WO2016141757A1 - Nerve-soothing and eye-relaxing patch and preparation method therefor - Google Patents

Nerve-soothing and eye-relaxing patch and preparation method therefor Download PDF

Info

Publication number
WO2016141757A1
WO2016141757A1 PCT/CN2015/099076 CN2015099076W WO2016141757A1 WO 2016141757 A1 WO2016141757 A1 WO 2016141757A1 CN 2015099076 W CN2015099076 W CN 2015099076W WO 2016141757 A1 WO2016141757 A1 WO 2016141757A1
Authority
WO
WIPO (PCT)
Prior art keywords
layer
polymer gel
agent
adhesive
preparation
Prior art date
Application number
PCT/CN2015/099076
Other languages
French (fr)
Chinese (zh)
Inventor
施敬东
施苏鄂
Original Assignee
施敬东
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 施敬东 filed Critical 施敬东
Publication of WO2016141757A1 publication Critical patent/WO2016141757A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)

Definitions

  • the invention relates to an anti-soul eye patch, and relates to a preparation method of an anti-soul eye patch.
  • the present invention provides an anti-soul eye patch, which can both calm and sleep, and can effectively alleviate related symptoms such as eye fatigue.
  • the invention also provides a preparation method of the soothing eye patch.
  • Anshen Shu eye patch comprising Anshen Shu eye stick body, the Anshen Shu eye stick body is composed of a backing layer, a polymer gel layer and a release layer, the anti-adhesion layer is located at a high An upper layer of the molecular gel layer, the backing layer being located in a lower layer of the polymer gel layer, the polymer gel layer being composed of the following mass percentage of raw materials and a ratio thereof:
  • the pH adjusting agent is tartaric acid
  • the polymer gel material comprises a dispersing agent, a humectant, a crosslinking agent, a thickener and an adhesive
  • the dispersing agent is sorbitol
  • the humectant is glycerin.
  • the crosslinking agent is crospovidone
  • the adhesion agent is polyvinylpyrrolidone
  • the thickener is sodium polyacrylate.
  • the release layer is composed of a polyethylene film.
  • the preparation method of the above-mentioned soothing eye-protecting paste comprises the following steps: adding 18-20% humectant, 0.07-0.08% galaluminum and stirring for 20 min in a dispersing agent with a mass percentage of 0.42-0.6%; 0.08-0.1% of cross-linking agent, 4.2-5.5% thickener, 8.3-8.8% of adhesive, 0.04-0.05% of pH adjuster and the balance of purified water, and stirred under vacuum for 5-8min; Active substance: 0.1-0.5% mint, 0.5-1.5% lavender essential oil, and stirred under vacuum for 5 min, finally, the above materials are uniformly dispersed and mixed into a polymer sustained-release material containing active ingredients, and the polymer sustained-release material is coated on the release layer. On the top, the preparation is prepared, and the attached preparation is attached to the backing layer.
  • the pH adjusting agent is tartaric acid
  • the polymer gel material comprises a dispersing agent, a moisturizing agent, a crosslinking agent, a thickener and an adhesive
  • the dispersing agent is sorbitol
  • the moisturizing agent It is glycerin
  • the crosslinking agent is crospovidone
  • the adhesion agent is polyvinylpyrrolidone
  • the thickener is sodium polyacrylate.
  • the invention has the advantages that the production process is relatively convenient, the product is convenient to use, meets the needs of daily life, can not calm the eyes and sleep, and can effectively alleviate eye fatigue, eye swelling, dry eyes and other symptoms.
  • An Shen Shu eye patch including an Anshen eye patch body, the body is composed of a backing layer, a polymer gel layer and a release layer, the release layer is composed of a polyethylene film and is located on the upper layer of the polymer gel layer, the backing The layer is located in the lower layer of the polymer gel layer, and the polymer gel layer is composed of the following mass percentage of raw materials and their ratios:
  • the pH regulator is tartaric acid
  • the polymer gel material includes dispersant sorbitol, humectant glycerin, cross-linking crospovidone, thickener sodium polyacrylate and adhesive polyvinylpyrrolidone.
  • the preparation method of the above-mentioned Soothing Eye Mask comprises the following steps: adding 18% humectant glycerin, 0.07% galaluminum and stirring for 20 minutes in a dispersant sorbitol having a mass percentage of 0.42%; and adding a mass percentage of 0.08%.
  • the cross-linking agent cross-linked povidone, 4.2% thickener sodium polyacrylate, 8.3% adhesive polyvinylpyrrolidone, 0.04% pH regulator tartaric acid and the balance of purified water, and stirred under vacuum for 5-8 min;
  • the active substance is added: 0.1% mint, 0.5% lavender essential oil, and stirred under vacuum for 5 minutes.
  • the above materials are uniformly dispersed and mixed into a polymer sustained-release material containing an active ingredient, and the polymer sustained-release material is coated on the release layer. Adding the preparation, and then attaching the preparation to the backing layer paste.
  • An Shen Shu eye patch including an Anshen eye patch body, the body is composed of a backing layer, a polymer gel layer and a release layer, the release layer is composed of a polyethylene film and is located on the upper layer of the polymer gel layer, the backing The layer is located in the lower layer of the polymer gel layer, and the polymer gel layer is composed of the following mass percentage of raw materials and their ratios:
  • the pH regulator is tartaric acid
  • the polymer gel material includes dispersant sorbitol, humectant glycerin, cross-linking crospovidone, thickener sodium polyacrylate and adhesive polyvinylpyrrolidone.
  • the preparation method of the above-mentioned Soothing Eye Mask comprises the following steps: adding 20% humectant glycerin, 0.08% galaluminum and stirring for 20 minutes in a dispersant sorbitol having a mass percentage of 0.6%; and adding 0.1% by mass.
  • the cross-linking agent cross-linked povidone, 5.5% thickener sodium polyacrylate, 8.8% adhesive polyvinylpyrrolidone, 0.05% PH regulator tartaric acid and the balance of purified water, and stirred under vacuum for 5-8 min; Add active: 0.5% mint, 1.5% lavender essential oil, and stir for 5 minutes under vacuum.
  • the above materials are uniformly dispersed and mixed into a polymer sustained-release material containing active ingredients, and the polymer sustained-release material is coated on the prevention.
