JPH08188527A - Sheet-like pack agent - Google Patents

Abstract

PURPOSE: To obtain a sheet-like pack agent usable for a quasi-drug or a cosmetic used for conditioning and beautifying of the skin by including a water-soluble polymer, a polyhydric alcohol, a humectant component, a curing agent, a skin beautifying component and water as active components, and further added with an antiseptic agent, as necessary. CONSTITUTION: This sheet-like pack agent contains a water-soluble polymer (suitably gelatin or a polyacrylic acid salt), a polyhydric alcohol (suitably glycols), a humectant component (suitably an aqueous solution of an acylated kefiran or an extract of malt), a curing agent (suitably a hardly water-soluble aluminum compound or a polyfunctional epoxy compound), a skin beautifying component (suitably an extract of placenta or allantoin) and water. The pack agent may further be added with an antiseptic agent (e.g. benzoic acid). The pack agent is simply handled and has a suitable tackiness to the skin and a use feeling, and furthermore, has an excellent safety to the skin and is remarkably excellent in stability of preparation properties with passage of time, and also, has an excellent cooling effect due to a high water content to induce a comfortable refrigerant feeling.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a sheet-like pack agent used for quasi-drugs or cosmetics for skin conditioning and beauty.

[0002]

2. Description of the Related Art In recent years, as a packing agent, a packing agent containing a water-soluble polymer such as polyvinyl alcohol and having an O / W type emulsion or jelly-like film forming ability is commercially available. This type of pack is intended to replenish the components in the pack by taking a necessary amount at the time of use and applying it to the face, and removing the stain and aged keratin by peeling after drying. However, this type of pack agent has a problem that the hands are soiled during application, a post-residue is liable to occur at the time of peeling, and it takes a long time to dry, and thus lacks in convenience. Therefore, for the purpose of improving these problems, a pack agent containing polyacrylic acid salt, polyhydric alcohol and water as a main component and having excellent water retention and low peeling force (JP-A-54-49334) and polyacrylic acid. salt,
A pack agent containing an excipient as a main component and having excellent shapeability and excellent water retention (Japanese Patent Publication No. 63-15243), and a sheet-like pack agent using a crosslinkable hydrogel as a base material (Japanese Patent Publication No. No. 46485, JP-B-63-60724, JP-A-58-180408, JP-A-61-260007), and a skin having an excellent feeling of use containing a naturally-derived moisturizing component. External preparation (JP-A-5-301
No. 812), a pack agent and a poultice agent in which a semi-synthetic ingredient derived from a natural source is blended as a moisturizer and a thickener (Japanese Patent Application Laid-Open No. Hei 5)
-295004) is disclosed.

[0003]

However, the above-mentioned conventional packs and sheet-like packs have a problem that they lack appropriate tackiness to the skin and lack in usability. Since the stability of formulation properties over time is poor, there is a problem in that it is poor in storability and safety in skin. In addition, since the moisturizing component in the preparation has excellent compatibility, it lacks replenishment of moisture to the skin and release of the moisturizing component, and as a result, the pack effect on the skin is weak. In addition, the formulation itself lacks water retention and has the problem that it cannot give the moisturizing feeling to the skin most effectively.

The present invention solves the above-mentioned problems of the prior art, is easy to use, has appropriate adhesiveness and moisturizing properties to the skin, is excellent in the stability of formulation properties and is safe to the skin, and is used. It is an object of the present invention to provide a highly water-containing sheet-like pack which is excellent in feeling during use and a pack effect on the skin.

[0005]

To achieve this object, the sheet-like pack agent of the present invention has the following constitution. That is, the sheet-like pack agent according to claim 1 is
The water-soluble polymer, the polyhydric alcohol, the moisturizing component, the crosslinking agent, the skin beautifying component, and water are contained as essential components. According to a second aspect of the present invention, in the sheet-shaped pack agent according to the first aspect, a preservative is added to the essential components. The sheet-like pack according to claim 3 is the same as in claim 1, wherein the water-soluble polymer in the essential components is 3 to 25% by weight, the polyhydric alcohol is 1 to 35% by weight, and the moisturizing component is 0. 0.01 to 20% by weight, the crosslinking agent is 0.05 to 20% by weight, the skin beautifying component is 0.01 to 20% by weight, and the water is 60 to 95% by weight.
Has a configuration that is The sheet-like pack agent according to claim 4 has a structure according to claim 2, wherein the amount of the preservative compounded in the essential components is 0.005 to 10% by weight. According to a fifth aspect of the present invention, in the sheet-like pack agent according to the first or third aspect, the water-soluble polymer is composed of one or more of gelatin and polyacrylate. The sheet-like pack agent according to claim 6 has the structure according to claim 1 or 3, wherein the polyhydric alcohol is a glycol. The sheet-like pack according to claim 7 is the sheet pack according to claim 1 or 3, wherein the moisturizing component is an acylated kefiran aqueous solution or malt extract.
It has a configuration of two or more species. The sheet-like pack agent according to claim 8 is the same as in claim 1 or 3,
The cross-linking agent is composed of one of a poorly water-soluble aluminum compound and a polyfunctional epoxy compound, or a combination thereof. According to a ninth aspect of the present invention, in the sheet-like pack agent according to the first or third aspect, the skin beautifying component is composed of one or two of water-soluble placenta extract and allantoin. If necessary, an antioxidant, a tackifier, a solubilizer, a dye, a fragrance, a surfactant, an ultraviolet absorber, an inorganic filler and a pH adjuster can be added to the preparation.

