CN103239428A - Contraceptive patch and preparation method thereof - Google Patents
Contraceptive patch and preparation method thereof Download PDFInfo
- Publication number
- CN103239428A CN103239428A CN201310199070XA CN201310199070A CN103239428A CN 103239428 A CN103239428 A CN 103239428A CN 201310199070X A CN201310199070X A CN 201310199070XA CN 201310199070 A CN201310199070 A CN 201310199070A CN 103239428 A CN103239428 A CN 103239428A
- Authority
- CN
- China
- Prior art keywords
- agent
- cross
- contraceptive
- linking
- contraceptive stick
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002254 contraceptive effect Effects 0.000 title claims abstract description 76
- 239000003433 contraceptive agent Substances 0.000 title claims abstract description 73
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 52
- 239000000463 material Substances 0.000 claims abstract description 50
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229920000642 polymer Polymers 0.000 claims abstract description 13
- 239000004698 Polyethylene Substances 0.000 claims abstract description 11
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 11
- -1 polyethylene Polymers 0.000 claims abstract description 11
- 229920000573 polyethylene Polymers 0.000 claims abstract description 11
- 239000008213 purified water Substances 0.000 claims abstract description 11
- 238000004132 cross linking Methods 0.000 claims abstract description 8
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 65
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 30
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 26
- 230000002421 anti-septic effect Effects 0.000 claims description 25
- 239000011230 binding agent Substances 0.000 claims description 25
- 239000002270 dispersing agent Substances 0.000 claims description 25
- 239000003995 emulsifying agent Substances 0.000 claims description 25
- 230000000149 penetrating effect Effects 0.000 claims description 25
- 239000002562 thickening agent Substances 0.000 claims description 25
- 239000000080 wetting agent Substances 0.000 claims description 25
- 230000001464 adherent effect Effects 0.000 claims description 16
- 239000000126 substance Substances 0.000 claims description 15
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical group CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 10
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 10
- ILXDAXZQNSOSAE-UHFFFAOYSA-N [AlH3].[Cl] Chemical compound [AlH3].[Cl] ILXDAXZQNSOSAE-UHFFFAOYSA-N 0.000 claims description 10
- BWZOPYPOZJBVLQ-UHFFFAOYSA-K aluminium glycinate Chemical group O[Al+]O.NCC([O-])=O BWZOPYPOZJBVLQ-UHFFFAOYSA-K 0.000 claims description 10
- 229940015826 dihydroxyaluminum aminoacetate Drugs 0.000 claims description 10
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 10
- 229950008882 polysorbate Drugs 0.000 claims description 10
- 229920000136 polysorbate Polymers 0.000 claims description 10
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 10
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 10
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical group [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 10
- 239000011975 tartaric acid Substances 0.000 claims description 10
- 235000002906 tartaric acid Nutrition 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 230000001850 reproductive effect Effects 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 238000013268 sustained release Methods 0.000 abstract 2
- 239000012730 sustained-release form Substances 0.000 abstract 2
- 241000234314 Zingiber Species 0.000 abstract 1
- 235000006886 Zingiber officinale Nutrition 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 235000008397 ginger Nutrition 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 239000003961 penetration enhancing agent Substances 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 239000000341 volatile oil Substances 0.000 abstract 1
- 210000004706 scrotum Anatomy 0.000 description 9
- 230000006378 damage Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 210000004392 genitalia Anatomy 0.000 description 4
- 208000007536 Thrombosis Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 210000000582 semen Anatomy 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000000920 spermatogeneic effect Effects 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 210000001215 vagina Anatomy 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 208000008899 Habitual abortion Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 201000008100 Vaginitis Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000011449 brick Substances 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 230000008175 fetal development Effects 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 208000007106 menorrhagia Diseases 0.000 description 1
- 239000003539 oral contraceptive agent Substances 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 210000003101 oviduct Anatomy 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000019100 sperm motility Effects 0.000 description 1
- 230000021595 spermatogenesis Effects 0.000 description 1
- GOLXNESZZPUPJE-UHFFFAOYSA-N spiromesifen Chemical compound CC1=CC(C)=CC(C)=C1C(C(O1)=O)=C(OC(=O)CC(C)(C)C)C11CCCC1 GOLXNESZZPUPJE-UHFFFAOYSA-N 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Images
Landscapes
- Medicinal Preparation (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a contraceptive patch, comprising a contraceptive patch body, wherein the contraceptive patch body is composed of a backing layer, a gel layer and an anti-sticking layer; and external expansion slots in accordance with the physiological curve are formed at the four edges of the contraceptive patch body. The invention also discloses a preparation method of the contraceptive patch. The preparation method comprises the following steps of: adding a preservative, a penetration enhancer and a regulator to a polymer gel material; performing cross-linking polymerization on the mixed materials; adding a primary cross-linking agent and a re-cross-linking agent in the cross-linking polymerization process; furthermore, adding ginger essential oil, medical ethanol and the balance of purified water in the cross-linking polymerization process; and finally, evenly dispersing and mixing the materials into a novel polymer sustained-release material containing active ingredients; coating a polyethylene film with the novel polymer sustained-release material to form an attached preparation, and then sticking the attached preparation to non-woven fabrics, thus obtaining the contraceptive patch. Once the contraceptive patch is stuck to the reproductive organ of the male, the active ingredients in the gel layer are capable of increasing the temperature to kill sperms, thus achieving the contraceptive effect; and the contraceptive patch is harmless for the body.
