CN108744022A - A kind of functionality absorbable hemostatic powder and preparation method thereof - Google Patents
A kind of functionality absorbable hemostatic powder and preparation method thereof Download PDFInfo
- Publication number
- CN108744022A CN108744022A CN201810736887.9A CN201810736887A CN108744022A CN 108744022 A CN108744022 A CN 108744022A CN 201810736887 A CN201810736887 A CN 201810736887A CN 108744022 A CN108744022 A CN 108744022A
- Authority
- CN
- China
- Prior art keywords
- parts
- functionality
- hemostatic powder
- absorbable hemostatic
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0042—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention discloses a kind of functional absorbable hemostatic powder, and the active ingredient of the functionality absorbable hemostatic powder includes the substance of following weight parts：3~10 parts of 20~40 parts of natural marine polysaccharide, 5~15 parts of natural mineral salt and Hemostatic of traditional herb medicine.Functionality absorbable hemostatic powder large specific surface area provided by the invention, it is not limited by the surface of a wound size and shape when for stopping blooding, it can well be contacted with wound, water imbibition is strong, the moisture in blood, the blood coagulations active ingredient such as coagulation factor in concentrate blood can be absorbed in the moment contacted with wound, sludged blood is formed in short time, achievees the effect that quick-acting haemostatic powder.
Description
Technical field
The invention belongs to hemostatic material in medical use technical fields, and in particular to a kind of functionality absorbable hemostatic powder and its preparation
Method.
Background technology
Hemostasis be in face of bleeding situation carry out initial treatment means, and the selection of hemostatic material be it is vital,
Especially when in face of burst accident, quickly and effectively hemostatic material is carried out giving treatment to the life that can save the wounded or be drawn for selection
Its limbs or organ are rescued, casualty rate is reduced.The topical hemostatic agent clinically used at present mainly has hemostatic gauze, tourniquet bandage
Deng, but these materials cannot be all absorbed by tissue, and bleeding stopping period is longer, haemostatic effect is poor.Rapidly and efficiently stop blooding not
It is only capable of mitigating the pain of the wounded, or even the life of patient can be saved at the time of key.Some domestic new hemostasia products such as shells are poly-
Sugared hemostatic adhesive bandage, gelfoam, collagen protein sponge hemostatic adhesive bandage etc., the treatment being used for when irregular surface of a wound bleeding is limited, hemostatic material
Material cannot be contacted with the surface of a wound well, and therefore, haemostatic effect is undesirable.Pulvis hemostatic material because with larger specific surface area and
Absorbability can not be limited by surface of a wound shapes and sizes, while can absorb the blood of the surface of a wound, and the pollution of wound site is avoided
Influence treatment.
Invention content
The purpose of the present invention is to provide a kind of functional absorbable hemostatic powder, to solve the above technical problems at least
One.
It is above-mentioned to solve it is another object of the present invention to provide the preparation method of above-mentioned functional absorbable hemostatic powder
At least one of technical problem.
According to an aspect of the invention, there is provided a kind of functionality absorbable hemostatic powder, active ingredient includes following
The substance of parts by weight：3~10 parts of 20~40 parts of natural marine polysaccharide, 5~15 parts of natural mineral salt and Hemostatic of traditional herb medicine.
Functionality absorbable hemostatic powder provided by the invention is based on natural marine polysaccharide, natural mineral salt and Hemostatic of traditional herb medicine
Raw material is prepared, these prepare the natural materials that raw material is degradable, safety non-toxic, wherein natural marine polysaccharide is not only
With good biocompatibility, degradability, while also there is good haemostatic effect；Natural mineral salt has good suction
It is aqueous, and there is natural minerals salt material itself more microcellular structure, large specific surface area can quickly absorb the water in blood
Point, the blood coagulations active ingredient such as coagulation factor, blood platelet in concentrate blood reaches quick to promote the formation of sludged blood
The effect of hemostasis；Have closing damaged containing the active ingredient with hemostasia effect, these hemostasis active ingredients in Hemostatic of traditional herb medicine
The effects that blood vessel, cohesion coagulation factor or blood platelet, can accelerate blood clotting, auxiliary natural marine polysaccharide, natural minerals
Salt shortens the clotting time.Functionality absorbable hemostatic powder large specific surface area provided by the invention is not big by the surface of a wound when for stopping blooding
Small and shape limitation, can well contact with wound, and water imbibition is strong, can absorb blood in the moment contacted with wound
In moisture, the blood coagulations active ingredient such as coagulation factor in concentrate blood forms sludged blood, reaches quick-acting haemostatic powder in the short time
Effect.