Here, examples of the water-soluble polymer include gelatin and polyacrylic acid salts, which can be used alone or in combination. As the salts of polyacrylic acid salts, metal salts such as sodium, lithium and potassium are preferable, and their average degree of polymerization is 1000 to 100.
Those of 000 are preferably used. The content of these water-soluble polymers is 3 to 25% by weight, preferably 5 to 20%.
%, More preferably 5-10% by weight. When the content is less than 5% by weight, the adhesiveness, cohesiveness, shape retention, water absorption capacity, etc. of the preparation may be reduced, resulting in uneven application of the paste, deterioration in workability and deterioration in usability. If it is less than 3% by weight, the tendency tends to be remarkable, which is not preferable. In addition, as the blending amount becomes 10% by weight or more, the adhesiveness, cohesiveness, and shape retention of the preparation become poor, and the viscosity becomes excessively high during the production, and the plaster becomes uneven and the workability is deteriorated. And a tendency to cause a decrease in usability is apt to occur. 2
If it exceeds 5% by weight, the tendency tends to be remarkable, which is not preferable.

As the polyhydric alcohol, glycols are preferable, and they are used as a dispersing / dissolving agent or plasticizer for water-soluble polymers, moisturizing ingredients, cross-linking agents, skin-beautifying ingredients, preservatives, etc., and release and volatilization of water. It can promote sex. Glycols listed here have a polyether structure, and are less hydrophilic because they have fewer hydroxyl groups than commonly used low molecular weight polyhydric alcohols. It is possible to reduce the critical relative humidity of the agent components, and during use,
More water can be released to the outside. As a result, it moisturizes the skin and removes heat of vaporization due to the evaporation of water to the outside, which suppresses the burning and inflammation of the face and at the same time provides a pleasant cooling sensation. Further, the temperature dependence of the viscosity is smaller than that of commonly used low molecular weight polyhydric alcohols, and stable shape retention that is not affected by environmental changes can be exhibited even when incorporated into a preparation. As the glycols having a polyether structure, polyethylene glycol having an average molecular weight of 200 to 600 and polypropylene glycol having an average molecular weight of 500 to 3000 are preferable, and one or more of these may be mixed and used. The amount of this polyhydric alcohol blended is 1 to
It is used at 35% by weight, preferably 5 to 25% by weight, more preferably 5 to 20% by weight. As the blending amount becomes 5% by weight or less, the adhesiveness and cohesiveness of the preparation, the deterioration of water retention and shape retention before use, the non-uniformity of gel, the deterioration of workability, the feeling during use and after use Of less than 1% by weight is not preferable because the tendency is particularly remarkable. Also, as the blending amount becomes 20% by weight or more, the adhesiveness and cohesiveness of the preparation, the water retention and shape retention before use begin to decrease, and the workability decreases and the feel during use and after use deteriorates. However, if it exceeds 35% by weight, this tendency is particularly remarkable, which is not preferable.

As the moisturizing component, an acylated kefiran aqueous solution (manufactured by Sansho Pharmaceutical Co., Ltd.) and / or malt extract is preferably used, and one or more of these may be used in combination. The aqueous solution of acylated kefiran is obtained by culturing a kefiran or kefiran-producing bacterium that has been extracted and purified from kefir or grains, and is purified by at least partial acylation with an acid anhydride or a carboxylic acid or its halide, and succinyl kefiran, Acetyl kefiran, maleyl kefiran and the like can be used. The aqueous solution of acylated kefiran has various pharmacological effects and imparts a function as a naturally derived moisturizing component. As the malt extract, an extract obtained by pressing malt of barley or a malt extract obtained by extraction with ethanol or a malt root extract obtained from malt root of malt barley (malt root) is used, and particularly malt Root extract is a factor that promotes the ability to produce fibroblast collagen, and is preferable in terms of the action of preventing skin aging and the like. The blending amount of these moisturizing components is 0.01 to 20% by weight,
Preferably 0.05 to 10% by weight, more preferably 0.
Used at 1-5% by weight. As the compounding amount becomes 0.1% by weight or less, there is a tendency that the water retention and shape retention of the preparation are deteriorated and the feeling of use during use and after use is deteriorated. It is not preferable because the tendency is remarkable. Further, as the blending amount becomes 5% by weight or more, the adhesiveness, cohesiveness, and shape retention of the preparation are decreased,
There is a tendency that the gel becomes non-uniform and the workability is deteriorated and the feeling during use and after use is deteriorated. When it exceeds 20% by weight, this tendency is particularly remarkable, which is not preferable.

