CN108175796A - A kind of graphene sustained release headache patch and preparation method thereof - Google Patents
A kind of graphene sustained release headache patch and preparation method thereof Download PDFInfo
- Publication number
- CN108175796A CN108175796A CN201810152406.XA CN201810152406A CN108175796A CN 108175796 A CN108175796 A CN 108175796A CN 201810152406 A CN201810152406 A CN 201810152406A CN 108175796 A CN108175796 A CN 108175796A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- graphene
- headache
- pharmaceutical chemicals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of graphenes to be sustained headache patch, including back sheet, drug effect layer and adherent layer, the drug effect is placed on the top of back sheet, the anti-sticking lower section for being placed on back sheet, it is the bulk pharmaceutical chemicals for the treatment of headache in the centre position of drug effect layer, the bulk pharmaceutical chemicals include the semen litchi for hot promoting blood circulation and stopping pain of dispelling, kamuning, Rhizoma Chuanxiong, safflower, the root of Dahurain angelica, Peppermint essential oil and lemon, the outer surface of the bulk pharmaceutical chemicals is included by functional grapheme material, to prevent medicine group from gathering, improve the dissolubility of drug, graphene sustained release headache patch is convenient to use, it is administered by way of Cutaneous permeation, functional property graphene is included in the outer surface of bulk pharmaceutical chemicals, it is effectively improved the effect of drugs of bulk pharmaceutical chemicals, the dissolubility and aggregation extent of drug, drug plays one's part to the full, drug effect is significantly improved.
Description
Technical field
The present invention relates to a kind of drug paste, specially a kind of graphene sustained release headache patch and preparation method thereof field.
Background technology
With the fast development and the improvement of people's living standards of China's economy, people’s lives pressure is also gradually increasing
Greatly, headache, dizziness and the symptoms such as dizzy are often will appear in nervous working and learning life, clinically according to headache onset
Mode can be divided into：The having a headache of Acute onset, the headache of subacute onset and the headache of slow Acute onset.
However, the mechanism of headache onset is sufficiently complex, extremely easily breaking-out, when encountering, excited, diet is irregular, stops
Headache can all be induced or aggravate headache by ceasing bad and while overworking, be such as not treated in time, and not only be had a headache unbearably but also can
Can cause the generations of other diseases, in order to alleviate and cure headache, people usually use kinesiatrics, aromatotherapy and in
The method of western medical treatment since kinesiatrics and aromatotherapy are merely capable of alleviating the state of an illness, works slow, so encountering headache
It can be generally gone during symptom by taking traditional Chinese medicine or Western medicine treats headache, but the taste of Chinese medicine is bitter, Western medicine can cause body
Certain injury, so there is many patients that drug paste is taken to treat, and current drug paste is due to during administration, drug it is molten
Poor permeability is solved, easily reunites, leads to the drug effect of drug to reduce.
Therefore, how sustained release headache patch is improved, it is made to overcome disadvantages mentioned above that can have the advantages that again certain, be this
A field technology personnel problem urgently to be resolved hurrily.
Invention content
It is a kind of convenient to use it is a primary object of the present invention to provide, it prevents drug from reuniting, effectively plays drug effect, allow
Graphene sustained release headache patch that patient with headache can be cured as early as possible and preparation method thereof.
To achieve the above objectives, the technical solution adopted by the present invention is：A kind of graphene sustained release headache patch, including backing
Layer, drug effect layer and adherent layer, the drug effect are placed on the top of back sheet, the anti-sticking lower section for being placed on back sheet, in drug effect layer
Centre position be treatment headache bulk pharmaceutical chemicals, the bulk pharmaceutical chemicals include dispelling the semen litchi of hot promoting blood circulation and stopping pain, Rhizoma Chuanxiong, safflower, white
The root of Dahurian angelica, Peppermint essential oil and lemon, the outer surface of the bulk pharmaceutical chemicals is included by functional grapheme material, to prevent medicine group
Dissolubility that is poly-, improving drug.
The upper surface of the drug effect layer is also equipped with Macromolecule glue-line, and material is poly- third used by Macromolecule glue-line
Olefin(e) acid sodium, polyvinylpyrrolidone, glycerine, medical ethanol, eucalyptus leaf essential oil and high purity water.
As a further improvement, the bulk pharmaceutical chemicals include following parts by weight：Semen litchi 10-15 parts by weight, kamuning 10-15
Parts by weight, Rhizoma Chuanxiong 5-10 parts by weight, safflower 5-10 parts by weight, root of Dahurain angelica 15-20 parts by weight, Peppermint essential oil 5-10 parts by weight, lemon
Essential oil 5-10 parts by weight, functional graphene 15-25 parts by weight, the material in the Macromolecule glue-line include following weight
Part：Sodium Polyacrylate 15-20 parts by weight, polyvinylpyrrolidone 15-20 parts by weight, glycerine 3-5 parts by weight, medical ethanol 3-5
Parts by weight, eucalyptus leaf essential oil 3-5 parts by weight and high purity water 35-45 parts by weight.