Description
Technical field
The present invention relates to a kind of contraceptive stick.
The invention still further relates to a kind of preparation method of contraceptive stick.
Background technology
In today that attitude towards sex is opened day by day, contraception has become the part of people's daily life.Because the uncomfortable use contraceptive device of some Mr. and Mrs, again long-term oral contraceptive is felt scruple, just become afterwards the person who has rendered outstanding service that remedies so buy convenient, effective emergency contraception, even some women takes emergency contraception for a long time and practises contraception.Emergency contraception is not that chewing gum is not just helped yourself, frequently take emergency contraception, can cause very big harm to health, frequently take harm the more, repeated multiple times is taken emergency contraception in a short time, can cause symptoms such as serious endocrine regulation, menoxenia, menostaxis.In addition, frequently take emergency contraception and can reduce secretions in the vagina, not only reduce the resistance to alien bacteria, easily cause vaginitis, gynecopathy such as pelvic inflammatory disease, also reduce the lubrication of vagina simultaneously, influence the quality of sexual life; Also may cause irremediable functional injury to genitals such as fallopian tube, ovaries in addition, cause habitual abortion, fetal development is undesired etc., has a strong impact on fertility.
Commercially available contraceptive stick enters body by the form of patch with the medicine transdermal flux, produces contraceptive efficacy, generally is bonded at four positions of human body: buttocks, abdominal part, the arm outside and the shoulder outside, forbid being attached to chest.The transdermal penetration medicine is gone in the body, suppresses the ovum discharging, and maid's proliferative cervical mucus thickening, causes sperm uterus more difficult to get access, causes contraceptive effect to reach.But this contraceptive stick life-time service, the result of study up-to-date according to FDA shows, contraceptive stick can increase the blood clot risk, and the thrombosis that forms because shank enters pulmonary, brain and heart and fatal, and that contraceptive stick causes the probability ratio of thrombosis to be taken medicine is high 3 times.
Sperm quality is the important indicator of reaction male reproductive function, sperm must be under 34-35 ℃ constant temperature could normal development, therefore any factor that the scrotum temperature is raise all may influence the function of spermatogenic cell, causes dyszoospermia, thereby influences semen quality.There are some researches show, often wash steam bath, sleep winter electric blanket or hot a heatable brick bed may make the temperature of scrotum part raise, thereby influence the spermatogenesis process, cause semen quality to descend.
Propulsion has considerable influence to the water temperature of having a bath to sperm, often with the hot water temperature person of having a bath (26 people) with moderate water temperature (442 people), compare than the cold water temperature person of having a bath (29 people), sperm propulsion rate is lower, be respectively 47.07%, 59.89%, 65.58%, through the Wilcoxon check extremely significantly meaning (P＜0.01) arranged.The hotter propulsion that has a strong impact on sperm of the water temperature of having a bath, readme is 47.07% with the male's that has a bath than the hot water temperature sperm propulsion rate often, be lower than WHO specified standard (〉=50%), compared remarkable difference with the water temperature of having a bath moderate (59.89%), the cooler person of water temperature (65.58%), so temperature has significant effects to the genital orgnas,male.
Therefore, be badly in need of a kind of improved technology and solve existing this problem in the prior art.
Summary of the invention
The purpose of this invention is to provide the contraceptive stick that a kind of contraceptive effect is good, do not have harm.
Another object of the present invention provides a kind of preparation method of contraceptive stick.
The technical solution used in the present invention is:
Contraceptive stick, comprise the contraceptive stick body, described contraceptive stick body is made up of backing layer, gel layer and adherent layer, and described adherent layer is positioned at the upper strata of gel layer, described backing layer is positioned at the lower floor of gel layer, and described contraceptive stick body four limits have the seam that extends out that meets physiological curve.