As the cross-linking agent, a sparingly water-soluble aluminum compound or a polyfunctional epoxy compound may be used alone or in combination. The compounding ratio (weight ratio) of the poorly water-soluble aluminum compound (a) and the polyfunctional epoxy compound (b) of the compounding agent is a / b = 500/1 to 1/10. By using the compounding agent, it is possible to contribute to water retention when not in use, shape retention and excellent temporal stability of the physical properties of the preparation. As the poorly water-soluble aluminum compound, aluminum hydroxide, hydrous aluminum silicate, synthetic aluminum silicate, kaolin, aluminum acetate,
Examples thereof include aluminum lactate and aluminum stearate, and these can be used alone or in combination of two or more. Since a sparingly water-soluble aluminum compound is used, in addition to the effect of suppressing skin irritation due to antacid action and the skin astringent action due to a trace amount of aluminum ions, the initial physical properties give the gel appropriate strength as a filler, and
Aluminum ions are eluted in the preparation with the lapse of time, and can exhibit the function of compensating for the deterioration of the polymer with time and the decrease in gel strength due to the aging of the interpolymer covalent bond cross-linking portion. Furthermore, it is also possible to control the aluminum elution rate by adjusting the pH. Polyethylene glycol diglycidyl ether as a polyfunctional epoxy compound,
Ethylene glycol diglycidyl ether, glycerin diglycidyl ether, glycerin triglycidyl ether, propylene glycol diglycidyl ether, polyglycerol polyglycidyl ether, sorbitol polyglycidyl ether, sorbitan polyglycidyl ether, trimethylolpropane polyglycidyl ether, pentaerythritol polyglycidyl ether , Resorcinol diglycidyl ether, neopentyl glycol diglycidyl ether and the like. These polyfunctional epoxy compounds may be used alone or in combination of two or more. Since a polyfunctional epoxy compound is used, it is possible to obtain excellent water absorption capacity and shape retention, and to efficiently form a covalent bond with a water-soluble polymer having a carboxyl group, an amino group, a hydroxyl group, etc. Can be increased. The amount of cross-linking agent added to the formulation is 0.05
-20% by weight, preferably 0.5-15% by weight, more preferably 1-10% by weight. As the blending amount becomes 1% by weight or less, the cohesiveness and shape retention of the preparation, the water absorption capacity decrease, the deterioration of the stability of preparation properties over time, the workability decrease, the skin safety decrease and the feeling of use are reduced. A tendency to cause a decrease is recognized, and if it is less than 0.05% by weight, the tendency is particularly remarkable, which is not preferable. Further, as the blending amount becomes 10% by weight or more, tackiness, cohesiveness, shape retention, excessive increase in viscosity during production, non-uniformity of plaster due to gelation, deterioration of workability,
There is a tendency that the safety of the skin and the feeling of use are deteriorated, and if it exceeds 20% by weight, the tendency is particularly remarkable, which is not preferable.

