CN1827128A - Shuanghuanglian medicine for vagina and preparation method thereof - Google Patents
Shuanghuanglian medicine for vagina and preparation method thereof Download PDFInfo
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- CN1827128A CN1827128A CN 200510045956 CN200510045956A CN1827128A CN 1827128 A CN1827128 A CN 1827128A CN 200510045956 CN200510045956 CN 200510045956 CN 200510045956 A CN200510045956 A CN 200510045956A CN 1827128 A CN1827128 A CN 1827128A
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- 239000003814 drug Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 210000001215 vagina Anatomy 0.000 title claims description 3
- 239000009254 shuang-huang-lian Substances 0.000 title description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 42
- 239000000284 extract Substances 0.000 claims abstract description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000002674 ointment Substances 0.000 claims abstract description 7
- 239000006210 lotion Substances 0.000 claims abstract description 6
- 235000011187 glycerol Nutrition 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 239000002904 solvent Substances 0.000 claims abstract description 4
- 229920000159 gelatin Polymers 0.000 claims abstract description 3
- 235000019322 gelatine Nutrition 0.000 claims abstract description 3
- 241000555682 Forsythia x intermedia Species 0.000 claims abstract 2
- 241000207929 Scutellaria Species 0.000 claims abstract 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 229920002472 Starch Polymers 0.000 claims description 8
- 239000008107 starch Substances 0.000 claims description 8
- 235000019698 starch Nutrition 0.000 claims description 8
- 239000000758 substrate Substances 0.000 claims description 8
- 241000628997 Flos Species 0.000 claims description 7
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 6
- 239000011230 binding agent Substances 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 239000000945 filler Substances 0.000 claims description 4
- 239000004088 foaming agent Substances 0.000 claims description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
- 239000001530 fumaric acid Substances 0.000 claims description 3
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- OIALAIQRYISUEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]e Polymers CCCCCCCCCCCCCCCCCC(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO OIALAIQRYISUEV-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- 239000001828 Gelatine Substances 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
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- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 2
- 239000004327 boric acid Substances 0.000 claims description 2
- 235000010338 boric acid Nutrition 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 claims description 2
- 235000019868 cocoa butter Nutrition 0.000 claims description 2
- 229940110456 cocoa butter Drugs 0.000 claims description 2
- 238000004132 cross linking Methods 0.000 claims description 2
- JZZIHCLFHIXETF-UHFFFAOYSA-N dimethylsilicon Chemical compound C[Si]C JZZIHCLFHIXETF-UHFFFAOYSA-N 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 235000019441 ethanol Nutrition 0.000 claims description 2
- 125000005456 glyceride group Chemical group 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- -1 hydroxypropyl Chemical group 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 239000000314 lubricant Substances 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 235000016337 monopotassium tartrate Nutrition 0.000 claims description 2
- 229940056211 paraffin Drugs 0.000 claims description 2
- 239000012188 paraffin wax Substances 0.000 claims description 2
- 229960000502 poloxamer Drugs 0.000 claims description 2
- 229920001983 poloxamer Polymers 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- KYKNRZGSIGMXFH-ZVGUSBNCSA-M potassium bitartrate Chemical compound [K+].OC(=O)[C@H](O)[C@@H](O)C([O-])=O KYKNRZGSIGMXFH-ZVGUSBNCSA-M 0.000 claims description 2
- 229940086065 potassium hydrogentartrate Drugs 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 235000010413 sodium alginate Nutrition 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 claims description 2
- 239000011975 tartaric acid Substances 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- 229940099259 vaseline Drugs 0.000 claims description 2
- 239000002244 precipitate Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 1
- 229940126680 traditional chinese medicines Drugs 0.000 claims 1
- 239000003826 tablet Substances 0.000 abstract description 5
- 239000000499 gel Substances 0.000 abstract description 4
- 241000205585 Aquilegia canadensis Species 0.000 abstract description 2
- 239000002552 dosage form Substances 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 239000007938 effervescent tablet Substances 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000003 vaginal tablet Substances 0.000 abstract 1
- 229940044977 vaginal tablet Drugs 0.000 abstract 1
- 239000012567 medical material Substances 0.000 description 7
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 239000000546 pharmaceutical excipient Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
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- 238000002156 mixing Methods 0.000 description 3
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- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 239000004141 Sodium laurylsulphate Substances 0.000 description 2
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- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
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- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000003871 white petrolatum Substances 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
- 238000012356 Product development Methods 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
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- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
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- 239000003889 eye drop Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
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- 230000001717 pathogenic effect Effects 0.000 description 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 1
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention relates to a vaginal medicine made up by using honeysuckle flower, scutellaria root and forsythia fruit through a certain preparation process. The invention can add proper medicinal base (or auxiliary materials) to prepare lotion, ointment, gel, vaginal tablet and other dosage forms according to the need of medication, the lotion is mainly a liquid preparation prepared from traditional Chinese medicine extract and water or ethanol and other solvents, the ointment and the gel are mainly medicaments prepared from glycerin, gelatin, semisynthetic fatty acid and other medicinal bases, and the tablets comprise common tablets and effervescent tablets.