  • the preparation is prepared, and then the attached preparation is attached to the backing layer, that is, the nerve is refreshed.
  • An Shen Shu eye patch including an Anshen eye patch body, the body is composed of a backing layer, a polymer gel layer and a release layer, the release layer is composed of a polyethylene film and is located on the upper layer of the polymer gel layer, the backing The layer is located in the lower layer of the polymer gel layer, and the polymer gel layer is composed of the following mass percentage of raw materials and their ratios:
  • the pH regulator is tartaric acid
  • the polymer gel material includes dispersant sorbitol, humectant glycerin, cross-linking crospovidone, thickener sodium polyacrylate and adhesive polyvinylpyrrolidone.
  • the preparation method of the above-mentioned Soothing Eye Patch comprises the following steps: adding 19% of humectant glycerin, 0.07% of galaluminum and stirring for 20 minutes in a dispersant sorbitol having a mass percentage of 0.51%; and adding a mass percentage of 0.09%.
  • the cross-linking agent cross-linked povidone, 5% thickener sodium polyacrylate, 8.4% adhesive polyvinylpyrrolidone, 0.045% pH regulator tartaric acid and the balance of purified water, and stirred under vacuum for 5-8 min; Add active: 0.3% mint, 1% lavender essential oil, and vacuum stir for 5min, finally, the above materials are uniformly dispersed and mixed into a polymer sustained-release material containing active ingredients, and the polymer sustained-release material is coated on the anti-sticking material. On the layer, the preparation is prepared, and the attached preparation is attached to the backing layer, that is, the sedative and sedative.
  • An Shen Shu eye patch including an Anshen eye patch body, the body is composed of a backing layer, a polymer gel layer and a release layer, the release layer is composed of a polyethylene film and is located on the upper layer of the polymer gel layer, the backing The layer is located in the lower layer of the polymer gel layer, and the polymer gel layer is composed of the following mass percentage of raw materials and their ratios:
  • the pH regulator is tartaric acid
  • the polymer gel material includes dispersant sorbitol, humectant glycerin, cross-linking crospovidone, thickener sodium polyacrylate and adhesive polyvinylpyrrolidone.
  • the preparation method of the above-mentioned soothing eye patch comprises the following steps: adding 19% of humectant glycerin, 0.07% of galaluminum and stirring for 20 minutes in a dispersant sorbitol having a mass percentage of 0.5%; and adding 0.1% by mass.
  • the cross-linking agent cross-linked povidone, 4.5% thickener sodium polyacrylate, 8.4% adhesive polyvinylpyrrolidone, 0.05% pH regulator tartaric acid and the balance of purified water, and stirred under vacuum for 5-8 min;
  • the active substance is added: 0.2% mint, 1.2% lavender essential oil, and stirred under vacuum for 5 minutes.
  • the above materials are uniformly dispersed and mixed into a polymer sustained-release material containing an active ingredient, and the polymer sustained-release material is coated on the prevention.
  • the preparation is prepared, and then the attached preparation is attached to the backing layer, that is, the nerve is refreshed.
  • An Shen Shu eye patch including an Anshen eye patch body, the body is composed of a backing layer, a polymer gel layer and a release layer, the release layer is composed of a polyethylene film and is located on the upper layer of the polymer gel layer, the backing The layer is located in the lower layer of the polymer gel layer, and the polymer gel layer is composed of the following mass percentage of raw materials and their ratios:
  • the pH regulator is tartaric acid
  • the polymer gel material includes dispersant sorbitol, humectant glycerin, cross-linking crospovidone, thickener sodium polyacrylate and adhesive polyvinylpyrrolidone.
  • the preparation method of the above-mentioned Soothing Eye Patch comprises the following steps: adding 20% humectant glycerin, 0.08% galaluminum and stirring for 20 minutes in a dispersant sorbitol having a mass percentage of 0.5%; and adding 0.1% by mass.
  • the cross-linking agent cross-linked povidone, 5% thickener sodium polyacrylate, 8.4% adhesive polyvinylpyrrolidone, 0.05% pH regulator tartaric acid and the balance of purified water, and stirred under vacuum for 5-8 min;
  • the active substance is added: 0.2% mint, 1.3% lavender essential oil, and stirred under vacuum for 5 minutes, and finally the above materials are uniformly dispersed and mixed into a polymer sustained-release material containing an active ingredient, and the polymer sustained-release material is coated on the prevention On the adhesive layer, the preparation is prepared, and then the attached preparation is attached to the backing layer, that is, the nerve is refreshed.
  • An Shen Shu eye patch including an Anshen eye patch body, the body is composed of a backing layer, a polymer gel layer and a release layer, the release layer is composed of a polyethylene film and is located on the upper layer of the polymer gel layer, the backing The layer is located in the lower layer of the polymer gel layer, and the polymer gel layer is composed of the following mass percentage of raw materials and their ratios:
  • the pH regulator is tartaric acid
  • the polymer gel material includes dispersant sorbitol, humectant glycerin, cross-linking crospovidone, thickener sodium polyacrylate and adhesive polyvinylpyrrolidone.
  • the preparation method of the above-mentioned Soothing Eye Patch comprises the following steps: adding 18% humectant glycerin, 0.07% galaluminum and stirring for 20 minutes in a dispersing agent sorbitol having a mass percentage of 0.6%; and adding 0.1% by mass.
  • the cross-linking agent cross-linked povidone, 4.5% thickener sodium polyacrylate, 8.3% adhesive polyvinylpyrrolidone, 0.05% PH regulator tartaric acid and the balance of purified water, and stirred under vacuum for 5-8 min; Add active: 0.4% mint, 1.4% lavender essential oil, and vacuum stir for 5min.
  • the above materials are uniformly dispersed and mixed into a polymer sustained-release material containing active ingredients, and the polymer sustained-release material is coated on the anti-proof material.
  • the preparation is prepared, and then the attached preparation is attached to the backing layer, that is, the nerve is refreshed.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