As a further improvement, the bulk pharmaceutical chemicals include following parts by weight：12 parts by weight of semen litchi, 12 weight of kamuning
Part, 8 parts by weight of Rhizoma Chuanxiong, 8 parts by weight of safflower, 18 parts by weight of the root of Dahurain angelica, 8 parts by weight of Peppermint essential oil, 6 parts by weight of lemon, function
Property 20 parts by weight of graphene, the material in the Macromolecule glue-line includes following parts by weight：18 parts by weight of Sodium Polyacrylate are gathered
18 parts by weight of vinylpyrrolidone, 4 parts by weight of glycerine, 4 parts by weight of medical ethanol, 4 parts by weight of eucalyptus leaf essential oil and high purity water 40
Parts by weight.
As an improvement, the average grain diameter of the bulk pharmaceutical chemicals of the functionality graphene inclusion is 115-125 nanometers.
The second object of the present invention is the production method for providing a kind of graphene joint pain patch, is included the following steps：
S1 weighs following bulk pharmaceutical chemicals by formula ratio：12 parts by weight of semen litchi, 12 parts by weight of kamuning, 8 parts by weight of Rhizoma Chuanxiong,
8 parts by weight of safflower, 18 parts by weight of the root of Dahurain angelica；
S2, after the bulk pharmaceutical chemicals are pulverized, sieving adds in 6 parts by weight of 8 parts by weight of Peppermint essential oil and lemon,
It is stirred under vacuum, wherein whipping temp is 30-50 degrees Celsius, and mixing time is 48-72 hours；
S3, graphene nano material made from graphite powder hydro-thermal method is dried, and 20 parts by weight is weighed according to formula ratio, with S2
In it is brewed after bulk pharmaceutical chemicals be mutually mixed, be placed in Vltrasonic device abundant ultrasound 3-5 hour, after it is ultrasonic uniformly after, original will be reacted
Material is transferred to can be in heating and stirring device, and heating stirring, wherein heating temperature are 50-70 degrees Celsius, mixing time 72-108
Hour, obtain the bulk pharmaceutical chemicals of functional graphene inclusion；
S4, by Macromolecule glue material according to following parts by weight：18 parts by weight of Sodium Polyacrylate, polyvinylpyrrolidone 18
Parts by weight, 4 parts by weight of glycerine are sufficiently mixed stirring 30 minutes, add in 4 parts by weight of medical ethanol, 4 parts by weight of eucalyptus leaf essential oil, vacuum
It is mixed 5-10 minutes, then adds in high purity water 40 minutes, it is brewed in 50-70 degrees Celsius of sealing after being sufficiently mixed uniformly
5-8 hours, secured satisfactory grades sub- material layer；
Polymer material layer in S4 is uniformly applied to the surface of back sheet by S5；
The bulk pharmaceutical chemicals that the functional graphene obtained in S3 includes uniformly are spun on polymer material layer in S5 by S6
Top, then with adherent layer bedding on its surface, you can obtain graphene sustained release headache patch
Preferably, whipping temp is 45 degrees Celsius in the S2, and brew time is 60 hours.
Preferably, it is 60 degrees Celsius that brewing temperature is sealed in the S4, and the tanning time is 6 hours.
Wherein, semen litchi is the dry mature seed of sapindaceous plant lichee, and summer harvesting ripe fruit removes pericarp
It with meat aril, cleans, dries, gas is micro-, taste micro-sweet, hardship, puckery, has the effect of going to a winter resort evil, analgesic.
Kamuning, dungarunga is high up to 8 meters, branch lime or yellowish grey, but annual shoot green, leaf have leaflet 3-
5-7, leaflet obovate or obovate elliptic, both sides are often asymmetric, acrid flavour, and slight bitter is warm-natured, mild toxicity, there is local anaesthesia work
With.
Rhizoma Chuanxiong, cultivated plant, main product on Yunnan, Guizhou, Guangxi and other places, are grown on mild weather in Sichuan (Guanxian county)
Environment.It is a kind of Chinese medicinal plant, is usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, effectiveness is favourable.
Safflower, composite family, safflower platymiscium, dry tubular flower is orange red, and floral tube is narrow thin, and apex 5 is split, and sliver is narrow linear,
Anther yellow, is unified into pipe, is higher by except sliver, and there is column cap exposing in center, has special fragrance, and mildly bitter flavor has invigorate blood circulation,
The effect of removing blood stasis and analgesics.
