CN102813934A - Moistureproof film coating agent for traditional Chinese medicine tablets and preparation method thereof - Google Patents
Moistureproof film coating agent for traditional Chinese medicine tablets and preparation method thereof Download PDFInfo
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- CN102813934A CN102813934A CN2012103480196A CN201210348019A CN102813934A CN 102813934 A CN102813934 A CN 102813934A CN 2012103480196 A CN2012103480196 A CN 2012103480196A CN 201210348019 A CN201210348019 A CN 201210348019A CN 102813934 A CN102813934 A CN 102813934A
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Abstract
The invention relates to a moistureproof film coating agent for traditional Chinese medicine tablets and a preparation method thereof. The technical characteristic is that the film coating agent comprises the following components according to mass proportion: 20-50 portions of vinyl pyrrolidone-vinyl acetic ester copolymer, 10-30 portions of 5-15 centipoise hydroxypropyl methylcellulose, 10-20 portions of polyethylene glycol 6000, 1-5 portions of tween 80, 0-25 portions of ferric oxide, 0-20 portions of titanium dioxide and 0.1-30 portions of talc powder. The preparation method comprises the following steps: (1) the vinyl pyrrolidone-vinyl acetic ester copolymer, the 5-15 centipoise hydroxypropyl methylcellulose, the polyethylene glycol 6000, the ferric oxide, the titanium dioxide and the talc powder are put in a high-speed mixer for mixing; and (2) the tween 80 is evenly poured to and mixed with the materials in the high-speed mixer to prepare the finished products of moistureproof film coating agent for traditional Chinese medicine tablets. Various macromolecule film-forming materials are adopted to prepare the film coating agent, thus the moistureproof performance of traditional Chinese medicine tablets is enhanced, the problem of moisture absorption of traditional Chinese medicine is thoroughly resolved and the application range of film coating agent is enlarged.
Description
Technical field
The invention belongs to the excipient substance field, especially a kind of Chinese medicinal tablet moisture-proofing film coating agent and preparation method thereof.
Background technology
Film coating agent is a kind of a kind of material that coats oral tablet; Usually form by film former, plasticizer, auxiliary additive and coloring agent; Be solvent with water or water and alcoholic acid mixed liquor when using; Be sprayed on the medicated core surface and can form bright and clean uniform film-coat, thereby make medicated core avoid the erosion of light, oxygen, moisture, work and beautify outward appearance, improve mouthfeel, hide effects such as abnormal smells from the patient.Film coating agent is compared with sweet tablet, can save the coating operating time, and it is more stable to wrap later tablet performance.Though the film coating agent mechanical performance on the market is all right now, and is unsatisfactory to the Chinese medicinal tablet moisture effect, can not thoroughly solve the sucting wet problem of Chinese medicine.
Summary of the invention
The objective of the invention is to overcome the deficiency of prior art, a kind of reasonable in design, Chinese medicinal tablet moisture-proofing film coating agent that humidity resistance is good and preparation method thereof is provided.
The present invention solves its technical problem and takes following technical scheme to realize:
The agent of a kind of Chinese medicinal tablet moisture-proofing film coating, its mass fraction that constitutes component and component thereof is: 0.1～30 part of vinylpyrrolidone-20～50 parts of vinylacetic acid ester copolymers, 10～30 parts of the hypromelloses of 5-15 centipoise, 10～20 parts of polyethylene glycol 6000s, 1～5 part of Tween 80,0～25 part of ferrum oxide, 0～20 part of white titanium pigment and Pulvis Talci.
And the mass ratio of the hypromellose of said vinylpyrrolidone-vinylacetic acid ester copolymer and 5-15 centipoise is 1:1.
The method for preparing of a kind of Chinese medicinal tablet moisture-proofing film coating agent may further comprise the steps:
⑴ throw into hypromellose, polyethylene glycol 6000, ferrum oxide, white titanium pigment and the Pulvis Talci of vinylpyrrolidone-vinylacetic acid ester copolymer, 5-15 centipoise in the high-speed mixer and mix;
⑵ mix after evenly drench Tween 80 on the material in the high-speed mixer and promptly process Chinese medicinal tablet moisture-proofing film coating agent finished product.
