CN104688408B - Medical defervescence plaster used and preparation method thereof - Google Patents
Medical defervescence plaster used and preparation method thereof Download PDFInfo
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- CN104688408B CN104688408B CN201510108257.3A CN201510108257A CN104688408B CN 104688408 B CN104688408 B CN 104688408B CN 201510108257 A CN201510108257 A CN 201510108257A CN 104688408 B CN104688408 B CN 104688408B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
Abstract
Medical defervescence plaster used and preparation method thereof.The invention discloses a kind of medical defervescence plaster used, including the medical defervescence plaster used body being made up of backing layer, gel layer and net barrier film, net barrier film and backing layer lay respectively at the upper and lower of gel layer, and backing layer is made up of PU film.The invention also discloses this medical defervescence plaster used preparation method, dihydroxyaluminum aminoacetate is mixed homogeneously with dispersant and wetting agent stirring, it is added thereto to cross-linking agent, binder, thickening agent, heat discoloration microcapsule, medical ethanol and the purified water of surplus again, Peppermint essential oil, Fructus Citri Limoniae quintessence oil, eucalyptus leaf essential oil is added during above-mentioned material is carried out cross-linked polymeric, the most dispersed polymeric alloy membrane being mixed into containing active component, then coat on adherent layer, make attached preparation, again attached preparation is affixed on PU film, medical defervescence plaster used.PU film is nontoxic, has outside high water resistance and has more splendid poisture-penetrability, and this is medical defervescence plaster used has temperature sensing ink, can be according to the change of medical defervescence plaster used upper color, it is judged that whether the decline of temperature, easy to operate.
Description
Technical field
The present invention relates to a kind of medical defervescence plaster used, further relate to a kind of medical defervescence plaster used preparation method.
Background technology
In daily life, people are frequently encountered the heating that a variety of causes causes, especially fever caused by exogenous pathogens, carry out in time
Physical temperature-lowering is the measure first taked, and the multiplex ethanol of Physical temperature-lowering, at patient back, face, abdominal part, axillary fossa etc. rubbing bath, is used
Single cooling antipyretic effect is simply played in ethanol cooling, it is impossible to is inherently eliminated the cause of disease, can take antipyretic analgesic in addition,
And medicine can bring the biggest toxic and side effects to human body, the especially special population such as anemia of pregnant woman, baby more should not take antibiotics.
Medical defervescence plaster used it belong to Physical temperature-lowering articles for use, be widely used in fever of children fever, pass the summer in a leisurely way and work in hot environment
Etc. situation.But, whether current medical defervescence plaster used backing layer is mainly made up of non-woven fabrics, and bring down a fever for patient and do not have
Show intuitively.
Summary of the invention
The technical issues that need to address of the present invention are to provide a kind of medical defervescence plaster used, can be according to medical defervescence plaster used upper color
Change patient temperature whether decline.
Present invention also offers a kind of medical defervescence plaster used preparation method.
The technical solution used in the present invention is: medical defervescence plaster used, and including medical defervescence plaster used body, described medical bringing down a fever loses money in a business
Body is made up of backing layer, gel layer and net barrier film, and described net barrier film is positioned at the upper strata of gel layer, and described backing layer is positioned at gel layer
Lower floor, described gel layer is Macromolecule glue-line, and described Macromolecule glue-line is by the raw material of following mass percent and joins
Ratio is made:
Macromolecule glue material 30-32%；
Dihydroxyaluminum aminoacetate 0.08-0.1%；
Mass concentration is the medical ethanol 1%-2% of 75%；
Peppermint essential oil 1%-2%；
Fructus Citri Limoniae quintessence oil 1%-1.5%；
Eucalyptus leaf essential oil 1%-1.5%；
Heat discoloration microcapsule 0.3%-0.5%；
Purified water adds to 100%；
Wherein, described Macromolecule glue material includes dispersant, wetting agent, thickening agent, binder and cross-linking agent, described point
Powder is sodium polyacrylate, and described wetting agent is glycerol, and described thickening agent is tartaric acid, and described binder is polyvinylpyrrolidine
Ketone, described cross-linking agent is polyvinylpolypyrrolidone.
Described backing layer is made up of PU film.