In the present invention, natural marine polysaccharide, natural mineral salt and Hemostatic of traditional herb medicine three synergistic effect not only can effectively contract
Short bleeding stopping period, significantly improves haemostatic effect, and functionality absorbable hemostatic powder obtained also has good biocompatibility, can
Absorbability and significant antibacterial action, safety non-toxic can effectively inhibit wound site germ to grow, and contribute to being cured for wound
It closes.
In some embodiments, the functional absorbable hemostatic powder of the present invention has porous microsphere structure, in scanning electron
It is observed under microscope (SEM), is mainly that there are many microballoons of micropore for the irregular distribution in surface and inside.Functionality of the present invention can
Styptic powder large specific surface area is absorbed, water absorbing properties are good, are conducive to shorten the clotting time, improve haemostatic effect.
In some embodiments, natural mineral salt of the present invention can be in montmorillonite, kaolin, zeolite, bentonite
At least one.Above-mentioned natural mineral salt water imbibition is strong, microcellular structure itself is more, large specific surface area, and with natural marine polysaccharide
Compatibility it is good, thus, it is possible to improve the haemostatic effect of absorbable hemostatic powder.
Natural marine polysaccharide is the natural high molecular reactive polysaccharide that extracting and developing, purifying obtain from marine organisms, root
It can be divided into three categories according to its source difference：Algal polysaccharides, marine animal polysaccharide and marine microorganism polysaccharide.In some embodiments
In, natural marine polysaccharide of the present invention is selected from least one of alginate, chitosan, agar-agar.Work(can be not only improved as a result,
The haemostatic effect of energy property absorbable hemostatic powder, additionally aids the quick healing for promoting wound.
As a preferred embodiment of the present invention, natural marine polysaccharide can be sodium alginate.Sodium alginate conduct
Hemostatic material, after being contacted with wound, water suction forms hydrogel and is attached to wound surface, and sodium alginate absorbs water the hydrogel to be formed tool
There is hydrophily, on the other hand the environment of a moistening on the one hand can be provided for the healing of wound can make oxygen pass through, stop
Bacterium, to contribute to the quick healing of wound.It is further preferred that the molecular weight of sodium alginate can be 20~300,000.
Hemostatic of traditional herb medicine of the present invention refers to the Chinese medicine for having anastalsis, can be with Hemostatic of traditional herb medicine powder (i.e. Hemostatic of traditional herb medicine powder
The powder that breakdown mill obtains) or the form of Hemostatic of traditional herb medicine extract be applied to prepare the functional absorbable hemostatic powder of the present invention.?
In some embodiments, Hemostatic of traditional herb medicine of the present invention is selected from least one of Radix Notoginseng, the bletilla striata, field thistle, carbonized hair, catechu.As a result,
The haemostatic effect of functional absorbable hemostatic powder can be not only improved, functional can absorb only can also be improved by acting synergistically
The antibacterial action of blood meal makes functional absorbable hemostatic powder for when stopping blooding, can effectively inhibit wound site germ to grow, have
Help the healing of wound.
In some embodiments, the functional absorbable hemostatic powder active ingredient of the present invention is counted in parts by weight, further includes
2~8 parts of antalgesic.Thus, it is possible to alleviate the pain of wound while hemostasis.
Antalgesic of the present invention refers to the medicine for having analgesic effect, preferably Chinese herbal medicine or its extract with analgesic effect.
