JPH01151524A - 'satotsu-ko' poultice and preparation thereof - Google Patents

Abstract

PURPOSE:To obtain a SATOTSU-KO (a compounded Chinese drug poultice) free from seepage of colored oily substance from the surface or back surface of the poultice, having excellent water-retainability, visco-elasticity, peelability and stability and having improved permeability of the principal drug component into the skin, by using a hydrophilic polymer, a natural rubber or a synthetic rubber as a base agent. CONSTITUTION:A SATOTSU-KO composition composed of 1,000pts. of sesame oil, 170-270pts. of beeswax, 50-70pts. of lard and 750-850pts. of bitumen is compounded to a plaster base containing one or more kinds of materials selected from hydrophilic polymer (e.g. sodium arginate or carrageenan), natural rubber or synthetic rubber which may be added with a surfactant. The compounded mixture is uniformly kneaded and the obtained plaster is spread on a supporting material to obtain the objective poultice. The amounts of the SATOTSU-KO composition, the hydrophilic polymer and the rubber component are preferably 5-50wt.%, 0.5-15wt.% and 2.0-25wt.% based on the whole plaster, respectively.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a patch containing a composition of left plaster and a method for producing the same.

Left ointment has been known as one of the Chinese herbal medicines for external use since ancient times, and is used to treat a variety of diseases. In other words, the left-hand plaster contains 1,000 parts of sesame oil, 220 parts of yellow wax, 5.3 parts of pork fat, and 800 parts of plaster, and is effective in treating purulent swelling.

As a Chinese herbal medicine preparation, Zuo-tou-yun has conventionally been used in the form of a dosage form that is applied directly to the skin or applied to a base cloth and then applied to the affected area.

However, such ointment formulations are +11. When used, a colored oily liquid oozes out from the back side of the ointment or the base fabric on which it is applied, staining the skin and clothing, and the contamination can be removed by washing. (2) Poor applicability to the base fabric (cannot apply a certain amount of ointment to a uniform thickness (3) Winter ointment tends to solidify and is difficult to apply to the base fabric as well as the skin. The ointment has poor spreadability and is difficult to spread sufficiently and apply. However, the reality is that it has not come into widespread use.

Based on the above state of the art, the present inventors investigated whether colored oil exudates in the form of poultices conventionally used for the purpose of analgesic and anti-inflammatory purposes. When trial production was carried out by mixing the used base and left plaster in various ratios, it was found that in all such combinations, the paste was not evenly kneaded and a large amount of oily components remained in liquid form. It turned out that it was not even possible to obtain a shape-retaining plaster.

Moreover, it has been found that the oily components, especially the pork fat, used in left bulges are prone to rancidity and have stability problems, such as emitting a peculiar odor over time.

As a result of our further pursuit to provide a formulation that overcomes the above-mentioned difficulties while making full use of Chinese herbal formulas established through numerous clinical experiences since ancient times, we unexpectedly discovered sodium alginate, sodium carboxymethyl cellulose, sodium polyacrylate, When using a hydrophilic polymer such as carrageenan, carboxymethyl cellulose, methyl vinyl ether maleic anhydride copolymer, natural or synthetic rubber, or a mixture thereof, or a patch base containing a surfactant in addition to these.

It was discovered that a gel with high viscosity and excellent shape retention was formed by uniformly mixing the composition of the Chinese herbal medicine prescription Zuobutsu, without impairing the medicinal efficacy of the leftobutsu, and the exudation of colored oily components was suppressed. As a result, the present invention was completed.

The present invention is completely new in that it uses left plaster in the form of a poultice, and is groundbreaking in that it can provide a preparation that eliminates all the drawbacks of conventional left plaster.

In other words, the left plaster patch provided by the present invention does not exude colored oil from the plaster surface or the back surface of the base fabric, and has water retention, viscoelasticity, and peelability.

It has excellent stability, increases the permeability of the active ingredient into the skin, has a good adhesion to the skin, does not leave any paste on the skin after use, and maintains the active ingredient and base ingredient for a long time. It never changes in quality.

In addition, methyl vinyl ether maleic anhydride copolymer (trade name: GANTREZ, G
When maintaining the fluidity of the entire plaster at a weakly acidic level by adding organic acids, etc. (manufactured by companies A and F), the stabilization of the herbal medicine components is enhanced and irritation to the affected area can be reduced.

The present invention is particularly useful when blending lard, sesame oil, and yellow wax in amounts prescribed in Chinese herbal medicine prescriptions.

Furthermore, the present invention is characterized in that it is formulated into a patch without essentially impairing the medicinal efficacy of the left plaster.

The ingredients used are not limited to only crude drugs, but may include water, organic solvents, extracts extracted with water-containing organic solvents, essential oils and active ingredients isolated from crude drugs, and include all of these.

Examples of organic solvents for extraction include lower alcohols such as methanol and ethanol, polar solvents such as acetone and ethyl acetate, and nonpolar organic solvents such as ether, benzene, and hexane. In addition, examples of essential oils and active ingredients isolated from crude drugs include turpentine oil and rosin contained in plasters.

