CN110947023A - Preparation for improving antibacterial performance of sanitary cotton and antibacterial method thereof - Google Patents
Preparation for improving antibacterial performance of sanitary cotton and antibacterial method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
Abstract
The invention belongs to the technical processing and application field of marine resource natural products, and particularly relates to a preparation for improving antibacterial performance of sanitary cotton and an antibacterial method thereof. The preparation comprises main materials; or, the main material is chitosan and the auxiliary material is fish collagen or fish collagen and glycerol; the molecular weight of the chitosan is 10-2000 KDa, and the deacetylation degree is 80-100%. The preparation has the advantages of low price, small dosage, safety, convenience, no toxic or side effect and small influence on the product cost, greatly improves the antibacterial performance of the sanitary napkin, and does not change the original absorption performance and flexibility of the sanitary napkin.
Description
Technical Field
The invention belongs to the technical processing and application field of marine resource natural products, and particularly relates to a preparation for improving antibacterial performance of sanitary cotton and an antibacterial method thereof.
Background
Candida albicans is also called Candida albicans and Candida albicans. The candida is one of the candida, generally exists in the oral cavity, the upper respiratory tract, the intestinal tract and the vagina of a normal person, is generally small in quantity in a normal body, does not cause diseases, and is propagated in large quantity and invaded into cells to cause diseases in a changed growth form (budding hypha phase) when the immune function or general defense capacity of the body is reduced or the mutual restriction and interaction of normal flora are disordered. If the candida albicans is proliferated in the vagina in a large quantity, vaginitis can be caused.
Chitosan, as a deacetylation product of natural polysaccharide chitin, has a number of excellent physicochemical properties, such as biocompatibility, biodegradability, non-toxicity, multi-reactivity, low irritation, broad-spectrum antibacterial properties, and the like. Chitosan has been found for over a hundred years and is now widely used in textile, paper, food, pharmaceutical and chemical industries.
A great number of documents report that chitosan has broad-spectrum antibacterial performance and has better inhibitory effect on various bacteria, fungi and even some viruses. The chitosan film formed by dissolving chitosan in acetic acid and drying has good antibacterial effect, but the film is large in brittleness and waterproof, if the chitosan film is coated on the surface of the sanitary napkin, the flexibility and the absorptivity of the sanitary napkin can be seriously influenced, and the due functions of the sanitary napkin can be damaged while the antibacterial performance of the sanitary napkin is improved. Therefore, the premise of improving the antibacterial performance of the sanitary napkin by utilizing the chitosan is to maintain the absorbency and flexibility of the sanitary napkin.
Disclosure of Invention
The invention aims to provide a preparation for improving the antibacterial performance of sanitary cotton and an antibacterial method thereof.
In order to achieve the purpose, the invention adopts the technical scheme that:
a preparation for improving antibacterial property of sanitary cotton comprises main materials; or, the main material is chitosan and the auxiliary material is fish collagen or fish collagen and glycerol; the molecular weight of the chitosan is 10-2000 KDa, and the deacetylation degree is 80-100%.
Further, the main material is chitosan acetic acid solution, wherein the ratio of chitosan to water is 1:100-1000 (w/v); the ratio of acetic acid to water is 1:100-1000 (v/v); the ratio of chitosan to acetic acid is 1-5:1 (w/v).
Still further, the fish collagen in the auxiliary material is a fish collagen acetic acid solution, wherein in the fish collagen acetic acid solution, the ratio of the fish collagen to water is 1:1000-10000 (w/v); the ratio of acetic acid to water is 1:1000-10000 (v/v); the ratio of fish collagen to acetic acid is 1:1-5 (w/v).
The preparation is chitosan acetic acid solution and fish collagen acetic acid solution; or chitosan acetic acid solution, fish collagen acetic acid solution and glycerol;
wherein, the chitosan acetic acid solution is added with the fish collagen acetic acid solution with the volume of 0-10% (v/v); the addition amount of glycerol is 0-10% of the total volume of chitosan acetic acid solution and fish collagen acetic acid solution.