A nerve-soothing and eye-relaxing patch and a preparation method therefor. The patch consists of a back lining layer, a polymer gel layer and an anti-sticking layer. The gel layer is prepared from the following raw materials in percentage by mass: 31 to 35 percent of polymer gel material, 0.07 to 0.08 percent of aluminum glycinate, 0.5 to 1.5 percent of lavender essential oil, 0.1 to 0.5 percent of mint, 0.04 to 0.05 percent of a PH regulator and the balance of pure water. The patch can effectively relieve symptoms of eye fatigue, eye distension, eye dryness and the like.

Description

安神舒眼贴及其制备方法Anshen Shu eye stick and preparation method thereof 技术领域Technical field
本发明涉及一种安神舒眼贴，还涉及一种安神舒眼贴的制备方法。The invention relates to an anti-soul eye patch, and relates to a preparation method of an anti-soul eye patch.
背景技术Background technique
对于上班族，经常需要长时间面对电脑，而且晚上需要熬夜，常常感到眼睛干涩发痒，总想用手揉眼睛，就会导致眼睛特别赤红、酸涩、肿胀，影响休息，眼部不适，出现眼疲劳，眼胀，眼干涩等症状。For office workers, they often need to face the computer for a long time, and they need to stay up late at night. They often feel dry and itchy eyes. They always want to rub their eyes with their hands, which will cause the eyes to be particularly red, sour, swollen, affecting rest, eye discomfort, and appearance. Eye fatigue, eye swelling, dry eyes and other symptoms.
发明内容Summary of the invention
为解决上述技术问题，本发明提供一种安神舒眼贴，既能安神舒睡，又能有效缓解眼疲劳等相关症状。In order to solve the above technical problems, the present invention provides an anti-soul eye patch, which can both calm and sleep, and can effectively alleviate related symptoms such as eye fatigue.
本发明还提供一种安神舒眼贴的制备方法。The invention also provides a preparation method of the soothing eye patch.
本发明采用的技术方案是：安神舒眼贴，包括安神舒眼贴本体，所述安神舒眼贴本体由背衬层、高分子凝胶层和防粘层组成，所述防粘层位于高分子凝胶层的上层，所述背衬层位于高分子凝胶层的下层，所述高分子凝胶层由以下质量百分比的原料及其配比组成：The technical solution adopted by the invention is: Anshen Shu eye patch, comprising Anshen Shu eye stick body, the Anshen Shu eye stick body is composed of a backing layer, a polymer gel layer and a release layer, the anti-adhesion layer is located at a high An upper layer of the molecular gel layer, the backing layer being located in a lower layer of the polymer gel layer, the polymer gel layer being composed of the following mass percentage of raw materials and a ratio thereof:
Figure PCTCN2015099076-appb-000001
Figure PCTCN2015099076-appb-000001
Figure PCTCN2015099076-appb-000002
Figure PCTCN2015099076-appb-000002
其中，所述PH调节剂为酒石酸，所述高分子凝胶材料包括分散剂、保湿剂、交联剂、增稠剂和黏附剂，所述分散剂为山梨醇，所述保湿剂为甘油，所述交联剂为交联聚维酮，所述黏附剂为聚乙烯吡咯烷酮，所述增稠剂为聚丙烯酸钠。Wherein the pH adjusting agent is tartaric acid, the polymer gel material comprises a dispersing agent, a humectant, a crosslinking agent, a thickener and an adhesive, the dispersing agent is sorbitol, and the humectant is glycerin. The crosslinking agent is crospovidone, the adhesion agent is polyvinylpyrrolidone, and the thickener is sodium polyacrylate.
所述防粘层由聚乙烯薄膜组成。The release layer is composed of a polyethylene film.
上述安神舒眼贴的制备方法，包括以下步骤：在质量百分比为0.42-0.6％的分散剂中加入18-20％的保湿剂、0.07-0.08％甘羟铝并搅拌20min；再加入质量百分比为0.08-0.1％的交联剂、4.2-5.5％的增稠剂、8.3-8.8％的黏附剂、0.04-0.05％的PH调节剂和余量的纯化水，并且真空搅拌5-8min；再加入活性物：0.1-0.5％薄荷、0.5-1.5％薰衣草精油，并且真空搅拌5min，最后上述物料均匀分散混合成含活性成分的高分子缓释材料，将高分子缓释材料涂布于防粘层上，制成附制剂，再将附制剂贴于背衬层上，即成安神舒眼贴。The preparation method of the above-mentioned soothing eye-protecting paste comprises the following steps: adding 18-20% humectant, 0.07-0.08% galaluminum and stirring for 20 min in a dispersing agent with a mass percentage of 0.42-0.6%; 0.08-0.1% of cross-linking agent, 4.2-5.5% thickener, 8.3-8.8% of adhesive, 0.04-0.05% of pH adjuster and the balance of purified water, and stirred under vacuum for 5-8min; Active substance: 0.1-0.5% mint, 0.5-1.5% lavender essential oil, and stirred under vacuum for 5 min, finally, the above materials are uniformly dispersed and mixed into a polymer sustained-release material containing active ingredients, and the polymer sustained-release material is coated on the release layer. On the top, the preparation is prepared, and the attached preparation is attached to the backing layer.
上述制备方法中，所述PH调节剂为酒石酸，所述高分子凝胶材料包括分散剂、保湿剂、交联剂、增稠剂和黏附剂，所述分散剂为山梨醇，所述保湿剂为甘油，所述交联剂为交联聚维酮，所述黏附剂为聚乙烯吡咯烷酮，所述增稠剂为聚丙烯酸钠。In the above preparation method, the pH adjusting agent is tartaric acid, and the polymer gel material comprises a dispersing agent, a moisturizing agent, a crosslinking agent, a thickener and an adhesive, the dispersing agent is sorbitol, and the moisturizing agent It is glycerin, the crosslinking agent is crospovidone, the adhesion agent is polyvinylpyrrolidone, and the thickener is sodium polyacrylate.