And the rotating speed of said step ⑴ high-speed mixer is 2700 rev/mins, incorporation time 0.5～3 minute.
And the rotating speed of said step ⑵ high-speed mixer is 2700 rev/mins, mixes 5～20 minutes.
Advantage of the present invention and good effect are:
The agent of this Chinese medicinal tablet moisture-proofing film coating adopts multiple macromolecule filming material to be prepared from; Changed the physics film character in the film coating agent prescription; Strengthened the humidity resistance of Chinese medicinal tablet; Thoroughly solved the sucting wet problem of Chinese medicine, enlarged the scope of application of film coating agent, do not need producer more exchange device just can carry out coating production.
The specific embodiment
Below in conjunction with instance the present invention is done and to further describe.
The agent of a kind of Chinese medicinal tablet moisture-proofing film coating, its mass fraction that constitutes component and component thereof is: 0.1～30 part of vinylpyrrolidone-20～50 parts of vinylacetic acid ester copolymers, 10～30 parts of the hypromelloses of 5-15 centipoise, 10～20 parts of polyethylene glycol 6000s, 1～5 part of Tween 80,0～25 part of ferrum oxide, 0～20 part of white titanium pigment and Pulvis Talci.
The method for preparing of a kind of Chinese medicinal tablet moisture-proofing film coating agent, form by following step:
⑴ throw into hypromellose, polyethylene glycol 6000, ferrum oxide, white titanium pigment and the Pulvis Talci of vinylpyrrolidone-vinylacetic acid ester copolymer, 5-15 centipoise in the high-speed mixer, mixed 0.5～3 minute for 2700 rev/mins at rotating speed; The rotating speed of this high-speed mixer is 2700 rev/mins, incorporation time 0.5～3 minute.
⑵ after evenly drench Tween 80 on the material in the high-speed mixer, promptly processed Chinese medicinal tablet moisture-proofing film coating agent finished product in 0.5～3 minute in 2700 rev/mins of mixing of rotating speed.
Embodiment 1
The method for preparing of a kind of Chinese medicinal tablet moisture-proofing film coating agent comprises:
(1) takes by weighing vinylpyrrolidone-20 parts of vinylacetic acid ester copolymers, 30 parts of the hypromelloses of 5-15 centipoise, 20 parts of polyethylene glycol 6000s, 3 parts of Tween 80s, 10 parts of ferrum oxides, 17 parts of Pulvis Talci by ratio of quality and the number of copies;
(2) hypromellose, polyethylene glycol 6000, ferrum oxide, white titanium pigment and the Pulvis Talci of vinylpyrrolidone-vinylacetic acid ester copolymer, 5-15 centipoise are thrown in the high-speed mixer, mixed 2 minutes for 2700 rev/mins at rotating speed;
(3) after evenly drenching Tween 80 on the material in the high-speed mixer, promptly processed the agent of a kind of Chinese medicinal tablet moisture-proofing film coating in 15 minutes in 2700 rev/mins of mixing of rotating speed.
Embodiment 2
(1) takes by weighing 17 parts of vinylpyrrolidone-50 parts of vinylacetic acid ester copolymers, the hypromellose 10 of 5-15 centipoise, 10 parts of polyethylene glycol 6000s, 3 parts of Tween 80s, 10 parts of ferrum oxides and Pulvis Talci by ratio of quality and the number of copies;
(2) hypromellose, polyethylene glycol 6000, ferrum oxide, white titanium pigment and the Pulvis Talci of 5-15 centipoise are thrown in the high-speed mixer, mixed 2 minutes for 2700 rev/mins at rotating speed;
(3) after evenly drenching Tween 80 on the material in the high-speed mixer, promptly processed a kind of Chinese medicinal tablet film coating agent in 15 minutes in 2700 rev/mins of mixing of rotating speed.
Adopt conventional method, solution is processed in a kind of Chinese medicinal tablet moisture-proofing film coating agent of embodiment 1 and embodiment 2, be sprayed on Chinese medicine medicated core surface, process the moisture-proofing film coating sheet.Carry out moisture-resistant test then: adopt climatic chamber that two kinds of thin membrane coated tablets and general thin membrane coated tablet are carried out the experiment of the tablet moisture absorption.Moisture-resistant test mainly is to detect under given conditions, the test of tablet moisture absorption situation in week age.(two kinds of thin membrane coated tablets of precision weighing (6) place surface plate, and temperature constant is 42 ℃, and humidity is constant to be 80 parts, every day same time precision weighing once, the record experimental data.