The application of a preparation for improving the bacteriostatic property of sanitary cotton is to the application of the preparation as a bacteriostatic agent of the sanitary cotton.
When the preparation is a chitosan acetic acid solution, the preparation is a chitosan acetic acid solution and a fish collagen acetic acid solution, the preparation is added into the sanitary napkin respectively in an injection mode;
or the preparation is chitosan acetic acid solution and fish collagen acetic acid solution; or, adding chitosan acetic acid solution, fish collagen acetic acid solution and glycerol into sanitary napkin by injection, soaking or spraying.
A sanitary napkin with improved antibacterial performance:
adding 0-10% (v/v) fish collagen acetic acid solution into chitosan acetic acid solution, stirring in 40 deg.C constant temperature water bath for 20-60 min, and cooling to room temperature;
adding glycerol with the volume of 0-10% (v/v) into the liquid cooled to room temperature, uniformly stirring, and ultrasonically degassing for 20-60 minutes to form the chitosan preparation as claimed in claim 1;
the liquid chitosan formulation was added to the sanitary napkin.
Adding the liquid chitosan preparation into the sanitary napkin by soaking, spraying or injecting; the preparation is added in a soaking mode, and the adding amount of the preparation needs to cover the surface of the sanitary napkin; the preparation is added in a spraying mode, and the addition amount of the preparation needs to cover the surface of the sanitary napkin; the preparation is added in an injection mode, and the adding amount of the preparation is 10-100% (v/v) of the maximum absorption capacity of the sanitary napkin.
The sanitary napkin added with the chitosan preparation is dried for 24 hours at 50 ℃, and then is placed at room temperature to obtain the sanitary napkin with obviously enhanced antibacterial performance.
The invention has the advantages of
1. The invention adopts chitosan as a main material to prepare the sanitary napkin bacteriostatic agent for improving the bacteriostatic performance of the sanitary napkin, and finds that the method can obviously improve the inhibitory action of the sanitary napkin on candida albicans and can play a good role in preventing and treating vaginitis. The chitosan is natural and nontoxic, and has good application prospect when being used for developing antibacterial products of sanitary cotton.
2. The collagen derived from marine animals is obviously superior to the collagen derived from terrestrial animals in some aspects, such as low antigenicity, low allergy and the like. The type I collagen contained in the fish skin is the main collagen, the price is proper, the cost is not increased greatly by adding the formula for improving the sanitary napkin antibacterial agent, the price floating is low, and the fish skin is easy to accept by people. The collagen has very strong extension force and good water-retaining property, and researches show that after the fish collagen is added into the chitosan and attached to the sanitary napkin to form a film, the film is not easy to break and the absorption capacity of the sanitary napkin can be maintained.
3. Glycerol is a softening agent, a moisture absorbent, an anti-wrinkle agent, a diffusing agent and a penetrating agent. The research of this patent finds that can prevent to make the cotton wool shrink after the solution is dry after adding glycerine in chitosan acetic acid solution, the sclerosis to promote the infiltration and the diffusion of chitosan in the cotton wool, ensure its antibacterial performance and exert well.
4. The proportion of the main material and the auxiliary material is proper, so that the balance of microecology in the vagina is not destroyed while the antibacterial performance of the sanitary napkin is ensured to be improved.
Drawings
FIG. 1 is a graph showing the effect of adding chitosan preparation to a sanitary napkin according to an embodiment of the present invention by soaking in water on the growth of Candida albicans; wherein A is not added, and B is added chitosan preparation.
FIG. 2 is a graph showing the effect of adding chitosan preparation to the sanitary napkin of the present invention by soaking to inhibit the growth of Candida albicans; wherein A is not added, and B is added chitosan preparation.
Detailed Description
The present invention is further illustrated below, and the scope of protection of the present invention is not limited to the following examples.