The root of Dahurain angelica, perennial tall and big draft is 1-2.5 meters high, and root is cylindrical, and 2-5 centimetres of basal part of stem diameter, basal leaf one returns pinniform
Division, universal umbel basidixed or side life, fruit oblong to oval are used as medicine with root, the dehumidifying that gets rid of illness, apocenosis myogenic, work
The functions such as blood and relieving pain.
Peppermint essential oil, the ingredient that peppermint is distilled by water or subcritical low-temperature extraction goes out, mint flavored are clearly cooled off oneself, and the mind is shaken
It puts forth energy, relieveing pain and refreshing can mitigate headache, migraine.
Lemon, aromatic odor, weak yellow liquid, the fragrance of citrus is salubrious and fresh, has and consoles and alleviate head
The effect of pain and migraines.
Beneficial effects of the present invention are as follows：
Graphene sustained release headache patch provided by the invention, by using Chinese medicines such as semen litchi, Rhizoma Chuanxiong, safflower and the roots of Dahurain angelica
Material has good healing effect, and injury will not be brought to human body, by adding in Peppermint essential oil and lemon extract for headache
The plants essential oils such as oil not only have effects that the headache that refreshes the mind, releives, but also can dissolve bulk pharmaceutical chemicals in certain degree,
By being laid with Macromolecule glue material in the top of bulk pharmaceutical chemicals layer, bulk pharmaceutical chemicals can effectively be accelerated to penetrate into lower layers of skin, promoted
Into the absorption of bulk pharmaceutical chemicals, a layer graphene is wrapped up in the outer surface of bulk pharmaceutical chemicals, the dissolubility of drug is effectively improved, prevents medicine
Object settles and aggregation, improves medical surfaces performance, extends efficacy time, ensures the effect of drug effect.
Description of the drawings
Fig. 1 is graphene sustained release headache patch preparation method flow chart；
Fig. 2 is the electron microscope of the bulk pharmaceutical chemicals of graphene package；
Fig. 3 is the electron microscope of the bulk pharmaceutical chemicals wrapped up without graphene；
Fig. 4 is the sedimentation ratio chart of the bulk pharmaceutical chemicals of graphene package；
Fig. 5 is the sedimentation ratio chart of the bulk pharmaceutical chemicals wrapped up without graphene.
Specific embodiment
It is described below to disclose the present invention so that those skilled in the art can realize the present invention.It is excellent in being described below
Embodiment is selected to be only used as illustrating, it may occur to persons skilled in the art that other obvious modifications.
Prepare Solution Embodiments 1：
Formula：
It is 12 parts by weight of semen litchi, 12 parts by weight of kamuning, 8 parts by weight of Rhizoma Chuanxiong, 8 parts by weight of safflower, 18 parts by weight of the root of Dahurain angelica, thin
8 parts by weight of lotus essential oil, 6 parts by weight of lemon, 20 parts by weight of functional graphene, 18 parts by weight of Sodium Polyacrylate, polyethylene
18 parts by weight of pyrrolidones, 4 parts by weight of glycerine, 40 weight of 4 parts by weight of medical ethanol, 4 parts by weight of eucalyptus leaf essential oil and high purity water
Part.
Preparation process：
S1 weighs following bulk pharmaceutical chemicals by formula ratio：12 parts by weight of semen litchi, 12 parts by weight of kamuning, 8 parts by weight of Rhizoma Chuanxiong,
8 parts by weight of safflower, 18 parts by weight of the root of Dahurain angelica；
S2, after the bulk pharmaceutical chemicals are pulverized, sieving adds in 6 parts by weight of 8 parts by weight of Peppermint essential oil and lemon,
It is stirred under vacuum, wherein whipping temp is 40 degrees Celsius, and mixing time is 60 hours；
S3, graphene nano material made from graphite powder hydro-thermal method is dried, and 20 parts by weight is weighed according to formula ratio, with S2
In it is brewed after bulk pharmaceutical chemicals be mutually mixed, be placed in Vltrasonic device fully ultrasound 4 hours, after it is ultrasonic uniformly after, by reaction raw materials
Being transferred to can be in heating and stirring device, and heating stirring, wherein heating temperature are 60 degrees Celsius, and mixing time is 90 hours, is obtained
The bulk pharmaceutical chemicals of functional graphene inclusion；
S4, by Macromolecule glue material according to following parts by weight：18 parts by weight of Sodium Polyacrylate, polyvinylpyrrolidone 18
Parts by weight, 4 parts by weight of glycerine are sufficiently mixed stirring 30 minutes, add in 4 parts by weight of medical ethanol, 4 parts by weight of eucalyptus leaf essential oil, vacuum
It is mixed 8 minutes, then adds in high purity water 40 minutes, after being sufficiently mixed uniformly, sealed brewed 6 hours in 60 degrees Celsius,
Secure satisfactory grades sub- material layer；
Polymer material layer in S4 is uniformly applied to the surface of back sheet by S5；
The bulk pharmaceutical chemicals that the functional graphene obtained in S3 includes uniformly are spun on polymer material layer in S5 by S6
Top, then with adherent layer bedding on its surface, you can obtain graphene sustained release headache patch.