As the skin beautifying component, one or more blends of water-soluble placenta extract and allantoin are preferably used. In addition, lecithin, amino acids, kojic acid, protein, saccharides, hormones, placenta extract, or extract components from various crude drugs such as aloe, loofah and licorice, or vitamin A, vitamin C, and vitamin D as other skin beautifying components. , Vitamin E and other vitamins and diphenhydramine hydrochloride, diphenhydramine salicylate, diphenhydramine tannate, triprolidine hydrochloride, mequitazine, chlorpheniramine maleate,
d-Chlorpheniramine maleate, clemastine fumarate, promethazine hydrochloride, tranilast, sodium cromoglycate, ketotifen, allylsulfatase B, bufexamac, bendazac, butyl flufenate, ibuprofen, indomethacin, aspirin, flurbiprofen, ketoprofen , Piroxicam and 2-pyridinemethylmefenamic acid, 5,6-dehydroarachidonic acid, 5,6-methano-LTA ₄ , esculetin, ubatilin, 4-demethyleubatilin, caffeic acid, benoxaprofen, etc. The drug having a can be used alone or in combination. The water-soluble placenta extract is an extract extracted after removing blood from the placenta of a healthy cow or a healthy pig, and has a whitening effect, a cell activation effect, a blood circulation promotion, a metabolism enhancement, a melanin production inhibitory effect, a cell proliferation effect and the like. Further, allantoin has an action of removing (exfoliating) necrotic tissue and scales, and at the same time, has an action of promoting the production of new skin tissue, cell proliferation, anti-allergy, anti-inflammatory, anti-stimulation and the like. The amount of the skin beautifying component is 0.01 to 20% by weight, preferably 0.05 to 10% by weight, more preferably 0.1 to 5% by weight. 0.1% by weight
As shown below, the skin-beautifying effect begins to decline, and the feeling of use during and after use tends to deteriorate.
If it is less than wt%, this tendency is particularly remarkable, which is not preferable. As the blending amount becomes 5% by weight or more, the adhesiveness and cohesiveness of the preparation, the deterioration of water retention and shape retention before use, the nonuniformity of gel, the deterioration of workability, the use during and after use A feeling tends to be deteriorated, and if it exceeds 20% by weight, this tendency becomes particularly remarkable, which is not preferable.

As water, purified water, sterilized water, or natural water is used. Water acts as a dispersing / dissolving agent for water-soluble polymers, moisturizing components, cross-linking agents, skin beautifying components, preservatives, etc., and also markedly improves the feeling during and after use.
Therefore, the content of water is 60 to 95% by weight, preferably 6
It should be added in a large amount of 5 to 90% by weight, more preferably 70 to 85% by weight. By including a large amount of water in the formulation, the relative humidity of the formulation itself can be increased, and the difference from the critical relative humidity described above can be made larger, so more water can be efficiently used during use. It becomes possible to discharge it to the outside, moisturizes the skin as a result, and removes heat of vaporization due to the evaporation of water to the outside,
It suppresses the burning and irritation of the face and at the same time gives a pleasant refreshing feeling. As the compounding amount becomes less than 70% by weight, it tends to cause a decrease in adhesiveness of the preparation, a decrease in water retention before use, a decrease in workability, and a feeling during use and after use, depending on the kind of compounding agent. However, if it is less than 60% by weight, this tendency is remarkable, which is not preferable. Moreover, the compounding amount is 85% by weight.
If the amount is more than 95% by weight, the adhesiveness and cohesiveness are likely to be impaired and the shape retention before use tends to be lowered.

Preservatives include paraoxybenzoic acid ester, benzoic acid, benzoate, salicylate, sorbic acid, sorbate, dehydroacetate, 4-isopropyl-3-methylphenol, 2-isopropyl-5-methyl. Phenol, phenol, hinokitiol, cresol, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarbanide, chlorobutanol, benzalkonium chloride, benzethonium chloride and the like are mentioned. It is possible to use one kind or a combination of two or more kinds. The compounding amount is 0.005 to 10% by weight, preferably 0.01 to 5% by weight, and more preferably 0.01 to 1% by weight. When the content is less than 0.01% by weight, the formulation tends to rot due to generation of mold and fungi during storage, and the feeling of use during use and after use tends to deteriorate. It is not preferable because the tendency is remarkable. Also, as the amount of compounding exceeds 1% by weight, the adhesiveness, cohesiveness, water retention and shape retention of the preparation decrease, gel non-uniformity, workability decrease, generation of preservative odor, use When used and after use, the feeling of use tends to deteriorate, and when it exceeds 10% by weight, this tendency is remarkable, which is not preferable.

The highly water-containing sheet-like pack of the present invention comprises a water-soluble polymer, a polyhydric alcohol, a moisturizing component, a cross-linking agent, a skin beautifying component, water and a preservative as well as a conventionally known antioxidant. Tackifier, solubilizer, dye, fragrance, surfactant,
Compounding agents such as an ultraviolet absorber, an inorganic filler and a pH adjusting agent can be appropriately mixed in an appropriate amount according to the application.

As antioxidants, ascorbic acid, propyl gallate, butylhydroxyanisole, dibutylhydroxytoluene, nordihydroguaiaretic acid,
Tocopherol, tocopherol acetate, etc. can be added. As a tackifier, casein, pullulan,
Agar, dextran, sodium alginate, soluble starch, carboxystarch, dextrin, carboxymethylcellulose, sodium carboxymethylcellulose, methylcellulose, ethylcellulose, hydroxyethylcellulose, polyvinyl alcohol, polyethylene oxide, polyacrylamide, polyacrylic acid,
Polyvinylpyrrolidone, carboxyvinyl polymer, polyvinyl ether, polymaleic acid copolymer, methoxyethylene maleic anhydride copolymer, isobutylene maleic anhydride copolymer, polyethyleneimine and the like can be blended. As the dissolving agent, benzyl alcohol, peppermint oil,
Isopropyl myristate, crotamiton, etc. can be added.