The inhibitor of the invention is prepared by adding auxiliary materials of fish collagen and glycerol into chitosan. The collagen is safe, non-toxic and non-irritant, and can be used as a carrier of a bacteriostatic agent to be applied to a plurality of fields; meanwhile, the collagen derived from marine animals has the characteristics of low antigenicity, low allergy and the like; furthermore, the type I collagen contained in the fish skin is the main collagen. The collagen has strong extension force and good water retention, and the absorption and flexibility of the sanitary napkin can be maintained by adding the fish collagen into the chitosan and attaching the chitosan to the sanitary napkin; in addition, the glycerin is a softening agent, a moisture absorbent, an anti-crease treatment agent, a dispersing agent and a penetrating agent, and is non-toxic and non-irritant. The glycerol is added into the chitosan acetic acid solution, so that the sanitary napkin is prevented from shrinking and hardening after the solution is dried, the permeation and diffusion of the chitosan in the sanitary napkin are promoted, and the good antibacterial performance of the sanitary napkin is ensured.
According to the invention, the chitosan preparation is added into the sanitary napkin, and the antibacterial activity of chitosan, the extensibility, the water retention and the multiple characteristics of glycerol are utilized, so that the sanitary napkin does not lose flexibility and absorptivity while the antibacterial performance is enhanced, the normal performance of the sanitary napkin is ensured, and the antibacterial performance is improved.
Example 1
Weighing 1g of chitosan with molecular weight of 2000KDa and deacetylation degree of 85%, adding 200ml of water and 0.5ml of acetic acid, and stirring uniformly to obtain chitosan acetic acid solution.
Weighing 1g of fish collagen, adding 200ml of water and 1ml of acetic acid, and uniformly stirring to obtain the fish collagen acetic acid solution.
Adding 10% (v/v) fish collagen acetic acid solution into chitosan acetic acid solution, stirring in 40 deg.C constant temperature water bath for 30 min, and cooling to room temperature.
Adding glycerol with the volume of 10% (v/v) into the liquid cooled to room temperature, stirring uniformly, and ultrasonically degassing for 40 minutes to form the liquid chitosan preparation.
Adding the liquid chitosan preparation into the sanitary napkin in a soaking mode, so that the surface of the sanitary napkin is covered with the chitosan preparation, and draining the redundant chitosan liquid on the surface of the sanitary napkin.
Drying the sanitary napkin added with the chitosan preparation at 50 ℃ for 24 hours, and then placing the sanitary napkin at room temperature to obtain the sanitary napkin covered with the chitosan preparation.
Common sanitary napkins and sanitary napkins coated with chitosan preparations obtained in the examples are respectively immersed in a candida albicans suspension, taken out after 3 seconds, drained of excessive moisture, packaged by a sealing bag, placed in a constant-temperature incubator at 37 ℃ for culturing for 24 hours, and the growth conditions of the candida albicans on the three sanitary napkins and the absorption performance of the sanitary napkins are observed in a contrast manner, so that the growth conditions of the candida albicans are good on the sanitary napkins without the chitosan preparation, while the growth of the candida albicans is obviously inhibited on the sanitary napkins with the chitosan preparation and the chitosan acetic acid solution (shown in figure 1), wherein the absorption performance of the sanitary napkins with the chitosan preparation is equivalent to the calibrated absorption performance (shown in figure 1), and the absorption performance of the sanitary napkins with the chitosan acetic acid solution is obviously inhibited (shown in figure 2).
Candida albicans was purchased from a Chinese microbial species query network (number: CMCC98001), and the culture information was found in websites: http:// www.biobw.org/China-string/bio-52835. html
TABLE 1 maximum absorbent Capacity of sanitary napkin
Example 2
Weighing 1g of chitosan with the molecular weight of 1500KDa and the deacetylation degree of 80%, adding 500ml of water and 1ml of acetic acid, and uniformly stirring to obtain a chitosan acetic acid solution.
Weighing 1g of fish collagen, adding 500ml of water and 1ml of acetic acid, and uniformly stirring to obtain the fish collagen acetic acid solution.