Described backing layer is made of non-woven fabrics.
Described adherent layer is made up of polyethylene film.
Described gel layer is the high-molecular gel layer.
The composition of described high-molecular gel layer is by weight percentage:
High-molecular gel material 30-32%;
Rhizoma Zingiberis Recens quintessence oil 1-2%;
Mass concentration is 75% medical ethanol 1-2%;
Chemical addition agent 1.4-1.5%;
Purified water complements to 100%.
Described high-molecular gel material comprises wetting agent, dispersant, emulsifying agent, thickening agent and binder, described wetting agent is glycerol, and described dispersant is sodium polyacrylate, and emulsifying agent is polysorbate, described binder is polyvinylpyrrolidone, and described thickening agent is tartaric acid.
Described chemical addition agent comprises antiseptic, penetrating agent, pH regulator agent, first cross-linking agent and multiple cross-linking agent, described antiseptic is germall BP, and described penetrating agent is azone, and described pH regulator agent is citric acid, described cross-linking agent just is six water chlorine aluminum, and described multiple cross-linking agent is dihydroxyaluminum aminoacetate.
A kind of preparation method of contraceptive stick, may further comprise the steps: with the wetting agent in the high-molecular gel material, dispersant, emulsifying agent, thickening agent and binder, according to mass percent 27-29%:2%:0.2%:0.3%:0.5% mix homogeneously, add the quality percentage composition again in the high-molecular gel material and be 0.12% antiseptic, the penetrating agent of 0.5-0.6%, 0.6% pH regulator agent, the material of above-mentioned mixing is carried out cross-linked polymeric, 50-70 ℃ of control temperature, adding quality percentage composition is 0.1% first cross-linking agent and 0.08% multiple cross-linking agent in the cross-linked polymeric process, adding the quality percentage composition in the cross-linking polymerization process again is the Rhizoma Zingiberis Recens quintessence oil of 1-2%, the mass concentration of 1-2% is 75% medical ethanol and the purified water of adding surplus, at stirrer for mixing 8-10 minute, last above-mentioned material evenly disperses to be mixed into the novel high polymer slow-release material that contains active component, the novel high polymer slow-release material is coated on the polyethylene film, make attached preparation, again attached preparation is affixed on the non-woven fabrics, contraceptive stick.
Described high-molecular gel material comprises wetting agent, dispersant, emulsifying agent, thickening agent and binder, described wetting agent is glycerol, and described dispersant is sodium polyacrylate, and emulsifying agent is polysorbate, described binder is polyvinylpyrrolidone, and described thickening agent is tartaric acid.
Described chemical addition agent comprises antiseptic, penetrating agent, pH regulator agent, first cross-linking agent and multiple cross-linking agent, described antiseptic is germall BP, and described penetrating agent is azone, and described pH regulator agent is citric acid, described cross-linking agent just is six water chlorine aluminum, and described multiple cross-linking agent is dihydroxyaluminum aminoacetate.
Advantage of the present invention is: stick contraceptive stick the genital orgnas,male, the effective ingredient Rhizoma Zingiberis Recens quintessence oil in the gel layer can raise temperature, murders sperm, reaches the effect of contraception, and health is had no harm.
Description of drawings
Below in conjunction with the drawings and specific embodiments the present invention is described in further detail.
Fig. 1 is front view of the present invention.
Fig. 2 be among Fig. 1 A-A to cutaway view.
Wherein: 1, adherent layer, 2, gel layer, 3, backing layer, 4, extend out seam, 5, the contraceptive stick body.
The specific embodiment
Embodiment 1
As illustrated in fig. 1 and 2, contraceptive stick of the present invention, comprise contraceptive stick body 5, contraceptive stick body 5 is made up of backing layer 3, gel layer 2 and adherent layer 1, adherent layer 1 is positioned at the upper strata of gel layer 2, and backing layer 3 is positioned at the lower floor of gel layer 2, contraceptive stick body 5 four limits have meet physiological curve extend out the seam 4, contraceptive stick is attached on the scrotum, makes and fit more firmly.
Backing layer 3 is made of non-woven fabrics, and adherent layer 1 is made up of polyethylene film, and gel layer 2 is the high-molecular gel layer.
The composition of this high-molecular gel layer is by weight percentage:
High-molecular gel material 30%;
Rhizoma Zingiberis Recens quintessence oil 1%;
Mass concentration is 75% medical ethanol 1%;
Chemical addition agent 1.4%;
Purified water 66.6%.
