CN108815566A - A kind of preparation method of porous hemostatic starch - Google Patents
A kind of preparation method of porous hemostatic starch Download PDFInfo
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- CN108815566A CN108815566A CN201811099574.3A CN201811099574A CN108815566A CN 108815566 A CN108815566 A CN 108815566A CN 201811099574 A CN201811099574 A CN 201811099574A CN 108815566 A CN108815566 A CN 108815566A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The present invention relates to a kind of preparation methods of porous hemostatic starch, belong to hemostatic material in medical use technical field.The present invention is modified starch by the way that crosslinking agent and perforating agent is added, so that the polynary functional groups in alcoholic extract hydroxyl group and crosslinking agent in starch, form diether bond or diester linkage, make two and more than two starch molecule links together, the porous network microspheroidal that hyperspace is presented, improves adsorption capacity, can quickly absorb the moisture in blood, starch is small to human injury simultaneously, use process no pain；Nano-magnetic powder is mixed in porous-starch, a large amount of hole of porous-starch can provide sufficient attachment point for nano-magnetic powder；By being mixed into nano-magnetic powder, the nano-magnetic powder in magnetic powder and porous-starch hole inside porous-starch interacts, and is able to maintain the structure of porous-starch, improves the whole compactness of porous-starch, convenient for later period recycling cleaning；Porous hemostatic starch haemostatic effect prepared by the present invention is good, use process no pain.
Description
Technical field
The present invention relates to a kind of preparation methods of porous hemostatic starch, belong to hemostatic material in medical use technical field.
Background technique
With the rapid development of science and technology, hemostatic material has obtained significant progress.It is common on domestic market
Hemostatic material mainly has Fibrin Glue, gelfoam, collagen, chitosan, Chinese medicinal plant medicine and mineral drug and zeolite etc..So
And though Fibrin Glue has good adhesiveness, since it is unable to hemostasis by compression, it can not be applied individually to any big surface of a wound hemostasis,
Its blood for being originated from animal and human body of this external cause, easily causes allergy and virus infection；The porous structure of gelfoam makes to blood
There is very strong absorption, and activate blood platelet, promotes thrombosis, but it is poor to the adhesiveness of internal organ wound site, and
Degradation in vivo absorbability is poor, substantially increases the risk of wound site infection；Chitosan is natural polymer,
To human body without rejection, there is good biocompatibility and degradation property, and there is certain anthemorrhagic performance, but it is certainly
The anastalsis of body is limited, not significant for the anthemorrhagic performance of the extensive bleeding surface of a wound, often needs compound coagulation factor, chlorination
Other hemostats such as calcium.In addition, the relatively uncontrollable also biggish of its internal degradation process constrains it in surgical operation, especially
It is that the duration is long, the application in the big operation of the surface of a wound.Chinese medicinal plant medicine and mineral drug are although cheap, but proportion mode is more
Sample, the possible irritant and toxicity of part formulation, haemostatic effect is poor, needs to pressurize in many cases, inconvenient for use, is not useable for
Deep wounds lack and use dosage form in vivo；The styptic powder class of zeolite and zeolite granular, although haemostatic effect is good, speed is fast, can be used for
Wound, disaster, deep tissue caused by war wound stop blooding；And generate high temperature when stopping blooding and burn, there is certain bactericidal effect, but not
It is degradable, it is not useable for peacetime surgical operation；The heat production that absorbs water is excessively violent, may cause perienchyma's necrosis；Stop blooding it
After may remain small zeolite powder, may result in local inflammation and subsided slow and pain；As it can be seen that bleeding of skin and generality
Soft tissue bleeding have some Hemostasis, but need to further promote its safety and validity；And parenchymal viscera is created
The hemostasis in face is then still the problem that surgical field faces.
