CN104436279A - Preparation method for medical biological antiseptic chitosan dressing - Google Patents
Preparation method for medical biological antiseptic chitosan dressing Download PDFInfo
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- CN104436279A CN104436279A CN201310463753.1A CN201310463753A CN104436279A CN 104436279 A CN104436279 A CN 104436279A CN 201310463753 A CN201310463753 A CN 201310463753A CN 104436279 A CN104436279 A CN 104436279A
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Abstract
The invention relates to a preparation method for a medical biological antiseptic chitosan dressing which comprises the main ingredients of chitin, chitosan, carboxymethyl chitosan, viscose fibres and the like, and the auxiliary materials of formaldehyde, glutaraldehyde, calcium chloride, glycerinum and the like. The preparation method comprises the following steps: forming a gel from chitosan solution or carboxymethyl chitosan solution or both chitosan solution and carboxymethyl chitosan solution after being crosslinked by a calcium chloride crosslinking agent or an aldehyde crosslinking agent, then coating or soaking the gel on the surface of a fibre water-absorbent pad or a chitosan acupuncture non-woven fabric or a chitin acupuncture non-woven fabric or a hydrophilic chitosan viscose fibre acupuncture non-woven fabric, and forming a spongy solid through vacuum freeze-drying. The product is independent of the conventional clotting mechanism, has a quite strong hemostatic effect, does not influence the functions and the number of blood platelets, and avoids the formation of thrombus; the medical biological antiseptic chitosan dressing has an antibiotic barrier function and the advantages of being infection-preventing, water-absorbent and easy to remove.
Description
Technical field:
The present invention relates to a kind of preparation method of medical bio antiseptic dressing, especially a kind of preparation method of chitosan medical biological antibacterial dressing.
Background technology:
Antibacterial anti hemorrhagic is the problem that hospital surgical often runs into always, is also the difficult problem that daily life often runs into.Medical dressing is that a class carries out the interim medical material covered for various wound, wound surface, and it can make wound exempt from the impact of bacteriological infection and other foeign elements, plays the effect of protection wound, wound surface.Chitin is the natural macromolecular material extracted from the cell wall of the shell of the Crustacean such as shrimp, Eriocheir sinensis and bacterium, algae rudimentary plant, is that occurring in nature is only second to cellulosic second largest biologically-derived resource.Chitosan is the product of de-acetyl chitin, is the unique alkaline polysaccharide of occurring in nature.In general, the N-acetyl group of chitin is sloughed more than 50% and just can be called chitosan.Chitosan is the high molecular polysaccharose substance of a kind of pure natural, and the toxicity research of chitosan shows, chitosan is substantially nontoxic, has good safety, good biocompatibility, and can degraded and absorbed.In addition, chitosan can also suppress the effect of various bacteria and conk.Owing to having the physiologically active of uniqueness and excellence, the application of chitosan in wound dressing become gradually its biomaterial application in a focus.
Summary of the invention:
The object of this invention is to provide one there is bacteria growing inhibiting, stop antibacterial to enter wound surface, promote skin regeneration, healing acceleration, reduce the preparation method of the chitosan medical biological antibacterial dressing of the advantage such as cicatrix.
For achieving the above object, the technical solution used in the present invention is:
A preparation method for chitosan medical biological antibacterial dressing, is made up of the following step:
1, the preparation of chitosan solution, is dissolved in the acetum of 0.5 ~ 5%, 0.3 ~ 4% hydrochloric acid solution or 0.5 ~ 8% lactic acid solution or 0.5 ~ 10% glutamic acid solution or two kinds of sour compounds, forms the chitosan solution of 0.2 ~ 10% by chitosan.
2, the preparation of carboxymethyl chitosan solution: carboxymethyl chitosan is soluble in water, forms the carboxymethyl chitosan solution of 0.2 ~ 10%.
3, chitosan is crosslinked: get chitosan solution, add glutaraldehyde or other cross-linking agent by a certain percentage, reaction temperature is 25 ~ 70 DEG C, and the response time is 2 ~ 8 hours.
4, carboxymethyl chitosan is crosslinked: go carboxymethyl chitosan solution, adds calcium chloride by a certain percentage or other aldehyde crosslinking agent are cross-linked, and reaction temperature is 25 ~ 50 DEG C, and the response time is 1 ~ 8 hour.
5, the solution prepared by step 1 ~ 4 and crosslinked rear gel, coating or be soaked in fibrous absorbent pad or chitosan needle punched non-woven fabrics or hydrophilic chitin needle punched non-woven fabrics or hydrophilic chitosan viscose fiber needle punched non-woven fabrics surface, becomes spongy solid through vacuum lyophilization.