Above-mentioned said high-molecular gel material comprises wetting agent, dispersant, emulsifying agent, thickening agent and binder, and wetting agent is glycerol, and dispersant is sodium polyacrylate, and emulsifying agent is polysorbate, and binder is polyvinylpyrrolidone, and thickening agent is tartaric acid.
Above-mentioned said chemical addition agent comprises antiseptic, penetrating agent, pH regulator agent, first cross-linking agent and multiple cross-linking agent, and antiseptic is germall BP, and penetrating agent is azone, and the pH regulator agent is citric acid, and first cross-linking agent is six water chlorine aluminum, and multiple cross-linking agent is dihydroxyaluminum aminoacetate.
Embodiment 2
As illustrated in fig. 1 and 2, contraceptive stick of the present invention, comprise contraceptive stick body 5, contraceptive stick body 5 is made up of backing layer 3, gel layer 2 and adherent layer 1, adherent layer 1 is positioned at the upper strata of gel layer 2, and backing layer 3 is positioned at the lower floor of gel layer 2, contraceptive stick body 5 four limits have meet physiological curve extend out the seam 4, contraceptive stick is attached on the scrotum, makes and fit more firmly.
Backing layer 3 is made of non-woven fabrics, and adherent layer 1 is made up of polyethylene film, and gel layer 2 is the high-molecular gel layer.
The composition of this high-molecular gel layer is by weight percentage:
High-molecular gel material 31%;
Rhizoma Zingiberis Recens quintessence oil 1.5%;
Mass concentration is 75% medical ethanol 1.5%;
Chemical addition agent 1.45%;
Purified water 64.55%.
Above-mentioned said high-molecular gel material comprises wetting agent, dispersant, emulsifying agent, thickening agent and binder, and wetting agent is glycerol, and dispersant is sodium polyacrylate, and emulsifying agent is polysorbate, and binder is polyvinylpyrrolidone, and thickening agent is tartaric acid.
Above-mentioned said chemical addition agent comprises antiseptic, penetrating agent, pH regulator agent, first cross-linking agent and multiple cross-linking agent, and antiseptic is germall BP, and penetrating agent is azone, and the pH regulator agent is citric acid, and first cross-linking agent is six water chlorine aluminum, and multiple cross-linking agent is dihydroxyaluminum aminoacetate.
Embodiment 3
As illustrated in fig. 1 and 2, contraceptive stick of the present invention, comprise contraceptive stick body 5, contraceptive stick body 5 is made up of backing layer 3, gel layer 2 and adherent layer 1, adherent layer 1 is positioned at the upper strata of gel layer 2, and backing layer 3 is positioned at the lower floor of gel layer 2, contraceptive stick body 5 four limits have meet physiological curve extend out the seam 4, contraceptive stick is attached on the scrotum, makes and fit more firmly.
Backing layer 3 is made of non-woven fabrics, and adherent layer 1 is made up of polyethylene film, and gel layer 2 is the high-molecular gel layer.
The composition of this high-molecular gel layer is by weight percentage:
High-molecular gel material 32%;
Rhizoma Zingiberis Recens quintessence oil 2%;
Mass concentration is 75% medical ethanol 2%;
Chemical addition agent 1.5%;
Purified water 62.5%.
Above-mentioned said high-molecular gel material comprises wetting agent, dispersant, emulsifying agent, thickening agent and binder, and wetting agent is glycerol, and dispersant is sodium polyacrylate, and emulsifying agent is polysorbate, and binder is polyvinylpyrrolidone, and thickening agent is tartaric acid.
Above-mentioned said chemical addition agent comprises antiseptic, penetrating agent, pH regulator agent, first cross-linking agent and multiple cross-linking agent, and antiseptic is germall BP, and penetrating agent is azone, and the pH regulator agent is citric acid, and first cross-linking agent is six water chlorine aluminum, and multiple cross-linking agent is dihydroxyaluminum aminoacetate.
Following examples 4-6 is the embodiment of the preparation method of contraceptive stick of the present invention.
Embodiment 4
A kind of preparation method of contraceptive stick, may further comprise the steps: with the wetting agent in the high-molecular gel material, dispersant, emulsifying agent, thickening agent and binder, according to mass percent 27%:2%:0.2%:0.3%:0.5% mix homogeneously, add the quality percentage composition again in the high-molecular gel material and be 0.12% antiseptic, 0.5% penetrating agent, 0.6% pH regulator agent, the material of above-mentioned mixing is carried out cross-linked polymeric, 50 ℃ of control temperature, adding quality percentage composition is 0.1% first cross-linking agent and 0.08% multiple cross-linking agent in the cross-linked polymeric process, add the quality percentage composition in the cross-linking polymerization process again and be 1% Rhizoma Zingiberis Recens quintessence oil, 1% mass concentration is 75% medical ethanol and 66.6% purified water, stirrer for mixing 8 minutes, last above-mentioned material evenly disperses to be mixed into the novel high polymer slow-release material that contains active component, the novel high polymer slow-release material is coated on the polyethylene film, make attached preparation, again attached preparation is affixed on the non-woven fabrics, contraceptive stick.