Starch is because its resource abundant and cheap cost are industrially widely used.In recent years, starch because high viscosity,
Good biocompatibility and degradable and show up prominently in technical field of biological material.Hemostasis does not contain any animal with spherex
The ingredient of source or humanized can avoid allergy risk.In addition, its good water absorption, and have the function of hydrophilic molecule strainer, lead to
Solid component in overbunching blood improves the concentration of coagulation factor near the surface of a wound and promotes to stop blooding.At the same time, starch is in body
It is interior to be degraded by amylase, it can be completely absorbed after a certain period of time, it is postoperative not cause tissue adhesion, newborn epithelium is not destroyed yet
And scab.In addition application is simple, it is extensive, also more effective new that starch base hemostatic material has become at present clinical use both at home and abroad
One of type hemostatic material stops blooding in particular for parenchymal viscera, and validity and safety are by preliminary proof.
The wound hemorrhage in burst accident, natural calamity, surgical procedure in daily life cannot be controlled effectively can be tight
Wounded's life security is threatened again.Therefore control bleeding as early as possible becomes the important measures for reducing mortality.It is existing
Hemostatic material such as stop blooding Fine band because of bleeding stopping period length, easy infection, easily adhere to wound, be not easy the disadvantages of dressing and influence it
Haemostatic effect.The hemostatic material for developing a kind of safe, fast, efficient hemostasis is of great significance for control bleeding.
Starch is a kind of from natural plants, abundance, cheap natural polymer, bio-compatible
Property it is good, be free of animal sources or humanized's ingredient, can be a kind of ideal bio-medical material by the intracorporal amylorrhexis of people.
Porous-starch is a kind of novel converted starch, there is good adsorption capacity.It can be increased by the absorption to moisture in blood
Blood viscosity will be gathered in starch particle surface in red blood cell, blood platelet, coagulation factor etc. greatly, by the solidifying of blood itself
Blood mechanism carrys out method to haemostatic effect, is a kind of ideal hemostatic material.But since the haemostatic effect of porous-starch is limited, stopped blooding
The disadvantages of structure is easily ingeniously collapsed in journey need to carry out necessary modification to it.
Summary of the invention
The technical problems to be solved by the invention：For structure in the porous hemostatic starch use process that developed now
The problem of easily loosely ingeniously collapsing, proposes a kind of preparation method of porous hemostatic starch.
In order to solve the above technical problems, the technical solution adopted by the present invention is that：
（1）Starch and deionized water is taken to be uniformly mixing to obtain gelatinized corn starch；
（2）Polysorbate60 and hexamethylene are taken, stirring is all dissolved to polysorbate60 under 55 °C of water bath conditions, obtains mixed liquor A；
（3）Gelatinized corn starch is instilled into mixed liquor A under mechanical stirring and ultrasound condition, lasting stirring and ultrasonic emulsification 20min are obtained
Starch emulsion；
（4）It takes iron ammonium sulfate, ammonium ferric sulfate, enuatrol and 60 DEG C of deionized waters to be uniformly mixed, obtains mixed liquid B, 6mol/L
Sodium hydroxide solution is miscible in 80ml starch emulsion, stirs and heating water bath is to 55 DEG C, obtain concentrated base lotion；
（5）Under rapid mixing conditions, mixed liquid B is instilled rapidly in concentrated base lotion and is reacted, then maintains 55 DEG C of water-bath
10min, then mixing speed is reduced, warming-in-water keeps the temperature 30 ~ 120min, obtains mixed liquor C to 85 DEG C；
（6）N is taken, N- methylene-bisacrylamide is simultaneously added into mixed liquor C, sequentially adds potassium peroxydisulfate and Asia after stirring 2min
Sodium bisulfate obtains mixed liquor D；
（7）Taking polyethylene glycol, sodium trimetaphosphate and deionized water are uniformly mixed and obtain mixed liquor E；
（8）Mixed liquor D and mixed liquor E are placed in microwave chemical reactor, taken out after reacting 30min under the conditions of 60 DEG C, is centrifuged
Acetone is successively used in demulsification, and for several times, filter residue and drying is obtained porous hemostasis and formed sediment by centrifugal filtration for ethyl acetate and dehydrated alcohol washing
Powder.
Step（1）The starch and the mass ratio of deionized water are 1:1.
Step（2）The mass ratio of the polysorbate60 and hexamethylene is 1:12.
Step（3）The mechanical stirring rate is 900r/min, ultrasonic power 300W.