本发明的优点是：生产过程比较便捷，产品使用方便，符合日常生活所需，既能安神舒睡，又能有效缓解眼疲劳，眼胀，眼干涩等症状。The invention has the advantages that the production process is relatively convenient, the product is convenient to use, meets the needs of daily life, can not calm the eyes and sleep, and can effectively alleviate eye fatigue, eye swelling, dry eyes and other symptoms.
具体实施方式 detailed description
实施例1Example 1
安神舒眼贴，包括安神舒眼贴本体，该本体由背衬层、高分子凝胶层和防粘层组成，防粘层由聚乙烯薄膜组成并位于高分子凝胶层的上层，背衬层位于高分子凝胶层的下层，高分子凝胶层由以下质量百分比的原料及其配比组成：An Shen Shu eye patch, including an Anshen eye patch body, the body is composed of a backing layer, a polymer gel layer and a release layer, the release layer is composed of a polyethylene film and is located on the upper layer of the polymer gel layer, the backing The layer is located in the lower layer of the polymer gel layer, and the polymer gel layer is composed of the following mass percentage of raw materials and their ratios:
Figure PCTCN2015099076-appb-000003
Figure PCTCN2015099076-appb-000003
其中，PH调节剂为酒石酸，高分子凝胶材料包括分散剂山梨醇、保湿剂甘油、交联剂交联聚维酮、增稠剂聚丙烯酸钠和黏附剂聚乙烯吡咯烷酮，Among them, the pH regulator is tartaric acid, and the polymer gel material includes dispersant sorbitol, humectant glycerin, cross-linking crospovidone, thickener sodium polyacrylate and adhesive polyvinylpyrrolidone.
上述安神舒眼贴的制备方法，包括以下步骤：在质量百分比为0.42％的分散剂山梨醇中加入18％的保湿剂甘油、0.07％甘羟铝并搅拌20min；再加入质量百分比为0.08％的交联剂交联聚维酮、4.2％的增稠剂聚丙烯酸钠、8.3％的黏附剂聚乙烯吡咯烷酮、0.04％的PH调节剂酒石酸和余量的纯化水，并且真空搅拌5-8min；再加入活性物：0.1％薄荷、0.5％薰衣草精油，并且真空搅拌5min，最后上述物料均匀分散混合成含活性成分的高分子缓释材料，将高分子缓释材料涂布于防粘层上，制成附制剂，再将附制剂贴于背衬层上，即成安神舒眼 贴。The preparation method of the above-mentioned Soothing Eye Mask comprises the following steps: adding 18% humectant glycerin, 0.07% galaluminum and stirring for 20 minutes in a dispersant sorbitol having a mass percentage of 0.42%; and adding a mass percentage of 0.08%. The cross-linking agent cross-linked povidone, 4.2% thickener sodium polyacrylate, 8.3% adhesive polyvinylpyrrolidone, 0.04% pH regulator tartaric acid and the balance of purified water, and stirred under vacuum for 5-8 min; The active substance is added: 0.1% mint, 0.5% lavender essential oil, and stirred under vacuum for 5 minutes. Finally, the above materials are uniformly dispersed and mixed into a polymer sustained-release material containing an active ingredient, and the polymer sustained-release material is coated on the release layer. Adding the preparation, and then attaching the preparation to the backing layer paste.
实施例2Example 2
安神舒眼贴，包括安神舒眼贴本体，该本体由背衬层、高分子凝胶层和防粘层组成，防粘层由聚乙烯薄膜组成并位于高分子凝胶层的上层，背衬层位于高分子凝胶层的下层，高分子凝胶层由以下质量百分比的原料及其配比组成：An Shen Shu eye patch, including an Anshen eye patch body, the body is composed of a backing layer, a polymer gel layer and a release layer, the release layer is composed of a polyethylene film and is located on the upper layer of the polymer gel layer, the backing The layer is located in the lower layer of the polymer gel layer, and the polymer gel layer is composed of the following mass percentage of raw materials and their ratios:
Figure PCTCN2015099076-appb-000004
Figure PCTCN2015099076-appb-000004
其中，PH调节剂为酒石酸，高分子凝胶材料包括分散剂山梨醇、保湿剂甘油、交联剂交联聚维酮、增稠剂聚丙烯酸钠和黏附剂聚乙烯吡咯烷酮，Among them, the pH regulator is tartaric acid, and the polymer gel material includes dispersant sorbitol, humectant glycerin, cross-linking crospovidone, thickener sodium polyacrylate and adhesive polyvinylpyrrolidone.
上述安神舒眼贴的制备方法，包括以下步骤：在质量百分比为0.6％的分散剂山梨醇中加入20％的保湿剂甘油、0.08％甘羟铝并搅拌20min；再加入质量百分比为0.1％的交联剂交联聚维酮、5.5％的增稠剂聚丙烯酸钠、8.8％的黏附剂聚乙烯吡咯烷酮、0.05％的PH调节剂酒石酸和余量的纯化水，并且真空搅拌5-8min；再加入活性物：0.5％薄荷、1.5％薰衣草精油，并且真空搅拌5min，最后上述物料均匀分散混合成含活性成分的高分子缓释材料，将高分子缓释材料涂布于防 粘层上，制成附制剂，再将附制剂贴于背衬层上，即成安神舒眼贴。The preparation method of the above-mentioned Soothing Eye Mask comprises the following steps: adding 20% humectant glycerin, 0.08% galaluminum and stirring for 20 minutes in a dispersant sorbitol having a mass percentage of 0.6%; and adding 0.1% by mass. The cross-linking agent cross-linked povidone, 5.5% thickener sodium polyacrylate, 8.8% adhesive polyvinylpyrrolidone, 0.05% PH regulator tartaric acid and the balance of purified water, and stirred under vacuum for 5-8 min; Add active: 0.5% mint, 1.5% lavender essential oil, and stir for 5 minutes under vacuum. Finally, the above materials are uniformly dispersed and mixed into a polymer sustained-release material containing active ingredients, and the polymer sustained-release material is coated on the prevention. On the adhesive layer, the preparation is prepared, and then the attached preparation is attached to the backing layer, that is, the nerve is refreshed.
