CN112107413A - Preparation method of graphene medical antipyretic patch - Google Patents
Preparation method of graphene medical antipyretic patch Download PDFInfo
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- CN112107413A CN112107413A CN202011015160.5A CN202011015160A CN112107413A CN 112107413 A CN112107413 A CN 112107413A CN 202011015160 A CN202011015160 A CN 202011015160A CN 112107413 A CN112107413 A CN 112107413A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0203—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor
- A61F2007/0215—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor containing liquids other than water
- A61F2007/0219—Gels
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Abstract
The invention relates to the technical field of medical antipyretic patches, in particular to a preparation method of a graphene medical antipyretic patch, which comprises the following steps: the method comprises the following steps: preparing a graphene oxide dispersion liquid; step two: preparing a hydrogel; step three: and (3) preparing a graphene hydrogel mixed solution, adding the graphene oxide dispersion liquid obtained in the step one into the hydrogel obtained in the step two, stirring and mixing uniformly, and irradiating with ultraviolet rays in the stirring process to prepare the graphene hydrogel mixed solution. Step four: and D, cooling the graphene hydrogel mixed solution obtained in the step three at room temperature, and injecting the cooled graphene hydrogel mixed solution into a mold to obtain the graphene medical cooling patch. The product of the invention can rapidly take away human body heat to play a role in cooling due to high water content, and meanwhile has a function of rapidly conducting heat due to the existence of the graphene material, thereby being beneficial to rapid cooling; the graphene oxide is reduced by ultraviolet irradiation, so that harmful reducing agents are prevented from being introduced, and the product is purer.
Description
Technical Field
The invention relates to the technical field of medical antipyretic patches, in particular to a preparation method of a graphene medical antipyretic patch.
Background
Fever is a disease signal that can reflect the evolution of disease conditions in vivo or suggest the presence of underlying disease and can be used as an important reference for diagnosis, judgment and prognosis. Fever is one of the most prominent symptoms of infectious diseases. Common cooling methods include: rapid cooling, drug cooling, skin cooling, saline enema, oral cold drink and acupuncture. There are two main ways of cooling the fever stage of common infectious diseases in clinic, one is physical cooling and the other is medicinal cooling. The novel physical cooling method mainly refers to a hydrogel cooling paste cooling method, and the cooling principle is that the physical conversion mode of converting liquid into gas is used for physical cooling, so that the purpose of local cooling is achieved. However, the existing cooling paste has poor cooling effect and contains trace harmful components.
Disclosure of Invention
In order to overcome the defects of the existing antipyretic patch technology, the invention provides a preparation method of a graphene medical antipyretic patch.
The technical scheme adopted by the invention for solving the technical problems is as follows: a preparation method of a graphene medical antipyretic patch comprises the following steps:
the method comprises the following steps: preparing graphene oxide dispersion liquid, namely, putting the graphite oxide prepared by the Staudenmaier method into medical purified water for dispersion, simultaneously adding ammonia water and medical 75% ethanol;
step two: preparing hydrogel, adding NP-700, CMC, dihydroxyaluminum glycinate, EDTA disodium salt, PVPK120, 10% tartaric acid aqueous solution, 0.1% brilliant blue aqueous solution, preservative (DMDMH), mint, borneol and PVPP in glycerol in batches, mixing and stirring, and then stirring in vacuum to obtain the hydrogel;
step three: and (3) preparing a graphene hydrogel mixed solution, adding the graphene oxide dispersion liquid obtained in the step one into the hydrogel obtained in the step two, stirring and mixing uniformly, and irradiating with ultraviolet rays in the stirring process to prepare the graphene hydrogel mixed solution.
Step four: and D, cooling the graphene hydrogel mixed solution obtained in the step three at room temperature, and injecting the cooled graphene hydrogel mixed solution into a mold to obtain the graphene medical cooling patch.
According to another embodiment of the invention, the graphene oxide dispersion liquid prepared in the first step has a concentration of 0.1-30mg/ml, a mass ratio of graphene oxide to ammonia water of 200-50:1, a concentration of ammonia water of 25%, and a mass ratio of purified water and 75% ethanol used for dispersing graphene oxide of 500-200: 1.
According to another embodiment of the present invention, the method further comprises the step two of using partially neutralized polyacrylic acid, carboxymethyl cellulose, dihydroxyaluminum aminoacetate, polyvinylpyrrolidone K120, hydantoin and cross-linked polyvinylpyrrolidone as NP-700, CMC, aluminum glycollate, PVPK120, preservative (DMDMH) and PVPP, respectively.
According to another embodiment of the present invention, the vacuum stirring in the second step is further performed for 60 to 120 minutes.
According to another embodiment of the present invention, the ultraviolet light wavelength in the step three is 400nm to 10 nm.