Mensuration result is following
Embodiment 3
The method for preparing of a kind of Chinese medicinal tablet moisture-proofing film coating agent comprises:
(1) takes by weighing 17 parts of vinylpyrrolidone-40 parts of vinylacetic acid ester copolymers, 20 parts of the hypromelloses of 5-15 centipoise, 10 parts of polyethylene glycol 6000s, 3 parts of Tween 80s, 10 parts of white titanium pigments and Pulvis Talci by ratio of quality and the number of copies;
(2) hypromellose, polyethylene glycol 6000, ferrum oxide, white titanium pigment and the Pulvis Talci of vinylpyrrolidone-vinylacetic acid ester copolymer, 5-15 centipoise are thrown in the high-speed mixer, mixed 3 minutes for 2700 rev/mins at rotating speed;
(3) after evenly drenching Tween 80 on the material in the high-speed mixer, promptly processed the agent of a kind of Chinese medicinal tablet moisture-proofing film coating in 20 minutes in 2700 rev/mins of mixing of rotating speed.
Embodiment 4
The method for preparing of a kind of Chinese medicinal tablet moisture-proofing film coating agent comprises:
(1) takes by weighing 40 parts of vinylpyrrolidones-vinylacetic acid ester copolymer by ratio of quality and the number of copies, 15 parts of 20 parts of polyethylene glycol 6000s, 5 parts of Tween 80s, 20 parts of white titanium pigments and Pulvis Talci;
(2) vinylpyrrolidone-vinylacetic acid ester copolymer, polyethylene glycol 6000, ferrum oxide, white titanium pigment and Pulvis Talci are thrown in the high-speed mixer, mixed 3 minutes for 2700 rev/mins at rotating speed;
(3) after evenly drenching Tween 80 on the material in the high-speed mixer, promptly processed a kind of Chinese medicinal tablet film coating agent in 20 minutes in 2700 rev/mins of mixing of rotating speed.
Mensuration result is following
Embodiment 5
The method for preparing of a kind of Chinese medicinal tablet moisture-proofing film coating agent comprises:
(1) takes by weighing 14 parts of vinylpyrrolidone-35 parts of vinylacetic acid ester copolymers, the hypromellose 15 of 5-15 centipoise, 15 parts of polyethylene glycol 6000s, 1 part of Tween 80,10 parts of ferrum oxides, 10 parts of white titanium pigments and Pulvis Talci by ratio of quality and the number of copies;
(2) hypromellose, polyethylene glycol 6000, ferrum oxide, white titanium pigment and the Pulvis Talci of vinylpyrrolidone-vinylacetic acid ester copolymer, 5-15 centipoise are thrown in the high-speed mixer, mixed 2 minutes for 2700 rev/mins at rotating speed;
(3) after evenly drenching Tween 80 on the material in the high-speed mixer, promptly processed the agent of a kind of Chinese medicinal tablet moisture-proofing film coating in 15 minutes in 2700 rev/mins of mixing of rotating speed.
Mensuration result is following
Comparative sample is the sample of other coating materials manufacturers.
Detect embodiment with climatic chamber and compare, experimental result shows that the moisture effect of this Chinese medicine moisture-proofing film coating agent is remarkable.
It is emphasized that; Embodiment of the present invention is illustrative; Rather than it is determinate; Therefore the present invention is not limited to the embodiment described in the specific embodiment, and every other embodiments that drawn by those skilled in the art's technical scheme according to the present invention belong to the scope that the present invention protects equally.
Claims (5)
1. Chinese medicinal tablet moisture-proofing film coating agent is characterized in that: its mass fraction that constitutes component and component thereof is: 0.1～30 part of vinylpyrrolidone-20～50 parts of vinylacetic acid ester copolymers, 10～30 parts of the hypromelloses of 5-15 centipoise, 10～20 parts of polyethylene glycol 6000s, 1～5 part of Tween 80,0～25 part of ferrum oxide, 0～20 part of white titanium pigment and Pulvis Talci.
