CN108653798A - Composition and hemostatic material in medical use for hemostasis - Google Patents
Composition and hemostatic material in medical use for hemostasis Download PDFInfo
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- CN108653798A CN108653798A CN201810712223.9A CN201810712223A CN108653798A CN 108653798 A CN108653798 A CN 108653798A CN 201810712223 A CN201810712223 A CN 201810712223A CN 108653798 A CN108653798 A CN 108653798A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/102—Collagen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0031—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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Abstract
The invention discloses a kind of compositions and hemostatic material in medical use for hemostasis, and the composition includes the raw material of following parts by weight：10~20 parts of 15~25 parts of collagen, 20~30 parts of chitosan, 1~5 part of gel-type vehicle, 10~20 parts of nano-silver powder and hemostasis Chinese herbal extract.The present invention makes full use of the Action advantages of ingredients such as collagen, chitosan, nano-silver powder and hemostasis Chinese herbal extract and mutually synergistic effect, make the hemostatic material in medical use being prepared, have many advantages, such as that anthemorrhagic speed is fast, haemostatic effect is good, being capable of effective antibacterial bacteriostatic and good biocompatibility, composition and hemostatic material in medical use for hemostasis of the invention simultaneously is to human body without Du's side effect, it is safe to use to skin without any stimulation.
Description
Technical field
The present invention relates to technical field of biomedical materials, in particular to a kind of composition for hemostasis and doctor
Use hemostatic material.
Background technology
In general, normal in blood of human body itself coagulation function, general tissue injury can with self-regeneration,
Epidermis bleeding or phleborrhagia can self-solidifyings.However, arterial hamorrhage, larger phleborrhagia, more serious tissue injury or big
Blood can not reach the machine of self-protection from coalescence in time when the surgical procedures of majority, such as take measures not in time, will
Lead to serious bleeding, excessive often threat to life of losing blood.Especially afield, field burst accident, earthquake class are natural
It is particularly important using fast and effectively hemostatic material in the case of disaster, surgical operation etc. are various.
However, traditional hemostatic material such as tourniquet function and single effect, antibacterial effect is poor, and haemostatic effect is not good enough, only
Blood speed is slow.
Invention content
In view of this, a kind of composition and hemostatic material in medical use for hemostasis provided by the invention, preferably overcomes
The above-mentioned problems of the prior art and defect utilize collagen, chitosan, nano-silver powder and hemostasis Chinese herbal extract etc.
The Action advantage of ingredient and mutually synergistic effect, make the hemostatic material in medical use being prepared, the fast, haemostatic effect with anthemorrhagic speed
It is good, can effective bactericidal and the advantages that good biocompatibility, while the present invention for the composition of hemostasis and medical
Hemostatic material to human body without Du side effect, it is safe to use to skin without any stimulation.
A kind of composition for hemostasis includes the raw material of following parts by weight：15~25 parts of collagen, chitosan 20
10~20 parts of~30 parts, 1~5 part of gel-type vehicle, 10~20 parts of nano-silver powder and hemostasis Chinese herbal extract.
Further, the composition further includes the raw material of following parts by weight：1~5 part of Lasiosphaera fenzlii conidia powder.
Further, the collagen is Isin glue collagen.
Further, the chitosan is water soluble chitosan, and the molecular weight of the chitosan is 5000~100000
Er Dun.
Further, the gel-type vehicle is polyvinyl alcohol.
Further, the Hemostatic of traditional herb medicine extract is one in Folium Artemisiae Argyi extract, Notogineng Extract and bletilla striata extract
Kind or several mixtures.
The present invention also provides a kind of hemostatic material in medical use, the hemostatic material in medical use includes following preparation process：
Combinations of the above object is added to the water and is uniformly dispersed to obtain mixed liquor；
Non-woven fabrics is immersed in the mixed liquor, is then dried to obtain.
Further, the non-woven fabrics is bamboo fiber nonwovens.
Further, the drying process is vacuum freeze drying.
