CN105641733A - Preparation method for compound antibacterial haemostatic wound dressing - Google Patents
Preparation method for compound antibacterial haemostatic wound dressing Download PDFInfo
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- CN105641733A CN105641733A CN201511033800.4A CN201511033800A CN105641733A CN 105641733 A CN105641733 A CN 105641733A CN 201511033800 A CN201511033800 A CN 201511033800A CN 105641733 A CN105641733 A CN 105641733A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to a preparation method for a compound antibacterial haemostatic wound dressing. The preparation method comprises the following steps: preparing chitosan, carboxymethyl chitosan and sodium alginate serving as raw materials into a chitosan solution and a carboxymethyl chitosan solution; adding calcium chloride or an aldehyde cross-linking agent or a plant cross-linking agent and a povidone-iodine antibacterial agent into the chitosan solution or the carboxymethyl chitosan solution or a mixture of the chitosan solution and the carboxymethyl chitosan solution, and mixing uniformly; adding a mixed solution of sodium alginate, sodium hyaluronate and the like into a solution at a stage in which gel is not formed; coating the surface of a fiber water-absorbing cushion or a fiber non-woven fabric with the mixed solution, or placing the fiber water-absorbing cushion or the fiber non-woven fabric into the solution at the stage in which the gel is not formed for full soaking till saturation; performing freeze drying in vacuum to obtain a sponge-shaped solid. The preparation method has the beneficial effects that the antibacterial haemostatic wound dressing prepared according to the method is non-toxic, is free from a thermal source, is high in biocompatibility, and has the advantages of inhibiting growth of bacteria, preventing bacteria from entering a wound surface, promoting skin regeneration, accelerating healing, reducing scars and the like.
Description
Technical field:
The preparation method that the present invention relates to a kind of composite antibacterial bleeding-stopping dressing, belongs to medical antibacterial hemostasis technical field of medical instruments.
Background technology:
Antibacterial anti hemorrhagic is always up hospital surgical frequently problem, is also the difficult problem that is frequently encountered by of daily life. Medical dressing is that a class carries out the interim medical material covered for various wounds, wound surface, and it can make wound exempt from the impact of antibacterial infection and other foeign elements, plays the effect of protection wound, wound surface.
There is following requirement generally for wound dressing: (1) has the softness close with human body skin, when moistening, also can keep certain form and intensity; (2) moist environment of wound surface can be kept, have the ability absorbing wound exudate preferably, and have certain breathability; (3) dressing is nontoxic, the reaction that human body is not harmful to and stimulation and it is necessary to antibacterial can be stoped to enter wound surface in case causing superinfection, it is to avoid Wound contact particle and poisonous pollutant, without thermal source; (4) it is preferably formed with effects such as stopping blooding, relieve the pain, granulation growth and skin regeneration, healing acceleration can be promoted, reduce cicatrix; (5) excellent storage stability, it is desirable to have degradability, environment is not produced to pollute by garbage.
Chitin is the natural macromolecular material extracted the cell wall of the shell from the Crustacean such as shrimp, Eriocheir sinensis and bacterium, algae rudimentary plant, is be only second to cellulosic second largest biologically-derived resource in nature. Chitosan is the product of de-acetyl chitin, is unique alkaline polysaccharide in nature. In general, the N-acetyl group of chitin is sloughed more than 50% and is just properly termed as chitosan. Chitosan is a kind of high molecular polysaccharose substance of pure natural, and the toxicity research of chitosan shows, chitosan is substantially nontoxic, has good safety, good biocompatibility, it is possible to degraded and absorbed. Additionally, chitosan can also suppress various bacteria and the effect of fungus growth. Owing to having the physiologically active of uniqueness and excellence, chitosan application in wound dressing is increasingly becoming its focus in biomaterial is applied.
Calcium alginate is widely used as medical dressing, calcium alginate dressing is in that when wound fluid contacts, exchanged by ion, insoluble calcium alginate is made to form a kind of hydrogel after absorbing big quantity of fluid, there is provided a kind of moist environment for wound, and calcium alginate nonwoven is furnished with good hygroscopicity and hemostatic function.
Summary of the invention:
The preparation method that the present invention provides a kind of composite antibacterial bleeding-stopping dressing, antibacterial anti hemorrhagic dressing prepared by Using such method is nontoxic, and without thermal source, biocompatibility is high;There is bacteria growing inhibiting, stop antibacterial to enter wound surface, promote skin regeneration, healing acceleration, reduce the advantages such as cicatrix.