实施例3Example 3
安神舒眼贴，包括安神舒眼贴本体，该本体由背衬层、高分子凝胶层和防粘层组成，防粘层由聚乙烯薄膜组成并位于高分子凝胶层的上层，背衬层位于高分子凝胶层的下层，高分子凝胶层由以下质量百分比的原料及其配比组成：An Shen Shu eye patch, including an Anshen eye patch body, the body is composed of a backing layer, a polymer gel layer and a release layer, the release layer is composed of a polyethylene film and is located on the upper layer of the polymer gel layer, the backing The layer is located in the lower layer of the polymer gel layer, and the polymer gel layer is composed of the following mass percentage of raw materials and their ratios:
Figure PCTCN2015099076-appb-000005
Figure PCTCN2015099076-appb-000005
其中，PH调节剂为酒石酸，高分子凝胶材料包括分散剂山梨醇、保湿剂甘油、交联剂交联聚维酮、增稠剂聚丙烯酸钠和黏附剂聚乙烯吡咯烷酮，Among them, the pH regulator is tartaric acid, and the polymer gel material includes dispersant sorbitol, humectant glycerin, cross-linking crospovidone, thickener sodium polyacrylate and adhesive polyvinylpyrrolidone.
上述安神舒眼贴的制备方法，包括以下步骤：在质量百分比为0.51％的分散剂山梨醇中加入19％的保湿剂甘油、0.07％甘羟铝并搅拌20min；再加入质量百分比为0.09％的交联剂交联聚维酮、5％的增稠剂聚丙烯酸钠、8.4％的黏附剂聚乙烯吡咯烷酮、0.045％的PH调节剂酒石酸和余量的纯化水，并且真空搅拌5-8min；再加入活性物：0.3％薄荷、1％薰衣草精油，并且真空搅拌5min，最后上述物料均匀分散混合成含活性成分的高分子缓释材料，将高分子缓释材料涂布于防粘 层上，制成附制剂，再将附制剂贴于背衬层上，即成安神舒眼贴。实施例4The preparation method of the above-mentioned Soothing Eye Patch comprises the following steps: adding 19% of humectant glycerin, 0.07% of galaluminum and stirring for 20 minutes in a dispersant sorbitol having a mass percentage of 0.51%; and adding a mass percentage of 0.09%. The cross-linking agent cross-linked povidone, 5% thickener sodium polyacrylate, 8.4% adhesive polyvinylpyrrolidone, 0.045% pH regulator tartaric acid and the balance of purified water, and stirred under vacuum for 5-8 min; Add active: 0.3% mint, 1% lavender essential oil, and vacuum stir for 5min, finally, the above materials are uniformly dispersed and mixed into a polymer sustained-release material containing active ingredients, and the polymer sustained-release material is coated on the anti-sticking material. On the layer, the preparation is prepared, and the attached preparation is attached to the backing layer, that is, the sedative and sedative. Example 4
安神舒眼贴，包括安神舒眼贴本体，该本体由背衬层、高分子凝胶层和防粘层组成，防粘层由聚乙烯薄膜组成并位于高分子凝胶层的上层，背衬层位于高分子凝胶层的下层，高分子凝胶层由以下质量百分比的原料及其配比组成：An Shen Shu eye patch, including an Anshen eye patch body, the body is composed of a backing layer, a polymer gel layer and a release layer, the release layer is composed of a polyethylene film and is located on the upper layer of the polymer gel layer, the backing The layer is located in the lower layer of the polymer gel layer, and the polymer gel layer is composed of the following mass percentage of raw materials and their ratios:
Figure PCTCN2015099076-appb-000006
Figure PCTCN2015099076-appb-000006
其中，PH调节剂为酒石酸，高分子凝胶材料包括分散剂山梨醇、保湿剂甘油、交联剂交联聚维酮、增稠剂聚丙烯酸钠和黏附剂聚乙烯吡咯烷酮，Among them, the pH regulator is tartaric acid, and the polymer gel material includes dispersant sorbitol, humectant glycerin, cross-linking crospovidone, thickener sodium polyacrylate and adhesive polyvinylpyrrolidone.
上述安神舒眼贴的制备方法，包括以下步骤：在质量百分比为0.5％的分散剂山梨醇中加入19％的保湿剂甘油、0.07％甘羟铝并搅拌20min；再加入质量百分比为0.1％的交联剂交联聚维酮、4.5％的增稠剂聚丙烯酸钠、8.4％的黏附剂聚乙烯吡咯烷酮、0.05％的PH调节剂酒石酸和余量的纯化水，并且真空搅拌5-8min；再加入活性物：0.2％薄荷、1.2％薰衣草精油，并且真空搅拌5min，最后上述物料均匀分散混合成含活性成分的高分子缓释材料，将高分子缓释材料涂布于防 粘层上，制成附制剂，再将附制剂贴于背衬层上，即成安神舒眼贴。The preparation method of the above-mentioned soothing eye patch comprises the following steps: adding 19% of humectant glycerin, 0.07% of galaluminum and stirring for 20 minutes in a dispersant sorbitol having a mass percentage of 0.5%; and adding 0.1% by mass. The cross-linking agent cross-linked povidone, 4.5% thickener sodium polyacrylate, 8.4% adhesive polyvinylpyrrolidone, 0.05% pH regulator tartaric acid and the balance of purified water, and stirred under vacuum for 5-8 min; The active substance is added: 0.2% mint, 1.2% lavender essential oil, and stirred under vacuum for 5 minutes. Finally, the above materials are uniformly dispersed and mixed into a polymer sustained-release material containing an active ingredient, and the polymer sustained-release material is coated on the prevention. On the adhesive layer, the preparation is prepared, and then the attached preparation is attached to the backing layer, that is, the nerve is refreshed.