Prepare Solution Embodiments 2：
Formula：
It is 10 parts by weight of semen litchi, 10 parts by weight of kamuning, 5 parts by weight of Rhizoma Chuanxiong, 5 parts by weight of safflower, 15 parts by weight of the root of Dahurain angelica, thin
5 parts by weight of lotus essential oil, 5 parts by weight of lemon, 15 parts by weight of functional graphene, 15 parts by weight of Sodium Polyacrylate, polyethylene
15 parts by weight of pyrrolidones, 3 parts by weight of glycerine, 35 weight of 3 parts by weight of medical ethanol, 3 parts by weight of eucalyptus leaf essential oil and high purity water
Part.
Preparation process：
S1 weighs following bulk pharmaceutical chemicals by formula ratio：12 parts by weight of semen litchi, 10 parts by weight of kamuning, 8 parts by weight of Rhizoma Chuanxiong,
8 parts by weight of safflower, 18 parts by weight of the root of Dahurain angelica；
S2, after the bulk pharmaceutical chemicals are pulverized, sieving adds in 6 parts by weight of 8 parts by weight of Peppermint essential oil and lemon,
It is stirred under vacuum, wherein whipping temp is 40 degrees Celsius, and mixing time is 60 hours；
S3, graphene nano material made from graphite powder hydro-thermal method is dried, and 20 parts by weight is weighed according to formula ratio, with S2
In it is brewed after bulk pharmaceutical chemicals be mutually mixed, be placed in Vltrasonic device fully ultrasound 4 hours, after it is ultrasonic uniformly after, by reaction raw materials
Being transferred to can be in heating and stirring device, and heating stirring, wherein heating temperature are 60 degrees Celsius, and mixing time is 90 hours, is obtained
The bulk pharmaceutical chemicals of functional graphene inclusion；
S4, by Macromolecule glue material according to following parts by weight：18 parts by weight of Sodium Polyacrylate, polyvinylpyrrolidone 18
Parts by weight, 4 parts by weight of glycerine are sufficiently mixed stirring 30 minutes, add in 4 parts by weight of medical ethanol, 4 parts by weight of eucalyptus leaf essential oil, vacuum
It is mixed 8 minutes, then adds in high purity water 40 minutes, after being sufficiently mixed uniformly, sealed brewed 6 hours in 60 degrees Celsius,
Secure satisfactory grades sub- material layer；
Polymer material layer in S4 is uniformly applied to the surface of back sheet by S5；
The bulk pharmaceutical chemicals that the functional graphene obtained in S3 includes uniformly are spun on polymer material layer in S5 by S6
Top, then with adherent layer bedding on its surface, you can obtain graphene sustained release headache patch.
Prepare Solution Embodiments 3：
Formula：
15 parts by weight of semen litchi, 15 parts by weight of kamuning, 10 parts by weight of Rhizoma Chuanxiong, 10 parts by weight of safflower, 20 parts by weight of the root of Dahurain angelica,
10 parts by weight of Peppermint essential oil, 10 parts by weight of lemon, 25 parts by weight of functional graphene, 20 parts by weight of Sodium Polyacrylate are gathered
20 parts by weight of vinylpyrrolidone, 5 parts by weight of glycerine, 5 parts by weight of medical ethanol, 5 parts by weight of eucalyptus leaf essential oil and high purity water 45
Parts by weight.
Preparation process：
S1 weighs following bulk pharmaceutical chemicals by formula ratio：12 parts by weight of semen litchi, 15 parts by weight of kamuning, 8 parts by weight of Rhizoma Chuanxiong,
8 parts by weight of safflower, 18 parts by weight of the root of Dahurain angelica；
S2, after the bulk pharmaceutical chemicals are pulverized, sieving adds in 6 parts by weight of 8 parts by weight of Peppermint essential oil and lemon,
It is stirred under vacuum, wherein whipping temp is 40 degrees Celsius, and mixing time is 60 hours；
S3, graphene nano material made from graphite powder hydro-thermal method is dried, and 20 parts by weight is weighed according to formula ratio, with S2
In it is brewed after bulk pharmaceutical chemicals be mutually mixed, be placed in Vltrasonic device fully ultrasound 4 hours, after it is ultrasonic uniformly after, by reaction raw materials
Being transferred to can be in heating and stirring device, and heating stirring, wherein heating temperature are 60 degrees Celsius, and mixing time is 90 hours, is obtained
The bulk pharmaceutical chemicals of functional graphene inclusion；
S4, by Macromolecule glue material according to following parts by weight：18 parts by weight of Sodium Polyacrylate, polyvinylpyrrolidone 18
Parts by weight, 4 parts by weight of glycerine are sufficiently mixed stirring 30 minutes, add in 4 parts by weight of medical ethanol, 4 parts by weight of eucalyptus leaf essential oil, vacuum
It is mixed 8 minutes, then adds in high purity water 40 minutes, after being sufficiently mixed uniformly, sealed brewed 6 hours in 60 degrees Celsius,
Secure satisfactory grades sub- material layer；
Polymer material layer in S4 is uniformly applied to the surface of back sheet by S5；
The bulk pharmaceutical chemicals that the functional graphene obtained in S3 includes uniformly are spun on polymer material layer in S5 by S6
Top, then with adherent layer bedding on its surface, you can obtain graphene sustained release headache patch.