Further, the dosage of the water is 1.5~2.5 times of total weight of the composition, and the water is deionization
Water.
Compared with prior art, the advantageous effect of the composition and hemostatic material in medical use for stopping blooding of the invention is：
The present invention makes full use of the effect of the ingredients such as collagen, chitosan, nano-silver powder and hemostasis Chinese herbal extract
Advantage and mutually synergistic effect, make the hemostatic material in medical use being prepared, with anthemorrhagic speed is fast, haemostatic effect is good, Neng Gouyou
The advantages that antibacterial bacteriostatic and good biocompatibility of effect, while the composition and hemostatic material in medical use pair for hemostasis of the present invention
Human body is safe to use to skin without any stimulation without Du's side effect.
To enable the above objects, features and advantages of the present invention to be clearer and more comprehensible, preferred embodiment cited below particularly is made detailed
It is described as follows.
Specific implementation mode
To facilitate the understanding of the present invention, it elaborates to technical scheme of the present invention with reference to the mode of embodiment,
Many details are elaborated in the following description in order to fully understand the present invention.
But the invention can be embodied in many other ways as described herein, those skilled in the art can be with
Similar improvement is done without violating the connotation of the present invention, therefore the present invention is not limited to the specific embodiments disclosed below.
Unless otherwise defined, all technologies used herein and scientific terminology have and the common skill of fields of the present invention
The normally understood identical meaning of art personnel.When there is a conflict, the definition in this specification shall prevail.
Term as used herein：
" by ... prepare " it is synonymous with "comprising".Term "comprising" used herein, " comprising ", " having ", " containing "
Or its any other deformation, it is intended that cover non-exclusionism includes.For example, composition, step, method comprising listed elements,
Product or device are not necessarily limited to those elements, but may include not expressly listed other elements or such composition, step
Suddenly, method, product or the intrinsic element of device.
Conjunction " by ... form " exclude any element that do not point out, step or component.If in claim,
This phrase will make claim be closed, so that it is not included the material in addition to the material of those descriptions, but relative
Except customary impurities.When phrase " by ... form " be rather than immediately following theme in the clause that appears in claim main body after
When, only it is limited to the element described in the clause；Other elements be not excluded the claim as a whole it
Outside.
Equivalent, concentration or other values or parameter are excellent with range, preferred scope or a series of upper limit preferred values and lower limit
When the Range Representation that choosing value limits, this, which should be understood as, specifically discloses by any range limit or preferred value and any range
Any pairing of lower limit or preferred value is formed by all ranges, regardless of whether the range separately discloses.For example, when open
When range " 1~5 ", described range should be interpreted as including range " 1~4 ", " 1~3 ", " 1~2 ", " 1~2 and 4~
5 ", " 1~3 and 5 " etc..When numberical range is described herein, unless otherwise stated, otherwise range intention includes its end
Value and all integers and score in the range.
"and/or" is used to indicate that one of illustrated situation or both may to occur, for example, A and/or B includes (A
And B) and (A or B).
A kind of composition for hemostasis includes the raw material of following parts by weight：
Such as 15 parts, 18 parts, 20 parts, 23 parts or 25 parts of 15~25 parts of collagen；
Such as 20 parts, 23 parts, 25 parts, 28 parts or 30 parts of 20~30 parts of chitosan；
Such as 1 part, 2 parts, 3 parts, 4 parts or 5 parts of 1~5 part of gel-type vehicle；
Such as 10 parts, 12 parts, 15 parts, 18 parts or 20 parts of 10~20 parts of nano-silver powder；
Such as 10 parts, 12 parts, 15 parts, 18 parts or 20 parts of hemostasis Chinese herbal extract etc..
It should be noted that collagen is a kind of bioabsorbable polymer material, and biological in-vivo content at most, distribution most
Wide functional protein can be fast with low immunogenicity, good biocompatibility, biodegradability and hemagglutinin
Speed is combined with the hemoglobin in blood, is formed hemostasis grumeleuse, capillary oozing of blood can be blocked to mechanical-physical, in addition, collagen
It after albumen and wound are combined closely, can penetrate into cambium, and holder when as cell growth.