实施例5Example 5
安神舒眼贴，包括安神舒眼贴本体，该本体由背衬层、高分子凝胶层和防粘层组成，防粘层由聚乙烯薄膜组成并位于高分子凝胶层的上层，背衬层位于高分子凝胶层的下层，高分子凝胶层由以下质量百分比的原料及其配比组成：An Shen Shu eye patch, including an Anshen eye patch body, the body is composed of a backing layer, a polymer gel layer and a release layer, the release layer is composed of a polyethylene film and is located on the upper layer of the polymer gel layer, the backing The layer is located in the lower layer of the polymer gel layer, and the polymer gel layer is composed of the following mass percentage of raw materials and their ratios:
Figure PCTCN2015099076-appb-000007
Figure PCTCN2015099076-appb-000007
其中，PH调节剂为酒石酸，高分子凝胶材料包括分散剂山梨醇、保湿剂甘油、交联剂交联聚维酮、增稠剂聚丙烯酸钠和黏附剂聚乙烯吡咯烷酮，Among them, the pH regulator is tartaric acid, and the polymer gel material includes dispersant sorbitol, humectant glycerin, cross-linking crospovidone, thickener sodium polyacrylate and adhesive polyvinylpyrrolidone.
上述安神舒眼贴的制备方法，包括以下步骤：在质量百分比为0.5％的分散剂山梨醇中加入20％的保湿剂甘油、0.08％甘羟铝并搅拌20min；再加入质量百分比为0.1％的交联剂交联聚维酮、5％的增稠剂聚丙烯酸钠、8.4％的黏附剂聚乙烯吡咯烷酮、0.05％的PH调节剂酒石酸和余量的纯化水，并且真空搅拌5-8min；再加入活性物：0.2％薄荷、1.3％薰衣草精油，并且真空搅拌5min，最后上述物料均匀分散混合成含活性成分的高分子缓释材料，将高分子缓释材料涂布于防 粘层上，制成附制剂，再将附制剂贴于背衬层上，即成安神舒眼贴。The preparation method of the above-mentioned Soothing Eye Patch comprises the following steps: adding 20% humectant glycerin, 0.08% galaluminum and stirring for 20 minutes in a dispersant sorbitol having a mass percentage of 0.5%; and adding 0.1% by mass. The cross-linking agent cross-linked povidone, 5% thickener sodium polyacrylate, 8.4% adhesive polyvinylpyrrolidone, 0.05% pH regulator tartaric acid and the balance of purified water, and stirred under vacuum for 5-8 min; The active substance is added: 0.2% mint, 1.3% lavender essential oil, and stirred under vacuum for 5 minutes, and finally the above materials are uniformly dispersed and mixed into a polymer sustained-release material containing an active ingredient, and the polymer sustained-release material is coated on the prevention On the adhesive layer, the preparation is prepared, and then the attached preparation is attached to the backing layer, that is, the nerve is refreshed.
实施例6Example 6
安神舒眼贴，包括安神舒眼贴本体，该本体由背衬层、高分子凝胶层和防粘层组成，防粘层由聚乙烯薄膜组成并位于高分子凝胶层的上层，背衬层位于高分子凝胶层的下层，高分子凝胶层由以下质量百分比的原料及其配比组成：An Shen Shu eye patch, including an Anshen eye patch body, the body is composed of a backing layer, a polymer gel layer and a release layer, the release layer is composed of a polyethylene film and is located on the upper layer of the polymer gel layer, the backing The layer is located in the lower layer of the polymer gel layer, and the polymer gel layer is composed of the following mass percentage of raw materials and their ratios:
Figure PCTCN2015099076-appb-000008
Figure PCTCN2015099076-appb-000008
其中，PH调节剂为酒石酸，高分子凝胶材料包括分散剂山梨醇、保湿剂甘油、交联剂交联聚维酮、增稠剂聚丙烯酸钠和黏附剂聚乙烯吡咯烷酮，Among them, the pH regulator is tartaric acid, and the polymer gel material includes dispersant sorbitol, humectant glycerin, cross-linking crospovidone, thickener sodium polyacrylate and adhesive polyvinylpyrrolidone.
上述安神舒眼贴的制备方法，包括以下步骤：在质量百分比为0.6％的分散剂山梨醇中加入18％的保湿剂甘油、0.07％甘羟铝并搅拌20min；再加入质量百分比为0.1％的交联剂交联聚维酮、4.5％的增稠剂聚丙烯酸钠、8.3％的黏附剂聚乙烯吡咯烷酮、0.05％的PH调节剂酒石酸和余量的纯化水，并且真空搅拌5-8min；再加入活性物：0.4％薄荷、1.4％薰衣草精油，并且真空搅拌5min，最后上述物料均匀分散混合成含活性成分的高分子缓释材料，将高分子缓释材料涂布于防 粘层上，制成附制剂，再将附制剂贴于背衬层上，即成安神舒眼贴。 The preparation method of the above-mentioned Soothing Eye Patch comprises the following steps: adding 18% humectant glycerin, 0.07% galaluminum and stirring for 20 minutes in a dispersing agent sorbitol having a mass percentage of 0.6%; and adding 0.1% by mass. The cross-linking agent cross-linked povidone, 4.5% thickener sodium polyacrylate, 8.3% adhesive polyvinylpyrrolidone, 0.05% PH regulator tartaric acid and the balance of purified water, and stirred under vacuum for 5-8 min; Add active: 0.4% mint, 1.4% lavender essential oil, and vacuum stir for 5min. Finally, the above materials are uniformly dispersed and mixed into a polymer sustained-release material containing active ingredients, and the polymer sustained-release material is coated on the anti-proof material. On the adhesive layer, the preparation is prepared, and then the attached preparation is attached to the backing layer, that is, the nerve is refreshed.