According to another embodiment of the present invention, further comprising the vacuum stirring in the third step is 90 to 180 minutes.
According to another embodiment of the invention, the graphene hydrogel dressing further comprises the following components in parts by weight: medical purified water: 50-60 parts of glycerol: 20-30 parts of PVPK 120: 4-8 parts, NP-700: 3-6 parts of 10% tartaric acid aqueous solution: 2-4 parts of PVPP: 0.5-2 parts of CMC: 0.3-1 part, 75% medical alcohol: 0.3-1 part of preservative (DMDMDMH): 0.1-0.5 parts of 0.1% brilliant blue aqueous solution: 0.1-0.4 parts of mint: 0.1-0.3 part, borneol: 0.1-0.3 parts of aluminum glycoxide: 0.1-0.2 parts of EDTA disodium salt: 0.1-0.2 parts and graphene: 1-5 parts.
The invention has the beneficial effects that: the product of the invention can rapidly take away human body heat to play a role in cooling due to high water content, and meanwhile has a function of rapidly conducting heat due to the existence of the graphene material, thereby being beneficial to rapid cooling; the graphene oxide is reduced by ultraviolet irradiation, so that harmful reducing agents are prevented from being introduced, and the product is purer.
Detailed Description
A preparation method of a graphene medical antipyretic patch comprises the following steps:
the method comprises the following steps: preparing graphene oxide dispersion liquid, namely, putting the graphite oxide prepared by the Staudenmaier method into medical purified water for dispersion, simultaneously adding ammonia water and medical 75% ethanol;
step two: preparing hydrogel, adding NP-700, CMC, dihydroxyaluminum glycinate, EDTA disodium salt, PVPK120, 10% tartaric acid aqueous solution, 0.1% brilliant blue aqueous solution, preservative (DMDMH), mint, borneol and PVPP in glycerol in batches, mixing and stirring, and then stirring in vacuum to obtain the hydrogel;
step three: and (3) preparing a graphene hydrogel mixed solution, adding the graphene oxide dispersion liquid obtained in the step one into the hydrogel obtained in the step two, stirring and mixing uniformly, and irradiating with ultraviolet rays in the stirring process to prepare the graphene hydrogel mixed solution.
Step four: and D, cooling the graphene hydrogel mixed solution obtained in the step three at room temperature, and injecting the cooled graphene hydrogel mixed solution into a mold to obtain the graphene medical cooling patch.
The concentration of the graphene oxide dispersion liquid prepared in the first step is 0.1-30mg/ml, the mass ratio of the graphene oxide to ammonia water is 200-50:1, the concentration of the ammonia water is 25%, and the mass ratio of purified water used for dispersing the graphene oxide to 75% ethanol is 500-200: 1.
NP-700, CMC, aluminum glycollate, PVPK120, preservative (DMDMH) and PVPP used in step two were partially neutralized polyacrylic acid, carboxymethylcellulose, aluminum dihydroxyaminoacetate, polyvinylpyrrolidone K120, hydantoin and crosslinked polyvinylpyrrolidone, respectively.
And the vacuum stirring in the second step is 60-120 minutes, the ultraviolet wavelength in the third step is 400-10 nm, and the vacuum stirring in the third step is 90-180 minutes.
The graphene hydrogel dressing obtained in the third step comprises the following components in parts by weight: medical purified water: 50-60 parts of glycerol: 20-30 parts of PVPK 120: 4-8 parts, NP-700: 3-6 parts of 10% tartaric acid aqueous solution: 2-4 parts of PVPP: 0.5-2 parts of CMC: 0.3-1 part, 75% medical alcohol: 0.3-1 part of preservative (DMDMDMH): 0.1-0.5 parts of 0.1% brilliant blue aqueous solution: 0.1-0.4 parts of mint: 0.1-0.3 part, borneol: 0.1-0.3 parts of aluminum glycoxide: 0.1-0.2 parts of EDTA disodium salt: 0.1-0.2 parts and graphene: 1-5 parts.
The product of the invention can rapidly take away human body heat to play a role in cooling due to high water content, and meanwhile has a function of rapidly conducting heat due to the existence of the graphene material, thereby being beneficial to rapid cooling; the graphene oxide is reduced by ultraviolet irradiation, so that harmful reducing agents are prevented from being introduced, and the product is purer.
The larger the moisture content in the hydrogel is, the better the cooling effect of the product is; the graphene has quick heat-conducting property, and can effectively realize heat transfer; according to the invention, a plurality of effective volatile liquids such as water and medical alcohol are utilized, and graphene is used as a heat conducting component, so that rapid heat dissipation can be effectively realized, and the product can be widely applied to medical defervescence.