Adding 5% (v/v) fish collagen acetic acid solution into chitosan acetic acid solution, stirring in 40 deg.C constant temperature water bath for 20 min, and cooling to room temperature.
Adding glycerol with the volume of 5% (v/v) into the liquid cooled to room temperature, stirring uniformly, and ultrasonically degassing for 30 minutes to form the liquid chitosan preparation.
Adding the liquid chitosan preparation into the sanitary napkin by spraying, so that the surface of the sanitary napkin is covered with the chitosan preparation, and draining the redundant chitosan liquid on the surface of the sanitary napkin.
Drying the sanitary napkin added with the chitosan preparation at 50 ℃ for 24 hours, and then placing the sanitary napkin at room temperature to obtain the sanitary napkin covered with the chitosan preparation.
Common sanitary napkins and sanitary napkins covered with chitosan preparations are respectively immersed in the candida albicans suspension, taken out after 3 seconds, drained of excessive moisture, packaged by a sealing bag, placed in a constant-temperature incubator at 37 ℃ for culturing for 24 hours, the measured pH value is 4.0, the growth conditions of the candida albicans on the two sanitary napkins and the absorption performance of the sanitary napkins are compared and observed, the growth conditions of the candida albicans are found to be good on the sanitary napkins without the chitosan preparation, the growth of the candida albicans is obviously inhibited on the sanitary napkins with the chitosan preparation (shown in figure 2), the candida albicans is purchased from a Chinese microbial strain inquiry net (number: CMCC98001), and the culture information is shown in a website: http:// www.biobw.org/China-string/bio-52835. html
In conclusion, the chitosan preparation is added in a certain proportion in the processes of preparation and addition of the chitosan preparation to the sanitary napkin, so that the bacteriostatic effect is achieved, and meanwhile, the vaginal microecological balance, the flexibility and the absorptivity of the sanitary napkin are not damaged; and a certain pH value (the normal pH value of the vagina is 3.8-4.5, and the most suitable pH value for the growth of candida albicans is 6.2 +/-0.2) is maintained, so that the bacteriostatic performance of the sanitary napkin is improved.
Example 3
Weighing 1g of chitosan with the molecular weight of 68.6KDa and the deacetylation degree of 85%, adding 200ml of water and 0.5ml of acetic acid, and uniformly stirring to obtain a chitosan acetic acid solution.
Adding chitosan acetic acid solution into sanitary napkin by soaking, injecting or spraying to make the surface of sanitary napkin covered with chitosan preparation, and draining off excessive chitosan liquid on the surface of sanitary napkin.
Drying the sanitary napkin added with the chitosan acetic acid solution at 50 ℃ for 24 hours, and then placing the sanitary napkin at room temperature to obtain the sanitary napkin covered with the chitosan acetic acid solution.
The chitosan preparation obtained in the above example 1 and the chitosan acetic acid solution were added to the sanitary napkin by soaking, spraying and injecting, the soaking mode: the addition amount covers the surface of the sanitary napkin, and the spraying mode is as follows: the addition amount covers the surface of the sanitary napkin, and the injection mode is as follows: the amount added was 3 ml.
Maximum absorbent capacity of the tampon was 12 ml.
Drying the sanitary napkin added with the chitosan preparation or the chitosan acetic acid solution at 50 ℃ for 24 hours, and then cooling to room temperature to obtain the sanitary napkin containing the chitosan preparation or the chitosan acetic acid solution. The absorption properties of the 6 types of sanitary napkins were examined.
TABLE 2 maximum absorbent Capacity of the sanitary napkin
As can be seen from Table 2, the absorption performance of the sanitary napkin is seriously affected by adding the chitosan acetic acid solution to the sanitary napkin in a spraying or soaking mode, and after the chitosan acetic acid solution is added with the fish collagen and the glycerol to prepare the chitosan preparation, the absorption performance of the sanitary napkin is not affected no matter the chitosan preparation is added to the sanitary napkin in a soaking, spraying or injecting mode, and the bacteriostatic action of the chitosan is kept.