Step（4）The mass ratio for taking iron ammonium sulfate, ammonium ferric sulfate, enuatrol and 60 DEG C of deionized waters is 10:20:
3:100。
Step（5）The quick stirring rate is 1200r/min, and filtering velocity is 600r/min after reduction.
Step（6）The mass ratio of the N, N- methylene-bisacrylamide, potassium peroxydisulfate and sodium hydrogensulfite is 1:5:1.
Step（7）The mass ratio of the polyethylene glycol, sodium trimetaphosphate and deionized water is 2:3:50.
Step（8）The mass ratio of the acetone, ethyl acetate and dehydrated alcohol is 1:1:1, washing times are 5 ~ 8 times.
The present invention is compared with other methods, and advantageous effects are：
（1）Starch is modified by the way that crosslinking agent and perforating agent is added, so that more in the alcoholic extract hydroxyl group and crosslinking agent in starch
First functional groups form diether bond or diester linkage, make two and more than two starch molecules link together, it is empty that multidimensional is presented
Between porous network microspheroidal；Since surface area increases very much, so greatly improving adsorption capacity, can quickly absorb
Moisture in blood achievees the effect that quick-acting haemostatic powder, while the safer environmental protection of starch, small to human injury, use process without
Pain；
（2）Nano-magnetic powder is mixed in porous-starch, a large amount of hole of porous-starch can provide sufficient for nano-magnetic powder
Attachment point；In porous-starch hemostasis, due to absorbing large quantity of moisture, common starch can become loose and structure is caused to be collapsed
It collapses, after being mixed into nano-magnetic powder, the nano-magnetic powder in magnetic powder and porous-starch hole inside porous-starch interacts, Neng Goubao
The structure for holding porous-starch improves the whole compactness of porous-starch, convenient for later period recycling cleaning；
（3）Porous hemostatic starch prepared by the present invention has the characteristics that mushy, can quickly absorb the moisture in blood, reach
To blood coagulation haemostatic effect, the imporosity of hemostatic starch is improved by the magnetic powder in starch, is avoided due to hemostasis
Starch absorb moisture after caused structure collapses and influence haemostatic effect.
Specific embodiment
50 ~ 100g starch and 50 ~ 100g deionized water is taken to be uniformly mixing to obtain gelatinized corn starch；Take 10 ~ 20g polysorbate60 and 120 ~
240g hexamethylene, stirring is all dissolved to polysorbate60 under 55 °C of water bath conditions, obtains mixed liquor A；In mechanical stirring and ultrasound
Under the conditions of gelatinized corn starch instilled into mixed liquor A, lasting stirring and ultrasonic emulsification 20min obtain starch emulsion；Take 20 ~ 40g sulfuric acid sub-
Iron ammonium, 40 ~ 80g ammonium ferric sulfate, 6 ~ 12g enuatrol and 200 ~ 400g60 DEG C of deionized water are uniformly mixed, and obtain mixed liquid B,
80ml6mol/L sodium hydroxide solution is miscible in 80ml starch emulsion, stirs and heating water bath is to 55 DEG C, obtain concentrated base lotion；?
Under rapid mixing conditions, mixed liquid B is instilled rapidly in concentrated base lotion and is reacted, then maintains 55 DEG C of 10min of water-bath, then reduce and stir
Speed is mixed, warming-in-water keeps the temperature 30 ~ 120min, obtain mixed liquor C to 85 DEG C；1 ~ 2gN is taken, N- methylene-bisacrylamide is simultaneously
It is added into mixed liquor C, 5 ~ 10g potassium peroxydisulfate and 1 ~ 2g sodium hydrogensulfite is sequentially added after stirring 2min, obtains mixed liquor D；
2 ~ 4g polyethylene glycol, 3 ~ 6g sodium trimetaphosphate and 50 ~ 100g deionized water are taken, is uniformly mixed and obtains mixed liquor E；By mixed liquor D
It is placed in microwave chemical reactor with mixed liquor E, is taken out after reacting 30min under the conditions of 60 DEG C, acetone is successively used in centrifugation demulsification,
Ethyl acetate and dehydrated alcohol wash 5 ~ 8 times, and filter residue and drying is obtained porous hemostatic starch by centrifugal filtration.