Preferably, the collagen is Isin glue collagen.Isin glue collagen (polypeptide) is mainly new from Tilapia mossambica, gadus
Shearing technique extraction, predominantly I-type collagen are oriented by biological enzyme in fresh hide, fish scale, product is rich in 19 kinds of amino acid, point
Son amount has the very high property digested and assimilated, the thermal stability pole of this product in aqueous solution between 2000~5000D length
It is good, there is fabulous compatibility with human skin, can be good at the functions such as playing its infiltration and repair.
Certainly, the embodiment of the present invention is not intended to limit the type of collagen, is alternatively terrestrial animal collagen, but fish
Collagen is more preferable compared with the safety of terrestrial animal collagen and coagulating effectiveness.
Chitosan is that the chitin being widely present by nature is obtained by deacetylation, and chemical name is poly- grape
Osamine (1-4) -2- amino-betas-D-Glucose have excellent biological functionality, blood compatibility, safety and microorganism drop
Solution property etc..Chitosan can promote the migration of fibrocyte, have chemotactic, migration and activation to stroma cell, and accelerate cell
Proliferation and tissue remodeling promote skin histology reparation.Scar of the catabolite N-acetyl-glucosamine (NAG) of chitosan to tissue
It repairs extremely important.Chitosan itself also has anastalsis, by the interaction between red blood cell, mainly to red
The agglutination of cell and realize hemostasis.Its hemostatic mechanism is：Positively charged chitosan and the negatively charged god of cell surface
Receptor through histidine residue interacts, and promotes the aggregation of blood platelet, activates blood coagulation system.And chitosan has obviously
Film formation effect, can be with accelerating wound healing.
Preferably, the chitosan is water soluble chitosan, and the molecular weight of the chitosan is 5000~100000 dongles
.
Preferably, the gel-type vehicle is polyvinyl alcohol.But the present invention is not intended to limit the type of gel-type vehicle, it is described
Gel-type vehicle can also be carbomer or cellulose derivative such as hydroxypropyl methylcellulose etc..
Nano-silver powder has that antibacterial, strong bactericidal, permeability are strong, reparative regeneration, antibacterial is lasting, safety is nontoxic, without drug resistance
The characteristic and effect of property.Active silver ion preparation more can make sterilization, silver can for treating disease for environment space
Say it is that the best one kind of antibacterial is generally acknowledged in natural material, it is however generally that, it is thin that antibiotic can substantially kill 6 kinds of different pathogen
Bacterium, but silver can kill 650 kinds or more of bacterium, and silver material is not toxic, main cause is the biology that Yin Bensheng has
Effect.Active silver ion can attract the sulfydryl (- SH) on zymoprotein in bacterial body, rapidly be combined together, and make to contain
The ferment of sulfydryl loses activity, and then makes bacterial death.It is worth noting that：After bacterium is killed by silver ion, silver ion
Again can be from separate out on the bacterium to die, then the action of repetition is persistently done to bacterium living, until all bacteriums are destroyed, by
This is it is found that the effect of nano silver is to belong to long-acting type fungicide, it is however generally that, effectiveness can at least be kept 1 year.
Preferably, the Hemostatic of traditional herb medicine extract is one kind in Folium Artemisiae Argyi extract, Notogineng Extract and bletilla striata extract
Or several mixture.
Folium artemisiae argyi is also known as wormwood, ice platform, argy wormwood, doctor's grass, moxibustion grass, Chinese mugwort, yellow grass, family Chinese mugwort etc.；Its bitter, tepor, nontoxic, hardship
Dry pungent scattered, energy rationale blood warm meridians, expels cold-dampness, stops crymodynia.Folium Artemisiae Argyi extract has eliminating cold to stop pain, warming channel for arresting bleeding and other effects.