As the pigments, Red No. 2 (Amaranth), Red No. 3 (Erythrosin), Red No. 102 (New Coccin), Red No. 104 (1) (Ploxin B), Red No. 1
No. 05 (1) (Rose Bengal), Red No. 106 (Acid Red), Yellow No. 4 (Tartrazine), Yellow No. 5 (Sunset Yellow FCF), Green No. 3 (Fast Green FCF), Blue No. 1 (Brilliant) Blue FC
F), Blue No. 2 (Indigo Carmine) and the like may be incorporated. Although the dye is not particularly limited, it has a great influence on the image of the preparation and leads to improvement in the feeling of use and the feeling of activation of the skin.

As the surfactant, anionic surfactants such as sodium dioctyl sulfosuccinate, alkyl sulfate salt, sodium salt of 2-ethylhexyl alkyl sulfate ester, sodium normaldodecylbenzenesulfonate, hexadecyl trimethyl ammonium chloride, octadecyl dimethyl benzyl. Cationic surfactants such as ammonium chloride, polyoxyethylene dodecyl monomethyl ammonium chloride, polyoxyethylene stearyl ether, polyoxyethylene tridecyl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, polyoxyethylene monosteare Rate, sorbitan monostearate, sorbitan monopalminate, sorbitan sesquiole Over DOO, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monooleate, glycerol monostearate, polyglycerin fatty acid esters, nonionic surfactants such as polyoxyethylene octadecylamine etc. may be blended.

As the ultraviolet absorber, para-aminobenzoic acid, para-aminobenzoic acid esters, para-dimethylaminobenzoic acid amyl, salicylates, menthyl anthranilate, umbelliferone, esculin, benzyl cinnamate, cinoxate, guaiazulene, urocanine. Acid, 2- (2-hydroxy-5-methylphenyl) benzotriazole, 4-methoxybenzophenone, 2-
Hydroxy-4-methoxybenzophenone, dioxybenzone, octabenzone, dihydroxydimethoxybenzophenone, thrisobenzone, benzoresorcinol,
You may mix | blend octyl dimethyl para amino benzoate, ethylhexyl para methoxy cinnamate, etc.

As the inorganic filler, titanium oxide, talc, zinc oxide, hydrous silica, magnesium carbonate, calcium hydrogen phosphate, magnesium silicate, diatomaceous earth, anhydrous silicic acid, bentonite, etc. may be blended. As the pH adjuster, acetic acid, formic acid, lactic acid, tartaric acid, oxalic acid, benzoic acid, glycolic acid, malic acid, citric acid, hydrochloric acid, nitric acid, sulfuric acid, sodium hydroxide, potassium hydroxide, methylamine, ethylamine, propylamine, Dimethylamine, diethylamine, dipropylamine, trimethylamine, triethylamine, tripropylamine, monomethanolamine, monoethanolamine, monopropanolamine, dimethanolamine, diethanolamine, dipropanolamine, trimethanolamine, triethanolamine, tripropanolamine Etc. may be blended.

Examples of the base cloth include synthetic resin films such as polyethylene, polypropylene, ethylene-vinyl acetate copolymer, vinyl chloride, polyurethane, polyester, polyamide, rayon, polyurethane and polyester, elastic nonwoven fabric, non-woven paper, Laminates of synthetic resin films and sheets and non-woven fabric or non-woven paper, non-woven fabric such as absorbent cotton,
Examples of the flexible material include cloth, stretchable cloth, paper, and cellophane, which can be appropriately selected according to the application.
A pack agent layer is provided on a base fabric made of a flexible support, and the surface of the pack agent layer is further covered with a peelable film or paper. It is very convenient to attach the exposed pack agent layer to the face, etc. In addition, it is easy to use if a sheet-like material is punched or otherwise processed according to the adaptation site. The color of the base cloth is not particularly limited, but it has a great influence on the image of the preparation and leads to an improvement in the feeling of use and activation of the skin, such as white, flesh color, yellow, red, blue, green, blue, Pink, light blue, etc. are preferable.