In some embodiments, antalgesic of the present invention is selected from least one of menthol, borneol.Thus, it is possible to relieve pain, disappear
Except swelling, accelerate wound healing.
As a preferred embodiment of the present invention, count in parts by weight, present invention functionality absorbable hemostatic powder
Active ingredient prepares raw material, including：25 parts of natural marine polysaccharide, 10 parts of natural mineral salt, 7 parts of Hemostatic of traditional herb medicine and antalgesic 5
Part.Functional absorbable hemostatic powder obtained has the characteristics such as good biocompatibility, safe and non-toxic, absorbability as a result,
Large specific surface area, water imbibition is strong, can well be contacted with wound when for stopping blooding, bleeding stopping period is short, and haemostatic effect is notable, together
When can relieve pain and promote the healing of wound.
According to another aspect of the present invention, the preparation method of above-mentioned functional absorbable hemostatic powder is provided, including such as
Lower step：
S1, natural marine polysaccharide is configured to natural marine polysaccharide solution, then sequentially adds pore-foaming agent, natural minerals
Salt, Hemostatic of traditional herb medicine and antalgesic, after mixing liquid A；
S2, sorbester p17 preparation solution B is added in vegetable oil, then liquid A is added in liquid B and emulsifies, obtains emulsion；
S3, cross-linking reaction will be carried out in crosslinking agent addition emulsion, and absolute ethyl alcohol solidification will be added after cross-linking reaction, finally
Centrifugation, washing, it is dry to get.
The preparation process of the functional absorbable hemostatic powder of the present invention is simple, and convenient operation and control, functionality obtained can
It is to have prodigious specific surface area and absorbability with perhaps microporous microballoon to absorb styptic powder, can well with wound site
Contact, meanwhile, the body fluid of the surface of a wound can be quickly absorbed, bleeding stopping period is shortened, it is apparent for the haemostatic effect of the irregular surface of a wound.
In some embodiments, in step S1, the concrete operations of preparation solution A may include steps of：By natural sea
Foreign polysaccharide is configured to the natural marine polysaccharide solution that mass concentration is 1.5~2.5%, then sequentially adds pore-foaming agent, natural
Mineral salt, Hemostatic of traditional herb medicine and antalgesic, after stirring evenly, standing and defoaming is to get liquid A.Wherein, pore-foaming agent can be selected from chlorination
At least one of sodium, sucrose, ethyl acetate, hexamethylene, chloroform, polyethylene glycol, are counted in parts by weight, and the dosage of pore-foaming agent can
Think 2~5 parts.
As a preferred embodiment of the present invention, natural mineral salt, Hemostatic of traditional herb medicine and antalgesic can be through crushed
It is added in natural marine polysaccharide solution after 100~300 mesh sieve.
In some embodiments, in step S2, the concrete operations for preparing emulsion may include steps of：By weight
Number meter takes 1~3 part of sorbester p17, is then 1 according to the volume ratio of liquid A and liquid B：(5~10) take vegetable oil, in vegetable oil
Sorbester p17 is added, is uniformly mixed to get liquid B, then liquid A is added in liquid B and emulsifies to get emulsion.
As a preferred embodiment of the present invention, vegetable oil can be soybean oil.
In some embodiments, in above-mentioned steps S2, liquid A is added the temperature emulsified in liquid B can be 30~
45 DEG C, stir speed (S.S.) can be 450~600rpm/min, and mixing time can be 25~35min.
In some embodiments, in step S3, the step of carrying out cross-linking reaction is added in emulsion in crosslinking agent, specifically
It may include steps of：Crosslinking agent is configured to the cross-linking agent solution that mass concentration is 1~7%, then by cross-linking agent solution
It is added drop-wise in emulsion and carries out cross-linking reaction, drip speed control at 1~2 drop/sec, cross-linking reaction time is 90~120min；Wherein,
Crosslinking agent can be selected from least one of calcium chloride, glutaraldehyde, formaldehyde, Geniposide, sodium tripolyphosphate, tannic acid, by weight
The dosage of number meter, crosslinking agent can be 3~5 parts.
