CN107550883A - A kind of preparation method of damp-proof Chinese medicine sugar-coat - Google Patents
A kind of preparation method of damp-proof Chinese medicine sugar-coat Download PDFInfo
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Abstract
The invention discloses a kind of preparation method of damp-proof Chinese medicine sugar-coat, belong to technical field of medicine preparation.The present invention is modified by alkali lye and etherifying agent to ethyl cellulose and diethylamine cellulose acetate,Then the auxiliary material such as plasticizer and stabilizer is added,The film of continuous densification can be formed,Continuously add solvent,Solvent can be such that macromolecule filming material fully dissolves,Shellac is modified finally by urea,By itself and vegetable oil and biogas slurry blending fermentation,Plant oil decomposition is produced into lipophile ester group using microorganism,And ester group is caused to be grafted to part self-control sugar-coat material surface under the self-crosslinking of microorganism,And the introducing of hydrophobicity ester group,Wherein add stickum,Improve caking ability of the shellac to self-control sugar coating material,So as to reduce the hygroscopic capacity of Chinese medicine preparation,Be advantageous to the production and storage of Chinese medicine preparation,And quality can be improved,The application of the technology will further extend,The development of pharmaceutical preparations technology also will be greatly promoted simultaneously.
Description
Technical field
The invention discloses a kind of preparation method of damp-proof Chinese medicine sugar-coat, belong to technical field of medicine preparation.
Background technology
Sugar-coat refers to coating tablet of the clothing layer based on sucrose, is to apply earliest, widest coating tablet main Types.With high score
Sub- material claims Film coated tablets for the coating tablet of tablet clothing film.Typical thin films clothing material mainly has following kind:1. hydroxypropyl methyl
Cellulose(HPMC);2. hydroxypropyl cellulose(HPC);3. Eudragit Ⅳ;4. styrene-ethylene pyridine copolymer;⑤
Polyvinylpyrrolidone.
Sugar-coat includes following aspect:Separation layer:Fluid-tight separation layer is wrapped in plain piece first, to prevent the bag below
Moisture soaks people's label during clothing.Sub-coat:To eliminate the corner angle of tablet, two layers thicker of powder clothing is wrapped outside separation layer
Layer, main material is syrup, talcum powder.Sugarcoating layer:Make it is unilateral smooth, it is fine and smooth solid, generally wrap 10~15 layers.There is sugar colour
Clothing layer:The technique that color sugarcoating layer is surrounded by with above-mentioned sugar coating layer is identical, and food moon pigment, main mesh are simply with the addition of in syrup
Be for the ease of identification with it is attractive in appearance.Typically about need to pack 8~15 layers.Polishing:Its purpose is to increase tablet gloss and
The hydrophobicity on surface.
In daily life, all can a bag glace outside medicine.It is common formulations that Chinese medicine, which wards off garment piece, the sugar outside Chinese patent drug
Clothing is act as:Can aesthetic appeal;Smell is covered, avoids special odor such as stink, bitter taste etc. of Chinese medicine;And to gastral thorn
Swash;It is easy to oral, powdery type medicine bag sugar-coat is conveniently taken;Prevent from going mouldy, extend the preservation validity period of tablet.It is to make medicine
With air exclusion, the deliquescence or chemical change of medicine are avoided, the volatilization of medicine is prevented and influences the accurate of dosage;It is by sugar-coat
Color help identify medicine.
Therefore, invent a kind of damp-proof Chinese medicine sugar-coat has positive effect to technical field of medicine preparation.
The content of the invention
The technical problems to be solved by the invention:There is the shortcomings that easy moisture absorption for current sugar-coat, there is provided Yi Zhongfang
The preparation method of tidal stencils Chinese medicine sugar-coat.