The method for producing the sheet pack of high water content of the present invention is to uniformly mix and / or mix the above components in a stirrer.
Alternatively, it is dissolved, spread on a non-dyed or dyed base cloth, and a film is attached and cut into a face shape. Also cut the eyes, nose, mouth and chin into appropriate shapes,
It is as easy to handle as possible. The sheet-like pack agent is preferably stored in a hermetically-sealed container until it is used in order to prevent contamination during storage and a reduction in the effect due to evaporation of volatile substances.

[0021]

With this constitution, the highly water-containing sheet-like pack agent of the present invention can exhibit the following excellent actions. As the water-soluble polymer, 3 to 25% by weight is blended in the preparation to enhance the tackiness, cohesiveness and shape retention, and to reduce the water absorption ability and the unevenness of the plaster. It can prevent and improve usability. Further, these effects can be further enhanced by incorporating a predetermined amount of a metal salt of polyacrylic acid as a water-soluble polymer. Since polyhydric alcohols, especially glycols, are blended, water-soluble polymers, moisturizing ingredients, crosslinking agents, skin beautifying ingredients, preservatives, etc. can be uniformly dispersed and dissolved in the system to be homogenized. Also,
It promotes water release and volatility, and can lower the critical relative humidity of the base component excluding water.
Allows more water to be discharged. As a result, the skin is moisturized, and the heat of vaporization is taken away by the evaporation of water to the outside, so that the burning and inflammation of the face can be suppressed and at the same time a pleasant refreshing feeling can be given. In addition, glycols have a small temperature dependence of viscosity, and can provide stable shape-retaining properties that are not affected by environmental changes even when blended in a formulation. As a moisturizing ingredient, an aqueous solution of acylated kefiran (manufactured by Sansho Pharmaceutical Co., Ltd.) and malt extract are used, so the adhesiveness, cohesiveness, homogenization of gel, water retention and shape retention before use are maintained, and when used. And the feeling of use after use can be improved. As a cross-linking agent, any one of a sparingly water-soluble aluminum compound and a polyfunctional epoxy compound or a combination thereof is used, so that appropriate adhesiveness, cohesiveness and shape retention are imparted to the preparation, and the water absorption ability is also imparted. It is possible to maintain and prevent an excessive increase in viscosity during production, to homogenize the plaster by gelling, improve the safety on the skin and give a comfortable feeling of use. As a skin beautifying component, particularly when using a water-soluble placenta extract or allantoin, etc., it has a whitening effect and a cell activating effect, and promotes blood circulation, enhances metabolism, suppresses melanin production, and has a cell proliferation effect,
Furthermore, it promotes the generation of new skin tissue,
Anti-inflammatory and anti-irritant properties can be imparted to the preparation. Water uniformly disperses and dissolves the water-soluble polymer, the moisturizing component, the cross-linking agent, the skin beautifying component, the preservative and the like, and can form a homogeneous emulsion of the formulation together with other compounding agents. In addition, since the water content is high, the relative humidity of the preparation itself can be increased, and the difference from the critical relative humidity becomes larger, so more water can be efficiently discharged to the outside during use. It moisturizes the skin and removes heat of vaporization by evaporating water to the outside world, which can suppress burning and inflammation of the face and at the same time provide a pleasant refreshing feeling. Since a predetermined amount of the preservative is added, it is possible to prevent spoilage due to generation of mold and fungi in the preparation, and to give a comfortable feeling of use.

[0022]

EXAMPLES The sheet-like pack agent of the present invention will be described in more detail below with reference to Examples and Test Examples, but these do not limit the present invention in any way. Example 1 4% by weight of synthetic aluminum silicate was dispersed in 76.5% by weight of purified water, and 1% by weight of gelatin was added thereto.
0.1% by weight of 2% aqueous succinyl kefiran solution, 0.05% by weight of ethylene glycol diglycidyl ether, 2% by weight of water-soluble placenta extract, 0.1% by weight of allantoin, 0.2% by weight of methylparaben were added and dissolved, and further poly A mixture of 6% by weight of sodium acrylate, 10% by weight of polyethylene glycol and 0.05% by weight of propylparaben is added and stirred until uniform. Next, this is spread on a base cloth dyed in pale blue so as to have a thickness of about 1.4 mm, and a film is attached. After application, the product was cut into a face shape and the eyes, nose, mouth and jaw were cut into appropriate shapes to obtain a sheet-like pack. Then, using the obtained sheet-like pack agent, a stability test with time (Test Example 1) and a component release test (Test Example 2) described later were performed and evaluated.