Big vast in some embodiments, in step S3, after cross-linking reaction plus the cured concrete operations of absolute ethyl alcohol can
To include the following steps：After cross-linking reaction, the absolute ethyl alcohol that 1~2 times of amount of liquid B volumes is added into reaction solution is consolidated
Change, hardening time is 30~60min.
In some embodiments, the preparation method of the functional absorbable hemostatic powder of the present invention, includes the following steps：
S1, natural marine polysaccharide is configured to the natural marine polysaccharide solution that mass concentration is 2%, then sequentially added
Pore-foaming agent, natural mineral salt, Hemostatic of traditional herb medicine and antalgesic, after stirring evenly, standing and defoaming is to get liquid A, wherein by weight
The dosage of number meter, pore-foaming agent is 3 parts；
S2, it counts in parts by weight, takes 2 parts of sorbester p17s, be then 1 according to the volume ratio of liquid A and liquid B：(5~10) take plant
Sorbester p17 is added in oil in vegetable oil, is uniformly mixed to get liquid B, and then liquid A is added in liquid B and emulsifies, is emulsified
Liquid；Wherein, the temperature emulsified is 40 DEG C, stir speed (S.S.) 500rpm/min, mixing time 30min；
S3, crosslinking agent is configured to the cross-linking agent solution that mass concentration is 5%, cross-linking agent solution is then added drop-wise to emulsification
It carries out cross-linking reaction in liquid, drips speed control at 1 drop/sec, cross-linking reaction time 100min；After cross-linking reaction, toward reaction
The absolute ethyl alcohol that 1 times of amount of liquid B volumes is added in liquid is cured, hardening time 45min, is finally centrifuged, is washed, is dry, i.e.,
Obtain functional absorbable hemostatic powder, wherein count in parts by weight, the dosage of crosslinking agent is 5 parts.
Description of the drawings
Fig. 1 is the SEM figures of functional absorbable hemostatic powder made from the embodiment of the present invention 3；
Fig. 2 is the SEM figures of the partial enlargement of functional absorbable hemostatic powder surface shown in Fig. 1.
Specific implementation mode
With reference to embodiment and attached drawing, the present invention is described in further detail.
Embodiment 1
Formula：It counts in parts by weight, including prepares raw material as follows：20 parts of sodium alginate, 8 parts of montmorillonite, 3 parts of Radix Notoginseng powder,
3 parts of 2 parts of borneol, 2 parts of sodium chloride, 1.5 parts of sorbester p17 and calcium chloride.
Preparation method：
S1, sodium alginate is configured to the sodium alginate aqueous solution that mass concentration is 2% with deionized water, then added successively
Enter sodium chloride, montmorillonite, Radix Notoginseng powder and borneol, after stirring evenly, standing and defoaming is to get liquid A；Montmorillonite, Radix Notoginseng powder and borneol
It needs to crushed 200 mesh sieve before addition；
S2, sorbester p17 is taken, is then 1 according to the volume ratio of liquid A and liquid B：5 take vegetable oil, and sapn is added in vegetable oil
80, it is uniformly mixed to get liquid B, then liquid A is added in liquid B and emulsifies, obtains emulsion；Wherein, the temperature emulsified
It is 35 DEG C, stir speed (S.S.) 600rpm/min, mixing time 25min；
S3, calcium chloride is configured to the calcium chloride solution that mass concentration is 5% with deionized water, then by calcium chloride solution
It is added drop-wise in emulsion and carries out cross-linking reaction, drip speed control at 1 drop/sec, cross-linking reaction time 90min；Cross-linking reaction terminates
Afterwards, the absolute ethyl alcohol that 1 times of amount of liquid B volumes is added into reaction solution is cured, and hardening time 50min is finally centrifuged, washed
It washs, dry to get functional absorbable hemostatic powder.