Example 1
50g starch and 50g deionized water is taken to be uniformly mixing to obtain gelatinized corn starch；10g polysorbate60 and 120g hexamethylene are taken, in 55 °C of water
Stirring is all dissolved to polysorbate60 under the conditions of bath, obtains mixed liquor A；Gelatinized corn starch is instilled under mechanical stirring and ultrasound condition and is mixed
Liquid A, lasting stirring and ultrasonic emulsification 20min are closed, starch emulsion is obtained；Take 20g iron ammonium sulfate, 40g ammonium ferric sulfate, 6g oleic acid
Sodium and 200g60 DEG C of deionized water are uniformly mixed, and obtain mixed liquid B, 80ml6mol/L sodium hydroxide solution is miscible in 80ml starch
Lotion, is stirred and heating water bath is to 55 DEG C, obtains concentrated base lotion；Under rapid mixing conditions, mixed liquid B is instilled into rapidly concentrated base
It is reacted in lotion, then maintains 55 DEG C of 10min of water-bath, then reduce mixing speed, warming-in-water keeps the temperature 30min, obtain to 85 DEG C
Mixed liquor C；1gN is taken, N- methylene-bisacrylamide is simultaneously added into mixed liquor C, sequentially adds 5g persulfuric acid after stirring 2min
Potassium and 1g sodium hydrogensulfite, obtain mixed liquor D；2g polyethylene glycol, 3g sodium trimetaphosphate and 50g deionized water are taken, is uniformly mixed
Obtain mixed liquor E；Mixed liquor D and mixed liquor E are placed in microwave chemical reactor, taken out after reacting 30min under the conditions of 60 DEG C,
Acetone is successively used in centrifugation demulsification, and ethyl acetate and dehydrated alcohol wash 5 times, centrifugal filtration, by filter residue and drying, obtains porous stop
Blood starch.
Example 2
75g starch and 75g deionized water is taken to be uniformly mixing to obtain gelatinized corn starch；15g polysorbate60 and 180g hexamethylene are taken, in 55 °C of water
Stirring is all dissolved to polysorbate60 under the conditions of bath, obtains mixed liquor A；Gelatinized corn starch is instilled under mechanical stirring and ultrasound condition and is mixed
Liquid A, lasting stirring and ultrasonic emulsification 20min are closed, starch emulsion is obtained；Take 30g iron ammonium sulfate, 60g ammonium ferric sulfate, 9g oleic acid
Sodium and 300g60 DEG C of deionized water are uniformly mixed, and obtain mixed liquid B, 80ml6mol/L sodium hydroxide solution is miscible in 80ml starch
Lotion, is stirred and heating water bath is to 55 DEG C, obtains concentrated base lotion；Under rapid mixing conditions, mixed liquid B is instilled into rapidly concentrated base
It is reacted in lotion, then maintains 55 DEG C of 10min of water-bath, then reduce mixing speed, warming-in-water keeps the temperature 75min, obtain to 85 DEG C
Mixed liquor C；1 ~ 2gN is taken, N- methylene-bisacrylamide is simultaneously added into mixed liquor C, sequentially adds 7g over cure after stirring 2min
Sour potassium and 1.5g sodium hydrogensulfite, obtain mixed liquor D；3g polyethylene glycol, 4.5g sodium trimetaphosphate and 75g deionized water are taken, is mixed
It closes and uniformly obtains mixed liquor E；Mixed liquor D and mixed liquor E are placed in microwave chemical reactor, react 30min under the conditions of 60 DEG C
After take out, acetone is successively used in centrifugation demulsification, and ethyl acetate and dehydrated alcohol wash 7 times, and centrifugal filtration obtains filter residue and drying
Porous hemostatic starch.
