirring for 5-8min, then add peppermint essential oil, lemon essential oil and eucalyptus essential oil, vacuum stirring for 4-6min, then apply to the release layer, and finally attached to the backing layer.
功效：efficacy:
薄荷精油具有提神醒脑，减轻头痛，舒缓紧张情绪的功效；Peppermint essential oil has the effect of refreshing, relieving headache and relieving tension;
柠檬精油具有提神精神，缓解烦躁的功效；Lemon essential oil has a refreshing spirit and relieves irritability;
桉叶精油具有缓解疲劳，紧缩松弛肌肤的功效。Eucalyptus essential oil has the effect of relieving fatigue and tightening and relaxing the skin.
本发明的优点是：本发明的舒缓头痛贴采用高分子凝胶材料与精油结合的方式，通过皮肤渗透吸收进入人体，可即时减轻并舒缓偏头痛及各类头痛引起的痛楚等不适症状，具有功效好、持续时间长、粘着力好、无毒副作用、使用方便等特点。The invention has the advantages that: the soothing headache sticker of the invention adopts a combination of a polymer gel material and an essential oil, and is absorbed into the human body through skin penetration, so as to instantly alleviate and relieve symptoms such as migraine and pain caused by various headaches, Good efficacy, long duration, good adhesion, no toxic side effects, easy to use and so on.
具体实施方式：detailed description:
下面结合实施例对本发明作进一步详细描述。以下实施例用于说明本发明，但不用来限制本发明的范围。The present invention will be further described in detail below with reference to the embodiments. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
实施例1 Example 1
舒缓头痛贴，其由背衬层、高分子凝胶层和防粘层组成，防粘层位于高分子凝胶层的上层，背衬层位于高分子凝胶层的下层，高分子凝胶层的组成按重量百分比为：Soothing headache stick, which consists of a backing layer, a polymer gel layer and a release layer, the release layer is located on the upper layer of the polymer gel layer, the backing layer is located on the lower layer of the polymer gel layer, and the polymer gel layer The composition is by weight:
Figure PCTCN2015099074-appb-000003
Figure PCTCN2015099074-appb-000003
其中，高分子凝胶材料中各组分的重量配比为：4.8％聚丙烯酸钠、24.3％甘油、0.1％甘羟铝、0.3％交联聚维酮、0.3％聚乙烯吡咯烷酮、0.2％酒石酸。Wherein, the weight ratio of each component in the polymer gel material is: 4.8% sodium polyacrylate, 24.3% glycerin, 0.1% galaluminum, 0.3% crospovidone, 0.3% polyvinylpyrrolidone, 0.2% tartaric acid .
上述舒缓头痛贴的制作方法，包括以下步骤：将高分子凝胶材料中的聚丙烯酸钠、甘油和甘羟铝混合搅拌20min，再向其中加入交联聚维酮、聚乙烯吡咯烷酮、酒石酸以及纯化水，真空混合搅拌5min，然后加入薄荷精油、柠檬精油和桉叶精油，真空搅拌4min后涂布于防粘层上，最后贴与背衬层上即可。The method for preparing the soothing headache patch comprises the steps of: mixing sodium polyacrylate, glycerin and aluminum hydroxyaluminate in a polymer gel material for 20 minutes, and then adding crospovidone, polyvinylpyrrolidone, tartaric acid and purification thereto. Water, vacuum mixing and stirring for 5 min, then add peppermint essential oil, lemon essential oil and eucalyptus essential oil, vacuum stir for 4 min, apply on the release layer, and finally paste on the backing layer.
实施例2Example 2
舒缓头痛贴，其由背衬层、高分子凝胶层和防粘层组成，防粘层位于高分子凝胶层的上层，背衬层位于高分子凝胶层的下层，高分子凝胶层的组成按重量百分比为：Soothing headache stick, which consists of a backing layer, a polymer gel layer and a release layer, the release layer is located on the upper layer of the polymer gel layer, the backing layer is located on the lower layer of the polymer gel layer, and the polymer gel layer The composition is by weight:
Figure PCTCN2015099074-appb-000004
Figure PCTCN2015099074-appb-000004
Figure PCTCN2015099074-appb-000005
Figure PCTCN2015099074-appb-000005
其中，高分子凝胶材料中各组分的重量配比为：4.8％聚丙烯酸钠、25％甘油、0.1％甘羟铝、0.4％交联聚维酮、0.4％聚乙烯吡咯烷酮、0.3％酒石酸。Wherein, the weight ratio of each component in the polymer gel material is: 4.8% sodium polyacrylate, 25% glycerin, 0.1% galaluminum, 0.4% crospovidone, 0.4% polyvinylpyrrolidone, 0.3% tartaric acid .
上述舒缓头痛贴的制作方法，包括以下步骤：将高分子凝胶材料中的聚丙烯酸钠、甘油和甘羟铝混合搅拌23min，再向其中加入交联聚维酮、聚乙烯吡咯烷酮、酒石酸以及纯化水，真空混合搅拌6min，然后加入薄荷精油、柠檬精油和桉叶精油，真空搅拌5min后涂布于防粘层上，最后贴与背衬层上即可。The method for preparing the soothing headache patch comprises the steps of: mixing sodium polyacrylate, glycerin and aluminum hydroxyaluminate in a polymer gel material for 23 minutes, and then adding crospovidone, polyvinylpyrrolidone, tartaric acid and purification thereto. Water, vacuum mixing and stirring for 6 min, then add peppermint essential oil, lemon essential oil and eucalyptus essential oil, vacuum stir for 5 min, apply to the release layer, and finally paste on the backing layer.
实施例3Example 3
舒缓头痛贴，其由背衬层、高分子凝胶层和防粘层组成，防粘层位于高分子凝胶层的上层，背衬层位于高分子凝胶层的下层，高分子凝胶层的组成按重量百分比为：Soothing headache stick, which consists of a backing layer, a polymer gel layer and a release layer, the release layer is located on the upper layer of the polymer gel layer, the backing layer is located on the lower layer of the polymer gel layer, and the polymer gel layer The composition is by weight:
Figure PCTCN2015099074-appb-000006
Figure PCTCN2015099074-appb-000006
Figure PCTCN2015099074-appb-000007
Figure PCTCN2015099074-appb-000007
其中，高分子凝胶材料中各组分的重量配比为：5.2％聚丙烯酸钠、25.2％甘油、0.2％甘羟铝、0.5％交联聚维酮、0.5％聚乙烯吡咯烷酮、0.4％酒石酸。Among them, the weight ratio of each component in the polymer gel material is: 5.2% sodium polyacrylate, 25.2% glycerin, 0.2% galaluminum, 0.5% crospovidone, 0.5% polyvinylpyrrolidone, 0.4% tartaric acid .
上述舒缓头痛贴的制作方法，包括以下步骤：将高分子凝胶材料中的聚丙烯酸钠、甘油和甘羟铝混合搅拌25min，再向其中加入交联聚维酮、聚乙烯吡咯烷酮、酒石酸以及纯化水，真空混合搅拌8min，然后加入薄荷精油、柠檬精油和桉叶精油，真空搅拌6min后涂布于防粘层上，最后贴与背衬层上即可。 The method for preparing the soothing headache patch comprises the steps of: mixing sodium polyacrylate, glycerin and aluminum hydroxyaluminate in a polymer gel material for 25 minutes, and then adding crospovidone, polyvinylpyrrolidone, tartaric acid and purification thereto. Water, vacuum mixing and stirring for 8 min, then add peppermint essential oil, lemon essential oil and eucalyptus essential oil, vacuum stir for 6 min, apply on the release layer, and finally paste on the backing layer.