Radix Notoginseng also known as pseudo-ginseng, blood ginseng, blood mountain grass etc., it is sweet in flavor, slight bitter, warm-natured.Notogineng Extract has removing blood stasis and hemostasis, work
The effect of blood analgesic therapy.
The bletilla striata also known as Lian Jicao, Gan Gen, Zhu Lan etc., it is acrid flavour, hardship, sweet, puckery.The bletilla striata can enhance the work of blood platelet factor III
Property, significantly shorten the clotting time and factor forms the time, inhibit plasmin enzymatic activity, there is hemostasis to make local hemorrhage
With also with antifungic action, the 3 biphenyl classes and 2 double hydrogen phenanthrene class compounds contained by bletilla are to Staphylococcus aureus
Bacterium, hay bacillus, Candida albicans ATCC1057 and trichophyte QM248 have inhibiting effect.Bletilla striata extract have astringing to arrest bleeding,
The effect of detumescence and promoting granulation.And contain gelling ingredient in the bletilla striata, a kind of protective film can be formed in the surface of a wound.
Preferably, the Folium Artemisiae Argyi extract, the Notogineng Extract and the bletilla striata extract are deionized water extraction
Object is obtained folium artemisiae argyi, Radix Notoginseng and the bletilla striata using existing water extraction concentration technique.Preferably, the Folium Artemisiae Argyi extract is：It will
Folium artemisiae argyi presses 1 with deionized water：5~8 mass ratio mixing, then after decoction filtering, then concentration extraction obtains.The Radix Notoginseng carries
The object is taken to be：Radix Notoginseng and deionized water are pressed 1：10~15 mass ratio mixing, then after decoction filtering, then concentration extraction obtains
It arrives.The bletilla striata extract is：The bletilla striata and deionized water are pressed 1：6~11 mass ratio mixing, then after decoction filtering, then
Concentration extraction obtains.
It should be noted that several mixtures is at least two mixing in any proportion of folium artemisiae argyi, Radix Notoginseng and the bletilla striata
Object.
The present invention makes full use of the effect of the ingredients such as collagen, chitosan, nano-silver powder and hemostasis Chinese herbal extract
Advantage and mutually synergistic effect, make the hemostatic material in medical use being prepared, with anthemorrhagic speed is fast, haemostatic effect is good, Neng Gouyou
The advantages that antibacterial bacteriostatic and good biocompatibility of effect, while the composition and hemostatic material in medical use pair for hemostasis of the present invention
Human body is safe to use to skin without any stimulation without Du's side effect.
Preferably, the composition further includes the raw material of following parts by weight：
Such as 1 part, 2 parts, 3 parts, 4 parts or 5 parts of 1~5 part of Lasiosphaera fenzlii conidia powder.
It should be noted that Lasiosphaera fenzlii, nature and flavor are pungent, flat, nontoxic, containing Argine Monohydrochloride, cheese base acid, urea, ergosterol,
Lipoids, gemmatein etc. have the function of anti-inflammatory, antibacterial, hemostasis.
Lasiosphaera fenzlii is preferably peelled off exoperidium by Lasiosphaera fenzlii conidia powder, is dug out content and is sifted out spore, then by spore in 110-
130 degrees Celsius dry, pulverize after cross the Lasiosphaera fenzlii conidia powder that is obtained with upper screen cloth of 100 mesh.By the Lasiosphaera fenzlii conidia powder handled above
With better antibacterial, haemostatic effect.Lasiosphaera fenzlii conidia powder stores a large amount of micro- porous fibres, can absorb the water in blood rapidly
Point, can mechanicalness block blood vessel cut and capillary oozing of blood, while wound can be isolated in this physical barriers, play and prevent adhesion, i.e.
When the effect stopped blooding.
The present invention also provides a kind of hemostatic material in medical use, the hemostatic material in medical use includes following preparation process：
(1) combinations of the above object is added to the water and is uniformly dispersed to obtain dispersion liquid, it is preferable that the dispersing mode is using super
Sound disperses, and ultrasonic power is preferably 400~800W.Certainly, the dispersing mode can also be to be dispersed with stirring or vibrating dispersion.