Above-mentioned said high-molecular gel material comprises wetting agent, dispersant, emulsifying agent, thickening agent and binder, and wetting agent is glycerol, and dispersant is sodium polyacrylate, and emulsifying agent is polysorbate, and binder is polyvinylpyrrolidone, and thickening agent is tartaric acid.
Above-mentioned said chemical addition agent comprises antiseptic, penetrating agent, pH regulator agent, first cross-linking agent and multiple cross-linking agent, and antiseptic is germall BP, and penetrating agent is azone, and the pH regulator agent is citric acid, and first cross-linking agent is six water chlorine aluminum, and multiple cross-linking agent is dihydroxyaluminum aminoacetate.
A kind of preparation method of contraceptive stick, may further comprise the steps: with the wetting agent in the high-molecular gel material, dispersant, emulsifying agent, thickening agent and binder, according to mass percent 28%:2%:0.2%:0.3%:0.5% mix homogeneously, add the quality percentage composition again in the high-molecular gel material and be 0.12% antiseptic, 0.55% penetrating agent, 0.6% pH regulator agent, the material of above-mentioned mixing is carried out cross-linked polymeric, 60 ℃ of control temperature, adding quality percentage composition is 0.1% first cross-linking agent and 0.08% multiple cross-linking agent in the cross-linked polymeric process, add the quality percentage composition in the cross-linking polymerization process again and be 1.5% Rhizoma Zingiberis Recens quintessence oil, 1.5% mass concentration is 75% medical ethanol and 64.55% purified water, stirrer for mixing 9 minutes, last above-mentioned material evenly disperses to be mixed into the novel high polymer slow-release material that contains active component, the novel high polymer slow-release material is coated on the polyethylene film, make attached preparation, again attached preparation is affixed on the non-woven fabrics, contraceptive stick.
Above-mentioned said high-molecular gel material comprises wetting agent, dispersant, emulsifying agent, thickening agent and binder, and wetting agent is glycerol, and dispersant is sodium polyacrylate, and emulsifying agent is polysorbate, and binder is polyvinylpyrrolidone, and thickening agent is tartaric acid.
Above-mentioned said chemical addition agent comprises antiseptic, penetrating agent, pH regulator agent, first cross-linking agent and multiple cross-linking agent, and antiseptic is germall BP, and penetrating agent is azone, and the pH regulator agent is citric acid, and first cross-linking agent is six water chlorine aluminum, and multiple cross-linking agent is dihydroxyaluminum aminoacetate.
Embodiment 6
A kind of preparation method of contraceptive stick, may further comprise the steps: with the wetting agent in the high-molecular gel material, dispersant, emulsifying agent, thickening agent and binder, according to mass percent 29%:2%:0.2%:0.3%:0.5% mix homogeneously, add the quality percentage composition again in the high-molecular gel material and be 0.12% antiseptic, 0.6% penetrating agent, 0.6% pH regulator agent, the material of above-mentioned mixing is carried out cross-linked polymeric, 70 ℃ of control temperature, adding quality percentage composition is 0.1% first cross-linking agent and 0.08% multiple cross-linking agent in the cross-linked polymeric process, add the quality percentage composition in the cross-linking polymerization process again and be 2% Rhizoma Zingiberis Recens quintessence oil, 2% mass concentration is 75% medical ethanol and 62.5% purified water, stirrer for mixing 10 minutes, last above-mentioned material evenly disperses to be mixed into the novel high polymer slow-release material that contains active component, the novel high polymer slow-release material is coated on the polyethylene film, make attached preparation, again attached preparation is affixed on the non-woven fabrics, contraceptive stick.
Above-mentioned said high-molecular gel material comprises wetting agent, dispersant, emulsifying agent, thickening agent and binder, and wetting agent is glycerol, and dispersant is sodium polyacrylate, and emulsifying agent is polysorbate, and binder is polyvinylpyrrolidone, and thickening agent is tartaric acid.
Above-mentioned said chemical addition agent comprises antiseptic, penetrating agent, pH regulator agent, first cross-linking agent and multiple cross-linking agent, and antiseptic is germall BP, and penetrating agent is azone, and the pH regulator agent is citric acid, and first cross-linking agent is six water chlorine aluminum, and multiple cross-linking agent is dihydroxyaluminum aminoacetate.