In order to solve the above technical problems, the present invention uses technical scheme as described below:
A kind of preparation method of damp-proof Chinese medicine sugar-coat, it is characterised in that specifically preparation process is:
(1)By ethyl cellulose and diethylamine cellulose acetate mixed grinding, cellulose powder is obtained, is added into cellulose powder
Enter the mixing of 80~100mL sodium hydroxide solutions, 10~12mL3- chloro-2-hydroxypropyl-trimethyl ammonium chlorides added after stirring,
After continuing hybrid reaction, it is put into baking oven and dries, as make modified cellulose by oneself;
(2)200 mesh sieves are crossed after weighing 80~110g self-control modified celluloses and 10~12g talcum powder mixed grindings again, were collected
Powder is sieved, 12~20mL polyethylene glycol is sequentially added into sieving powder and 8~12mL ATBCs mix, then is put
Enter in baking oven and dry, as make sugar coating material by oneself, it is standby;
(3)Shellac and urea Hybrid Heating are stirred, obtain mixture, after it is cooled to room temperature, is added into mixture mixed
The beet oil of compound quality 5% and the biogas slurry of mixture quality 0.6%, are fitted into fermentation tank, are sealed by fermentation, after fermentation ends, take
Go out tunning, as Modified Shell-lac for Cuprous Surface Anticorrosion;
(4)Continue to weigh 20~40g cornstarch to pour into the beaker containing 80~100mL deionized waters and mix, obtain
Cornstarch suspension, cornstarch suspension and absolute ethyl alcohol are mixed, filter to obtain solids again after stirring, continued
Solids is ground, obtains modified starch;
(5)Count in parts by weight, weigh self-control sugar coating material, Modified Shell-lac for Cuprous Surface Anticorrosion, modified starch and deionized water respectively and mix,
Mixing suspension is obtained, then adds peach gum, sucrose and silica gel into mixing suspension and is placed in stirrer for mixing stirring, is dried out
Material, as make sugar-coat solid by oneself;
(6)Self-control sugar-coat solid is added in deionized water and mixed, sugar-coat solid suspension is obtained, in be coated
Medicine solid is added in coating pan, starts coating pan, hot blast is blown into coating pan, and Chinese medicine solid to be coated is preheated, then
Sugar-coat solid suspension is sprayed onto on Chinese medicine solid to be coated, Cotton seeds, discharged, you can damp-proof Chinese medicine sugar-coat is made.
Step(1)Described in ethyl cellulose and diethylamine cellulose acetate mass ratio be 1:1, milling time 8
~10min, the mass fraction of sodium hydroxide solution is 8%, and mixing time is 10~16min, and reaction temperature is 30~50 DEG C, instead
It is 8~10min between seasonable, drying temperature is 45~65 DEG C, and drying time is 1~2h.
Step(2)Described in mixing time be 3~5min, drying temperature is 65~85 DEG C, and drying time is 1~2h.
Step(3)Described in shellac and urea mass ratio be 3:1, whipping temp is 140~160 DEG C, mixing time
For 30~50min, fermentation temperature is 35~45 DEG C, and fermentation time is 6~8 days.
Step(4)Described in mixing time be 10~12min, the volume ratio of cornstarch suspension and absolute ethyl alcohol is
4:1, mixing time is 10~15min.
Step(5)Described in meter in parts by weight, weigh respectively 30~50 parts self-control sugar coating material, 6~8 parts of modified worms
Glue, 3~5 portions of modified starches, 10~12 parts of deionized waters, 2~4 parts of peach gums, 1~3 portion of sucrose and 2~4 parts of silica gel, mixing time
For 8~12min, whipping temp is that mixing time is 1~2h at 30~50 DEG C.
Step(6)Described in mixing time be 45~60min, preheating temperature is 30~40 DEG C, processing time is 1~
2h。
Compared with other method, advantageous effects are the present invention:
The present invention is modified by alkali lye and etherifying agent to ethyl cellulose and diethylamine cellulose acetate, wherein ethyl cellulose
Element and diethylamine cellulose acetate are all in itself hydrophobic film-forming materials, improve the humidity resistance of Chinese medicine sugar-coat, then add
The auxiliary material such as plasticizer and stabilizer, the film of continuous densification can be formed, so as to reach moisture effect, improve Chinese medicine sugar again
The humidity resistance of clothing, solvent is continuously added, solvent can be such that macromolecule filming material fully dissolves, and strand is fully extended, and is had
Good rush film forming and effumability, and it is nontoxic, cost is low, further reach moisture effect, finally by urea to worm
Glue is modified, and by itself and vegetable oil and biogas slurry blending fermentation, plant oil decomposition is produced into lipophile ester group using microorganism,
And cause ester group to be grafted to part self-control sugar-coat material surface under the self-crosslinking of microorganism, enhance sugar coating material and worm
The compatibility of glue and high polymer, and the introducing of hydrophobicity ester group, the water resistance of sugar coating material is improved again, wherein adding
Enter stickum, caking ability of the shellac to self-control sugar coating material is improved, so as to reduce the hygroscopic capacity of Chinese medicine preparation, in being advantageous to
The production and storage of medicine preparation, and quality can be improved, the application of the technology will further extend, while also will greatly push away
The development of dynamic pharmaceutical preparations technology.