2. Chinese medicinal tablet moisture-proofing film coating according to claim 1 agent is characterized in that: the mass ratio of the hypromellose of vinylpyrrolidone-vinylacetic acid ester copolymer and 5-15 centipoise is 1:1.
3. the method for preparing of a Chinese medicinal tablet moisture-proofing film coating agent according to claim 1 or claim 2 is characterized in that: may further comprise the steps:
⑴ throw into hypromellose, polyethylene glycol 6000, ferrum oxide, white titanium pigment and the Pulvis Talci of vinylpyrrolidone-vinylacetic acid ester copolymer, 5-15 centipoise in the high-speed mixer and mix;
⑵ mix after evenly drench Tween 80 on the material in the high-speed mixer and promptly process Chinese medicinal tablet moisture-proofing film coating agent finished product.
4. the method for preparing of Chinese medicinal tablet moisture-proofing film coating according to claim 3 agent is characterized in that: the rotating speed of said step ⑴ high-speed mixer is 2700 rev/mins, incorporation time 0.5～3 minute.
5. the method for preparing of Chinese medicinal tablet moisture-proofing film coating according to claim 3 agent is characterized in that: the rotating speed of said step ⑵ high-speed mixer is 2700 rev/mins, mixes 5～20 minutes.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104587481A (en) * | 2013-10-31 | 2015-05-06 | 刘桐言 | Preparation method of moisture-proof traditional Chinese medicine coated film |
| CN106727401A (en) * | 2016-12-05 | 2017-05-31 | 钦州市钦南区生产力促进中心 | A kind of pharmaceutic adjuvant film coating material and preparation method thereof |
| CN107550883A (en) * | 2017-10-10 | 2018-01-09 | 常州市天宁区鑫发织造有限公司 | A kind of preparation method of damp-proof Chinese medicine sugar-coat |
| CN108676452A (en) * | 2018-07-05 | 2018-10-19 | 安徽思凯瑞环保科技有限公司 | The method of modifying of the thick titanium valve of Deliquescence-resistant |
| CN113615861A (en) * | 2021-07-02 | 2021-11-09 | 恒信伟业科技(东莞)有限公司 | Heating non-burning plant particles with moisture-proof layer and preparation method thereof |
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| CN101085362A (en) * | 2007-06-25 | 2007-12-12 | 天津市普乐新药用辅料有限公司 | Bright thin film coating agent and preparation method |
| CN101120953A (en) * | 2006-08-10 | 2008-02-13 | 上海新菲尔生物制药工程技术有限公司 | Complete water type thin film coating pre-mixture for traditional Chinese medicine tablets |
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2012
- 2012-09-18 CN CN2012103480196A patent/CN102813934B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101120953A (en) * | 2006-08-10 | 2008-02-13 | 上海新菲尔生物制药工程技术有限公司 | Complete water type thin film coating pre-mixture for traditional Chinese medicine tablets |
| CN101085362A (en) * | 2007-06-25 | 2007-12-12 | 天津市普乐新药用辅料有限公司 | Bright thin film coating agent and preparation method |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104587481A (en) * | 2013-10-31 | 2015-05-06 | 刘桐言 | Preparation method of moisture-proof traditional Chinese medicine coated film |
| CN106727401A (en) * | 2016-12-05 | 2017-05-31 | 钦州市钦南区生产力促进中心 | A kind of pharmaceutic adjuvant film coating material and preparation method thereof |
| CN107550883A (en) * | 2017-10-10 | 2018-01-09 | 常州市天宁区鑫发织造有限公司 | A kind of preparation method of damp-proof Chinese medicine sugar-coat |
| CN108676452A (en) * | 2018-07-05 | 2018-10-19 | 安徽思凯瑞环保科技有限公司 | The method of modifying of the thick titanium valve of Deliquescence-resistant |
| CN113615861A (en) * | 2021-07-02 | 2021-11-09 | 恒信伟业科技(东莞)有限公司 | Heating non-burning plant particles with moisture-proof layer and preparation method thereof |
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| CN102813934B (en) | 2013-11-27 |
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