Example 3
100g starch and 100g deionized water is taken to be uniformly mixing to obtain gelatinized corn starch；20g polysorbate60 and 240g hexamethylene are taken, at 55 °C
Stirring is all dissolved to polysorbate60 under water bath condition, obtains mixed liquor A；Gelatinized corn starch is instilled under mechanical stirring and ultrasound condition
Mixed liquor A, lasting stirring and ultrasonic emulsification 20min, obtain starch emulsion；Take 40g iron ammonium sulfate, 80g ammonium ferric sulfate, 12g
Enuatrol and 400g60 DEG C of deionized water are uniformly mixed, and obtain mixed liquid B, 80ml6mol/L sodium hydroxide solution is miscible in 80ml
Starch emulsion, is stirred and heating water bath is to 55 DEG C, obtains concentrated base lotion；Under rapid mixing conditions, mixed liquid B is instilled rapidly
It is reacted in concentrated base lotion, then maintains 55 DEG C of 10min of water-bath, then reduce mixing speed, warming-in-water is to 85 DEG C, heat preservation
120min obtains mixed liquor C；2gN is taken, N- methylene-bisacrylamide is simultaneously added into mixed liquor C, successively adds after stirring 2min
Enter 10g potassium peroxydisulfate and 2g sodium hydrogensulfite, obtains mixed liquor D；Take 4g polyethylene glycol, 6g sodium trimetaphosphate and 100g deionization
Water is uniformly mixed and obtains mixed liquor E；Mixed liquor D and mixed liquor E are placed in microwave chemical reactor, reacted under the conditions of 60 DEG C
It is taken out after 30min, centrifugation demulsification, successively uses acetone, ethyl acetate and dehydrated alcohol wash 8 times, and filter residue is done in centrifugal filtration
It is dry, obtain porous hemostatic starch.
Porous hemostatic starch prepared by the present invention and commercially available hemostatic starch is taken to be detected, specific testing result is as follows：
（1）Detection method：
Liver placenta percreta area 2cm × 1cm, Wound depth 0.3cm are cut with scalpel in pig liver surface, bleeding wound is made
The experiment hemostatic material in face, use has：The porous hemostatic starch of example 1-3 stops blooding to the surface of a wound, and with commercially available hemostatic starch
For control group.After bleeding, porous hemostatic starch will be stopped immediately on wound and with medical surgical gloves or hemostatic gauze porous
It presses on hemostatic starch, blocking blood flow gently unclamps gloves or gauze after 1~2min, observation haemostatic effect, gloves and gauze
Whether adhesion and sludged blood, bleeding again is caused when opening.Without taking away porous hemostatic starch after hemostasis, but use physiology salt
Water does appropriate infiltration and rinses.
Test result：
The porous hemostatic starch experimental group haemostatic effect of example 1-3 is ideal and easy to use.The porous hemostasis of experimental group is formed sediment
Powder meets after blood water suction/blood immediately and forms the porous hemostatic starch sludged blood colloid of viscosity with blood, equal in 1-2 minute
The bleeding of the liver surface of a wound can be efficiently controlled, the bright commercially available hemostatic starch of control group needs 5-10 minutes or above time just can be with
Control bleeding.With liver wound tissue tight adhesion after the porous hemostatic starch chance blood of experimental group, promote blood coagulation, and formed to wound
The sealing process of face blutpunkte damaged blood vessels.The porous blood starch of experimental group is easy to operate, easy to use, gloves or yarn with pressing
Cloth dressing does not stick together, and sludged blood will not be destroyed when opening gloves or gauze, not will cause bleeding again.And control group is commercially available
Hemostatic starch water suction/blood speed is slow, must repeatedly squeeze cavernous body, and very weak with the tissue adherence of the surface of a wound, haemostatic effect is poor.