Claims (4)

  1. 安神舒眼贴，包括安神舒眼贴本体，其特征在于：所述安神舒眼贴本体由背衬层、高分子凝胶层和防粘层组成，所述防粘层位于高分子凝胶层的上层，所述背衬层位于高分子凝胶层的下层，所述高分子凝胶层由以下质量百分比的原料及其配比组成：An sedative eye patch, comprising an Anshen smear body, wherein the sedative body consists of a backing layer, a polymer gel layer and a release layer, the release layer being located in the polymer gel layer In the upper layer, the backing layer is located in a lower layer of the polymer gel layer, and the polymer gel layer is composed of the following mass percentage of raw materials and their ratios:
    Figure PCTCN2015099076-appb-100001
    Figure PCTCN2015099076-appb-100001
    其中，所述PH调节剂为酒石酸，所述高分子凝胶材料包括分散剂、保湿剂、交联剂、增稠剂和黏附剂，所述分散剂为山梨醇，所述保湿剂为甘油，所述交联剂为交联聚维酮，所述黏附剂为聚乙烯吡咯烷酮，所述增稠剂为聚丙烯酸钠。Wherein the pH adjusting agent is tartaric acid, the polymer gel material comprises a dispersing agent, a humectant, a crosslinking agent, a thickener and an adhesive, the dispersing agent is sorbitol, and the humectant is glycerin. The crosslinking agent is crospovidone, the adhesion agent is polyvinylpyrrolidone, and the thickener is sodium polyacrylate.
  2. 根据权利要求1所述的安神舒眼贴，其特征在于：所述防粘层由聚乙烯薄膜组成。The sedative patch according to claim 1, wherein the release layer is composed of a polyethylene film.
  3. 一种如权利要求1所述的安神舒眼贴的制备方法，其特征在于：包括以下步骤：在质量百分比为0.42-0.6％的分散剂中加入18-20％的保湿剂、0.07-0.08％甘羟铝并搅拌20min；再加入质量百分比为0.08-0.1％的交联剂、4.2-5.5％的增稠剂、8.3-8.8％的黏附剂、0.04-0.05％的PH调节剂和余量的纯化水，并且真空搅拌5-8min； 再加入活性物：0.1-0.5％薄荷、0.5-1.5％薰衣草精油，并且真空搅拌5min，最后上述物料均匀分散混合成含活性成分的高分子缓释材料，将高分子缓释材料涂布于防粘层上，制成附制剂，再将附制剂贴于背衬层上，即成安神舒眼贴。A method for preparing a refreshing eye patch according to claim 1, comprising the steps of: adding 18-20% of a humectant, 0.07-0.08% to a dispersant having a mass percentage of 0.42-0.6%; Glycol aluminum and stirred for 20 min; add 0.08-0.1% by mass of cross-linking agent, 4.2-5.5% thickener, 8.3-8.8% of adhesive, 0.04-0.05% of pH adjuster and balance Purify the water and stir it under vacuum for 5-8 min; Add active material: 0.1-0.5% mint, 0.5-1.5% lavender essential oil, and vacuum stirring for 5min, finally, the above materials are uniformly dispersed and mixed into a polymer sustained-release material containing active ingredients, and the polymer sustained-release material is coated on the anti-proof material. On the adhesive layer, the preparation is prepared, and then the attached preparation is attached to the backing layer, that is, the nerve is refreshed.
  4. 一种如权利要求3所述的安神舒眼贴的制备方法，其特征在于，所述PH调节剂为酒石酸，所述高分子凝胶材料包括分散剂、保湿剂、交联剂、增稠剂和黏附剂，所述分散剂为山梨醇，所述保湿剂为甘油，所述交联剂为交联聚维酮，所述黏附剂为聚乙烯吡咯烷酮，所述增稠剂为聚丙烯酸钠。 A method for preparing an anti-soul patch according to claim 3, wherein the pH adjusting agent is tartaric acid, and the polymer gel material comprises a dispersing agent, a moisturizing agent, a crosslinking agent, and a thickener. And an adhesive, the dispersing agent is sorbitol, the humectant is glycerin, the crosslinking agent is crospovidone, the adhesive is polyvinylpyrrolidone, and the thickener is sodium polyacrylate.
PCT/CN2015/099076 2015-03-12 2015-12-25 Nerve-soothing and eye-relaxing patch and preparation method therefor WO2016141757A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510108232.3A CN104688813A (en) 2015-03-12 2015-03-12 Nerve-soothing and eye-relaxing pad and preparation method thereof
CN201510108232.3 2015-03-12