Above-mentioned medical defervescence plaster used preparation method, comprises the following steps: by dihydroxyaluminum aminoacetate and the high-molecular gel of 0.08-0.1%
In material, mass percent is dispersant and the wetting agent mix homogeneously stirring 20min of 23%-24% of 0.42-0.5%, then to it
Middle addition mass percent is 0.08-0.1% cross-linking agent, 4.5%-5.0% binder, 2%-2.4% thickening agent, 0.3%-0.5% temperature-sensitive
Variable color microcapsule, 1%-2% mass concentration are medical ethanol and the purified water of surplus of 75%, are cross-linked by the material of above-mentioned mixing
Polymerization, vacuum stirring 5-8 min, adding mass percent during cross-linking polymerization is the Peppermint essential oil of 1%-2%, 1%-
The Fructus Citri Limoniae quintessence oil of 1.5%, the eucalyptus leaf essential oil of 1%-1.5%, vacuum stirring 5 minutes in blender, last above-mentioned material is dispersed
It is mixed into the polymeric alloy membrane containing active component, polymeric alloy membrane is coated on adherent layer, make attached preparation, then
Attached preparation is affixed on PU film, medical defervescence plaster used.
In above-mentioned preparation method, described Macromolecule glue material includes dispersant, wetting agent, thickening agent, binder and friendship
Connection agent, described dispersant is sodium polyacrylate, and described wetting agent is glycerol, and described thickening agent is tartaric acid, and described binder is
Polyvinylpyrrolidone, described cross-linking agent is polyvinylpolypyrrolidone.
The invention have the advantage that PU film is a kind of nontoxic environment-friendly materials, its elasticity is good, the highest, has high anti-
Aqueous can have more outward splendid poisture-penetrability (human body antiperspirant gas can between thin film free penetrating), to human body skin without any wound
Evil.Use microcapsule technology be applied to medical defervescence plaster used then for filmogen by heat discoloration powder lock, temperature is more than 38 degrees Celsius
It is automatically releasable by energy conversion, colloid variable color, absorbs head heat so that sufferer hypothermia.This is medical defervescence plaster used has
Temperature sensing ink, can be according to the change of medical defervescence plaster used upper color, it is judged that whether the decline of temperature, easy to operate.
Detailed description of the invention
In order to deepen the understanding of the present invention, below in conjunction with embodiment, the invention will be further described, this embodiment
It is only used for explaining the present invention, is not intended that limiting the scope of the present invention.
Embodiment 1
Medical defervescence plaster used, including medical defervescence plaster used body, described medical defervescence plaster used body by backing layer, gel layer and net every
Film forms, and described net barrier film is positioned at the upper strata of gel layer, and described backing layer is positioned at the lower floor of gel layer, and described gel layer is high score
Sub-gel layer, described Macromolecule glue-line is made up of raw material and the proportioning thereof of following mass percent:
Macromolecule glue material 30%；
Dihydroxyaluminum aminoacetate 0.08%；
Mass concentration is the medical ethanol 1% of 75%；
Peppermint essential oil 1%；
Fructus Citri Limoniae quintessence oil 1%；
Eucalyptus leaf essential oil 1%
Heat discoloration microcapsule 0.3%
Add purified water to 100%.
Wherein, described Macromolecule glue material includes dispersant, wetting agent, thickening agent, binder and cross-linking agent, described point
Powder is sodium polyacrylate, and described wetting agent is glycerol, and described thickening agent is tartaric acid, and described binder is polyvinylpyrrolidine
Ketone.Described cross-linking agent is polyvinylpolypyrrolidone.Described backing layer is made up of PU film.
PU film replaces traditional non-woven fabrics, and non-woven fabrics originally is opaque, and colloid is invisible color, uses PU film
Replacing non-woven fabrics, PU film can be translucent, adds heat discoloration microcapsule in colloid, can see colloid face through PU film
The change of color, can know the situation of change of body temperature intuitively.Because heat discoloration microcapsule comprise stealthy dyestuff, color forming agent and
Temperature control agent, selects to produce the colorant of different temperature range variable colors by different temperature control materials.