Embodiment
It is 1 in mass ratio:1 by ethyl cellulose and diethylamine cellulose acetate 8~10min of mixed grinding, obtains fiber
Plain powder, the sodium hydroxide solution mixing 10 that 80~100mL of addition mass fractions are 8% into cellulose powder~
16min, after stirring add 10~12mL3- chloro-2-hydroxypropyl-trimethyl ammonium chlorides, at 30~50 DEG C continue hybrid reaction 8~
After 10min, it is put into baking oven, 1~2h is dried at 45~65 DEG C, as makes modified cellulose by oneself, then weighs 80~110g certainly
200 mesh sieves are crossed after modified cellulose and 10~12g talcum powder mixed grinding processed, collect sieving powder, into sieving powder successively
Add 12~20mL polyethylene glycol and 8~12mL ATBCs mix 3~5min, place into baking oven 65~85
1~2h is dried at DEG C, as makes sugar coating material by oneself, it is standby, it is in mass ratio 3:1 mixes shellac and urea, 140~160
30~50min of heating stirring at DEG C, obtains mixture, and after it is cooled to room temperature, mixture quality 5% is added into mixture
Beet oil and mixture quality 0.6% biogas slurry, is fitted into fermentation tank, is sealed by fermentation 6~8 days at 35~45 DEG C, ferment tie
Shu Hou, takes out tunning, as Modified Shell-lac for Cuprous Surface Anticorrosion, continues to weigh 20~40g cornstarch and pours into containing 80~100mL deionizations
10~12min is mixed in the beaker of water, cornstarch suspension is obtained, is by volume 4:1 by cornstarch suspension
10~15min is mixed with absolute ethyl alcohol, filters to obtain solids again after stirring, continues solids grinding 8~10min,
Obtain modified starch, count in parts by weight, weigh respectively 30~50 parts self-control sugar coating materials, 6~8 parts of Modified Shell-lac for Cuprous Surface Anticorrosion, 3~5 parts
Modified starch and 10~12 parts of deionized waters mix 8~12min, obtain mixing suspension, then add into mixing suspension
Enter 2~4 parts of peach gums, 1~3 portion of sucrose and 2~4 parts of silica gel to be placed in mixer, 1~2h is mixed at 30~50 DEG C, do
Dry discharging, as make sugar-coat solid by oneself, self-control sugar-coat solid is added in deionized water, 45~60min is mixed, obtains
Sugar-coat solid suspension, Chinese medicine solid to be coated is added in coating pan, starts coating pan, heat is blown into coating pan
Wind, Chinese medicine solid to be coated is preheated to 30~40 DEG C, then sugar-coat solid suspension is sprayed onto on Chinese medicine solid to be coated,
1~2h of Cotton seeds, discharging, you can damp-proof Chinese medicine sugar-coat is made.