(Examples 2 to 19) (Table 1) to (Table 3)
The sheet-like pack preparations of Examples 2 to 19 were prepared in the same manner as in Example 1 with the compounding agents and the compounding amounts shown in. Then, using the obtained sheet-like packs of Examples, a skin safety test (Test Example 3) and a feeling-of-use evaluation test (Test Example 4) described below were performed and evaluated. The acylated kefiran aqueous solution was a 1.5% succinyl kefiran aqueous solution (Example 3), a 3% succinyl kefiran aqueous solution (Example 4),
1% aqueous succinyl kefiran solution (Example 6), 5% aqueous succinyl kefiran solution (Example 8), 1% aqueous acetyl kefiran solution (Example 10), 10% aqueous acetyl kefiran solution (Example 11), 10% aqueous succinyl kefiran solution (Example 11) Example 13) 1% maleyl kefiran aqueous solution (example 14), 2% succinyl kefiran aqueous solution (example 15), and 10% maleyl kefiran aqueous solution (example 17) were used for the sheet-like packs of each example. Was produced.

[Table 1]

[Table 2]

[Table 3]

(Comparative Examples 1 to 5) With the compounding ingredients and the compounding amounts shown in Table 4, these are uniformly mixed and / or dissolved to obtain the pack agents and sheet-like pack agents shown in Comparative Examples 1 to 5. It was Comparative Examples 1 and 2 were used as a packing agent as they were in the later-described evaluation tests, and Comparative Examples 3 and 5 were used so that the base cloth had a thickness of about 1.4 mm.
About Comparative Example 4, a urethane film has a thickness of about 1 mm.
After spreading so as to form a sheet, the film was stuck and cut into a face shape, and used as a sheet-like pack agent in the evaluation test described below. The packing agent of the comparative example is disclosed in JP-A-54-493.
Formulation of Example 1 (Comparative Example 1) of JP-A-34-34 and JP-B-6
It was prepared according to the formulation of Example 1 (Comparative Example 2) of JP-A-3-15243. Further, the sheet-like packs of Comparative Examples 3 to 5 have the formulations of Example 1 of JP-A-61-260007 (Comparative Example 3) and the formulations of Example 3 of JP-B-63-60724 (Comparative Example). 4) and the formulation of Comparative Example 8 of JP-A-5-295004 (Comparative Example 5). In addition, Califlex TR-1107 is a trade name of Shell Chemical Co., Ltd., and Alcon M-70 is a trade name of Arakawa Chemical Industry Co., Ltd.

[Table 4]

(Test Example) (Test Example 1) Stability Test over Time A stability test of the physical properties of the preparation with time was carried out for each of the sheet-like packs of Example 1 and Comparative Examples 3, 4, and 5. As the test method, changes in the formulation with respect to adhesiveness, shape retention and hardness were observed at the initial stage and after storage at 40 ° C. for 6 months. The test results are shown in (Table 5).

[Table 5] As is clear from this (Table 5), the sheet-like pack agent of Example 1 did not show any change with time even under severe conditions, but the comparative example showed a remarkable change with time. That is, it was found that the shape retention and hardness of Comparative Example 3 deteriorated, the shape retention of Comparative Example 4 deteriorated, and the hardness of Comparative Example 5 deteriorated and could not be used.

(Test Example 2) Component Release Test The amount of the component released from the preparation was confirmed for each of the sheet-like packs of Example 1 and Comparative Examples 3, 4 and 5. The test method was to cut out a piece of 7 × 10 cm ² at a temperature of 25 ±
It was applied to the skin for 30 minutes and 60 minutes under the application condition of 1 ° C. and humidity of 60 ± 5%, and the weight after the removal was determined from the weight before the application to obtain the component release amount. The results are shown in (Table 6) and (Table 7). In addition, (Table 6) shows the amount of components released after 30 minutes from application, and (Table 7) shows the amount of components released after 60 minutes from application.

[Table 6]

[Table 7] As is clear from this (Table 6), the composition of Example 1 has a component release amount of 27.4% after 30 minutes, while the composition of Comparative Example has 15.5% (Comparative Example 3). 11.2
% (Comparative Example 4) and 11.5% (Comparative Example 5). Further, as is clear from (Table 7), the total release amount after 60 minutes was 52.5% in Example 1 and 35.7% in Comparative Example (Comparative Example 3). There were only 14.9% (Comparative Example 4) and 14.7% (Comparative Example 5). From this, it was found that the sheet-like pack agent of the present example has a remarkable component releasing action as compared with the comparative example.

Test Example 3 Skin Safety Test A skin safety test was carried out for Examples 2, 3, 7 and Comparative Examples 1-5. As a test method, 40 healthy men and women conducted a closed patch for 48 hours, observed the change state of the skin 1 hour and 24 hours after peeling, and evaluated the degree of skin irritation according to the following criteria. The test results are shown in (Table 8). −: No change on skin ±: Slight redness on skin +: Clear redness on skin ++: Severe skin contact

[Table 8] As is clear from this (Table 8), no positive rate was observed in any of the examples even after 24 hours from peeling, but 13% to 25% was observed in the comparative examples 4 and 5. It was From this, it is understood that the sheet-like pack agent of the present example has extremely low skin irritation and is gentle to human skin.