Embodiment 2
Medical defervescence plaster used, including medical defervescence plaster used body, described medical defervescence plaster used body by backing layer, gel layer and net every
Film forms, and described net barrier film is positioned at the upper strata of gel layer, and described backing layer is positioned at the lower floor of gel layer, and described gel layer is high score
Sub-gel layer, described Macromolecule glue-line is made up of raw material and the proportioning thereof of following mass percent:
Macromolecule glue material 32%；
Dihydroxyaluminum aminoacetate 0.1%；
Mass concentration is the medical ethanol 2% of 75%；
Peppermint essential oil 2%；
Fructus Citri Limoniae quintessence oil 1.5%；
Eucalyptus leaf essential oil 1.5%
Heat discoloration microcapsule 0.5%
Add purified water to 100%.
Wherein, described Macromolecule glue material includes dispersant, wetting agent, thickening agent, binder and cross-linking agent, described point
Powder is sodium polyacrylate, and described wetting agent is glycerol, and described thickening agent is tartaric acid, and described binder is polyvinylpyrrolidine
Ketone, described cross-linking agent is polyvinylpolypyrrolidone.
Described backing layer is made up of PU film.
Embodiment 3
Medical defervescence plaster used, including medical defervescence plaster used body, described medical defervescence plaster used body by backing layer, gel layer and net every
Film forms, and described net barrier film is positioned at the upper strata of gel layer, and described backing layer is positioned at the lower floor of gel layer, and described gel layer is high score
Sub-gel layer, described Macromolecule glue-line is made up of raw material and the proportioning thereof of following mass percent:
Macromolecule glue material 31%；
Dihydroxyaluminum aminoacetate 0.09%；
Mass concentration is the medical ethanol 1.5% of 75%；
Peppermint essential oil 1.5%；
Fructus Citri Limoniae quintessence oil 1.3%；
Eucalyptus leaf essential oil 1.3%
Heat discoloration microcapsule 0.4%
Add purified water to 100%.
Wherein, described Macromolecule glue material includes dispersant, wetting agent, thickening agent, binder and cross-linking agent, described point
Powder is sodium polyacrylate, and described wetting agent is glycerol, and described thickening agent is tartaric acid, and described binder is polyvinylpyrrolidine
Ketone, described cross-linking agent is polyvinylpolypyrrolidone.
Described backing layer is made up of PU film.
Embodiment 4
A kind of medical defervescence plaster used preparation method, comprises the following steps: the dihydroxyaluminum aminoacetate by 0.08% and Macromolecule glue material
Middle mass percent is dispersant and the wetting agent mix homogeneously stirring 20min of 23% of 0.42%, then is added thereto to quality hundred
Point content be 0.08% cross-linking agent, 4.5% binder, 2% thickening agent, 0.3% heat discoloration microcapsule, 1% mass concentration be the doctor of 75%
By ethanol and the purified water of surplus, the material of above-mentioned mixing being carried out cross-linked polymeric, vacuum stirring 5-8 min, cross-linked polymeric is anti-
Peppermint essential oil that weight/mass percentage composition is 1%, the Fructus Citri Limoniae quintessence oil of 1%, the eucalyptus leaf essential oil of 1% is added, in blender during Ying
Vacuum stirring 5 minutes, the dispersed polymeric alloy membrane being mixed into containing active component of last above-mentioned material, by macromolecular sustained
Release material and coat on adherent layer, make attached preparation, more attached preparation is affixed on PU film, medical defervescence plaster used.
In above-mentioned preparation method, described Macromolecule glue material includes dispersant, wetting agent, thickening agent, binder and friendship
Connection agent, described dispersant is sodium polyacrylate, and described wetting agent is glycerol, and described thickening agent is tartaric acid, and described binder is
Polyvinylpyrrolidone, described cross-linking agent is polyvinylpolypyrrolidone.
Embodiment 5
A kind of medical defervescence plaster used preparation method, comprises the following steps: the dihydroxyaluminum aminoacetate by 0.1% and Macromolecule glue material
Middle mass percent is dispersant and the wetting agent mix homogeneously stirring 20min of 24% of 0.5%, then is added thereto to percent mass
Content be 0.1% cross-linking agent, 5% binder, 2.4% thickening agent, 0.5% heat discoloration microcapsule, 2% mass concentration be the medical second of 75%
Alcohol and the purified water of surplus, carry out cross-linked polymeric, vacuum stirring 5-8 min, cross-linking polymerization mistake by the material of above-mentioned mixing
Journey adds Peppermint essential oil that weight/mass percentage composition is 2%, the Fructus Citri Limoniae quintessence oil of 1.5%, the eucalyptus leaf essential oil of 1.5%, in blender
Vacuum stirring 5 minutes, the dispersed polymeric alloy membrane being mixed into containing active component of last above-mentioned material, by macromolecular sustained
Release material and coat on adherent layer, make attached preparation, more attached preparation is affixed on PU film, medical defervescence plaster used.