This composition of Rhizoma Zingiberis Recens quintessence oil has heating functioin, make temperature raise, and the optimal existence of sperm and survival temperature be than low 1 ℃-2 ℃ of normal body temperature (37.3 ℃), and the testis temperature rises to 38 ℃ with regard to regeneration sperm not, and the mature sperm temperature rises to 40 ℃, protein wherein will coagulation necrosis, boiled as a raw egg, as long as stick contraceptive stick, temperature has been raise, just can avoid using measure such as contraceptive to reach the effect of contraception, and health is had no harm.
The break traditions principle of contraceptive stick of this contraceptive stick, avoid the women to be endangered, this contraceptive stick is used for the genital orgnas,male, contraceptive stick body 5 four limits have meet physiological curve extend out the seam 4, making fits more firmly, effective ingredient Rhizoma Zingiberis Recens quintessence oil heating up in the gel layer 2 is murdered sperm, thereby reaches the effect of contraception.
Following experimental result is as can be known:
| Mode | Semen volume (ML) | Sperm concentration (10 6/ml） | Sperm sum (10 6/ml） | Sperm propulsion rate (%) | Sperm survival rate (%) | Normal morphology sperm (%) |
| Paste contraceptive stick | 2.49 | 42.90 | 98.89 | 60.46 | 74.69 | 77.24 |
| No contraceptive stick | 2.62 | 57.89 | 127.86 | 59.23 | 77.13 | 77.91 |
Studies have shown that sperm must be under 34-35 ℃ constant temperature could normal development, contraceptive stick is sticked, be that the scrotum temperature raises, can kill sperm, play the effect of contraception.Because the too high meeting of scrotum temperature has a strong impact on the function of spermatogenic cell, cause dyszoospermia, scrotum temperature by 12 weeks raises, density and the sperm sum quantity of finding sperm descend, the ratio of sperm motility and normal morphology also descends to some extent, and prompting scrotum temperature improves the effect that can play contraception.
Claims (10)
1. contraceptive stick, comprise the contraceptive stick body, it is characterized in that: described contraceptive stick body is made up of backing layer, gel layer and adherent layer, and described adherent layer is positioned at the upper strata of gel layer, described backing layer is positioned at the lower floor of gel layer, and described contraceptive stick body four limits have the seam that extends out that meets physiological curve.
2. contraceptive stick according to claim 1, it is characterized in that: described backing layer is made of non-woven fabrics.
3. contraceptive stick according to claim 1, it is characterized in that: described adherent layer is made up of polyethylene film.
4. contraceptive stick according to claim 1, it is characterized in that: described gel layer is the high-molecular gel layer.
5. contraceptive stick according to claim 4, it is characterized in that: the composition of described high-molecular gel layer is by weight percentage:
High-molecular gel material 30-32%;
Rhizoma Zingiberis Recens quintessence oil 1-2%;
Mass concentration is 75% medical ethanol 1-2%;
Chemical addition agent 1.4-1.5%;
Purified water complements to 100%.
6. contraceptive stick according to claim 5, it is characterized in that: described high-molecular gel material comprises wetting agent, dispersant, emulsifying agent, thickening agent and binder, described wetting agent is glycerol, described dispersant is sodium polyacrylate, emulsifying agent is polysorbate, described binder is polyvinylpyrrolidone, and described thickening agent is tartaric acid.
7. contraceptive stick according to claim 5, it is characterized in that: described chemical addition agent comprises antiseptic, penetrating agent, pH regulator agent, first cross-linking agent and multiple cross-linking agent, described antiseptic is germall BP, described penetrating agent is azone, described pH regulator agent is citric acid, described cross-linking agent just is six water chlorine aluminum, and described multiple cross-linking agent is dihydroxyaluminum aminoacetate.
8. the preparation method of a contraceptive stick as claimed in claim 1, it is characterized in that, may further comprise the steps: with the wetting agent in the high-molecular gel material, dispersant, emulsifying agent, thickening agent and binder, according to mass percent 27-29%:2%:0.2%:0.3%:0.5% mix homogeneously, add the quality percentage composition again in the high-molecular gel material and be 0.12% antiseptic, the penetrating agent of 0.5-0.6%, 0.6% pH regulator agent, the material of above-mentioned mixing is carried out cross-linked polymeric, 50-70 ℃ of control temperature, adding quality percentage composition is 0.1% first cross-linking agent and 0.08% multiple cross-linking agent in the cross-linked polymeric process, adding the quality percentage composition in the cross-linking polymerization process again is the Rhizoma Zingiberis Recens quintessence oil of 1-2%, the mass concentration of 1-2% is 75% medical ethanol and the purified water of adding surplus, at stirrer for mixing 8-10 minute, last above-mentioned material evenly disperses to be mixed into the novel high polymer slow-release material that contains active component, the novel high polymer slow-release material is coated on the polyethylene film, make attached preparation, again attached preparation is affixed on the non-woven fabrics, contraceptive stick.