Preferably, the dosage of the water be 1.5~3 times of total weight of the composition as 1.5 times, 1.8 times, 2.0 times,
2.3 times, 2.5 times or 3 times etc..
Preferably, the water is deionized water.Certainly, the water can also be distilled water.
(2) non-woven fabrics is immersed in the dispersion liquid, is then dried to obtain.
Preferably, the non-woven fabrics is bamboo fiber nonwovens.But the present invention is not intended to limit the type of non-woven fabrics, it is described
Non-woven fabrics can also be plant fiber spunlace non-woven cloth.
Bamboo charcoal fiber has effects that good hygroscopic desiccation, antibacterial deodorizing, stimulates human body zero and without negative interaction.It needs
It is noted that bamboo charcoal fiber is in inside and outside perforative honeycomb microporous structure, which is especially advantageous for collagen, nano silver
The implantation of the functional materials such as powder, hemostasis Chinese herbal extract.
Preferably, the drying process is vacuum freeze drying.
More preferably, the drying process is the vacuum freeze drying 18~for 24 hours at -15~10 DEG C.
To facilitate the understanding of the present invention, the technical solution further illustrated the present invention with reference to embodiment.Applicant
Statement, the present invention are illustrated by the following examples detailed process equipment and the technological process of the present invention, but the present invention not office
It is limited to following detailed process equipments and technological process, that is, does not mean that the present invention should rely on above-mentioned detailed process equipment and technique stream
Cheng Caineng is implemented.Person of ordinary skill in the field is it will be clearly understood that any improvement in the present invention, to each original of product of the present invention
The equivalence replacement of material and the addition of auxiliary element, the selection of concrete mode etc. all fall within protection scope of the present invention and open model
Within enclosing.
Embodiment 1
A kind of specific preparation process of hemostatic material in medical use is as follows：
(1) 15 parts of Isin glue collagens, 20 parts of chitosans, 1 part of polyvinyl alcohol, 10 parts of nano-silver powders, 5 parts of folium artemisiae argyi extractions are weighed
Object and 5 parts of bletilla striata extracts, it is spare.
(2) after mixing by each raw material in step (1), it is added in 112 parts of deionized waters, under the ultrasonic power of 400W
Ultrasonic disperse 1.5h, obtains dispersion liquid.
(3) bamboo fiber nonwovens are immersed in 6h in the dispersion liquid of step (2) preparation, take out the non-woven fabrics after dipping,
It is freeze-dried for 24 hours to get hemostatic material in medical use in the vacuum freeze drier that temperature is -10 DEG C.
Embodiment 2
A kind of specific preparation process of hemostatic material in medical use is as follows：
(1) 20 parts of Isin glue collagens, 25 parts of chitosans, 3 parts of polyvinyl alcohol, 15 parts of nano-silver powders, 5 parts of folium artemisiae argyi extractions are weighed
Object and 10 parts of bletilla striata extracts, it is spare.
(2) after mixing by each raw material in step (1), it is added in 156 parts of deionized waters, under the ultrasonic power of 600W
Ultrasonic disperse 1.5h, obtains dispersion liquid.
(3) bamboo fiber nonwovens are immersed in 8h in the dispersion liquid of step (2) preparation, take out the non-woven fabrics after dipping,
It is freeze-dried 20h in the vacuum freeze drier that temperature is -15 DEG C, obtains hemostatic material in medical use.
Embodiment 3
A kind of specific preparation process of hemostatic material in medical use is as follows：
(1) 25 parts of Isin glue collagens, 30 parts of chitosans, 5 parts of polyvinyl alcohol, 20 parts of nano-silver powders, 8 parts of folium artemisiae argyi extractions are weighed
Object and 12 parts of bletilla striata extracts, it is spare.