In above-mentioned preparation method, described Macromolecule glue material includes dispersant, wetting agent, thickening agent, binder and friendship
Connection agent, described dispersant is sodium polyacrylate, and described wetting agent is glycerol, and described thickening agent is tartaric acid, and described binder is
Polyvinylpyrrolidone, described cross-linking agent is polyvinylpolypyrrolidone.
Embodiment 6
A kind of medical defervescence plaster used preparation method, comprises the following steps: the dihydroxyaluminum aminoacetate by 0.09% and Macromolecule glue material
Middle mass percent is dispersant and the wetting agent mix homogeneously stirring 20min of 24% of 0.45%, then is added thereto to quality hundred
Point content be 0.09% cross-linking agent, 4.8% binder, 2.3% thickening agent, 0.4% heat discoloration microcapsule, 1.5% mass concentration be 75%
Medical ethanol and the purified water of surplus, the material of above-mentioned mixing is carried out cross-linked polymeric, vacuum stirring 5-8 min, crosslinking is poly-
Close in course of reaction and add Peppermint essential oil that weight/mass percentage composition is 1.5%, the Fructus Citri Limoniae quintessence oil of 1.3%, the eucalyptus leaf essential oil of 1.3%,
Vacuum stirring 5 minutes in blender, the dispersed polymeric alloy membrane being mixed into containing active component of last above-mentioned material,
Polymeric alloy membrane is coated on adherent layer, makes attached preparation, more attached preparation is affixed on PU film, medical bring down a fever
Patch.
In above-mentioned preparation method, described Macromolecule glue material includes dispersant, wetting agent, thickening agent, binder and friendship
Connection agent, described dispersant is sodium polyacrylate, and described wetting agent is glycerol, and described thickening agent is tartaric acid, and described binder is
Polyvinylpyrrolidone, described cross-linking agent is polyvinylpolypyrrolidone.
Claims (1)
1. a medical defervescence plaster used preparation method, it is characterised in that described medical defervescence plaster used include medical defervescence plaster used body, institute
Stating medical defervescence plaster used body to be made up of PU film backing layer, gel layer and net barrier film, described net barrier film is positioned at the upper strata of gel layer,
Described backing layer is positioned at the lower floor of gel layer, and described gel layer is Macromolecule glue-line, and described Macromolecule glue-line is by following matter
Raw material and the proportioning thereof of amount percentage ratio are made: 30-32% Macromolecule glue material, 0.08-0.1% dihydroxyaluminum aminoacetate, 1%-2% mass concentration
It is the medical ethanol of 75%, 1%-2% Peppermint essential oil, 1%-1.5% Fructus Citri Limoniae quintessence oil, 1%-1.5% eucalyptus leaf essential oil, 0.3%-0.5% temperature-sensitive
Variable color microcapsule, adds purified water to 100%, and wherein, described Macromolecule glue material includes dispersant, wetting agent, thickening agent, sticks
Agent and cross-linking agent, described dispersant is sodium polyacrylate, and described wetting agent is glycerol, and described thickening agent is tartaric acid, described glutinous
Attached dose is polyvinylpyrrolidone, and described cross-linking agent is polyvinylpolypyrrolidone, and described medical defervescence plaster used preparation method includes following
Step: be the dispersant of 0.42%-0.5% by mass percent in the dihydroxyaluminum aminoacetate of 0.08%-0.1% and Macromolecule glue material
Stir 20min with the wetting agent mix homogeneously of 23%-24%, then to be added thereto to mass percent be 0.08%-0.1% crosslinking
Agent, 4.5%-5.0% binder, 2%-2.4% thickening agent, 0.3%-0.5% heat discoloration microcapsule, 1%-2% mass concentration are 75%
Medical ethanol and the purified water of surplus, the material of above-mentioned mixing is carried out cross-linked polymeric, vacuum stirring 5-8 min, crosslinking is poly-