The first embodiment is as follows: the method comprises the following steps: preparing a graphene oxide dispersion liquid with the concentration of 0.1mg/ml, putting the graphite oxide prepared by the Staudenmaier method into medical purified water for dispersion, simultaneously adding ammonia water and medical 75% ethanol, wherein the mass ratio of the graphene oxide to the ammonia water is 200:1, the concentration of the ammonia water is 25%, and the mass ratio of the purified water for dispersing the graphene oxide to the 75% ethanol is 500: 1;
step two: preparing hydrogel, adding NP-700, CMC, dihydroxyaluminum glycinate, EDTA disodium salt, PVPK120, 10% tartaric acid aqueous solution, 0.1% brilliant blue aqueous solution, preservative (DMDMH), mint, borneol and PVPP in glycerol in batches, mixing and stirring, and then stirring in vacuum for 60 minutes to obtain the hydrogel;
step three: preparing a graphene hydrogel mixed solution, adding the graphene oxide dispersion liquid obtained in the step one into the hydrogel obtained in the step two, uniformly stirring and mixing, stirring in vacuum for 90 minutes, and irradiating by using ultraviolet rays in the stirring process, wherein the wavelength of the ultraviolet rays is 400nm, so as to prepare the graphene hydrogel mixed solution; the graphene hydrogel dressing comprises the following components in parts by weight: medical purified water: 50 parts of glycerol: 20 parts of PVPK 120: 4 parts, NP-700: 3 parts of 10% tartaric acid aqueous solution: 2 parts of PVPP: 0.5 part, CMC: 0.3 part, 75% medical alcohol: 0.3 part of preservative (DMDMDMH): 0.1 part of 0.1% brilliant blue aqueous solution: 0.1 part, mint: 0.1 part, borneol: 0.1 part, aluminum glycoxide: 0.1 part, EDTA disodium salt: 0.1 part and graphene: 1 part.
Step four: and D, cooling the mixed solution obtained in the step three at room temperature, and injecting the cooled mixed solution into a mold to obtain the graphene medical cooling paste.
Example two: the method comprises the following steps: preparing a graphene oxide dispersion liquid with the concentration of 15mg/ml, putting the graphite oxide prepared by the Staudenmaier method into medical purified water for dispersion, simultaneously adding ammonia water and medical 75% ethanol, wherein the mass ratio of the graphene oxide to the ammonia water is 125:1, the concentration of the ammonia water is 25%, and the mass ratio of the purified water for dispersing the graphene oxide to the 75% ethanol is 350: 1;
step two: preparing hydrogel, adding NP-700, CMC, dihydroxyaluminum glycinate, EDTA disodium salt, PVPK120, 10% tartaric acid aqueous solution, 0.1% brilliant blue aqueous solution, preservative (DMDMH), mint, borneol and PVPP in glycerol in batches, mixing and stirring, and then stirring for 90 minutes in vacuum to obtain the hydrogel;
step three: preparing a graphene hydrogel mixed solution, adding the graphene oxide dispersion liquid obtained in the step one into the hydrogel obtained in the step two, uniformly stirring and mixing, stirring in vacuum for 135 minutes, and irradiating by using ultraviolet rays in the stirring process, wherein the wavelength of the medium ultraviolet rays is 205nm, so as to prepare the graphene hydrogel mixed solution; the graphene hydrogel dressing comprises the following components in parts by weight: medical purified water: 55 parts and glycerin: 25 parts of PVPK 120: 6 parts, NP-700: 4.5 parts of 10% tartaric acid aqueous solution: 3 parts of PVPP: 1.25 parts, CMC: 0.65 part, 75% medical alcohol: 0.65 parts of preservative (DMDMDMH): 0.3 part of 0.1% brilliant blue aqueous solution: 0.25 part, mint: 0.2 part, borneol: 0.2 part, aluminum glycoxide: 0.15 part, EDTA disodium salt: 0.15 part and graphene: and 3 parts.
Step four: and D, cooling the mixed solution obtained in the step three at room temperature, and injecting the cooled mixed solution into a mold to obtain the graphene medical cooling paste.