Prepare Solution Embodiments 4：
Formula：
It is 11 parts by weight of semen litchi, 11 parts by weight of kamuning, 6 parts by weight of Rhizoma Chuanxiong, 6 parts by weight of safflower, 16 parts by weight of the root of Dahurain angelica, thin
6 parts by weight of lotus essential oil, 6 parts by weight of lemon, 16 parts by weight of functional graphene, 16 parts by weight of Sodium Polyacrylate, polyethylene
16 parts by weight of pyrrolidones, 3 parts by weight of glycerine, 36 weight of 3 parts by weight of medical ethanol, 3 parts by weight of eucalyptus leaf essential oil and high purity water
Part.
Preparation process：
S1 weighs following bulk pharmaceutical chemicals by formula ratio：12 parts by weight of semen litchi, 11 parts by weight of kamuning, 8 parts by weight of Rhizoma Chuanxiong,
8 parts by weight of safflower, 18 parts by weight of the root of Dahurain angelica；
S2, after the bulk pharmaceutical chemicals are pulverized, sieving adds in 6 parts by weight of 8 parts by weight of Peppermint essential oil and lemon,
It is stirred under vacuum, wherein whipping temp is 40 degrees Celsius, and mixing time is 60 hours；
S3, graphene nano material made from graphite powder hydro-thermal method is dried, and 20 parts by weight is weighed according to formula ratio, with S2
In it is brewed after bulk pharmaceutical chemicals be mutually mixed, be placed in Vltrasonic device fully ultrasound 4 hours, after it is ultrasonic uniformly after, by reaction raw materials
Being transferred to can be in heating and stirring device, and heating stirring, wherein heating temperature are 60 degrees Celsius, and mixing time is 90 hours, is obtained
The bulk pharmaceutical chemicals of functional graphene inclusion；
S4, by Macromolecule glue material according to following parts by weight：18 parts by weight of Sodium Polyacrylate, polyvinylpyrrolidone 18
Parts by weight, 4 parts by weight of glycerine are sufficiently mixed stirring 30 minutes, add in 4 parts by weight of medical ethanol, 4 parts by weight of eucalyptus leaf essential oil, vacuum
It is mixed 8 minutes, then adds in high purity water 40 minutes, after being sufficiently mixed uniformly, sealed brewed 6 hours in 60 degrees Celsius,
Secure satisfactory grades sub- material layer；
Polymer material layer in S4 is uniformly applied to the surface of back sheet by S5；
The bulk pharmaceutical chemicals that the functional graphene obtained in S3 includes uniformly are spun on polymer material layer in S5 by S6
Top, then with adherent layer bedding on its surface, you can obtain graphene sustained release headache patch.
Test example 1：
Sustained release headache patch that Solution Embodiments 1-4 is prepared is prepared as subjects with the present invention, application method is：
The headache position of patient is attached to, replaces within every 24 hours primary new sustained release headache note.
For each headache patch that table 1 shows, 100 patients are chosen, wherein, male patient 50, female patient
50, age distribution section is 30-80 Sui, and treatment time and treatment are as shown in table 1：
Table 1：Test example
Wherein, healing refers to：After treatment, symptom and objective determination are shown, conditions disappear, and restore labour energy completely
Power, and be observed continuously 36 months or more, it no longer recurs, laboratory examination indices meet criterion of cure.
It is effective to refer to：After treatment, cardinal symptom is clearly better, and symptom phenomenon is substantially reduced, and is observed continuously 24 months
Not developing deeply, laboratory examination indices meet criterion of cure.
Refer in vain：After treatment, after cardinal symptom and objective determination, symptom phenomenon is without improvement and rapid deterioration person.
Such as：
Zhang, man, 36 years old, migraine, uninterrupted breaking-out for a long time, drug paste two invalid through hospital diagnosis treatment
It is cured after the course for the treatment of.