The invention has the beneficial effects as follows: chitosan medical biological antibacterial dressing prepared by Using such method is nontoxic, and without thermal source, biocompatibility is high; There is bacteria growing inhibiting, stop antibacterial to enter wound surface, promote skin regeneration, healing acceleration, reduce the advantages such as cicatrix.
Detailed description of the invention:
Below in conjunction with specific embodiment, the present invention will be further described, but the present invention not limited by following examples.
Embodiment 1
Get 5 grams, solid chitosan dry powder, its deacetylation is 75%, molecular weight is 300,000, add the acetum 100ml of 2%, abundant dissolving, cross and filter insoluble matter, add glycerol in right amount, coat chitosan needle punched non-woven fabrics surface or non-woven fabrics is soaked in solution, lyophilization 72 hours, obtains spongy solid.
Embodiment 2
Get 3 grams, solid chitosan dry powder, its deacetylation is 85%, molecular weight is 350,000, add the acetum 100ml of 2%, fully dissolve, cross and filter insoluble matter, add glutaraldehyde weak solution, add glycerol 3-10ml after 1 ~ 3 hour, coreaction 6 hours at 25 DEG C, coat chitosan needle punched non-woven fabrics surface or non-woven fabrics is soaked in solution, lyophilization 72 hours, obtains spongy solid.
Embodiment 3
Get 4 grams, solid chitosan dry powder, its deacetylation is 80%, molecular weight is 400,000, add the acetum 100ml of 2%, fully dissolve, cross and filter insoluble matter, add formaldehyde weak solution, add glycerol 3-10ml after 1 ~ 3 hour, coreaction 7 hours at 25 DEG C, coat chitosan needle punched non-woven fabrics surface or non-woven fabrics is soaked in solution, lyophilization 72 hours, obtains spongy solid.
Embodiment 4
Get 3 grams, solid carboxymethyl chitosan dry powder, its deacetylation is 80%, molecular weight is 500,000, add water 100ml, abundant dissolving, cross and filter insoluble matter, add glycerol in right amount, coat chitosan needle punched non-woven fabrics surface or non-woven fabrics is soaked in solution, lyophilization 72 hours, obtains spongy solid.
Embodiment 5
Get 2 grams, solid carboxymethyl chitosan dry powder, its deacetylation is 85%, molecular weight is 400,000, add water 100ml, fully dissolve, cross and filter insoluble matter, add calcium chloride weak solution appropriate, add glycerol 3-10ml after 1 ~ 3 hour, coreaction 5 hours at 30 DEG C, coat chitosan needle punched non-woven fabrics surface or non-woven fabrics is soaked in solution, lyophilization 72 hours, obtains spongy solid.
The preparation method of above embodiment is identical, and concrete operation step is as follows:
1, the preparation of chitosan solution, is dissolved in the acetum of 0.5 ~ 5%, 0.3 ~ 4% hydrochloric acid solution or 0.5 ~ 8% lactic acid solution or 0.5 ~ 10% glutamic acid solution or two kinds of sour compounds, forms the chitosan solution of 0.2 ~ 10% by chitosan.
2, the preparation of carboxymethyl chitosan solution: carboxymethyl chitosan is soluble in water, forms the carboxymethyl chitosan solution of 0.2 ~ 10%.
3, chitosan is crosslinked: get chitosan solution, add glutaraldehyde or other cross-linking agent by a certain percentage, reaction temperature is 25 ~ 70 DEG C, and the response time is 2 ~ 8 hours.
4, carboxymethyl chitosan is crosslinked: go carboxymethyl chitosan solution, adds calcium chloride by a certain percentage or other aldehyde crosslinking agent are cross-linked, and reaction temperature is 25 ~ 50 DEG C, and the response time is 1 ~ 8 hour.
5, the solution prepared by step 1 ~ 4 and crosslinked rear gel, coating or be soaked in fibrous absorbent pad or chitosan needle punched non-woven fabrics or hydrophilic chitin needle punched non-woven fabrics or hydrophilic chitosan viscose fiber needle punched non-woven fabrics surface, becomes spongy solid through vacuum lyophilization.