Closing and adding mass percent in course of reaction is the Peppermint essential oil of 1%-2%, the Fructus Citri Limoniae quintessence oil of 1%-1.5%, 1%-1.5%
Eucalyptus leaf essential oil, vacuum stirring 5 minutes in blender, the dispersed high score being mixed into containing active component of last above-mentioned material
Sub-slow-release material, coats polymeric alloy membrane on net barrier film, makes attached preparation, then is affixed on PU film by attached preparation,
Medical defervescence plaster used.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510108257.3A CN104688408B (en) | 2015-03-12 | 2015-03-12 | Medical defervescence plaster used and preparation method thereof |
| PCT/CN2015/099072 WO2016141755A1 (en) | 2015-03-12 | 2015-12-25 | Medical defervescence patch and preparation method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510108257.3A CN104688408B (en) | 2015-03-12 | 2015-03-12 | Medical defervescence plaster used and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104688408A CN104688408A (en) | 2015-06-10 |
| CN104688408B true CN104688408B (en) | 2016-08-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510108257.3A Active CN104688408B (en) | 2015-03-12 | 2015-03-12 | Medical defervescence plaster used and preparation method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN104688408B (en) |
| WO (1) | WO2016141755A1 (en) |
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| CN104688880A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Headache-relieving pad and preparation method thereof |
| CN104688408B (en) * | 2015-03-12 | 2016-08-31 | 施敬东 | Medical defervescence plaster used and preparation method thereof |
| CN105147443B (en) * | 2015-09-24 | 2017-12-19 | 江门市新时代外用制剂有限公司 | A kind of heat discoloration is defervescence plaster used and preparation method thereof |
| CN105213087A (en) * | 2015-09-24 | 2016-01-06 | 江门市新时代外用制剂有限公司 | One is defervescence plaster used and preparation method thereof |
| CN107647962B (en) * | 2017-09-30 | 2022-05-13 | 浙江三赢新材料有限公司 | Cold and hot compress product with temperature warning function |
| CN108553215A (en) * | 2018-07-03 | 2018-09-21 | 安徽省纳胜化工有限公司 | A kind of Reversible thermochromic of transparent PU Compound Fabrics is defervescence plaster used |
| CN109124862B (en) * | 2018-07-12 | 2020-06-23 | 广州馥邦科技应用有限公司 | Controlled-release long-acting antipyretic patch and preparation method thereof |
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| CN109512802A (en) * | 2018-12-13 | 2019-03-26 | 广州润虹医药科技股份有限公司 | It is a kind of defervescence plaster used and preparation method thereof |
| CN109498255B (en) * | 2018-12-18 | 2020-10-09 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | High-efficient heat transfer type subsides of bringing down a fever |
| CN109662993A (en) * | 2019-01-21 | 2019-04-23 | 日照海旭医疗器械有限公司 | It is medical defervescence plaster used and preparation method thereof |
| CN111012764A (en) * | 2019-12-24 | 2020-04-17 | 广州世和生物科技有限公司 | Testis cooling patch and preparation method thereof |
| CN111450048B (en) * | 2020-04-19 | 2023-12-22 | 广州市雨纯生物科技有限公司 | Gel for antipyretic patch and preparation method thereof |
| CN111588541B (en) * | 2020-04-28 | 2022-06-21 | 浙江理工大学 | Recyclable visual anti-counterfeiting physical cooling paste and preparation method thereof |
| CN111728858B (en) * | 2020-07-03 | 2023-02-03 | 黄洋世 | Quantum energy magnetic pulse-through type acupoint pressure stimulation patch |
| CN113413451B (en) * | 2021-06-30 | 2022-11-01 | 贵州大学 | Evodia rutaecarpa and ginger emplastrum and preparation method thereof |
| CN114732798A (en) * | 2022-03-14 | 2022-07-12 | 珠海国佳新材股份有限公司 | Medical gel patch |
| CN115078456B (en) * | 2022-06-23 | 2023-07-18 | 云南白药集团无锡药业有限公司 | Device and method for detecting antipyretic and cooling capacity of medical antipyretic patch |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2016141755A1 (en) | 2016-09-15 |
| CN104688408A (en) | 2015-06-10 |
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