Mr. Li, female, 48 years old, acute headache was cured after two courses for the treatment of of the drug paste.
Sun, man, 66 years old, drug dependence headache, in the past few years treatment had no effect, fully recovers after 3 courses for the treatment of of the drug paste.
Test example 2
The experiment effect of sustained release headache note that this test example is wrapped up for investigation without functional graphene.
Formula and other technological parameters are identical with 1 technological parameter of preparation method embodiment, only change the preparation step of S3
Suddenly, specially：
Formula：
It is 12 parts by weight of semen litchi, 12 parts by weight of kamuning, 8 parts by weight of Rhizoma Chuanxiong, 8 parts by weight of safflower, 18 parts by weight of the root of Dahurain angelica, thin
8 parts by weight of lotus essential oil, 6 parts by weight of lemon, 20 parts by weight of functional graphene, 18 parts by weight of Sodium Polyacrylate, polyethylene
18 parts by weight of pyrrolidones, 4 parts by weight of glycerine, 40 weight of 4 parts by weight of medical ethanol, 4 parts by weight of eucalyptus leaf essential oil and high purity water
Part.
Preparation process：
S1 weighs following bulk pharmaceutical chemicals by formula ratio：12 parts by weight of semen litchi, 12 parts by weight of kamuning, 8 parts by weight of Rhizoma Chuanxiong,
8 parts by weight of safflower, 18 parts by weight of the root of Dahurain angelica；
S2, after the bulk pharmaceutical chemicals are pulverized, sieving adds in 6 parts by weight of 8 parts by weight of Peppermint essential oil and lemon,
It is stirred under vacuum, wherein whipping temp is 40 degrees Celsius, and mixing time is 60 hours；
The bulk pharmaceutical chemicals that S2 is obtained are placed in Vltrasonic device abundant ultrasound 4 hours by S3, will reaction original after ultrasound is uniform
Material is transferred to can be in heating and stirring device, and heating stirring, wherein heating temperature are 60 degrees Celsius, and mixing time is 90 hours, is obtained
To common bulk pharmaceutical chemicals；
S4, by Macromolecule glue material according to following parts by weight：18 parts by weight of Sodium Polyacrylate, polyvinylpyrrolidone 18
Parts by weight, 4 parts by weight of glycerine are sufficiently mixed stirring 30 minutes, add in 4 parts by weight of medical ethanol, 4 parts by weight of eucalyptus leaf essential oil, vacuum
It is mixed 8 minutes, then adds in high purity water 40 minutes, after being sufficiently mixed uniformly, sealed brewed 6 hours in 60 degrees Celsius,
Secure satisfactory grades sub- material layer；
Polymer material layer in S4 is uniformly applied to the surface of back sheet by S5；
The bulk pharmaceutical chemicals that the functional graphene obtained in S3 includes uniformly are spun on polymer material layer in S5 by S6
Top, then with adherent layer bedding on its surface, you can the common sustained release for obtaining wrapping up without functional graphene, which is had a headache, to be pasted.
For subjects, application method is the sustained release headache patch being prepared with above-mentioned preparation scheme：It is attached to patient's
Primary new sustained release headache note is replaced at headache position for every 2 days.
For each sustained release headache patch that table 2 shows, 100 patients are chosen, wherein, male patient 50, women
Patient 50, age distribution section are 25-80 Sui, and treatment time and treatment are as shown in table 2：
Table 2：Test example
Wherein, healing refers to：After treatment, symptom and objective determination are shown, conditions disappear, and restore labour energy completely
Power, and be observed continuously 36 months or more, it no longer recurs, laboratory examination indices meet criterion of cure.
It is effective to refer to：After treatment, cardinal symptom is clearly better, and symptom phenomenon is substantially reduced, and is observed continuously 24 months
Not developing deeply, laboratory examination indices meet criterion of cure.
Refer in vain：After treatment, after cardinal symptom and objective determination, symptom phenomenon is without improvement and rapid deterioration person
Basic principle, main feature and the advantages of the present invention of the present invention has been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and what is described in the above embodiment and the description is only the present invention
Principle, various changes and improvements may be made to the invention without departing from the spirit and scope of the present invention, these variation and
Improvement is both fallen in the range of claimed invention.The present invention claims protection domain by appended claims and its
Equivalent defines.
Claims (8)
1. a kind of graphene sustained release headache patch, including back sheet, drug effect layer and adherent layer, the drug effect is placed on the upper of back sheet
Side, the anti-sticking lower section for being placed on back sheet are the bulk pharmaceutical chemicals that treatment is had a headache in the centre position of drug effect layer, it is characterised in that：Institute
Semen litchi, kamuning, Rhizoma Chuanxiong, safflower, the root of Dahurain angelica, Peppermint essential oil and lemon that bulk pharmaceutical chemicals include hot promoting blood circulation and stopping pain of dispelling are stated,
The outer surface of the bulk pharmaceutical chemicals is included by functional grapheme material, to prevent medicine group from gathering, improve the dissolubility of drug.