Description
Technical field the invention belongs to medical technical field, relating to Shuanghuanglian vaginal with medicine and preparation method thereof, is exactly lotion, ointment, gel and tablet etc. that SHUANGHUANLIAN drug extract and various medicinal substrate (or adjuvant) are mixed and made into and preparation method thereof particularly.
The pure Chinese medicinal preparation that the background technology 'Shuang Hualian ' mainly is made up of Rhizoma Coptidis, Flos Lonicerae and Fructus Forsythiae has antibiotic, antiviral and anti-infectious function, is mainly used in fevers caused by exogenous pathogenic factors such as treatment upper respiratory tract infection, pneumonia.Determined curative effect, steady quality, toxic and side effects are few, have been widely used in clinical.Domestic scholars has been carried out broad research to pharmacological action, clinical practice and the product development of 'Shuang Hualian ', the SHUANGHUANLIAN applied research scientific seminar that holds of 92 years Chinese Pharmaceutical Association only, piece paper is participated in interchange surplus just having 260, treatment case 30,000 examples, kind surplus sick kind reaches 40, and the research report increases gradually.'Shuang Hualian ' has multiple dosage forms such as injection, oral liquid, tablet (oral), granule, eye drop at present, does not see the report of Shuanghuanglian vaginal with preparation both at home and abroad.The vagina that is caused by antibacterial, virus etc. is frequently-occurring disease, commonly encountered diseases, and Shuanghuanglian vaginal has curative effect preferably with preparation to such disease, and this invention has stronger practicality.
The summary of the invention 'Shuang Hualian ' mainly is made up of Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae.
Get the Radix Scutellariae section, add 8～20 times of decoctings and boil (2,1,1 hours) three times, gradation filters, and merging filtrate also is concentrated in right amount, and concentrated solution adds hydrochloric acid (2mol/l) and transfers pH to 1～2 in the time of 80 ℃, in 80 ℃ of insulations 1 hour, left standstill 12 hours, and filtered, precipitation adds 6～8 amount distilled water, sodium hydroxide with 40% is transferred pH to 7.0, and adding equivalent ethanol, stirring makes molten, filters, filtrate is transferred pH to 2.0 with hydrochloric acid (2mol/l), in 60 ℃ of insulations 30 minutes, left standstill 12 hours, precipitation is washed till pH to 4.0 with ethanol, wave most ethanol, standby.
Extracting honeysuckle, Fructus Forsythiae add 8～20 times of water loggings and decoct secondary after 0.5 hour, each 1.5 hours, gradation filters, merging filtrate also is concentrated into relative density 1.20～1.25 (70～80 ℃), stirs when being chilled to 40 ℃ down slowly to add ethanol, makes solution contain the alcohol amount and reaches 75%, left standstill 12 hours, filter, filtrate recycling ethanol is to relative density 1.25～1.30 (70～80 ℃), and is standby.