In addition, in the already established Zuo-yume, the blending ratio of the ingredients used in its formulation is determined, and it goes without saying that the composition of the Chinese herbal formula of the present invention is manufactured using the predetermined blending ratio. It is also possible to manufacture the compound at a blending ratio that is appropriately increased or decreased within a range that does not impair the efficacy of the Chinese herbal prescription.

That is, for 1.000 parts of sesame oil, 750 parts of yellow wax
A blending ratio of 850 parts is preferred.

When crude drug extracts, essential oils or active ingredients isolated from crude drugs are used as the main drug ingredients in the composition of the Chinese herbal medicine prescription Zuotou-yun, the amount to be blended is based on the amount calculated from the content in the crude drug. It will be decided as appropriate.

In addition, sesame oil and yellow wax are used for the left plaster.

Although pork fat itself has useful medicinal properties, it also acts as an ointment base for other medicinal ingredients. Therefore, these ingredients are different from other medicinal ingredients, namely plasters.

The desired purpose can be achieved even if the blending ratio is changed relatively significantly. Further, depending on the purpose and necessity, these components may be replaced with other similar base materials or may be omitted. for example.

When essential oils or active ingredients isolated from the plaster are used as the main medicinal ingredients of the plaster, the corresponding medicinal effects can be achieved even if the base ingredients such as sesame oil are removed. The compositions also include compositions in which these external herbal medicine bases are replaced with other similar bases or are omitted.

In addition, if necessary, salicylic acid esters such as methyl salicylate and glycol salicylate, which have been widely used in the field of poultices for the purpose of analgesia and anti-inflammation;

Capsicum extract, eucalyptus oil, vitamin E.

It is free to further add drugs such as vitamin E esters and diphenhydramine hydrochloride to the composition of the above-mentioned Chinese herbal prescription Zuo-tou-yun.

The amount to be used of the composition of the Chinese herbal medicine formulation of the left plaster in the present invention is appropriately selected depending on the type of patch base, etc.2, but it is preferably 1 to 80% by weight based on the total amount of the preparation, and is determined by the left plaster. 5 to 50% by weight if the composition is manufactured with a blending ratio of
is suitable.

Hydrophilic polymers used in the present invention include sodium alginate, sodium carboxymethyl cellulose, sodium polyacrylate, carrageenan, carboxymethyl cellulose, methyl vinyl ether maleic anhydride copolymer, propylene glyco-alginate ester, and hectin. , sunsan gum, locust bingham, guar gum, alapiano galactan.

Holivinyl alcohol, polyvinylpyrrolidone.

carboxyvinyl polymers (carbopho-#) and the like, especially sodium alginate.

Preferred are sodium carboxymethyl cellulose, sodium polyacrylate, carrageenan, carboxymethyl cellulose, and methyl vinyl ether maleic anhydride copolymers.

These hydrophilic polymers can be used alone or in combination of two or more in an appropriate ratio. The amount of hydrophilic polymer to be used needs to be selected appropriately, taking into account the type of hydrophilic polymer used and the amount of the composition of the Chinese herbal medicine prescription left plaster.
Usually 0.1 to 25% by weight, especially 0.5 to 25% by weight based on the total amount of the precursor
A range of 15 weight is appropriate. When using a mixture of two or more types of hydrophilic polymers, the total amount used may be within the above range.

Furthermore, natural or synthetic rubber refers not only to raw rubber obtained from natural products and synthetic rubber such as S, B, and R rubber, but also to latex emulsions using these rubbers. The latex emulsion used usually has a rubber content of about 40 to 70%.

The amount of natural or synthetic rubber to be used is appropriately determined in consideration of the amount of the composition of the Chinese herbal medicine formulation Zuobutsu plaster used, but it is 1.0 to 40% by weight based on the total amount of the plaster.

In particular, a range of 2.0 to 25 weight is preferred.

In addition, as surfactants, polyoxyethylene higher fatty acid ester, polyoxyethyledisorbitan higher fatty acid ester, sorbitan higher fatty acid ester, polyoxyethylene castor oil derivative, polyoxyethylene hydrogenated castor oil derivative, polyoxyethylene higher alcohol Examples include ether, polyoxyethylene alkylaryl ether, etc., especially polyoxyethylene sorbitan higher fatty acid esters (trade name: Tween) such as polyoxyethylene rubitan monostearate, polyoxyethylene sorbitan monopalmitate, and sorbitan monostearate. .

Sorbitan higher fatty acid esters (trade name: Span) such as nrubitan sesquiolate are preferred.

The amount of the surfactant to be used may be appropriately selected depending on the amount of the composition of the Chinese herbal medicine prescription Zuotouyin, etc., and is approximately 0.2 to 10% by weight, preferably 0.5 to 5% by weight.

In addition to organic acids, polymeric substances with an acidic pH such as methyl vinyl ether maleic anhydride copolymer (product name: GANTREZ) and carboxyvinyl polymer (product name: CARBON) are used to maintain the liquid properties of the entire plaster to be weakly acidic. pole) can also be used.

The organic acid itself has properties as a patch base, but also serves as a pH adjuster. Such organic acids include acetic acid, succinic acid, citric acid, malic acid, fumaric acid, maleic acid, tartaric acid, and the like.