2. graphene sustained release headache patch according to claim 1, it is characterised in that：The upper surface of the drug effect layer is also laid with
Have a Macromolecule glue-line, used by Macromolecule glue-line material be Sodium Polyacrylate, it is polyvinylpyrrolidone, glycerine, medical
Ethyl alcohol, eucalyptus leaf essential oil and high purity water.
3. graphene sustained release headache patch according to claim 2, it is characterised in that：The bulk pharmaceutical chemicals include following weight
Part：Semen litchi 10-15 parts by weight, kamuning 10-15 parts by weight, Rhizoma Chuanxiong 5-10 parts by weight, safflower 5-10 parts by weight, root of Dahurain angelica 15-
20 parts by weight, Peppermint essential oil 5-10 parts by weight, lemon 5-10 parts by weight, functional graphene 15-25 parts by weight, the height
Material in molecular gel layer includes following parts by weight：Sodium Polyacrylate 15-20 parts by weight, polyvinylpyrrolidone 15-20 weights
Measure part, glycerine 3-5 parts by weight, medical ethanol 3-5 parts by weight, eucalyptus leaf essential oil 3-5 parts by weight and high purity water 35-45 parts by weight.
4. graphene sustained release headache patch according to claim 2, it is characterised in that：The bulk pharmaceutical chemicals include following weight
Part：12 parts by weight of semen litchi, 12 parts by weight of kamuning, 8 parts by weight of Rhizoma Chuanxiong, 8 parts by weight of safflower, 18 parts by weight of the root of Dahurain angelica, peppermint essence
Oily 8 parts by weight, 6 parts by weight of lemon, 20 parts by weight of functional graphene, the material in the Macromolecule glue-line include with
Lower parts by weight：18 parts by weight of Sodium Polyacrylate, 18 parts by weight of polyvinylpyrrolidone, 4 parts by weight of glycerine, 4 weight of medical ethanol
Part, 40 parts by weight of 4 parts by weight of eucalyptus leaf essential oil and high purity water.
5. according to any graphene sustained release headache patches of claim 1-4, it is characterised in that：The functionality graphene packet
The average grain diameter of the bulk pharmaceutical chemicals of conjunction is 115-125 nanometers.
6. a kind of production method of graphene sustained release headache patch, it is characterised in that：Include the following steps：
S1 weighs following bulk pharmaceutical chemicals by formula ratio：12 parts by weight of semen litchi, 12 parts by weight of kamuning, 8 parts by weight of Rhizoma Chuanxiong, safflower 8
Parts by weight, 18 parts by weight of the root of Dahurain angelica；
S2, after the bulk pharmaceutical chemicals are pulverized, sieving adds in 6 parts by weight of 8 parts by weight of Peppermint essential oil and lemon, vacuum
Stirring, wherein whipping temp are 30-50 degrees Celsius, and mixing time is 48-72 hours；
S3, graphene nano material made from graphite powder hydro-thermal method is dried, and 20 parts by weight is weighed according to formula ratio, with being steeped in S2
Bulk pharmaceutical chemicals after system are mutually mixed, and are placed in Vltrasonic device abundant ultrasound 3-5 hours, and after ultrasound is uniform, reaction raw materials are turned
Moving to can be in heating and stirring device, and heating stirring, wherein heating temperature are 50-70 degrees Celsius, and mixing time is 72-108 hours,
Obtain the bulk pharmaceutical chemicals of functional graphene inclusion；
S4, by Macromolecule glue material according to following parts by weight：18 parts by weight of Sodium Polyacrylate, 18 weight of polyvinylpyrrolidone
Part, 4 parts by weight of glycerine are sufficiently mixed stirring 30 minutes, add in 4 parts by weight of medical ethanol, 4 parts by weight of eucalyptus leaf essential oil, vacuum mixing
Stirring 5-10 minutes, then adds in high purity water 40 minutes, small in the 50-70 degrees Celsius of brewed 5-8 of sealing after being sufficiently mixed uniformly
When, secure satisfactory grades sub- material layer；
Polymer material layer in S4 is uniformly applied to the surface of back sheet by S5；
The bulk pharmaceutical chemicals that the functional graphene obtained in S3 includes uniformly are spun on the upper of polymer material layer in S5 by S6
Side, then with adherent layer bedding on its surface, you can obtain graphene sustained release headache patch.
7. the production method of graphene sustained release headache patch according to claim 6, it is characterised in that：Temperature is stirred in the S2
It is 45 degrees Celsius to spend, and brew time is 60 hours.