Get the said extracted thing and mix, standby; Or drying under reduced pressure, standby after pulverizing.
Shuanghuanglian vaginal of the present invention ointment, gel, except that principal agent Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae extract, also comprise medicinal substrate, wherein calculate by weight percentage and contain principal agent (in medical material) 1～95%, medicinal substrate 5～99%, medicinal substrate comprise one or more in glycerin gelatine, cocoa butter, semi-synthetic or complete synthesis fatty glyceride, polyethylene glycols, polyoxyethylene (40) monostearate esters, poloxamer, carbomer, vaseline, paraffin, lanoline, the dimethyl-silicon wet goods substrate.
Shuanghuanglian vaginal of the present invention with tablet except that principal agent Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae extract, also comprise pharmaceutic adjuvant, wherein calculate by weight percentage and contain principal agent (in medical material) 1～95%, pharmaceutic adjuvant 5～99%, pharmaceutic adjuvant comprise one or more in foaming agent, disintegrating agent, filler, binding agent, the lubricant.Foaming agent comprises boric acid, citric acid, sodium bicarbonate, tartaric acid, potassium hydrogen tartrate, in the fumaric acid one or more, disintegrating agent comprises carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, sodium carboxymethyl cellulose, microcrystalline Cellulose, in the starch one or more, filler comprises lactose, sucrose, sorbitol, mannitol, in pregelatinized Starch and the starch one or more, binding agent comprises water, ethanol, polyvinylpyrrolidone, starch, hydroxypropyl emthylcellulose, sodium alginate, Magnesiumaluminumsilicate, in hydroxy methocel and the methylcellulose one or more.
Shuanghuanglian vaginal of the present invention with lotion except that principal agent Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae extract, also comprise pharmaceutic adjuvants such as solvent, wherein calculate by weight percentage and contain principal agent (in medical material) 1～95%, pharmaceutic adjuvant 5～99%, pharmaceutic adjuvant comprise one or more in water, ethanol, glycerol, propylene glycol, the Polyethylene Glycol equal solvent.
The specific embodiment is described in further detail the present invention by the following examples, but does not represent the embodiment limitation of the present invention.
Embodiment 1.
Prescription:
Composition weight (g)
Chinese medicine extract (in medical material) 2000
Polyethylene Glycol 3,350 400
PEG400 600
Preparation method: after two kinds of Polyethylene Glycol are mixed, in water-bath, be heated to 60 ℃, get the substrate that SHUANGHUANLIAN extract fine powder adds above-mentioned fusing and grind evenly, promptly get ointment.
Embodiment 2.
Prescription:
Composition weight (g)
Chinese medicine extract (in medical material) 2000
White vaseline 250
Stearyl alcohol 220
Sodium lauryl sulphate 15
Propylene glycol 120
Water 100
Preparation method: get stearyl alcohol and white vaseline melts in water-bath, add molten in advance (or suspendible) in water and be heated to 75 ℃ sodium lauryl sulphate, propylene glycol and Chinese medicine extraction liquid, be stirred to condensation, promptly get ointment.
Embodiment 3.
Prescription:
Composition weight (g)
Chinese medicine extract (in medical material) 5000
Sodium bicarbonate 200
Citric acid 150
Fumaric acid 100
PVP?K30 20
Low-substituted hydroxypropyl cellulose 8
Magnesium stearate 3
Preparation method: with Chinese medicine extract fine powder and other component (except the magnesium stearate) mixing, get PVPK30 and make 8% solution with dissolve with ethanol, as binding agent, add binding agent and stir evenly, granulate, 80 ℃ of oven dry add magnesium stearate, and mixing is suppressed 1000.
Embodiment 4.
Prescription:
Composition weight (g)
Chinese medicine extract (in medical material) 2000
50% ethanol 2000
Preparation method: get SHUANGHUANLIAN Chinese medicine extraction liquid and 50% alcoholic solution mixing, filter, promptly get lotion.