Publications (1)

Publication Number Publication Date
WO2016141757A1 true WO2016141757A1 (en) 2016-09-15

Family

ID=53336637

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2015/099076 WO2016141757A1 (en) 2015-03-12 2015-12-25 Nerve-soothing and eye-relaxing patch and preparation method therefor

Country Status (2)

Country Link
CN (1) CN104688813A (en)
WO (1) WO2016141757A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110327312A (en) * 2019-08-23 2019-10-15 重庆万寿健康管理有限公司 A kind of pure Chinese medicine quantum eye paste

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104706768A (en) * 2015-03-12 2015-06-17 施敬东 Patch capable of calming nerves and helping sleep and preparation method of patch
CN104688813A (en) * 2015-03-12 2015-06-10 施敬东 Nerve-soothing and eye-relaxing pad and preparation method thereof
CN105213087A (en) * 2015-09-24 2016-01-06 江门市新时代外用制剂有限公司 One is defervescence plaster used and preparation method thereof
CN105381010A (en) * 2015-12-02 2016-03-09 山东朱氏药业集团有限公司 Disposable medical hydrogel eye mask
CN111434345A (en) * 2019-01-11 2020-07-21 广州一株艾保健科技有限公司 Formula and preparation process of moxa essential oil for relieving asthenopia
CN110141560A (en) * 2019-06-28 2019-08-20 广州市白云区大荣精细化工有限公司 A kind of Medical cold application and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101721486A (en) * 2008-11-03 2010-06-09 孙臻 Eye guard for treating insomnia and preparation method thereof
CN103239428A (en) * 2013-05-27 2013-08-14 施敬东 Contraceptive patch and preparation method thereof
CN104688813A (en) * 2015-03-12 2015-06-10 施敬东 Nerve-soothing and eye-relaxing pad and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103110474A (en) * 2011-11-16 2013-05-22 吴克 Eye fatigue special pad
CN103316078B (en) * 2013-06-18 2015-01-14 安徽万邦医药科技有限公司 Sleep aiding and cooling patch and preparation method thereof
CN104116843A (en) * 2014-06-30 2014-10-29 李星明 Pasting pad for protecting eyeballs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101721486A (en) * 2008-11-03 2010-06-09 孙臻 Eye guard for treating insomnia and preparation method thereof
CN103239428A (en) * 2013-05-27 2013-08-14 施敬东 Contraceptive patch and preparation method thereof
CN104688813A (en) * 2015-03-12 2015-06-10 施敬东 Nerve-soothing and eye-relaxing pad and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WANG, GUANGYAO.: "Advances in the Research and the Development of Plant Essential Oils", FOOD SCIENCE AND TECHNOLOGY, 20 May 2006 (2006-05-20) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110327312A (en) * 2019-08-23 2019-10-15 重庆万寿健康管理有限公司 A kind of pure Chinese medicine quantum eye paste

Also Published As

Publication number Publication date
CN104688813A (en) 2015-06-10

Similar Documents

Publication Publication Date Title
WO2016141757A1 (en) Nerve-soothing and eye-relaxing patch and preparation method therefor
WO2016141755A1 (en) Medical defervescence patch and preparation method therefor
WO2016141754A1 (en) Nerve-soothing and sleep-aiding patch and preparation method therefor
CN109627512A (en) Sole ultralight graphene rubber pange micelle and preparation method thereof
WO2016141756A1 (en) Headache-relieving patch and preparation method therefor
JP5089933B2 (en) Water-containing pressure-sensitive adhesive composition and patch using the same
WO2016141758A1 (en) Refreshing and cooling patch and preparation method therefor
WO2019211873A3 (en) A liquid cornea composition
CN110546189A (en) Method for producing hydrogel
TWI520733B (en) Contains lidocaine gel preparations
KR20060017760A (en) Anti-inflammatory analgesic adhesive patch
CN102561103B (en) Production technology of household paper with moisturizing functions
CN106700747A (en) Single-component waterproof paint composition and preparation method thereof
CN106974760A (en) A kind of spontaneous heat pad blanket
KR20100014511A (en) Poultice and process for producing the poultice
CN107737033A (en) A kind of quick anti-acne and anti-acne print composition and preparation method thereof
CN205054577U (en) Disconnect -type spontaneous heating eye -shade
CN1883450A (en) A hydrophilic gel plaster substrate
CN106619481B (en) Long-acting 5-HT1A receptor agonist and preparation method thereof
US11850220B2 (en) Synthesis of ibuprofen hybrid conjugates as anti-inflammatory and analgesic agents
CN1068731A (en) Cosmetic gel
CN108159007A (en) A kind of body of Pramipexole dihydrochloride sustained release preparation and preparation method thereof
CN102877308A (en) Water-based PU surface passivator for artificial leather
JP2005075755A (en) Antiphlogistic-sedative plaster and method for producing the same
JP3478865B2 (en) Hydrogel plaster

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15884435

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 15884435

Country of ref document: EP

Kind code of ref document: A1