Example 1
It is 1 in mass ratio:1 by ethyl cellulose and diethylamine cellulose acetate mixed grinding 8min, obtains cellulose powder, to
The sodium hydroxide solution that 80mL mass fractions are 8% is added in cellulose powder and mixes 10min, 10mL3- is added after stirring
Chloro-2-hydroxypropyl-trimethyl ammonium chloride, after continuing hybrid reaction 8min at 30 DEG C, it is put into baking oven, 1h is dried at 45 DEG C,
As make modified cellulose by oneself, then 200 mesh sieves are crossed after weighing 80g self-control modified celluloses and 10g talcum powder mixed grindings, collect
Sieved powder, and 12mL polyethylene glycol is sequentially added into sieving powder and 8mL ATBCs mix 3min, is placed into
1h is dried in baking oven at 65 DEG C, as makes sugar coating material by oneself, it is standby, it is in mass ratio 3:1 mixes shellac and urea,
Heating stirring 30min, obtains mixture at 140 DEG C, and after it is cooled to room temperature, mixture quality 5% is added into mixture
The biogas slurry of beet oil and mixture quality 0.6%, is fitted into fermentation tank, is sealed by fermentation 6 days at 35 DEG C, after fermentation ends, takes out
Tunning, as Modified Shell-lac for Cuprous Surface Anticorrosion, continue to weigh 20g cornstarch to pour into the beaker containing 80mL deionized waters mixing
10min, cornstarch suspension is obtained, be by volume 4:1 mixes cornstarch suspension and absolute ethyl alcohol
10min, filter to obtain solids again after stirring, continue solids grinding 8min, obtain modified starch, count in parts by weight,
30 parts of self-control sugar coating materials, 6 parts of Modified Shell-lac for Cuprous Surface Anticorrosion, 3 portions of modified starches and 10 parts of deionized waters are weighed respectively and mix 8min, are obtained
To mixing suspension, then add 2 parts of peach gums, 1 portion of sucrose and 2 parts of silica gel into mixing suspension and be placed in mixer, at 30 DEG C
Lower mixing 1h, discharging is dried, as make sugar-coat solid by oneself, self-control sugar-coat solid is added in deionized water, mixing is stirred
45min is mixed, obtains sugar-coat solid suspension, Chinese medicine solid to be coated is added in coating pan, starts coating pan, to coating
Hot blast is blown into pot, Chinese medicine solid to be coated is preheated to 30 DEG C, then sugar-coat solid suspension is sprayed onto to Chinese medicine to be coated
On solid, Cotton seeds 1h, discharging, you can damp-proof Chinese medicine sugar-coat is made.
Example 2
It is 1 in mass ratio:1 by ethyl cellulose and diethylamine cellulose acetate mixed grinding 9min, obtains cellulose powder, to
The sodium hydroxide solution that 90mL mass fractions are 8% is added in cellulose powder and mixes 13min, 11mL3- is added after stirring
Chloro-2-hydroxypropyl-trimethyl ammonium chloride, after continuing hybrid reaction 9min at 40 DEG C, it is put into baking oven, is dried at 55 DEG C
1.5h, as make modified cellulose by oneself, then 200 mesh are crossed after weighing 100g self-control modified celluloses and 11g talcum powder mixed grindings
Sieve, sieving powder is collected, 15mL polyethylene glycol is sequentially added into sieving powder and 10mL ATBCs mix
4min, place into and dry 1.5h in baking oven at 75 DEG C, as make sugar coating material by oneself, it is standby, it is in mass ratio 3:1 by shellac and
Urea mixes, and heating stirring 40min, obtains mixture at 150 DEG C, after it is cooled to room temperature, is added into mixture mixed
The beet oil of compound quality 5% and the biogas slurry of mixture quality 0.6%, are fitted into fermentation tank, are sealed by fermentation 7 days at 40 DEG C, sent out
After ferment terminates, tunning is taken out, as Modified Shell-lac for Cuprous Surface Anticorrosion, continue to weigh 30g cornstarch and pour into containing 90mL deionized waters
11min is mixed in beaker, obtains cornstarch suspension, is by volume 4:1 by cornstarch suspension and anhydrous second
Alcohol mixes 13min, filters to obtain solids again after stirring, continues solids grinding 9min, obtain modified starch, by weight
Number meter is measured, 40 parts of self-control sugar coating materials, 7 parts of Modified Shell-lac for Cuprous Surface Anticorrosion, 4 portions of modified starches and 11 parts of deionized water mixing is weighed respectively and stirs
10min is mixed, obtains mixing suspension, then adds 3 parts of peach gums, 2 portions of sucrose and 3 parts of silica gel into mixing suspension and is placed in mixer
In, 1.5h is mixed at 40 DEG C, dries discharging, as makes sugar-coat solid by oneself, self-control sugar-coat solid is added to deionization
In water, 50min is mixed, sugar-coat solid suspension is obtained, Chinese medicine solid to be coated is added in coating pan, start bag
Clothing pot, hot blast is blown into coating pan, Chinese medicine solid to be coated is preheated into 35 DEG C, then sugar-coat solid suspension is sprayed onto and treated
On the Chinese medicine solid of coating, Cotton seeds 1.5h, discharging, you can damp-proof Chinese medicine sugar-coat is made.