Embodiment 2
Formula：It counts in parts by weight, including prepares raw material as follows：It is 20 parts of chitosan, 8 parts of kaolin, 5 parts of carbonized hair, thin
4 parts of 3 parts of lotus brain, 3 parts of hexamethylene, 1.5 parts of sorbester p17 and sodium tripolyphosphate.
Preparation method：
S1, chitosan is configured to the chitosan aqueous solution that mass concentration is 1.5% with 1% aqueous acetic acid, then
Hexamethylene, kaolin, carbonized hair and menthol are sequentially added, after stirring evenly, standing and defoaming is to get liquid A；More than kaolin, blood
Charcoal and menthol need to crushed 200 mesh sieve before being added；
S2, sorbester p17 is taken, is then 1 according to the volume ratio of liquid A and liquid B：10 take vegetable oil, and sapn is added in vegetable oil
80, it is uniformly mixed to get liquid B, then liquid A is added in liquid B and emulsifies, obtains emulsion；Wherein, the temperature emulsified
It is 42 DEG C, stir speed (S.S.) 450rpm/min, mixing time 35min；
S3, sodium tripolyphosphate is configured to the sodium tripolyphosphate solution that mass concentration is 3% with deionized water, then by three
Polyphosphate sodium solution, which is added drop-wise in emulsion, carries out cross-linking reaction, drips speed control at 2 drops/sec, cross-linking reaction time 120min；
After cross-linking reaction, the absolute ethyl alcohol that 1 times of amount of liquid B volumes is added into reaction solution is cured, hardening time 30min,
It finally centrifuges, wash, is dry to get functional absorbable hemostatic powder.
Embodiment 3
Formula：It counts in parts by weight, including prepares raw material as follows：It is 25 parts of sodium alginate, 10 parts of montmorillonite, 7 parts of catechu, thin
5 parts of 5 parts of lotus brain, 3 parts of sucrose, 2 parts of sorbester p17 and calcium chloride.
Preparation method：
S1, sodium alginate is configured to the sodium alginate aqueous solution that mass concentration is 2% with deionized water, then added successively
Enter sucrose, montmorillonite, catechu and menthol, after stirring evenly, standing and defoaming is to get liquid A；Montmorillonite, catechu and menthol add
It needs to crushed 200 mesh sieve before entering；
S2, sorbester p17 is taken, is then 1 according to the volume ratio of liquid A and liquid B：10 take vegetable oil, and sapn is added in vegetable oil
80, it is uniformly mixed to get liquid B, then liquid A is added in liquid B and emulsifies, obtains emulsion；Wherein, the temperature emulsified
It is 40 DEG C, stir speed (S.S.) 500rpm/min, mixing time 30min；
S3, calcium chloride is configured to the calcium chloride solution that mass concentration is 5% with deionized water, then by sodium tripolyphosphate
Solution, which is added drop-wise in emulsion, carries out cross-linking reaction, drips speed control at 1 drop/sec, cross-linking reaction time 100min；Cross-linking reaction
After, the absolute ethyl alcohol that 1 times of amount of liquid B volumes is added into reaction solution is cured, hardening time 45min, finally centrifugation,
Washing, drying are to get functional absorbable hemostatic powder.
The micro-structure diagram of functional absorbable hemostatic powder made from the present embodiment is as depicted in figs. 1 and 2, by Fig. 1 and Fig. 2
It is found that present invention functionality absorbable hemostatic powder has porous microsphere structure.
The haemostatic effect of functional absorbable hemostatic powder of the invention is evaluated by the docking Hemorrhage Model of SD rats,
Concrete operations are：The tail of SD rats is cut into a part, sprinkles work(made from the embodiment of the present invention 3 on wound immediately after
Energy property absorbable hemostatic powder, measures bleeding stopping period.It is tested through being repeated several times, test result shows of the invention functional absorbable
Styptic powder haemostatic effect is notable, can successfully stop blooding within 1min in the experiment of actual wounds in animals, haemostatic effect is apparent
Better than styptic powders such as Yunnan Baiyao, the average bleeding stopping period of Yunnan Baiyao is more than 1.5min.In addition, can using functionality of the present invention
After absorbing styptic powder, rat tails wound is stimulated, rat reacts without irritability, should be the result shows that functionality of the present invention can
Absorbing styptic powder has significant analgesic effect.