Claims (9)
1. a kind of preparation method of porous hemostatic starch, which is characterized in that specific production step is：
（1）Starch and deionized water is taken to be uniformly mixing to obtain gelatinized corn starch；
（2）Polysorbate60 and hexamethylene are taken, stirring is all dissolved to polysorbate60 under 55 °C of water bath conditions, obtains mixed liquor A；
（3）Gelatinized corn starch is instilled into mixed liquor A under mechanical stirring and ultrasound condition, lasting stirring and ultrasonic emulsification 20min are obtained
Starch emulsion；
（4）It takes iron ammonium sulfate, ammonium ferric sulfate, enuatrol and 60 DEG C of deionized waters to be uniformly mixed, obtains mixed liquid B, 6mol/L
Sodium hydroxide solution is miscible in 80ml starch emulsion, stirs and heating water bath is to 55 DEG C, obtain concentrated base lotion；
（5）Under rapid mixing conditions, mixed liquid B is instilled rapidly in concentrated base lotion and is reacted, then maintains 55 DEG C of water-bath
10min, then mixing speed is reduced, warming-in-water keeps the temperature 30 ~ 120min, obtains mixed liquor C to 85 DEG C；
（6）N is taken, N- methylene-bisacrylamide is simultaneously added into mixed liquor C, sequentially adds potassium peroxydisulfate and Asia after stirring 2min
Sodium bisulfate obtains mixed liquor D；
（7）Taking polyethylene glycol, sodium trimetaphosphate and deionized water are uniformly mixed and obtain mixed liquor E；
（8）Mixed liquor D and mixed liquor E are placed in microwave chemical reactor, taken out after reacting 30min under the conditions of 60 DEG C, is centrifuged
Acetone is successively used in demulsification, and for several times, filter residue and drying is obtained porous hemostasis and formed sediment by centrifugal filtration for ethyl acetate and dehydrated alcohol washing
Powder.
2. a kind of preparation method of porous hemostatic starch as described in claim 1, which is characterized in that step（1）The starch
Mass ratio with deionized water is 1:1.
3. a kind of preparation method of porous hemostatic starch as described in claim 1, which is characterized in that step（2）The tween
60 and hexamethylene mass ratio be 1:12.
4. a kind of preparation method of porous hemostatic starch as described in claim 1, which is characterized in that step（3）The machinery
Stirring rate is 900r/min, ultrasonic power 300W.
5. a kind of preparation method of porous hemostatic starch as described in claim 1, which is characterized in that step（4）It is described to take sulphur
Sour ferrous ammonium, ammonium ferric sulfate, enuatrol and 60 DEG C of deionized waters mass ratio be 10:20:3:100.
6. a kind of preparation method of porous hemostatic starch as described in claim 1, which is characterized in that step（5）It is described quick
Stirring rate is 1200r/min, and filtering velocity is 600r/min after reduction.
7. a kind of preparation method of porous hemostatic starch as described in claim 1, which is characterized in that step（6）The N, N-
The mass ratio of methylene-bisacrylamide, potassium peroxydisulfate and sodium hydrogensulfite is 1:5:1.
8. a kind of preparation method of porous hemostatic starch as described in claim 1, which is characterized in that step（7）The poly- second
The mass ratio of glycol, sodium trimetaphosphate and deionized water is 2:3:50.
9. a kind of preparation method of porous hemostatic starch as described in claim 1, which is characterized in that step（8）The acetone,
The mass ratio of ethyl acetate and dehydrated alcohol is 1:1:1, washing times are 5 ~ 8 times.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110665049A (en) * | 2019-10-25 | 2020-01-10 | 石家庄亿生堂医用品有限公司 | Method for preparing hemostatic starch microspheres by ultrasonic |
| CN112121225A (en) * | 2020-10-16 | 2020-12-25 | 广西大学 | Nanocomposite hydrogel for bleeding control and preparation method thereof |
| CN112315660A (en) * | 2020-12-23 | 2021-02-05 | 广州牧蓝春生物科技有限公司 | Biodegradable nanofiber medical bandage and preparation method thereof |
| CN112891612A (en) * | 2021-01-28 | 2021-06-04 | 西南大学 | Preparation method of janus structure hemostatic with directional driving function |
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| CN112315660A (en) * | 2020-12-23 | 2021-02-05 | 广州牧蓝春生物科技有限公司 | Biodegradable nanofiber medical bandage and preparation method thereof |
| CN112891612A (en) * | 2021-01-28 | 2021-06-04 | 西南大学 | Preparation method of janus structure hemostatic with directional driving function |
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Application publication date: 20181116 |