Example 3
It is 1 in mass ratio:1 by ethyl cellulose and diethylamine cellulose acetate mixed grinding 10min, obtains cellulose powder,
The sodium hydroxide solution that 100mL mass fractions are 8% is added into cellulose powder and mixes 16min, is added after stirring
12mL3- chloro-2-hydroxypropyl-trimethyl ammonium chlorides, after continuing hybrid reaction 10min at 50 DEG C, it is put into baking oven, at 65 DEG C
2h is dried, as makes modified cellulose by oneself, then 200 are crossed after weighing 110g self-control modified celluloses and 12g talcum powder mixed grindings
Mesh sieve, sieving powder is collected, 20mL polyethylene glycol is sequentially added into sieving powder and 12mL ATBCs mix
5min, place into and dry 2h in baking oven at 85 DEG C, as make sugar coating material by oneself, it is standby, it is in mass ratio 3:1 by shellac and urine
Element mixing, heating stirring 50min, obtains mixture at 160 DEG C, and after it is cooled to room temperature, mixing is added into mixture
The beet oil of amount of substance 5% and the biogas slurry of mixture quality 0.6%, are fitted into fermentation tank, are sealed by fermentation 8 days at 45 DEG C, fermented
After end, tunning is taken out, as Modified Shell-lac for Cuprous Surface Anticorrosion, continue to weigh 40g cornstarch and pour into the burning containing 100mL deionized waters
12min is mixed in cup, cornstarch suspension is obtained, is by volume 4:1 by cornstarch suspension and absolute ethyl alcohol
15min is mixed, filters to obtain solids again after stirring, continues solids grinding 10min, obtain modified starch, by weight
Number meter is measured, 50 parts of self-control sugar coating materials, 8 parts of Modified Shell-lac for Cuprous Surface Anticorrosion, 5 portions of modified starches and 12 parts of deionized water mixing is weighed respectively and stirs
12min is mixed, obtains mixing suspension, then adds 4 parts of peach gums, 3 portions of sucrose and 4 parts of silica gel into mixing suspension and is placed in mixer
In, 2h is mixed at 50 DEG C, dries discharging, as makes sugar-coat solid by oneself, self-control sugar-coat solid is added to deionized water
In, 60min is mixed, sugar-coat solid suspension is obtained, Chinese medicine solid to be coated is added in coating pan, starts coating
Pot, hot blast is blown into coating pan, Chinese medicine solid to be coated is preheated into 40 DEG C, then sugar-coat solid suspension is sprayed onto and waits to wrap
On the Chinese medicine solid of clothing, Cotton seeds 2h, discharging, you can damp-proof Chinese medicine sugar-coat is made.
The damp-proof Chinese medicine sugar-coat that comparative example is produced with Shanghai City company is as a comparison case to produced by the present invention anti-
Damp-proof Chinese medicine sugar-coat in tidal stencils Chinese medicine sugar-coat and comparative example carries out performance detection, and testing result is as shown in table 1:1st, test
Method:
The Chinese medicine sugar-coat in the Chinese medicine sugar-coat and example 1~3 in the comparative example of equivalent is taken, is applied to four identical tablets respectively
On, it is positioned in four cups, places it in open storage environment, observation tablet situation of change is as follows:
Table 1
Note:Open storage environment:Relative humidity is 85%, 26 DEG C of temperature.
It can be seen from data in table 1, damp-proof Chinese medicine sugar-coat produced by the present invention with air indoors exposure when
Between change, the water content of dragee also changes therewith, but the dragee moisture change of the present invention is small, and the sugar in comparative example
Conspicuousness change occurs for the moisture of clothing pill, it can be clearly seen that damp-proof Chinese medicine sugar-coat produced by the present invention has anti-well
Damp performance, there is wide utilization prospect.