Above-described is only some embodiments of the present invention.For those of ordinary skill in the art, not
Under the premise of being detached from the invention design, various modifications and improvements can be made, these belong to the protection model of the present invention
It encloses.
Claims (10)
1. functional absorbable hemostatic powder, which is characterized in that its active ingredient includes the substance of following weight parts：Natural marine is more
3~10 parts of 20~40 parts of sugar, 5~15 parts of natural mineral salt and Hemostatic of traditional herb medicine.
2. functionality absorbable hemostatic powder according to claim 1, which is characterized in that the functionality absorbable hemostatic powder
With porous microsphere structure.
3. functionality absorbable hemostatic powder according to claim 2, which is characterized in that the natural mineral salt, which is selected to cover, to be taken off
At least one of soil, kaolin, zeolite, bentonite；The natural marine polysaccharide is in alginate, chitosan, agar-agar
At least one；The Hemostatic of traditional herb medicine is selected from least one of Radix Notoginseng, the bletilla striata, field thistle, carbonized hair, catechu.
4. according to claims 1 to 3 any one of them functionality absorbable hemostatic powder, which is characterized in that its active ingredient is pressed
Parts by weight meter further includes 2~8 parts of antalgesic.
5. functionality absorbable hemostatic powder according to claim 4, which is characterized in that the antalgesic be selected from menthol,
At least one of borneol.
6. the preparation method of functionality absorbable hemostatic powder according to claim 5, which is characterized in that including walking as follows
Suddenly：
S1, natural marine polysaccharide is configured to natural marine polysaccharide solution, pore-foaming agent, natural mineral salt, hemostasis is then added
Chinese medicine and antalgesic, after mixing liquid A；
S2, sorbester p17 preparation solution B is added in vegetable oil, then liquid A is added in liquid B and emulsifies, obtains emulsion；
S3, crosslinking agent is added in emulsion carry out cross-linking reaction, after cross-linking reaction plus absolute ethyl alcohol solidification, finally from
The heart, washing, it is dry to get.
7. the preparation method of functionality absorbable hemostatic powder according to claim 6, which is characterized in that in step S1, institute
The mass concentration for stating natural marine polysaccharide solution is 1.5~2.5%；The pore-foaming agent is selected from sodium chloride, sucrose, acetic acid second
At least one of ester, hexamethylene, chloroform, polyethylene glycol, are counted in parts by weight, and the dosage of the pore-foaming agent is 2~5 parts.
8. the preparation method of functionality absorbable hemostatic powder according to claim 6, which is characterized in that in step S2, institute
The volume ratio for stating liquid A and liquid B is 1：(5~10)；It counts in parts by weight, the dosage of the sorbester p17 is 1~3 part.