For reaching above-mentioned purpose, the technical solution used in the present invention is:
The preparation method of a kind of composite antibacterial bleeding-stopping dressing: with chitosan, carboxymethyl chitosan, sodium alginate for raw material, prepare chitosan solution and carboxymethyl chitosan solution. After chitosan solution or carboxymethyl chitosan solution or both solution are added calcium chloride or aldehyde crosslinking agent or plant extract cross-linking agent and betadine antiseptic mixing, the mixed solution of sodium alginate, hyaluronate sodium etc. is added at the solution not forming gel phase, coat fibrous absorbent pad or fabric nonwoven cloth surface, or fibrous absorbent pad or fabric nonwoven cloth be positioned in the solution not forming gel phase be completely soaked to saturated, become spongy solid through vacuum lyophilization.
Described prepare chitosan solution method be: dissolve the chitosan in acetum or 0.3��4% hydrochloric acid solution or 0.5��8% lactic acid solution or 0.5��10% glutamic acid solution or the compound two kinds sour of 0.5��5%, form the chitosan solution of 0.2��10%, 0.01��0.02% betagen solution can be simultaneously introduced.
The method of described preparation carboxymethyl chitosan solution is: carboxymethyl chitosan is soluble in water, forms the carboxymethyl chitosan solution of 0.2��10%, can be simultaneously introduced 0.01��0.02% betagen solution.
The crosslinking of described chitosan is: takes chitosan solution, presses: add glutaraldehyde or other cross-linking agent at 10: 3, and reaction temperature is 25��70 DEG C, mix homogeneously.
The crosslinking of described carboxymethyl chitosan is: go carboxymethyl chitosan solution, adds calcium chloride or the crosslinking of other aldehyde crosslinking agent by 10:2, and reaction temperature is 25��50 DEG C, mix homogeneously.
The invention has the beneficial effects as follows: antibacterial anti hemorrhagic dressing prepared by Using such method is nontoxic, without thermal source, biocompatibility is high; There is bacteria growing inhibiting, stop antibacterial to enter wound surface, promote skin regeneration, healing acceleration, reduce the advantages such as cicatrix.
Detailed description of the invention:
In order to make those skilled in the art be more fully understood that technical scheme, below in conjunction with specific embodiment, the present invention is described in further detail.
Embodiment 1
Taking 5 grams of solid chitosan dry powder, its deacetylation is 75%, molecular weight is 300,000, adds the acetum 100ml of 2%, fully dissolve, be filtered to remove insoluble matter, add glycerol appropriate, it is coated with or is soaked in chitosan needle punched non-woven fabrics surface, lyophilization 72 hours, obtaining spongy solid.
Embodiment 2
Take 3 grams of solid chitosan dry powder, its deacetylation is 85%, molecular weight is 350,000, add the acetum 100ml of 2%, fully dissolve, be filtered to remove insoluble matter, add glutaraldehyde weak solution, add glycerol 3-10ml after stirring mixing 0.5h and continue stirring mixing 0.5h, it is coated with or is soaked in chitin needle punched non-woven fabrics surface, lyophilization 72 hours, obtaining spongy solid.
Embodiment 3
Take 4 grams of solid chitosan dry powder, its deacetylation is 80%, molecular weight is 400,000, add the acetum 100ml of 2%, fully dissolve, be filtered to remove insoluble matter, add formaldehyde weak solution, add glycerol 3-10ml after stirring mixing 0.5h and continue stirring mixing 0.5h, it is coated with or is soaked in calcium alginate needle punched non-woven fabrics surface, lyophilization 72 hours, obtaining spongy solid.
Embodiment 4
Taking 3 grams of solid carboxymethyl chitosan dry powder, its deacetylation is 80%, molecular weight is 500,000, adds water 100ml, fully dissolve, be filtered to remove insoluble matter, add glycerol appropriate, it is coated with or is soaked in calcium alginate needle punched non-woven fabrics surface, lyophilization 72 hours, obtaining spongy solid.
Embodiment 5
Take 2 grams of solid carboxymethyl chitosan dry powder, its deacetylation is 85%, molecular weight is 400,000, add water 100ml, fully dissolve, be filtered to remove insoluble matter, add calcium chloride weak solution appropriate, stirring 0.5h is continued after adding glycerol 3-10ml after stirring 1 hour, it is coated with or is soaked in hydrophilic chitosan viscose fiber needle punched non-woven fabrics surface, lyophilization 72 hours, obtaining spongy solid.
Below being only the preferred embodiment of the present invention, it is noted that above-mentioned preferred implementation is not construed as limitation of the present invention, protection scope of the present invention should be as the criterion with claim limited range. For those skilled in the art, without departing from the spirit and scope of the present invention, it is also possible to make some improvements and modifications and also should be regarded as protection scope of the present invention.