To produce the plaster patch of the present invention, (1) first use the ingredients used in the plaster as they are, (2) or add sesame oil extract of the plaster, beeswax, pork fat, or (3)
A preparation of the left patch is prepared in advance according to the method prescribed in the Chinese herbal prescription for external use; it is mixed into a patch base and kneaded uniformly to form a paste.

The adhesive base includes the hydrophilic polymer, natural or synthetic rubber, surfactant, other medicinal ingredients, gelatin, water, and powder excipients if necessary.

Antioxidants, emollients, astringents, and other base agents are used.

For the strings, powder excipients include kaolin, bentonite, zinc oxide, titanium oxide, synthetic aluminum silicate, etc., and antioxidants include guaiacol esters, butylhydroxyanisole, dibutylhydroxytoluene, nordihydroguaiaretic acid. Liquid paraffin, silicone, vegetable oil, higher fatty acid ester, etc. are used as softeners, and aluminum chloride is used as an astringent.

Salts that generate trivalent metal ions such as aluminum sulfate and alum, etc., and other bases include adhesives such as polybutene, gum arabic and ester gum, humectants such as alkaline earth metal salts and polyhydric alcohols, Examples include preservatives such as methylparaben and ethylparaben.

The rosin contained in the plaster acts as an adhesive, and the thymol can also serve as a preservative.

These bases are used in appropriate amounts in consideration of the properties of the resulting paste.

In addition, when manufacturing the adhesive patch of the present invention, the order of addition and kneading should be set in consideration of the physicochemical properties of the base used, or heating treatment should be carried out in order to facilitate the machine balancing operation. You are free to do what you want.

Next, the paste thus obtained is spread and coated onto a support while being maintained at an appropriate temperature, a release coating is further laminated thereon, and the paste is cut into an appropriate size. The support is fabric,
A non-woven fabric, 9 paper, 1 synthetic resin film, etc. are used, and a raised fabric such as flannel is particularly preferred. Examples of release coatings include polyethylene, cellophane, and plastic films.

Note that the technology of the present invention can also be applied to rubber plasters, and the present invention is not limited only to hydrophilic plasters, but also includes plasters in the form of bone.

EXAMPLES The present invention will be explained in more detail by way of examples below.

In addition, in the method of preparing the patch of the present invention by preparing the plaster in advance and then blending it with a patch base.

The composition of the left plaster was manufactured by the following method.

Boil 1,000 parts of sesame oil well to evaporate the water, then add 220 parts of beeswax and 58 parts of pork fat and dissolve.

Next, add 800 parts of plaster, dissolve, and filter through a cloth.

Boil further to increase the consistency and cool while stirring to obtain a homogeneous ointment.

Example 1: Dissolve 0.2 parts of citric acid in 200 parts of purified water, add 25.0 parts of kaolin, 0.1 part of zinc oxide, and 0.5 parts of titanium oxide.

5.0 parts of gelatin, 1.5 parts of sodium alginate, and 15.0 parts of glycerin were added and kneaded, and 2.0 parts of methyl vinyl ether maleic anhydride copolymer was dissolved in 9.4 parts of purified water. To this were added 10.0 parts of left plaster prepared separately in advance, 5.0 parts of liquid paraffin, 0.5 parts of polyoxyethylene sorbitan monostearate (Tween 60), and 4 parts of natural rubber latex. .0 parts, S, B, R, latex 0°5
1.0 parts of polybutene, an antioxidant, and a preservative are added in small amounts, and after uniformly kneading at 50°C, it is spread on a flannel, and a plastic film is pasted on the surface to give it a predetermined size. Cut it right.

Example 2 A left plaster patch containing 30% left plaster was produced in the same manner as in Example 1.

Claims (7)

[Claims] (1) Patch containing the composition of Chinese herbal medicine formulation (2) The Chinese herbal prescription composition contains 1,000 parts of sesame oil, 170 to 270 parts of yellow wax, 50 to 70 parts of pork fat, and 750 parts of plaster.
850 copies. Patch according to claim (1) (3) The patch according to claim (1), which contains the composition of a Chinese herbal medicine formulation and a patch base. (4) The patch base contains one or more selected from the group consisting of hydrophilic polymers, natural rubber, and synthetic rubber, or a surfactant added thereto.
) or the patch described in (3) (5) Sesame oil, yellow wax, and pork fat, which are the ingredients of left paste,
Or, a left patch with a Chinese herbal prescription, which is characterized in that a left patch prepared based on a Chinese herbal prescription is blended into a patch base, kneaded uniformly, and the resulting paste is spread and applied on a support. Method for producing a patch containing a plaster composition (6) The Chinese herbal prescription composition contains 1,000 parts of sesame oil, 170 to 270 parts of yellow wax, 50 to 70 parts of pork fat, and 750 parts of plaster.
850 copies of the manufacturing method according to claim (5) (7) The patch base has as an essential component one or more selected from the group consisting of hydrophilic polymers, natural rubber, and synthetic rubber, or a surfactant further added thereto. Manufacturing method described in section 5)