9. the preparation method of functionality absorbable hemostatic powder according to claim 8, which is characterized in that, will in step S2
It is 30~45 DEG C that the temperature emulsified in liquid B, which is added, in liquid A, and stir speed (S.S.) is 450~600rpm/min, mixing time is 25~
35min。
10. according to the preparation method of claim 6~9 any one of them functionality absorbable hemostatic powder, which is characterized in that step
It is described that the step of carrying out cross-linking reaction is added in emulsion in crosslinking agent in rapid S3, it specifically includes：Crosslinking agent is configured to quality
Then cross-linking agent solution is added drop-wise in emulsion and carries out cross-linking reaction by a concentration of 1~7% cross-linking agent solution, drip speed control
At 1~2 drop/sec, cross-linking reaction time is 90~120min；Wherein, the crosslinking agent is selected from calcium chloride, glutaraldehyde, formaldehyde, capital
Buddhist nun is flat, at least one of sodium tripolyphosphate, tannic acid, counts in parts by weight, the dosage of the crosslinking agent is 3~5 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810736887.9A CN108744022A (en) | 2018-07-06 | 2018-07-06 | A kind of functionality absorbable hemostatic powder and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810736887.9A CN108744022A (en) | 2018-07-06 | 2018-07-06 | A kind of functionality absorbable hemostatic powder and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108744022A true CN108744022A (en) | 2018-11-06 |
Family
ID=63972564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810736887.9A Withdrawn CN108744022A (en) | 2018-07-06 | 2018-07-06 | A kind of functionality absorbable hemostatic powder and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108744022A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109172857A (en) * | 2018-09-10 | 2019-01-11 | 中国药科大学 | A kind of outer wound compound hemostatic material and preparation method thereof |
| CN109602942A (en) * | 2018-12-13 | 2019-04-12 | 青岛海汇生物工程有限公司 | A kind of hemostasis of chitin, pain-relieving cotton preparation method |
| CN109908396A (en) * | 2019-01-08 | 2019-06-21 | 中国人民解放军军事科学院军事医学研究院 | A kind of calcium ion-exchanged porous-starch hemostatic material and its preparation method and application |
| CN109966543A (en) * | 2019-03-22 | 2019-07-05 | 瞿应良 | A kind of preparation method of wound hemostasis packet and porous hemostat particle |
| CN110755675A (en) * | 2019-12-10 | 2020-02-07 | 中国人民解放军陆军军医大学第一附属医院 | Composite biological paste capable of rapidly stopping bleeding and preparation method and application thereof |
| CN113230447A (en) * | 2021-05-24 | 2021-08-10 | 河北工业大学 | Hemostatic repair material and preparation method thereof |
| CN115645596A (en) * | 2022-11-15 | 2023-01-31 | 广州汇芬生物科技有限公司 | Pet hemostatic powder and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101160143A (en) * | 2005-02-15 | 2008-04-09 | 弗吉尼亚大学 | Mineral technologies (mt) for acute hemostasis and for the treatment of acute wounds and chronic ulcers |
| CN103467771A (en) * | 2013-09-23 | 2013-12-25 | 潍坊美赫曼生物医药科技有限公司 | Preparation method and application of marine organism active hemostasis dressing |
| CN105031708A (en) * | 2015-08-25 | 2015-11-11 | 东莞市达庆医疗器械有限公司 | Rapid hemostatic powder for injury and preparation method of rapid hemostatic powder |
| CN105412975A (en) * | 2014-09-18 | 2016-03-23 | 苏州安德佳生物科技有限公司 | Biocompatible hemostatic product and preparation method thereof |
| CN106110378A (en) * | 2016-08-19 | 2016-11-16 | 南京大学（苏州）高新技术研究院 | A kind of spray drying method prepares method and the application of degradable chitosan styptic powder |
-
2018
- 2018-07-06 CN CN201810736887.9A patent/CN108744022A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101160143A (en) * | 2005-02-15 | 2008-04-09 | 弗吉尼亚大学 | Mineral technologies (mt) for acute hemostasis and for the treatment of acute wounds and chronic ulcers |
| CN103467771A (en) * | 2013-09-23 | 2013-12-25 | 潍坊美赫曼生物医药科技有限公司 | Preparation method and application of marine organism active hemostasis dressing |
| CN105412975A (en) * | 2014-09-18 | 2016-03-23 | 苏州安德佳生物科技有限公司 | Biocompatible hemostatic product and preparation method thereof |
| CN105031708A (en) * | 2015-08-25 | 2015-11-11 | 东莞市达庆医疗器械有限公司 | Rapid hemostatic powder for injury and preparation method of rapid hemostatic powder |