9. the preparation method of a kind of contraceptive stick according to claim 8, it is characterized in that: described high-molecular gel material comprises wetting agent, dispersant, emulsifying agent, thickening agent and binder, described wetting agent is glycerol, described dispersant is sodium polyacrylate, emulsifying agent is polysorbate, described binder is polyvinylpyrrolidone, and described thickening agent is tartaric acid.
10. the preparation method of a kind of contraceptive stick according to claim 8, it is characterized in that: described chemical addition agent comprises antiseptic, penetrating agent, pH regulator agent, first cross-linking agent and multiple cross-linking agent, described antiseptic is germall BP, described penetrating agent is azone, described pH regulator agent is citric acid, described cross-linking agent just is six water chlorine aluminum, and described multiple cross-linking agent is dihydroxyaluminum aminoacetate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310199070.XA CN103239428B (en) | 2013-05-27 | 2013-05-27 | Contraceptive patch and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310199070.XA CN103239428B (en) | 2013-05-27 | 2013-05-27 | Contraceptive patch and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103239428A true CN103239428A (en) | 2013-08-14 |
| CN103239428B CN103239428B (en) | 2014-08-20 |
Family
ID=48919533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310199070.XA Active CN103239428B (en) | 2013-05-27 | 2013-05-27 | Contraceptive patch and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103239428B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688880A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Headache-relieving pad and preparation method thereof |
| CN104758350A (en) * | 2015-03-12 | 2015-07-08 | 施敬东 | Refreshing and cool patch and preparation method thereof |
| WO2016141754A1 (en) * | 2015-03-12 | 2016-09-15 | 施敬东 | Nerve-soothing and sleep-aiding patch and preparation method therefor |
| WO2016141757A1 (en) * | 2015-03-12 | 2016-09-15 | 施敬东 | Nerve-soothing and eye-relaxing patch and preparation method therefor |
| WO2016141755A1 (en) * | 2015-03-12 | 2016-09-15 | 施敬东 | Medical defervescence patch and preparation method therefor |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1032901A (en) * | 1988-08-28 | 1989-05-17 | 田建中 | Electrothermal contraceptive device for males |
| CN2063807U (en) * | 1988-11-18 | 1990-10-17 | 丛繁滋 | Warm type male contraceptive device |
| US5063939A (en) * | 1990-09-05 | 1991-11-12 | Walston Wayne T | Male contraceptive device |
| CN1220864A (en) * | 1997-12-26 | 1999-06-30 | 杨西永 | Male contraceptive apparatus |
| CN1227092A (en) * | 1998-02-23 | 1999-09-01 | 申洪 | Health pants for contraception |
| CN101829300A (en) * | 2010-04-13 | 2010-09-15 | 刘仁杰 | Hyperthermia agent with high thermal efficiency and multiple functions |
-
2013
- 2013-05-27 CN CN201310199070.XA patent/CN103239428B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1032901A (en) * | 1988-08-28 | 1989-05-17 | 田建中 | Electrothermal contraceptive device for males |
| CN2063807U (en) * | 1988-11-18 | 1990-10-17 | 丛繁滋 | Warm type male contraceptive device |
| US5063939A (en) * | 1990-09-05 | 1991-11-12 | Walston Wayne T | Male contraceptive device |
| CN1220864A (en) * | 1997-12-26 | 1999-06-30 | 杨西永 | Male contraceptive apparatus |
| CN1227092A (en) * | 1998-02-23 | 1999-09-01 | 申洪 | Health pants for contraception |
| CN101829300A (en) * | 2010-04-13 | 2010-09-15 | 刘仁杰 | Hyperthermia agent with high thermal efficiency and multiple functions |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688880A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Headache-relieving pad and preparation method thereof |
| CN104758350A (en) * | 2015-03-12 | 2015-07-08 | 施敬东 | Refreshing and cool patch and preparation method thereof |
| WO2016141754A1 (en) * | 2015-03-12 | 2016-09-15 | 施敬东 | Nerve-soothing and sleep-aiding patch and preparation method therefor |
| WO2016141757A1 (en) * | 2015-03-12 | 2016-09-15 | 施敬东 | Nerve-soothing and eye-relaxing patch and preparation method therefor |
| WO2016141755A1 (en) * | 2015-03-12 | 2016-09-15 | 施敬东 | Medical defervescence patch and preparation method therefor |
| WO2016141756A1 (en) * | 2015-03-12 | 2016-09-15 | 施敬东 | Headache-relieving patch and preparation method therefor |