Claims (1)
1. a preparation method for chitosan medical biological antibacterial dressing, is made up of the following step:
(1) preparation of chitosan solution, is dissolved in the acetum of 0.5 ~ 5%, 0.3 ~ 4% hydrochloric acid solution or 0.5 ~ 8% lactic acid solution or 0.5 ~ 10% glutamic acid solution or two kinds of sour compounds, forms the chitosan solution of 0.2 ~ 10% by chitosan;
(2) preparation of carboxymethyl chitosan solution: carboxymethyl chitosan is soluble in water, forms the carboxymethyl chitosan solution of 0.2 ~ 10%;
(3) chitosan is crosslinked: get chitosan solution, add glutaraldehyde or other cross-linking agent by a certain percentage, reaction temperature is 25 ~ 70 DEG C, and the response time is 2 ~ 8 hours;
(4) carboxymethyl chitosan is crosslinked: go carboxymethyl chitosan solution, adds calcium chloride by a certain percentage or other aldehyde crosslinking agent are cross-linked, and reaction temperature is 25 ~ 50 DEG C, and the response time is 1 ~ 8 hour;
(5) solution prepared by step 1 ~ 4 and crosslinked rear gel, coating or be soaked in fibrous absorbent pad or chitosan needle punched non-woven fabrics or hydrophilic chitin needle punched non-woven fabrics or hydrophilic chitosan viscose fiber needle punched non-woven fabrics surface, becomes spongy solid through vacuum lyophilization.
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| CN201310463753.1A CN104436279A (en) | 2013-09-25 | 2013-09-25 | Preparation method for medical biological antiseptic chitosan dressing |
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| CN201310463753.1A CN104436279A (en) | 2013-09-25 | 2013-09-25 | Preparation method for medical biological antiseptic chitosan dressing |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641733A (en) * | 2015-12-29 | 2016-06-08 | 山东康力医疗器械科技有限公司 | Preparation method for compound antibacterial haemostatic wound dressing |
| CN107198790A (en) * | 2017-05-25 | 2017-09-26 | 李美英 | A kind of degradable dressing of animal doctor's antibiotic-free |
| CN107693213A (en) * | 2017-11-06 | 2018-02-16 | 侯强 | A kind of degradable dressing for Wound-surface negative pressure treatment |
| CN108047467A (en) * | 2017-12-12 | 2018-05-18 | 广州昊江新材料有限公司 | Medical cross-linked sponge of chitosan carboxymethyl chitosan and preparation method thereof |
| CN108691206A (en) * | 2018-04-26 | 2018-10-23 | 东华大学 | A kind of preparation method of ultralight high-strength chitin fiber fabric |
| CN110947023A (en) * | 2019-12-09 | 2020-04-03 | 中国科学院海洋研究所 | Preparation for improving antibacterial performance of sanitary cotton and antibacterial method thereof |
| CN113304302A (en) * | 2021-05-25 | 2021-08-27 | 南通大学 | Anti-adhesion medical dressing for promoting healing of high-exudative wound and preparation method thereof |
| CN114469527A (en) * | 2022-01-04 | 2022-05-13 | 奥美佰玛(武汉)生物科技有限公司 | Nerve surgical tablet with low floc and high moisture absorption and preparation method thereof |
| CN116463848A (en) * | 2023-03-15 | 2023-07-21 | 南通大学 | Preparation method of super-absorbent antibacterial viscose medical dressing |
-
2013
- 2013-09-25 CN CN201310463753.1A patent/CN104436279A/en not_active Withdrawn
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641733A (en) * | 2015-12-29 | 2016-06-08 | 山东康力医疗器械科技有限公司 | Preparation method for compound antibacterial haemostatic wound dressing |
| CN107198790A (en) * | 2017-05-25 | 2017-09-26 | 李美英 | A kind of degradable dressing of animal doctor's antibiotic-free |
| CN107693213A (en) * | 2017-11-06 | 2018-02-16 | 侯强 | A kind of degradable dressing for Wound-surface negative pressure treatment |
| CN107693213B (en) * | 2017-11-06 | 2024-04-30 | 侯强 | Degradable dressing for wound negative pressure treatment |
| CN108047467A (en) * | 2017-12-12 | 2018-05-18 | 广州昊江新材料有限公司 | Medical cross-linked sponge of chitosan carboxymethyl chitosan and preparation method thereof |
| CN108691206A (en) * | 2018-04-26 | 2018-10-23 | 东华大学 | A kind of preparation method of ultralight high-strength chitin fiber fabric |
| CN110947023A (en) * | 2019-12-09 | 2020-04-03 | 中国科学院海洋研究所 | Preparation for improving antibacterial performance of sanitary cotton and antibacterial method thereof |
| CN113304302A (en) * | 2021-05-25 | 2021-08-27 | 南通大学 | Anti-adhesion medical dressing for promoting healing of high-exudative wound and preparation method thereof |
| CN114469527A (en) * | 2022-01-04 | 2022-05-13 | 奥美佰玛(武汉)生物科技有限公司 | Nerve surgical tablet with low floc and high moisture absorption and preparation method thereof |
| CN116463848A (en) * | 2023-03-15 | 2023-07-21 | 南通大学 | Preparation method of super-absorbent antibacterial viscose medical dressing |
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Application publication date: 20150325 |