Example three: the method comprises the following steps: preparing a graphene oxide dispersion liquid with the concentration of 30mg/ml, putting the graphite oxide prepared by the Staudenmaier method into medical purified water for dispersion, simultaneously adding ammonia water and medical 75% ethanol, wherein the mass ratio of the graphene oxide to the ammonia water is 50:1, the concentration of the ammonia water is 25%, and the mass ratio of the purified water for dispersing the graphene oxide to the 75% ethanol is 200: 1;
step two: preparing hydrogel, adding NP-700, CMC, dihydroxyaluminum glycinate, EDTA disodium salt, PVPK120, 10% tartaric acid aqueous solution, 0.1% brilliant blue aqueous solution, preservative (DMDMH), mint, borneol and PVPP in glycerol in batches, mixing and stirring, and then stirring in vacuum for 120 minutes to obtain the hydrogel;
step three: preparing a graphene hydrogel mixed solution, adding the graphene oxide dispersion liquid obtained in the step one into the hydrogel obtained in the step two, uniformly stirring and mixing, stirring in vacuum for 180 minutes, and irradiating by using ultraviolet rays in the stirring process, wherein the wavelength of the ultraviolet rays is 400nm, so as to prepare the graphene hydrogel mixed solution; the graphene hydrogel dressing comprises the following components in parts by weight: medical purified water: 60 parts of glycerol: 30 parts, PVPK 120: 8 parts, NP-700: 6 parts of 10% tartaric acid aqueous solution: 4 parts, PVPP: 2 parts of CMC: 1 part, 75% medical alcohol: 1 part of preservative (DMDMDMH): 0.5 part of 0.1% brilliant blue aqueous solution: 0.4 part, mint: 0.3 part, borneol: 0.3 part, aluminum glycoxide: 0.2 part, EDTA disodium salt: 0.2 part and graphene: 5 parts of the raw materials.
Step four: and D, cooling the mixed solution obtained in the step three at room temperature, and injecting the cooled mixed solution into a mold to obtain the graphene medical cooling paste.
The foregoing description is intended to be illustrative rather than limiting, and it will be appreciated by those skilled in the art that many modifications, variations or equivalents may be made without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (7)
1. A preparation method of a graphene medical antipyretic patch is characterized by comprising the following steps:
the method comprises the following steps: preparing graphene oxide dispersion liquid, namely, putting the graphite oxide prepared by the Staudenmaier method into medical purified water for dispersion, simultaneously adding ammonia water and medical 75% ethanol;
step two: preparing hydrogel, adding NP-700, CMC, dihydroxyaluminum glycinate, EDTA disodium salt, PVPK120, 10% tartaric acid aqueous solution, 0.1% brilliant blue aqueous solution, preservative (DMDMH), mint, borneol and PVPP in glycerol in batches, mixing and stirring, and then stirring in vacuum to obtain the hydrogel;
step three: and (3) preparing a graphene hydrogel mixed solution, adding the graphene oxide dispersion liquid obtained in the step one into the hydrogel obtained in the step two, stirring and mixing uniformly, and irradiating with ultraviolet rays in the stirring process to prepare the graphene hydrogel mixed solution.
Step four: and D, cooling the graphene hydrogel mixed solution obtained in the step three at room temperature, and injecting the cooled graphene hydrogel mixed solution into a mold to obtain the graphene medical cooling patch.
2. The preparation method of the graphene medical antipyretic patch as claimed in claim 1, wherein the concentration of the graphene oxide dispersion liquid prepared in the first step is 0.1-30mg/ml, the mass ratio of graphene oxide to ammonia water is 200-50:1, the concentration of ammonia water is 25%, and the mass ratio of purified water and 75% ethanol used for dispersing graphene oxide is 500-200: 1.
3. The preparation method of the graphene medical antipyretic patch as claimed in claim 1, wherein in the second step, the NP-700, CMC, dihydroxyaluminum glycinate, PVPK120, preservative (DMDMDMH) and PVPP are partially neutralized polyacrylic acid, carboxymethylcellulose, dihydroxyaluminum aminoacetate, polyvinylpyrrolidone K120, hydantoin and crosslinked polyvinylpyrrolidone respectively.
4. The preparation method of the graphene medical antipyretic patch as claimed in claim 1, wherein vacuum stirring in the second step is 60-120 minutes.
5. The preparation method of the graphene medical antipyretic patch as claimed in claim 1, wherein the wavelength of ultraviolet light in the third step is 400nm-10 nm.
6. The preparation method of the graphene medical antipyretic patch as claimed in claim 1, wherein vacuum stirring in the third step is 90-180 minutes.
7. The preparation method of the graphene medical antipyretic patch as claimed in claim 1, wherein the graphene hydrogel dressing obtained in the third step comprises the following components in parts by weight: medical purified water: 50-60 parts of glycerol: 20-30 parts of PVPK 120: 4-8 parts, NP-700: 3-6 parts of 10% tartaric acid aqueous solution: 2-4 parts of PVPP: 0.5-2 parts of CMC: 0.3-1 part, 75% medical alcohol: 0.3-1 part of preservative (DMDMDMH): 0.1-0.5 parts of 0.1% brilliant blue aqueous solution: 0.1-0.4 parts of mint: 0.1-0.3 part, borneol: 0.1-0.3 parts of aluminum glycoxide: 0.1-0.2 parts of EDTA disodium salt: 0.1-0.2 parts and graphene: 1-5 parts.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112940284A (en) * | 2021-01-27 | 2021-06-11 | 嘉兴职业技术学院 | Graphene/cellulose hydrogel capable of dissipating heat quickly and cooling patch thereof |
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