Claims (6)
1. woman vagina medicine, it is characterized in that: it mainly is made up of following parts by weight of traditional Chinese medicines: 20～80 parts of 10～50 parts of Fructus Forsythiaes of 10～50 parts of Radix Scutellariaes of Flos Lonicerae, wherein Radix Scutellariae makes extract through decocting, precipitate with ethanol dried, and Flos Lonicerae and Fructus Forsythiae are handled through blister, decocting, precipitate with ethanol, drying (in case of necessity) and made extract.
2. according to right 1 described medicine, it is characterized in that: one or more ointments of making, the gel in Chinese medicine extract and suitable glycerin gelatine, cocoa butter, semi-synthetic or complete synthesis fatty glyceride, polyethylene glycols, polyoxyethylene (40) monostearate esters, poloxamer, carbomer, vaseline, paraffin, lanoline, the dimethyl-silicon wet goods substrate.
3. according to right 1 described medicine, it is characterized in that: one or more liquid preparations such as lotion that are mixed and made in Chinese medicine extract and suitable water, ethanol, glycerol, propylene glycol, the Polyethylene Glycol equal solvent.
4. according to right 1 described medicine, it is characterized in that: one or more tablets made in Chinese medicine extract and suitable foaming agent, disintegrating agent, filler, binding agent, the lubricant.
5. according to right 4 described tablets, it is characterized in that: foaming agent comprises boric acid, citric acid, sodium bicarbonate, tartaric acid, potassium hydrogen tartrate, in the fumaric acid one or more, disintegrating agent comprises carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, sodium carboxymethyl cellulose, microcrystalline Cellulose, in the starch one or more, filler comprises lactose, sucrose, sorbitol, mannitol, in pregelatinized Starch and the starch one or more, binding agent comprises water, ethanol, polyvinylpyrrolidone, starch, hydroxypropyl emthylcellulose, sodium alginate, Magnesiumaluminumsilicate, in hydroxy methocel and the methylcellulose one or more.
6. according to claim 1 to 5, it is characterized in that: the method that Chinese medicine extract and suitable medicinal substrate (or adjuvant) is prepared medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510045956 CN1827128A (en) | 2005-03-02 | 2005-03-02 | Shuanghuanglian medicine for vagina and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510045956 CN1827128A (en) | 2005-03-02 | 2005-03-02 | Shuanghuanglian medicine for vagina and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1827128A true CN1827128A (en) | 2006-09-06 |
Family
ID=36945810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510045956 Pending CN1827128A (en) | 2005-03-02 | 2005-03-02 | Shuanghuanglian medicine for vagina and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1827128A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048759A (en) * | 2009-11-03 | 2011-05-11 | 深圳市嘉轩医药科技发展有限公司 | Gamuzhuer vagina tablet and preparation method thereof |
| CN107376034A (en) * | 2017-09-04 | 2017-11-24 | 中国热带农业科学院热带作物品种资源研究所 | Plant polypeptide soluble oil and preparation method thereof |
| CN108992518A (en) * | 2018-10-08 | 2018-12-14 | 于萍 | A kind of gynaecology's antibacterial liquid of mild and preparation method thereof |
| CN110302166A (en) * | 2019-07-19 | 2019-10-08 | 杨慧慧 | A kind of swap buffers tablet and preparation method thereof |
-
2005
- 2005-03-02 CN CN 200510045956 patent/CN1827128A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048759A (en) * | 2009-11-03 | 2011-05-11 | 深圳市嘉轩医药科技发展有限公司 | Gamuzhuer vagina tablet and preparation method thereof |
| CN107376034A (en) * | 2017-09-04 | 2017-11-24 | 中国热带农业科学院热带作物品种资源研究所 | Plant polypeptide soluble oil and preparation method thereof |
| CN108992518A (en) * | 2018-10-08 | 2018-12-14 | 于萍 | A kind of gynaecology's antibacterial liquid of mild and preparation method thereof |
| CN110302166A (en) * | 2019-07-19 | 2019-10-08 | 杨慧慧 | A kind of swap buffers tablet and preparation method thereof |
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