(Test Example 4) Usability evaluation test-sensory test A usability test was carried out on each of the sheet-shaped packs of Examples 4, 5, 6 and Comparative Examples 1 to 5. In the test method, 20 healthy females were evaluated before, during, after, and the next morning (after 24 hours) according to the following criteria, and an average of 5 grades (5 points out of 5) was calculated. The test results are shown in (Table 9), (Table 10), (Table 11) and (Table 12). Evaluation before use (Table 10) in each (Table 9)
Shows the evaluation at the time of use, (Table 11) shows the evaluation after use, and (Table 12) shows the evaluation the next morning (after 24 hours have passed). 5 points: I think very much 4 points: I think so slightly 3 points: I can not say either 2 points: I do not think so much 1 point: I do not think at all

[Table 9]

[Table 10]

[Table 11]

[Table 12] As is clear from (Table 9) to (Table 12), all of the examples of this example were able to obtain a high evaluation as compared with the comparative example. In addition, it was found that each of the examples gives a pleasant feeling without any discomfort during use as compared with the comparative example, and gives a refreshing feeling without the sticky feeling like the comparative example after the skin is moisturized. It was As described above, it was found that the highly water-containing sheet-like pack of the present invention has excellent skin safety and stability of formulation physical properties over time, high component (mainly water) release property, and high usability and effect on skin. .

[0029]

As described above, the sheet-like pack of the present invention contains a water-soluble polymer, a polyhydric alcohol, a moisturizing component, a cross-linking agent, a skin beautifying component, and water as main components, and if necessary, a preservative. The water-soluble polymer 3 to 2 is added.
5% by weight, polyhydric alcohol 1 to 35% by weight, moisturizing component 0.01 to 20% by weight, crosslinking agent 0.05 to 20% by weight,
Skin beautifying ingredient 0.01 to 20% by weight, water 60 to 95% by weight
Further, since the composition further contains 0.005 to 10% by weight of a preservative as required, the following excellent effects can be obtained. That is, a. It is easy to handle, has an appropriate adhesiveness to the skin, and has an excellent feeling of use. b. It excels not only in skin safety but also in stability of formulation properties over time. c. It has an excellent cooling effect due to its high water content and brings a pleasant refreshing feeling. d. It has an excellent endothermic effect due to its high water content, and has the effect of suppressing the burning and inflammation of the skin. e. It has an excellent moisturizing effect after use, moisturizes the skin,
Makes the skin smooth. f. Excellent effect on skin conditioning and beauty. g. Since it has an appropriate adhesiveness, it can be easily handled in the manufacturing process and give high productivity, and the stability of the formulation physical properties is high, so there is no change in physical properties during long-term storage, and storage and distribution It has excellent properties. h. It can be applied in the field of quasi drugs or cosmetics used for skin conditioning and beauty, and is extremely useful industrially.

Claims (9)

[Claims] 1. A sheet-like pack comprising a water-soluble polymer, a polyhydric alcohol, a moisturizing component, a cross-linking agent, a skin beautifying component, and water as essential components. 2. The sheet-like pack agent according to claim 1, wherein a preservative is mixed in the essential components. 3. The water-soluble polymer in the essential component is 3
25 wt%, the polyhydric alcohol is 1 to 35 wt%,
The moisturizing component is 0.01 to 20% by weight, the crosslinking agent is 0.05 to 20% by weight, and the skin beautifying component is 0.01 to 20% by weight.
%, And the water is 60 to 95% by weight. The sheet-like pack agent according to claim 1, wherein the water is 60 to 95% by weight. 4. The sheet-shaped pack agent according to claim 2, wherein the amount of the preservative compounded in the essential components is 0.005 to 10% by weight. 5. The sheet-like pack according to claim 1, wherein the water-soluble polymer is one or more of gelatin and polyacrylate. 6. The sheet-like pack according to claim 1, wherein the polyhydric alcohol is a glycol. 7. The sheet-like pack according to claim 1 or 3, wherein the moisturizing component comprises one or two kinds of an acylated kefiran aqueous solution and malt extract. 8. The sheet-like pack agent according to claim 1, wherein the cross-linking agent comprises one of a poorly water-soluble aluminum compound and a polyfunctional epoxy compound, or a combination thereof. 9. The sheet-like pack according to claim 1, wherein the skin beautifying component is composed of one or two of water-soluble placenta extract and allantoin.