(2) after mixing by each raw material in step (1), it is added in 250 parts of deionized waters, under the ultrasonic power of 800W
Ultrasonic disperse 1h, obtains dispersion liquid.
(3) bamboo fiber nonwovens are immersed in 10h in the dispersion liquid of step (2) preparation, take out the non-woven fabrics after dipping,
It is freeze-dried 22h in the vacuum freeze drier that temperature is -10 DEG C, obtains hemostatic material in medical use.
Embodiment 4
A kind of specific preparation process of hemostatic material in medical use is as follows：
(1) 18 parts of Isin glue collagens, 23 parts of chitosans, 2 parts of polyvinyl alcohol, 12 parts of nano-silver powders, 4 parts of folium artemisiae argyi extractions are weighed
Object, 5 parts of Notogineng Extracts, 3 parts of bletilla striata extracts and 1 part of Lasiosphaera fenzlii conidia powder, it is spare.
(2) after mixing by each raw material in step (1), it is added in 100 parts of deionized waters, under the ultrasonic power of 500W
Ultrasonic disperse 1.5h, obtains dispersion liquid.
(3) bamboo fiber nonwovens are immersed in 10h in the dispersion liquid of step (2) preparation, take out the non-woven fabrics after dipping,
It is freeze-dried 18h in the vacuum freeze drier that temperature is -15 DEG C, obtains hemostatic material in medical use.
Embodiment 5
A kind of specific preparation process of hemostatic material in medical use is as follows：
(1) 20 parts of Isin glue collagens, 23 parts of chitosans, 3 parts of polyvinyl alcohol, 15 parts of nano-silver powders, 5 parts of folium artemisiae argyi extractions are weighed
Object, 5 parts of Notogineng Extracts, 8 parts of bletilla striata extracts and 2 parts of Lasiosphaera fenzlii conidia powders, it is spare.
(2) after mixing by each raw material in step (1), it is added in 150 parts of deionized waters, under the ultrasonic power of 600W
Ultrasonic disperse 1.5h, obtains dispersion liquid.
(3) bamboo fiber nonwovens are immersed in 8h in the dispersion liquid of step (2) preparation, take out the non-woven fabrics after dipping,
It is freeze-dried for 24 hours in the vacuum freeze drier that temperature is -10 DEG C, obtains hemostatic material in medical use.
Embodiment 6
A kind of specific preparation process of hemostatic material in medical use is as follows：
(1) 15 parts of Isin glue collagens, 20 parts of chitosans, 1 part of polyvinyl alcohol, 10 parts of nano-silver powders, 4 parts of folium artemisiae argyi extractions are weighed
Object, 10 parts of Notogineng Extracts, 4 parts of bletilla striata extracts and 3 parts of Lasiosphaera fenzlii conidia powders, it is spare.
(2) after mixing by each raw material in step (1), it is added in 120 parts of deionized waters, under the ultrasonic power of 400W
Ultrasonic disperse 1.5h, obtains dispersion liquid.
(3) bamboo fiber nonwovens are immersed in 6h in the dispersion liquid of step (2) preparation, take out the non-woven fabrics after dipping,
It is freeze-dried 20h in the vacuum freeze drier that temperature is -10 DEG C, obtains hemostatic material in medical use.
Embodiment 7
A kind of specific preparation process of hemostatic material in medical use is as follows：
(1) 15 parts of Isin glue collagens, 20 parts of chitosans, 1 part of polyvinyl alcohol, 10 parts of nano-silver powders, 5 parts of folium artemisiae argyi extractions are weighed
Object, 10 parts of Notogineng Extracts, 5 parts of bletilla striata extracts and 4 parts of Lasiosphaera fenzlii conidia powders, it is spare.
(2) after mixing by each raw material in step (1), it is added in 150 parts of deionized waters, under the ultrasonic power of 500W
Ultrasonic disperse 1.5h, obtains dispersion liquid.
(3) bamboo fiber nonwovens are immersed in 10h in the dispersion liquid of step (2) preparation, take out the non-woven fabrics after dipping,
It is freeze-dried 22h in the vacuum freeze drier that temperature is -10 DEG C, obtains hemostatic material in medical use.