Claims (3)

  1. 舒缓头痛贴，其特征在于：该舒缓头痛贴由背衬层、高分子凝胶层和防粘层组成，所述防粘层位于高分子凝胶层的上层，所述背衬层位于高分子凝胶层的下层，所述高分子凝胶层的组成按重量百分比为：a soothing headache patch, characterized in that the soothing headache patch is composed of a backing layer, a polymer gel layer and a release layer, the release layer is located on the upper layer of the polymer gel layer, and the backing layer is located in the polymer layer The lower layer of the gel layer, the composition of the polymer gel layer is by weight:
    Figure PCTCN2015099074-appb-100001
    Figure PCTCN2015099074-appb-100001
  2. 根据权利要求1所述的舒缓头痛贴，其特征在于：所述高分子凝胶材料中各组分的重量配比为：4.8-5.2％聚丙烯酸钠、24.3-25.2％甘油、0.1-0.2％甘羟铝、0.3-0.5％交联聚维酮、0.3-0.5％聚乙烯吡咯烷酮、0.2-0.4％酒石酸。The soothing headache patch according to claim 1, wherein the weight ratio of each component in the polymer gel material is: 4.8-5.2% sodium polyacrylate, 24.3-25.2% glycerin, 0.1-0.2%. Aluminum sulphate, 0.3-0.5% crospovidone, 0.3-0.5% polyvinylpyrrolidone, 0.2-0.4% tartaric acid.
  3. 根据权利要求1或2所述的舒缓头痛贴的制作方法，其特征在于：包括以下步骤：将高分子凝胶材料中的聚丙烯酸钠、甘油和甘羟铝混合搅拌20-25min，再向其中加入交联聚维酮、聚乙烯吡咯烷酮、酒石酸以及纯化水，真空混合搅拌5-8min，然后加入薄荷精油、柠檬精油和桉叶精油，真空搅拌4-6min后涂布于防粘层上，最后贴与背衬层上即可。 The method for preparing a soothing headache patch according to claim 1 or 2, comprising the steps of: mixing sodium polyacrylate, glycerin and aluminum hydroxyaluminate in the polymer gel material for 20-25 min, and then adding thereto Add crospovidone, polyvinylpyrrolidone, tartaric acid and purified water, mix and mix under vacuum for 5-8min, then add peppermint essential oil, lemon essential oil and eucalyptus essential oil, vacuum stir for 4-6min, then apply on the anti-adhesion layer, finally Stick to the backing layer.
PCT/CN2015/099074 2015-03-12 2015-12-25 Headache-relieving patch and preparation method therefor WO2016141756A1 (en)

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