| CN106110378A (en) * | 2016-08-19 | 2016-11-16 | 南京大学（苏州）高新技术研究院 | A kind of spray drying method prepares method and the application of degradable chitosan styptic powder |
Non-Patent Citations (1)
| Title |
|---|
| 王超 等: "海藻酸钙多孔微球－白芨多糖复合止血粉的制备及止血性能评价", 《高分子通报》 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109172857A (en) * | 2018-09-10 | 2019-01-11 | 中国药科大学 | A kind of outer wound compound hemostatic material and preparation method thereof |
| CN109602942A (en) * | 2018-12-13 | 2019-04-12 | 青岛海汇生物工程有限公司 | A kind of hemostasis of chitin, pain-relieving cotton preparation method |
| CN109908396A (en) * | 2019-01-08 | 2019-06-21 | 中国人民解放军军事科学院军事医学研究院 | A kind of calcium ion-exchanged porous-starch hemostatic material and its preparation method and application |
| CN109908396B (en) * | 2019-01-08 | 2021-11-02 | 中国人民解放军军事科学院军事医学研究院 | Calcium ion exchange porous starch hemostatic material and preparation method and application thereof |
| CN109966543A (en) * | 2019-03-22 | 2019-07-05 | 瞿应良 | A kind of preparation method of wound hemostasis packet and porous hemostat particle |
| CN110755675A (en) * | 2019-12-10 | 2020-02-07 | 中国人民解放军陆军军医大学第一附属医院 | Composite biological paste capable of rapidly stopping bleeding and preparation method and application thereof |
| CN113230447A (en) * | 2021-05-24 | 2021-08-10 | 河北工业大学 | Hemostatic repair material and preparation method thereof |
| CN113230447B (en) * | 2021-05-24 | 2022-04-08 | 河北工业大学 | Hemostatic repair material and preparation method thereof |
| CN115645596A (en) * | 2022-11-15 | 2023-01-31 | 广州汇芬生物科技有限公司 | Pet hemostatic powder and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108744022A (en) | A kind of functionality absorbable hemostatic powder and preparation method thereof | |
| CN100453122C (en) | Hemostatic particles and preparation method thereof | |
| CN106620824B (en) | A kind of preparation method of high-efficiency antimicrobial compound hemostatic sponge | |
| CN107243086A (en) | A kind of absorbable compound hemostatic powder and preparation method thereof | |
| CN101596207A (en) | Be used for rapid hemostatic Pharmaceutical composition and preparation method | |
| CN113058070B (en) | Rapid hemostatic dressing and preparation method thereof | |
| CN109453424B (en) | Wound treatment dressing and preparation method thereof | |
| CN105001434A (en) | Chitosan-based multifunctional hemostasis microsphere | |
| CN108939140A (en) | Composition for hemostasis and medical hemostatic dressing | |
| CN104623719B (en) | A kind of aquagel dressing and preparation method thereof | |
| CN105194712A (en) | Hemostatic material and preparation method thereof | |
| CN108815566A (en) | A kind of preparation method of porous hemostatic starch | |
| CN101927027A (en) | Chitosan/carboxymethyl chitosan rapid hemostatic sponge and preparation method thereof | |
| CN111617310B (en) | Hemostatic sponge and preparation method and application thereof | |
| CN108096626A (en) | The preparation method of promoting healing hemostasis non-woven fabrics | |
| CN106267317A (en) | A kind of preparation method of high hemostasis medical dressing | |
| CN105107006B (en) | A kind of degradable starch-based hemostatic material and its preparation method and application | |
| CN112295008B (en) | Bioactive dressing with anti-inflammatory and hemostatic functions | |
| CN108686103A (en) | A kind of hemostatic traditional Chinese medicine composition and multifunctional emergency stop blooding composite material | |
| CN106540310A (en) | A kind of absorbability rapid hemostatic material and preparation method thereof | |
| CN110755675A (en) | Composite biological paste capable of rapidly stopping bleeding and preparation method and application thereof | |
| CN106421878A (en) | Rapidly hemostatic and antibacterial carboxylic starch-polylysine microsphere and preparation method thereof | |
| CN107308488A (en) | A kind of preparation method of the styptic powder of chloride containing calcium and sodium alginate | |
| CN106822986B (en) | A kind of preparation method of the porous ball hemostatic material of chitosan-agar oligosaccharide | |
| CN102988407A (en) | Starch-hyaluronic acid hemostatic agent and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181106 |