Embodiment 8
A kind of specific preparation process of hemostatic material in medical use is as follows：
(1) 15 parts of Isin glue collagens, 20 parts of chitosans, 1 part of polyvinyl alcohol, 10 parts of nano-silver powders, 5 parts of folium artemisiae argyi extractions are weighed
Object, 12 parts of Notogineng Extracts, 3 parts of bletilla striata extracts and 5 parts of Lasiosphaera fenzlii conidia powders, it is spare.
(2) after mixing by each raw material in step (1), it is added in 160 parts of deionized waters, under the ultrasonic power of 600W
Ultrasonic disperse 1.5h, obtains dispersion liquid.
(3) bamboo fiber nonwovens are immersed in 8h in the dispersion liquid of step (2) preparation, take out the non-woven fabrics after dipping,
It is freeze-dried for 24 hours in the vacuum freeze drier that temperature is -10 DEG C, obtains hemostatic material in medical use.
Comparative example 1
This comparative example is not the difference from example 2 is that add Folium Artemisiae Argyi extract and bletilla striata extract.
Comparative example 2
This comparative example is not the difference from example 2 is that add Isin glue collagen.
Comparative example 3
This comparative example is not the difference from example 2 is that add nano silver.
Bleeding stopping period is carried out to the hemostatic material in medical use of 1~3 gained of the embodiment of the present invention 1~8 and comparative example, is stretched by force
Degree, biocompatibility and staphylococcus aureus bacteriostasis rate performance test, the results are shown in Table 1：
Table 1
By 1 result of above-mentioned table it is found that medical treatment of the medical haemostatic material compared with comparative example 1~3 of the embodiment of the present invention 1~8 stops
The bleeding stopping period of blood material faster, staphylococcus aureus bacteriostasis rate higher.
The preferred embodiment of the present invention is above are only, is not intended to restrict the invention, for those skilled in the art
For member, inventive formulation and preparation process can have various modifications and variations.All within the spirits and principles of the present invention, institute
Any modification, equivalent substitution, improvement and etc. of work, should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of composition for hemostasis, it is characterised in that：Include the raw material of following parts by weight：Collagen 15~25
Part, 20~30 parts of chitosan, 1~5 part of gel-type vehicle, 10~20 parts of nano-silver powder and 10~20 parts of hemostasis Chinese herbal extract.
2. the composition according to claim 1 for hemostasis, it is characterised in that：It further include the original of following parts by weight
Material：1~5 part of Lasiosphaera fenzlii conidia powder.
3. the composition according to claim 1 for hemostasis, it is characterised in that：The collagen is collagen egg
In vain.
4. the composition according to claim 1 for hemostasis, it is characterised in that：The chitosan is poly- for water soluble shells
The molecular weight of sugar, the chitosan is 5000~100000 dalton.
5. the composition according to claim 1 for hemostasis, it is characterised in that：The gel-type vehicle is polyvinyl alcohol.
6. the composition according to claim 1 for hemostasis, it is characterised in that：The Hemostatic of traditional herb medicine extract is folium artemisiae argyi
The mixture of one or more of extract, Notogineng Extract and bletilla striata extract.
7. a kind of hemostatic material in medical use, it is characterised in that：The hemostatic material in medical use includes following preparation process：
The composition of claim 1~6 any one of them is added to the water and is uniformly dispersed to obtain mixed liquor；
Non-woven fabrics is immersed in the mixed liquor, is then dried to obtain.
8. hemostatic material in medical use according to claim 7, it is characterised in that：The non-woven fabrics is bamboo fiber nonwovens.
9. hemostatic material in medical use according to claim 7, it is characterised in that：The drying process is vacuum freeze drying.
10. hemostatic material in medical use according to claim 7, it is characterised in that：The dosage of the water is the composition
1.5~2.5 times of total weight, the water are deionized water.
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