Claims (5)
1. a preparation method for composite antibacterial bleeding-stopping dressing, is characterized in that: with chitosan, carboxymethyl chitosan, sodium alginate for raw material, prepare chitosan solution and carboxymethyl chitosan solution; After chitosan solution or carboxymethyl chitosan solution or both solution are added calcium chloride or aldehyde crosslinking agent or plant extract cross-linking agent and betadine antiseptic mixing, the mixed solution of sodium alginate, hyaluronate sodium is added at the solution not forming gel phase, coat fibrous absorbent pad or fabric nonwoven cloth surface, or fibrous absorbent pad or fabric nonwoven cloth be positioned in the solution not forming gel phase be completely soaked to saturated, become spongy solid through vacuum lyophilization.
2. the preparation method of composite antibacterial bleeding-stopping dressing according to claim 1, it is characterized in that: described prepare chitosan solution method be: dissolve the chitosan in acetum or 0.3��4% hydrochloric acid solution or 0.5��8% lactic acid solution or 0.5��10% glutamic acid solution or the compound two kinds sour of 0.5��5%, form the chitosan solution of 0.2��10%.
3. the preparation method of composite antibacterial bleeding-stopping dressing according to claim 1: it is characterized in that: the method for described preparation carboxymethyl chitosan solution is: carboxymethyl chitosan is soluble in water, form the carboxymethyl chitosan solution of 0.2��10%, consider addition betagen solution simultaneously.
4. the preparation method of composite antibacterial bleeding-stopping dressing according to claim 1, the crosslinking of described chitosan is: takes chitosan solution, presses: add glutaraldehyde or other cross-linking agent at 10: 3, and reaction temperature is 25��70 DEG C, mix homogeneously.
5. the preparation method of composite antibacterial bleeding-stopping dressing according to claim 1, the crosslinking of described carboxymethyl chitosan is: go carboxymethyl chitosan solution, add calcium chloride or the crosslinking of other aldehyde crosslinking agent by 10: 2, reaction temperature is 25��50 DEG C, mix homogeneously.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511033800.4A CN105641733A (en) | 2015-12-29 | 2015-12-29 | Preparation method for compound antibacterial haemostatic wound dressing |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511033800.4A CN105641733A (en) | 2015-12-29 | 2015-12-29 | Preparation method for compound antibacterial haemostatic wound dressing |
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| CN105641733A true CN105641733A (en) | 2016-06-08 |
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| CN201511033800.4A Pending CN105641733A (en) | 2015-12-29 | 2015-12-29 | Preparation method for compound antibacterial haemostatic wound dressing |
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Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105999358A (en) * | 2016-07-20 | 2016-10-12 | 广东泰宝医疗科技股份有限公司 | Method for preparing slow-release antibacterial dressing |
| CN107041965A (en) * | 2016-12-26 | 2017-08-15 | 广东海洋大学 | A kind of efficient styptic sponge and preparation method thereof |
| CN108047467A (en) * | 2017-12-12 | 2018-05-18 | 广州昊江新材料有限公司 | Medical cross-linked sponge of chitosan carboxymethyl chitosan and preparation method thereof |
| CN108653798A (en) * | 2018-06-29 | 2018-10-16 | 中山大学附属第医院 | Composition and hemostatic material in medical use for hemostasis |
| CN108822321A (en) * | 2018-07-19 | 2018-11-16 | 佛山皖阳生物科技有限公司 | A kind of preparation method of antibacterial medical collagen membrane |
| CN109010898A (en) * | 2018-09-25 | 2018-12-18 | 温州医科大学 | A kind of chitosan-based gauze dressing of loaded metal ion and preparation method thereof |
| CN109550072A (en) * | 2018-10-18 | 2019-04-02 | 青岛即发集团股份有限公司 | The alginate chitosan composite fiber and its preparation method and application of imbibition swelling |
| CN110184815A (en) * | 2019-04-25 | 2019-08-30 | 扬州纪元纺织有限公司 | A kind of moisturizing antibacterial chitosan filament non-woven fabrics and preparation method thereof |
| CN110787317A (en) * | 2019-10-25 | 2020-02-14 | 重庆医科大学附属永川医院 | Department of anesthesia uses hemostatic sponge |
| CN111514364A (en) * | 2020-03-19 | 2020-08-11 | 中国人民解放军陆军军医大学第二附属医院 | Dressing for perianal infection of patient with malignant hemopathy and preparation method thereof |