Claims (7)
1. a kind of preparation method of damp-proof Chinese medicine sugar-coat, it is characterised in that specifically preparation process is:
(1)By ethyl cellulose and diethylamine cellulose acetate mixed grinding, cellulose powder is obtained, is added into cellulose powder
Enter the mixing of 80~100mL sodium hydroxide solutions, 10~12mL3- chloro-2-hydroxypropyl-trimethyl ammonium chlorides added after stirring,
After continuing hybrid reaction, it is put into baking oven and dries, as make modified cellulose by oneself;
(2)200 mesh sieves are crossed after weighing 80~110g self-control modified celluloses and 10~12g talcum powder mixed grindings again, were collected
Powder is sieved, 12~20mL polyethylene glycol is sequentially added into sieving powder and 8~12mL ATBCs mix, then is put
Enter in baking oven and dry, as make sugar coating material by oneself, it is standby;(3)Shellac and urea Hybrid Heating are stirred, mixture is obtained, treats
After it is cooled to room temperature, the beet oil of mixture quality 5% and the biogas slurry of mixture quality 0.6% are added into mixture, is loaded
In fermentation tank, it is sealed by fermentation, after fermentation ends, takes out tunning, as Modified Shell-lac for Cuprous Surface Anticorrosion;
(4)Continue to weigh 20~40g cornstarch to pour into the beaker containing 80~100mL deionized waters and mix, obtain
Cornstarch suspension, cornstarch suspension and absolute ethyl alcohol are mixed, filter to obtain solids again after stirring, continued
Solids is ground, obtains modified starch;
(5)Count in parts by weight, weigh self-control sugar coating material, Modified Shell-lac for Cuprous Surface Anticorrosion, modified starch and deionized water respectively and mix,
Mixing suspension is obtained, then adds peach gum, sucrose and silica gel into mixing suspension and is placed in stirrer for mixing stirring, is dried out
Material, as make sugar-coat solid by oneself;
(6)Self-control sugar-coat solid is added in deionized water and mixed, sugar-coat solid suspension is obtained, in be coated
Medicine solid is added in coating pan, starts coating pan, hot blast is blown into coating pan, and Chinese medicine solid to be coated is preheated, then
Sugar-coat solid suspension is sprayed onto on Chinese medicine solid to be coated, Cotton seeds, discharged, you can damp-proof Chinese medicine sugar-coat is made.
A kind of 2. preparation method of damp-proof Chinese medicine sugar-coat according to claim 1, it is characterised in that:Step(1)Middle institute
The ethyl cellulose and the mass ratio of diethylamine cellulose acetate stated are 1:1, milling time is 8~10min, sodium hydroxide solution
Mass fraction be 8%, mixing time be 10~16min, and reaction temperature is 30~50 DEG C, and the reaction time is 8~10min, baking
Dry temperature is 45~65 DEG C, and drying time is 1~2h.
A kind of 3. preparation method of damp-proof Chinese medicine sugar-coat according to claim 1, it is characterised in that:Step(2)Middle institute
The mixing time stated is 3~5min, and drying temperature is 65~85 DEG C, and drying time is 1~2h.
A kind of 4. preparation method of damp-proof Chinese medicine sugar-coat according to claim 1, it is characterised in that:Step(3)Middle institute
The shellac and the mass ratio of urea stated are 3:1, whipping temp is 140~160 DEG C, and mixing time is 30~50min, fermentation temperature
For 35~45 DEG C, fermentation time is 6~8 days.
A kind of 5. preparation method of damp-proof Chinese medicine sugar-coat according to claim 1, it is characterised in that:Step(4)Middle institute
The mixing time stated is 10~12min, and the volume ratio of cornstarch suspension and absolute ethyl alcohol is 4:1, mixing time be 10~
15min。
A kind of 6. preparation method of damp-proof Chinese medicine sugar-coat according to claim 1, it is characterised in that:Step(5)Middle institute
The meter in parts by weight stated, weigh respectively 30~50 parts self-control sugar coating materials, 6~8 parts of Modified Shell-lac for Cuprous Surface Anticorrosion, 3~5 portions of modified starches,
10~12 parts of deionized waters, 2~4 parts of peach gums, 1~3 portion of sucrose and 2~4 parts of silica gel, mixing time are 8~12min, stirring temperature
Spend at 30~50 DEG C, mixing time is 1~2h.
A kind of 7. preparation method of damp-proof Chinese medicine sugar-coat according to claim 1, it is characterised in that:Step(6)Middle institute
The mixing time stated is 45~60min, and preheating temperature is 30~40 DEG C, and processing time is 1~2h.
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Application publication date: 20180109 |