Claims (9)
1. A preparation for improving antibacterial performance of sanitary cotton is characterized in that: the preparation comprises main materials; or, the main material is chitosan and the auxiliary material is fish collagen or fish collagen and glycerol; the molecular weight of the chitosan is 10-2000 KDa, and the deacetylation degree is 80-100%.
2. The preparation for improving the bacteriostatic property of the sanitary napkin according to claim 1, wherein: the main material is chitosan acetic acid solution, wherein the ratio of chitosan to water is 1:100-1000 (w/v); the ratio of acetic acid to water is 1:100-1000 (v/v); the ratio of chitosan to acetic acid is 1-5:1 (w/v).
3. The preparation for improving the bacteriostatic property of the sanitary napkin according to claim 1, wherein:
the fish collagen in the auxiliary material is fish collagen acetic acid solution, wherein in the fish collagen acetic acid solution, the ratio of the fish collagen to water is 1:1000-10000 (w/v); the ratio of acetic acid to water is 1:1000-10000 (v/v); the ratio of fish collagen to acetic acid is 1:1-5 (w/v).
4. The formulation for enhancing the bacteriostatic properties of a sanitary napkin according to any one of claims 1 to 3, wherein: the preparation is chitosan acetic acid solution and fish collagen acetic acid solution; or chitosan acetic acid solution, fish collagen acetic acid solution and glycerol;
wherein, the chitosan acetic acid solution is added with the fish collagen acetic acid solution with the volume of 0-10% (v/v); the addition amount of glycerol is 0-10% of the total volume of chitosan acetic acid solution and fish collagen acetic acid solution.
5. The use of the preparation for improving the bacteriostatic property of the sanitary napkin according to claim 1, wherein the preparation comprises the following components: the preparation is applied to the application of the sanitary cotton as a bacteriostatic agent.
6. The use of the formulation of claim 5 for enhancing the bacteriostatic properties of a sanitary napkin, wherein: when the preparation is a chitosan acetic acid solution, the preparation is a chitosan acetic acid solution and a fish collagen acetic acid solution, the preparation is added into the sanitary napkin respectively in an injection mode;
or the preparation is chitosan acetic acid solution and fish collagen acetic acid solution; or, adding chitosan acetic acid solution, fish collagen acetic acid solution and glycerol into sanitary napkin by injection, soaking or spraying.
7. The utility model provides an improve sanitary-napkin of antibacterial performance which characterized in that:
adding 0-10% (v/v) fish collagen acetic acid solution into chitosan acetic acid solution, stirring in 40 deg.C constant temperature water bath for 20-60 min, and cooling to room temperature;
adding glycerol with the volume of 0-10% (v/v) into the liquid cooled to room temperature, uniformly stirring, and ultrasonically degassing for 20-60 minutes to form the chitosan preparation as claimed in claim 1;
the liquid chitosan formulation was added to the sanitary napkin.
8. The tampon of claim 7, wherein: adding the liquid chitosan preparation into the sanitary napkin by soaking, spraying or injecting; the preparation is added in a soaking mode, and the adding amount of the preparation needs to cover the surface of the sanitary napkin; the preparation is added in a spraying mode, and the addition amount of the preparation needs to cover the surface of the sanitary napkin; the preparation is added in an injection mode, and the adding amount of the preparation is 10-100% (v/v) of the maximum absorption capacity of the sanitary napkin.
9. The sanitary napkin with improved antibacterial properties according to claim 7 or 8, wherein: the sanitary napkin added with the chitosan preparation is dried for 24 hours at 50 ℃, and then is placed at room temperature to obtain the sanitary napkin with obviously enhanced antibacterial performance.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112353999A (en) * | 2020-11-11 | 2021-02-12 | 湖南旺旺医院有限公司 | Perineum pad for obstetrics and preparation method thereof |
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