| CN112030555A (en) * | 2020-09-16 | 2020-12-04 | 北京健翔嘉业日用品有限责任公司 | Chitosan antibacterial non-woven fabric and preparation method thereof |
| CN112741929A (en) * | 2020-12-28 | 2021-05-04 | 河南亚都实业有限公司 | Medical trauma hemostasis composite dressing |
| CN113144281A (en) * | 2021-04-19 | 2021-07-23 | 深圳市安多福消毒高科技股份有限公司 | Wound surface disinfection gel and preparation method thereof |
| CN113521380A (en) * | 2021-06-30 | 2021-10-22 | 东南大学 | Rapid polymerization hydrogel material and preparation method and application thereof |
| CN114344549A (en) * | 2021-12-13 | 2022-04-15 | 动之医学技术(上海)有限公司 | Composite amnion dressing and preparation method thereof |
| CN115591008A (en) * | 2021-12-31 | 2023-01-13 | 上海炫鑫医药科技有限公司（Cn） | Spray-type liquid wound-protecting dressing and preparation method thereof |
| CN115928416A (en) * | 2023-02-24 | 2023-04-07 | 潍坊医学院附属医院 | Hemostatic gauze and preparation method thereof |
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| CN104436279A (en) * | 2013-09-25 | 2015-03-25 | 山东康力医疗器械科技有限公司 | Preparation method for medical biological antiseptic chitosan dressing |
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2015
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103071181A (en) * | 2013-02-01 | 2013-05-01 | 刘昌桂 | Hydrogel as well as preparation method and purpose of hydrogel |
| CN104436279A (en) * | 2013-09-25 | 2015-03-25 | 山东康力医疗器械科技有限公司 | Preparation method for medical biological antiseptic chitosan dressing |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105999358A (en) * | 2016-07-20 | 2016-10-12 | 广东泰宝医疗科技股份有限公司 | Method for preparing slow-release antibacterial dressing |
| CN107041965A (en) * | 2016-12-26 | 2017-08-15 | 广东海洋大学 | A kind of efficient styptic sponge and preparation method thereof |
| CN108047467A (en) * | 2017-12-12 | 2018-05-18 | 广州昊江新材料有限公司 | Medical cross-linked sponge of chitosan carboxymethyl chitosan and preparation method thereof |
| CN108653798A (en) * | 2018-06-29 | 2018-10-16 | 中山大学附属第医院 | Composition and hemostatic material in medical use for hemostasis |
| CN108822321A (en) * | 2018-07-19 | 2018-11-16 | 佛山皖阳生物科技有限公司 | A kind of preparation method of antibacterial medical collagen membrane |
| CN109010898B (en) * | 2018-09-25 | 2021-07-20 | 温州医科大学 | Metal ion loaded chitosan-based gauze dressing and preparation method thereof |
| CN109010898A (en) * | 2018-09-25 | 2018-12-18 | 温州医科大学 | A kind of chitosan-based gauze dressing of loaded metal ion and preparation method thereof |
| CN109550072A (en) * | 2018-10-18 | 2019-04-02 | 青岛即发集团股份有限公司 | The alginate chitosan composite fiber and its preparation method and application of imbibition swelling |
| CN110184815A (en) * | 2019-04-25 | 2019-08-30 | 扬州纪元纺织有限公司 | A kind of moisturizing antibacterial chitosan filament non-woven fabrics and preparation method thereof |
| CN110787317A (en) * | 2019-10-25 | 2020-02-14 | 重庆医科大学附属永川医院 | Department of anesthesia uses hemostatic sponge |
| CN111514364A (en) * | 2020-03-19 | 2020-08-11 | 中国人民解放军陆军军医大学第二附属医院 | Dressing for perianal infection of patient with malignant hemopathy and preparation method thereof |
| CN112030555A (en) * | 2020-09-16 | 2020-12-04 | 北京健翔嘉业日用品有限责任公司 | Chitosan antibacterial non-woven fabric and preparation method thereof |
| CN112741929A (en) * | 2020-12-28 | 2021-05-04 | 河南亚都实业有限公司 | Medical trauma hemostasis composite dressing |
| CN113144281A (en) * | 2021-04-19 | 2021-07-23 | 深圳市安多福消毒高科技股份有限公司 | Wound surface disinfection gel and preparation method thereof |
| CN113521380A (en) * | 2021-06-30 | 2021-10-22 | 东南大学 | Rapid polymerization hydrogel material and preparation method and application thereof |
| CN114344549A (en) * | 2021-12-13 | 2022-04-15 | 动之医学技术(上海)有限公司 | Composite amnion dressing and preparation method thereof |
| CN115591008A (en) * | 2021-12-31 | 2023-01-13 | 上海炫鑫医药科技有限公司（Cn） | Spray-type liquid wound-protecting dressing and preparation method thereof |
| CN115928416A (en) * | 2023-02-24 | 2023-04-07 | 潍坊医学院附属医院 | Hemostatic gauze and preparation method thereof |
| CN115928416B (en) * | 2023-02-24 | 2023-04-28 | 潍坊医学院附属医院 | Hemostatic gauze and preparation method thereof |
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Application publication date: 20160608 |
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