| WO2016141758A1 (en) * | 2015-03-12 | 2016-09-15 | 施敬东 | Refreshing and cooling patch and preparation method therefor |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103239428B (en) | 2014-08-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103239428B (en) | Contraceptive patch and preparation method thereof | |
| Woolfson et al. | Drug delivery by the intravaginal route | |
| JP6124411B2 (en) | Monolithic intravaginal rings containing progesterone and methods for their production and use | |
| CN103272153B (en) | Antibacterial gel and preparation method thereof | |
| CN106466454A (en) | A kind of prevention and the gel for the treatment of gynecological inflammation | |
| CN104161895A (en) | A sperm-producing decoction | |
| WO1999038472A2 (en) | Topical vasodilatory gel composition and methods of use and production | |
| CN104173736A (en) | Kidney-tonifying sperm-growing traditional Chinese medicinal composition | |
| CN108553499A (en) | A kind of antibacterial conception control gel of the gynaecology of natural constituent and preparation method thereof | |
| CN110201049A (en) | A kind of gynaecologic antibiotic liquid of good anti-bacterial effect | |
| CN108498705A (en) | Vagina doubts glue bolt and preparation method thereof | |
| CN101007188A (en) | Drug-releasing vagina obstruction composition and preparation thereof | |
| CN203342063U (en) | Contraceptive patch | |
| Cirstoiu et al. | Adverse reactions due to use of two intrauterine devices with different action mechanism in a rare clinical case | |
| CN111012793A (en) | Antibacterial and detoxicating gynecological gel and preparation method thereof | |
| CN104873860A (en) | Self-heating gynecological inflammation medical hot compress stick and preparation method thereof | |
| CN101618192A (en) | Pharmaceutical application of pharmaceutical composition containing zedoary turmeril oil | |
| Boquet | The Negative Effects of the Pill | |
| AU2016202114B2 (en) | Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof | |
| Manasi et al. | Ayurvedic Management of Congenital Elongation of Cervix-A Single Case Study | |
| CN103445903B (en) | Condom capable of treating chronic pelvic inflammation | |
| CN104069435A (en) | Notoginseng powder | |
| CN104056019A (en) | Diuresis promoting and toxicity removing decoction | |
| Rezavand et al. | A case study of heterotype | |
| SEGALOFF | Testicular dysfunction: diagnosis and treatment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20130814 Assignee: Jiangsu sincere Pharmaceutical Co. Ltd. Assignor: Shi Jingdong Contract record no.: 2015320000274 Denomination of invention: Contraceptive patch and preparation method thereof Granted publication date: 20140820 License type: Exclusive License Record date: 20150423 |
|
| LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
| EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Jiangsu sincere Pharmaceutical Co. Ltd. Assignor: Shi Jingdong Contract record no.: 2015320000274 Date of cancellation: 20181016 |
|
| EC01 | Cancellation of recordation of patent licensing contract | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190812 Address after: 226200 Doctor Pioneer Park, 101 Nanhai Road, Binhai Industrial Park, Qidong City, Nantong City, Jiangsu Province, Building 8 Patentee after: Jiangsu sincere Pharmaceutical Co. Ltd. Address before: 226200 Room 305, Building 77, Mingzhu New Village, Huilong Town, Qidong City, Nantong City, Jiangsu Province Patentee before: Shi Jingdong |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210928 Address after: 226000 Room 305, building 77, Mingzhu new village, Huilong Town, Qidong City, Nantong City, Jiangsu Province Patentee after: Shi Jingdong Address before: 226200 Building 8, doctoral entrepreneurship Park, No. 101, Nanhai Road, Binhai Industrial Park, Qidong City, Nantong City, Jiangsu Province Patentee before: Jiangsu sincere Pharmaceutical Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20211014 Address after: 200000 floors 2, 3 and 4, No. 20, Lane 588, Tianxiong Road, Zhoupu Town, Pudong New Area, Shanghai Patentee after: SHANGHAI SINCERE PHARMACEUTICAL Co.,Ltd. Address before: 226000 Room 305, building 77, Mingzhu new village, Huilong Town, Qidong City, Nantong City, Jiangsu Province Patentee before: Shi Jingdong |
|
| TR01 | Transfer of patent right |