8. the production method of graphene sustained release headache patch according to claim 6, it is characterised in that：Bubble is sealed in the S4
Temperature processed is 60 degrees Celsius, and the tanning time is 6 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810152406.XA CN108175796A (en) | 2018-02-14 | 2018-02-14 | A kind of graphene sustained release headache patch and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810152406.XA CN108175796A (en) | 2018-02-14 | 2018-02-14 | A kind of graphene sustained release headache patch and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108175796A true CN108175796A (en) | 2018-06-19 |
Family
ID=62552781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810152406.XA Pending CN108175796A (en) | 2018-02-14 | 2018-02-14 | A kind of graphene sustained release headache patch and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108175796A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688880A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Headache-relieving pad and preparation method thereof |
| CN205924516U (en) * | 2016-05-31 | 2017-02-08 | 吉林大学 | Subsides of multilayer graphite alkene nanometer slowly -releasing medicine |
-
2018
- 2018-02-14 CN CN201810152406.XA patent/CN108175796A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688880A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Headache-relieving pad and preparation method thereof |
| CN205924516U (en) * | 2016-05-31 | 2017-02-08 | 吉林大学 | Subsides of multilayer graphite alkene nanometer slowly -releasing medicine |
Non-Patent Citations (8)
| Title |
|---|
| RENYUN ZHANG等: "Carbon nanomaterials as drug carriers: Real time drug release investigation", 《MATERIALS SCIENCE AND ENGINEERING C》 * |
| 乔赟等: "《新编药性歌括400味（彩图版）》", 28 February 2013, 金盾出版社 * |
| 刘兵等: "《中医官窍疗法》", 31 May 2008, 济南出版社 * |
| 张海燕等: "功能化石墨烯的生物医药应用研究", 《中草药》 * |
| 戴义龙: "《草药验方治百病》", 30 September 2006, 福建科学技术出版社 * |
| 李冈荣: "《汉方中草药对症图典.第3册》", 30 September 2015, 新疆人民卫生出版社 * |
| 汪炜燕: "新型功能化氧化石墨烯药物载体的合成及其性能研究", 《万方》 * |
| 胡郁坤等: "《袖珍中药应用速查手册（插图本）》", 31 December 2012, 湖南科学技术出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103041173B (en) | Traditional Chinese medicine external preparation for curing dermatitis and eczema and preparing method thereof | |
| CN108452151A (en) | A kind of vaginal care gel | |
| CN101062289A (en) | External application medicine combination for treating gout | |
| CN104998153A (en) | Sterilization disinfectant for clinical laboratory and preparation method thereof | |
| CN107050002A (en) | A kind of cannabidiol ointment acted on swelling and pain relieving and preparation method thereof | |
| CN108853287A (en) | Pharmaceutical composition, gel preparation and the application of a kind of anti-human papilloma virus (anti-HPV) and anti-gynaecological imflammation | |
| CN105213941A (en) | A kind of Chinese medicine composition being used for the treatment of infantile diarrhea and preparation method thereof | |
| CN102743663B (en) | Chinese medicinal preparation for treating urinary infection and preparation method thereof | |
| JP5690102B2 (en) | Composition for preventing and treating urological diseases and method for producing the same | |
| CN103263531A (en) | Chinese medicine composition for treating prosopalgia and preparation method thereof | |
| CN105056159A (en) | Medicine for treating parasitic diseases of pigs and preparation method thereof | |
| CN105662996A (en) | Traditional Chinese medicine mask for treating menstruation-associated acne | |
| CN104489265A (en) | Compound feed for treatment of moist fowl pox and preparation method thereof | |
| CN105031408B (en) | A kind of composition improving gout | |
| CN105363021A (en) | Gel for promoting wound healing | |
| CN106728934B (en) | A kind of external use plaster prepared by carrier of high polymer material and preparation method thereof | |
| CN108175796A (en) | A kind of graphene sustained release headache patch and preparation method thereof | |
| CN104225200A (en) | Traditional Chinese medicine for treating fluid retention invading heart-lung type cardiac asthma and preparation method thereof | |
| CN102961633B (en) | A kind of preparation for being used to treat postpartum rheumatism | |
| CN106937991A (en) | It is a kind of to be used to treat decoction medicine of cardiovascular and cerebrovascular disease and preparation method thereof | |
| CN105770074A (en) | Traditional Chinese medicine composition for treating wind-heat common cold and preparation method thereof | |
| CN105311600A (en) | Medical gel having sterilizing and disinfecting functions | |
| Sharma et al. | Formulation and evaluation of herbal gel containing extracts of Albezia lebbeck Linn | |
| CN104922449A (en) | Traditional Chinese medicine disinfection solution and preparation method thereof | |
| CN101879028B (en) | Manufacture method of novel medicine flavor health care pillow |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180619 |